Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/3684

TDMS Study 88034-07 Pathology Tables

NTP Experiment-Test: 88034-07                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:25:56




       Facility:  Battelle Northwest

       Chemical CAS #:  10028-15-6

       Lock Date:  02/17/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1


NTP Experiment-Test: 88034-07                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:25:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 6| 5| 5| 6| 5| 6| 7| 6| 7| 5| 6| 6| 7| 6| 5| 6| 7| 6| 5| 4| 5|             
                             DAY ON TEST   | 4| 0| 0| 3| 3| 4| 8| 1| 6| 9| 3| 3| 3| 6| 0| 2| 3| 6| 5| 9| 0| 5| 5| 8| 6|             
                                           | 3| 0| 0| 6| 8| 0| 9| 1| 2| 8| 6| 3| 6| 4| 4| 0| 6| 9| 6| 7| 4| 5| 6| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    TRIOCT./                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    AIR                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                        +                                 |             
      Polyp Adenomatous                    |                                        X                                 |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +     +     +        +  +     +           +  +     +  +  +     +  +|             
      Cholangiocarcinoma                   |       X                                                                  |             
      Leukemia Mononuclear                 |             X     X        X  X     X                       X  X     X  X|             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                 +  +     +                                 |             
      Leukemia Mononuclear                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                |                                                       +                  |             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +                                                                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +                                                                     |             
                                            __________________________________________________________________________|             
   Tongue                                  |                            +                                             |             
      Squamous Cell Papilloma              |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +                                                                     |             
                                            __________________________________________________________________________|             
   Heart                                   |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |                +                                                  +      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |                +                                               +         |             
      Pheochromocytoma Malignant           |                X                                                         |             
      Pheochromocytoma Benign              |                                                                X         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                                                                      +   |             
      Carcinoma                            |                                                                      X   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +                                                                     |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +           +  +  +        +  +  +  +  +  +  +  +     +  +     +  +|             
      Leukemia Mononuclear                 | X                                                                        |             
      Pars Distalis, Adenoma               | X  X  X           X  X  X        X  X  X     X  X  X  X     X  X     X  X|             
      Pars Distalis, Carcinoma             |                                           X                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                                                    +     +               |             
      Carcinoma                            |                                                          X               |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Adenoma             |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |    +  +  +  +     +  +     +  +  +           +  +  +  +  +     +     +  +|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Sarcoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                                                             +            |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   2                                                               
NTP Experiment-Test: 88034-07                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:25:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 6| 5| 5| 6| 5| 6| 7| 6| 7| 5| 6| 6| 7| 6| 5| 6| 7| 6| 5| 4| 5|             
                             DAY ON TEST   | 4| 0| 0| 3| 3| 4| 8| 1| 6| 9| 3| 3| 3| 6| 0| 2| 3| 6| 5| 9| 0| 5| 5| 8| 6|             
                                           | 3| 0| 0| 6| 8| 0| 9| 1| 2| 8| 6| 3| 6| 4| 4| 0| 6| 9| 6| 7| 4| 5| 6| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    TRIOCT./                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    AIR                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +                                +                             +         |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +           +  +           +        +           +  +     +  +            |             
      Mesothelioma Malignant               |                                                                          |             
      Interstitial Cell, Adenoma           |             X              X        X           X  X     X  X            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +           +           +  +                                       |             
      Iliac, Leukemia Mononuclear          |                                  X                                       |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
      Renal, Leukemia Mononuclear          |                                  X                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  M  M  +  M  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M|             
      Leukemia Mononuclear                 | X           X                 X  X     X              X     X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +           +              +                                             |             
      Leukemia Mononuclear                 | X           X              X                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                        +              +                  |             
      Leukemia Mononuclear                 |                                        X              X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M|             
      Leukemia Mononuclear                 | X           X     X        X  X  X     X              X     X            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +     +        +  +     +  +     +  +     +     +  +  +  +  +|             
      Fibroma                              |                                                                          |             
      Leukemia Mononuclear                 | X        X  X     X        X  X     X  X     X        X     X  X  X  X  X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                                  +              +                        |             
      Fibroadenoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                               X                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                            X  X                                          |             
      Subcutaneous Tissue, Skin, Site of   |                                                                          |             
          Application, Sarcoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   3                                                               
NTP Experiment-Test: 88034-07                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:25:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 6| 5| 5| 6| 5| 6| 7| 6| 7| 5| 6| 6| 7| 6| 5| 6| 7| 6| 5| 4| 5|             
                             DAY ON TEST   | 4| 0| 0| 3| 3| 4| 8| 1| 6| 9| 3| 3| 3| 6| 0| 2| 3| 6| 5| 9| 0| 5| 5| 8| 6|             
                                           | 3| 0| 0| 6| 8| 0| 9| 1| 2| 8| 6| 3| 6| 4| 4| 0| 6| 9| 6| 7| 4| 5| 6| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    TRIOCT./                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    AIR                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Cholangiocarcinoma, Metastatic, Liver|       X                                                                  |             
      Leukemia Mononuclear                 | X           X     X        X  X        X              X     X        X  X|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                X         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +     +              +  +     +        +  +  +        +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Sarcoma, Metastatic, Tissue NOS      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X        X  X     X        X  X  X  X  X     X        X     X  X  X  X  X|             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   4                                                               
NTP Experiment-Test: 88034-07                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:25:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 5| 6| 3| 7| 7| 6| 5| 6| 6| 6|     |            |
                             DAY ON TEST   | 6| 6| 7| 0| 3| 8| 6| 3| 0| 1| 8| 4| 3| 1| 1| 2| 2| 3| 9| 7| 2| 7| 1|     |            |
                                           | 4| 6| 2| 6| 6| 1| 3| 6| 9| 7| 5| 1| 6| 5| 1| 7| 4| 6| 2| 6| 0| 3| 3|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   FISCHER 344 RATS MALE                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     A      |
    TRIOCT./                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |     L      |
    AIR                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|     |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |   1        |
      Polyp Adenomatous                    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   |       +     +  +     +  +  +  +           +  +  +              +  +      |  26        |
      Cholangiocarcinoma                   |                                                                          |          1 |
      Leukemia Mononuclear                 |       X     X  X           X  X           X  X                    X      |         17 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +  +        +                                   +            |   8        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |   1        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Squamous Cell Papilloma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                 +                        |   2        |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |    +                                                           +         |   4        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |          +                                +                              |   4        |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |          X                                X                              |          3 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                         +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +        +  +        +  +  +  +  +  M  +  +        +  +  +  +  +  +      |  34        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Pars Distalis, Adenoma               | X        X           X  X  X  X  X     X  X        X  X  X  X  X  X      |         32 |
      Pars Distalis, Carcinoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                 +                        |   3        |
      Carcinoma                            |                                                                          |          1 |
      C-Cell, Carcinoma                    |                                                 X                        |          1 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peritoneum                              | +  +  +  +     +        +        +     +  +  +  +  +     +     +  +      |  32        |
      Mesothelioma Malignant               |    X  X                                                                  |          2 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   5                                                               
NTP Experiment-Test: 88034-07                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:25:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 5| 6| 3| 7| 7| 6| 5| 6| 6| 6|     |            |
                             DAY ON TEST   | 6| 6| 7| 0| 3| 8| 6| 3| 0| 1| 8| 4| 3| 1| 1| 2| 2| 3| 9| 7| 2| 7| 1|     |            |
                                           | 4| 6| 2| 6| 6| 1| 3| 6| 9| 7| 5| 1| 6| 5| 1| 7| 4| 6| 2| 6| 0| 3| 3|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   FISCHER 344 RATS MALE                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     A      |
    TRIOCT./                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |     L      |
    AIR                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|     |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                   +                                                      |   1        |
      Sarcoma                              |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |             +     +           +              +           +               |   8        |
      Adenoma                              |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  |    +  +  +  +  +  +  +              +           +              +  +      |  20        |
      Mesothelioma Malignant               |    X  X                                                                  |          2 |
