TDMS Study 88034-07 Pathology Tables
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
Facility: Battelle Northwest
Chemical CAS #: 10028-15-6
Lock Date: 02/17/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 5| 5| 6| 5| 6| 7| 6| 7| 5| 6| 6| 7| 6| 5| 6| 7| 6| 5| 4| 5|
DAY ON TEST | 4| 0| 0| 3| 3| 4| 8| 1| 6| 9| 3| 3| 3| 6| 0| 2| 3| 6| 5| 9| 0| 5| 5| 8| 6|
| 3| 0| 0| 6| 8| 0| 9| 1| 2| 8| 6| 3| 6| 4| 4| 0| 6| 9| 6| 7| 4| 5| 6| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
TRIOCT./ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
AIR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Intestine Large, Colon | + |
Mineralization | 3 |
__________________________________________________________________________|
Intestine Large, Rectum | + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 2 |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia, Focal | 4 |
Infiltration Cellular, Mixed Cell | 1 |
Necrosis | 3 |
Vacuolization Cytoplasmic, Focal | 2 |
Vacuolization Cytoplasmic | |
Bile Duct, Hyperplasia | 3 |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 3 3 3 |
__________________________________________________________________________|
Pancreas | + |
__________________________________________________________________________|
Stomach, Forestomach | + |
Mineralization | 3 |
__________________________________________________________________________|
Stomach, Glandular | + |
Mineralization | 3 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | 3 |
__________________________________________________________________________|
Heart | + |
Mineralization | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + |
__________________________________________________________________________|
Adrenal Medulla | + + |
Hemorrhage | 4 |
__________________________________________________________________________|
Islets, Pancreatic | + |
__________________________________________________________________________|
Parathyroid Gland | + |
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 5| 5| 6| 5| 6| 7| 6| 7| 5| 6| 6| 7| 6| 5| 6| 7| 6| 5| 4| 5|
DAY ON TEST | 4| 0| 0| 3| 3| 4| 8| 1| 6| 9| 3| 3| 3| 6| 0| 2| 3| 6| 5| 9| 0| 5| 5| 8| 6|
| 3| 0| 0| 6| 8| 0| 9| 1| 2| 8| 6| 3| 6| 4| 4| 0| 6| 9| 6| 7| 4| 5| 6| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
TRIOCT./ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
AIR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Epididymis | + |
Granuloma Sperm | 3 |
__________________________________________________________________________|
Preputial Gland | + + + |
Inflammation, Chronic Active | 2 3 |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + |
Atrophy | 4 3 |
Interstitial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Lymph Node | + + + + |
Infiltration Cellular, Plasma Cell | |
Iliac, Infiltration Cellular, Plasma | |
Cell | 2 |
Pancreatic, Inflammation, | |
Granulomatous | 2 |
Renal, Hemorrhage | |
Renal, Infiltration Cellular, Plasma | |
Cell | 3 2 |
Renal, Inflammation, Granulomatous | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + M M + M M + + + + + + + + + M + + + + M|
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + M + + M|
Hemorrhage | 4 |
Infiltration Cellular, Plasma Cell | 2 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X |
Congestion | 1 |
Fibrosis | 2 2 2 3 2 2|
Hematopoietic Cell Proliferation | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + |
Galactocele | 3 |
Hyperplasia | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3|
Subcutaneous Tissue, Inflammation, | |
Chronic | |
Subcutaneous Tissue, Skin, Site of | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 5| 5| 6| 5| 6| 7| 6| 7| 5| 6| 6| 7| 6| 5| 6| 7| 6| 5| 4| 5|
DAY ON TEST | 4| 0| 0| 3| 3| 4| 8| 1| 6| 9| 3| 3| 3| 6| 0| 2| 3| 6| 5| 9| 0| 5| 5| 8| 6|
| 3| 0| 0| 6| 8| 0| 9| 1| 2| 8| 6| 3| 6| 4| 4| 0| 6| 9| 6| 7| 4| 5| 6| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
TRIOCT./ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
AIR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Application, Inflammation, | |
Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X|
Inflammation, Suppurative | 1 |
Metaplasia, Squamous | 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis, Focal | 2 3 |
Hemorrhage | 2 1 1 |
Mineralization | 4 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 |
Interstitium, Inflammation, Chronic, | |
Diffuse | 3 2 |
Perivascular, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
Goblet Cell, Lateral Wall, | |
Hyperplasia | 1 1 1 |
Lateral Wall, Hyperplasia | 2 1 1 1 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 1 1 1 1 1 1|
Olfactory Epithelium, Metaplasia | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 4 |
Hemorrhage | 4 |
Ciliary Body, Retina, Degeneration | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + +|
Cyst | |
Hydronephrosis | |
Nephropathy | 4 3 2 4 3 3 3 3 4 4 4 3 3|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 6| 4| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 5| 6| 3| 7| 7| 6| 5| 6| 6| 6| | |
DAY ON TEST | 6| 6| 7| 0| 3| 8| 6| 3| 0| 1| 8| 4| 3| 1| 1| 2| 2| 3| 9| 7| 2| 7| 1| | |
| 4| 6| 2| 6| 6| 1| 3| 6| 9| 7| 5| 1| 6| 5| 1| 7| 4| 6| 2| 6| 0| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
TRIOCT./ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 1 |
Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + | 26 |
Degeneration, Cystic | 2 2 2 | 5 2.0|
Hepatodiaphragmatic Nodule | X X | 4 |
Hyperplasia, Focal | | 1 4.0|
Infiltration Cellular, Mixed Cell | | 1 1.0|
Necrosis | | 1 3.0|
Vacuolization Cytoplasmic, Focal | | 1 2.0|
Vacuolization Cytoplasmic | 2 | 1 2.0|
Bile Duct, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 8 |
Fat, Necrosis | 3 2 3 3 | 7 2.9|
__________________________________________________________________________|____________|
Pancreas | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 1 |
Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 1 |
Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 2 |
Aorta, Mineralization | 3 | 2 3.0|
__________________________________________________________________________|____________|
Heart | | 1 |
Mineralization | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + | 4 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + | 4 |
Hemorrhage | | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + | 2 |
Hyperplasia | 4 | 2 3.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + M + + + + + + + + | 34 |
Pars Distalis, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 5
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 6| 4| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 5| 6| 3| 7| 7| 6| 5| 6| 6| 6| | |
DAY ON TEST | 6| 6| 7| 0| 3| 8| 6| 3| 0| 1| 8| 4| 3| 1| 1| 2| 2| 3| 9| 7| 2| 7| 1| | |
| 4| 6| 2| 6| 6| 1| 3| 6| 9| 7| 5| 1| 6| 5| 1| 7| 4| 6| 2| 6| 0| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
TRIOCT./ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + + + + + + + + + + + + + + + | 32 |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 30 1.0|
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 1 |
Granuloma Sperm | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 8 |
Inflammation, Chronic Active | 2 3 3 2 | 6 2.5|
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + | 20 |
Atrophy | 3 3 3 3 | 6 3.2|
Interstitial Cell, Hyperplasia | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 9 |
Infiltration Cellular, Plasma Cell | 3 | 1 3.0|
Iliac, Infiltration Cellular, Plasma | | |
Cell | | 1 2.0|
Pancreatic, Inflammation, | | |
Granulomatous | | 1 2.0|
Renal, Hemorrhage | 2 | 1 2.0|
Renal, Infiltration Cellular, Plasma | | |
Cell | 2 3 | 4 2.5|
Renal, Inflammation, Granulomatous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + M + + + + + M + + M + M + + + | 38 |
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | 2 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + I + + + I + + + + + + + + M + + + + M + | 42 |
