TDMS Study 88035-05 Pathology Tables
NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 CORE STUDY Facility: Battelle Columbus Laboratory Chemical CAS #: 0000125-33-7 Lock Date: 11/17/94 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 _____________________________________________________________________________________________________________________ | 6| 6| 6| 4| 7| 7| 7| 6| 7| 5| 6| 5| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| DAY ON TEST | 6| 9| 7| 1| 2| 2| 2| 2| 2| 4| 8| 6| 2| 4| 2| 6| 2| 0| 6| 2| 0| 2| 2| 2| 6| | 0| 7| 5| 5| 3| 3| 3| 6| 3| 1| 2| 6| 2| 1| 4| 4| 4| 3| 8| 4| 2| 3| 3| 2| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + A + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Basophilic Focus | X X X X X X X X X X X X X X X X X X X X | Clear Cell Focus | X X | Eosinophilic Focus | X | Hepatodiaphragmatic Nodule | | Inflammation, Chronic | 2 1 1 1 2 1 2 2 2 1 2 2 1 2 1 2 2 2 2 | Mixed Cell Focus | X X X | Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 1 1 1 1 3 1 1 2| Bile Duct, Hyperplasia | 1 2 1 1 1 1 2 2 1 3 1 1 1 1 1 | Hepatocyte, Degeneration | 4 | Hepatocyte, Necrosis | 2 2 1 1| Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 4 3 2 2 1 1 2 1 1 2 4| Hepatocyte, Centrilobular, | | Hypertrophy | | __________________________________________________________________________| Mesentery | + + + + | Accessory Spleen | | Fat, Necrosis | 4 4 4 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Acinus, Atrophy | 1 2 1 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Epithelium, Hyperplasia | 2 3 | Epithelium, Inflammation, Chronic | | Active | 4 | Epithelium, Ulcer | 4 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy, Chronic | 2 2 1 2 2 2 2 | Atrium, Thrombosis | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 _____________________________________________________________________________________________________________________ | 6| 6| 6| 4| 7| 7| 7| 6| 7| 5| 6| 5| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| DAY ON TEST | 6| 9| 7| 1| 2| 2| 2| 2| 2| 4| 8| 6| 2| 4| 2| 6| 2| 0| 6| 2| 0| 2| 2| 2| 6| | 0| 7| 5| 5| 3| 3| 3| 6| 3| 1| 2| 6| 2| 1| 4| 4| 4| 3| 8| 4| 2| 3| 3| 2| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Fatty | 1 1 1 1 3 1 3| Hyperplasia | 2 2 | Hypertrophy | | Necrosis | 3 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 2 1 2 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + M + + + + + M M + + + + + + + + + M + + M + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Pars Distalis, Cyst | 3 1 2 2 2 3 3 2 2 2 2 2 | Pars Distalis, Hyperplasia | 2 2 3 2 2 2 2 2 3 2 4 2 2 3 3| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 1 1 2 3 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 3 2 2 2 4 4 4 2 | Inflammation, Chronic Active | 1 2 2 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 3 4 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Hydrometra | 3 3 | Hyperplasia, Cystic | 2 | Inflammation, Chronic Active | | __________________________________________________________________________| Vagina | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 4 | Hyperplasia, Mast Cell | 4 | Hyperplasia | | Myelofibrosis | 2 3 1| __________________________________________________________________________| Lymph Node | + + + + + + + | Mediastinal, Hyperplasia, Histiocytic| 3 | Mediastinal, Necrosis | 3 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 _____________________________________________________________________________________________________________________ | 6| 6| 6| 4| 7| 7| 7| 6| 7| 5| 6| 5| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| DAY ON TEST | 6| 9| 7| 1| 2| 2| 2| 2| 2| 4| 8| 6| 2| 4| 2| 6| 2| 0| 6| 2| 0| 2| 2| 2| 6| | 0| 7| 5| 5| 3| 3| 3| 6| 3| 1| 2| 6| 2| 1| 4| 4| 4| 3| 8| 4| 2| 3| 3| 2| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Accessory Spleen | | Fibrosis | | Hematopoietic Cell Proliferation | 2 | Necrosis | 4 4 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 4 | Hyperplasia, Cystic | 2 3 2 2 2 3 2 3 2 2 2 3 1 2 3 2| Inflammation, Chronic Active | 4 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | 3 | Epidermis, Hyperplasia | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteopetrosis | 4 2| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 1 | Hydrocephalus | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Necrosis | | Alveolar Epithelium, Hyperplasia | 1 3 2 3 | Alveolus, Infiltration Cellular, | | Histiocyte | 1 2 1 1 1 1 1 1 1 1 1 1 1 1| Artery, Vein, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Perivascular, Infiltration Cellular, | | Lymphocyte | 1 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | Inflammation, Suppurative | 2 | Nasolacrimal Duct, Inflammation, | | Suppurative | 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | Lens, Cataract | | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 _____________________________________________________________________________________________________________________ | 6| 6| 6| 4| 7| 7| 7| 6| 7| 5| 6| 5| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| DAY ON TEST | 6| 9| 7| 1| 2| 2| 2| 2| 2| 4| 8| 6| 2| 4| 2| 6| 2| 0| 6| 2| 0| 2| 2| 2| 6| | 0| 7| 5| 5| 3| 3| 3| 6| 3| 1| 2| 6| 2| 1| 4| 4| 4| 3| 8| 4| 2| 3| 3| 2| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Retina, Degeneration | | __________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 1 1 1 1 1 1 1 1 | Nephropathy, Chronic | 1 1 1 1 1 2 1 1 2 2 1 1 1 1 2 2 1 1 2 2 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 5 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 6| 7| 7| 5| 5| 7| 3| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| | DAY ON TEST | 2| 2| 2| 2| 4| 2| 2| 2| 6| 3| 0| 6| 0| 2| 2| 0| 2| 2| 3| 4| 2| 3| 4| 2| 2| | | 4| 3| 2| 4| 6| 6| 4| 4| 1| 6| 2| 7| 2| 3| 4| 2| 4| 3| 8| 1| 3| 4| 0| 3| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 3 | 2 2.5| Basophilic Focus | X X X X X X X X X X X X X X X X X X X| 39 | Clear Cell Focus | X X X X | 6 | Eosinophilic Focus | X | 2 | Hepatodiaphragmatic Nodule | X X X X X | 5 | Inflammation, Chronic | 2 1 1 1 2 2 2 2 1 1 1 1 2 1 1 1 2 2 1| 38 1.5| Mixed Cell Focus | X X | 5 | Pigmentation, Hemosiderin | 1 2 1 1 1 1 1 1 2 1 | 25 1.2| Bile Duct, Hyperplasia | 1 3 1 2 1 2 1 2 2 1 1 1 2 1 1| 30 1.4| Hepatocyte, Degeneration | | 1 4.0| Hepatocyte, Necrosis | | 4 1.5| Hepatocyte, Vacuolization Cytoplasmic| 1 1 4 1 4 1 1 2 1 2 1 | 25 1.8| Hepatocyte, Centrilobular, | | | Hypertrophy | 2 | 1 2.0| __________________________________________________________________________|____________| Mesentery | + + + + + | 9 | Accessory Spleen | X | 1 | Fat, Necrosis | 4 4 4 4 | 7 4.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 | Cyst | 2 | 1 2.0| Acinus, Atrophy | 2 1 1 1 | 8 1.4| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 | Epithelium, Hyperplasia | 2 3 | 4 2.5| Epithelium, Inflammation, Chronic | | | Active | 4 | 2 4.0| Epithelium, Ulcer | 4 | 2 4.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 6 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 6| 7| 7| 5| 5| 7| 3| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| | DAY ON TEST | 2| 2| 2| 2| 4| 2| 2| 2| 6| 3| 0| 6| 0| 2| 2| 0| 2| 2| 3| 4| 2| 3| 4| 2| 2| | | 4| 3| 2| 4| 6| 6| 4| 4| 1| 6| 2| 7| 2| 3| 4| 2| 4| 3| 8| 1| 3| 4| 0| 3| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 | Cardiomyopathy, Chronic | 2 1 2 2 2 1 1 1 2 2 2 1 1 2| 21 1.7| Atrium, Thrombosis | | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Fatty | 2 2 3 1 1 2 | 13 1.7| Hyperplasia | 2 2 1 1 2 2 1 2 | 10 1.7| Hypertrophy | 1 | 1 1.0| Necrosis | | 1 3.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 | 6 1.5| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | M + + + + M + + + M + + + M + + + + + + M M M + +| 38 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 | Angiectasis | 1 | 1 1.0| Pars Distalis, Cyst | 2 2 2 2 1 2 1 2 2 4 2 2| 24 2.1| Pars Distalis, Hyperplasia | 2 2 3 2 2 2 2 2 2 3 2 | 26 2.3| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 | C-Cell, Hyperplasia | 1 2 1 1 1 2 1 1 1 | 14 1.4| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 | Hyperplasia | 2 2 4 | 12 2.8| Inflammation, Chronic Active | 1 | 4 1.5| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 3 3.3| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 4 | 1 4.0| Hydrometra | | 2 3.0| Hyperplasia, Cystic | 2 | 2 2.0| Inflammation, Chronic Active | 2 | 1 2.0| __________________________________________________________________________|____________| Vagina | + | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 7 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 6| 7| 7| 5| 5| 7| 3| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| | DAY ON TEST | 2| 2| 2| 2| 4| 2| 2| 2| 6| 3| 0| 6| 0| 2| 2| 0| 2| 2| 3| 4| 2| 3| 4| 2| 2| | | 4| 3| 2| 4| 6| 6| 4| 4| 1| 6| 2| 7| 2| 3| 4| 2| 4| 3| 8| 1| 3| 4| 0| 3| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Hyperplasia | | 2 4.0| Hyperplasia, Mast Cell | | 1 4.0| Hyperplasia | 3 3 3 | 3 3.0| Myelofibrosis | 2 | 4 2.0| __________________________________________________________________________|____________| Lymph Node | + + + +| 11 | Mediastinal, Hyperplasia, Histiocytic| | 1 3.0| Mediastinal, Necrosis | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 | Accessory Spleen | X X | 2 | Fibrosis | 3| 1 3.0| Hematopoietic Cell Proliferation | 3 | 2 2.5| Necrosis | | 2 4.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 4.0| Hyperplasia, Cystic | 3 1 2 2 2 2 3 1 2 2 2 3 4 3 2 2 3 3 2 2 2| 37 2.3| Inflammation, Chronic Active | | 1 4.