TDMS Study 88034-07 Pathology Tables
NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE/NNK Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56
Facility: Battelle Northwest
Chemical CAS #: 10028-15-6
Lock Date: 02/17/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE/NNK Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 5| 5| 6| 5| 6| 7| 6| 7| 5| 6| 6| 7| 6| 5| 6| 7| 6| 5| 4| 5|
DAY ON TEST | 4| 0| 0| 3| 3| 4| 8| 1| 6| 9| 3| 3| 3| 6| 0| 2| 3| 6| 5| 9| 0| 5| 5| 8| 6|
| 3| 0| 0| 6| 8| 0| 9| 1| 2| 8| 6| 3| 6| 4| 4| 0| 6| 9| 6| 7| 4| 5| 6| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
TRIOCT./ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
AIR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Intestine Large, Colon | + |
__________________________________________________________________________|
Intestine Large, Rectum | + |
Polyp Adenomatous | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + +|
Cholangiocarcinoma | X |
Leukemia Mononuclear | X X X X X X X X X|
__________________________________________________________________________|
Mesentery | + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Pancreas | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Forestomach | + |
__________________________________________________________________________|
Stomach, Glandular | + |
__________________________________________________________________________|
Tongue | + |
Squamous Cell Papilloma | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + |
__________________________________________________________________________|
Adrenal Medulla | + + |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X|
Pars Distalis, Carcinoma | X |
__________________________________________________________________________|
Thyroid Gland | + + |
Carcinoma | X |
C-Cell, Carcinoma | |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | |
__________________________________________________________________________|
Tissue NOS | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE/NNK Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 5| 5| 6| 5| 6| 7| 6| 7| 5| 6| 6| 7| 6| 5| 6| 7| 6| 5| 4| 5|
DAY ON TEST | 4| 0| 0| 3| 3| 4| 8| 1| 6| 9| 3| 3| 3| 6| 0| 2| 3| 6| 5| 9| 0| 5| 5| 8| 6|
| 3| 0| 0| 6| 8| 0| 9| 1| 2| 8| 6| 3| 6| 4| 4| 0| 6| 9| 6| 7| 4| 5| 6| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
TRIOCT./ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
AIR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Preputial Gland | + + + |
Adenoma | |
__________________________________________________________________________|
Testes | + + + + + + + + + |
Mesothelioma Malignant | |
Interstitial Cell, Adenoma | X X X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Lymph Node | + + + + |
Iliac, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + M M + M M + + + + + + + + + M + + + + M|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + M + + M|
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + +|
Fibroma | |
Leukemia Mononuclear | X X X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + |
Fibroadenoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X |
Squamous Cell Carcinoma | |
Subcutaneous Tissue, Fibroma | X X |
Subcutaneous Tissue, Skin, Site of | |
Application, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Carcinoma | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE/NNK Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 5| 5| 6| 5| 6| 7| 6| 7| 5| 6| 6| 7| 6| 5| 6| 7| 6| 5| 4| 5|
DAY ON TEST | 4| 0| 0| 3| 3| 4| 8| 1| 6| 9| 3| 3| 3| 6| 0| 2| 3| 6| 5| 9| 0| 5| 5| 8| 6|
| 3| 0| 0| 6| 8| 0| 9| 1| 2| 8| 6| 3| 6| 4| 4| 0| 6| 9| 6| 7| 4| 5| 6| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
TRIOCT./ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
AIR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Cholangiocarcinoma, Metastatic, Liver| X |
Leukemia Mononuclear | X X X X X X X X X X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Sarcoma, Metastatic, Tissue NOS | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X|
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE/NNK Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56
__________________________________________________________________________________________________________________________________
| 6| 4| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 5| 6| 3| 7| 7| 6| 5| 6| 6| 6| | |
DAY ON TEST | 6| 6| 7| 0| 3| 8| 6| 3| 0| 1| 8| 4| 3| 1| 1| 2| 2| 3| 9| 7| 2| 7| 1| | |
| 4| 6| 2| 6| 6| 1| 3| 6| 9| 7| 5| 1| 6| 5| 1| 7| 4| 6| 2| 6| 0| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
TRIOCT./ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 1 |
Polyp Adenomatous | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + | 26 |
Cholangiocarcinoma | | 1 |
Leukemia Mononuclear | X X X X X X X X | 17 |
__________________________________________________________________________|____________|
Mesentery | + + + + | 8 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Pancreas | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 1 |
__________________________________________________________________________|____________|
Tongue | | 1 |
Squamous Cell Papilloma | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 2 |
__________________________________________________________________________|____________|
Heart | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + | 4 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + | 4 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | X X | 3 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 1 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + | 2 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + M + + + + + + + + | 34 |
Leukemia Mononuclear | | 1 |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X | 32 |
Pars Distalis, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + | 3 |
Carcinoma | | 1 |
C-Cell, Carcinoma | X | 1 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + + + + + + + + + + + + + + + | 32 |
Mesothelioma Malignant | X X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 5
NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE/NNK Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56
__________________________________________________________________________________________________________________________________
| 6| 4| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 5| 6| 3| 7| 7| 6| 5| 6| 6| 6| | |
DAY ON TEST | 6| 6| 7| 0| 3| 8| 6| 3| 0| 1| 8| 4| 3| 1| 1| 2| 2| 3| 9| 7| 2| 7| 1| | |
| 4| 6| 2| 6| 6| 1| 3| 6| 9| 7| 5| 1| 6| 5| 1| 7| 4| 6| 2| 6| 0| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