      Interstitial Cell, Adenoma           |       X  X  X  X     X              X           X              X         |         15 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |             +                 +           +           +        +         |   9        |
      Iliac, Leukemia Mononuclear          |                                           X                              |          2 |
      Pancreatic, Leukemia Mononuclear     |                               X                                          |          1 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  M  +  M  +  +  +      |  38        |
      Leukemia Mononuclear                 | X     X                    X  X     X        X                    X      |         14 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                               +                                          |   4        |
      Leukemia Mononuclear                 |                               X                                          |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                          |   2        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  I  +  +  +  I  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +      |  42        |
      Leukemia Mononuclear                 | X     X                    X  X           X                       X      |         15 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +  +  +  +     +  +  +  +     +  +  +  +     +  +        +  +      |  35        |
      Fibroma                              |                            X                                             |          1 |
      Leukemia Mononuclear                 | X     X     X  X           X  X     X  X  X  X     X              X      |         27 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                     +                 +                  |   4        |
      Fibroadenoma                         |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +      |  47        |
      Keratoacanthoma                      |                            X                                             |          2 |
      Squamous Cell Carcinoma              |                X                                                         |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          2 |
      Subcutaneous Tissue, Skin, Site of   |                                                                          |            |
          Application, Sarcoma             | X              X                                      X                  |          3 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   6                                                               
NTP Experiment-Test: 88034-07                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:25:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 5| 6| 3| 7| 7| 6| 5| 6| 6| 6|     |            |
                             DAY ON TEST   | 6| 6| 7| 0| 3| 8| 6| 3| 0| 1| 8| 4| 3| 1| 1| 2| 2| 3| 9| 7| 2| 7| 1|     |            |
                                           | 4| 6| 2| 6| 6| 1| 3| 6| 9| 7| 5| 1| 6| 5| 1| 7| 4| 6| 2| 6| 0| 3| 3|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   FISCHER 344 RATS MALE                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     A      |
    TRIOCT./                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |     L      |
    AIR                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|     |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Alveolar/Bronchiolar Adenoma         |             X        X                             X                     |          3 |
      Alveolar/Bronchiolar Carcinoma       |                                                    X                     |          1 |
      Cholangiocarcinoma, Metastatic, Liver|                                                                          |          1 |
      Leukemia Mononuclear                 | X     X                    X  X           X  X                    X      |         17 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +      |  47        |
      Leukemia Mononuclear                 |                                                                   X      |          2 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                          +                                             |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |          +  +  +  +  +  +  +     +  +           +  +  +        +  +      |  27        |
      Leukemia Mononuclear                 |                                                                   X      |          1 |
      Sarcoma, Metastatic, Tissue NOS      |                   X                                                      |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Leukemia Mononuclear                 | X     X     X  X           X  X     X  X  X  X     X              X      |         28 |
      Mesothelioma Malignant               |    X  X                                                                  |          2 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   7                                                               
NTP Experiment-Test: 88034-07                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:25:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 6| 7| 5| 4| 5| 7| 6| 6| 4| 7| 6| 6| 7| 5| 5| 5| 6| 6| 6| 6| 5| 5| 6|             
                             DAY ON TEST   | 1| 7| 1| 3| 8| 6| 4| 1| 8| 2| 6| 3| 6| 4| 0| 8| 0| 1| 3| 5| 2| 3| 8| 5| 8|             
                                           | 7| 8| 2| 6| 2| 6| 4| 0| 3| 0| 0| 6| 2| 1| 4| 9| 1| 8| 3| 5| 5| 5| 9| 7| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .1MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    NNK/AIR                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                                    +                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                                                                          |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |       +     +     +     +  +     +     +     +  +     +  +     +  +     +|             
      Leukemia Mononuclear                 |       X     X     X     X  X           X     X  X     X  X        X      |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                 +  +     +  +                 +                  |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |          +                                                     +         |             
      Pharyngeal, Squamous Cell Papilloma  |                                                                X         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                      +                                               +   |             
      Adenoma                              |                      X                                               X   |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +     +  +     +  +  +  +     +        +  +     +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
      Pars Distalis, Adenoma               |    X     X  X     X  X  X  X     X           X     X  X  X  X  X  X  X  X|             
      Pars Distalis, Leukemia Mononuclear  |                                           X                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                               +  +                                       |             
      Carcinoma                            |                               X                                          |             
      Bilateral, C-Cell, Adenoma           |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              | +              +     +  +           +  +  +     +     +  +  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                     +  +                                 |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                +                       +  +                 +            |             
      Carcinoma                            |                X                                                         |             
                                            __________________________________________________________________________|             
   Prostate                                |    +                                                                     |             
                                            __________________________________________________________________________|             
   Testes                                  |       +                 +        +     +                          +      |             
      Interstitial Cell, Adenoma           |       X                 X        X     X                          X      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +        +                                      +     +   |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   8                                                               
NTP Experiment-Test: 88034-07                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:25:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 6| 7| 5| 4| 5| 7| 6| 6| 4| 7| 6| 6| 7| 5| 5| 5| 6| 6| 6| 6| 5| 5| 6|             
                             DAY ON TEST   | 1| 7| 1| 3| 8| 6| 4| 1| 8| 2| 6| 3| 6| 4| 0| 8| 0| 1| 3| 5| 2| 3| 8| 5| 8|             
                                           | 7| 8| 2| 6| 2| 6| 4| 0| 3| 0| 0| 6| 2| 1| 4| 9| 1| 8| 3| 5| 5| 5| 9| 7| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .1MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    NNK/AIR                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Deep Cervical, Leukemia Mononuclear  |                                                                          |             
      Iliac, Leukemia Mononuclear          |                         X                                                |             
      Renal, Leukemia Mononuclear          |                         X                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  M  M  +  M  M  M  +  +  M  +  +  +  +  +  +  +  M  +  +  M  +  +  +|             
      Leukemia Mononuclear                 |             X           X           X  X  X     X                 X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                         +  +              +     +                        |             
      Leukemia Mononuclear                 |                         X  X              X     X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                +        +                 +     +                        |             
      Leukemia Mononuclear                 |                         X                 X     X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X           X     X  X        X  X  X  X  X                 X      |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +        +      |             
      Leukemia Mononuclear                 |       X     X     X  X  X  X  X     X  X  X  X  X     X  X        X      |             
      Sarcoma                              |                                                          X               |             
                                            __________________________________________________________________________|             
   Thymus                                  |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |          +           +  +                                                |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                                           X                              |             
      Keratoacanthoma, Multiple            |                                                                          |             
      Squamous Cell Papilloma              |                   X                                                      |             
      Subcutaneous Tissue, Fibroma         | X                                                                        |             
      Subcutaneous Tissue, Melanoma Benign |                            X                                             |             
      Subcutaneous Tissue, Skin, Site of   |                                                                          |             
          Application, Sarcoma             |                         X                                               X|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                       X     X            |             
      Leukemia Mononuclear                 |       X     X     X     X     X     X  X  X     X     X           X      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                 X                              |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   9                                                               
NTP Experiment-Test: 88034-07                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:25:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 6| 7| 5| 4| 5| 7| 6| 6| 4| 7| 6| 6| 7| 5| 5| 5| 6| 6| 6| 6| 5| 5| 6|             
                             DAY ON TEST   | 1| 7| 1| 3| 8| 6| 4| 1| 8| 2| 6| 3| 6| 4| 0| 8| 0| 1| 3| 5| 2| 3| 8| 5| 8|             
                                           | 7| 8| 2| 6| 2| 6| 4| 0| 3| 0| 0| 6| 2| 1| 4| 9| 1| 8| 3| 5| 5| 5| 9| 7| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .1MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    NNK/AIR                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |          +  +        +  +  +              +  +        +     +  +         |             
      Leukemia Mononuclear                 |                         X                 X                              |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +                       +                                                |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X     X     X  X  X  X  X     X  X  X  X  X     X  X        X      |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  10                                                               
NTP Experiment-Test: 88034-07                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:25:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 5| 6| 4| 7| 6| 7| 5| 6| 7| 6| 6| 7| 6| 5| 6| 6| 6| 5| 7| 5|     |            |
                             DAY ON TEST   | 7| 3| 1| 5| 9| 4| 0| 1| 1| 0| 6| 3| 1| 3| 3| 7| 2| 3| 7| 4| 5| 3| 5|     |            |
                                           | 9| 6| 5| 5| 7| 4| 4| 7| 6| 1| 3| 6| 3| 9| 6| 3| 9| 5| 1| 1| 1| 6| 0|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   FISCHER 344 RATS MALE                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |     A      |
