TDMS Study 88034-07 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
OZONE/NNK
NTP Experiment-Test: 88034-07 Report: PEIRPT03
Study Type: CHRONIC Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:01:31
Facility: Battelle Northwest
Chemical CAS #: 10028-15-6
Lock Date: 02/17/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88034-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OZONE/NNK Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:01:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE TRIOCT./ .1MG/KG TRIOCT./ .1M/KNNK 1M/K NNK 1 MG/KG
AIR NNK/AIR OZONE /OZONE /OZONE NNK/AIR
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DISPOSITION SUMMARY
Animals Initially In Study 48 48 48 48 48 48
Early Deaths
Moribund Sacrifice 36 40 36 38 36 41
Natural Death 4 2 9 4 7 3
Survivors
Terminal Sacrifice 8 6 3 6 5 4
Animals Examined Microscopically 48 48 48 48 48 48
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ALIMENTARY SYSTEM
Intestine Large, Colon (1) (1) (1)
Mineralization 1 (100%) 1 (100%)
Lymphoid Tissue, Hyperplasia, Lymphoid 1 (100%)
Intestine Large, Rectum (1) (1)
Mineralization 1 (100%)
Intestine Large, Cecum (1) (1) (2) (1)
Ulcer 1 (50%) 1 (100%)
Intestine Small, Ileum (1) (1) (1) (1)
Hyperplasia, Lymphoid 1 (100%)
Peyer's Patch, Hyperplasia, Lymphoid 1 (100%)
Liver (26) (27) (28) (36) (42) (39)
Angiectasis 1 (4%) 3 (11%) 3 (8%) 5 (12%)
Degeneration, Cystic 5 (19%) 3 (11%) 4 (14%) 8 (22%) 17 (40%) 7 (18%)
Hepatodiaphragmatic Nodule 4 (15%) 2 (7%) 1 (4%) 3 (8%) 5 (12%) 1 (3%)
Hyperplasia 2 (5%)
Hyperplasia, Focal 1 (4%) 1 (4%) 1 (4%) 7 (17%) 4 (10%)
Infiltration Cellular, Mixed Cell 1 (4%) 1 (2%)
Inflammation 1 (3%)
Necrosis 1 (4%)
Necrosis, Focal 1 (4%) 3 (7%) 3 (8%)
Vacuolization Cytoplasmic 1 (4%) 4 (15%) 4 (14%) 4 (11%) 2 (5%) 2 (5%)
Vacuolization Cytoplasmic, Focal 1 (4%) 1 (4%) 1 (2%)
Bile Duct, Hyperplasia 1 (4%) 2 (7%) 1 (4%) 1 (2%)
Centrilobular, Necrosis 1 (4%) 1 (2%)
Mesentery (8) (10) (8) (11) (8) (8)
Fat, Necrosis 7 (88%) 9 (90%) 5 (63%) 7 (64%) 8 (100%) 6 (75%)
Oral Mucosa (4) (1)
Pharyngeal, Foreign Body 1 (100%)
Pharyngeal, Hyperplasia, Squamous 2 (50%)
Pancreas (1) (1) (1)
Artery, Inflammation, Chronic 1 (100%)
Stomach, Forestomach (1) (2) (1) (2) (1)
Hyperplasia, Squamous 2 (100%)
Inflammation, Chronic Active 1 (100%) 1 (50%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 88034-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OZONE/NNK Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:01:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE TRIOCT./ .1MG/KG TRIOCT./ .1M/KNNK 1M/K NNK 1 MG/KG
AIR NNK/AIR OZONE /OZONE /OZONE NNK/AIR
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Mineralization 1 (100%) 1 (50%)
Ulcer 1 (50%)
Stomach, Glandular (1) (1) (3) (1) (3)
Inflammation, Chronic Active 1 (100%)
Mineralization 1 (100%) 2 (67%)