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperkeratosis | | 1 3.0| Epidermis, Hyperplasia | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteopetrosis | | 2 3.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 1 1.0| Hydrocephalus | | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | 2 | 1 2.0| Necrosis | 3 | 1 3.0| Alveolar Epithelium, Hyperplasia | 3| 5 2.4| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 6| 7| 7| 5| 5| 7| 3| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| | DAY ON TEST | 2| 2| 2| 2| 4| 2| 2| 2| 6| 3| 0| 6| 0| 2| 2| 0| 2| 2| 3| 4| 2| 3| 4| 2| 2| | | 4| 3| 2| 4| 6| 6| 4| 4| 1| 6| 2| 7| 2| 3| 4| 2| 4| 3| 8| 1| 3| 4| 0| 3| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Alveolus, Infiltration Cellular, | | | Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1| 36 1.1| Artery, Vein, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 38 1.0| Perivascular, Infiltration Cellular, | | | Lymphocyte | 1 2 | 4 1.5| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 3 | 2 2.5| Inflammation, Suppurative | | 1 2.0| Nasolacrimal Duct, Inflammation, | | | Suppurative | 2 | 2 1.5| __________________________________________________________________________|____________| Trachea | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | Lens, Cataract | 2 | 1 2.0| Retina, Degeneration | 3 | 1 3.0| __________________________________________________________________________|____________| Zymbal's Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 1 2 1 1 | 12 1.1| Nephropathy, Chronic | 2 1 1 2 1 2 2 2 1 1 1 1 1 1 2 1 3 1 1 1 2 2| 43 1.4| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 9 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 _____________________________________________________________________________________________________________________ | 5| 7| 5| 7| 7| 7| 4| 7| 7| 7| 6| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 4| DAY ON TEST | 7| 2| 7| 2| 2| 2| 1| 2| 2| 2| 1| 1| 2| 1| 2| 2| 2| 0| 2| 2| 2| 2| 2| 8| 6| | 8| 4| 8| 3| 3| 3| 9| 2| 2| 4| 8| 5| 4| 0| 4| 3| 3| 2| 6| 3| 3| 3| 4| 2| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.06% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X X X X X X X X X X X X X X X | Clear Cell Focus | X X | Hematopoietic Cell Proliferation | | Hepatodiaphragmatic Nodule | X X X X X X | Inflammation, Chronic | 2 3 2 3 3 3 3 2 2 2 3 1 2 2 3 2 3 2 2 2 | Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 1 2 | Bile Duct, Hyperplasia | 1 1 2 1 1 1 2 1 1 1 1 3 2| Hepatocyte, Degeneration, Cystic | 2 | Hepatocyte, Necrosis | | Hepatocyte, Vacuolization Cytoplasmic| 1 2 2 1 3 3 2 3 2 1 3 1 2 3 2 3 2 2 2 3 3| Hepatocyte, Centrilobular, | | Degeneration | | Hepatocyte, Centrilobular, | | Hypertrophy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | __________________________________________________________________________| Mesentery | + + + + +| Fat, Inflammation, Chronic Active | 3 | Fat, Necrosis | 4 4 4 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | Acinus, Atrophy | 1 1 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Parotid Gland, Atrophy | | Parotid Gland, Inflammation, Chronic | | Active | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Epithelium, Hyperplasia | 2 | Epithelium, Inflammation, Chronic | | Active | | Epithelium, Ulcer | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Epithelium, Erosion | 2 | Epithelium, Inflammation, Chronic | | Active | | Epithelium, Ulcer | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | _____________________________________________________________________________________________________________________| Page 10 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 _____________________________________________________________________________________________________________________ | 5| 7| 5| 7| 7| 7| 4| 7| 7| 7| 6| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 4| DAY ON TEST | 7| 2| 7| 2| 2| 2| 1| 2| 2| 2| 1| 1| 2| 1| 2| 2| 2| 0| 2| 2| 2| 2| 2| 8| 6| | 8| 4| 8| 3| 3| 3| 9| 2| 2| 4| 8| 5| 4| 0| 4| 3| 3| 2| 6| 3| 3| 3| 4| 2| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.06% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy, Chronic | 2 2 1 1 1 1 2 2 2 1 1 2 2 2 2 2 2 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Fatty | 2 2 1 1 | Hyperplasia | 2 1 2 2 1 1 | Hypertrophy | | Inflammation, Granulomatous | 1 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 2 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + M + M + + + + + + + + + + + + + M + + + M + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | 2 2 2 2 2 2 2 2 4 | Pars Distalis, Hyperplasia | 2 2 2 2 2 2 2 2 2 3 2 2 2 2| Pars Intermedia, Cyst | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 2 1 2 1 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 4 | Hyperplasia | 2 2 | Inflammation, Chronic Active | 1 1 3 2 1| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3| Cyst | 2 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Edema | 4 | Hemorrhage | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4| Hyperplasia, Histiocytic | 3 | Hyperplasia | 3 3 | Myelofibrosis | | _____________________________________________________________________________________________________________________| Page 11 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 _____________________________________________________________________________________________________________________ | 5| 7| 5| 7| 7| 7| 4| 7| 7| 7| 6| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 4| DAY ON TEST | 7| 2| 7| 2| 2| 2| 1| 2| 2| 2| 1| 1| 2| 1| 2| 2| 2| 0| 2| 2| 2| 2| 2| 8| 6| | 8| 4| 8| 3| 3| 3| 9| 2| 2| 4| 8| 5| 4| 0| 4| 3| 3| 2| 6| 3| 3| 3| 4| 2| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.06% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node | + + +| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 | Hematopoietic Cell Proliferation | 3 | Necrosis | 4| __________________________________________________________________________| Thymus | + + + + M + + + + M + + + + + + + + + M + + + + +| Cyst | 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Cystic | 2 2 2 3 2 3 2 3 2 3 2 1 2 3 2 3 2 1 2 2 2 1 3 2| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteopetrosis | 4 3| __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 2 | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 2 | Alveolar Epithelium, Hyperplasia | 2 | Alveolus, Infiltration Cellular, | | Histiocyte | 1 1 1 1 1 1 1 1 2 1 1 2 1 2 2 1 2 1 1 1 1 | Artery, Vein, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Perivascular, Infiltration Cellular, | | Lymphocyte | 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + M + + + + + + + +| Inflammation, Suppurative | | Nasolacrimal Duct, Inflammation, | | Suppurative | 2 4 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | Lens, Cataract | | Retina, Degeneration | | _____________________________________________________________________________________________________________________| Page 12 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 _____________________________________________________________________________________________________________________ | 5| 7| 5| 7| 7| 7| 4| 7| 7| 7| 6| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 4| DAY ON TEST | 7| 2| 7| 2| 2| 2| 1| 2| 2| 2| 1| 1| 2| 1| 2| 2| 2| 0| 2| 2| 2| 2| 2| 8| 6| | 8| 4| 8| 3| 3| 3| 9| 2| 2| 4| 8| 5| 4| 0| 4| 3| 3| 2| 6| 3| 3| 3| 4| 2| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.06% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Mineralization | 1 1 1 1 1 1 2 1| Nephropathy, Chronic | 1 1 1 2 2 1 2 2 1 2 1 2 2 2 1 2 2 1 3 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| Page 13 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 6| 5| 5| 6| 7| 7| 7| 7| 6| 7| 7| 6| 3| 5| | DAY ON TEST | 2| 2| 2| 7| 7| 2| 2| 2| 5| 0| 2| 1| 1| 8| 7| 2| 2| 2| 2| 1| 0| 2| 4| 6| 6| | | 4| 4| 3| 5| 5| 4| 4| 3| 6| 5| 4| 8| 1| 4| 5| 4| 2| 4| 3| 2| 2| 3| 5| 7| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 0.06% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X | 2 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X X X X X X X X X X X X X | 35 | Clear Cell Focus | X X X | 5 | Hematopoietic Cell Proliferation | 1 | 1 1.0| Hepatodiaphragmatic Nodule | X X X X X X X | 13 | Inflammation, Chronic | 3 2 2 1 2 2 2 2 2 1 2 2 3 2 2 1 1 1 | 38 2.1| Pigmentation, Hemosiderin | 1 1 1 1 1 | 14 1.1| Bile Duct, Hyperplasia | 1 1 1 1 1 1 2 2 1 1 | 23 1.3| Hepatocyte, Degeneration, Cystic | | 1 2.0| Hepatocyte, Necrosis | 2 | 1 2.0| Hepatocyte, Vacuolization Cytoplasmic| 3 2 2 1 3 2 2 1 1 2 2 3 1 3 2 2 2 2 2 2 1 1 2| 44 2.0| Hepatocyte, Centrilobular, | | | Degeneration | 3 | 1 3.0| Hepatocyte, Centrilobular, | | | Hypertrophy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 36 1.0| __________________________________________________________________________|____________| Mesentery | + + + + +| 10 | Fat, Inflammation, Chronic Active | | 1 3.0| Fat, Necrosis | 4 4 | 5 4.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 2.0| Acinus, Atrophy | 2 2 1 1 1 | 7 1.3| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parotid Gland, Atrophy | 2 | 1 2.0| Parotid Gland, Inflammation, Chronic | | | Active | 1 | 1 1.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Epithelium, Hyperplasia | 2 2 3| 4 2.3| Epithelium, Inflammation, Chronic | | | Active | 2 1| 2 1.5| Epithelium, Ulcer | 4 4| 2 4.