    .1MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |     L      |
    NNK/AIR                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|     |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                  +                                       |   1        |
      Carcinoma                            |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +        +        +        +  +  +  +  +        +  +  +  +            |  27        |
      Leukemia Mononuclear                 | X  X        X                 X  X        X        X     X  X            |         20 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                +           +           +               |  10        |
      Leukemia Mononuclear                 | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |             +                                +                           |   4        |
      Pharyngeal, Squamous Cell Papilloma  |                                              X                           |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                +                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                       +                  |   1        |
      Squamous Cell Papilloma              |                                                       X                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                   +                          +              +            |   5        |
      Adenoma                              |                                                                          |          2 |
      Carcinoma                            |                   X                          X              X            |          3 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |          +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +     +      |  35        |
      Leukemia Mononuclear                 |                               X                             X            |          3 |
      Pars Distalis, Adenoma               |          X     X  X  X  X        X  X  X  X  X  X  X     X  X     X      |         32 |
      Pars Distalis, Leukemia Mononuclear  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |   2        |
      Carcinoma                            |                                                                          |          1 |
      Bilateral, C-Cell, Adenoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peritoneum                              | +        +           +  +  +  +     +  +  +  +        +                  |  24        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Penis                                   |             +                                      +                     |   4        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                            +                 +                           |   6        |
      Carcinoma                            |                                              X                           |          2 |
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                    +                     |   2        |
                                            __________________________________________________________________________|____________|
   Testes                                  |    +  +                 +                                      +         |   9        |
      Interstitial Cell, Adenoma           |    X  X                 X                                      X         |          9 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  11                                                               
NTP Experiment-Test: 88034-07                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:25:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 5| 6| 4| 7| 6| 7| 5| 6| 7| 6| 6| 7| 6| 5| 6| 6| 6| 5| 7| 5|     |            |
                             DAY ON TEST   | 7| 3| 1| 5| 9| 4| 0| 1| 1| 0| 6| 3| 1| 3| 3| 7| 2| 3| 7| 4| 5| 3| 5|     |            |
                                           | 9| 6| 5| 5| 7| 4| 4| 7| 6| 1| 3| 6| 3| 9| 6| 3| 9| 5| 1| 1| 1| 6| 0|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   FISCHER 344 RATS MALE                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |     A      |
    .1MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |     L      |
    NNK/AIR                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|     |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                               +                                          |   1        |
      Leukemia Mononuclear                 |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                             +                             +            |   7        |
      Leukemia Mononuclear                 | X                             X                                          |          2 |
      Deep Cervical, Leukemia Mononuclear  |                               X                                          |          1 |
      Iliac, Leukemia Mononuclear          |                               X                                          |          2 |
      Renal, Leukemia Mononuclear          |                               X                             X            |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  M  M  +  +  +  M  +  +  +  M  +  M  M  +     +  +  +  +      |  32        |
      Leukemia Mononuclear                 | X  X                          X           X        X        X            |         13 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +     +                       +                             +            |   8        |
      Leukemia Mononuclear                 | X                             X                             X            |          7 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +                       +  +                                          |   8        |
      Leukemia Mononuclear                 | X  X                       X  X                                          |          7 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  M  I  M  +  +  M  +  M  +  +  +  +  +  +  +  M  I      |  37        |
      Leukemia Mononuclear                 | X           X              X  X           X                 X            |         16 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +     +     +     +  +  +  +        +  +     +     +  +  +         |  32        |
      Leukemia Mononuclear                 | X  X        X              X  X  X        X        X     X  X            |         25 |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                               +                                          |   1        |
      Leukemia Mononuclear                 |                               X                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +                                      +                              |   5        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Keratoacanthoma                      |       X                                                                  |          2 |
      Keratoacanthoma, Multiple            |                                                                X         |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                   X                          X           X               |          4 |
      Subcutaneous Tissue, Melanoma Benign |                                                                          |          1 |
      Subcutaneous Tissue, Skin, Site of   |                                                                          |            |
          Application, Sarcoma             |       X                          X                                       |          4 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  12                                                               
NTP Experiment-Test: 88034-07                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:25:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 5| 6| 4| 7| 6| 7| 5| 6| 7| 6| 6| 7| 6| 5| 6| 6| 6| 5| 7| 5|     |            |
                             DAY ON TEST   | 7| 3| 1| 5| 9| 4| 0| 1| 1| 0| 6| 3| 1| 3| 3| 7| 2| 3| 7| 4| 5| 3| 5|     |            |
                                           | 9| 6| 5| 5| 7| 4| 4| 7| 6| 1| 3| 6| 3| 9| 6| 3| 9| 5| 1| 1| 1| 6| 0|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   FISCHER 344 RATS MALE                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |     A      |
    .1MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |     L      |
    NNK/AIR                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|     |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          2 |
      Leukemia Mononuclear                 | X           X              X  X           X        X        X            |         18 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +  +  +        +  +     +  +  +  +  +  +                 +         |  22        |
      Leukemia Mononuclear                 |                               X                                          |          3 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |   2        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Leukemia Mononuclear                 | X  X        X              X  X  X        X        X     X  X            |         25 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  13                                                               
NTP Experiment-Test: 88034-07                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:25:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 6| 7| 6| 6| 5| 7| 7| 5| 6| 6| 6| 4| 5| 6| 6| 6| 5| 6| 6| 7| 5| 6|             
                             DAY ON TEST   | 6| 5| 0| 7| 3| 8| 6| 2| 3| 1| 2| 1| 3| 6| 2| 9| 0| 8| 8| 7| 0| 9| 3| 4| 0|             
                                           | 2| 1| 3| 8| 6| 3| 3| 8| 6| 5| 9| 7| 9| 1| 9| 0| 3| 3| 7| 9| 4| 5| 6| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    NNK/AIR                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +                                                                        |             
      Leukemia Mononuclear                 | X                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +                                                                  |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +|             
      Hepatocellular Adenoma               |                                                                          |             
      Leukemia Mononuclear                 | X  X  X  X  X  X     X  X  X     X     X     X  X  X  X  X  X  X        X|             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                       +                 +        +                  |             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Pancreas                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                                                                         +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +                                                                 +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |                            +           +        +                        |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |                                                                          |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                                                                          |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +     +  +  +  +  +     +  +  +  +  +  +  M  +        +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |    X     X  X  X  X  X     X  X  X  X  X  X     X        X  X     X  X  X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                   +                                                      |             
      C-Cell, Carcinoma                    |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |    +  +  +     +  +  +  +        +  +  +  +  +  +  +     +     +  +      |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |       +                             +  +                                +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +        +                 +     +                                +   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |          +        +                 +              +  +  +              +|             
      Interstitial Cell, Adenoma           |          X                          X              X  X  X              X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +  +  +     +                 +        +  +     +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                 X                        |             
      Deep Cervical, Leukemia Mononuclear  |       X  X                                                               |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  14                                                               
NTP Experiment-Test: 88034-07                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:25:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 6| 7| 6| 6| 5| 7| 7| 5| 6| 6| 6| 4| 5| 6| 6| 6| 5| 6| 6| 7| 5| 6|             
                             DAY ON TEST   | 6| 5| 0| 7| 3| 8| 6| 2| 3| 1| 2| 1| 3| 6| 2| 9| 0| 8| 8| 7| 0| 9| 3| 4| 0|             
                                           | 2| 1| 3| 8| 6| 3| 3| 8| 6| 5| 9| 7| 9| 1| 9| 0| 3| 3| 7| 9| 4| 5| 6| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    NNK/AIR                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Iliac, Leukemia Mononuclear          |          X                                                               |             
      Pancreatic, Leukemia Mononuclear     | X           X                          X           X                    X|             
      Renal, Leukemia Mononuclear          | X     X        X                       X                 X               |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  M  M  M  M  M  M  +  +  M  +  I  +  +  +  +  M  M  M  M  M  +|             
      Leukemia Mononuclear                 | X     X  X                             X     X     X  X                 X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +  +     +              +     +  +                    +           +|             
      Leukemia Mononuclear                 | X     X  X     X                       X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |          +                             +                 +               |             
