TDMS Study 88034-07 Pathology Tables
NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE/NNK Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56 Facility: Battelle Northwest Chemical CAS #: 10028-15-6 Lock Date: 02/17/93 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE/NNK Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 6| 5| 5| 6| 5| 6| 7| 6| 7| 5| 6| 6| 7| 6| 5| 6| 7| 6| 5| 4| 5| DAY ON TEST | 4| 0| 0| 3| 3| 4| 8| 1| 6| 9| 3| 3| 3| 6| 0| 2| 3| 6| 5| 9| 0| 5| 5| 8| 6| | 3| 0| 0| 6| 8| 0| 9| 1| 2| 8| 6| 3| 6| 4| 4| 0| 6| 9| 6| 7| 4| 5| 6| 4| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TRIOCT./ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| AIR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Intestine Large, Colon | + | __________________________________________________________________________| Intestine Large, Rectum | + | Polyp Adenomatous | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + +| Cholangiocarcinoma | X | Leukemia Mononuclear | X X X X X X X X X| __________________________________________________________________________| Mesentery | + + + + | Leukemia Mononuclear | X | __________________________________________________________________________| Pancreas | + | Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Forestomach | + | __________________________________________________________________________| Stomach, Glandular | + | __________________________________________________________________________| Tongue | + | Squamous Cell Papilloma | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | __________________________________________________________________________| Heart | + | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + | __________________________________________________________________________| Adrenal Medulla | + + | Pheochromocytoma Malignant | X | Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + | Carcinoma | X | __________________________________________________________________________| Parathyroid Gland | + | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X| Pars Distalis, Carcinoma | X | __________________________________________________________________________| Thyroid Gland | + + | Carcinoma | X | C-Cell, Carcinoma | | Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | | __________________________________________________________________________| Tissue NOS | | Sarcoma | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + | _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE/NNK Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 6| 5| 5| 6| 5| 6| 7| 6| 7| 5| 6| 6| 7| 6| 5| 6| 7| 6| 5| 4| 5| DAY ON TEST | 4| 0| 0| 3| 3| 4| 8| 1| 6| 9| 3| 3| 3| 6| 0| 2| 3| 6| 5| 9| 0| 5| 5| 8| 6| | 3| 0| 0| 6| 8| 0| 9| 1| 2| 8| 6| 3| 6| 4| 4| 0| 6| 9| 6| 7| 4| 5| 6| 4| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TRIOCT./ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| AIR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Preputial Gland | + + + | Adenoma | | __________________________________________________________________________| Testes | + + + + + + + + + | Mesothelioma Malignant | | Interstitial Cell, Adenoma | X X X X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Lymph Node | + + + + | Iliac, Leukemia Mononuclear | X | Pancreatic, Leukemia Mononuclear | | Renal, Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + M M + M M + + + + + + + + + M + + + + M| Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + | Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + | Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + M + + M| Leukemia Mononuclear | X X X X X X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + +| Fibroma | | Leukemia Mononuclear | X X X X X X X X X X X X X X X| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + | Fibroadenoma | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X | Squamous Cell Carcinoma | | Subcutaneous Tissue, Fibroma | X X | Subcutaneous Tissue, Skin, Site of | | Application, Sarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Alveolar/Bronchiolar Carcinoma | | _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE/NNK Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 6| 5| 5| 6| 5| 6| 7| 6| 7| 5| 6| 6| 7| 6| 5| 6| 7| 6| 5| 4| 5| DAY ON TEST | 4| 0| 0| 3| 3| 4| 8| 1| 6| 9| 3| 3| 3| 6| 0| 2| 3| 6| 5| 9| 0| 5| 5| 8| 6| | 3| 0| 0| 6| 8| 0| 9| 1| 2| 8| 6| 3| 6| 4| 4| 0| 6| 9| 6| 7| 4| 5| 6| 4| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TRIOCT./ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| AIR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Cholangiocarcinoma, Metastatic, Liver| X | Leukemia Mononuclear | X X X X X X X X X X| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + +| Leukemia Mononuclear | | Sarcoma, Metastatic, Tissue NOS | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X X| Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE/NNK Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56 __________________________________________________________________________________________________________________________________ | 6| 4| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 5| 6| 3| 7| 7| 6| 5| 6| 6| 6| | | DAY ON TEST | 6| 6| 7| 0| 3| 8| 6| 3| 0| 1| 8| 4| 3| 1| 1| 2| 2| 3| 9| 7| 2| 7| 1| | | | 4| 6| 2| 6| 6| 1| 3| 6| 9| 7| 5| 1| 6| 5| 1| 7| 4| 6| 2| 6| 0| 3| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | TRIOCT./ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Intestine Large, Colon | | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | | 1 | Polyp Adenomatous | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + | 26 | Cholangiocarcinoma | | 1 | Leukemia Mononuclear | X X X X X X X X | 17 | __________________________________________________________________________|____________| Mesentery | + + + + | 8 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Pancreas | | 1 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | | 1 | __________________________________________________________________________|____________| Tongue | | 1 | Squamous Cell Papilloma | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + | 2 | __________________________________________________________________________|____________| Heart | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + | 4 | __________________________________________________________________________|____________| Adrenal Medulla | + + | 4 | Pheochromocytoma Malignant | | 1 | Pheochromocytoma Benign | X X | 3 | __________________________________________________________________________|____________| Islets, Pancreatic | | 1 | Carcinoma | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + | 2 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + M + + + + + + + + | 34 | Leukemia Mononuclear | | 1 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X | 32 | Pars Distalis, Carcinoma | | 1 | __________________________________________________________________________|____________| Thyroid Gland | + | 3 | Carcinoma | | 1 | C-Cell, Carcinoma | X | 1 | Follicular Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Peritoneum | + + + + + + + + + + + + + + + | 32 | Mesothelioma Malignant | X X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 5 NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE/NNK Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56 __________________________________________________________________________________________________________________________________ | 6| 4| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 5| 6| 3| 7| 7| 6| 5| 6| 6| 6| | | DAY ON TEST | 6| 6| 7| 0| 3| 8| 6| 3| 0| 1| 8| 4| 3| 1| 1| 2| 2| 3| 9| 7| 2| 7| 1| | | | 4| 6| 2| 6| 6| 1| 3| 6| 9| 7| 5| 1| 6| 5| 1| 7| 4| 6| 2| 6| 0| 3| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | TRIOCT./ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Tissue NOS | + | 1 | Sarcoma | X | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + | 8 | Adenoma | X | 1 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + | 20 | Mesothelioma Malignant | X X | 2 | Interstitial Cell, Adenoma | X X X X X X X X | 15 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Lymph Node | + + + + + | 9 | Iliac, Leukemia Mononuclear | X | 2 | Pancreatic, Leukemia