Hemorrhage | 2 | 2 3.0|
Infiltration Cellular, Plasma Cell | 2 | 2 2.0|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + | 35 |
Accessory Spleen | | 1 |
Congestion | 2 | 2 1.5|
Fibrosis | 2 2 2 2 2 2 | 12 2.1|
Hematopoietic Cell Proliferation | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 6| 4| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 5| 6| 3| 7| 7| 6| 5| 6| 6| 6| | |
DAY ON TEST | 6| 6| 7| 0| 3| 8| 6| 3| 0| 1| 8| 4| 3| 1| 1| 2| 2| 3| 9| 7| 2| 7| 1| | |
| 4| 6| 2| 6| 6| 1| 3| 6| 9| 7| 5| 1| 6| 5| 1| 7| 4| 6| 2| 6| 0| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
TRIOCT./ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + | 4 |
Galactocele | 3 | 2 3.0|
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + | 47 |
Inflammation, Chronic | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | 1 | 1 1.0|
Subcutaneous Tissue, Skin, Site of | | |
Application, Inflammation, | | |
Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 46 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Foreign Body | X X | 3 |
Inflammation, Suppurative | | 1 1.0|
Metaplasia, Squamous | | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Congestion | 2 2 | 2 2.0|
Fibrosis, Focal | | 2 2.5|
Hemorrhage | | 3 1.3|
Mineralization | 3 1 | 4 2.3|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
Interstitium, Inflammation, Chronic, | | |
Diffuse | 2 | 3 2.3|
Perivascular, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + M + | 47 |
Inflammation, Suppurative | | 1 3.0|
Goblet Cell, Lateral Wall, | | |
Hyperplasia | | 3 1.0|
Lateral Wall, Hyperplasia | 1 | 5 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 6| 4| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 5| 6| 3| 7| 7| 6| 5| 6| 6| 6| | |
DAY ON TEST | 6| 6| 7| 0| 3| 8| 6| 3| 0| 1| 8| 4| 3| 1| 1| 2| 2| 3| 9| 7| 2| 7| 1| | |
| 4| 6| 2| 6| 6| 1| 3| 6| 9| 7| 5| 1| 6| 5| 1| 7| 4| 6| 2| 6| 0| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
TRIOCT./ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1 2 1 2 2 1 | 47 1.1|
Olfactory Epithelium, Metaplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 3 |
Cataract | 2 4 | 3 3.3|
Hemorrhage | | 1 4.0|
Ciliary Body, Retina, Degeneration | 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + | 27 |
Cyst | 3 | 1 3.0|
Hydronephrosis | 3 | 1 3.0|
Nephropathy | 4 4 4 3 2 4 4 3 3 4 3 3 3 3 | 27 3.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 4| 4| 6| 7| 5| 4| 5| 7| 6| 6| 4| 7| 6| 6| 7| 5| 5| 5| 6| 6| 6| 6| 5| 5| 6|
DAY ON TEST | 1| 7| 1| 3| 8| 6| 4| 1| 8| 2| 6| 3| 6| 4| 0| 8| 0| 1| 3| 5| 2| 3| 8| 5| 8|
| 7| 8| 2| 6| 2| 6| 4| 0| 3| 0| 0| 6| 2| 1| 4| 9| 1| 8| 3| 5| 5| 5| 9| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.1MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
NNK/AIR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Intestine Large, Cecum | + |
__________________________________________________________________________|
Intestine Small, Ileum | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + +|
Angiectasis | |
Degeneration, Cystic | 2 |
Hepatodiaphragmatic Nodule | X X|
Hyperplasia, Focal | 4 |
Vacuolization Cytoplasmic, Focal | |
Vacuolization Cytoplasmic | 3 |
Bile Duct, Hyperplasia | 3 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + + + |
Fat, Necrosis | 3 3 3 3 3 3 |
__________________________________________________________________________|
Oral Mucosa | + + |
Pharyngeal, Hyperplasia, Squamous | 3 |
__________________________________________________________________________|
Stomach, Glandular | |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + |
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | |
__________________________________________________________________________|
Islets, Pancreatic | + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + + + + + + + + + + + + + |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Penis | + + |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + |
Inflammation, Chronic Active | 4 2 |
__________________________________________________________________________|
Prostate | + |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Testes | + + + + + |
Atrophy | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 4| 4| 6| 7| 5| 4| 5| 7| 6| 6| 4| 7| 6| 6| 7| 5| 5| 5| 6| 6| 6| 6| 5| 5| 6|
DAY ON TEST | 1| 7| 1| 3| 8| 6| 4| 1| 8| 2| 6| 3| 6| 4| 0| 8| 0| 1| 3| 5| 2| 3| 8| 5| 8|
| 7| 8| 2| 6| 2| 6| 4| 0| 3| 0| 0| 6| 2| 1| 4| 9| 1| 8| 3| 5| 5| 5| 9| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.1MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
NNK/AIR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | |
__________________________________________________________________________|
Lymph Node | + + + + |
Renal, Infiltration Cellular, Plasma | |
Cell | 2 |
Renal, Inflammation, Granulomatous | 2 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + M M M + M M M + + M + + + + + + + M + + M + + +|
Hemorrhage | 2 |
Necrosis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + |
Inflammation, Granulomatous | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + + M + + + + + + + + + + + + M M + + + + +|
Hemorrhage | |
Infiltration Cellular, Plasma Cell | |
Necrosis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + |
Fibrosis | 2 3 3 2 3 2 |
Hematopoietic Cell Proliferation | |
Hemorrhage | 3 4 |
Necrosis | 4 |
__________________________________________________________________________|
Thymus | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + |
Galactocele | 3 3 4 |
Hyperplasia | |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Inflammation, Chronic | 3 |
Ulcer | 3 3 |
Prepuce, Inflammation, Suppurative | |
Subcutaneous Tissue, Skin, Site of | |
Application, Inflammation, | |
Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 4| 4| 6| 7| 5| 4| 5| 7| 6| 6| 4| 7| 6| 6| 7| 5| 5| 5| 6| 6| 6| 6| 5| 5| 6|
DAY ON TEST | 1| 7| 1| 3| 8| 6| 4| 1| 8| 2| 6| 3| 6| 4| 0| 8| 0| 1| 3| 5| 2| 3| 8| 5| 8|
| 7| 8| 2| 6| 2| 6| 4| 0| 3| 0| 0| 6| 2| 1| 4| 9| 1| 8| 3| 5| 5| 5| 9| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.1MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
NNK/AIR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Foreign Body | X X |
Inflammation, Suppurative | 1 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis, Focal | 2 |
Hemorrhage | 3 2 |
Alveolar Epithelium, Hyperplasia, | |
Atypical | 3 2 2 2 1 1 |
Alveolus, Infiltration Cellular, | |
Focal, Histiocyte | 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
Interstitium, Inflammation, Chronic, | |
Diffuse | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Inflammation, Suppurative | 1 |
Lateral Wall, Hyperplasia | 1 2 2 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 2 2 1|
Olfactory Epithelium, Metaplasia | 1 1 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + |
Nephropathy | 4 3 3 3 3 2 3 2 4 4 |
__________________________________________________________________________|
Urinary Bladder | + + |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 6| 4| 7| 6| 7| 5| 6| 7| 6| 6| 7| 6| 5| 6| 6| 6| 5| 7| 5| | |
DAY ON TEST | 7| 3| 1| 5| 9| 4| 0| 1| 1| 0| 6| 3| 1| 3| 3| 7| 2| 3| 7| 4| 5| 3| 5| | |
| 9| 6| 5| 5| 7| 4| 4| 7| 6| 1| 3| 6| 3| 9| 6| 3| 9| 5| 1| 1| 1| 6| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
.1MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
NNK/AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + | 27 |
Angiectasis | 2 | 1 2.0|
Degeneration, Cystic | 2 2 | 3 2.0|
Hepatodiaphragmatic Nodule | | 2 |
Hyperplasia, Focal | | 1 4.0|
Vacuolization Cytoplasmic, Focal | 2 | 1 2.0|
Vacuolization Cytoplasmic | 2 2 3 | 4 2.5|
Bile Duct, Hyperplasia | 2 | 2 2.5|
Centrilobular, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 10 |
Fat, Necrosis | 2 3 3 | 9 2.9|
__________________________________________________________________________|____________|
Oral Mucosa | + + | 4 |
Pharyngeal, Hyperplasia, Squamous | 3 | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + | 1 |