      Leukemia Mononuclear                 |          X                             X                 X               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X  X  X                 X     X     X  X     X  X  X           X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X  X  X  X     X  X  X     X     X     X  X  X  X     X  X  X     X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +                                                  +                     |             
      Leukemia Mononuclear                 | X                                                  X                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |             +        +                          +                        |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |          X                                                               |             
      Trichoepithelioma                    |                                                                X         |             
      Sebaceous Gland, Adenoma             |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Skin, Site of   |                                                                          |             
          Application, Sarcoma             |    X                 X     X                                         X   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                         X        X                 X        X  X  X      |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |    X        X     X        X              X  X  X        X               |             
      Alveolar/Bronchiolar Carcinoma       |          X              X  X           X        X  X                     |             
      Leukemia Mononuclear                 | X     X  X     X                       X     X  X  X  X                 X|             
      Sarcoma, Metastatic, Skin            |    X                                                                     |             
      Squamous Cell Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X                                                               |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  15                                                               
NTP Experiment-Test: 88034-07                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:25:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 6| 7| 6| 6| 5| 7| 7| 5| 6| 6| 6| 4| 5| 6| 6| 6| 5| 6| 6| 7| 5| 6|             
                             DAY ON TEST   | 6| 5| 0| 7| 3| 8| 6| 2| 3| 1| 2| 1| 3| 6| 2| 9| 0| 8| 8| 7| 0| 9| 3| 4| 0|             
                                           | 2| 1| 3| 8| 6| 3| 3| 8| 6| 5| 9| 7| 9| 1| 9| 0| 3| 3| 7| 9| 4| 5| 6| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    NNK/AIR                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Respiratory Epithelium, Adenoma      |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +        +  +  +        +           +  +        +     +     +  +     +|             
      Leukemia Mononuclear                 | X              X                                                         |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                 +                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X  X  X  X  X     X  X  X     X     X     X  X  X  X  X  X  X  X     X|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  16                                                               
NTP Experiment-Test: 88034-07                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:25:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 6| 6| 7| 4| 5| 4| 7| 5| 5| 4| 6| 4| 6| 6| 6| 5| 6| 5| 5| 6|     |            |
                             DAY ON TEST   | 8| 4| 0| 0| 0| 1| 8| 4| 5| 3| 9| 3| 8| 9| 8| 7| 8| 0| 8| 6| 5| 8| 4|     |            |
                                           | 3| 5| 4| 3| 5| 2| 6| 0| 0| 6| 0| 3| 9| 5| 8| 7| 3| 5| 3| 9| 0| 3| 1|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   FISCHER 344 RATS MALE                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |     A      |
    1 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |     L      |
    NNK/AIR                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|     |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                   +           A                                          |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |   1        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +        +        +  +  +  +  +  +  +  +            |  39        |
      Hepatocellular Adenoma               |             X                                                            |          1 |
      Leukemia Mononuclear                 | X  X  X  X  X  X  X  X        X           X  X  X  X  X  X  X            |         35 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +     +     +        +                              |   8        |
      Leukemia Mononuclear                 |                      X     X                                             |          3 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                     +                                    |   1        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                       +                  |   3        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |                                        +                                 |   4        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |                                              +                           |   1        |
      Pheochromocytoma Benign              |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                        +                                 |   1        |
      Carcinoma                            |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +  +  +  +  +        +  +  +  +  +  +     +  +           +  +      |  34        |
      Leukemia Mononuclear                 | X     X           X                                                      |          3 |
      Pars Distalis, Adenoma               |          X  X  X  X        X  X  X  X  X        X  X           X  X      |         31 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |   1        |
      C-Cell, Carcinoma                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peritoneum                              | +  +  +  +  +  +        +  +           +  +  +     +     +  +     +      |  32        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                   +      |   5        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                           +     +  +                     |   9        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +                                                                        |   1        |
      Leukemia Mononuclear                 | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  |       +                    +           +     +  +        +               |  13        |
      Interstitial Cell, Adenoma           |       X                    X           X     X  X        X               |         12 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  17                                                               
NTP Experiment-Test: 88034-07                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:25:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 6| 6| 7| 4| 5| 4| 7| 5| 5| 4| 6| 4| 6| 6| 6| 5| 6| 5| 5| 6|     |            |
                             DAY ON TEST   | 8| 4| 0| 0| 0| 1| 8| 4| 5| 3| 9| 3| 8| 9| 8| 7| 8| 0| 8| 6| 5| 8| 4|     |            |
                                           | 3| 5| 4| 3| 5| 2| 6| 0| 0| 6| 0| 3| 9| 5| 8| 7| 3| 5| 3| 9| 0| 3| 1|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   FISCHER 344 RATS MALE                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |     A      |
    1 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |     L      |
    NNK/AIR                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|     |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +     +  +        +           +  +  +        +     +            |  26        |
      Leukemia Mononuclear                 |                                           X                              |          2 |
      Deep Cervical, Leukemia Mononuclear  |                                                                          |          2 |
      Iliac, Leukemia Mononuclear          |                                           X                              |          2 |
      Pancreatic, Leukemia Mononuclear     |    X     X     X  X        X              X           X     X            |         13 |
      Renal, Leukemia Mononuclear          | X  X  X                    X              X           X     X            |         12 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  +  +  +  +  M  +  +  M  +  M  +  M  +  +  +  +  +  M  M      |  28        |
      Leukemia Mononuclear                 | X  X  X        X  X  X     X              X     X  X  X  X  X            |         21 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +     +           +  +                    +                              |  14        |
      Leukemia Mononuclear                 | X     X           X  X                    X                              |         10 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +        +     +     +                    +                 +            |   9        |
      Leukemia Mononuclear                 | X        X     X     X                    X                 X            |          9 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +      |  45        |
      Leukemia Mononuclear                 | X  X  X  X     X  X  X     X              X  X     X  X  X  X            |         26 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +     +  +           +  +  +  +  +  +  +            |  39        |
      Leukemia Mononuclear                 | X  X  X  X  X  X  X  X     X  X           X  X  X  X  X  X  X            |         35 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                      +                                                   |   3        |
      Leukemia Mononuclear                 |                      X                                                   |          3 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +                                   +                                 |   5        |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Keratoacanthoma                      |       X                                                                  |          2 |
      Trichoepithelioma                    |                                                                          |          1 |
      Sebaceous Gland, Adenoma             |       X                                                                  |          1 |
      Subcutaneous Tissue, Fibroma         |                         X                                                |          1 |
      Subcutaneous Tissue, Skin, Site of   |                                                                          |            |
          Application, Sarcoma             |       X                                                                  |          5 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                        +                                 |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  18                                                               
NTP Experiment-Test: 88034-07                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:25:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 6| 6| 7| 4| 5| 4| 7| 5| 5| 4| 6| 4| 6| 6| 6| 5| 6| 5| 5| 6|     |            |
                             DAY ON TEST   | 8| 4| 0| 0| 0| 1| 8| 4| 5| 3| 9| 3| 8| 9| 8| 7| 8| 0| 8| 6| 5| 8| 4|     |            |
                                           | 3| 5| 4| 3| 5| 2| 6| 0| 0| 6| 0| 3| 9| 5| 8| 7| 3| 5| 3| 9| 0| 3| 1|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   FISCHER 344 RATS MALE                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |     A      |
    1 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |     L      |
    NNK/AIR                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|     |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Alveolar/Bronchiolar Adenoma         |    X                             X           X           X        X      |         11 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |       X                                                                  |          9 |
      Alveolar/Bronchiolar Carcinoma       | X     X                                                                  |          8 |
      Leukemia Mononuclear                 | X  X  X           X  X     X              X        X  X     X            |         20 |
      Sarcoma, Metastatic, Skin            |                                                                          |          1 |
      Squamous Cell Carcinoma              |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Respiratory Epithelium, Adenoma      | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +           +           +     +  +           +            |  24        |
      Leukemia Mononuclear                 | X     X                    X                    X           X            |          7 |
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                        +                                 |   1        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Leukemia Mononuclear                 | X  X  X  X  X  X  X  X     X  X           X  X  X  X  X  X  X            |         37 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  19                                                               
NTP Experiment-Test: 88034-07                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:25:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 4| 4| 6| 6| 5| 6| 6| 3| 3| 1| 7| 6| 5| 7| 7| 5| 5| 5| 6| 7| 6| 6|             
                             DAY ON TEST   | 2| 5| 0| 5| 4| 3| 6| 0| 7| 7| 8| 3| 9| 1| 2| 8| 3| 0| 2| 9| 1| 4| 0| 1| 1|             
                                           | 5| 6| 3| 8| 0| 6| 9| 2| 8| 3| 9| 3| 2| 2| 4| 9| 6| 9| 3| 2| 5| 5| 4| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    TRIOCT./                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    OZONE                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +              +        +  +           +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X              X        X              X  X     X        X     X         |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +              +                                   +           +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Sarcoma                              |                                                                         X|             