TRIOCT./ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Sarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 8 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + | 20 |
Mesothelioma Malignant | X X | 2 |
Interstitial Cell, Adenoma | X X X X X X X X | 15 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 9 |
Iliac, Leukemia Mononuclear | X | 2 |
Pancreatic, Leukemia Mononuclear | X | 1 |
Renal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + M + + + + + M + + M + M + + + | 38 |
Leukemia Mononuclear | X X X X X X X | 14 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 4 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 2 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + I + + + I + + + + + + + + M + + + + M + | 42 |
Leukemia Mononuclear | X X X X X X | 15 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + | 35 |
Fibroma | X | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X | 27 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + | 4 |
Fibroadenoma | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + | 47 |
Keratoacanthoma | X | 2 |
Squamous Cell Carcinoma | X | 1 |
Subcutaneous Tissue, Fibroma | | 2 |
Subcutaneous Tissue, Skin, Site of | | |
Application, Sarcoma | X X X | 3 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 6
NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE/NNK Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56
__________________________________________________________________________________________________________________________________
| 6| 4| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 5| 6| 3| 7| 7| 6| 5| 6| 6| 6| | |
DAY ON TEST | 6| 6| 7| 0| 3| 8| 6| 3| 0| 1| 8| 4| 3| 1| 1| 2| 2| 3| 9| 7| 2| 7| 1| | |
| 4| 6| 2| 6| 6| 1| 3| 6| 9| 7| 5| 1| 6| 5| 1| 7| 4| 6| 2| 6| 0| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
TRIOCT./ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Alveolar/Bronchiolar Adenoma | X X X | 3 |
Alveolar/Bronchiolar Carcinoma | X | 1 |
Cholangiocarcinoma, Metastatic, Liver| | 1 |
Leukemia Mononuclear | X X X X X X X | 17 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + M + | 47 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + | 27 |
Leukemia Mononuclear | X | 1 |
Sarcoma, Metastatic, Tissue NOS | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | X X X X X X X X X X X X | 28 |
Mesothelioma Malignant | X X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE/NNK Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56
_____________________________________________________________________________________________________________________
| 4| 4| 6| 7| 5| 4| 5| 7| 6| 6| 4| 7| 6| 6| 7| 5| 5| 5| 6| 6| 6| 6| 5| 5| 6|
DAY ON TEST | 1| 7| 1| 3| 8| 6| 4| 1| 8| 2| 6| 3| 6| 4| 0| 8| 0| 1| 3| 5| 2| 3| 8| 5| 8|
| 7| 8| 2| 6| 2| 6| 4| 0| 3| 0| 0| 6| 2| 1| 4| 9| 1| 8| 3| 5| 5| 5| 9| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.1MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
NNK/AIR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Intestine Large, Cecum | + |
__________________________________________________________________________|
Intestine Small, Ileum | |
Carcinoma | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Oral Mucosa | + + |
Pharyngeal, Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | |
__________________________________________________________________________|
Tongue | |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | |
__________________________________________________________________________|
Islets, Pancreatic | + + |
Adenoma | X X |
Carcinoma | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X|
Pars Distalis, Leukemia Mononuclear | X |
__________________________________________________________________________|
Thyroid Gland | + + |
Carcinoma | X |
Bilateral, C-Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Penis | + + |
__________________________________________________________________________|
Preputial Gland | + + + + |
Carcinoma | X |
__________________________________________________________________________|
Prostate | + |
__________________________________________________________________________|
Testes | + + + + + |
Interstitial Cell, Adenoma | X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE/NNK Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56
_____________________________________________________________________________________________________________________
| 4| 4| 6| 7| 5| 4| 5| 7| 6| 6| 4| 7| 6| 6| 7| 5| 5| 5| 6| 6| 6| 6| 5| 5| 6|
DAY ON TEST | 1| 7| 1| 3| 8| 6| 4| 1| 8| 2| 6| 3| 6| 4| 0| 8| 0| 1| 3| 5| 2| 3| 8| 5| 8|
| 7| 8| 2| 6| 2| 6| 4| 0| 3| 0| 0| 6| 2| 1| 4| 9| 1| 8| 3| 5| 5| 5| 9| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.1MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
NNK/AIR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Leukemia Mononuclear | |
Deep Cervical, Leukemia Mononuclear | |
Iliac, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + M M M + M M M + + M + + + + + + + M + + M + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + + M + + + + + + + + + + + + M M + + + + +|
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X X X X X X X X |
Sarcoma | X |
__________________________________________________________________________|
Thymus | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X |
Keratoacanthoma, Multiple | |
Squamous Cell Papilloma | X |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Melanoma Benign | X |
Subcutaneous Tissue, Skin, Site of | |
Application, Sarcoma | X X|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE/NNK Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56
_____________________________________________________________________________________________________________________
| 4| 4| 6| 7| 5| 4| 5| 7| 6| 6| 4| 7| 6| 6| 7| 5| 5| 5| 6| 6| 6| 6| 5| 5| 6|
DAY ON TEST | 1| 7| 1| 3| 8| 6| 4| 1| 8| 2| 6| 3| 6| 4| 0| 8| 0| 1| 3| 5| 2| 3| 8| 5| 8|
| 7| 8| 2| 6| 2| 6| 4| 0| 3| 0| 0| 6| 2| 1| 4| 9| 1| 8| 3| 5| 5| 5| 9| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.1MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
NNK/AIR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Urinary Bladder | + + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE/NNK Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 6| 4| 7| 6| 7| 5| 6| 7| 6| 6| 7| 6| 5| 6| 6| 6| 5| 7| 5| | |
DAY ON TEST | 7| 3| 1| 5| 9| 4| 0| 1| 1| 0| 6| 3| 1| 3| 3| 7| 2| 3| 7| 4| 5| 3| 5| | |
| 9| 6| 5| 5| 7| 4| 4| 7| 6| 1| 3| 6| 3| 9| 6| 3| 9| 5| 1| 1| 1| 6| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