__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 1 |
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 5 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + | 35 |
Pars Distalis, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Thyroid Gland | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + + + + + + + + + + + | 24 |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 | 24 1.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Penis | + + | 4 |
Inflammation, Chronic Active | 2 | 2 2.5|
__________________________________________________________________________|____________|
Preputial Gland | + + | 6 |
Inflammation, Chronic Active | | 2 3.0|
__________________________________________________________________________|____________|
Prostate | + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 6| 4| 7| 6| 7| 5| 6| 7| 6| 6| 7| 6| 5| 6| 6| 6| 5| 7| 5| | |
DAY ON TEST | 7| 3| 1| 5| 9| 4| 0| 1| 1| 0| 6| 3| 1| 3| 3| 7| 2| 3| 7| 4| 5| 3| 5| | |
| 9| 6| 5| 5| 7| 4| 4| 7| 6| 1| 3| 6| 3| 9| 6| 3| 9| 5| 1| 1| 1| 6| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
.1MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
NNK/AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 4 | 2 3.5|
__________________________________________________________________________|____________|
Testes | + + + + | 9 |
Atrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + | 7 |
Renal, Infiltration Cellular, Plasma | | |
Cell | | 1 2.0|
Renal, Inflammation, Granulomatous | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + M M + + + M + + + M + M M + + + + + | 32 |
Hemorrhage | | 1 2.0|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + | 8 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 8 |
Inflammation, Granulomatous | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + M I M + + M + M + + + + + + + M I | 37 |
Hemorrhage | 3 | 1 3.0|
Infiltration Cellular, Plasma Cell | 2 | 1 2.0|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 32 |
Fibrosis | 2 2 2 2 2 3 3 3 | 14 2.4|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hemorrhage | | 2 3.5|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + | 5 |
Galactocele | | 3 3.3|
Hyperplasia | 3 3 | 2 3.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Hyperkeratosis | 3 3 | 2 3.0|
Inflammation, Chronic | | 1 3.0|
Ulcer | | 2 3.0|
Prepuce, Inflammation, Suppurative | 3 | 1 3.0|
Subcutaneous Tissue, Skin, Site of | | |
Application, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 6| 4| 7| 6| 7| 5| 6| 7| 6| 6| 7| 6| 5| 6| 6| 6| 5| 7| 5| | |
DAY ON TEST | 7| 3| 1| 5| 9| 4| 0| 1| 1| 0| 6| 3| 1| 3| 3| 7| 2| 3| 7| 4| 5| 3| 5| | |
| 9| 6| 5| 5| 7| 4| 4| 7| 6| 1| 3| 6| 3| 9| 6| 3| 9| 5| 1| 1| 1| 6| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
.1MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
NNK/AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 47 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Foreign Body | | 2 |
Inflammation, Suppurative | 1 1 | 4 1.3|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Congestion | 1 1 | 2 1.0|
Fibrosis, Focal | | 1 2.0|
Hemorrhage | | 2 2.5|
Alveolar Epithelium, Hyperplasia, | | |
Atypical | 1 2 2 2 | 10 1.8|
Alveolus, Infiltration Cellular, | | |
Focal, Histiocyte | | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
Interstitium, Inflammation, Chronic, | | |
Diffuse | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation, Chronic | | 1 1.0|
Inflammation, Suppurative | | 1 1.0|
Lateral Wall, Hyperplasia | 1 | 4 1.5|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 1 1 1 1 1 2 1 1 1 1 2 1 1 1 2 2 1 2 2 1 1 | 48 1.2|
Olfactory Epithelium, Metaplasia | | 4 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + | 22 |
Nephropathy | 3 3 3 3 4 2 4 3 3 3 3 4 | 22 3.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 6| 4| 7| 6| 7| 5| 6| 7| 6| 6| 7| 6| 5| 6| 6| 6| 5| 7| 5| | |
DAY ON TEST | 7| 3| 1| 5| 9| 4| 0| 1| 1| 0| 6| 3| 1| 3| 3| 7| 2| 3| 7| 4| 5| 3| 5| | |
| 9| 6| 5| 5| 7| 4| 4| 7| 6| 1| 3| 6| 3| 9| 6| 3| 9| 5| 1| 1| 1| 6| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
.1MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
NNK/AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | | 2 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 5| 5| 6| 6| 7| 6| 6| 5| 7| 7| 5| 6| 6| 6| 4| 5| 6| 6| 6| 5| 6| 6| 7| 5| 6|
DAY ON TEST | 6| 5| 0| 7| 3| 8| 6| 2| 3| 1| 2| 1| 3| 6| 2| 9| 0| 8| 8| 7| 0| 9| 3| 4| 0|
| 2| 1| 3| 8| 6| 3| 3| 8| 6| 5| 9| 7| 9| 1| 9| 0| 3| 3| 7| 9| 4| 5| 6| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
NNK/AIR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Intestine Large, Colon | + |
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | 2 |
__________________________________________________________________________|
Intestine Large, Cecum | |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Jejunum | + |
__________________________________________________________________________|
Intestine Small, Ileum | + |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 3 2 2 |
Hepatodiaphragmatic Nodule | |
Hyperplasia, Focal | 4 3 4|
Necrosis, Focal | 2 2 |
Vacuolization Cytoplasmic | 2 2 |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 1 3 3 3 |
__________________________________________________________________________|
Pancreas | |
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Stomach, Forestomach | +|
__________________________________________________________________________|
Stomach, Glandular | + +|
Necrosis | 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | |
__________________________________________________________________________|
Islets, Pancreatic | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + M + + + + + +|
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Penis | + + + +|
Inflammation, Chronic Active | 2 2|
__________________________________________________________________________|
Preputial Gland | + + + + + + |
Inflammation, Chronic Active | 2 4 2 2 |
__________________________________________________________________________|
Seminal Vesicle | |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 5| 5| 6| 6| 7| 6| 6| 5| 7| 7| 5| 6| 6| 6| 4| 5| 6| 6| 6| 5| 6| 6| 7| 5| 6|
DAY ON TEST | 6| 5| 0| 7| 3| 8| 6| 2| 3| 1| 2| 1| 3| 6| 2| 9| 0| 8| 8| 7| 0| 9| 3| 4| 0|
| 2| 1| 3| 8| 6| 3| 3| 8| 6| 5| 9| 7| 9| 1| 9| 0| 3| 3| 7| 9| 4| 5| 6| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
NNK/AIR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Testes | + + + + + + +|
Atrophy | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + +|
Pancreatic, Inflammation, | |
Granulomatous | 2 |
Renal, Hemorrhage | 3 3|
Renal, Infiltration Cellular, Plasma | |
Cell | 1 2 2 |
Renal, Inflammation, Granulomatous | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M M M M M M + + M + I + + + + M M M M M +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + +|
Infiltration Cellular, Plasma Cell | 3 2 3|
Necrosis | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + + + + + + + + + + + + + + M + + + + + + +|
Fibrosis | 3 |
Hemorrhage | 3 2 |
Infiltration Cellular, Plasma Cell | 3 |
Necrosis | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X X |
Atrophy | 3 |
Fibrosis | 3 3 2 2 2|
Hematopoietic Cell Proliferation | 2 |
Necrosis | 4 |
__________________________________________________________________________|
Thymus | + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + |
Galactocele | 2 3 3 |
Hyperplasia | |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 3 |
Inflammation, Chronic | 2 3 |
Inflammation, Suppurative | 3 |
Ulcer | 2 |
Prepuce, Inflammation, Suppurative | 2 |
Subcutaneous Tissue, Skin, Site of | |
Application, Inflammation, | |
Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 5| 5| 6| 6| 7| 6| 6| 5| 7| 7| 5| 6| 6| 6| 4| 5| 6| 6| 6| 5| 6| 6| 7| 5| 6|
DAY ON TEST | 6| 5| 0| 7| 3| 8| 6| 2| 3| 1| 2| 1| 3| 6| 2| 9| 0| 8| 8| 7| 0| 9| 3| 4| 0|
