TDMS Study 88034-07 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
OZONE/NNK
NTP Experiment-Test: 88034-07 Report: PEIRPT05
Study Type: CHRONIC Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:01:32
Facility: Battelle Northwest
Chemical CAS #: 10028-15-6
Lock Date: 02/17/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 88034-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OZONE/NNK Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:01:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE TRIOCT./ .1MG/KG TRIOCT./ .1M/KNNK 1M/K NNK 1 MG/KG
AIR NNK/AIR OZONE /OZONE /OZONE NNK/AIR
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DISPOSITION SUMMARY
Animals Initially in Study 48 48 48 48 48 48
Early Deaths
Moribund Sacrifice 36 40 36 38 36 41
Natural Death 4 2 9 4 7 3
Survivors
Terminal Sacrifice 8 6 3 6 5 4
Animals Examined Microscopically 48 48 48 48 48 48
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ALIMENTARY SYSTEM
Intestine Large, Rectum (1) (1)
Polyp Adenomatous 1 (100%)
Intestine Large, Cecum (1) (1) (2) (1)
Intestine Small, Jejunum (1)
Intestine Small, Ileum (1) (1) (1) (1)
Carcinoma 1 (100%)
Liver (26) (27) (28) (36) (42) (39)
Cholangiocarcinoma 1 (4%)
Hepatocellular Adenoma 1 (3%)
Mesentery (8) (10) (8) (11) (8) (8)
Sarcoma 1 (13%) 2 (18%)
Sarcoma, Metastatic, Tissue NOS 1 (13%)
Oral Mucosa (4) (1)
Pharyngeal, Squamous Cell Papilloma 2 (50%)
Pancreas (1) (1) (1)
Tongue (1) (1)
Squamous Cell Papilloma 1 (100%) 1 (100%)
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CARDIOVASCULAR SYSTEM
Heart (1) (1) (1) (2) (2)
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ENDOCRINE SYSTEM
Adrenal Cortex (4) (1) (3) (1) (4)
Adenoma 1 (33%)
Adrenal Medulla (4) (1) (1)
Pheochromocytoma Malignant 1 (25%) 1 (100%)
Pheochromocytoma Benign 3 (75%) 1 (100%)
Islets, Pancreatic (1) (5) (1) (1)
Adenoma 2 (40%)
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NTP Experiment-Test: 88034-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OZONE/NNK Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:01:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE TRIOCT./ .1MG/KG TRIOCT./ .1M/KNNK 1M/K NNK 1 MG/KG
AIR NNK/AIR OZONE /OZONE /OZONE NNK/AIR
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Carcinoma 1 (100%) 3 (60%) 1 (100%) 1 (100%)
Pituitary Gland (34) (35) (29) (27) (30) (34)
Schwannoma Malignant, Metastatic, Tissue NOS 1 (3%)
Pars Distalis, Adenoma 32 (94%) 32 (91%) 28 (97%) 23 (85%) 25 (83%) 31 (91%)
Pars Distalis, Carcinoma 1 (3%)
Thyroid Gland (3) (2) (1) (1) (1)
Carcinoma 1 (33%) 1 (50%)
Bilateral, C-Cell, Adenoma 1 (50%)
C-Cell, Adenoma 1 (100%)
C-Cell, Carcinoma 1 (33%) 1 (100%)
Follicular Cell, Adenoma 1 (33%)
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GENERAL BODY SYSTEM
Peritoneum (32) (24) (30) (31) (26) (32)
Tissue NOS (1) (5) (1)
Sarcoma 1 (100%) 4 (80%)
Abdominal, Osteosarcoma 1 (100%)
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GENITAL SYSTEM
Epididymis (1) (1)
Preputial Gland (8) (6) (8) (2) (3) (9)
Adenoma 1 (13%) 1 (13%)
Carcinoma 2 (33%)
Seminal Vesicle (1)
Testes (20) (9) (24) (25) (19) (13)
Interstitial Cell, Adenoma 15 (75%) 9 (100%) 20 (83%) 23 (92%) 19 (100%) 12 (92%)
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HEMATOPOIETIC SYSTEM
Bone Marrow (1) (1)
Lymph Node (9) (7) (10) (10) (17) (26)
Lymph Node, Bronchial (38) (32) (23) (26) (30) (28)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (3%)
Squamous Cell Carcinoma, Metastatic, Lung 1 (3%)
Lymph Node, Mandibular (4) (8) (7) (7) (15) (14)
Lymph Node, Mesenteric (2) (8) (3) (11) (8) (9)
Lymph Node, Mediastinal (42) (37) (43) (43) (43) (45)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Squamous Cell Carcinoma, Metastatic, Lung 1 (2%)
Spleen (35) (32) (33) (37) (39) (39)