Necrosis 1 (33%) 1 (33%)
Tooth (1) (1)
Developmental Malformation 1 (100%) 1 (100%)
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CARDIOVASCULAR SYSTEM
Blood Vessel (2) (1)
Inflammation, Chronic 1 (100%)
Mineralization 1 (100%)
Aorta, Mineralization 2 (100%)
Heart (1) (1) (1) (2) (2)
Cardiomyopathy 1 (100%)
Fibrosis 1 (50%)
Mineralization 1 (100%)
Necrosis 1 (100%)
Atrium, Thrombosis 1 (50%)
Pericardium, Fibrosis 1 (50%)
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ENDOCRINE SYSTEM
Adrenal Cortex (4) (1) (3) (1) (4)
Angiectasis 1 (33%)
Vacuolization Cytoplasmic 1 (25%)
Adrenal Medulla (4) (1) (1)
Hemorrhage 1 (25%)
Parathyroid Gland (2) (1) (1) (1)
Hyperplasia 2 (100%) 1 (100%) 1 (100%) 1 (100%)
Pituitary Gland (34) (35) (29) (27) (30) (34)
Pars Distalis, Hemorrhage 1 (3%)
Pars Distalis, Hyperplasia 1 (3%) 1 (3%) 2 (7%) 2 (6%)
Thyroid Gland (3) (2) (1) (1) (1)
Follicular Cell, Hyperplasia 1 (100%)
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GENERAL BODY SYSTEM
Peritoneum (32) (24) (30) (31) (26) (32)
Inflammation, Chronic 30 (94%) 24 (100%) 30 (100%) 30 (97%) 26 (100%) 32 (100%)
Tissue NOS (1) (5) (1)
Mediastinum, Inflammation, Chronic Active,
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 88034-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OZONE/NNK Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:01:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE TRIOCT./ .1MG/KG TRIOCT./ .1M/KNNK 1M/K NNK 1 MG/KG
AIR NNK/AIR OZONE /OZONE /OZONE NNK/AIR
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - CONT
Diffuse 1 (20%)
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GENITAL SYSTEM
Epididymis (1) (1)
Granuloma Sperm 1 (100%)
Penis (4) (3) (1) (2) (5)
Calculus Gross Observation 1 (33%)
Calculus Micro Observation Only 1 (33%) 1 (100%)
Edema 2 (100%)
Inflammation, Chronic Active 2 (50%) 2 (40%)
Preputial Gland (8) (6) (8) (2) (3) (9)
Inflammation, Chronic Active 6 (75%) 2 (33%) 5 (63%) 1 (50%) 3 (100%) 7 (78%)
Inflammation, Suppurative 1 (13%)
Prostate (2) (1) (2)
Inflammation, Suppurative 2 (100%) 1 (100%) 2 (100%)
Testes (20) (9) (24) (25) (19) (13)
Atrophy 6 (30%) 1 (11%) 1 (4%) 5 (20%) 1 (5%) 3 (23%)
Necrosis 1 (4%)
Interstitial Cell, Hyperplasia 2 (10%)
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HEMATOPOIETIC SYSTEM
Lymph Node (9) (7) (10) (10) (17) (26)
Hyperplasia, Lymphoid 1 (10%)
Infiltration Cellular, Plasma Cell 1 (11%)
Pigmentation 1 (10%)
Iliac, Infiltration Cellular, Plasma Cell 1 (11%) 1 (6%)
Iliac, Pigmentation 1 (6%)
Pancreatic, Hyperplasia, Lymphoid 1 (10%)
Pancreatic, Inflammation, Granulomatous 1 (11%) 1 (4%)
Renal, Hemorrhage 1 (11%) 1 (10%) 1 (10%) 3 (12%)
Renal, Hyperplasia, Lymphoid 1 (10%)
Renal, Infiltration Cellular, Plasma Cell 4 (44%) 1 (14%) 1 (10%) 1 (6%) 5 (19%)
Renal, Inflammation, Granulomatous 1 (11%) 2 (29%) 1 (10%) 1 (6%) 1 (4%)