      Sarcoma, Metastatic, Tissue NOS      |       X                                                                  |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                       +                  |             
                                            __________________________________________________________________________|             
   Pancreas                                |          +                                                               |             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                                                    +                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                    +                     |             
                                            __________________________________________________________________________|             
   Heart                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |                                                    +           +        +|             
      Adenoma                              |                                                                X         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                                                                   +      |             
      Carcinoma                            |                                                                   X      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +           +  +  M  +  +                    +        +        +  +|             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Tissue NOS                      |                                                                          |             
      Pars Distalis, Adenoma               | X  X  X           X  X     X  X                    X        X        X  X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |                +  +     +  +  +        +  +        +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tissue NOS                              |       +     +  +                                +                 +      |             
      Sarcoma                              |       X     X  X                                X                        |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                         +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                      +     +                    +           +        +   |             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |                   +                                                      |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +           +     +                    +  +  +     +        +     +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  20                                                               
NTP Experiment-Test: 88034-07                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:25:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 4| 4| 6| 6| 5| 6| 6| 3| 3| 1| 7| 6| 5| 7| 7| 5| 5| 5| 6| 7| 6| 6|             
                             DAY ON TEST   | 2| 5| 0| 5| 4| 3| 6| 0| 7| 7| 8| 3| 9| 1| 2| 8| 3| 0| 2| 9| 1| 4| 0| 1| 1|             
                                           | 5| 6| 3| 8| 0| 6| 9| 2| 8| 3| 9| 3| 2| 2| 4| 9| 6| 9| 3| 2| 5| 5| 4| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    TRIOCT./                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    OZONE                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Interstitial Cell, Adenoma           | X  X                    X                    X  X  X     X        X      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                        +                 +     +         |             
      Iliac, Leukemia Mononuclear          |                                                                X         |             
      Pancreatic, Leukemia Mononuclear     |                                        X                       X         |             
      Renal, Leukemia Mononuclear          |                                                                X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  M  M  +  +  +  +  M  +  +  +  +  M  +  M  +  +  M  +  M  +  M  M  M  +|             
      Leukemia Mononuclear                 |          X     X  X           X        X        X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                                                             +            |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  I  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  M  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X        X     X     X  X              X  X     X        X     X         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +        +     +  +  +  +  +  +        +  +     +  +     +     +  +     +|             
      Leukemia Mononuclear                 | X        X     X  X  X  X     X        X  X     X        X     X         |             
                                            __________________________________________________________________________|             
   Thymus                                  |          +                                                               |             
      Leukemia Mononuclear                 |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                      +                                                   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                   X  X  X                                                |             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                            X                                             |             
      Subcutaneous Tissue, Skin, Site of   |                                                                          |             
          Application, Sarcoma             | X  X                                   X     X                           |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Cranial Nerve, Schwannoma Malignant  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Leukemia Mononuclear                 | X        X     X  X  X        X        X  X     X              X         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pleura                                  |             +                                                            |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  21                                                               
NTP Experiment-Test: 88034-07                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:25:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 4| 4| 6| 6| 5| 6| 6| 3| 3| 1| 7| 6| 5| 7| 7| 5| 5| 5| 6| 7| 6| 6|             
                             DAY ON TEST   | 2| 5| 0| 5| 4| 3| 6| 0| 7| 7| 8| 3| 9| 1| 2| 8| 3| 0| 2| 9| 1| 4| 0| 1| 1|             
                                           | 5| 6| 3| 8| 0| 6| 9| 2| 8| 3| 9| 3| 2| 2| 4| 9| 6| 9| 3| 2| 5| 5| 4| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    TRIOCT./                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    OZONE                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
      Sarcoma, Metastatic, Tissue NOS      |             X                                                            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |          +              +                          +     +  +     +  +   |             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X        X     X  X  X  X     X        X  X     X        X     X         |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  22                                                               
NTP Experiment-Test: 88034-07                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:25:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 6| 6| 7| 7| 5| 5| 6| 6| 6| 6| 2| 6| 6| 7| 5| 7| 5| 6| 5| 4|     |            |
                             DAY ON TEST   | 3| 9| 0| 3| 9| 3| 0| 8| 5| 6| 5| 3| 3| 5| 3| 1| 2| 3| 1| 2| 3| 6| 8|     |            |
                                           | 6| 0| 5| 5| 4| 6| 5| 0| 0| 1| 9| 4| 4| 3| 1| 4| 2| 7| 8| 9| 5| 0| 7|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   FISCHER 344 RATS MALE                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|     |     A      |
    TRIOCT./                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |     L      |
    OZONE                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|     |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                      A                                                   |            |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +           +  +  +  +     +  +        +  +           +  +  +      |  28        |
      Leukemia Mononuclear                 |       X           X  X     X     X  X        X              X  X  X      |         18 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                     +           +              +         |   8        |
      Leukemia Mononuclear                 |                                                                X         |          1 |
      Sarcoma                              |                                                                          |          1 |
      Sarcoma, Metastatic, Tissue NOS      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |   1        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                +         |   2        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                 +              +         |   3        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                             +            |   1        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |                                                                          |   3        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +     +  +         |  29        |
      Schwannoma Malignant, Metastatic,    |                                                                          |            |
           Tissue NOS                      |                                        X                                 |          1 |
      Pars Distalis, Adenoma               |    X  X  X  X  X  X     X  X  X  X  X     X     X  X  X     X  X         |         28 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peritoneum                              |    +  +  +  +  +  +  +  +  +     +  +     +  +           +  +  +         |  30        |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   5        |
      Sarcoma                              |                                                                          |          4 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                    +        +            |   3        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |             +              +                                      +      |   8        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  23                                                               
NTP Experiment-Test: 88034-07                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:25:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 6| 6| 7| 7| 5| 5| 6| 6| 6| 6| 2| 6| 6| 7| 5| 7| 5| 6| 5| 4|     |            |
                             DAY ON TEST   | 3| 9| 0| 3| 9| 3| 0| 8| 5| 6| 5| 3| 3| 5| 3| 1| 2| 3| 1| 2| 3| 6| 8|     |            |
                                           | 6| 0| 5| 5| 4| 6| 5| 0| 0| 1| 9| 4| 4| 3| 1| 4| 2| 7| 8| 9| 5| 0| 7|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   FISCHER 344 RATS MALE                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|     |     A      |
    TRIOCT./                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |     L      |
    OZONE                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|     |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Adenoma                              |                                                                   X      |          1 |
      Leukemia Mononuclear                 |                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +     +        +  +  +     +     +        +  +  +        +  +  +         |  24        |
      Leukemia Mononuclear                 |                                                                X         |          1 |
      Interstitial Cell, Adenoma           | X     X        X  X  X     X     X        X  X  X        X  X            |         20 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                      +  +        +  +     +                    +  +      |  10        |
      Iliac, Leukemia Mononuclear          |                                  X                                       |          2 |
      Pancreatic, Leukemia Mononuclear     |                      X                                         X  X      |          5 |
      Renal, Leukemia Mononuclear          |                                     X                             X      |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  M  M  +  +  M  M  M  M  +  +  +  M  +  M  M  M  M  M  +  M  +  +      |  23        |
      Leukemia Mononuclear                 |             X              X  X  X                             X  X      |         12 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +                 +  +        +                 +           +         |   7        |
      Leukemia Mononuclear                 |                      X           X                                       |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                  +  +                             +      |   3        |
      Leukemia Mononuclear                 |                                  X                                X      |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +      |  43        |
      Leukemia Mononuclear                 |       X     X        X     X     X  X                          X  X      |         18 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +  +  +  +  +  +     +  +  +  +     +     +     +     +  +  +      |  33        |
      Leukemia Mononuclear                 |       X     X  X  X  X     X  X  X  X                       X  X  X      |         24 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |   1        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                     +                                    |   2        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Keratoacanthoma                      |                                                          X               |          4 |