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 14 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 6| 5| 5| 6| 7| 7| 7| 7| 6| 7| 7| 6| 3| 5| | DAY ON TEST | 2| 2| 2| 7| 7| 2| 2| 2| 5| 0| 2| 1| 1| 8| 7| 2| 2| 2| 2| 1| 0| 2| 4| 6| 6| | | 4| 4| 3| 5| 5| 4| 4| 3| 6| 5| 4| 8| 1| 4| 5| 4| 2| 4| 3| 2| 2| 3| 5| 7| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 0.06% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Epithelium, Erosion | 1 | 2 1.5| Epithelium, Inflammation, Chronic | | | Active | 2| 1 2.0| Epithelium, Ulcer | 4| 1 4.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy, Chronic | 2 2 1 1 1 2 2 2 2 2 1| 29 1.6| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Fatty | 3 1 3 2 2 1 4| 11 2.0| Hyperplasia | 2 1 | 8 1.5| Hypertrophy | 2 | 1 2.0| Inflammation, Granulomatous | | 1 1.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 1 | 5 1.6| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + M + + +| 44 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Cyst | 3 3 2 2 2 3 2 2 1 2 1 2 2 1 2| 24 2.1| Pars Distalis, Hyperplasia | 3 2 2 3 2 2 3 1 2 3 2 | 25 2.2| Pars Intermedia, Cyst | 2 | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 2 1 1 1 1 1 1 1 2 | 15 1.3| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 | Cyst | 3 | 2 3.5| Hyperplasia | 4 1 2 | 5 2.2| Inflammation, Chronic Active | 1 2 1 3 2 | 10 1.7| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 3.0| Cyst | 2 3 3 | 4 2.5| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 15 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 6| 5| 5| 6| 7| 7| 7| 7| 6| 7| 7| 6| 3| 5| | DAY ON TEST | 2| 2| 2| 7| 7| 2| 2| 2| 5| 0| 2| 1| 1| 8| 7| 2| 2| 2| 2| 1| 0| 2| 4| 6| 6| | | 4| 4| 3| 5| 5| 4| 4| 3| 6| 5| 4| 8| 1| 4| 5| 4| 2| 4| 3| 2| 2| 3| 5| 7| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 0.06% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Angiectasis | | 1 2.0| Edema | | 1 4.0| Hemorrhage | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 4.0| Hyperplasia, Histiocytic | 4 2 | 3 3.0| Hyperplasia | 3 3 4 2 3 2 2 3 | 10 2.8| Myelofibrosis | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node | + + + +| 7 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | | 1 2.0| Hematopoietic Cell Proliferation | 3 3 | 3 3.0| Necrosis | | 1 4.0| __________________________________________________________________________|____________| Thymus | + + M + + + + + + + + + + + + + M + + + + + + + +| 45 | Cyst | | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Cystic | 2 3 2 2 2 2 2 2 1 4 1 2 3 2 2 2 3 4 2 2| 44 2.2| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteopetrosis | 4 2 2 | 5 3.0| __________________________________________________________________________|____________| Skeletal Muscle | +| 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 2 | 3 2.0| __________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 1 1 | 4 1.5| Alveolar Epithelium, Hyperplasia | 2 2 2 2 | 5 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 16 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 6| 5| 5| 6| 7| 7| 7| 7| 6| 7| 7| 6| 3| 5| | DAY ON TEST | 2| 2| 2| 7| 7| 2| 2| 2| 5| 0| 2| 1| 1| 8| 7| 2| 2| 2| 2| 1| 0| 2| 4| 6| 6| | | 4| 4| 3| 5| 5| 4| 4| 3| 6| 5| 4| 8| 1| 4| 5| 4| 2| 4| 3| 2| 2| 3| 5| 7| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 0.06% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Alveolus, Infiltration Cellular, | | | Histiocyte | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1| 44 1.2| Artery, Vein, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 39 1.0| Perivascular, Infiltration Cellular, | | | Lymphocyte | | 1 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Suppurative | 1 | 1 1.0| Nasolacrimal Duct, Inflammation, | | | Suppurative | 3| 3 3.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | Lens, Cataract | 4 | 1 4.0| Retina, Degeneration | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 3 | 1 3.0| Mineralization | 1 1 | 10 1.1| Nephropathy, Chronic | 1 3 2 1 1 2 2 1 1 1 2 1 1 1 1 1 2 2 2 1 1 2 2 | 43 1.5| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 17 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 6| 7| DAY ON TEST | 2| 2| 8| 2| 2| 0| 4| 2| 2| 2| 0| 0| 9| 2| 2| 2| 2| 2| 3| 2| 2| 8| 2| 6| 2| | 3| 2| 2| 3| 3| 3| 3| 2| 4| 2| 3| 7| 0| 4| 4| 3| 4| 2| 4| 4| 4| 9| 4| 8| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.13% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Basophilic Focus | X X X X X X X X X X X X X X X X X X X| Eosinophilic Focus | X | Hepatodiaphragmatic Nodule | X X X X X X X X X | Inflammation, Chronic | 3 2 1 3 2 1 2 3 1 2 2 3 3 2 3 2 1 2 1 1 2 2| Mixed Cell Focus | | Pigmentation, Hemosiderin | 1 1 2 1 1 2 2 | Bile Duct, Hyperplasia | 1 1 1 2 2 1 1 2 1 1 2 1 1 2 2 1 1 1 1| Hepatocyte, Necrosis | 1 2 | Hepatocyte, Vacuolization Cytoplasmic| 3 2 2 2 2 1 1 2 3 2 1 1 1 2 2 2 3 2 3 1 1 1 2 1| Hepatocyte, Centrilobular, | | Hypertrophy | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2| __________________________________________________________________________| Mesentery | + + + | Fat, Necrosis | 4 4 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Acinus, Atrophy | 2 1 1 1 2| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Basal Cell | | Epithelium, Hyperplasia | 3 | Epithelium, Inflammation, Chronic | | Active | 3 | Epithelium, Ulcer | 4 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy, Chronic | 2 2 2 2 1 2 1 1 2 2 2 1 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | | _____________________________________________________________________________________________________________________| Page 18 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 6| 7| DAY ON TEST | 2| 2| 8| 2| 2| 0| 4| 2| 2| 2| 0| 0| 9| 2| 2| 2| 2| 2| 3| 2| 2| 8| 2| 6| 2| | 3| 2| 2| 3| 3| 3| 3| 2| 4| 2| 3| 7| 0| 4| 4| 3| 4| 2| 4| 4| 4| 9| 4| 8| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.13% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Angiectasis | 3 | Atrophy | | Degeneration, Fatty | 1 2 1 2 | Hyperplasia | 1 2 2 1 2 | Hypertrophy | 3 | Inflammation, Chronic Active | 1 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 2 1 1 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + M M + + + + + M + + + + + + + + + + + M + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | 1 2 3 3 1 2 3 2 2 2 2 2 1 1 1 2 2 2| Pars Distalis, Hyperplasia | 3 2 2 2 2 3 2 2 2 2 2 2| Pars Intermedia, Cyst | 1 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 1 2 | Follicular Cell, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 | Hyperplasia | 2 2 2 2| Inflammation, Chronic Active | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 4 4 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Cystic | 4| __________________________________________________________________________| Vagina | | Cyst | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 4 | Myelofibrosis | 2 | __________________________________________________________________________| Lymph Node | + + + + + | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 3 | Inflammation, Chronic Active | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 4 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 19 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 6| 7| DAY ON TEST | 2| 2| 8| 2| 2| 0| 4| 2| 2| 2| 0| 0| 9| 2| 2| 2| 2| 2| 3| 2| 2| 8| 2| 6| 2| | 3| 2| 2| 3| 3| 3| 3| 2| 4| 2| 3| 7| 0| 4| 4| 3| 4| 2| 4| 4| 4| 9| 4| 8| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.13% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Fibrosis | | Hematopoietic Cell Proliferation | | Hemorrhage | 4 | Necrosis | 3 | __________________________________________________________________________| Thymus | + + + M + + + + M + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Cystic | 2 1 1 2 2 2 2 2 2 2 2 2 3 2 2 2 3 2 2 1 2| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | | Inflammation, Chronic Active | 4 | Ulcer | 4 | Epidermis, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Hydrocephalus | 3 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Alveolar Epithelium, Hyperplasia | 3 2 | Alveolus, Infiltration Cellular, | | Histiocyte | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2| Artery, Vein, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Perivascular, Infiltration Cellular, | | Lymphocyte | 1 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 2 | Nasolacrimal Duct, Inflammation, | | Suppurative | 2 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | Inflammation, Chronic Active | | Lens, Cataract | | Retina, Degeneration | | __________________________________________________________________________| Harderian Gland | | _____________________________________________________________________________________________________________________| Page 20 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 6| 7| DAY ON TEST | 2| 2| 8| 2| 2| 0| 4| 2| 2| 2| 0| 0| 9| 2| 2| 2| 2| 2| 3| 2| 2| 8| 2| 6| 2| | 3| 2| 2| 3| 3| 3| 3| 2| 4| 2| 3| 7| 0| 4| 4| 3| 4| 2| 4| 4| 4| 9| 4| 8| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.13% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Inflammation, Chronic Active | | __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 1 1 | Nephropathy, Chronic | 2 2 1 2 2 1 2 2 2 1 2 2 2 1 2 2 1 2 1 2 1 1| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 21 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 4| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| | DAY ON TEST | 2| 2| 2| 1| 5| 5| 1| 2| 2| 2| 0| 4| 2| 2| 2| 2| 2| 2| 2| 2| 9| 2| 0| 9| 9| | | 4| 3| 4| 8| 6| 0| 0| 4| 2| 2| 1| 4| 2| 3| 3| 3| 2| 4| 4| 2| 5| 3| 9| 3| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 0.13% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 3.