Mononuclear | X | 1 | Renal, Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + + + M + + + + + M + + M + M + + + | 38 | Leukemia Mononuclear | X X X X X X X | 14 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + | 4 | Leukemia Mononuclear | X | 4 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | | 2 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + I + + + I + + + + + + + + M + + + + M + | 42 | Leukemia Mononuclear | X X X X X X | 15 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + | 35 | Fibroma | X | 1 | Leukemia Mononuclear | X X X X X X X X X X X X | 27 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + | 4 | Fibroadenoma | X | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + | 47 | Keratoacanthoma | X | 2 | Squamous Cell Carcinoma | X | 1 | Subcutaneous Tissue, Fibroma | | 2 | Subcutaneous Tissue, Skin, Site of | | | Application, Sarcoma | X X X | 3 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 6 NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE/NNK Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56 __________________________________________________________________________________________________________________________________ | 6| 4| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 5| 6| 3| 7| 7| 6| 5| 6| 6| 6| | | DAY ON TEST | 6| 6| 7| 0| 3| 8| 6| 3| 0| 1| 8| 4| 3| 1| 1| 2| 2| 3| 9| 7| 2| 7| 1| | | | 4| 6| 2| 6| 6| 1| 3| 6| 9| 7| 5| 1| 6| 5| 1| 7| 4| 6| 2| 6| 0| 3| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | TRIOCT./ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + | 48 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Alveolar/Bronchiolar Adenoma | X X X | 3 | Alveolar/Bronchiolar Carcinoma | X | 1 | Cholangiocarcinoma, Metastatic, Liver| | 1 | Leukemia Mononuclear | X X X X X X X | 17 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + M + | 47 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + | 27 | Leukemia Mononuclear | X | 1 | Sarcoma, Metastatic, Tissue NOS | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | X X X X X X X X X X X X | 28 | Mesothelioma Malignant | X X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 7 NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE/NNK Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56 _____________________________________________________________________________________________________________________ | 4| 4| 6| 7| 5| 4| 5| 7| 6| 6| 4| 7| 6| 6| 7| 5| 5| 5| 6| 6| 6| 6| 5| 5| 6| DAY ON TEST | 1| 7| 1| 3| 8| 6| 4| 1| 8| 2| 6| 3| 6| 4| 0| 8| 0| 1| 3| 5| 2| 3| 8| 5| 8| | 7| 8| 2| 6| 2| 6| 4| 0| 3| 0| 0| 6| 2| 1| 4| 9| 1| 8| 3| 5| 5| 5| 9| 7| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| .1MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| NNK/AIR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Intestine Large, Cecum | + | __________________________________________________________________________| Intestine Small, Ileum | | Carcinoma | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X | __________________________________________________________________________| Mesentery | + + + + + + | Leukemia Mononuclear | | __________________________________________________________________________| Oral Mucosa | + + | Pharyngeal, Squamous Cell Papilloma | X | __________________________________________________________________________| Stomach, Glandular | | __________________________________________________________________________| Tongue | | Squamous Cell Papilloma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | | __________________________________________________________________________| Islets, Pancreatic | + + | Adenoma | X X | Carcinoma | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X| Pars Distalis, Leukemia Mononuclear | X | __________________________________________________________________________| Thyroid Gland | + + | Carcinoma | X | Bilateral, C-Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Penis | + + | __________________________________________________________________________| Preputial Gland | + + + + | Carcinoma | X | __________________________________________________________________________| Prostate | + | __________________________________________________________________________| Testes | + + + + + | Interstitial Cell, Adenoma | X X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | | Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node | + + + + | _____________________________________________________________________________________________________________________| Page 8 NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE/NNK Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56 _____________________________________________________________________________________________________________________ | 4| 4| 6| 7| 5| 4| 5| 7| 6| 6| 4| 7| 6| 6| 7| 5| 5| 5| 6| 6| 6| 6| 5| 5| 6| DAY ON TEST | 1| 7| 1| 3| 8| 6| 4| 1| 8| 2| 6| 3| 6| 4| 0| 8| 0| 1| 3| 5| 2| 3| 8| 5| 8| | 7| 8| 2| 6| 2| 6| 4| 0| 3| 0| 0| 6| 2| 1| 4| 9| 1| 8| 3| 5| 5| 5| 9| 7| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| .1MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| NNK/AIR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Leukemia Mononuclear | | Deep Cervical, Leukemia Mononuclear | | Iliac, Leukemia Mononuclear | X | Renal, Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Bronchial | + M M M + M M M + + M + + + + + + + M + + M + + +| Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + | Leukemia Mononuclear | X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + | Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node, Mediastinal | M + + + + M + + + + + + + + + + + + M M + + + + +| Leukemia Mononuclear | X X X X X X X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X X X X X X X X X X X X X | Sarcoma | X | __________________________________________________________________________| Thymus | | Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X | Keratoacanthoma, Multiple | | Squamous Cell Papilloma | X | Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Melanoma Benign | X | Subcutaneous Tissue, Skin, Site of | | Application, Sarcoma | X X| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Leukemia Mononuclear | X X X X X X X X X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| Page 9 NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE/NNK Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56 _____________________________________________________________________________________________________________________ | 4| 4| 6| 7| 5| 4| 5| 7| 6| 6| 4| 7| 6| 6| 7| 5| 5| 5| 6| 6| 6| 6| 5| 5| 6| DAY ON TEST | 1| 7| 1| 3| 8| 6| 4| 1| 8| 2| 6| 3| 6| 4| 0| 8| 0| 1| 3| 5| 2| 3| 8| 5| 8| | 7| 8| 2| 6| 2| 6| 4| 0| 3| 0| 0| 6| 2| 1| 4| 9| 1| 8| 3| 5| 5| 5| 9| 7| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| .1MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| NNK/AIR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + | Leukemia Mononuclear | X X | __________________________________________________________________________| Urinary Bladder | + + | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X | _____________________________________________________________________________________________________________________| Page 10 NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE/NNK Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 5| 6| 4| 7| 6| 7| 5| 6| 7| 6| 6| 7| 6| 5| 6| 6| 6| 5| 7| 5| | | DAY ON TEST | 7| 3| 1| 5| 9| 4| 0| 1| 1| 0| 6| 3| 1| 3| 3| 7| 2| 3| 7| 4| 5| 3| 5| | | | 9| 6| 5| 5| 7| 4| 4| 7| 6| 1| 3| 6| 3| 9| 6| 3| 9| 5| 1| 1| 1| 6| 0| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | .1MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | NNK/AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Intestine Large, Cecum | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + | 1 | Carcinoma | X | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + | 27 | Leukemia Mononuclear | X X X X X X X X X | 20 | __________________________________________________________________________|____________| Mesentery | + + + + | 10 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Oral Mucosa | + + | 4 | Pharyngeal, Squamous Cell Papilloma | X | 2 | __________________________________________________________________________|____________| Stomach, Glandular | + | 1 | __________________________________________________________________________|____________| Tongue | + | 1 | Squamous Cell Papilloma | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + | 5 | Adenoma | | 2 | Carcinoma | X X X | 3 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + | 35 | Leukemia Mononuclear | X X | 3 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X | 32 | Pars Distalis, Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Thyroid Gland | | 2 | Carcinoma | | 1 | Bilateral, C-Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Peritoneum | + + + + + + + + + + + | 24 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Penis | + + | 4 | __________________________________________________________________________|____________| Preputial Gland | + + | 6 | Carcinoma | X | 2 | __________________________________________________________________________|____________| Prostate | + | 2 | __________________________________________________________________________|____________| Testes | + + + + | 9 | Interstitial Cell, Adenoma | X X X X | 9 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 11 NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE/NNK Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 5| 6| 4| 7| 6| 7| 5| 6| 7| 6| 6| 7| 6| 5| 6| 6| 6| 5| 7| 5| | | DAY ON TEST | 7| 3| 1| 5| 9| 4| 0| 1| 1| 0| 6| 3| 1| 3| 3| 7| 2| 3| 7| 4| 5| 3| 5| | | | 9| 6| 5| 5| 7| 4| 4| 7| 6| 1| 3| 6| 3| 9| 6| 3| 9| 5| 1| 1| 1| 6| 0| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | .1MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | NNK/AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + | 1 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Lymph Node | + + + | 7 | Leukemia Mononuclear | X X | 2 | Deep Cervical, Leukemia Mononuclear | X | 1 | Iliac, Leukemia Mononuclear | X | 2 | Renal, Leukemia Mononuclear | X X | 3 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + M M + + + M + + + M + M M + + + + + | 32 | Leukemia Mononuclear | X X X X X X | 13 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + | 8 | Leukemia Mononuclear | X X X | 7 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + | 8 | Leukemia Mononuclear | X X X X | 7 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + M I M + + M + M + + + + + + + M I | 37 | Leukemia Mononuclear | X X X X X X | 16 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + | 32 | Leukemia Mononuclear | X X X X X X X X X X | 25 | Sarcoma | | 1 | __________________________________________________________________________|____________| Thymus | + | 1 | Leukemia Mononuclear | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + | 5 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Keratoacanthoma | X | 2 | Keratoacanthoma, Multiple | X | 1 | Squamous Cell Papilloma | | 1 | Subcutaneous Tissue, Fibroma | X X X | 4 | Subcutaneous Tissue, Melanoma Benign | | 1 | Subcutaneous Tissue, Skin, Site of | | | Application, Sarcoma | X X | 4 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 12 NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE/NNK Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 5| 6| 4| 7| 6| 7| 5| 6| 7| 6| 6| 7| 6| 5| 6| 6| 6| 5| 7| 5| | | DAY ON TEST | 7| 3| 1| 5| 9| 4| 0| 1| 1| 0| 6| 3| 1| 3| 3| 7| 2| 3| 7| 4| 5| 3| 5| | | | 9| 6| 5| 5| 7| 4| 4| 7| 6| 1| 3| 6| 3| 9| 6| 3| 9| 5| 1| 1| 1| 6| 0| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | .1MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | NNK/AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + | 48 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Alveolar/Bronchiolar Adenoma | | 2 | Leukemia Mononuclear | X X X X X X X | 18 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + | 22 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Urinary Bladder | | 2 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | X X X X X X X X X X | 25 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 13 NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE/NNK Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56 _____________________________________________________________________________________________________________________ | 5| 5| 6| 6| 7| 6| 6| 5| 7| 7| 5| 6| 6| 6| 4| 5| 6| 6| 6| 5| 6| 6| 7| 5| 6| DAY ON TEST | 6| 5| 0| 7| 3| 8| 6| 2| 3| 1| 2| 1| 3| 6| 2| 9| 0| 8| 8| 7| 0| 9| 3| 4| 0| | 2| 1| 3| 8| 6| 3| 3| 8| 6| 5| 9| 7| 9| 1| 9| 0| 3| 3| 7| 9| 4| 5| 6| 4| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| NNK/AIR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Intestine Large, Colon | + | __________________________________________________________________________| Intestine Large, Cecum | | __________________________________________________________________________| Intestine Small, Jejunum | + | Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Ileum | + | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | | Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X X| __________________________________________________________________________| Mesentery | + + + + | Leukemia Mononuclear | X | __________________________________________________________________________| Pancreas | | __________________________________________________________________________| Stomach, Forestomach | +| __________________________________________________________________________| Stomach, Glandular | + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + | __________________________________________________________________________| Adrenal Medulla | | Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | | Carcinoma | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + M + + + + + +| Leukemia Mononuclear | | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X| __________________________________________________________________________| Thyroid Gland | + | C-Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Penis | + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + | __________________________________________________________________________| Seminal Vesicle | | Leukemia Mononuclear | | __________________________________________________________________________| Testes | + + + + + + +| Interstitial Cell, Adenoma | X X X X X X| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Deep Cervical, Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| Page 14 NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE/NNK Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56 _____________________________________________________________________________________________________________________ | 5| 5| 6| 6| 7| 6| 6| 5| 7| 7| 5| 6| 6| 6| 4| 5| 6| 6| 6| 5| 6| 6| 7| 5| 6| DAY ON TEST | 6| 5| 0| 7| 3| 8| 6| 2| 3| 1| 2| 1| 3| 6| 2| 9| 0| 8| 8| 7| 0| 9| 3| 4| 0| | 2| 1| 3| 8| 6| 3| 3| 8| 6| 5| 9| 7| 9| 1| 9| 0| 3| 3| 7| 9| 4| 5| 6| 4| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| NNK/AIR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Iliac, Leukemia Mononuclear | X | Pancreatic, Leukemia Mononuclear | X X X X X| Renal, Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Lymph Node, Bronchial | + + + + M M M M M M + + M + I + + + + M M M M M +| Leukemia Mononuclear | X X X X X X X X| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + | Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node, Mediastinal | M + + + + + + + + + + + + + + + + M + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X| __________________________________________________________________________| Thymus | + + | Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X | Trichoepithelioma | X | Sebaceous Gland, Adenoma | | Subcutaneous Tissue, Fibroma | | Subcutaneous Tissue, Skin, Site of | | Application, Sarcoma | X X X X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X X X X | Alveolar/Bronchiolar Adenoma, | | Multiple | X X X X X X X X | Alveolar/Bronchiolar Carcinoma | X X X X X X | Leukemia Mononuclear | X X X X X X X X X X| Sarcoma, Metastatic, Skin | X | Squamous Cell Carcinoma | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| Page 15 NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE/NNK Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56 _____________________________________________________________________________________________________________________ | 5| 5| 6| 6| 7| 6| 6| 5| 7| 7| 5| 6| 6| 6| 4| 5| 6| 6| 6| 5| 6| 6| 7| 5| 6| DAY ON TEST | 6| 5| 0| 7| 3| 8| 6| 2| 3| 1| 2| 1| 3| 6| 2| 9| 0| 8| 8| 7| 0| 9| 3| 4| 0| | 2| 1| 3| 8| 6| 3| 3| 8| 6| 5| 9| 7| 9| 1| 9| 0| 3| 3| 7| 9| 4| 5| 6| 4| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| NNK/AIR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Respiratory Epithelium, Adenoma | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Ureter | + | __________________________________________________________________________| Urinary Bladder | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X X X| _____________________________________________________________________________________________________________________| Page 16 NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE/NNK Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 6| 6| 7| 4| 5| 4| 7| 5| 5| 4| 6| 4| 6| 6| 6| 5| 6| 5| 5| 6| | | DAY ON TEST | 8| 4| 0| 0| 0| 1| 8| 4| 5| 3| 9| 3| 8| 9| 8| 7| 8| 0| 8| 6| 5| 8| 4| | | | 3| 5| 4| 3| 5| 2| 6| 0| 0| 6| 0| 3| 9| 5| 8| 7| 3| 5| 3| 9| 0| 3| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 1 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | NNK/AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Intestine Large, Colon | | 1 | __________________________________________________________________________|____________| Intestine Large, Cecum | + A | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | | 1 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + | 39 | Hepatocellular Adenoma | X | 1 | Leukemia Mononuclear | X X X X X X X X X X X X X X X X | 35 | __________________________________________________________________________|____________| Mesentery | + + + + | 8 | Leukemia Mononuclear | X X | 3 | __________________________________________________________________________|____________| Pancreas | + | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + | 3 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + | 4 | __________________________________________________________________________|____________| Adrenal Medulla | + | 1 | Pheochromocytoma Benign | X | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + | 1 | Carcinoma | X | 1 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + | 34 | Leukemia Mononuclear | X X X | 3 | Pars Distalis, Adenoma | X X X X X X X X X X X X X | 31 | __________________________________________________________________________|____________| Thyroid Gland | | 1 | C-Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Peritoneum | + + + + + + + + + + + + + + + | 32 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Penis | + | 5 | __________________________________________________________________________|____________| Preputial Gland | + + + | 9 | __________________________________________________________________________|____________| Seminal Vesicle | + | 1 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Testes | + + + + + + | 13 | Interstitial Cell, Adenoma | X X X X X X | 12 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 17 NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE/NNK Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 6| 6| 7| 4| 5| 4| 7| 5| 5| 4| 6| 4| 6| 6| 6| 5| 6| 5| 5| 6| | | DAY ON TEST | 8| 4| 0| 0| 0| 1| 8| 4| 5| 3| 9| 3| 8| 9| 8| 7| 8| 0| 8| 6| 5| 8| 4| | | | 3| 5| 4| 3| 5| 2| 6| 0| 0| 6| 0| 3| 9| 5| 8| 7| 3| 5| 3| 9| 0| 3| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 1 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | NNK/AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + | 26 | Leukemia Mononuclear | X | 2 | Deep Cervical, Leukemia Mononuclear | | 2 | Iliac, Leukemia Mononuclear | X | 2 | Pancreatic, Leukemia Mononuclear | X X X X X X X X | 13 | Renal, Leukemia Mononuclear | X X X X X X X | 12 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + M + + + + M + + M + M + M + + + + + M M | 28 | Leukemia Mononuclear | X X X X X X X X X X X X X | 21 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + | 14 | Leukemia Mononuclear | X X X X X | 10 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + | 9 | Leukemia Mononuclear | X X X X X X | 9 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + M + | 45 | Leukemia Mononuclear | X X X X X X X X X X X X X X | 26 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + | 39 | Leukemia Mononuclear | X X X X X X X X X X X X X X X X X | 35 | __________________________________________________________________________|____________| Thymus | + | 3 | Leukemia Mononuclear | X | 3 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + | 5 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + | 47 | Keratoacanthoma | X | 2 | Trichoepithelioma | | 1 | Sebaceous Gland, Adenoma | X | 1 | Subcutaneous Tissue, Fibroma | X | 1 | Subcutaneous Tissue, Skin, Site of | | | Application, Sarcoma | X | 5 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + | 48 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 18 NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE/NNK Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 6| 6| 7| 4| 5| 4| 7| 5| 5| 4| 6| 4| 6| 6| 6| 5| 6| 5| 5| 6| | | DAY ON TEST | 8| 4| 0| 0| 0| 1| 8| 4| 5| 3| 9| 3| 8| 9| 8| 7| 8| 0| 8| 6| 5| 8| 4| | | | 3| 5| 4| 3| 5| 2| 6| 0| 0| 6| 0| 3| 9| 5| 8| 7| 3| 5| 3| 9| 0| 3| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 1 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | NNK/AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Alveolar/Bronchiolar Adenoma | X X X X X | 11 | Alveolar/Bronchiolar Adenoma, | | | Multiple | X | 9 | Alveolar/Bronchiolar Carcinoma | X X | 8 | Leukemia Mononuclear | X X X X X X X X X X | 20 | Sarcoma, Metastatic, Skin | | 1 | Squamous Cell Carcinoma | X | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | | 2 | Respiratory Epithelium, Adenoma | X | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + | 24 | Leukemia Mononuclear | X X X X X | 7 | __________________________________________________________________________|____________| Ureter | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | X X X X X X X X X X X X X X X X X | 37 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 19 NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE/NNK Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56 _____________________________________________________________________________________________________________________ | 7| 5| 6| 4| 4| 6| 6| 5| 6| 6| 3| 3| 1| 7| 6| 5| 7| 7| 5| 5| 5| 6| 7| 6| 6| DAY ON TEST | 2| 5| 0| 5| 4| 3| 6| 0| 7| 7| 8| 3| 9| 1| 2| 8| 3| 0| 2| 9| 1| 4| 0| 1| 1| | 5| 6| 3| 8| 0| 6| 9| 2| 8| 3| 9| 3| 2| 2| 4| 9| 6| 9| 3| 2| 5| 5| 4| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| TRIOCT./ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| OZONE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Intestine Large, Colon | | __________________________________________________________________________| Intestine Large, Rectum | | __________________________________________________________________________| Intestine Large, Cecum | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Mesentery | + + + + +| Leukemia Mononuclear | | Sarcoma | X| Sarcoma, Metastatic, Tissue NOS | X | __________________________________________________________________________| Oral Mucosa | + | __________________________________________________________________________| Pancreas | + | Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Forestomach | + | __________________________________________________________________________| Stomach, Glandular | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | __________________________________________________________________________| Heart | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + +| Adenoma | X | __________________________________________________________________________| Islets, Pancreatic | + | Carcinoma | X | __________________________________________________________________________| Parathyroid Gland | | __________________________________________________________________________| Pituitary Gland | + + + + + M + + + + + +| Schwannoma Malignant, Metastatic, | | Tissue NOS | | Pars Distalis, Adenoma | X X X X X X X X X X X| __________________________________________________________________________| Thyroid Gland | + | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | + + + + + + + + + + + + + +| __________________________________________________________________________| Tissue NOS | + + + + + | Sarcoma | X X X X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Penis | +| __________________________________________________________________________| Preputial Gland | + + + + + | Adenoma | | Leukemia Mononuclear | | __________________________________________________________________________| Prostate | + | __________________________________________________________________________| Testes | + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| Page 20 NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE/NNK Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56 _____________________________________________________________________________________________________________________ | 7| 5| 6| 4| 4| 6| 6| 5| 6| 6| 3| 3| 1| 7| 6| 5| 7| 7| 5| 5| 5| 6| 7| 6| 6| DAY ON TEST | 2| 5| 0| 5| 4| 3| 6| 0| 7| 7| 8| 3| 9| 1| 2| 8| 3| 0| 2| 9| 1| 4| 0| 1| 1| | 5| 6| 3| 8| 0| 6| 9| 2| 8| 3| 9| 3| 2| 2| 4| 9| 6| 9| 3| 2| 5| 5| 4| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| TRIOCT./ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| OZONE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Interstitial Cell, Adenoma | X X X X X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Lymph Node | + + + | Iliac, Leukemia Mononuclear | X | Pancreatic, Leukemia Mononuclear | X X | Renal, Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Bronchial | M M M + + + + M + + + + M + M + + M + M + M M M +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Lymph Node, Mandibular | + | Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Mesenteric | | Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Mediastinal | + I + + + + + + + + M + + + + M + M + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X | __________________________________________________________________________| Thymus | + | Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X X X | Squamous Cell Papilloma | | Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Skin, Site of | | Application, Sarcoma | X X X X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | | Leukemia Mononuclear | | Cranial Nerve, Schwannoma Malignant | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Leukemia Mononuclear | X X X X X X X X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pleura | + | _____________________________________________________________________________________________________________________| Page 21 NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE/NNK Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56 _____________________________________________________________________________________________________________________ | 7| 5| 6| 4| 4| 6| 6| 5| 6| 6| 3| 3| 1| 7| 6| 5| 7| 7| 5| 5| 5| 6| 7| 6| 6| DAY ON TEST | 2| 5| 0| 5| 4| 3| 6| 0| 7| 7| 8| 3| 9| 1| 2| 8| 3| 0| 2| 9| 1| 4| 0| 1| 1| | 5| 6| 3| 8| 0| 6| 9| 2| 8| 3| 9| 3| 2| 2| 4| 9| 6| 9| 3| 2| 5| 5| 4| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| TRIOCT./ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| OZONE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Mesothelioma Malignant | | Sarcoma, Metastatic, Tissue NOS | X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + | Leukemia Mononuclear | X | __________________________________________________________________________| Urinary Bladder | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X | Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| Page 22 NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE/NNK Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56 __________________________________________________________________________________________________________________________________ | 7| 5| 6| 6| 6| 7| 7| 5| 5| 6| 6| 6| 6| 2| 6| 6| 7| 5| 7| 5| 6| 5| 4| | | DAY ON TEST | 3| 9| 0| 3| 9| 3| 0| 8| 5| 6| 5| 3| 3| 5| 3| 1| 2| 3| 1| 2| 3| 6| 8| | | | 6| 0| 5| 5| 4| 6| 5| 0| 0| 1| 9| 4| 4| 3| 1| 4| 2| 7| 8| 9| 5| 0| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A | TRIOCT./ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | OZONE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Intestine Large, Colon | + | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + | 1 | __________________________________________________________________________|____________| Intestine Large, Cecum | A | | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + | 28 | Leukemia Mononuclear | X X X X X X X X X X | 18 | __________________________________________________________________________|____________| Mesentery | + + + | 8 | Leukemia Mononuclear | X | 1 | Sarcoma | | 1 | Sarcoma, Metastatic, Tissue NOS | | 1 | __________________________________________________________________________|____________| Oral Mucosa | | 1 | __________________________________________________________________________|____________| Pancreas | | 1 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + | 2 | __________________________________________________________________________|____________| Stomach, Glandular | + + | 3 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 1 | __________________________________________________________________________|____________| Heart | + | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | | 3 | Adenoma | | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | | 1 | Carcinoma | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + | 1 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + | 29 | Schwannoma Malignant, Metastatic, | | | Tissue NOS | X | 1 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X | 28 | __________________________________________________________________________|____________| Thyroid Gland | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Peritoneum | + + + + + + + + + + + + + + + + | 30 | __________________________________________________________________________|____________| Tissue NOS | | 5 | Sarcoma | | 4 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Penis | + + | 3 | __________________________________________________________________________|____________| Preputial Gland | + + + | 8 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 23 NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE/NNK Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56 __________________________________________________________________________________________________________________________________ | 7| 5| 6| 6| 6| 7| 7| 5| 5| 6| 6| 6| 6| 2| 6| 6| 7| 5| 7| 5| 6| 5| 4| | | DAY ON TEST | 3| 9| 0| 3| 9| 3| 0| 8| 5| 6| 5| 3| 3| 5| 3| 1| 2| 3| 1| 2| 3| 6| 8| | | | 6| 0| 5| 5| 4| 6| 5| 0| 0| 1| 9| 4| 4| 3| 1| 4| 2| 7| 8| 9| 5| 0| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A | TRIOCT./ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | OZONE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Adenoma | X | 1 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Prostate | | 1 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + | 24 | Leukemia Mononuclear | X | 1 | Interstitial Cell, Adenoma | X X X X X X X X X X X X | 20 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Lymph Node | + + + + + + + | 10 | Iliac, Leukemia Mononuclear | X | 2 | Pancreatic, Leukemia Mononuclear | X X X | 5 | Renal, Leukemia Mononuclear | X X | 3 | __________________________________________________________________________|____________| Lymph Node, Bronchial | M M M + + M M M M + + + M + M M M M M + M + + | 23 | Leukemia Mononuclear | X X X X X X | 12 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + | 7 | Leukemia Mononuclear | X X | 2 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + | 3 | Leukemia Mononuclear | X X | 2 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + M + + + + + + + | 43 | Leukemia Mononuclear | X X X X X X X X | 18 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + | 33 | Leukemia Mononuclear | X X X X X X X X X X X X | 24 | __________________________________________________________________________|____________| Thymus | | 1 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + | 2 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Keratoacanthoma | X | 4 | Squamous Cell Papilloma | X | 1 | Subcutaneous Tissue, Fibroma | X | 2 | Subcutaneous Tissue, Skin, Site of | | | Application, Sarcoma | X | 5 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 24 NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE/NNK Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56 __________________________________________________________________________________________________________________________________ | 7| 5| 6| 6| 6| 7| 7| 5| 5| 6| 6| 6| 6| 2| 6| 6| 7| 5| 7| 5| 6| 5| 4| | | DAY ON TEST | 3| 9| 0| 3| 9| 3| 0| 8| 5| 6| 5| 3| 3| 5| 3| 1| 2| 3| 1| 2| 3| 6| 8| | | | 6| 0| 5| 5| 4| 6| 5| 0| 0| 1| 9| 4| 4| 3| 1| 4| 2| 7| 8| 9| 5| 0| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A | TRIOCT./ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | OZONE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | Leukemia Mononuclear | X | 1 | Cranial Nerve, Schwannoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + | 48 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Alveolar/Bronchiolar Adenoma | X | 1 | Leukemia Mononuclear | X X X X X X X X X X X | 21 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 | __________________________________________________________________________|____________| Pleura | + | 2 | Mesothelioma Malignant | X | 1 | Sarcoma, Metastatic, Tissue NOS | | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + A + + + + + + | 47 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + | 15 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + | 2 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | X X X X X X X X X X X X X | 25 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 25 NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE/NNK Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56 _____________________________________________________________________________________________________________________ | 7| 6| 6| 5| 7| 6| 4| 6| 6| 6| 5| 5| 2| 7| 6| 6| 6| 5| 5| 5| 4| 6| 5| 7| 6| DAY ON TEST | 3| 0| 7| 4| 3| 9| 6| 7| 9| 6| 8| 6| 3| 1| 0| 6| 8| 6| 5| 6| 4| 8| 5| 1| 6| | 6| 4| 3| 9| 6| 7| 0| 1| 8| 9| 3| 9| 4| 0| 5| 2| 3| 7| 0| 5| 4| 0| 2| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| .1M/KNNK | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| /OZONE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Intestine Large, Cecum | + | Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Ileum | + | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X X| __________________________________________________________________________| Mesentery | + + + + + | Leukemia Mononuclear | X X X | Sarcoma | | __________________________________________________________________________| Stomach, Forestomach | + | __________________________________________________________________________| Stomach, Glandular | + | __________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + | Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + | __________________________________________________________________________| Parathyroid Gland | + | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + | Leukemia Mononuclear | X X X | Pars Distalis, Adenoma | X X X X X X X X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | + + + + + + + + + + + + + + +| Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | | Mesothelioma Malignant | | __________________________________________________________________________| Penis | + | __________________________________________________________________________| Preputial Gland | + | __________________________________________________________________________| Prostate | + | __________________________________________________________________________| Testes | + + + + + + + + + + + +| Leukemia Mononuclear | X | Mesothelioma Malignant | | Interstitial Cell, Adenoma | X X X X X X X X X X X| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + | Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node | + + + + + + + + | Leukemia Mononuclear | X X | Deep Cervical, Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| Page 26 NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE/NNK Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56 _____________________________________________________________________________________________________________________ | 7| 6| 6| 5| 7| 6| 4| 6| 6| 6| 5| 5| 2| 7| 6| 6| 6| 5| 5| 5| 4| 6| 5| 7| 6| DAY ON TEST | 3| 0| 7| 4| 3| 9| 6| 7| 9| 6| 8| 6| 3| 1| 0| 6| 8| 6| 5| 6| 4| 8| 5| 1| 6| | 6| 4| 3| 9| 6| 7| 0| 1| 8| 9| 3| 9| 4| 0| 5| 2| 3| 7| 0| 5| 4| 0| 2| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| .1M/KNNK | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| /OZONE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Iliac, Leukemia Mononuclear | X | Pancreatic, Leukemia Mononuclear | X | Renal, Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node, Bronchial | + M + + M M + + + M M + M M + M + M + M + + + + M| Leukemia Mononuclear | X X X X X X X X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + | Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + | Leukemia Mononuclear | X X X X X X X X X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X X| Mesothelioma Malignant | | __________________________________________________________________________| Thymus | + + + | Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | X | Keratoacanthoma | | Subcutaneous Tissue, Skin, Site of | | Application, Sarcoma | X X | Subcutaneous Tissue, Skin, Site of | | Application, Sarcoma, Multiple | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Adenoma, | | Multiple | | Leukemia Mononuclear | X X X X X X X X X X X X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| Page 27 NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE/NNK Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56 _____________________________________________________________________________________________________________________ | 7| 6| 6| 5| 7| 6| 4| 6| 6| 6| 5| 5| 2| 7| 6| 6| 6| 5| 5| 5| 4| 6| 5| 7| 6| DAY ON TEST | 3| 0| 7| 4| 3| 9| 6| 7| 9| 6| 8| 6| 3| 1| 0| 6| 8| 6| 5| 6| 4| 8| 5| 1| 6| | 6| 4| 3| 9| 6| 7| 0| 1| 8| 9| 3| 9| 4| 0| 5| 2| 3| 7| 0| 5| 4| 0| 2| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| .1M/KNNK | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| /OZONE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + | Leukemia Mononuclear | X X X | __________________________________________________________________________| Urinary Bladder | + + | Leukemia Mononuclear | X | Papilloma | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X X X| Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| Page 28 NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE/NNK Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 6| 7| 6| 6| 5| 4| 7| 4| 5| 6| 6| 6| 7| 6| 7| 7| 6| 7| 4| 6| | | DAY ON TEST | 8| 1| 3| 2| 3| 3| 6| 7| 9| 3| 4| 6| 4| 3| 0| 0| 8| 3| 3| 3| 2| 1| 8| | | | 1| 3| 6| 0| 3| 5| 9| 5| 6| 6| 4| 7| 1| 8| 4| 3| 3| 6| 6| 2| 5| 6| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T | ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A | .1M/KNNK | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | /OZONE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Intestine Large, Cecum | | 1 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + | 36 | Leukemia Mononuclear | X X X X X X X X X X X X X X | 30 | __________________________________________________________________________|____________| Mesentery | + + + + + + | 11 | Leukemia Mononuclear | | 3 | Sarcoma | X X | 2 | __________________________________________________________________________|____________| Stomach, Forestomach | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | | 1 | __________________________________________________________________________|____________| Tooth | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + | 2 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | | 1 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + | 27 | Leukemia Mononuclear | X | 4 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X | 23 