      Squamous Cell Papilloma              |             X                                                            |          1 |
      Subcutaneous Tissue, Fibroma         |                                                          X               |          2 |
      Subcutaneous Tissue, Skin, Site of   |                                                                          |            |
          Application, Sarcoma             |                                                    X                     |          5 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                        +                       +         |   2        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  24                                                               
NTP Experiment-Test: 88034-07                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:25:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 6| 6| 7| 7| 5| 5| 6| 6| 6| 6| 2| 6| 6| 7| 5| 7| 5| 6| 5| 4|     |            |
                             DAY ON TEST   | 3| 9| 0| 3| 9| 3| 0| 8| 5| 6| 5| 3| 3| 5| 3| 1| 2| 3| 1| 2| 3| 6| 8|     |            |
                                           | 6| 0| 5| 5| 4| 6| 5| 0| 0| 1| 9| 4| 4| 3| 1| 4| 2| 7| 8| 9| 5| 0| 7|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   FISCHER 344 RATS MALE                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|     |     A      |
    TRIOCT./                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |     L      |
    OZONE                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|     |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                                                                X         |          1 |
      Cranial Nerve, Schwannoma Malignant  |                                        X                                 |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Alveolar/Bronchiolar Adenoma         |    X                                                                     |          1 |
      Leukemia Mononuclear                 |       X     X     X  X     X  X  X  X                       X  X  X      |         21 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Pleura                                  |                                                 +                        |   2        |
      Mesothelioma Malignant               |                                                 X                        |          1 |
      Sarcoma, Metastatic, Tissue NOS      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |       +                                                                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +        +  +  +  +                       +     +     +                  |  15        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                      +                             +                     |   2        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Leukemia Mononuclear                 |       X     X  X  X  X     X  X  X  X        X              X  X  X      |         25 |
      Mesothelioma Malignant               |                                                 X                        |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  25                                                               
NTP Experiment-Test: 88034-07                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:25:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 7| 6| 4| 6| 6| 6| 5| 5| 2| 7| 6| 6| 6| 5| 5| 5| 4| 6| 5| 7| 6|             
                             DAY ON TEST   | 3| 0| 7| 4| 3| 9| 6| 7| 9| 6| 8| 6| 3| 1| 0| 6| 8| 6| 5| 6| 4| 8| 5| 1| 6|             
                                           | 6| 4| 3| 9| 6| 7| 0| 1| 8| 9| 3| 9| 4| 0| 5| 2| 3| 7| 0| 5| 4| 0| 2| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    .1M/KNNK                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    /OZONE                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                                             +            |             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                                                       +                  |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +     +     +|             
      Leukemia Mononuclear                 |    X  X  X  X  X  X     X     X  X     X  X        X  X     X     X     X|             
                                            __________________________________________________________________________|             
   Mesentery                               |       +  +                    +                       +     +            |             
      Leukemia Mononuclear                 |          X                    X                       X                  |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                      +                                                   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                                                    +                     |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |          +                                                               |             
      Leukemia Mononuclear                 |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |                               +                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                            +                                             |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |             +     +  +  +  +           +  +  +  +     +        +     +   |             
      Leukemia Mononuclear                 |                   X     X                 X                              |             
      Pars Distalis, Adenoma               |             X        X     X           X     X  X     X        X     X   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              | +  +  +  +     +     +     +     +     +  +           +     +  +  +     +|             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                  +                                       |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                    +                     |             
                                            __________________________________________________________________________|             
   Prostate                                |                         +                                                |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +        +     +  +  +     +        +  +                    +     +|             
      Leukemia Mononuclear                 |       X                                                                  |             
      Mesothelioma Malignant               |                                                                          |             
      Interstitial Cell, Adenoma           | X  X  X        X     X  X  X     X        X                       X     X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                         +                                                |             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +     +        +     +  +     +                    +     +            |             
      Leukemia Mononuclear                 |          X                                                  X            |             
      Deep Cervical, Leukemia Mononuclear  |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  26                                                               
NTP Experiment-Test: 88034-07                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:25:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 7| 6| 4| 6| 6| 6| 5| 5| 2| 7| 6| 6| 6| 5| 5| 5| 4| 6| 5| 7| 6|             
                             DAY ON TEST   | 3| 0| 7| 4| 3| 9| 6| 7| 9| 6| 8| 6| 3| 1| 0| 6| 8| 6| 5| 6| 4| 8| 5| 1| 6|             
                                           | 6| 4| 3| 9| 6| 7| 0| 1| 8| 9| 3| 9| 4| 0| 5| 2| 3| 7| 0| 5| 4| 0| 2| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    .1M/KNNK                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    /OZONE                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Iliac, Leukemia Mononuclear          |                   X                                                      |             
      Pancreatic, Leukemia Mononuclear     |                         X                                                |             
      Renal, Leukemia Mononuclear          |          X                       X                    X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  +  +  M  M  +  +  +  M  M  +  M  M  +  M  +  M  +  M  +  +  +  +  M|             
      Leukemia Mononuclear                 |          X        X     X        X        X           X     X  X     X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |          +        +              +                    +     +        +   |             
      Leukemia Mononuclear                 |          X        X              X                    X     X        X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +  +        +     +     +  +        +        +        +        +   |             
      Leukemia Mononuclear                 |       X  X        X     X     X  X        X        X        X        X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X     X        X     X     X  X        X     X  X  X     X  X     X  X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +     +  +     +  +        +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X  X  X  X  X  X  X     X  X     X  X        X  X     X  X  X  X  X|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |          +        +           +                                          |             
      Leukemia Mononuclear                 |          X        X           X                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Adenoma                   |                         X                                                |             
      Keratoacanthoma                      |                                                                          |             
      Subcutaneous Tissue, Skin, Site of   |                                                                          |             
          Application, Sarcoma             |    X                                X                                    |             
      Subcutaneous Tissue, Skin, Site of   |                                                                          |             
          Application, Sarcoma, Multiple   |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |             X                                            X               |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Leukemia Mononuclear                 |    X  X  X     X  X     X     X  X        X        X  X     X  X     X   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  27                                                               
NTP Experiment-Test: 88034-07                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:25:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 7| 6| 4| 6| 6| 6| 5| 5| 2| 7| 6| 6| 6| 5| 5| 5| 4| 6| 5| 7| 6|             
                             DAY ON TEST   | 3| 0| 7| 4| 3| 9| 6| 7| 9| 6| 8| 6| 3| 1| 0| 6| 8| 6| 5| 6| 4| 8| 5| 1| 6|             
                                           | 6| 4| 3| 9| 6| 7| 0| 1| 8| 9| 3| 9| 4| 0| 5| 2| 3| 7| 0| 5| 4| 0| 2| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    .1M/KNNK                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    /OZONE                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |          +  +           +  +           +     +  +           +            |             
      Leukemia Mononuclear                 |          X              X                                   X            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                                          +  +            |             
      Leukemia Mononuclear                 |                                                             X            |             
      Papilloma                            |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X  X  X  X  X  X  X     X  X     X  X     X  X  X     X  X  X  X  X|             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  28                                                               
NTP Experiment-Test: 88034-07                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:25:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 7| 6| 6| 5| 4| 7| 4| 5| 6| 6| 6| 7| 6| 7| 7| 6| 7| 4| 6|     |            |
                             DAY ON TEST   | 8| 1| 3| 2| 3| 3| 6| 7| 9| 3| 4| 6| 4| 3| 0| 0| 8| 3| 3| 3| 2| 1| 8|     |            |
                                           | 1| 3| 6| 0| 3| 5| 9| 5| 6| 6| 4| 7| 1| 8| 4| 3| 3| 6| 6| 2| 5| 6| 3|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   FISCHER 344 RATS MALE                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |     A      |
    .1M/KNNK                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |     L      |
    /OZONE                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|     |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |   1        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +  +     +        +  +     +  +  +  +  +  +  +     +  +     +      |  36        |
      Leukemia Mononuclear                 |    X  X        X        X  X     X  X  X  X  X  X  X        X     X      |         30 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +  +                       +     +        +           +            |  11        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Sarcoma                              |          X                       X                                       |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                               +                                          |   2        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +  +  +  +  +        +        +  +  +     +     +  +  +  +  +      |  27        |
      Leukemia Mononuclear                 |                                        X                                 |          4 |
      Pars Distalis, Adenoma               |       X  X  X  X  X        X        X     X     X     X  X  X  X  X      |         23 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peritoneum                              | +  +  +           +        +  +     +     +  +  +  +  +  +  +  +  +      |  31        |