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X | 2 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 1 2.0| Basophilic Focus | X X X X X X X X X X X X X X X X X X X| 38 | Eosinophilic Focus | | 1 | Hepatodiaphragmatic Nodule | X X | 11 | Inflammation, Chronic | 2 1 2 1 1 2 4 2 1 3 2 1 2 2 1 3 2 2 2 2 2 2| 44 2.0| Mixed Cell Focus | X | 1 | Pigmentation, Hemosiderin | 3 1 1 1 1 | 12 1.4| Bile Duct, Hyperplasia | 1 1 1 1 1 4 1 1 1 2 1 1 2 2 2 1| 35 1.4| Hepatocyte, Necrosis | 3 | 3 2.0| Hepatocyte, Vacuolization Cytoplasmic| 2 1 2 3 1 1 2 2 1 2 1 2 2 3 2 2 3 2 1 2 2 2| 46 1.8| Hepatocyte, Centrilobular, | | | Hypertrophy | 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2| 38 2.1| __________________________________________________________________________|____________| Mesentery | + + + + | 7 | Fat, Necrosis | 4 4 4 | 5 4.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 1 | 1 1.0| Acinus, Atrophy | 1 1 1 1 1 2 | 11 1.3| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Basal Cell | 2 | 1 2.0| Epithelium, Hyperplasia | 2 2 | 3 2.3| Epithelium, Inflammation, Chronic | | | Active | 2 | 2 2.5| Epithelium, Ulcer | 4 | 2 4.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 22 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 4| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| | DAY ON TEST | 2| 2| 2| 1| 5| 5| 1| 2| 2| 2| 0| 4| 2| 2| 2| 2| 2| 2| 2| 2| 9| 2| 0| 9| 9| | | 4| 3| 4| 8| 6| 0| 0| 4| 2| 2| 1| 4| 2| 3| 3| 3| 2| 4| 4| 2| 5| 3| 9| 3| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 0.13% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | Cardiomyopathy, Chronic | 2 2 2 1 2 1 2 2 2 2 1 2 2 1 | 27 1.7| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | 2 | 1 2.0| Angiectasis | | 1 3.0| Atrophy | 3 | 1 3.0| Degeneration, Fatty | 1 3 2 1 | 8 1.6| Hyperplasia | 2 1 2 2 1| 10 1.6| Hypertrophy | 1 | 2 2.0| Inflammation, Chronic Active | | 1 1.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 | Hyperplasia | 1 2 1 | 9 1.2| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + M + + + M + + + + M + + + M +| 42 | __________________________________________________________________________|____________| Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Cyst | 2 2 3 3 3 2 3 2 2 3 3 2 2 2 2 2 2 3| 36 2.1| Pars Distalis, Hyperplasia | 2 2 2 3 2 2 2 2 2 2 2 2 3 2| 26 2.2| Pars Intermedia, Cyst | | 1 1.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 2 2 1 2 1 1 2 1 | 11 1.5| Follicular Cell, Hyperplasia | | 1 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 3.0| Hyperplasia | 2 2 3 3 | 8 2.3| Inflammation, Chronic Active | 4 1 | 2 2.5| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 2 4.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Cystic | 3 4 1 | 4 3.0| __________________________________________________________________________|____________| Vagina | + | 1 | Cyst | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 23 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 4| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| | DAY ON TEST | 2| 2| 2| 1| 5| 5| 1| 2| 2| 2| 0| 4| 2| 2| 2| 2| 2| 2| 2| 2| 9| 2| 0| 9| 9| | | 4| 3| 4| 8| 6| 0| 0| 4| 2| 2| 1| 4| 2| 3| 3| 3| 2| 4| 4| 2| 5| 3| 9| 3| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 0.13% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 4 4 3 3 3 | 7 3.6| Myelofibrosis | | 1 2.0| __________________________________________________________________________|____________| Lymph Node | + + + | 8 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | | 1 3.0| Inflammation, Chronic Active | 4 | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | | 1 4.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 2 | 1 2.0| Hematopoietic Cell Proliferation | 3 | 1 3.0| Hemorrhage | | 1 4.0| Necrosis | | 1 3.0| __________________________________________________________________________|____________| Thymus | + + + + + + + M + + + + + + + + + + + + + + + + +| 47 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Cystic | 1 1 2 2 2 3 1 2 2 2 1 2 2 2 2 2 2 2 2 2 2 3| 43 1.9| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperkeratosis | 4 | 1 4.0| Inflammation, Chronic Active | 2 | 2 3.0| Ulcer | | 1 4.0| Epidermis, Hyperplasia | 2 | 2 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 3 3 3| 3 3.0| Hydrocephalus | | 1 3.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 1 | 1 1.0| Alveolar Epithelium, Hyperplasia | 2 2 1 1 | 6 1.8| Alveolus, Infiltration Cellular, | | | Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1| 45 1.1| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 24 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 4| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| | DAY ON TEST | 2| 2| 2| 1| 5| 5| 1| 2| 2| 2| 0| 4| 2| 2| 2| 2| 2| 2| 2| 2| 9| 2| 0| 9| 9| | | 4| 3| 4| 8| 6| 0| 0| 4| 2| 2| 1| 4| 2| 3| 3| 3| 2| 4| 4| 2| 5| 3| 9| 3| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 0.13% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Artery, Vein, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 38 1.0| Perivascular, Infiltration Cellular, | | | Lymphocyte | 1 | 3 1.3| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 2 | 4 2.3| Nasolacrimal Duct, Inflammation, | | | Suppurative | 2 | 3 1.7| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + | 2 | Inflammation, Chronic Active | 3 | 1 3.0| Lens, Cataract | 4 | 1 4.0| Retina, Degeneration | 4 4 | 2 4.0| __________________________________________________________________________|____________| Harderian Gland | + | 1 | Inflammation, Chronic Active | 3 | 1 3.0| __________________________________________________________________________|____________| Zymbal's Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 1 1 1 | 5 1.0| Nephropathy, Chronic | 2 1 2 1 1 2 2 2 1 2 2 2 2 2 2 2 2 2 1 2 2 2| 44 1.7| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 25 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 6| 5| 7| 5| 7| 7| 7| 4| 6| 5| 7| 6| 6| 7| 5| 7| 6| 7| 7| 7| DAY ON TEST | 2| 2| 2| 2| 3| 7| 6| 2| 4| 2| 2| 2| 9| 2| 5| 0| 7| 8| 0| 9| 2| 0| 2| 2| 2| | 3| 3| 3| 4| 3| 5| 1| 4| 8| 3| 4| 2| 1| 6| 0| 8| 4| 2| 8| 0| 4| 5| 2| 2| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.25% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 | Basophilic Focus | X X | Eosinophilic Focus | X X X X X X X X| Hepatodiaphragmatic Nodule | X X | Inflammation, Chronic | 2 2 1 1 2 2 2 2 2 1 1 3 3 2 2 2 1 2| Mixed Cell Focus | X X X X | Pigmentation, Hemosiderin | 2 1 1 1 2 3 2 1 1 2 | Bile Duct, Hyperplasia | 2 1 2 1 2 2 1 1 2 3 3 3 1 1 2 1| Hepatocyte, Degeneration, Cystic | | Hepatocyte, Necrosis | 2 2 | Hepatocyte, Vacuolization Cytoplasmic| 2 2 2 3 2 2 1 2 3 2 1 2 2 2 3 3 2 1 3 2| Hepatocyte, Centrilobular, | | Degeneration | 3 | Hepatocyte, Centrilobular, | | Hypertrophy | 3 3 3 3 2 3 3 3 3 3 4 3 3 3 3 3 3| Portal Vein, Thrombosis | 4 | __________________________________________________________________________| Mesentery | + + + | Fat, Necrosis | 4 4 | __________________________________________________________________________| Oral Mucosa | + + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 1 1 1 2 2 1 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Epithelium, Hyperplasia | 2 3 | Epithelium, Inflammation, Chronic | | Active | 4 | Epithelium, Ulcer | 4 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Epithelium, Erosion | | Epithelium, Ulcer | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 | _____________________________________________________________________________________________________________________| Page 26 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 6| 5| 7| 5| 7| 7| 7| 4| 6| 5| 7| 6| 6| 7| 5| 7| 6| 7| 7| 7| DAY ON TEST | 2| 2| 2| 2| 3| 7| 6| 2| 4| 2| 2| 2| 9| 2| 5| 0| 7| 8| 0| 9| 2| 0| 2| 2| 2| | 3| 3| 3| 4| 3| 5| 1| 4| 8| 3| 4| 2| 1| 6| 0| 8| 4| 2| 8| 0| 4| 5| 2| 2| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.25% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy, Chronic | 1 1 2 1 1 1 2 2| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Fatty | 2 1 1 2 | Hyperplasia | 2 1 2 | Hypertrophy | 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 1 1| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + M + + + + + + + + + M M + + + M + + + + + + + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | 2 2 4 2 2 2 2 4 1 2 3 1 2| Pars Distalis, Hyperplasia | 3 2 3 2 3 2 2 2 3 2 3 1 | Pars Intermedia, Cyst | 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 1 2 1 3 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Hyperplasia | 2 2 2 2 2| Inflammation, Chronic Active | 2 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 | Cyst | | Inflammation, Chronic Active | 3 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Cystic | 1 2 | __________________________________________________________________________| Vagina | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 4 4 4 3 | Myelofibrosis | 2 | __________________________________________________________________________| Lymph Node | + + + + | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 2 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 27 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 6| 5| 7| 5| 7| 7| 7| 4| 6| 5| 7| 6| 6| 7| 5| 7| 6| 7| 7| 7| DAY ON TEST | 2| 2| 2| 2| 3| 7| 6| 2| 4| 2| 2| 2| 9| 2| 5| 0| 7| 8| 0| 9| 2| 0| 2| 2| 2| | 3| 3| 3| 4| 3| 5| 1| 4| 8| 3| 4| 2| 1| 6| 0| 8| 4| 2| 8| 0| 4| 5| 2| 2| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.25% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Hematopoietic Cell Proliferation | 3 3 | __________________________________________________________________________| Thymus | + + + + + + + M + + + + + + + + M + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 4 | Hyperplasia, Cystic | 1 2 1 1 2 2 2 4 1 2 2 2 2 4 2 2 2 2 2 2| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Hemorrhage, | | Acute | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteopetrosis | | __________________________________________________________________________| Skeletal Muscle | | Hemorrhage, Acute | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | __________________________________________________________________________| Peripheral Nerve | | __________________________________________________________________________| Spinal Cord | | Hemorrhage | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 1 | Alveolar Epithelium, Hyperplasia | 1 2 | Alveolus, Infiltration Cellular, | | Histiocyte | 2 1 1 1 1 2 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 2 1 2| Artery, Vein, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Interstitium, Inflammation, Chronic | | Active | 1 | Perivascular, Infiltration Cellular, | | Lymphocyte | 2 2| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 2 | Inflammation, Suppurative | 3 | Nasolacrimal Duct, Inflammation, | | Suppurative | 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | _____________________________________________________________________________________________________________________| Page 28 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 6| 5| 7| 5| 7| 7| 7| 4| 6| 5| 7| 6| 6| 7| 5| 7| 6| 7| 7| 7| DAY ON TEST | 2| 2| 2| 2| 3| 7| 6| 2| 4| 2| 2| 2| 9| 2| 5| 0| 7| 8| 0| 9| 2| 0| 2| 2| 2| | 3| 3| 3| 4| 3| 5| 1| 4| 8| 3| 4| 2| 1| 6| 0| 8| 4| 2| 8| 0| 4| 5| 2| 2| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.25% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Anterior Chamber, Inflammation, | | Suppurative | 3 | Lens, Cataract | | Retina, Degeneration | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Hydronephrosis | 2 | Mineralization | 1 1 1 1 1 1 | Nephropathy, Chronic | 2 2 2 1 2 1 2 2 1 2 2 2 2 1 1 2 2 2 1 2 1 2 2| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 29 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 4| 7| | DAY ON TEST | 2| 2| 9| 2| 7| 2| 1| 2| 0| 2| 7| 2| 2| 2| 2| 0| 4| 2| 2| 2| 2| 0| 2| 8| 2| | | 3| 4| 6| 3| 7| 3| 8| 4| 2| 4| 4| 3| 4| 3| 3| 2| 3| 4| 3| 4| 3| 5| 3| 9| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 0.25% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X | 3 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | 3 | 1 3.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 2 | 3 2.3| Basophilic Focus | X X X X X X X X | 10 | Eosinophilic Focus | X X X X X X X X X X | 18 | Hepatodiaphragmatic Nodule | X X X | 5 | Inflammation, Chronic | 1 2 2 2 2 2 3 2 2 2 2 1 2 2 2 2| 34 1.9| Mixed Cell Focus | X X | 6 | Pigmentation, Hemosiderin | 1 2 2 1 2 2 1 1 1| 19 1.5| Bile Duct, Hyperplasia | 1 1 2 1 1 3 1 1 1 2 1 2 3 3 2 2 1| 33 1.7| Hepatocyte, Degeneration, Cystic | 1 | 1 1.0| Hepatocyte, Necrosis | 2 1 | 4 1.8| Hepatocyte, Vacuolization Cytoplasmic| 2 2 1 2 2 3 2 1 3 3 3 2 2 2 3 2 2 2 2 1 3 2 1 1| 44 2.1| Hepatocyte, Centrilobular, | | | Degeneration | | 1 3.0| Hepatocyte, Centrilobular, | | | Hypertrophy | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 3| 35 3.0| Portal Vein, Thrombosis | | 1 4.0| __________________________________________________________________________|____________| Mesentery | + + + + | 7 | Fat, Necrosis | 4 4 4 4 | 6 4.0| __________________________________________________________________________|____________| Oral Mucosa | | 2 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acinus, Atrophy | 2 1 1 1 1 | 11 1.3| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Epithelium, Hyperplasia | 2 2 | 4 2.3| Epithelium, Inflammation, Chronic | | | Active | 2 | 2 3.0| Epithelium, Ulcer | 2 | 2 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Epithelium, Erosion | 4 | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 30 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 4| 7| | DAY ON TEST | 2| 2| 9| 2| 7| 2| 1| 2| 0| 2| 7| 2| 2| 2| 2| 0| 4| 2| 2| 2| 2| 0| 2| 8| 2| | | 3| 4| 6| 3| 7| 3| 8| 4| 2| 4| 4| 3| 4| 3| 3| 2| 3| 4| 3| 4| 3| 5| 3| 9| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 0.25% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Epithelium, Ulcer | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 3.0| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy, Chronic | 2 2 2 2 2 2 2 2 1 1 2 1 1| 21 1.6| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Fatty | 2 1 | 6 1.5| Hyperplasia | 2 1 1 1 1| 8 1.4| Hypertrophy | 2 4 | 3 2.7| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 1 2 | 7 1.1| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + M + + + + + + + + M + + M + + + M + M M + + +| 39 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Cyst | 2 2 1 2 2 1 3 2 2 2 1 3 3 1 1| 28 2.0| Pars Distalis, Hyperplasia | 2 3 2 2 2 3 3 3 2 | 21 2.4| Pars Intermedia, Cyst | | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | | 5 1.6| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 3 3 | 2 3.0| Hyperplasia | 2 2 2 3 3 | 10 2.2| Inflammation, Chronic Active | 1 2 | 3 1.7| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 | Atrophy | | 1 3.0| Cyst | 2 | 1 2.0| Inflammation, Chronic Active | | 1 3.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 | Hyperplasia, Cystic | 3 | 3 2.0| __________________________________________________________________________|____________| Vagina | + + | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 31 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 4| 7| | DAY ON TEST | 2| 2| 9| 2| 7| 2| 1| 2| 0| 2| 7| 2| 2| 2| 2| 0| 4| 2| 2| 2| 2| 0| 2| 8| 2| | | 3| 4| 6| 3| 7| 3| 8| 4| 2| 4| 4| 3| 4| 3| 3| 2| 3| 4| 3| 4| 3| 5| 3| 9| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 0.25% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 3 | 7 3.3| Myelofibrosis | | 1 2.0| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + | 12 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 | Ectasia | 2 | 3 2.3| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | | 2 3.0| __________________________________________________________________________|____________| Thymus | + + + M + + M + + + + + + + + + + + + + + + + + +| 46 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 4.0| Hyperplasia, Cystic | 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 | 37 2.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Hemorrhage, | | | Acute | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteopetrosis | 1 | 1 1.0| __________________________________________________________________________|____________| Skeletal Muscle | + + | 2 | Hemorrhage, Acute | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 3 | 1 3.0| __________________________________________________________________________|____________| Peripheral Nerve | + | 1 | __________________________________________________________________________|____________| Spinal Cord | + + | 2 | Hemorrhage | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 1 | 3 1.3| Alveolar Epithelium, Hyperplasia | | 2 1.5| Alveolus, Infiltration Cellular, | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 32 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 4| 7| | DAY ON TEST | 2| 2| 9| 2| 7| 2| 1| 2| 0| 2| 7| 2| 2| 2| 2| 0| 4| 2| 2| 2| 2| 0| 2| 8| 2| | | 3| 4| 6| 3| 7| 3| 8| 4| 2| 4| 4| 3| 4| 3| 3| 2| 3| 4| 3| 4| 3| 5| 3| 9| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 0.25% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Histiocyte | 2 2 1 2 2 1 1 2 1 2 2 2 1 1 1 2 1 1 2 1 1| 46 1.3| Artery, Vein, Mineralization | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 44 1.0| Interstitium, Inflammation, Chronic | | | Active | | 1 1.0| Perivascular, Infiltration Cellular, | | | Lymphocyte | 1 1 1 | 5 1.4| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 2 2| 5 2.0| Inflammation, Suppurative | | 1 3.0| Nasolacrimal Duct, Inflammation, | | | Suppurative | 2 2 2 | 4 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 2 | Anterior Chamber, Inflammation, | | | Suppurative | | 1 3.0| Lens, Cataract | 4 | 1 4.0| Retina, Degeneration | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 4 | 1 4.0| Hydronephrosis | | 1 2.0| Mineralization | 1 1 | 8 1.0| Nephropathy, Chronic | 2 2 1 1 2 2 1 2 1 2 2 2 2 1 2 2 2 2 2 2| 43 1.7| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 33 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 _____________________________________________________________________________________________________________________ | 6| 7| 6| 6| 5| 6| 5| 7| 5| 5| 5| 7| 4| 2| 6| 6| 5| 6| 7| 5| 7| 5| 7| 5| 7| DAY ON TEST | 6| 2| 9| 2| 0| 9| 8| 2| 8| 6| 6| 2| 6| 8| 4| 6| 0| 9| 0| 7| 2| 9| 2| 7| 2| | 7| 3| 2| 7| 9| 8| 3| 3| 5| 8| 0| 3| 3| 1| 1| 2| 5| 7| 4| 5| 3| 1| 3| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X X X | Eosinophilic Focus | X | Hepatodiaphragmatic Nodule | X X | Inflammation, Chronic | 1 1 1 2 1 1 1 1 2 | Pigmentation, Hemosiderin | 1 1 1 1 2 1 1 1 1 1| Bile Duct, Hyperplasia | 3 2 2 3 2 2 3 2 2 3 1 2 2 1 3 3 3 2 3 2 2 2 2 3| Hepatocyte, Degeneration, Cystic | 2 1 1 2 2 1 1 | Hepatocyte, Necrosis | 2 2 2 3 2 | Hepatocyte, Vacuolization Cytoplasmic| 2 2 2 1 2 1 1 2 2 2 2 3 2 | Portal Vein, Thrombosis | | __________________________________________________________________________| Mesentery | + + + + + + + + +| Fat, Necrosis | 4 4 4 4 | Fat, Pigmentation, Hemosiderin | 4| __________________________________________________________________________| Oral Mucosa | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 1 1 1 1 2 1 1 3 1 3 1 2 3| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Epithelium, Hyperplasia | 2 2 | Epithelium, Inflammation, Chronic | | Active | 2 | Epithelium, Ulcer | 4 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Epithelium, Erosion | 2 | Epithelium, Inflammation, Chronic | | Active | 2 2 | Epithelium, Ulcer | 4 4 4 4 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy, Chronic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 3 2 2 2 | Pigmentation, Hemosiderin | 1 | Atrium, Thrombosis | 4 | _____________________________________________________________________________________________________________________| Page 34 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 _____________________________________________________________________________________________________________________ | 6| 7| 6| 6| 5| 6| 5| 7| 5| 5| 5| 7| 4| 2| 6| 6| 5| 6| 7| 5| 7| 5| 7| 5| 7| DAY ON TEST | 6| 2| 9| 2| 0| 9| 8| 2| 8| 6| 6| 2| 6| 8| 4| 6| 0| 9| 0| 7| 2| 9| 2| 7| 2| | 7| 3| 2| 7| 9| 8| 3| 3| 5| 8| 0| 3| 3| 1| 1| 2| 5| 7| 4| 5| 3| 1| 3| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Fatty | 2 1 2 2 3 1 2 2 1 2 1| Hyperplasia | 1 2 2 2 2 1 2 1 1| Hypertrophy | 2 1 | Inflammation, Chronic Active | 2 | Thrombosis | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 1 1 1 2 1 2 | Necrosis | 4 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + M + + +| Hyperplasia | 2 2 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| Pars Distalis, Cyst | | Pars Distalis, Hyperplasia | 2 2 2 2 2 2 2 2 | Pars Intermedia, Cyst | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 1 1 | Follicle, Cyst | 2 | Follicular Cell, Hyperplasia, Cystic | | Follicular Cell, Hyperplasia | 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Coagulating Gland | + | Inflammation, Chronic Active | 4 | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 4 | Hyperplasia | 2 2 2 | Inflammation, Chronic Active | 2 2 2 1 2 1 2 2 2 2 2 3 1 2 2 2 2 3 2 2 2 2| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 2 1 1 2 2 1 2 2 1 4 3 2 2 2 2 1 3 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Germinal Epithelium, Degeneration | | Interstitial Cell, Hyperplasia | 1 1 1 2 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 35 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 _____________________________________________________________________________________________________________________ | 6| 7| 6| 6| 5| 6| 5| 7| 5| 5| 5| 7| 4| 2| 6| 6| 5| 6| 7| 5| 7| 5| 7| 5| 7| DAY ON TEST | 6| 2| 9| 2| 0| 9| 8| 2| 8| 6| 6| 2| 6| 8| 4| 6| 0| 9| 0| 7| 2| 9| 2| 7| 2| | 7| 3| 2| 7| 9| 8| 3| 3| 5| 8| 0| 3| 3| 1| 1| 2| 5| 7| 4| 5| 3| 1| 3| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Atrophy | 3| Hyperplasia | 4 3 3 4 4 3 3 4 4 4 3 3 3 4 4 3 3 3 | Myelofibrosis | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Fibrosis | 3 2 1 3 3 | Hyperplasia, Lymphoid | 3 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| Cyst | 3 | Hyperplasia, Cystic | 1 2 2 2 2 1 2 3 4 1 3 2 2| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 | Epidermis, Hyperplasia | 1 | Sebaceous Gland, Hyperplasia | 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3 3 3 | __________________________________________________________________________| Peripheral Nerve | | __________________________________________________________________________| Spinal Cord | | Demyelination | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Metaplasia, Osseous | 1 | Alveolar Epithelium, Hyperplasia | 2 2 2 2 | Alveolus, Infiltration Cellular, | | Histiocyte | 1 1 1 1 1 1 1 1| Artery, Vein, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Perivascular, Infiltration Cellular, | | Lymphocyte | 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 36 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 _____________________________________________________________________________________________________________________ | 6| 7| 6| 6| 5| 6| 5| 7| 5| 5| 5| 7| 4| 2| 6| 6| 5| 6| 7| 5| 7| 5| 7| 5| 7| DAY ON TEST | 6| 2| 9| 2| 0| 9| 8| 2| 8| 6| 6| 2| 6| 8| 4| 6| 0| 9| 0| 7| 2| 9| 2| 7| 2| | 7| 3| 2| 7| 9| 8| 3| 3| 5| 8| 0| 3| 3| 1| 1| 2| 5| 7| 4| 5| 3| 1| 3| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Inflammation, Chronic Active | 2 2 2 | Inflammation, Suppurative | 3 2 | Arteriole, Venule, Thrombosis | 3 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 3 | Infarct | 2 | Nephropathy, Chronic | 2 2 2 2 2 2 3 2 2 2 2 2 2 1 2 2 2 3 3 2 3 2 3 2 2| Papilla, Hyperplasia, Atypical | | Renal Tubule, Hyperplasia | 1| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3 | _____________________________________________________________________________________________________________________| Page 37 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 6| 6| 6| 5| 7| 6| 6| 6| 7| 7| 7| 6| 4| 3| 7| 6| 7| 6| 7| 6| | DAY ON TEST | 2| 2| 2| 4| 1| 7| 1| 7| 2| 2| 6| 6| 5| 1| 1| 2| 4| 5| 0| 1| 8| 2| 5| 2| 5| | | 3| 3| 3| 5| 0| 6| 9| 4| 6| 3| 9| 9| 5| 0| 5| 3| 6| 7| 5| 9| 3| 3| 5| 3| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X | 3 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X X X X | 14 | Eosinophilic Focus | | 1 | Hepatodiaphragmatic Nodule | X | 3 | Inflammation, Chronic | 2 1 1 2 1 1 2 2 1 | 18 1.3| Pigmentation, Hemosiderin | 1 2 2 2 1 1 1 2 1 | 19 1.3| Bile Duct, Hyperplasia | 2 2 3 3 3 3 3 3 1 2 3 3 1 3 2 1 2 3 3 2 2 2 2| 47 2.3| Hepatocyte, Degeneration, Cystic | 4 1 2 2 2 1 3 1 1 | 16 1.7| Hepatocyte, Necrosis | 3 1 1 2 1 | 10 1.9| Hepatocyte, Vacuolization Cytoplasmic| 1 1 2 1 2 2 1 2 1 1 2 1 1 | 26 1.6| Portal Vein, Thrombosis | 4 | 1 4.0| __________________________________________________________________________|____________| Mesentery | + + | 11 | Fat, Necrosis | 4 4 | 6 4.0| Fat, Pigmentation, Hemosiderin | | 1 4.0| __________________________________________________________________________|____________| Oral Mucosa | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acinus, Atrophy | 1 2 2 2 2 1 1 1 2 1 1 2 | 25 1.6| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Epithelium, Hyperplasia | 2 2 | 4 2.0| Epithelium, Inflammation, Chronic | | | Active | 3 | 2 2.5| Epithelium, Ulcer | 4 | 2 4.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Epithelium, Erosion | 2 | 2 2.0| Epithelium, Inflammation, Chronic | | | Active | | 2 2.0| Epithelium, Ulcer | | 4 4.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 38 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 6| 6| 6| 5| 7| 6| 6| 6| 7| 7| 7| 6| 4| 3| 7| 6| 7| 6| 7| 6| | DAY ON TEST | 2| 2| 2| 4| 1| 7| 1| 7| 2| 2| 6| 6| 5| 1| 1| 2| 4| 5| 0| 1| 8| 2| 5| 2| 5| | | 3| 3| 3| 5| 0| 6| 9| 4| 6| 3| 9| 9| 5| 0| 5| 3| 6| 7| 5| 9| 3| 3| 5| 3| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | Inflammation, Chronic Active | | 1 3.0| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy, Chronic | 2 1 2 2 2 2 1 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2| 42 2.0| Pigmentation, Hemosiderin | | 1 1.0| Atrium, Thrombosis | 4 | 2 4.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Fatty | 1 1 2 2 1 2 1 2 1 2 1 1 1 1 1| 26 1.5| Hyperplasia | 1 2 1 2 2 2 1 1 | 17 1.5| Hypertrophy | 2 | 3 1.7| Inflammation, Chronic Active | | 1 2.0| Thrombosis | 2 | 1 2.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 1 3 1 2 2 2 2 1 1 1 2| 19 1.6| Necrosis | | 1 4.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + M + + + + + + M M + + + + +| 45 | Hyperplasia | | 2 2.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Cyst | 2 | 1 2.0| Pars Distalis, Hyperplasia | 2 2 1 2 2 2 2 3 2 | 17 2.0| Pars Intermedia, Cyst | 2 | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 2 2 1 2 2 1 2 2 | 11 1.6| Follicle, Cyst | | 1 2.0| Follicular Cell, Hyperplasia, Cystic | 2 | 1 2.0| Follicular Cell, Hyperplasia | | 1 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Coagulating Gland | + | 2 | Inflammation, Chronic Active | | 1 4.0| __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 2 3.5| Hyperplasia | 2 3 | 5 2.2| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 39 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 6| 6| 6| 5| 7| 6| 6| 6| 7| 7| 7| 6| 4| 3| 7| 6| 7| 6| 7| 6| | DAY ON TEST | 2| 2| 2| 4| 1| 7| 1| 7| 2| 2| 6| 6| 5| 1| 1| 2| 4| 5| 0| 1| 8| 2| 5| 2| 5| | | 3| 3| 3| 5| 0| 6| 9| 4| 6| 3| 9| 9| 5| 0| 5| 3| 6| 7| 5| 9| 3| 3| 5| 3| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Inflammation, Chronic Active | 3 3 2 2 2 1 2 2 2 3 2 1 1 2 2 2 1 1 1 1 2 2 2 1 2| 47 1.9| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 3 1 1 2 1 2 2 1 1 2 2 2 3 2 2 1 1 2 2 | 37 1.8| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Germinal Epithelium, Degeneration | 4 4 | 2 4.0| Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 | 11 1.1| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 3.0| Hyperplasia | 4 4 4 3 4 4 4 4 3 4 4 4 4 3 3 4 4 3 3 4| 38 3.6| Myelofibrosis | 2 2 | 2 2.0| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + | 24 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 2 | 2 2.5| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 3 | 1 3.0| Fibrosis | 1 2 2 1 | 9 2.0| Hyperplasia, Lymphoid | | 1 3.0| __________________________________________________________________________|____________| Thymus | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 48 | Cyst | | 1 3.0| Hyperplasia, Cystic | 2 2 2 2 2 1 2 1 2 2 2 2 3 2 2 | 28 2.