.1MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
NNK/AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 1 |
Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + | 27 |
Leukemia Mononuclear | X X X X X X X X X | 20 |
__________________________________________________________________________|____________|
Mesentery | + + + + | 10 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Oral Mucosa | + + | 4 |
Pharyngeal, Squamous Cell Papilloma | X | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + | 1 |
__________________________________________________________________________|____________|
Tongue | + | 1 |
Squamous Cell Papilloma | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 5 |
Adenoma | | 2 |
Carcinoma | X X X | 3 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + | 35 |
Leukemia Mononuclear | X X | 3 |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X | 32 |
Pars Distalis, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | | 2 |
Carcinoma | | 1 |
Bilateral, C-Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + + + + + + + + + + + | 24 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Penis | + + | 4 |
__________________________________________________________________________|____________|
Preputial Gland | + + | 6 |
Carcinoma | X | 2 |
__________________________________________________________________________|____________|
Prostate | + | 2 |
__________________________________________________________________________|____________|
Testes | + + + + | 9 |
Interstitial Cell, Adenoma | X X X X | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE/NNK Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 6| 4| 7| 6| 7| 5| 6| 7| 6| 6| 7| 6| 5| 6| 6| 6| 5| 7| 5| | |
DAY ON TEST | 7| 3| 1| 5| 9| 4| 0| 1| 1| 0| 6| 3| 1| 3| 3| 7| 2| 3| 7| 4| 5| 3| 5| | |
| 9| 6| 5| 5| 7| 4| 4| 7| 6| 1| 3| 6| 3| 9| 6| 3| 9| 5| 1| 1| 1| 6| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
.1MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
NNK/AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 1 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + | 7 |
Leukemia Mononuclear | X X | 2 |
Deep Cervical, Leukemia Mononuclear | X | 1 |
Iliac, Leukemia Mononuclear | X | 2 |
Renal, Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + M M + + + M + + + M + M M + + + + + | 32 |
Leukemia Mononuclear | X X X X X X | 13 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + | 8 |
Leukemia Mononuclear | X X X | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 8 |
Leukemia Mononuclear | X X X X | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + M I M + + M + M + + + + + + + M I | 37 |
Leukemia Mononuclear | X X X X X X | 16 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 32 |
Leukemia Mononuclear | X X X X X X X X X X | 25 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Thymus | + | 1 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + | 5 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Keratoacanthoma | X | 2 |
Keratoacanthoma, Multiple | X | 1 |
Squamous Cell Papilloma | | 1 |
Subcutaneous Tissue, Fibroma | X X X | 4 |
Subcutaneous Tissue, Melanoma Benign | | 1 |
Subcutaneous Tissue, Skin, Site of | | |
Application, Sarcoma | X X | 4 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE/NNK Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 6| 4| 7| 6| 7| 5| 6| 7| 6| 6| 7| 6| 5| 6| 6| 6| 5| 7| 5| | |
DAY ON TEST | 7| 3| 1| 5| 9| 4| 0| 1| 1| 0| 6| 3| 1| 3| 3| 7| 2| 3| 7| 4| 5| 3| 5| | |
| 9| 6| 5| 5| 7| 4| 4| 7| 6| 1| 3| 6| 3| 9| 6| 3| 9| 5| 1| 1| 1| 6| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
.1MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
NNK/AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Alveolar/Bronchiolar Adenoma | | 2 |
Leukemia Mononuclear | X X X X X X X | 18 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + | 22 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | X X X X X X X X X X | 25 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE/NNK Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56
_____________________________________________________________________________________________________________________
| 5| 5| 6| 6| 7| 6| 6| 5| 7| 7| 5| 6| 6| 6| 4| 5| 6| 6| 6| 5| 6| 6| 7| 5| 6|
DAY ON TEST | 6| 5| 0| 7| 3| 8| 6| 2| 3| 1| 2| 1| 3| 6| 2| 9| 0| 8| 8| 7| 0| 9| 3| 4| 0|
| 2| 1| 3| 8| 6| 3| 3| 8| 6| 5| 9| 7| 9| 1| 9| 0| 3| 3| 7| 9| 4| 5| 6| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
NNK/AIR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Intestine Large, Colon | + |
__________________________________________________________________________|
Intestine Large, Cecum | |
__________________________________________________________________________|
Intestine Small, Jejunum | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Ileum | + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Mesentery | + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Pancreas | |
__________________________________________________________________________|
Stomach, Forestomach | +|
__________________________________________________________________________|
Stomach, Glandular | + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + |
__________________________________________________________________________|
Adrenal Medulla | |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | |
Carcinoma | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + M + + + + + +|
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Penis | + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + |
__________________________________________________________________________|
Seminal Vesicle | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Testes | + + + + + + +|
Interstitial Cell, Adenoma | X X X X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Deep Cervical, Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE/NNK Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56
_____________________________________________________________________________________________________________________
| 5| 5| 6| 6| 7| 6| 6| 5| 7| 7| 5| 6| 6| 6| 4| 5| 6| 6| 6| 5| 6| 6| 7| 5| 6|
DAY ON TEST | 6| 5| 0| 7| 3| 8| 6| 2| 3| 1| 2| 1| 3| 6| 2| 9| 0| 8| 8| 7| 0| 9| 3| 4| 0|
| 2| 1| 3| 8| 6| 3| 3| 8| 6| 5| 9| 7| 9| 1| 9| 0| 3| 3| 7| 9| 4| 5| 6| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
NNK/AIR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Iliac, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X X X X X|
Renal, Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M M M M M M + + M + I + + + + M M M M M +|
