TDMS Study 88034-07 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) OZONE/NNK NTP Experiment-Test: 88034-07 Report: PEIRPT05 Study Type: CHRONIC Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:01:32 Facility: Battelle Northwest Chemical CAS #: 10028-15-6 Lock Date: 02/17/93 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 88034-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC OZONE/NNK Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:01:32 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE TRIOCT./ .1MG/KG TRIOCT./ .1M/KNNK 1M/K NNK 1 MG/KG AIR NNK/AIR OZONE /OZONE /OZONE NNK/AIR ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 48 48 48 48 48 48 Early Deaths Moribund Sacrifice 36 40 36 38 36 41 Natural Death 4 2 9 4 7 3 Survivors Terminal Sacrifice 8 6 3 6 5 4 Animals Examined Microscopically 48 48 48 48 48 48 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Rectum (1) (1) Polyp Adenomatous 1 (100%) Intestine Large, Cecum (1) (1) (2) (1) Intestine Small, Jejunum (1) Intestine Small, Ileum (1) (1) (1) (1) Carcinoma 1 (100%) Liver (26) (27) (28) (36) (42) (39) Cholangiocarcinoma 1 (4%) Hepatocellular Adenoma 1 (3%) Mesentery (8) (10) (8) (11) (8) (8) Sarcoma 1 (13%) 2 (18%) Sarcoma, Metastatic, Tissue NOS 1 (13%) Oral Mucosa (4) (1) Pharyngeal, Squamous Cell Papilloma 2 (50%) Pancreas (1) (1) (1) Tongue (1) (1) Squamous Cell Papilloma 1 (100%) 1 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (1) (1) (1) (2) (2) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (4) (1) (3) (1) (4) Adenoma 1 (33%) Adrenal Medulla (4) (1) (1) Pheochromocytoma Malignant 1 (25%) 1 (100%) Pheochromocytoma Benign 3 (75%) 1 (100%) Islets, Pancreatic (1) (5) (1) (1) Adenoma 2 (40%) Page 2 NTP Experiment-Test: 88034-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC OZONE/NNK Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:01:32 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE TRIOCT./ .1MG/KG TRIOCT./ .1M/KNNK 1M/K NNK 1 MG/KG AIR NNK/AIR OZONE /OZONE /OZONE NNK/AIR ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont Carcinoma 1 (100%) 3 (60%) 1 (100%) 1 (100%) Pituitary Gland (34) (35) (29) (27) (30) (34) Schwannoma Malignant, Metastatic, Tissue NOS 1 (3%) Pars Distalis, Adenoma 32 (94%) 32 (91%) 28 (97%) 23 (85%) 25 (83%) 31 (91%) Pars Distalis, Carcinoma 1 (3%) Thyroid Gland (3) (2) (1) (1) (1) Carcinoma 1 (33%) 1 (50%) Bilateral, C-Cell, Adenoma 1 (50%) C-Cell, Adenoma 1 (100%) C-Cell, Carcinoma 1 (33%) 1 (100%) Follicular Cell, Adenoma 1 (33%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM Peritoneum (32) (24) (30) (31) (26) (32) Tissue NOS (1) (5) (1) Sarcoma 1 (100%) 4 (80%) Abdominal, Osteosarcoma 1 (100%) ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (1) (1) Preputial Gland (8) (6) (8) (2) (3) (9) Adenoma 1 (13%) 1 (13%) Carcinoma 2 (33%) Seminal Vesicle (1) Testes (20) (9) (24) (25) (19) (13) Interstitial Cell, Adenoma 15 (75%) 9 (100%) 20 (83%) 23 (92%) 19 (100%) 12 (92%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (1) (1) Lymph Node (9) (7) (10) (10) (17) (26) Lymph Node, Bronchial (38) (32) (23) (26) (30) (28) Alveolar/Bronchiolar Carcinoma, Metastatic, Lung 1 (3%) Squamous Cell Carcinoma, Metastatic, Lung 1 (3%) Lymph Node, Mandibular (4) (8) (7) (7) (15) (14) Lymph Node, Mesenteric (2) (8) (3) (11) (8) (9) Lymph Node, Mediastinal (42) (37) (43) (43) (43) (45) Alveolar/Bronchiolar Carcinoma, Metastatic, Lung 1 (2%) Squamous Cell Carcinoma, Metastatic, Lung 1 (2%) Spleen (35) (32) (33) (37) (39) (39) Page 3 NTP Experiment-Test: 