| 2| 1| 3| 8| 6| 3| 3| 8| 6| 5| 9| 7| 9| 1| 9| 0| 3| 3| 7| 9| 4| 5| 6| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
NNK/AIR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Fibrosis, Focal | |
Hemorrhage | 2 |
Alveolar Epithelium, Hyperplasia, | |
Atypical | 1 1 2 4 3 2 1 2 3 2 2 3 2 3 2 3 2 2 2 2 2 1|
Alveolus, Infiltration Cellular, | |
Focal, Histiocyte | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 3 3 2 |
Serosa, Fibrosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 3 3 1 |
Goblet Cell, Lateral Wall, | |
Hyperplasia | 2 1 |
Lateral Wall, Hyperplasia | 1 2 3 2 |
Nasopharyngeal Duct, Infiltration | |
Cellular, Mixed Cell | |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 2 1 1 1 1 1 1|
Olfactory Epithelium, Metaplasia | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + +|
Infarct | 3|
Nephropathy | 3 2 3 3 4 4 3 3 3 2 4 4 3|
__________________________________________________________________________|
Ureter | + |
__________________________________________________________________________|
Urinary Bladder | |
Hemorrhage | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 7| 4| 5| 4| 7| 5| 5| 4| 6| 4| 6| 6| 6| 5| 6| 5| 5| 6| | |
DAY ON TEST | 8| 4| 0| 0| 0| 1| 8| 4| 5| 3| 9| 3| 8| 9| 8| 7| 8| 0| 8| 6| 5| 8| 4| | |
| 3| 5| 4| 3| 5| 2| 6| 0| 0| 6| 0| 3| 9| 5| 8| 7| 3| 5| 3| 9| 0| 3| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
NNK/AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 1 |
Lymphoid Tissue, Hyperplasia, | | |
Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A | 1 |
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 1 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + | 39 |
Degeneration, Cystic | 3 2 3 | 7 2.4|
Hepatodiaphragmatic Nodule | X | 1 |
Hyperplasia, Focal | 4 | 4 3.8|
Necrosis, Focal | 3 | 3 2.3|
Vacuolization Cytoplasmic | | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 8 |
Fat, Necrosis | 2 2 | 6 2.3|
__________________________________________________________________________|____________|
Pancreas | + | 1 |
Artery, Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + | 3 |
Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 4 |
Vacuolization Cytoplasmic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + | 34 |
Pars Distalis, Hyperplasia | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + + + + + + + + + + + + + + + | 32 |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 32 1.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 7| 4| 5| 4| 7| 5| 5| 4| 6| 4| 6| 6| 6| 5| 6| 5| 5| 6| | |
DAY ON TEST | 8| 4| 0| 0| 0| 1| 8| 4| 5| 3| 9| 3| 8| 9| 8| 7| 8| 0| 8| 6| 5| 8| 4| | |
| 3| 5| 4| 3| 5| 2| 6| 0| 0| 6| 0| 3| 9| 5| 8| 7| 3| 5| 3| 9| 0| 3| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
NNK/AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Penis | + | 5 |
Inflammation, Chronic Active | | 2 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + | 9 |
Inflammation, Chronic Active | 4 2 2 | 7 2.6|
__________________________________________________________________________|____________|
Seminal Vesicle | + | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + | 13 |
Atrophy | 3 4 | 3 3.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + | 26 |
Pancreatic, Inflammation, | | |
Granulomatous | | 1 2.0|
Renal, Hemorrhage | 3 | 3 3.0|
Renal, Infiltration Cellular, Plasma | | |
Cell | 3 2 | 5 2.0|
Renal, Inflammation, Granulomatous | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + + + + M + + M + M + M + + + + + M M | 28 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 14 |
Infiltration Cellular, Plasma Cell | | 3 2.7|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + M + | 45 |
Fibrosis | | 1 3.0|
Hemorrhage | | 2 2.5|
Infiltration Cellular, Plasma Cell | | 1 3.0|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + | 39 |
Accessory Spleen | X X | 4 |
Atrophy | | 1 3.0|
Fibrosis | 2 3 2 2 3 | 10 2.4|
Hematopoietic Cell Proliferation | | 1 2.0|
Necrosis | 3 4 | 3 3.7|
__________________________________________________________________________|____________|
Thymus | + | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + | 5 |
Galactocele | 4 | 4 3.0|
Hyperplasia | 2 | 1 2.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 7| 4| 5| 4| 7| 5| 5| 4| 6| 4| 6| 6| 6| 5| 6| 5| 5| 6| | |
DAY ON TEST | 8| 4| 0| 0| 0| 1| 8| 4| 5| 3| 9| 3| 8| 9| 8| 7| 8| 0| 8| 6| 5| 8| 4| | |
| 3| 5| 4| 3| 5| 2| 6| 0| 0| 6| 0| 3| 9| 5| 8| 7| 3| 5| 3| 9| 0| 3| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
NNK/AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + | 47 |
Hyperkeratosis | 3 | 3 2.7|
Inflammation, Chronic | | 2 2.5|
Inflammation, Suppurative | | 1 3.0|
Ulcer | | 1 2.0|
Prepuce, Inflammation, Suppurative | | 1 2.0|
Subcutaneous Tissue, Skin, Site of | | |
Application, Inflammation, | | |
Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 48 1.1|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 1 |
Hemorrhage | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Congestion | 1 1 | 3 1.0|
Fibrosis, Focal | 3 | 1 3.0|
Hemorrhage | 2 4 2 2 | 5 2.4|
Alveolar Epithelium, Hyperplasia, | | |
Atypical | 2 2 2 2 1 1 2 2 2 2 2 2 3 2 2 3 3 | 39 2.1|
Alveolus, Infiltration Cellular, | | |
Focal, Histiocyte | 3 | 1 3.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 2 2 3 | 8 2.3|
Serosa, Fibrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation, Suppurative | 2 | 5 2.4|
Goblet Cell, Lateral Wall, | | |
Hyperplasia | 1 | 3 1.3|
Lateral Wall, Hyperplasia | 1 | 5 1.8|
Nasopharyngeal Duct, Infiltration | | |
Cellular, Mixed Cell | 2 | 1 2.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 1 1 1 2 1 2 1 1 2 1 1 1 1 2 1 3 2 1 2 1 | 45 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 7| 4| 5| 4| 7| 5| 5| 4| 6| 4| 6| 6| 6| 5| 6| 5| 5| 6| | |
DAY ON TEST | 8| 4| 0| 0| 0| 1| 8| 4| 5| 3| 9| 3| 8| 9| 8| 7| 8| 0| 8| 6| 5| 8| 4| | |
| 3| 5| 4| 3| 5| 2| 6| 0| 0| 6| 0| 3| 9| 5| 8| 7| 3| 5| 3| 9| 0| 3| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
NNK/AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Olfactory Epithelium, Metaplasia | 2 | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cataract | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + | 24 |
Infarct | 3 | 2 3.0|
Nephropathy | 3 3 3 3 3 4 4 3 3 | 22 3.2|
__________________________________________________________________________|____________|
Ureter | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + | 1 |
Hemorrhage | 3 | 1 3.0|
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 7| 5| 6| 4| 4| 6| 6| 5| 6| 6| 3| 3| 1| 7| 6| 5| 7| 7| 5| 5| 5| 6| 7| 6| 6|
DAY ON TEST | 2| 5| 0| 5| 4| 3| 6| 0| 7| 7| 8| 3| 9| 1| 2| 8| 3| 0| 2| 9| 1| 4| 0| 1| 1|
| 5| 6| 3| 8| 0| 6| 9| 2| 8| 3| 9| 3| 2| 2| 4| 9| 6| 9| 3| 2| 5| 5| 4| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
TRIOCT./ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
OZONE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Intestine Large, Colon | |
Mineralization | |
__________________________________________________________________________|
Intestine Large, Rectum | |
Mineralization | |
__________________________________________________________________________|
Intestine Large, Cecum | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + +|
Angiectasis | 2|
Degeneration, Cystic | 2 2 |
Hepatodiaphragmatic Nodule | X |
Hyperplasia, Focal | 3 |
Necrosis, Focal | |
Vacuolization Cytoplasmic | 2 2 2 |
Bile Duct, Hyperplasia | 3 |
__________________________________________________________________________|
Mesentery | + + + + +|
Fat, Necrosis | 3 2 3 |
__________________________________________________________________________|
Oral Mucosa | + |
Pharyngeal, Foreign Body | X |
__________________________________________________________________________|
Pancreas | + |
__________________________________________________________________________|
Stomach, Forestomach | + |
Mineralization | 3 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + |
Mineralization | 3 |
Necrosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Inflammation, Chronic | 2 |
Mineralization | 3 |
__________________________________________________________________________|
Heart | |
Cardiomyopathy | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + +|
Angiectasis | 3|
__________________________________________________________________________|
Islets, Pancreatic | + |
__________________________________________________________________________|
Parathyroid Gland | |
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + |
Follicular Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 7| 5| 6| 4| 4| 6| 6| 5| 6| 6| 3| 3| 1| 7| 6| 5| 7| 7| 5| 5| 5| 6| 7| 6| 6|
DAY ON TEST | 2| 5| 0| 5| 4| 3| 6| 0| 7| 7| 8| 3| 9| 1| 2| 8| 3| 0| 2| 9| 1| 4| 0| 1| 1|
| 5| 6| 3| 8| 0| 6| 9| 2| 8| 3| 9| 3| 2| 2| 4| 9| 6| 9| 3| 2| 5| 5| 4| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
TRIOCT./ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
OZONE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Tissue NOS | + + + + + |
Mediastinum, Inflammation, Chronic | |
Active, Diffuse | 4 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Penis | +|
Calculus Gross Observation | |
Calculus Micro Observation Only | |
__________________________________________________________________________|
Preputial Gland | + + + + + |
Inflammation, Chronic Active | 2 4 3 |
__________________________________________________________________________|
Prostate | + |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + +|
Atrophy | 2 |
Necrosis | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Lymph Node | + + + |
Hyperplasia, Lymphoid | 2 |
Pigmentation | 3 |
Renal, Hemorrhage | |
Renal, Inflammation, Granulomatous | |
__________________________________________________________________________|
Lymph Node, Bronchial | M M M + + + + M + + + + M + M + + M + M + M M M +|
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + |
Infiltration Cellular, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + I + + + + + + + + M + + + + M + M + + + + + + +|
Hemorrhage | 3 3 3|
Infiltration Cellular, Plasma Cell | 2 1 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + +|
Congestion | 2 |
Fibrosis | 2 1 |
Hematopoietic Cell Proliferation | 3|
Necrosis | 4 |
__________________________________________________________________________|
Thymus | + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + |
Galactocele | 3 |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 7| 5| 6| 4| 4| 6| 6| 5| 6| 6| 3| 3| 1| 7| 6| 5| 7| 7| 5| 5| 5| 6| 7| 6| 6|
DAY ON TEST | 2| 5| 0| 5| 4| 3| 6| 0| 7| 7| 8| 3| 9| 1| 2| 8| 3| 0| 2| 9| 1| 4| 0| 1| 1|
| 5| 6| 3| 8| 0| 6| 9| 2| 8| 3| 9| 3| 2| 2| 4| 9| 6| 9| 3| 2| 5| 5| 4| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
TRIOCT./ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
OZONE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Prepuce, Inflammation, Suppurative | |
Subcutaneous Tissue, Skin, Site of | |
Application, Inflammation, | |
Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X |
Inflammation, Suppurative | 2 |
Mineralization | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hemorrhage | 1 |
Mineralization | 3 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolar Epithelium, Metaplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 2 1 |
Bronchus, Inflammation, Suppurative | 3 |
Interstitium, Fibrosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Interstitium, Inflammation, Chronic, | |
Diffuse | 1 |
Serosa, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 |
Goblet Cell, Lateral Wall, | |
Hyperplasia | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 |
Lateral Wall, Hyperplasia | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 3 2 2 2 3 2 2 2|
Olfactory Epithelium, Metaplasia | |
Turbinate, Necrosis | |
__________________________________________________________________________|
Pleura | + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 7| 5| 6| 4| 4| 6| 6| 5| 6| 6| 3| 3| 1| 7| 6| 5| 7| 7| 5| 5| 5| 6| 7| 6| 6|
DAY ON TEST | 2| 5| 0| 5| 4| 3| 6| 0| 7| 7| 8| 3| 9| 1| 2| 8| 3| 0| 2| 9| 1| 4| 0| 1| 1|
| 5| 6| 3| 8| 0| 6| 9| 2| 8| 3| 9| 3| 2| 2| 4| 9| 6| 9| 3| 2| 5| 5| 4| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
TRIOCT./ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
OZONE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
Ciliary Body, Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + |
Cyst | |
Nephropathy | 3 4 3 3 3 3 |
__________________________________________________________________________|
Urinary Bladder | |
Calculus Gross Observation | |
Calculus Micro Observation Only | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 6| 6| 7| 7| 5| 5| 6| 6| 6| 6| 2| 6| 6| 7| 5| 7| 5| 6| 5| 4| | |
DAY ON TEST | 3| 9| 0| 3| 9| 3| 0| 8| 5| 6| 5| 3| 3| 5| 3| 1| 2| 3| 1| 2| 3| 6| 8| | |
| 6| 0| 5| 5| 4| 6| 5| 0| 0| 1| 9| 4| 4| 3| 1| 4| 2| 7| 8| 9| 5| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
TRIOCT./ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
OZONE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 1 |
Mineralization | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 1 |
Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | A | |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + | 28 |
Angiectasis | 2 1 | 3 1.7|
Degeneration, Cystic | 2 1 | 4 1.8|
Hepatodiaphragmatic Nodule | | 1 |
Hyperplasia, Focal | | 1 3.0|
Necrosis, Focal | 1 | 1 1.0|
Vacuolization Cytoplasmic | 2 | 4 2.0|
Bile Duct, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 8 |
Fat, Necrosis | 2 3 | 5 2.6|
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
Pharyngeal, Foreign Body | | 1 |
__________________________________________________________________________|____________|
Pancreas | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 2 |
Mineralization | | 1 3.0|
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 3 |
Mineralization | 3 | 2 3.0|
Necrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Inflammation, Chronic | | 1 2.0|
Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + | 1 |
Cardiomyopathy | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | | 3 |
Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + | 1 |
Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + | 29 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 6| 6| 7| 7| 5| 5| 6| 6| 6| 6| 2| 6| 6| 7| 5| 7| 5| 6| 5| 4| | |
DAY ON TEST | 3| 9| 0| 3| 9| 3| 0| 8| 5| 6| 5| 3| 3| 5| 3| 1| 2| 3| 1| 2| 3| 6| 8| | |
| 6| 0| 5| 5| 4| 6| 5| 0| 0| 1| 9| 4| 4| 3| 1| 4| 2| 7| 8| 9| 5| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
TRIOCT./ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
OZONE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | | 1 |
Follicular Cell, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + + + + + + + + + + + + + + + + | 30 |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 30 1.0|
__________________________________________________________________________|____________|
Tissue NOS | | 5 |
Mediastinum, Inflammation, Chronic | | |
Active, Diffuse | | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Penis | + + | 3 |
Calculus Gross Observation | X | 1 |
Calculus Micro Observation Only | X | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + | 8 |
Inflammation, Chronic Active | 2 3 | 5 2.8|
__________________________________________________________________________|____________|
Prostate | | 1 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + | 24 |
Atrophy | | 1 2.0|
Necrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + | 10 |
Hyperplasia, Lymphoid | | 1 2.0|
Pigmentation | | 1 3.0|
Renal, Hemorrhage | 2 | 1 2.0|
Renal, Inflammation, Granulomatous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M M + + M M M M + + + M + M M M M M + M + + | 23 |
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + | 7 |