Leukemia Mononuclear | X X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + + + + + + + + + + + + + + M + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Thymus | + + |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X |
Trichoepithelioma | X |
Sebaceous Gland, Adenoma | |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Skin, Site of | |
Application, Sarcoma | X X X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X X X X X X X X |
Alveolar/Bronchiolar Carcinoma | X X X X X X |
Leukemia Mononuclear | X X X X X X X X X X|
Sarcoma, Metastatic, Skin | X |
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE/NNK Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56
_____________________________________________________________________________________________________________________
| 5| 5| 6| 6| 7| 6| 6| 5| 7| 7| 5| 6| 6| 6| 4| 5| 6| 6| 6| 5| 6| 6| 7| 5| 6|
DAY ON TEST | 6| 5| 0| 7| 3| 8| 6| 2| 3| 1| 2| 1| 3| 6| 2| 9| 0| 8| 8| 7| 0| 9| 3| 4| 0|
| 2| 1| 3| 8| 6| 3| 3| 8| 6| 5| 9| 7| 9| 1| 9| 0| 3| 3| 7| 9| 4| 5| 6| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
NNK/AIR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Respiratory Epithelium, Adenoma | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Ureter | + |
__________________________________________________________________________|
Urinary Bladder | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE/NNK Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 7| 4| 5| 4| 7| 5| 5| 4| 6| 4| 6| 6| 6| 5| 6| 5| 5| 6| | |
DAY ON TEST | 8| 4| 0| 0| 0| 1| 8| 4| 5| 3| 9| 3| 8| 9| 8| 7| 8| 0| 8| 6| 5| 8| 4| | |
| 3| 5| 4| 3| 5| 2| 6| 0| 0| 6| 0| 3| 9| 5| 8| 7| 3| 5| 3| 9| 0| 3| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
NNK/AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + | 39 |
Hepatocellular Adenoma | X | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X | 35 |
__________________________________________________________________________|____________|
Mesentery | + + + + | 8 |
Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Pancreas | + | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 4 |
__________________________________________________________________________|____________|
Adrenal Medulla | + | 1 |
Pheochromocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 1 |
Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + | 34 |
Leukemia Mononuclear | X X X | 3 |
Pars Distalis, Adenoma | X X X X X X X X X X X X X | 31 |
__________________________________________________________________________|____________|
Thyroid Gland | | 1 |
C-Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + + + + + + + + + + + + + + + | 32 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Penis | + | 5 |
__________________________________________________________________________|____________|
Preputial Gland | + + + | 9 |
__________________________________________________________________________|____________|
Seminal Vesicle | + | 1 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + | 13 |
Interstitial Cell, Adenoma | X X X X X X | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 17
NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE/NNK Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 7| 4| 5| 4| 7| 5| 5| 4| 6| 4| 6| 6| 6| 5| 6| 5| 5| 6| | |
DAY ON TEST | 8| 4| 0| 0| 0| 1| 8| 4| 5| 3| 9| 3| 8| 9| 8| 7| 8| 0| 8| 6| 5| 8| 4| | |
| 3| 5| 4| 3| 5| 2| 6| 0| 0| 6| 0| 3| 9| 5| 8| 7| 3| 5| 3| 9| 0| 3| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
NNK/AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + | 26 |
Leukemia Mononuclear | X | 2 |
Deep Cervical, Leukemia Mononuclear | | 2 |
Iliac, Leukemia Mononuclear | X | 2 |
Pancreatic, Leukemia Mononuclear | X X X X X X X X | 13 |
Renal, Leukemia Mononuclear | X X X X X X X | 12 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + + + + M + + M + M + M + + + + + M M | 28 |
Leukemia Mononuclear | X X X X X X X X X X X X X | 21 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 14 |
Leukemia Mononuclear | X X X X X | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 9 |
Leukemia Mononuclear | X X X X X X | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + M + | 45 |
Leukemia Mononuclear | X X X X X X X X X X X X X X | 26 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + | 39 |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X | 35 |
__________________________________________________________________________|____________|
Thymus | + | 3 |
Leukemia Mononuclear | X | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + | 5 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + | 47 |
Keratoacanthoma | X | 2 |
Trichoepithelioma | | 1 |
Sebaceous Gland, Adenoma | X | 1 |
Subcutaneous Tissue, Fibroma | X | 1 |
Subcutaneous Tissue, Skin, Site of | | |
Application, Sarcoma | X | 5 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 18
NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE/NNK Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 7| 4| 5| 4| 7| 5| 5| 4| 6| 4| 6| 6| 6| 5| 6| 5| 5| 6| | |
DAY ON TEST | 8| 4| 0| 0| 0| 1| 8| 4| 5| 3| 9| 3| 8| 9| 8| 7| 8| 0| 8| 6| 5| 8| 4| | |
| 3| 5| 4| 3| 5| 2| 6| 0| 0| 6| 0| 3| 9| 5| 8| 7| 3| 5| 3| 9| 0| 3| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
NNK/AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Alveolar/Bronchiolar Adenoma | X X X X X | 11 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | X | 9 |
Alveolar/Bronchiolar Carcinoma | X X | 8 |
Leukemia Mononuclear | X X X X X X X X X X | 20 |
Sarcoma, Metastatic, Skin | | 1 |
Squamous Cell Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | | 2 |
Respiratory Epithelium, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + | 24 |
Leukemia Mononuclear | X X X X X | 7 |
__________________________________________________________________________|____________|
Ureter | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X | 37 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 19
NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE/NNK Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56
_____________________________________________________________________________________________________________________
| 7| 5| 6| 4| 4| 6| 6| 5| 6| 6| 3| 3| 1| 7| 6| 5| 7| 7| 5| 5| 5| 6| 7| 6| 6|
DAY ON TEST | 2| 5| 0| 5| 4| 3| 6| 0| 7| 7| 8| 3| 9| 1| 2| 8| 3| 0| 2| 9| 1| 4| 0| 1| 1|
| 5| 6| 3| 8| 0| 6| 9| 2| 8| 3| 9| 3| 2| 2| 4| 9| 6| 9| 3| 2| 5| 5| 4| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
TRIOCT./ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
OZONE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Intestine Large, Colon | |