88034-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC OZONE/NNK Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:01:32 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE TRIOCT./ .1MG/KG TRIOCT./ .1M/KNNK 1M/K NNK 1 MG/KG AIR NNK/AIR OZONE /OZONE /OZONE NNK/AIR ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont Fibroma 1 (3%) Sarcoma 1 (3%) Thymus (1) (1) (3) (2) (3) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (4) (5) (2) (4) (5) Fibroadenoma 1 (25%) 1 (25%) Skin (47) (47) (48) (48) (48) (47) Basal Cell Adenoma 1 (2%) Keratoacanthoma 2 (4%) 2 (4%) 4 (8%) 2 (4%) 2 (4%) 2 (4%) Keratoacanthoma, Multiple 1 (2%) Squamous Cell Carcinoma 1 (2%) Squamous Cell Papilloma 1 (2%) 1 (2%) 2 (4%) Trichoepithelioma 1 (2%) Sebaceous Gland, Adenoma 1 (2%) 1 (2%) Subcutaneous Tissue, Fibroma 2 (4%) 4 (9%) 2 (4%) 1 (2%) 1 (2%) Subcutaneous Tissue, Melanoma Benign 1 (2%) Subcutaneous Tissue, Skin, Site of Application, Osteosarcoma 1 (2%) Subcutaneous Tissue, Skin, Site of Application, Sarcoma 3 (6%) 4 (9%) 5 (10%) 5 (10%) 1 (2%) 5 (11%) Subcutaneous Tissue, Skin, Site of Application, Sarcoma, Multiple 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (2) (1) Cranial Nerve, Schwannoma Malignant 1 (50%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (48) (48) (48) (48) (48) (48) Alveolar/Bronchiolar Adenoma 3 (6%) 2 (4%) 1 (2%) 2 (4%) 14 (29%) 11 (23%) Alveolar/Bronchiolar Adenoma, Multiple 1 (2%) 9 (19%) 9 (19%) Alveolar/Bronchiolar Carcinoma 1 (2%) 9 (19%) 8 (17%) Alveolar/Bronchiolar Carcinoma, Multiple 2 (4%) Cholangiocarcinoma, Metastatic, Liver 1 (2%) Sarcoma, Metastatic, Skin 1 (2%) 1 (2%) Page 4 NTP Experiment-Test: 88034-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC OZONE/NNK Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:01:32 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE TRIOCT./ .1MG/KG TRIOCT./ .1M/KNNK 1M/K NNK 1 MG/KG AIR NNK/AIR OZONE /OZONE /OZONE NNK/AIR ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont Squamous Cell Carcinoma 2 (4%) 1 (2%) Mediastinum, Alveolar/Bronchiolar Carcinoma, Metastatic, Lung 1 (2%) Nose (47) (48) (48) (48) (46) (48) Respiratory Epithelium, Adenoma 1 (2%) Pleura (2) Sarcoma, Metastatic, Tissue NOS 1 (50%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Zymbal's Gland (3) (1) Carcinoma 3 (100%) 1 (100%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (27) (22) (15) (20) (25) (24) Sarcoma, Metastatic, Tissue NOS 1 (4%) Transitional Epithelium, Carcinoma 1 (4%) Urinary Bladder (2) (2) (3) (1) (1) Papilloma 1 (33%) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(48) *(48) *(48) *(48) *(48) *(48) Leukemia Mononuclear 28 (58%) 25 (52%) 25 (52%) 35 (73%) 40 (83%) 37 (77%) Mesothelioma Malignant 2 (4%) 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 5 NTP Experiment-Test: 88034-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC OZONE/NNK Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:01:32 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE TRIOCT./ .1MG/KG TRIOCT./ .1M/KNNK 1M/K NNK 1 MG/KG AIR NNK/AIR OZONE /OZONE /OZONE NNK/AIR ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 48 48 45 47 47 48 Total Primary Neoplasms 105 95 96 100 134 124 Total Animals with Benign Neoplasms 41 40 39 37 37 42 Total Benign Neoplasms 63 58 58 53 75 71 Total Animals with Malignant Neoplasms 36 30 34 41 43 40 Total Malignant Neoplasms 42 37 38 47 59 53 Total Animals with Metastatic Neoplasms 2 3 3 1 Total Metastatic Neoplasm 2 3 6 1 Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 6 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------