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 3 | 2 3.0| Epidermis, Hyperplasia | | 1 1.0| Sebaceous Gland, Hyperplasia | | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 2 | 4 2.8| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 40 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 6| 6| 6| 5| 7| 6| 6| 6| 7| 7| 7| 6| 4| 3| 7| 6| 7| 6| 7| 6| | DAY ON TEST | 2| 2| 2| 4| 1| 7| 1| 7| 2| 2| 6| 6| 5| 1| 1| 2| 4| 5| 0| 1| 8| 2| 5| 2| 5| | | 3| 3| 3| 5| 0| 6| 9| 4| 6| 3| 9| 9| 5| 0| 5| 3| 6| 7| 5| 9| 3| 3| 5| 3| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Peripheral Nerve | + | 1 | __________________________________________________________________________|____________| Spinal Cord | + | 1 | Demyelination | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 2 | 2 2.0| Metaplasia, Osseous | | 1 1.0| Alveolar Epithelium, Hyperplasia | 2 2 | 6 2.0| Alveolus, Infiltration Cellular, | | | Histiocyte | 1 1 1 1 1 1 1 1 1 1| 18 1.0| Artery, Vein, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 46 1.0| Perivascular, Infiltration Cellular, | | | Lymphocyte | | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 3 3 3 2 | 8 2.4| Inflammation, Suppurative | 2 2 3 2 | 6 2.3| Arteriole, Venule, Thrombosis | | 1 3.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 2 3.0| Infarct | | 1 2.0| Nephropathy, Chronic | 2 2 2 2 2 2 3 2 2 3 2 2 2 3 3 3 3 2 2 3 2 2 2 2| 49 2.2| Papilla, Hyperplasia, Atypical | 2 | 1 2.0| Renal Tubule, Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 41 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 6| 5| 6| 6| 5| 5| 6| 7| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| DAY ON TEST | 6| 2| 2| 1| 6| 0| 4| 4| 7| 6| 3| 0| 1| 2| 8| 1| 5| 9| 4| 9| 6| 6| 3| 0| 7| | 9| 3| 3| 2| 9| 2| 1| 1| 9| 2| 4| 9| 9| 3| 3| 0| 2| 4| 2| 7| 1| 9| 5| 9| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.06% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 | Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 | Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | | Inflammation, Suppurative | | Mineralization | 2 | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X | Eosinophilic Focus | X X X | Hepatodiaphragmatic Nodule | X | Inflammation, Chronic | 1 2 1 1 1 1 1 1 | Mixed Cell Focus | X | Pigmentation, Hemosiderin | 1 1 2 1 2 2 1 2 | Bile Duct, Hyperplasia | 3 1 2 2 2 3 3 3 3 1 3 3 3 2 2 3 2 1 2 2 2 1 2 2 2| Hepatocyte, Degeneration, Cystic | 3 2 2 1 2 1 1 2 1 2 1 2 1 1 3 1| Hepatocyte, Necrosis | 2 1 2 2 3 1 | Hepatocyte, Vacuolization Cytoplasmic| 1 2 2 1 1 3 1 1 1 2 3 2| Hepatocyte, Centrilobular, | | Degeneration | | Hepatocyte, Centrilobular, | | Hypertrophy | 1 2 1 2 1 1 1| __________________________________________________________________________| Mesentery | + + | Fat, Necrosis | 4 4 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 | Acinus, Atrophy | 1 2 2 2 2 2 | Artery, Inflammation, Chronic Active | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 3 3| Perforation | X | Epithelium, Hyperplasia | 2 2 2 2 2 | Epithelium, Inflammation, Chronic | | Active | 2 4 4 3 | Epithelium, Ulcer | 4 4 4 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 42 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 6| 5| 6| 6| 5| 5| 6| 7| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| DAY ON TEST | 6| 2| 2| 1| 6| 0| 4| 4| 7| 6| 3| 0| 1| 2| 8| 1| 5| 9| 4| 9| 6| 6| 3| 0| 7| | 9| 3| 3| 2| 9| 2| 1| 1| 9| 2| 4| 9| 9| 3| 3| 0| 2| 4| 2| 7| 1| 9| 5| 9| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.06% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Mineralization | 3 2 2| Epithelium, Erosion | 3 | Epithelium, Inflammation, Chronic | | Active | 1 | Epithelium, Necrosis | 3 | Epithelium, Ulcer | 3 | __________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Aorta, Mineralization | 3 2 4| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy, Chronic | 2 2 2 2 2 1 2 2 2 3 2 2 2 2 2 3 2 2 2 3 3 2 3 3| Mineralization | 1 3 2| Atrium, Thrombosis | 2 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | 2| Degeneration, Fatty | 2 1 1 1 2 2 2 2 2 2 | Hyperplasia | 1 2 | Hypertrophy | 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 4 | Hyperplasia | 3 1 1 2 2 2 2 2 2| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + M M + + + + + + + + + + + + + + + + +| Hyperplasia | 4 2 2 2 4 4 3| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | 1 3 1 1 2 | Pars Distalis, Hyperplasia | 2 1 3 2 2 2 3 2 2 2 | Pars Intermedia, Cyst | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 1 1 | Follicle, Cyst | 3 2 | Follicular Cell, Hyperplasia, Cystic | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | | __________________________________________________________________________| Tissue NOS | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Coagulating Gland | | Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| Page 43 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 6| 5| 6| 6| 5| 5| 6| 7| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| DAY ON TEST | 6| 2| 2| 1| 6| 0| 4| 4| 7| 6| 3| 0| 1| 2| 8| 1| 5| 9| 4| 9| 6| 6| 3| 0| 7| | 9| 3| 3| 2| 9| 2| 1| 1| 9| 2| 4| 9| 9| 3| 3| 0| 2| 4| 2| 7| 1| 9| 5| 9| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.06% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | 4 2 | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | Hyperplasia | 3 4 4 2 2 | Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 1 2 3 2 2 3 2 2 2 2 2 2 4 2 2| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 2 3 1 3 2 1 1 1 3 2 2 1 4 2 1 2| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Germinal Epithelium, Degeneration | 3 | Interstitial Cell, Hyperplasia | 2 1 1 2 1 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Hyperplasia | 4 3 3 2 4 4 4 4 3 4 4 4 3 3 3 4 4 4 4 | Inflammation, Suppurative | 2 | Myelofibrosis | 2 | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 2 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 3 2 2 2 4 3 4| Hematopoietic Cell Proliferation | | Metaplasia, Lipocyte | 4 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + M M + + + M| Cyst | 2 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| Cyst | 3 | Hyperplasia, Cystic | 2 2 2 2 2 1 2 1 2 3 2 3 1 2 | Mineralization | 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | | Inflammation, Chronic Active | 2 | Epidermis, Hyperplasia | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 44 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 6| 5| 6| 6| 5| 5| 6| 7| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| DAY ON TEST | 6| 2| 2| 1| 6| 0| 4| 4| 7| 6| 3| 0| 1| 2| 8| 1| 5| 9| 4| 9| 6| 6| 3| 0| 7| | 9| 3| 3| 2| 9| 2| 1| 1| 9| 2| 4| 9| 9| 3| 3| 0| 2| 4| 2| 7| 1| 9| 5| 9| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.06% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | Fibrous Osteodystrophy | 2 2 2 4 4 4| Osteopetrosis | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3 | __________________________________________________________________________| Peripheral Nerve | + | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Metaplasia, Osseous | 1 | Alveolar Epithelium, Hyperplasia | 1 | Alveolus, Infiltration Cellular, | | Histiocyte | 1 1 1 1 1 1 1 1 | Artery, Thrombosis | | Artery, Vein, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3 1 1 1 1| Interstitium, Mineralization | 3 2| Perivascular, Infiltration Cellular, | | Lymphocyte | 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 3 4 2 2 4| Inflammation, Suppurative | 3 2 | Arteriole, Venule, Thrombosis | 4 4 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 4 | Inflammation, Suppurative | 3 | Nephropathy, Chronic | 3 3 2 4 3 2 2 3 3 3 2 3 2 3 2 2 3 4 2 4 4 4 2 2 4| Renal Tubule, Hyperplasia | 3 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 2| _____________________________________________________________________________________________________________________| Page 45 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 3| 6| 5| 7| 7| 5| 6| 6| 7| 6| 6| 5| 7| 7| 5| 6| 6| 6| 5| 6| 5| 7| | DAY ON TEST | 1| 2| 2| 3| 5| 0| 2| 1| 4| 9| 3| 0| 1| 2| 2| 0| 1| 4| 8| 7| 7| 8| 7| 0| 2| | | 5| 3| 3| 0| 4| 2| 3| 0| 4| 7| 5| 9| 9| 7| 6| 3| 2| 2| 3| 3| 4| 3| 4| 3| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 0.06% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | | 1 2.0| Parasite Metazoan | X | 2 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | | 1 2.0| Parasite Metazoan | X X | 3 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Erosion | 2 3 | 2 2.5| Inflammation, Suppurative | 2 2 | 2 2.0| Mineralization | | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X X| 9 | Eosinophilic Focus | X 3 3 | 6 3.0| Hepatodiaphragmatic Nodule | X | 2 | Inflammation, Chronic | 1 1 1 1 2 1 1 2 1 1 1| 19 1.2| Mixed Cell Focus | X | 2 | Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 1 1 1 | 18 1.2| Bile Duct, Hyperplasia | 2 3 2 2 2 2 2 3 1 1 1 3 1 3 1 3 2 3 3 2 2 3 2 3 2| 50 2.2| Hepatocyte, Degeneration, Cystic | 2 2 1 1 3 2 1 2 1 2 1| 27 1.6| Hepatocyte, Necrosis | 2 3 1 2 1 2 | 12 1.8| Hepatocyte, Vacuolization Cytoplasmic| 2 2 2 1 2 2 1 3 2 1 1 1 1 2 2 2| 28 1.7| Hepatocyte, Centrilobular, | | | Degeneration | 2 | 1 2.0| Hepatocyte, Centrilobular, | | | Hypertrophy | 1 2 2 1 2 1 2| 14 1.4| __________________________________________________________________________|____________| Mesentery | + + + +| 6 | Fat, Necrosis | 4| 3 4.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 1.0| Acinus, Atrophy | 1 1 2 2 1 1 1 1 | 14 1.5| Artery, Inflammation, Chronic Active | 4| 1 4.