Infiltration Cellular, Plasma Cell | 2 2 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 3 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + M + + + + + + + | 43 |
Hemorrhage | | 3 3.0|
Infiltration Cellular, Plasma Cell | | 2 1.5|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 6| 6| 7| 7| 5| 5| 6| 6| 6| 6| 2| 6| 6| 7| 5| 7| 5| 6| 5| 4| | |
DAY ON TEST | 3| 9| 0| 3| 9| 3| 0| 8| 5| 6| 5| 3| 3| 5| 3| 1| 2| 3| 1| 2| 3| 6| 8| | |
| 6| 0| 5| 5| 4| 6| 5| 0| 0| 1| 9| 4| 4| 3| 1| 4| 2| 7| 8| 9| 5| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
TRIOCT./ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
OZONE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + | 33 |
Congestion | 2 | 2 2.0|
Fibrosis | 3 3 3 2 2 | 7 2.3|
Hematopoietic Cell Proliferation | | 1 3.0|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 2 |
Galactocele | 3 | 2 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation, Suppurative | 3 | 1 3.0|
Prepuce, Inflammation, Suppurative | 2 3 3 | 3 2.7|
Subcutaneous Tissue, Skin, Site of | | |
Application, Inflammation, | | |
Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 48 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Foreign Body | | 2 |
Inflammation, Suppurative | 2 1 | 3 1.7|
Mineralization | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Edema | 3 | 1 3.0|
Hemorrhage | 2 | 2 1.5|
Mineralization | 3 | 2 3.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Alveolar Epithelium, Metaplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 35 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 | 7 1.1|
Bronchus, Inflammation, Suppurative | | 1 3.0|
Interstitium, Fibrosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3 1 | 34 1.1|
Interstitium, Inflammation, Chronic, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 6| 6| 7| 7| 5| 5| 6| 6| 6| 6| 2| 6| 6| 7| 5| 7| 5| 6| 5| 4| | |
DAY ON TEST | 3| 9| 0| 3| 9| 3| 0| 8| 5| 6| 5| 3| 3| 5| 3| 1| 2| 3| 1| 2| 3| 6| 8| | |
| 6| 0| 5| 5| 4| 6| 5| 0| 0| 1| 9| 4| 4| 3| 1| 4| 2| 7| 8| 9| 5| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
TRIOCT./ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
OZONE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Diffuse | 3 | 2 2.0|
Serosa, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation, Suppurative | 2 | 3 2.0|
Goblet Cell, Lateral Wall, | | |
Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 38 1.0|
Lateral Wall, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 46 1.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 3 2 2 2 2 2 2 3 2 2 1 3 2 1 2 2 2 2 2 2 2 2 2 | 47 2.1|
Olfactory Epithelium, Metaplasia | 1 | 1 1.0|
Turbinate, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pleura | + | 2 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + A + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Cataract | 4 | 1 4.0|
Ciliary Body, Retina, Degeneration | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 15 |
Cyst | 2 2 | 2 2.0|
Nephropathy | 3 4 3 4 4 4 4 4 | 14 3.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + | 2 |
Calculus Gross Observation | X | 1 |
Calculus Micro Observation Only | X | 1 |
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 7| 6| 4| 6| 6| 6| 5| 5| 2| 7| 6| 6| 6| 5| 5| 5| 4| 6| 5| 7| 6|
DAY ON TEST | 3| 0| 7| 4| 3| 9| 6| 7| 9| 6| 8| 6| 3| 1| 0| 6| 8| 6| 5| 6| 4| 8| 5| 1| 6|
| 6| 4| 3| 9| 6| 7| 0| 1| 8| 9| 3| 9| 4| 0| 5| 2| 3| 7| 0| 5| 4| 0| 2| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
.1M/KNNK | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
/OZONE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Intestine Large, Cecum | + |
__________________________________________________________________________|
Intestine Small, Ileum | + |
Peyer's Patch, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Degeneration, Cystic | 2 2 |
Hepatodiaphragmatic Nodule | X|
Inflammation | |
Vacuolization Cytoplasmic | 2 3 |
__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Necrosis | 1 3 3 |
__________________________________________________________________________|
Stomach, Forestomach | + |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Stomach, Glandular | + |
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Tooth | + |
Developmental Malformation | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + |
Pericardium, Fibrosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + |
__________________________________________________________________________|
Parathyroid Gland | + |
Hyperplasia | 4 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | |
__________________________________________________________________________|
Penis | + |
Calculus Micro Observation Only | X |
__________________________________________________________________________|
Preputial Gland | + |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Prostate | + |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + +|
Atrophy | 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 7| 6| 4| 6| 6| 6| 5| 5| 2| 7| 6| 6| 6| 5| 5| 5| 4| 6| 5| 7| 6|
DAY ON TEST | 3| 0| 7| 4| 3| 9| 6| 7| 9| 6| 8| 6| 3| 1| 0| 6| 8| 6| 5| 6| 4| 8| 5| 1| 6|
| 6| 4| 3| 9| 6| 7| 0| 1| 8| 9| 3| 9| 4| 0| 5| 2| 3| 7| 0| 5| 4| 0| 2| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
.1M/KNNK | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
/OZONE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + |
Pancreatic, Hyperplasia, Lymphoid | |
Renal, Hemorrhage | |
Renal, Hyperplasia, Lymphoid | 2 |
Renal, Infiltration Cellular, Plasma | |
Cell | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + M M + + + M M + M M + M + M + M + + + + M|
Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + |
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + |
Inflammation, Granulomatous | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
Congestion | 2 |
Fibrosis | 3 2 3 |
__________________________________________________________________________|
Thymus | + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 |
Hyperplasia | |
Inflammation, Chronic | 3 |
Dermis, Cyst | 3 |
Prepuce, Inflammation, Suppurative | 2 3 |
Sebaceous Gland, Hyperplasia | |
Subcutaneous Tissue, Skin, Site of | |
Application, Inflammation, | |
Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 7| 6| 4| 6| 6| 6| 5| 5| 2| 7| 6| 6| 6| 5| 5| 5| 4| 6| 5| 7| 6|
DAY ON TEST | 3| 0| 7| 4| 3| 9| 6| 7| 9| 6| 8| 6| 3| 1| 0| 6| 8| 6| 5| 6| 4| 8| 5| 1| 6|
| 6| 4| 3| 9| 6| 7| 0| 1| 8| 9| 3| 9| 4| 0| 5| 2| 3| 7| 0| 5| 4| 0| 2| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
.1M/KNNK | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
/OZONE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Edema | |
Hemorrhage | |
Alveolar Epithelium, Hyperplasia, | |
Atypical | 2 2 1 2 1 2 2 1 |
Alveolar Epithelium, Metaplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 2 1 |
Interstitium, Fibrosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 |
Thrombosis | 4 |
Goblet Cell, Lateral Wall, | |
Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1|
Lateral Wall, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 2 2 2 2 2 2 2 2 2 3 2 1 2 2 2 3 2 1 2 2 1 2 2 1|
Olfactory Epithelium, Metaplasia | |
Turbinate, Necrosis | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + |
Infarct | 2 |
Nephropathy | 2 3 3 4 3 4 4 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Urinary Bladder | + + |
Hemorrhage | 3 |
Transitional Epithelium, Necrosis | 3 |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 7| 6| 6| 5| 4| 7| 4| 5| 6| 6| 6| 7| 6| 7| 7| 6| 7| 4| 6| | |
DAY ON TEST | 8| 1| 3| 2| 3| 3| 6| 7| 9| 3| 4| 6| 4| 3| 0| 0| 8| 3| 3| 3| 2| 1| 8| | |
| 1| 3| 6| 0| 3| 5| 9| 5| 6| 6| 4| 7| 1| 8| 4| 3| 3| 6| 6| 2| 5| 6| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
.1M/KNNK | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
/OZONE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 1 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + | 36 |
Angiectasis | 2 2 | 3 2.0|