      Mesothelioma Malignant               |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                   +                                                      |   1        |
      Mesothelioma Malignant               |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                          +               |   2        |
                                            __________________________________________________________________________|____________|
   Prostate                                |             +                                                            |   2        |
                                            __________________________________________________________________________|____________|
   Testes                                  |       +  +  +     +  +     +     +  +  +     +     +  +     +            |  25        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                   X                                                      |          1 |
      Interstitial Cell, Adenoma           |       X  X  X     X        X     X  X  X     X     X  X     X            |         23 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  29                                                               
NTP Experiment-Test: 88034-07                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:25:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 7| 6| 6| 5| 4| 7| 4| 5| 6| 6| 6| 7| 6| 7| 7| 6| 7| 4| 6|     |            |
                             DAY ON TEST   | 8| 1| 3| 2| 3| 3| 6| 7| 9| 3| 4| 6| 4| 3| 0| 0| 8| 3| 3| 3| 2| 1| 8|     |            |
                                           | 1| 3| 6| 0| 3| 5| 9| 5| 6| 6| 4| 7| 1| 8| 4| 3| 3| 6| 6| 2| 5| 6| 3|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   FISCHER 344 RATS MALE                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |     A      |
    .1M/KNNK                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |     L      |
    /OZONE                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|     |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |   1        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                               +                    +                     |  10        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Deep Cervical, Leukemia Mononuclear  |                                                                          |          1 |
      Iliac, Leukemia Mononuclear          |                                                                          |          1 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          1 |
      Renal, Leukemia Mononuclear          |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  M  +  +  +  M  M  M  M  +  +  +  I  +  +  +  M  M  M  +  M  M      |  26        |
      Leukemia Mononuclear                 |    X                                                                     |         10 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                  +                                       |   7        |
      Leukemia Mononuclear                 |                                                                          |          6 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                    +                     |  11        |
      Leukemia Mononuclear                 |                                                    X                     |         11 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  M  +  M  +      |  43        |
      Leukemia Mononuclear                 |    X  X        X                 X  X  X           X                     |         21 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +        +  +  +  +  +     +  +  +  +  +  +  +  +     +     +      |  37        |
      Leukemia Mononuclear                 |    X  X        X        X  X     X  X  X  X  X  X  X  X     X     X      |         34 |
      Mesothelioma Malignant               |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |   3        |
      Leukemia Mononuclear                 |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Basal Cell Adenoma                   |                                                                          |          1 |
      Keratoacanthoma                      |                                  X                             X         |          2 |
      Subcutaneous Tissue, Skin, Site of   |                                                                          |            |
          Application, Sarcoma             |             X                                   X           X            |          5 |
      Subcutaneous Tissue, Skin, Site of   |                                                                          |            |
          Application, Sarcoma, Multiple   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  30                                                               
NTP Experiment-Test: 88034-07                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:25:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 7| 6| 6| 5| 4| 7| 4| 5| 6| 6| 6| 7| 6| 7| 7| 6| 7| 4| 6|     |            |
                             DAY ON TEST   | 8| 1| 3| 2| 3| 3| 6| 7| 9| 3| 4| 6| 4| 3| 0| 0| 8| 3| 3| 3| 2| 1| 8|     |            |
                                           | 1| 3| 6| 0| 3| 5| 9| 5| 6| 6| 4| 7| 1| 8| 4| 3| 3| 6| 6| 2| 5| 6| 3|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   FISCHER 344 RATS MALE                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |     A      |
    .1M/KNNK                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |     L      |
    /OZONE                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|     |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          2 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |       X                                                                  |          1 |
      Leukemia Mononuclear                 |    X  X        X        X              X           X                     |         20 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          | +                    +                                            +      |   3        |
      Carcinoma                            | X                    X                                            X      |          3 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +     +           +  +  +     +     +     +        +  +     +      |  20        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |             +                                                            |   3        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Papilloma                            |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Leukemia Mononuclear                 |    X  X        X        X  X     X  X  X  X  X  X  X  X     X     X      |         35 |
      Mesothelioma Malignant               |                   X                                                      |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  31                                                               
NTP Experiment-Test: 88034-07                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:25:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 5| 2| 4| 7| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 4| 6| 6| 6| 7| 6| 5|             
                             DAY ON TEST   | 1| 6| 5| 5| 5| 5| 3| 8| 4| 0| 0| 8| 8| 6| 3| 4| 1| 5| 7| 9| 6| 4| 2| 8| 9|             
                                           | 7| 2| 8| 7| 3| 6| 6| 3| 1| 3| 3| 7| 3| 9| 6| 0| 0| 5| 0| 7| 1| 0| 5| 3| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    1M/K NNK                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    /OZONE                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |          +                                                               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +     +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X  X           X  X  X  X  X  X  X  X  X  X  X        X     X  X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +        +                             +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                        +                 +               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |                                                 +                        |             
      Pheochromocytoma Malignant           |                                                 X                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                                                                      +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +     +  +        +     +  +        +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |    X  X  X     X  X        X     X  X        X  X  X     X  X  X  X     X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                                                                          |             
      C-Cell, Adenoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |          +     +  +  +  +     +  +              +  +     +     +     +  +|             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Abdominal, Osteosarcoma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                    +                     |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                +                                                         |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +              +                 +  +  +     +  +        +     +      |             
      Interstitial Cell, Adenoma           | X  X              X                 X  X  X     X  X        X     X      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +                    +        +              +              +  +|             
      Leukemia Mononuclear                 |                                        X              X                  |             
      Deep Cervical, Leukemia Mononuclear  |                                        X                                 |             
      Iliac, Leukemia Mononuclear          |                                                                      X   |             
      Inguinal, Leukemia Mononuclear       |                                                                          |             
      Lumbar, Leukemia Mononuclear         |                                                       X                  |             
      Pancreatic, Leukemia Mononuclear     |          X                                                           X   |             
      Renal, Leukemia Mononuclear          |                               X                       X              X  X|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  +  +  +  +  +  M  +  M  +  +  +  +  M  +  +  +  +  M  +  M  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  32                                                               
NTP Experiment-Test: 88034-07                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:25:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 5| 2| 4| 7| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 4| 6| 6| 6| 7| 6| 5|             
                             DAY ON TEST   | 1| 6| 5| 5| 5| 5| 3| 8| 4| 0| 0| 8| 8| 6| 3| 4| 1| 5| 7| 9| 6| 4| 2| 8| 9|             
                                           | 7| 2| 8| 7| 3| 6| 6| 3| 1| 3| 3| 7| 3| 9| 6| 0| 0| 5| 0| 7| 1| 0| 5| 3| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    1M/K NNK                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    /OZONE                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Metastatic, Lung                 |                   X                                                      |             
      Leukemia Mononuclear                 | X     X  X        X     X     X  X  X  X     X                    X  X   |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Lung                            |                   X                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                            +  +  +     +              +           +  +  +|             
      Leukemia Mononuclear                 |                               X  X     X              X           X  X  X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                   +                    +                             +   |             
      Leukemia Mononuclear                 |                   X                    X                             X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  M  +  M  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                   X                                                      |             
      Leukemia Mononuclear                 | X     X           X           X  X  X  X              X     X     X  X   |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Lung                            |                   X                                                      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +           +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X           X  X  X  X  X  X  X  X  X  X     X  X     X     X  X  X|             
                                            __________________________________________________________________________|             
   Thymus                                  |                                                                      +   |             
      Leukemia Mononuclear                 |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +                                                  +                  |             
      Fibroadenoma                         |                                                       X                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      | X  X                                                                     |             
      Squamous Cell Papilloma              |                            X                          X                  |             
      Sebaceous Gland, Adenoma             |                                                                   X      |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Skin, Site of   |                                                                          |             
          Application, Osteosarcoma        |                         X                                                |             