Lymph Node, Bronchial (38) (32) (23) (26) (30) (28)
Hemorrhage 1 (3%) 1 (3%) 1 (4%) 2 (8%)
Hyperplasia, Lymphoid 2 (5%) 1 (4%)
Necrosis 1 (3%)
Lymph Node, Mandibular (4) (8) (7) (7) (15) (14)
Hyperplasia, Lymphoid 1 (7%)
Infiltration Cellular, Plasma Cell 5 (71%) 1 (14%) 1 (7%) 3 (21%)
Necrosis 1 (7%)
Lymph Node, Mesenteric (2) (8) (3) (11) (8) (9)
Hyperplasia, Lymphoid 1 (33%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 88034-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OZONE/NNK Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:01:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE TRIOCT./ .1MG/KG TRIOCT./ .1M/KNNK 1M/K NNK 1 MG/KG
AIR NNK/AIR OZONE /OZONE /OZONE NNK/AIR
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Inflammation, Granulomatous 1 (13%) 1 (9%)
Lymph Node, Mediastinal (42) (37) (43) (43) (43) (45)
Fibrosis 1 (2%)
Hemorrhage 2 (5%) 1 (3%) 3 (7%) 2 (5%) 2 (4%)
Infiltration Cellular, Plasma Cell 2 (5%) 1 (3%) 2 (5%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Necrosis 1 (3%) 1 (2%)
Spleen (35) (32) (33) (37) (39) (39)
Accessory Spleen 1 (3%) 1 (3%) 1 (3%) 4 (10%)
Atrophy 1 (3%)
Congestion 2 (6%) 2 (6%) 1 (3%)
Fibrosis 12 (34%) 14 (44%) 7 (21%) 12 (32%) 13 (33%) 10 (26%)
Hematopoietic Cell Proliferation 1 (3%) 1 (3%) 1 (3%) 1 (3%) 1 (3%)
Hemorrhage 2 (6%)
Necrosis 1 (3%) 1 (3%) 1 (3%) 3 (8%)
Capsule, Fibrosis 1 (3%)
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INTEGUMENTARY SYSTEM
Mammary Gland (4) (5) (2) (4) (5)
Galactocele 2 (50%) 3 (60%) 2 (100%) 2 (50%) 4 (80%)
Hyperplasia 1 (25%) 2 (40%) 1 (25%) 1 (20%)
Inflammation, Chronic 1 (20%) 1 (20%)
Skin (47) (47) (48) (48) (48) (47)
Hyperkeratosis 2 (4%) 1 (2%) 2 (4%) 3 (6%)
Hyperplasia 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%) 1 (2%) 2 (4%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Ulcer 2 (4%) 1 (2%)
Dermis, Cyst 1 (2%) 1 (2%)
Prepuce, Inflammation, Suppurative 1 (2%) 3 (6%) 3 (6%) 2 (4%) 1 (2%)
Sebaceous Gland, Hyperplasia 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic 1 (2%) 1 (2%)
Subcutaneous Tissue, Necrosis 1 (2%)
Subcutaneous Tissue, Skin, Site of
Application, Inflammation, Chronic 46 (98%) 47 (100%) 48 (100%) 47 (98%) 48 (100%) 47 (100%)
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MUSCULOSKELETAL SYSTEM
None
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a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 88034-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OZONE/NNK Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:01:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE TRIOCT./ .1MG/KG TRIOCT./ .1M/KNNK 1M/K NNK 1 MG/KG
AIR NNK/AIR OZONE /OZONE /OZONE NNK/AIR
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (2) (1)
Hemorrhage 1 (100%)
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RESPIRATORY SYSTEM
