TDMS Study 88034-07 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest DATE: 05/08/95
EXP: 88034 OZONE/NNK TIME: 23:09:18
TEST: 07 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 88034C
CONT: N01-ES-95262 CAS: 10028-15-6
PATHOLOGIST: P. MELLICK
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest DATE: 05/08/95
EXP: 88034 OZONE/NNK TIME: 23:09:18
TEST: 07 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 88034C
CONT: N01-ES-95262 CAS: 10028-15-6
PATHOLOGIST: P. MELLICK
OZONE/NNK
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 736 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = TRIOCT./AIR |
| --------------------- |
| |
| TOTAL 48 UNCENSORED DEATHS 40 CENSORED DEATHS 0 TERMINAL 8 |
| |
| UNCENSORED DEATHS |
| 327 466 484 515 540 543 556 556 562 564 |
| 569 576 585 589 604 611 611 613 620 620 |
| 633 638 641 655 663 664 669 672 673 681 |
| 692 697 698 700 700 704 706 709 717 724 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = .1MG/KG NNK/AIR |
| ---------------------------- |
| |
| TOTAL 48 UNCENSORED DEATHS 42 CENSORED DEATHS 0 TERMINAL 6 |
| |
| UNCENSORED DEATHS |
| 417 444 460 466 478 501 501 518 529 544 |
| 550 551 555 557 579 582 589 589 612 613 |
| 617 620 625 633 635 635 639 641 641 655 |
| 662 663 671 673 683 686 697 704 704 710 |
| 715 716 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = TRIOCT./OZONE |
| ---------------------------- |
| |
| TOTAL 48 UNCENSORED DEATHS 45 CENSORED DEATHS 0 TERMINAL 3 |
| |
| UNCENSORED DEATHS |
| 192 253 333 389 440 458 487 502 515 523 |
| 529 537 550 556 560 580 589 590 592 603 |
| 605 611 614 617 624 631 634 634 635 635 |
| 636 645 659 661 669 673 678 694 704 705 |
| 709 712 718 722 725 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
OZONE/NNK
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 736 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = .1M/KNNK/OZONE |
| ---------------------------- |
| |
| TOTAL 48 UNCENSORED DEATHS 42 CENSORED DEATHS 0 TERMINAL 6 |
| |
| UNCENSORED DEATHS |
| 234 416 444 444 460 481 496 549 550 552 |
| 565 567 567 569 575 583 604 604 605 620 |
| 632 635 638 641 662 663 669 669 671 673 |
| 680 683 683 683 697 698 703 710 713 714 |
| 725 733 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1M/K NNK/OZONE |
| ---------------------------- |
| |
| TOTAL 48 UNCENSORED DEATHS 43 CENSORED DEATHS 0 TERMINAL 5 |
| |
| UNCENSORED DEATHS |
| 253 403 416 456 470 503 557 557 558 562 |
| 580 581 582 585 597 602 603 603 610 613 |
| 617 635 635 640 640 641 655 661 669 669 |
| 671 678 683 683 683 687 687 697 700 704 |
| 705 712 725 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1 MG/KG NNK/AIR |
| ---------------------------- |
| |
| TOTAL 48 UNCENSORED DEATHS 44 CENSORED DEATHS 0 TERMINAL 4 |
| |
| UNCENSORED DEATHS |
| 429 450 486 488 489 528 529 533 540 544 |
| 550 551 562 579 583 583 590 590 602 603 |
| 603 603 604 605 605 617 639 641 645 661 |
| 663 669 677 678 683 683 683 683 687 695 |
| 695 704 712 715 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
OZONE/NNK
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 736 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 736 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|TRIOCT./AIR| 100.0 100.0 100.0 97.9 97.9 93.8 87.5 68.8 45.8 16.7 |
| | |
| | |
|.1MG/KG | 100.0 100.0 100.0 100.0 97.9 89.6 79.2 62.5 33.3 12.5 |
|NNK/AIR | |
| | |
|TRIOCT./OZO|E 100.0 100.0 95.8 93.8 91.7 87.5 75.0 56.3 29.2 6.3 |
| | |
| | |
|.1M/KNNK/OZ|NE 100.0 100.0 97.9 97.9 95.8 87.5 85.4 60.4 45.8 12.5 |
| | |
| | |
|1M/K | 100.0 100.0 97.9 97.9 93.8 89.6 87.5 62.5 41.7 10.4 |
|NNK/OZONE | |
| | |
|1 | 100.0 100.0 100.0 100.0 100.0 95.8 79.2 47.9 35.4 8.3 |
|MG/KG NNK/A|R |
| | |
==================================================================================
OZONE/NNK
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 736 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| TRIOCT./AIR .1MG/KG TRIOCT./OZONE .1M/KNNK/OZONE 1M/K 1 |
| NNK/AIR NNK/OZONE MG/KG NNK/AIR|
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 16.7% 12.5% 6.3% 12.5% 10.4% 8.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.172 P=0.370 P=0.094 P=0.666 P=0.394 P=0.122 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 618.7 601.4 585.1 606.2 608.6 605.9 |
|NATURAL DEATHS (C) | (13.0) (12.5) (17.7) (15.9) (14.6) (11.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 638.2 618.3 594.5 622.4 621.8 616.7 |
|(STANDARD ERROR) | (12.5) (12.7) (17.4) (15.2) (14.3) (11.5) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
OZONE/NNK
KAPLAN-MEIER SURVIVAL CURVES
TRIOCT./AIR = 1
.1MG/KG NNK/AIR = 2
TRIOCT./OZONE = 3
.1M/KNNK/OZONE = 4
1M/K NNK/OZONE = 5
1 MG/KG NNK/AIR = 6
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100.00 +1 3 4 3 1 5 2 6 2 6 1
| 3 3 3 5 4 2 621 1 1
| 3 34 32526 2 1 6 1
| 3 4342 2 66141
P 83.33 + 3 2 3262 11
E | 33322 111
R | 3 224411 1
C | 2 422 1511
E 66.67 + 32 254
N | 26311
T | 321 11
| 32221 1
S 50.00 + 6 3334 1 1
U | 6 22 5 11
R | 262 5111
V | 3 32 254111
I 33.33 + 3 2225
V | 3322511
A | 325211
L | 6632111
16.67 + 63221 41
| 6323 42
| 63 3
|
0.00 +
|
-+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 164 obs hidden.