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Peritoneum | + + + + + + + + + + + + + + + + | 31 | Mesothelioma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + | 1 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________|____________| Penis | | 1 | __________________________________________________________________________|____________| Preputial Gland | + | 2 | __________________________________________________________________________|____________| Prostate | + | 2 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + | 25 | Leukemia Mononuclear | | 1 | Mesothelioma Malignant | X | 1 | Interstitial Cell, Adenoma | X X X X X X X X X X X X | 23 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 29 NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE/NNK Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 6| 7| 6| 6| 5| 4| 7| 4| 5| 6| 6| 6| 7| 6| 7| 7| 6| 7| 4| 6| | | DAY ON TEST | 8| 1| 3| 2| 3| 3| 6| 7| 9| 3| 4| 6| 4| 3| 0| 0| 8| 3| 3| 3| 2| 1| 8| | | | 1| 3| 6| 0| 3| 5| 9| 5| 6| 6| 4| 7| 1| 8| 4| 3| 3| 6| 6| 2| 5| 6| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T | ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A | .1M/KNNK | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | /OZONE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Bone Marrow | | 1 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Lymph Node | + + | 10 | Leukemia Mononuclear | | 2 | Deep Cervical, Leukemia Mononuclear | | 1 | Iliac, Leukemia Mononuclear | | 1 | Pancreatic, Leukemia Mononuclear | | 1 | Renal, Leukemia Mononuclear | | 3 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + M + + + M M M M + + + I + + + M M M + M M | 26 | Leukemia Mononuclear | X | 10 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + | 7 | Leukemia Mononuclear | | 6 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + | 11 | Leukemia Mononuclear | X | 11 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + M + + M + + + + + + + + + M + + M + M + | 43 | Leukemia Mononuclear | X X X X X X X | 21 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + | 37 | Leukemia Mononuclear | X X X X X X X X X X X X X X X | 34 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________|____________| Thymus | | 3 | Leukemia Mononuclear | | 3 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Basal Cell Adenoma | | 1 | Keratoacanthoma | X X | 2 | Subcutaneous Tissue, Skin, Site of | | | Application, Sarcoma | X X X | 5 | Subcutaneous Tissue, Skin, Site of | | | Application, Sarcoma, Multiple | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + | 48 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 30 NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE/NNK Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 6| 7| 6| 6| 5| 4| 7| 4| 5| 6| 6| 6| 7| 6| 7| 7| 6| 7| 4| 6| | | DAY ON TEST | 8| 1| 3| 2| 3| 3| 6| 7| 9| 3| 4| 6| 4| 3| 0| 0| 8| 3| 3| 3| 2| 1| 8| | | | 1| 3| 6| 0| 3| 5| 9| 5| 6| 6| 4| 7| 1| 8| 4| 3| 3| 6| 6| 2| 5| 6| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T | ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A | .1M/KNNK | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | /OZONE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Alveolar/Bronchiolar Adenoma | | 2 | Alveolar/Bronchiolar Adenoma, | | | Multiple | X | 1 | Leukemia Mononuclear | X X X X X X | 20 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + I + + + + + + + + | 47 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Zymbal's Gland | + + + | 3 | Carcinoma | X X X | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + | 20 | Leukemia Mononuclear | | 3 | __________________________________________________________________________|____________| Urinary Bladder | + | 3 | Leukemia Mononuclear | | 1 | Papilloma | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | X X X X X X X X X X X X X X X | 35 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 31 NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE/NNK Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56 _____________________________________________________________________________________________________________________ | 6| 5| 5| 5| 2| 4| 7| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 4| 6| 6| 6| 7| 6| 5| DAY ON TEST | 1| 6| 5| 5| 5| 5| 3| 8| 4| 0| 0| 8| 8| 6| 3| 4| 1| 5| 7| 9| 6| 4| 2| 8| 9| | 7| 2| 8| 7| 3| 6| 6| 3| 1| 3| 3| 7| 3| 9| 6| 0| 0| 5| 0| 7| 1| 0| 5| 3| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1M/K NNK | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| /OZONE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Intestine Large, Cecum | + | __________________________________________________________________________| Intestine Small, Ileum | | Leukemia Mononuclear | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X X X | __________________________________________________________________________| Mesentery | + + + + | __________________________________________________________________________| Stomach, Forestomach | | __________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Medulla | + | Pheochromocytoma Malignant | X | __________________________________________________________________________| Parathyroid Gland | + | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X| __________________________________________________________________________| Thyroid Gland | | C-Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | + + + + + + + + + + + + +| __________________________________________________________________________| Tissue NOS | | Abdominal, Osteosarcoma | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Penis | + | __________________________________________________________________________| Preputial Gland | + | __________________________________________________________________________| Testes | + + + + + + + + + + | Interstitial Cell, Adenoma | X X X X X X X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Lymph Node | + + + + + +| Leukemia Mononuclear | X X | Deep Cervical, Leukemia Mononuclear | X | Iliac, Leukemia Mononuclear | X | Inguinal, Leukemia Mononuclear | | Lumbar, Leukemia Mononuclear | X | Pancreatic, Leukemia Mononuclear | X X | Renal, Leukemia Mononuclear | X X X X| __________________________________________________________________________| Lymph Node, Bronchial | + M + + + + + M + M + + + + M + + + + M + M + + +| Alveolar/Bronchiolar Carcinoma, | | _____________________________________________________________________________________________________________________| Page 32 NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE/NNK Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56 _____________________________________________________________________________________________________________________ | 6| 5| 5| 5| 2| 4| 7| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 4| 6| 6| 6| 7| 6| 5| DAY ON TEST | 1| 6| 5| 5| 5| 5| 3| 8| 4| 0| 0| 8| 8| 6| 3| 4| 1| 5| 7| 9| 6| 4| 2| 8| 9| | 7| 2| 8| 7| 3| 6| 6| 3| 1| 3| 3| 7| 3| 9| 6| 0| 0| 5| 0| 7| 1| 0| 5| 3| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1M/K NNK | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| /OZONE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Metastatic, Lung | X | Leukemia Mononuclear | X X X X X X X X X X X X | Squamous Cell Carcinoma, Metastatic, | | Lung | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + +| Leukemia Mononuclear | X X X X X X X| __________________________________________________________________________| Lymph Node, Mesenteric | + + + | Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + M + + + + + + + + M + M + M + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | Leukemia Mononuclear | X X X X X X X X X X X | Squamous Cell Carcinoma, Metastatic, | | Lung | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X| __________________________________________________________________________| Thymus | + | Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + | Fibroadenoma | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X X | Squamous Cell Papilloma | X X | Sebaceous Gland, Adenoma | X | Subcutaneous Tissue, Fibroma | | Subcutaneous Tissue, Skin, Site of | | Application, Osteosarcoma | X | Subcutaneous Tissue, Skin, Site of | | Application, Sarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X