Degeneration, Cystic | 2 2 2 2 1 2 | 8 1.9|
Hepatodiaphragmatic Nodule | X X | 3 |
Inflammation | 2 | 1 2.0|
Vacuolization Cytoplasmic | 3 4 | 4 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 11 |
Fat, Necrosis | 2 2 2 2 | 7 2.1|
__________________________________________________________________________|____________|
Stomach, Forestomach | | 1 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 1 |
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Developmental Malformation | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + | 2 |
Pericardium, Fibrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 1 |
Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 27 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + + + + + + + + + + + + + + + + | 31 |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 4 1 1 1 1 | 30 1.1|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + | 1 |
__________________________________________________________________________|____________|
Penis | | 1 |
Calculus Micro Observation Only | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + | 2 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 7| 6| 6| 5| 4| 7| 4| 5| 6| 6| 6| 7| 6| 7| 7| 6| 7| 4| 6| | |
DAY ON TEST | 8| 1| 3| 2| 3| 3| 6| 7| 9| 3| 4| 6| 4| 3| 0| 0| 8| 3| 3| 3| 2| 1| 8| | |
| 1| 3| 6| 0| 3| 5| 9| 5| 6| 6| 4| 7| 1| 8| 4| 3| 3| 6| 6| 2| 5| 6| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
.1M/KNNK | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
/OZONE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 2 | 2 2.5|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + | 25 |
Atrophy | 3 4 4 | 5 3.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + | 10 |
Pancreatic, Hyperplasia, Lymphoid | 3 | 1 3.0|
Renal, Hemorrhage | 2 | 1 2.0|
Renal, Hyperplasia, Lymphoid | | 1 2.0|
Renal, Infiltration Cellular, Plasma | | |
Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + + + M M M M + + + I + + + M M M + M M | 26 |
Hemorrhage | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 7 |
Infiltration Cellular, Plasma Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 11 |
Inflammation, Granulomatous | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + M + + M + + + + + + + + + M + + M + M + | 43 |
Hemorrhage | 3 | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + | 37 |
Accessory Spleen | X | 1 |
Congestion | | 1 2.0|
Fibrosis | 2 3 2 1 2 3 3 3 3 | 12 2.5|
__________________________________________________________________________|____________|
Thymus | | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hyperkeratosis | | 1 3.0|
Hyperplasia | 3 | 1 3.0|
Inflammation, Chronic | | 1 3.0|
Dermis, Cyst | | 1 3.0|
Prepuce, Inflammation, Suppurative | 2 | 3 2.3|
Sebaceous Gland, Hyperplasia | 2 | 1 2.0|
Subcutaneous Tissue, Skin, Site of | | |
Application, Inflammation, | | |
Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 47 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 7| 6| 6| 5| 4| 7| 4| 5| 6| 6| 6| 7| 6| 7| 7| 6| 7| 4| 6| | |
DAY ON TEST | 8| 1| 3| 2| 3| 3| 6| 7| 9| 3| 4| 6| 4| 3| 0| 0| 8| 3| 3| 3| 2| 1| 8| | |
| 1| 3| 6| 0| 3| 5| 9| 5| 6| 6| 4| 7| 1| 8| 4| 3| 3| 6| 6| 2| 5| 6| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
.1M/KNNK | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
/OZONE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation, Suppurative | 2 2 | 3 1.7|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Congestion | 2 2 1 2 | 5 1.8|
Edema | 2 1 1 | 3 1.3|
Hemorrhage | 3 | 1 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Atypical | 2 1 2 2 | 12 1.7|
Alveolar Epithelium, Metaplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 47 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 1 | 9 1.1|
Interstitium, Fibrosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 46 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation, Suppurative | 3 | 3 2.3|
Thrombosis | | 1 4.0|
Goblet Cell, Lateral Wall, | | |
Hyperplasia | 1 1 2 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 | 45 1.1|
Lateral Wall, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 48 1.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 2 2 2 3 1 3 2 2 2 2 1 3 2 2 1 1 2 1 2 3 2 2 | 48 1.9|
Olfactory Epithelium, Metaplasia | 3 | 1 3.0|
Turbinate, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + I + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | + + + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + | 20 |
Infarct | | 1 2.0|
Nephropathy | 3 3 3 3 3 3 4 4 4 3 4 | 18 3.3|
Pigmentation, Hemosiderin | 4 | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + | 3 |
Hemorrhage | 2 | 2 2.5|
Transitional Epithelium, Necrosis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 6| 5| 5| 5| 2| 4| 7| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 4| 6| 6| 6| 7| 6| 5|
DAY ON TEST | 1| 6| 5| 5| 5| 5| 3| 8| 4| 0| 0| 8| 8| 6| 3| 4| 1| 5| 7| 9| 6| 4| 2| 8| 9|
| 7| 2| 8| 7| 3| 6| 6| 3| 1| 3| 3| 7| 3| 9| 6| 0| 0| 5| 0| 7| 1| 0| 5| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
1M/K NNK | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
/OZONE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Intestine Large, Cecum | + |
Ulcer | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 |
Degeneration, Cystic | 2 2 2 2 3 2 3 3 |
Hepatodiaphragmatic Nodule | X X X|
Hyperplasia, Focal | 3 2 4 3 4 4 |
Hyperplasia | 4 |
Infiltration Cellular, Mixed Cell | 3 |
Necrosis, Focal | 2 3 |
Vacuolization Cytoplasmic, Focal | 1 |
Vacuolization Cytoplasmic | 3 |
Bile Duct, Hyperplasia | 4 |
Centrilobular, Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 3 3 3 3 |
__________________________________________________________________________|
Stomach, Forestomach | |
Hyperplasia, Squamous | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Tooth | + |
Developmental Malformation | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + |
Fibrosis | 2 |
Atrium, Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Medulla | + |
__________________________________________________________________________|
Parathyroid Gland | + |
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + +|
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Penis | + |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 6| 5| 5| 5| 2| 4| 7| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 4| 6| 6| 6| 7| 6| 5|
DAY ON TEST | 1| 6| 5| 5| 5| 5| 3| 8| 4| 0| 0| 8| 8| 6| 3| 4| 1| 5| 7| 9| 6| 4| 2| 8| 9|
| 7| 2| 8| 7| 3| 6| 6| 3| 1| 3| 3| 7| 3| 9| 6| 0| 0| 5| 0| 7| 1| 0| 5| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
1M/K NNK | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
/OZONE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Edema | 2 |
__________________________________________________________________________|
Preputial Gland | + |
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + |
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + +|
Iliac, Infiltration Cellular, Plasma | |
Cell | |
Iliac, Pigmentation | |
Renal, Infiltration Cellular, Plasma | |
Cell | |
Renal, Inflammation, Granulomatous | |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + + + + M + M + + + + M + + + + M + M + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + +|
Hyperplasia, Lymphoid | |
Infiltration Cellular, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + M + + + + + + + + M + M + M + + +|
Infiltration Cellular, Plasma Cell | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X |
Fibrosis | 3 3 3 4 2 3 |
Hematopoietic Cell Proliferation | 4 |
Necrosis | 3 |
Capsule, Fibrosis | |
__________________________________________________________________________|
Thymus | + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + |
Galactocele | 3 |
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 |
Inflammation, Chronic | |
Dermis, Cyst | 3 |
Prepuce, Inflammation, Suppurative | 3 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic | 4 |