__________________________________________________________________________|
Intestine Large, Rectum | |
__________________________________________________________________________|
Intestine Large, Cecum | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Mesentery | + + + + +|
Leukemia Mononuclear | |
Sarcoma | X|
Sarcoma, Metastatic, Tissue NOS | X |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Forestomach | + |
__________________________________________________________________________|
Stomach, Glandular | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + +|
Adenoma | X |
__________________________________________________________________________|
Islets, Pancreatic | + |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | |
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + +|
Schwannoma Malignant, Metastatic, | |
Tissue NOS | |
Pars Distalis, Adenoma | X X X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tissue NOS | + + + + + |
Sarcoma | X X X X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Penis | +|
__________________________________________________________________________|
Preputial Gland | + + + + + |
Adenoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Prostate | + |
__________________________________________________________________________|
Testes | + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE/NNK Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56
_____________________________________________________________________________________________________________________
| 7| 5| 6| 4| 4| 6| 6| 5| 6| 6| 3| 3| 1| 7| 6| 5| 7| 7| 5| 5| 5| 6| 7| 6| 6|
DAY ON TEST | 2| 5| 0| 5| 4| 3| 6| 0| 7| 7| 8| 3| 9| 1| 2| 8| 3| 0| 2| 9| 1| 4| 0| 1| 1|
| 5| 6| 3| 8| 0| 6| 9| 2| 8| 3| 9| 3| 2| 2| 4| 9| 6| 9| 3| 2| 5| 5| 4| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
TRIOCT./ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
OZONE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Interstitial Cell, Adenoma | X X X X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Lymph Node | + + + |
Iliac, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | M M M + + + + M + + + + M + M + + M + M + M M M +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mesenteric | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + I + + + + + + + + M + + + + M + M + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X |
__________________________________________________________________________|
Thymus | + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X X X |
Squamous Cell Papilloma | |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Skin, Site of | |
Application, Sarcoma | X X X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | |
Leukemia Mononuclear | |
Cranial Nerve, Schwannoma Malignant | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pleura | + |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE/NNK Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56
_____________________________________________________________________________________________________________________
| 7| 5| 6| 4| 4| 6| 6| 5| 6| 6| 3| 3| 1| 7| 6| 5| 7| 7| 5| 5| 5| 6| 7| 6| 6|
DAY ON TEST | 2| 5| 0| 5| 4| 3| 6| 0| 7| 7| 8| 3| 9| 1| 2| 8| 3| 0| 2| 9| 1| 4| 0| 1| 1|
| 5| 6| 3| 8| 0| 6| 9| 2| 8| 3| 9| 3| 2| 2| 4| 9| 6| 9| 3| 2| 5| 5| 4| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
TRIOCT./ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
OZONE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Mesothelioma Malignant | |
Sarcoma, Metastatic, Tissue NOS | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Urinary Bladder | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE/NNK Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 6| 6| 7| 7| 5| 5| 6| 6| 6| 6| 2| 6| 6| 7| 5| 7| 5| 6| 5| 4| | |
DAY ON TEST | 3| 9| 0| 3| 9| 3| 0| 8| 5| 6| 5| 3| 3| 5| 3| 1| 2| 3| 1| 2| 3| 6| 8| | |
| 6| 0| 5| 5| 4| 6| 5| 0| 0| 1| 9| 4| 4| 3| 1| 4| 2| 7| 8| 9| 5| 0| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
TRIOCT./ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
OZONE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A | |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + | 28 |
Leukemia Mononuclear | X X X X X X X X X X | 18 |
__________________________________________________________________________|____________|
Mesentery | + + + | 8 |
Leukemia Mononuclear | X | 1 |
Sarcoma | | 1 |
Sarcoma, Metastatic, Tissue NOS | | 1 |
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
__________________________________________________________________________|____________|
Pancreas | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________|____________|
Heart | + | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | | 3 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 1 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + | 29 |
Schwannoma Malignant, Metastatic, | | |
Tissue NOS | X | 1 |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X | 28 |
__________________________________________________________________________|____________|
Thyroid Gland | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + + + + + + + + + + + + + + + + | 30 |
__________________________________________________________________________|____________|
Tissue NOS | | 5 |
Sarcoma | | 4 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Penis | + + | 3 |
__________________________________________________________________________|____________|
Preputial Gland | + + + | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 23
NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE/NNK Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 6| 6| 7| 7| 5| 5| 6| 6| 6| 6| 2| 6| 6| 7| 5| 7| 5| 6| 5| 4| | |
DAY ON TEST | 3| 9| 0| 3| 9| 3| 0| 8| 5| 6| 5| 3| 3| 5| 3| 1| 2| 3| 1| 2| 3| 6| 8| | |
| 6| 0| 5| 5| 4| 6| 5| 0| 0| 1| 9| 4| 4| 3| 1| 4| 2| 7| 8| 9| 5| 0| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
TRIOCT./ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
OZONE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Adenoma | X | 1 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Prostate | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + | 24 |
Leukemia Mononuclear | X | 1 |
Interstitial Cell, Adenoma | X X X X X X X X X X X X | 20 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + | 10 |
Iliac, Leukemia Mononuclear | X | 2 |
Pancreatic, Leukemia Mononuclear | X X X | 5 |
Renal, Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M M + + M M M M + + + M + M M M M M + M + + | 23 |