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NTP Experiment-Test: 88034-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OZONE/NNK Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:01:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE TRIOCT./ .1MG/KG TRIOCT./ .1M/KNNK 1M/K NNK 1 MG/KG
AIR NNK/AIR OZONE /OZONE /OZONE NNK/AIR
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Fibroma 1 (3%)
Sarcoma 1 (3%)
Thymus (1) (1) (3) (2) (3)
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INTEGUMENTARY SYSTEM
Mammary Gland (4) (5) (2) (4) (5)
Fibroadenoma 1 (25%) 1 (25%)
Skin (47) (47) (48) (48) (48) (47)
Basal Cell Adenoma 1 (2%)
Keratoacanthoma 2 (4%) 2 (4%) 4 (8%) 2 (4%) 2 (4%) 2 (4%)
Keratoacanthoma, Multiple 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%) 1 (2%) 2 (4%)
Trichoepithelioma 1 (2%)
Sebaceous Gland, Adenoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibroma 2 (4%) 4 (9%) 2 (4%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Melanoma Benign 1 (2%)
Subcutaneous Tissue, Skin, Site of
Application, Osteosarcoma 1 (2%)
Subcutaneous Tissue, Skin, Site of
Application, Sarcoma 3 (6%) 4 (9%) 5 (10%) 5 (10%) 1 (2%) 5 (11%)
Subcutaneous Tissue, Skin, Site of
Application, Sarcoma, Multiple 1 (2%)
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
Brain (2) (1)
Cranial Nerve, Schwannoma Malignant 1 (50%)
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RESPIRATORY SYSTEM
Lung (48) (48) (48) (48) (48) (48)
Alveolar/Bronchiolar Adenoma 3 (6%) 2 (4%) 1 (2%) 2 (4%) 14 (29%) 11 (23%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%) 9 (19%) 9 (19%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 9 (19%) 8 (17%)
Alveolar/Bronchiolar Carcinoma, Multiple 2 (4%)
Cholangiocarcinoma, Metastatic, Liver 1 (2%)
Sarcoma, Metastatic, Skin 1 (2%) 1 (2%)
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NTP Experiment-Test: 88034-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OZONE/NNK Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:01:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE TRIOCT./ .1MG/KG TRIOCT./ .1M/KNNK 1M/K NNK 1 MG/KG
AIR NNK/AIR OZONE /OZONE /OZONE NNK/AIR
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Squamous Cell Carcinoma 2 (4%) 1 (2%)
Mediastinum, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
Nose (47) (48) (48) (48) (46) (48)
Respiratory Epithelium, Adenoma 1 (2%)
Pleura (2)
Sarcoma, Metastatic, Tissue NOS 1 (50%)
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SPECIAL SENSES SYSTEM
Zymbal's Gland (3) (1)
Carcinoma 3 (100%) 1 (100%)
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URINARY SYSTEM
Kidney (27) (22) (15) (20) (25) (24)
Sarcoma, Metastatic, Tissue NOS 1 (4%)
Transitional Epithelium, Carcinoma 1 (4%)
Urinary Bladder (2) (2) (3) (1) (1)
Papilloma 1 (33%)
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SYSTEMIC LESIONS
Multiple Organs *(48) *(48) *(48) *(48) *(48) *(48)
Leukemia Mononuclear 28 (58%) 25 (52%) 25 (52%) 35 (73%) 40 (83%) 37 (77%)
Mesothelioma Malignant 2 (4%) 1 (2%) 1 (2%)
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* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 88034-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OZONE/NNK Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:01:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE TRIOCT./ .1MG/KG TRIOCT./ .1M/KNNK 1M/K NNK 1 MG/KG
AIR NNK/AIR OZONE /OZONE /OZONE NNK/AIR
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 48 48 45 47 47 48
Total Primary Neoplasms 105 95 96 100 134 124
Total Animals with Benign Neoplasms 41 40 39 37 37 42
Total Benign Neoplasms 63 58 58 53 75 71
Total Animals with Malignant Neoplasms 36 30 34 41 43 40
Total Malignant Neoplasms 42 37 38 47 59 53
Total Animals with Metastatic Neoplasms 2 3 3 1
Total Metastatic Neoplasm 2 3 6 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
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a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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