X X X X | Alveolar/Bronchiolar Adenoma, | | Multiple | X X X X X X | _____________________________________________________________________________________________________________________| Page 33 NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE/NNK Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56 _____________________________________________________________________________________________________________________ | 6| 5| 5| 5| 2| 4| 7| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 4| 6| 6| 6| 7| 6| 5| DAY ON TEST | 1| 6| 5| 5| 5| 5| 3| 8| 4| 0| 0| 8| 8| 6| 3| 4| 1| 5| 7| 9| 6| 4| 2| 8| 9| | 7| 2| 8| 7| 3| 6| 6| 3| 1| 3| 3| 7| 3| 9| 6| 0| 0| 5| 0| 7| 1| 0| 5| 3| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1M/K NNK | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| /OZONE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Alveolar/Bronchiolar Carcinoma | X X X X X X | Alveolar/Bronchiolar Carcinoma, | | Multiple | X X | Leukemia Mononuclear | X X X X X X X X X X X X X X | Sarcoma, Metastatic, Skin | X | Squamous Cell Carcinoma | X | Mediastinum, Alveolar/Bronchiolar | | Carcinoma, Metastatic, Lung | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + A + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + A + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | +| __________________________________________________________________________| Zymbal's Gland | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Transitional Epithelium, Carcinoma | X | __________________________________________________________________________| Urinary Bladder | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X X X| _____________________________________________________________________________________________________________________| Page 34 NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE/NNK Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 7| 7| 6| 7| 7| 4| 6| 5| 6| 5| 6| 6| 5| 6| 6| 7| 5| 6| 4| 7| | | DAY ON TEST | 0| 3| 5| 3| 0| 3| 1| 3| 1| 0| 8| 6| 8| 7| 1| 8| 3| 8| 0| 8| 7| 0| 0| | | | 3| 6| 7| 6| 5| 5| 2| 6| 6| 2| 5| 9| 0| 1| 3| 2| 5| 7| 0| 1| 8| 3| 4| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 1M/K NNK | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | /OZONE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Intestine Large, Cecum | + | 2 | __________________________________________________________________________|____________| Intestine Small, Ileum | + | 1 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + | 42 | Leukemia Mononuclear | X X X X X X X X X X X X X X X X X | 34 | __________________________________________________________________________|____________| Mesentery | + + + + | 8 | __________________________________________________________________________|____________| Stomach, Forestomach | + + | 2 | __________________________________________________________________________|____________| Tooth | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | | 2 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Medulla | | 1 | Pheochromocytoma Malignant | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | | 1 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + | 30 | Leukemia Mononuclear | X X X X | 4 | Pars Distalis, Adenoma | X X X X X X X X X | 25 | __________________________________________________________________________|____________| Thyroid Gland | + | 1 | C-Cell, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Peritoneum | + + + + + + + + + + + + + | 26 | __________________________________________________________________________|____________| Tissue NOS | + | 1 | Abdominal, Osteosarcoma | X | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Penis | + | 2 | __________________________________________________________________________|____________| Preputial Gland | + + | 3 | __________________________________________________________________________|____________| Testes | + + + + + + + + + | 19 | Interstitial Cell, Adenoma | X X X X X X X X X | 19 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + | 17 | Leukemia Mononuclear | X X | 4 | Deep Cervical, Leukemia Mononuclear | X X X | 4 | Iliac, Leukemia Mononuclear | X X | 3 | Inguinal, Leukemia Mononuclear | X X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 35 NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE/NNK Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 7| 7| 6| 7| 7| 4| 6| 5| 6| 5| 6| 6| 5| 6| 6| 7| 5| 6| 4| 7| | | DAY ON TEST | 0| 3| 5| 3| 0| 3| 1| 3| 1| 0| 8| 6| 8| 7| 1| 8| 3| 8| 0| 8| 7| 0| 0| | | | 3| 6| 7| 6| 5| 5| 2| 6| 6| 2| 5| 9| 0| 1| 3| 2| 5| 7| 0| 1| 8| 3| 4| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 1M/K NNK | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | /OZONE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Lumbar, Leukemia Mononuclear | | 1 | Pancreatic, Leukemia Mononuclear | X X X X X X | 8 | Renal, Leukemia Mononuclear | X X X X X X X X | 12 | __________________________________________________________________________|____________| Lymph Node, Bronchial | M M + M M M + M + M M M M + + + + M + M + + + | 30 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | | 1 | Leukemia Mononuclear | X X X X X X X X | 20 | Squamous Cell Carcinoma, Metastatic, | | | Lung | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + | 15 | Leukemia Mononuclear | X X X X X | 12 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + | 8 | Leukemia Mononuclear | X X X X X | 8 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + M + + + + + + + + + + | 43 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | | 1 | Leukemia Mononuclear | X X X X X X X X X X X X X | 24 | Squamous Cell Carcinoma, Metastatic, | | | Lung | | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + | 39 | Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X X | 37 | __________________________________________________________________________|____________| Thymus | + | 2 | Leukemia Mononuclear | X | 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + | 4 | Fibroadenoma | | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Keratoacanthoma | | 2 | Squamous Cell Papilloma | | 2 | Sebaceous Gland, Adenoma | | 1 | Subcutaneous Tissue, Fibroma | X | 1 | Subcutaneous Tissue, Skin, Site of | | | Application, Osteosarcoma | | 1 | Subcutaneous Tissue, Skin, Site of | | | Application, Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 36 NTP Experiment-Test: 88034-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE/NNK Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:25:56 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 7| 7| 6| 7| 7| 4| 6| 5| 6| 5| 6| 6| 5| 6| 6| 7| 5| 6| 4| 7| | | DAY ON TEST | 0| 3| 5| 3| 0| 3| 1| 3| 1| 0| 8| 6| 8| 7| 1| 8| 3| 8| 0| 8| 7| 0| 0| | | | 3| 6| 7| 6| 5| 5| 2| 6| 6| 2| 5| 9| 0| 1| 3| 2| 5| 7| 0| 1| 8| 3| 4| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 1M/K NNK | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | /OZONE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + | 48 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Alveolar/Bronchiolar Adenoma | X X X X X X X | 14 | Alveolar/Bronchiolar Adenoma, | | | Multiple | X X X | 9 | Alveolar/Bronchiolar Carcinoma | X X X | 9 | Alveolar/Bronchiolar Carcinoma, | | | Multiple | | 2 | Leukemia Mononuclear | X X X X X X X X X X | 24 | Sarcoma, Metastatic, Skin | | 1 | Squamous Cell Carcinoma | X | 2 | Mediastinum, Alveolar/Bronchiolar | | | Carcinoma, Metastatic, Lung | | 1 | __________________________________________________________________________|____________| Nose | A + + + + + + + + + + + + + + + + + + + + + + | 46 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Trachea | A + + + + + + + + + + + + + + + + + + + + + + | 46 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + + | 4 | __________________________________________________________________________|____________| Zymbal's Gland | + | 1 | Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + | 25 | Leukemia Mononuclear | X X X X | 7 | Transitional Epithelium, Carcinoma | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X X X | 40 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 37 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------