Larynx (48) (48) (48) (48) (48) (48)
Foreign Body 3 (6%) 2 (4%) 2 (4%)
Inflammation, Suppurative 1 (2%) 4 (8%) 3 (6%) 3 (6%) 6 (13%)
Metaplasia, Squamous 1 (2%)
Mineralization 1 (2%) 1 (2%)
Lung (48) (48) (48) (48) (48) (48)
Congestion 2 (4%) 2 (4%) 5 (10%) 3 (6%)
Edema 1 (2%) 3 (6%) 1 (2%)
Fibrosis, Focal 2 (4%) 1 (2%) 1 (2%)
Hemorrhage 3 (6%) 2 (4%) 2 (4%) 1 (2%) 3 (6%) 5 (10%)
Mineralization 4 (8%) 2 (4%)
Alveolar Epithelium, Hyperplasia 1 (2%)
Alveolar Epithelium, Hyperplasia, Atypical 10 (21%) 12 (25%) 33 (69%) 39 (81%)
Alveolar Epithelium, Metaplasia 35 (73%) 47 (98%) 45 (94%)
Alveolus, Infiltration Cellular, Focal,
Histiocyte 1 (2%) 1 (2%)
Alveolus, Infiltration Cellular, Histiocyte 1 (2%) 1 (2%) 7 (15%) 9 (19%) 13 (27%) 8 (17%)
Bronchus, Inflammation, Suppurative 1 (2%)
Interstitium, Fibrosis 34 (71%) 46 (96%) 45 (94%)
Interstitium, Inflammation, Chronic, Diffuse 3 (6%) 1 (2%) 2 (4%)
Perivascular, Inflammation, Chronic 1 (2%)
Serosa, Fibrosis 1 (2%)
Serosa, Inflammation, Chronic Active 1 (2%)
Nose (47) (48) (48) (48) (46) (48)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%) 3 (6%) 3 (6%) 1 (2%) 5 (10%)
Thrombosis 1 (2%)
Goblet Cell, Lateral Wall, Hyperplasia 3 (6%) 38 (79%) 45 (94%) 42 (91%) 3 (6%)
Lateral Wall, Hyperplasia 5 (11%) 4 (8%) 46 (96%) 48 (100%) 46 (100%) 5 (10%)
Nasopharyngeal Duct, Infiltration Cellular,
Mixed Cell 1 (2%)
Olfactory Epithelium, Degeneration, Hyaline 47 (100%) 48 (100%) 47 (98%) 48 (100%) 46 (100%) 45 (94%)
Olfactory Epithelium, Metaplasia 1 (2%) 4 (8%) 1 (2%) 1 (2%) 2 (4%)
Turbinate, Necrosis 1 (2%) 1 (2%)
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a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 88034-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OZONE/NNK Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:01:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE TRIOCT./ .1MG/KG TRIOCT./ .1M/KNNK 1M/K NNK 1 MG/KG
AIR NNK/AIR OZONE /OZONE /OZONE NNK/AIR
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (3) (1) (4) (1)
Cataract 3 (100%) 1 (100%) 2 (50%) 1 (100%)
Hemorrhage 1 (33%) 1 (25%)
Ciliary Body, Retina, Degeneration 2 (67%) 1 (100%) 2 (50%)
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URINARY SYSTEM
Kidney (27) (22) (15) (20) (25) (24)
Cyst 1 (4%) 2 (13%) 1 (4%)
Hydronephrosis 1 (4%)
Infarct 1 (5%) 1 (4%) 2 (8%)
Nephropathy 27 (100%) 22 (100%) 14 (93%) 18 (90%) 22 (88%) 22 (92%)
Pigmentation, Hemosiderin 1 (5%)
Urinary Bladder (2) (2) (3) (1) (1)
Calculus Gross Observation 1 (50%)
Calculus Micro Observation Only 1 (50%) 1 (100%)
Hemorrhage 1 (50%) 2 (67%) 1 (100%)
Inflammation, Chronic Active 1 (50%)
Inflammation, Suppurative 1 (100%)
Transitional Epithelium, Necrosis 1 (33%)
a Number of animals examined microscopically at site and number of animals with lesion
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