      Subcutaneous Tissue, Skin, Site of   |                                                                          |             
          Application, Sarcoma             |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         | X  X                          X     X        X     X     X               |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                   X  X     X     X     X                          X      |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  33                                                               
NTP Experiment-Test: 88034-07                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:25:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 5| 2| 4| 7| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 4| 6| 6| 6| 7| 6| 5|             
                             DAY ON TEST   | 1| 6| 5| 5| 5| 5| 3| 8| 4| 0| 0| 8| 8| 6| 3| 4| 1| 5| 7| 9| 6| 4| 2| 8| 9|             
                                           | 7| 2| 8| 7| 3| 6| 6| 3| 1| 3| 3| 7| 3| 9| 6| 0| 0| 5| 0| 7| 1| 0| 5| 3| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    1M/K NNK                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    /OZONE                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                      X  X                    X           X  X  X         |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                   X                       X                              |             
      Leukemia Mononuclear                 | X     X  X              X  X     X  X  X  X  X        X     X     X  X   |             
      Sarcoma, Metastatic, Skin            |                         X                                                |             
      Squamous Cell Carcinoma              |                   X                                                      |             
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                X         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                         +|             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |          +           +  +  +     +     +  +  +        +           +  +  +|             
      Leukemia Mononuclear                 |          X                             X              X                  |             
      Transitional Epithelium, Carcinoma   |                                                       X                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X  X        X  X  X  X  X  X  X  X  X  X  X  X  X     X     X  X  X|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  34                                                               
NTP Experiment-Test: 88034-07                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:25:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5| 7| 7| 6| 7| 7| 4| 6| 5| 6| 5| 6| 6| 5| 6| 6| 7| 5| 6| 4| 7|     |            |
                             DAY ON TEST   | 0| 3| 5| 3| 0| 3| 1| 3| 1| 0| 8| 6| 8| 7| 1| 8| 3| 8| 0| 8| 7| 0| 0|     |            |
                                           | 3| 6| 7| 6| 5| 5| 2| 6| 6| 2| 5| 9| 0| 1| 3| 2| 5| 7| 0| 1| 8| 3| 4|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   FISCHER 344 RATS MALE                   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|     |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     A      |
    1M/K NNK                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |     L      |
    /OZONE                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|     |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                        +                                 |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                           +                              |   1        |
      Leukemia Mononuclear                 |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +      |  42        |
      Leukemia Mononuclear                 | X  X     X     X  X     X        X  X  X     X  X  X  X  X  X  X  X      |         34 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +        +           +                                      +            |   8        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                        +        +                        |   2        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |                                                                          |   1        |
      Pheochromocytoma Malignant           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +     +  +        +  +     +        +  +  +        +            |  30        |
      Leukemia Mononuclear                 |          X     X                             X              X            |          4 |
      Pars Distalis, Adenoma               |    X  X        X  X        X        X           X  X        X            |         25 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                    +                     |   1        |
      C-Cell, Adenoma                      |                                                    X                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peritoneum                              |    +  +  +           +  +        +  +  +  +     +  +  +           +      |  26        |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |             +                                                            |   1        |
      Abdominal, Osteosarcoma              |             X                                                            |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                              +                           |   2        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                         +                                      +         |   3        |
                                            __________________________________________________________________________|____________|
   Testes                                  |    +                 +           +  +  +           +  +     +     +      |  19        |
      Interstitial Cell, Adenoma           |    X                 X           X  X  X           X  X     X     X      |         19 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +        +     +        +        +  +  +  +     +  +  +         |  17        |
      Leukemia Mononuclear                 |          X                                   X                           |          4 |
      Deep Cervical, Leukemia Mononuclear  |          X                                X  X                           |          4 |
      Iliac, Leukemia Mononuclear          |                                              X                 X         |          3 |
      Inguinal, Leukemia Mononuclear       |          X                                   X                           |          2 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  35                                                               
NTP Experiment-Test: 88034-07                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:25:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5| 7| 7| 6| 7| 7| 4| 6| 5| 6| 5| 6| 6| 5| 6| 6| 7| 5| 6| 4| 7|     |            |
                             DAY ON TEST   | 0| 3| 5| 3| 0| 3| 1| 3| 1| 0| 8| 6| 8| 7| 1| 8| 3| 8| 0| 8| 7| 0| 0|     |            |
                                           | 3| 6| 7| 6| 5| 5| 2| 6| 6| 2| 5| 9| 0| 1| 3| 2| 5| 7| 0| 1| 8| 3| 4|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   FISCHER 344 RATS MALE                   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|     |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     A      |
    1M/K NNK                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |     L      |
    /OZONE                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|     |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lumbar, Leukemia Mononuclear         |                                                                          |          1 |
      Pancreatic, Leukemia Mononuclear     |          X                       X           X  X        X     X         |          8 |
      Renal, Leukemia Mononuclear          |          X        X     X                 X  X  X           X  X         |         12 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  M  +  M  M  M  +  M  +  M  M  M  M  +  +  +  +  M  +  M  +  +  +      |  30        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
      Leukemia Mononuclear                 |                   X     X              X  X  X  X           X  X         |         20 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Lung                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +        +                                +  +        +  +  +            |  15        |
      Leukemia Mononuclear                 |          X                                X  X           X  X            |         12 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |          +                                +  +              +  +         |   8        |
      Leukemia Mononuclear                 |          X                                X  X              X  X         |          8 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +      |  43        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
      Leukemia Mononuclear                 | X        X     X  X     X        X     X  X  X  X        X  X  X         |         24 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Lung                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +     +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +      |  39        |
      Leukemia Mononuclear                 | X  X     X     X  X  X  X     X  X     X  X  X  X  X  X  X  X  X  X      |         37 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |          +                                                               |   2        |
      Leukemia Mononuclear                 |          X                                                               |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +                                               +                     |   4        |
      Fibroadenoma                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Keratoacanthoma                      |                                                                          |          2 |
      Squamous Cell Papilloma              |                                                                          |          2 |
      Sebaceous Gland, Adenoma             |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                   X      |          1 |
      Subcutaneous Tissue, Skin, Site of   |                                                                          |            |
          Application, Osteosarcoma        |                                                                          |          1 |
      Subcutaneous Tissue, Skin, Site of   |                                                                          |            |
          Application, Sarcoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  36                                                               
NTP Experiment-Test: 88034-07                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:25:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5| 7| 7| 6| 7| 7| 4| 6| 5| 6| 5| 6| 6| 5| 6| 6| 7| 5| 6| 4| 7|     |            |
                             DAY ON TEST   | 0| 3| 5| 3| 0| 3| 1| 3| 1| 0| 8| 6| 8| 7| 1| 8| 3| 8| 0| 8| 7| 0| 0|     |            |
                                           | 3| 6| 7| 6| 5| 5| 2| 6| 6| 2| 5| 9| 0| 1| 3| 2| 5| 7| 0| 1| 8| 3| 4|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   FISCHER 344 RATS MALE                   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|     |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     A      |
    1M/K NNK                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |     L      |
    /OZONE                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|     |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Alveolar/Bronchiolar Adenoma         |    X  X              X           X  X                 X           X      |         14 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                X              X                             X            |          9 |
      Alveolar/Bronchiolar Carcinoma       |    X     X                       X                                       |          9 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         |                                                                          |          2 |
      Leukemia Mononuclear                 |          X        X     X        X     X  X  X           X  X  X         |         24 |
      Sarcoma, Metastatic, Skin            |                                                                          |          1 |
      Squamous Cell Carcinoma              |                                              X                           |          2 |
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |            |
          Carcinoma, Metastatic, Lung      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Leukemia Mononuclear                 |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                            +                             +  +            |   4        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                       +                  |   1        |
      Carcinoma                            |                                                       X                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +     +        +  +     +           +  +  +     +  +  +  +     +      |  25        |
      Leukemia Mononuclear                 |          X                                X  X              X            |          7 |
      Transitional Epithelium, Carcinoma   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                +                                                         |   1        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Leukemia Mononuclear                 | X  X     X     X  X  X  X     X  X  X  X  X  X  X  X  X  X  X  X  X      |         40 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  37                                                               
                                  ------------------------------------------------------------                                      
                                  ----------              END OF REPORT             ----------                                      
                                  ------------------------------------------------------------