Subcutaneous Tissue, Necrosis | 4 |
Subcutaneous Tissue, Skin, Site of | |
Application, Inflammation, | |
Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 6| 5| 5| 5| 2| 4| 7| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 4| 6| 6| 6| 7| 6| 5|
DAY ON TEST | 1| 6| 5| 5| 5| 5| 3| 8| 4| 0| 0| 8| 8| 6| 3| 4| 1| 5| 7| 9| 6| 4| 2| 8| 9|
| 7| 2| 8| 7| 3| 6| 6| 3| 1| 3| 3| 7| 3| 9| 6| 0| 0| 5| 0| 7| 1| 0| 5| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
1M/K NNK | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
/OZONE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 2 |
Mineralization | 3|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Hemorrhage | 2 |
Alveolar Epithelium, Hyperplasia, | |
Atypical | 2 1 1 1 3 2 3 4 3 3 2 2 1 3 2 2 2|
Alveolar Epithelium, Metaplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 1 1 2 2 2 1 1 |
Interstitium, Fibrosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + A + + + +|
Inflammation, Suppurative | |
Goblet Cell, Lateral Wall, | |
Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Lateral Wall, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 2 3 1 2 2 1 2 2 3 3 2 2 2 1 2 2 2 1 3 1 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + A + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | +|
Cataract | 3|
Hemorrhage | |
Ciliary Body, Retina, Degeneration | 4|
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + +|
Cyst | |
Infarct | 2 |
Nephropathy | 4 3 3 3 3 4 3 3 4 3|
__________________________________________________________________________|
Urinary Bladder | |
Calculus Micro Observation Only | |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 6| 7| 7| 4| 6| 5| 6| 5| 6| 6| 5| 6| 6| 7| 5| 6| 4| 7| | |
DAY ON TEST | 0| 3| 5| 3| 0| 3| 1| 3| 1| 0| 8| 6| 8| 7| 1| 8| 3| 8| 0| 8| 7| 0| 0| | |
| 3| 6| 7| 6| 5| 5| 2| 6| 6| 2| 5| 9| 0| 1| 3| 2| 5| 7| 0| 1| 8| 3| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
1M/K NNK | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
/OZONE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 2 |
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + | 42 |
Angiectasis | 3 2 3 | 5 2.6|
Degeneration, Cystic | 2 3 2 2 2 2 2 3 2 | 17 2.3|
Hepatodiaphragmatic Nodule | X X | 5 |
Hyperplasia, Focal | 3 | 7 3.3|
Hyperplasia | 3 | 2 3.5|
Infiltration Cellular, Mixed Cell | | 1 3.0|
Necrosis, Focal | 3 | 3 2.7|
Vacuolization Cytoplasmic, Focal | | 1 1.0|
Vacuolization Cytoplasmic | 2 | 2 2.5|
Bile Duct, Hyperplasia | | 1 4.0|
Centrilobular, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 8 |
Fat, Necrosis | 3 2 3 2 | 8 2.8|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 2 |
Hyperplasia, Squamous | 2 2 | 2 2.0|
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Developmental Malformation | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 2 |
Fibrosis | | 1 2.0|
Atrium, Thrombosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Medulla | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 1 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + | 30 |
Pars Distalis, Hemorrhage | 4 | 1 4.0|
Pars Distalis, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + + + + + + + + + + + + + | 26 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 6| 7| 7| 4| 6| 5| 6| 5| 6| 6| 5| 6| 6| 7| 5| 6| 4| 7| | |
DAY ON TEST | 0| 3| 5| 3| 0| 3| 1| 3| 1| 0| 8| 6| 8| 7| 1| 8| 3| 8| 0| 8| 7| 0| 0| | |
| 3| 6| 7| 6| 5| 5| 2| 6| 6| 2| 5| 9| 0| 1| 3| 2| 5| 7| 0| 1| 8| 3| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
1M/K NNK | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
/OZONE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 26 1.0|
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Penis | + | 2 |
Edema | 1 | 2 1.5|
__________________________________________________________________________|____________|
Preputial Gland | + + | 3 |
Inflammation, Chronic Active | 2 3 | 3 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + | 19 |
Atrophy | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + | 17 |
Iliac, Infiltration Cellular, Plasma | | |
Cell | 3 | 1 3.0|
Iliac, Pigmentation | 2 | 1 2.0|
Renal, Infiltration Cellular, Plasma | | |
Cell | 2 | 1 2.0|
Renal, Inflammation, Granulomatous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M + M M M + M + M M M M + + + + M + M + + + | 30 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + | 15 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
Infiltration Cellular, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 8 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + M + + + + + + + + + + | 43 |
Infiltration Cellular, Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + | 39 |
Accessory Spleen | | 1 |
Fibrosis | 2 3 3 2 2 3 3 | 13 2.8|
Hematopoietic Cell Proliferation | | 1 4.0|
Necrosis | | 1 3.0|
Capsule, Fibrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + | 4 |
Galactocele | 3 | 2 3.0|
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 6| 7| 7| 4| 6| 5| 6| 5| 6| 6| 5| 6| 6| 7| 5| 6| 4| 7| | |
DAY ON TEST | 0| 3| 5| 3| 0| 3| 1| 3| 1| 0| 8| 6| 8| 7| 1| 8| 3| 8| 0| 8| 7| 0| 0| | |
| 3| 6| 7| 6| 5| 5| 2| 6| 6| 2| 5| 9| 0| 1| 3| 2| 5| 7| 0| 1| 8| 3| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
1M/K NNK | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
/OZONE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Hyperkeratosis | 2 | 2 2.5|
Inflammation, Chronic | 2 | 1 2.0|
Dermis, Cyst | | 1 3.0|
Prepuce, Inflammation, Suppurative | | 2 2.5|
Subcutaneous Tissue, Inflammation, | | |
Chronic | | 1 4.0|
Subcutaneous Tissue, Necrosis | | 1 4.0|
Subcutaneous Tissue, Skin, Site of | | |
Application, Inflammation, | | |
Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 48 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation, Suppurative | 1 1 1 1 | 6 1.2|
Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Edema | | 1 2.0|
Hemorrhage | 3 1 | 3 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Atypical | 2 2 2 2 2 1 2 2 2 3 2 2 1 2 3 2 | 33 2.1|
Alveolar Epithelium, Metaplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 45 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 2 1 2 2 | 13 1.6|
Interstitium, Fibrosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 45 1.0|
__________________________________________________________________________|____________|
Nose | A + + + + + + + + + + + + + + + + + + + + + + | 46 |
Inflammation, Suppurative | 2 | 1 2.0|
Goblet Cell, Lateral Wall, | | |
Hyperplasia | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 42 1.0|
Lateral Wall, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 46 1.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 3 2 2 1 2 2 2 2 2 1 2 1 3 2 2 1 2 2 2 1 2 | 46 1.9|
__________________________________________________________________________|____________|
Trachea | A + + + + + + + + + + + + + + + + + + + + + + | 46 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OZONE/NNK Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 6| 7| 7| 4| 6| 5| 6| 5| 6| 6| 5| 6| 6| 7| 5| 6| 4| 7| | |
DAY ON TEST | 0| 3| 5| 3| 0| 3| 1| 3| 1| 0| 8| 6| 8| 7| 1| 8| 3| 8| 0| 8| 7| 0| 0| | |
| 3| 6| 7| 6| 5| 5| 2| 6| 6| 2| 5| 9| 0| 1| 3| 2| 5| 7| 0| 1| 8| 3| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
1M/K NNK | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L |
/OZONE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 4 |
Cataract | 2 | 2 2.5|
Hemorrhage | 2 | 1 2.0|
Ciliary Body, Retina, Degeneration | 3 | 2 3.5|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + | 25 |
Cyst | 2 | 1 2.0|
Infarct | | 1 2.0|
Nephropathy | 3 3 4 3 3 3 3 3 3 3 2 3 | 22 3.1|
__________________________________________________________________________|____________|
Urinary Bladder | + | 1 |
Calculus Micro Observation Only | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
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---------- END OF REPORT ----------
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