Leukemia Mononuclear | X X X X X X | 12 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + | 7 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 3 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + M + + + + + + + | 43 |
Leukemia Mononuclear | X X X X X X X X | 18 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + | 33 |
Leukemia Mononuclear | X X X X X X X X X X X X | 24 |
__________________________________________________________________________|____________|
Thymus | | 1 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Keratoacanthoma | X | 4 |
Squamous Cell Papilloma | X | 1 |
Subcutaneous Tissue, Fibroma | X | 2 |
Subcutaneous Tissue, Skin, Site of | | |
Application, Sarcoma | X | 5 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 24
NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE/NNK Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 6| 6| 7| 7| 5| 5| 6| 6| 6| 6| 2| 6| 6| 7| 5| 7| 5| 6| 5| 4| | |
DAY ON TEST | 3| 9| 0| 3| 9| 3| 0| 8| 5| 6| 5| 3| 3| 5| 3| 1| 2| 3| 1| 2| 3| 6| 8| | |
| 6| 0| 5| 5| 4| 6| 5| 0| 0| 1| 9| 4| 4| 3| 1| 4| 2| 7| 8| 9| 5| 0| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
TRIOCT./ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
OZONE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X | 1 |
Cranial Nerve, Schwannoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Alveolar/Bronchiolar Adenoma | X | 1 |
Leukemia Mononuclear | X X X X X X X X X X X | 21 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Pleura | + | 2 |
Mesothelioma Malignant | X | 1 |
Sarcoma, Metastatic, Tissue NOS | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + A + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 15 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | X X X X X X X X X X X X X | 25 |
Mesothelioma Malignant | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 25
NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE/NNK Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 7| 6| 4| 6| 6| 6| 5| 5| 2| 7| 6| 6| 6| 5| 5| 5| 4| 6| 5| 7| 6|
DAY ON TEST | 3| 0| 7| 4| 3| 9| 6| 7| 9| 6| 8| 6| 3| 1| 0| 6| 8| 6| 5| 6| 4| 8| 5| 1| 6|
| 6| 4| 3| 9| 6| 7| 0| 1| 8| 9| 3| 9| 4| 0| 5| 2| 3| 7| 0| 5| 4| 0| 2| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
.1M/KNNK | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
/OZONE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Intestine Large, Cecum | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Ileum | + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Mesentery | + + + + + |
Leukemia Mononuclear | X X X |
Sarcoma | |
__________________________________________________________________________|
Stomach, Forestomach | + |
__________________________________________________________________________|
Stomach, Glandular | + |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + |
__________________________________________________________________________|
Parathyroid Gland | + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
Pars Distalis, Adenoma | X X X X X X X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + + + + + + + + + + + + + + +|
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | |
Mesothelioma Malignant | |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + |
__________________________________________________________________________|
Prostate | + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | |
Interstitial Cell, Adenoma | X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + |
Leukemia Mononuclear | X X |
Deep Cervical, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE/NNK Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 7| 6| 4| 6| 6| 6| 5| 5| 2| 7| 6| 6| 6| 5| 5| 5| 4| 6| 5| 7| 6|
DAY ON TEST | 3| 0| 7| 4| 3| 9| 6| 7| 9| 6| 8| 6| 3| 1| 0| 6| 8| 6| 5| 6| 4| 8| 5| 1| 6|
| 6| 4| 3| 9| 6| 7| 0| 1| 8| 9| 3| 9| 4| 0| 5| 2| 3| 7| 0| 5| 4| 0| 2| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
.1M/KNNK | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
/OZONE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Iliac, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + M M + + + M M + M M + M + M + M + + + + M|
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X X|
Mesothelioma Malignant | |
__________________________________________________________________________|
Thymus | + + + |
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Adenoma | X |
Keratoacanthoma | |
Subcutaneous Tissue, Skin, Site of | |
Application, Sarcoma | X X |
Subcutaneous Tissue, Skin, Site of | |
Application, Sarcoma, Multiple | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Leukemia Mononuclear | X X X X X X X X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE/NNK Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 7| 6| 4| 6| 6| 6| 5| 5| 2| 7| 6| 6| 6| 5| 5| 5| 4| 6| 5| 7| 6|
DAY ON TEST | 3| 0| 7| 4| 3| 9| 6| 7| 9| 6| 8| 6| 3| 1| 0| 6| 8| 6| 5| 6| 4| 8| 5| 1| 6|
| 6| 4| 3| 9| 6| 7| 0| 1| 8| 9| 3| 9| 4| 0| 5| 2| 3| 7| 0| 5| 4| 0| 2| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
.1M/KNNK | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
/OZONE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Urinary Bladder | + + |
Leukemia Mononuclear | X |
Papilloma | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X X X|
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE/NNK Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 7| 6| 6| 5| 4| 7| 4| 5| 6| 6| 6| 7| 6| 7| 7| 6| 7| 4| 6| | |
DAY ON TEST | 8| 1| 3| 2| 3| 3| 6| 7| 9| 3| 4| 6| 4| 3| 0| 0| 8| 3| 3| 3| 2| 1| 8| | |
| 1| 3| 6| 0| 3| 5| 9| 5| 6| 6| 4| 7| 1| 8| 4| 3| 3| 6| 6| 2| 5| 6| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
.1M/KNNK | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
/OZONE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + | 36 |
Leukemia Mononuclear | X X X X X X X X X X X X X X | 30 |
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 11 |
Leukemia Mononuclear | | 3 |
Sarcoma | X X | 2 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + | 2 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 27 |
Leukemia Mononuclear | X | 4 |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X | 23 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + + + + + + + + + + + + + + + + | 31 |
Mesothelioma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + | 1 |
Mesothelioma Malignant | X | 1 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + | 2 |
__________________________________________________________________________|____________|
Prostate | + | 2 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + | 25 |
Leukemia Mononuclear | | 1 |
Mesothelioma Malignant | X | 1 |
Interstitial Cell, Adenoma | X X X X X X X X X X X X | 23 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 29
NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE/NNK Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 7| 6| 6| 5| 4| 7| 4| 5| 6| 6| 6| 7| 6| 7| 7| 6| 7| 4| 6| | |
DAY ON TEST | 8| 1| 3| 2| 3| 3| 6| 7| 9| 3| 4| 6| 4| 3| 0| 0| 8| 3| 3| 3| 2| 1| 8| | |
| 1| 3| 6| 0| 3| 5| 9| 5| 6| 6| 4| 7| 1| 8| 4| 3| 3| 6| 6| 2| 5| 6| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
.1M/KNNK | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
/OZONE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + | 10 |
Leukemia Mononuclear | | 2 |
Deep Cervical, Leukemia Mononuclear | | 1 |
Iliac, Leukemia Mononuclear | | 1 |
Pancreatic, Leukemia Mononuclear | | 1 |
Renal, Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + + + M M M M + + + I + + + M M M + M M | 26 |
Leukemia Mononuclear | X | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 7 |
Leukemia Mononuclear | | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 11 |
Leukemia Mononuclear | X | 11 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + M + + M + + + + + + + + + M + + M + M + | 43 |
Leukemia Mononuclear | X X X X X X X | 21 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + | 37 |
Leukemia Mononuclear | X X X X X X X X X X X X X X X | 34 |
Mesothelioma Malignant | X | 1 |
__________________________________________________________________________|____________|
Thymus | | 3 |
Leukemia Mononuclear | | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Basal Cell Adenoma | | 1 |
Keratoacanthoma | X X | 2 |
Subcutaneous Tissue, Skin, Site of | | |
Application, Sarcoma | X X X | 5 |
Subcutaneous Tissue, Skin, Site of | | |
Application, Sarcoma, Multiple | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 30
NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE/NNK Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 7| 6| 6| 5| 4| 7| 4| 5| 6| 6| 6| 7| 6| 7| 7| 6| 7| 4| 6| | |
DAY ON TEST | 8| 1| 3| 2| 3| 3| 6| 7| 9| 3| 4| 6| 4| 3| 0| 0| 8| 3| 3| 3| 2| 1| 8| | |
| 1| 3| 6| 0| 3| 5| 9| 5| 6| 6| 4| 7| 1| 8| 4| 3| 3| 6| 6| 2| 5| 6| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
.1M/KNNK | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
/OZONE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Alveolar/Bronchiolar Adenoma | | 2 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | X | 1 |
Leukemia Mononuclear | X X X X X X | 20 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + I + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | + + + | 3 |
Carcinoma | X X X | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + | 20 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + | 3 |
Leukemia Mononuclear | | 1 |
Papilloma | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | X X X X X X X X X X X X X X X | 35 |
Mesothelioma Malignant | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 31
NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE/NNK Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56
_____________________________________________________________________________________________________________________
| 6| 5| 5| 5| 2| 4| 7| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 4| 6| 6| 6| 7| 6| 5|
DAY ON TEST | 1| 6| 5| 5| 5| 5| 3| 8| 4| 0| 0| 8| 8| 6| 3| 4| 1| 5| 7| 9| 6| 4| 2| 8| 9|
| 7| 2| 8| 7| 3| 6| 6| 3| 1| 3| 3| 7| 3| 9| 6| 0| 0| 5| 0| 7| 1| 0| 5| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
1M/K NNK | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
/OZONE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Intestine Large, Cecum | + |
__________________________________________________________________________|
Intestine Small, Ileum | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + + + + |
__________________________________________________________________________|
Stomach, Forestomach | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Medulla | + |
Pheochromocytoma Malignant | X |
__________________________________________________________________________|
Parathyroid Gland | + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | |
C-Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + + + + + + + + + + + + +|
__________________________________________________________________________|
Tissue NOS | |
Abdominal, Osteosarcoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + |
__________________________________________________________________________|
Testes | + + + + + + + + + + |
Interstitial Cell, Adenoma | X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + +|
Leukemia Mononuclear | X X |
Deep Cervical, Leukemia Mononuclear | X |
Iliac, Leukemia Mononuclear | X |
Inguinal, Leukemia Mononuclear | |
Lumbar, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X X |
Renal, Leukemia Mononuclear | X X X X|
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + + + + M + M + + + + M + + + + M + M + + +|
Alveolar/Bronchiolar Carcinoma, | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE/NNK Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56
_____________________________________________________________________________________________________________________
| 6| 5| 5| 5| 2| 4| 7| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 4| 6| 6| 6| 7| 6| 5|
DAY ON TEST | 1| 6| 5| 5| 5| 5| 3| 8| 4| 0| 0| 8| 8| 6| 3| 4| 1| 5| 7| 9| 6| 4| 2| 8| 9|
| 7| 2| 8| 7| 3| 6| 6| 3| 1| 3| 3| 7| 3| 9| 6| 0| 0| 5| 0| 7| 1| 0| 5| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
1M/K NNK | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
/OZONE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Metastatic, Lung | X |
Leukemia Mononuclear | X X X X X X X X X X X X |
Squamous Cell Carcinoma, Metastatic, | |
Lung | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + +|
Leukemia Mononuclear | X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + M + + + + + + + + M + M + M + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Leukemia Mononuclear | X X X X X X X X X X X |
Squamous Cell Carcinoma, Metastatic, | |
Lung | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Thymus | + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + |
Fibroadenoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X X |
Squamous Cell Papilloma | X X |
Sebaceous Gland, Adenoma | X |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Skin, Site of | |
Application, Osteosarcoma | X |
Subcutaneous Tissue, Skin, Site of | |
Application, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X X X X X X |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE/NNK Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56
_____________________________________________________________________________________________________________________
| 6| 5| 5| 5| 2| 4| 7| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 4| 6| 6| 6| 7| 6| 5|
DAY ON TEST | 1| 6| 5| 5| 5| 5| 3| 8| 4| 0| 0| 8| 8| 6| 3| 4| 1| 5| 7| 9| 6| 4| 2| 8| 9|
| 7| 2| 8| 7| 3| 6| 6| 3| 1| 3| 3| 7| 3| 9| 6| 0| 0| 5| 0| 7| 1| 0| 5| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
1M/K NNK | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
/OZONE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar/Bronchiolar Carcinoma | X X X X X X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X X |
Leukemia Mononuclear | X X X X X X X X X X X X X X |
Sarcoma, Metastatic, Skin | X |
Squamous Cell Carcinoma | X |
Mediastinum, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + A + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + A + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | +|
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Transitional Epithelium, Carcinoma | X |
__________________________________________________________________________|
Urinary Bladder | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE/NNK Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 6| 7| 7| 4| 6| 5| 6| 5| 6| 6| 5| 6| 6| 7| 5| 6| 4| 7| | |
DAY ON TEST | 0| 3| 5| 3| 0| 3| 1| 3| 1| 0| 8| 6| 8| 7| 1| 8| 3| 8| 0| 8| 7| 0| 0| | |
| 3| 6| 7| 6| 5| 5| 2| 6| 6| 2| 5| 9| 0| 1| 3| 2| 5| 7| 0| 1| 8| 3| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
1M/K NNK | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
/OZONE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 1 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + | 42 |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X | 34 |
__________________________________________________________________________|____________|
Mesentery | + + + + | 8 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 2 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Medulla | | 1 |
Pheochromocytoma Malignant | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + | 30 |
Leukemia Mononuclear | X X X X | 4 |
Pars Distalis, Adenoma | X X X X X X X X X | 25 |
__________________________________________________________________________|____________|
Thyroid Gland | + | 1 |
C-Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + + + + + + + + + + + + + | 26 |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Abdominal, Osteosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Penis | + | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + + | 3 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + | 19 |
Interstitial Cell, Adenoma | X X X X X X X X X | 19 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + | 17 |
Leukemia Mononuclear | X X | 4 |
Deep Cervical, Leukemia Mononuclear | X X X | 4 |
Iliac, Leukemia Mononuclear | X X | 3 |
Inguinal, Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 35
NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE/NNK Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 6| 7| 7| 4| 6| 5| 6| 5| 6| 6| 5| 6| 6| 7| 5| 6| 4| 7| | |
DAY ON TEST | 0| 3| 5| 3| 0| 3| 1| 3| 1| 0| 8| 6| 8| 7| 1| 8| 3| 8| 0| 8| 7| 0| 0| | |
| 3| 6| 7| 6| 5| 5| 2| 6| 6| 2| 5| 9| 0| 1| 3| 2| 5| 7| 0| 1| 8| 3| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
1M/K NNK | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
/OZONE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lumbar, Leukemia Mononuclear | | 1 |
Pancreatic, Leukemia Mononuclear | X X X X X X | 8 |
Renal, Leukemia Mononuclear | X X X X X X X X | 12 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M + M M M + M + M M M M + + + + M + M + + + | 30 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Leukemia Mononuclear | X X X X X X X X | 20 |
Squamous Cell Carcinoma, Metastatic, | | |
Lung | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + | 15 |
Leukemia Mononuclear | X X X X X | 12 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 8 |
Leukemia Mononuclear | X X X X X | 8 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + M + + + + + + + + + + | 43 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X X | 24 |
Squamous Cell Carcinoma, Metastatic, | | |
Lung | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + | 39 |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X X | 37 |
__________________________________________________________________________|____________|
Thymus | + | 2 |
Leukemia Mononuclear | X | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + | 4 |
Fibroadenoma | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Keratoacanthoma | | 2 |
Squamous Cell Papilloma | | 2 |
Sebaceous Gland, Adenoma | | 1 |
Subcutaneous Tissue, Fibroma | X | 1 |
Subcutaneous Tissue, Skin, Site of | | |
Application, Osteosarcoma | | 1 |
Subcutaneous Tissue, Skin, Site of | | |
Application, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 36
NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE/NNK Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 6| 7| 7| 4| 6| 5| 6| 5| 6| 6| 5| 6| 6| 7| 5| 6| 4| 7| | |
DAY ON TEST | 0| 3| 5| 3| 0| 3| 1| 3| 1| 0| 8| 6| 8| 7| 1| 8| 3| 8| 0| 8| 7| 0| 0| | |
| 3| 6| 7| 6| 5| 5| 2| 6| 6| 2| 5| 9| 0| 1| 3| 2| 5| 7| 0| 1| 8| 3| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
1M/K NNK | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
/OZONE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Alveolar/Bronchiolar Adenoma | X X X X X X X | 14 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | X X X | 9 |
Alveolar/Bronchiolar Carcinoma | X X X | 9 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | | 2 |
Leukemia Mononuclear | X X X X X X X X X X | 24 |
Sarcoma, Metastatic, Skin | | 1 |
Squamous Cell Carcinoma | X | 2 |
Mediastinum, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | | 1 |
__________________________________________________________________________|____________|
Nose | A + + + + + + + + + + + + + + + + + + + + + + | 46 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Trachea | A + + + + + + + + + + + + + + + + + + + + + + | 46 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 4 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + | 25 |
Leukemia Mononuclear | X X X X | 7 |
Transitional Epithelium, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X X X | 40 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 37
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---------- END OF REPORT ----------
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