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 3 | 3 3.0| Perforation | X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 46 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 3| 6| 5| 7| 7| 5| 6| 6| 7| 6| 6| 5| 7| 7| 5| 6| 6| 6| 5| 6| 5| 7| | DAY ON TEST | 1| 2| 2| 3| 5| 0| 2| 1| 4| 9| 3| 0| 1| 2| 2| 0| 1| 4| 8| 7| 7| 8| 7| 0| 2| | | 5| 3| 3| 0| 4| 2| 3| 0| 4| 7| 5| 9| 9| 7| 6| 3| 2| 2| 3| 3| 4| 3| 4| 3| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 0.06% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Epithelium, Hyperplasia | 2 3 3 2 2 2 | 11 2.2| Epithelium, Inflammation, Chronic | | | Active | 4 3 3 4 3 1 | 10 3.1| Epithelium, Ulcer | 4 4 4 4 | 7 4.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 2 3 2 | 6 2.3| Epithelium, Erosion | | 1 3.0| Epithelium, Inflammation, Chronic | | | Active | | 1 1.0| Epithelium, Necrosis | | 1 3.0| Epithelium, Ulcer | | 1 3.0| __________________________________________________________________________|____________| Tooth | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Aorta, Mineralization | 2 4 | 5 3.0| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy, Chronic | 3 2 2 2 3 2 2 1 2 2 2 1 2 2 2 2 2 2 2 2 2| 45 2.1| Mineralization | 3 | 4 2.3| Atrium, Thrombosis | 3 | 3 2.3| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | 2| 2 2.0| Degeneration, Fatty | 2 2 3 2 2 2 1 1 | 18 1.8| Hyperplasia | 1 1 | 4 1.3| Hypertrophy | 2 | 2 2.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 1 4.0| Hyperplasia | 2 1 2 1 2 1 1 2 1 4 4 2 1| 22 1.9| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + M + + + + + + + M + + M M + + M + M M| 41 | Hyperplasia | 4 2 4 3 3 3 2 2 3 | 16 2.9| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Cyst | 1 2 | 7 1.6| Pars Distalis, Hyperplasia | 2 2 1 2 2 2 2 2 | 18 2.0| Pars Intermedia, Cyst | 1 2 | 2 1.5| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 1 1 1 1 1 1 1 2 | 11 1.1| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 47 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 3| 6| 5| 7| 7| 5| 6| 6| 7| 6| 6| 5| 7| 7| 5| 6| 6| 6| 5| 6| 5| 7| | DAY ON TEST | 1| 2| 2| 3| 5| 0| 2| 1| 4| 9| 3| 0| 1| 2| 2| 0| 1| 4| 8| 7| 7| 8| 7| 0| 2| | | 5| 3| 3| 0| 4| 2| 3| 0| 4| 7| 5| 9| 9| 7| 6| 3| 2| 2| 3| 3| 4| 3| 4| 3| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 0.06% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Follicle, Cyst | 2 | 3 2.3| Follicular Cell, Hyperplasia, Cystic | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Peritoneum | + | 1 | __________________________________________________________________________|____________| Tissue NOS | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Coagulating Gland | + | 1 | Inflammation, Chronic Active | 4 | 1 4.0| __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granuloma Sperm | 2 | 3 2.7| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 2.0| Hyperplasia | 4 3 | 7 3.1| Inflammation, Chronic Active | 1 2 2 2 3 2 2 2 2 3 1 2 2 2 1 2 2 1 2 1 2 1 2| 47 2.0| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 3 1 1 2 2 1 3 2 2 3 1 1 2 2 1 2 2| 34 1.9| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 2 | 1 2.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Germinal Epithelium, Degeneration | 2 | 2 2.5| Interstitial Cell, Hyperplasia | 2 1 1 1 1 | 11 1.3| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 3 | 1 3.0| Hyperplasia | 3 3 4 4 3 4 4 4 4 4 4 3 3 3 4 3| 35 3.6| Inflammation, Suppurative | | 1 2.0| Myelofibrosis | | 1 2.0| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + | 23 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 3 | 3 2.7| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 2 | 2 2.5| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 2 2 2 1 1 3 3 3 3 2 3 3 | 19 2.5| Hematopoietic Cell Proliferation | 2 3 | 2 2.5| Metaplasia, Lipocyte | | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 48 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 3| 6| 5| 7| 7| 5| 6| 6| 7| 6| 6| 5| 7| 7| 5| 6| 6| 6| 5| 6| 5| 7| | DAY ON TEST | 1| 2| 2| 3| 5| 0| 2| 1| 4| 9| 3| 0| 1| 2| 2| 0| 1| 4| 8| 7| 7| 8| 7| 0| 2| | | 5| 3| 3| 0| 4| 2| 3| 0| 4| 7| 5| 9| 9| 7| 6| 3| 2| 2| 3| 3| 4| 3| 4| 3| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 0.06% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Cyst | | 2 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cyst | | 1 3.0| Hyperplasia, Cystic | 1 1 2 2 2 3 2 2 2 3 2 | 25 2.0| Mineralization | | 1 2.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperkeratosis | 3 | 1 3.0| Inflammation, Chronic Active | | 1 2.0| Epidermis, Hyperplasia | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | 3 4 2 4 | 10 3.1| Osteopetrosis | 2 2 | 2 2.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 4 | 2 3.5| __________________________________________________________________________|____________| Peripheral Nerve | | 1 | __________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Metaplasia, Osseous | | 1 1.0| Alveolar Epithelium, Hyperplasia | | 1 1.0| Alveolus, Infiltration Cellular, | | | Histiocyte | 1 1 1 1 1 1 1 1 1 1| 18 1.0| Artery, Thrombosis | 2 | 1 2.0| Artery, Vein, Mineralization | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 42 1.1| Interstitium, Mineralization | 2 | 3 2.3| Perivascular, Infiltration Cellular, | | | Lymphocyte | | 1 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 3 3 1 3 2 | 12 2.6| Inflammation, Suppurative | 2 2 3 3 3 | 7 2.6| Arteriole, Venule, Thrombosis | | 2 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 49 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 3| 6| 5| 7| 7| 5| 6| 6| 7| 6| 6| 5| 7| 7| 5| 6| 6| 6| 5| 6| 5| 7| | DAY ON TEST | 1| 2| 2| 3| 5| 0| 2| 1| 4| 9| 3| 0| 1| 2| 2| 0| 1| 4| 8| 7| 7| 8| 7| 0| 2| | | 5| 3| 3| 0| 4| 2| 3| 0| 4| 7| 5| 9| 9| 7| 6| 3| 2| 2| 3| 3| 4| 3| 4| 3| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 0.06% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | __________________________________________________________________________|____________| Zymbal's Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 2 | 2 3.0| Inflammation, Suppurative | | 1 3.0| Nephropathy, Chronic | 4 3 3 2 4 2 2 3 4 3 3 3 2 2 4 3 3 2 4 3 4 2 3| 48 2.9| Renal Tubule, Hyperplasia | 3 | 2 3.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 50 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 _____________________________________________________________________________________________________________________ | 5| 5| 6| 5| 6| 6| 6| 6| 6| 7| 6| 6| 5| 5| 5| 5| 6| 6| 6| 5| 6| 5| 6| 7| 3| DAY ON TEST | 2| 8| 4| 7| 1| 9| 8| 6| 6| 2| 3| 4| 6| 5| 8| 5| 8| 5| 1| 7| 3| 9| 4| 1| 5| | 9| 9| 1| 6| 9| 1| 3| 7| 8| 3| 2| 1| 2| 8| 5| 1| 3| 5| 3| 2| 5| 9| 8| 2| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.13% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Ulcer | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | 4 | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X | Clear Cell Focus | | Eosinophilic Focus | X X | Hepatodiaphragmatic Nodule | X | Inflammation, Chronic | 1 1 2 1 1 2 1 1 2 2 | Pigmentation, Hemosiderin | 2 1 1 1 1 1 1 | Bile Duct, Hyperplasia | 2 3 2 2 1 1 1 3 2 1 2 3 3 3 3 2 1 2 1 2 1 2 2 2 3| Hepatocyte, Degeneration, Cystic | 1 3 2 2 2 2 1 1 1 2 2 1 2 | Hepatocyte, Necrosis | 2 2 | Hepatocyte, Vacuolization Cytoplasmic| 3 2 2 2 2 2 1 3 2 1 1 2 2 | Hepatocyte, Centrilobular, | | Hypertrophy | 1 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | __________________________________________________________________________| Mesentery | + + + + | Hemorrhage | 4 | Inflammation, Chronic Active | 3 | Fat, Inflammation, Chronic Active | 3 | Fat, Mineralization | | Fat, Necrosis | | Fat, Pigmentation, Hematoidin | | Fat, Pigmentation, Hemosiderin | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 1 1 1 1 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 | Mineralization | 3 | Perforation | X | Epithelium, Hyperplasia | 2 3 3 2 2 2 2 2 2 2 | Epithelium, Inflammation, Chronic | | Active | 4 3 4 3 3 3 2 3 4 1| Epithelium, Ulcer | 4 4 4 4 4 4 2 4 4 4| _____________________________________________________________________________________________________________________| Page 51 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 _____________________________________________________________________________________________________________________ | 5| 5| 6| 5| 6| 6| 6| 6| 6| 7| 6| 6| 5| 5| 5| 5| 6| 6| 6| 5| 6| 5| 6| 7| 3| DAY ON TEST | 2| 8| 4| 7| 1| 9| 8| 6| 6| 2| 3| 4| 6| 5| 8| 5| 8| 5| 1| 7| 3| 9| 4| 1| 5| | 9| 9| 1| 6| 9| 1| 3| 7| 8| 3| 2| 1| 2| 8| 5| 1| 3| 5| 3| 2| 5| 9| 8| 2| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.13% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 1 2 3 2 2 2 | Epithelium, Inflammation, Chronic | | Active | | Epithelium, Necrosis | 2 | __________________________________________________________________________| Tongue | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Aorta, Mineralization | 1 3 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy, Chronic | 1 2 2 2 3 1 1 3 2 2 2 2 2 2 2 2 2 2 2 2 2 | Mineralization | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | | Atrophy | 3 | Degeneration, Fatty | 2 4 1 3 2 1 2 2 1 | Hyperplasia | 1 2 1 1 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 2 2 1 3 1 1 2 2 2 2 1 2 1 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 2 3 2 3 3 3 3 3 3 3 3 3 3 2 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | 3 | Pars Distalis, Hyperplasia | 2 2 1 2 1 1 1 2 2 | Pars Intermedia, Cyst | 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 | Follicle, Cyst | | Follicle, Hyperplasia, Cystic | 2 | Follicular Cell, Hyperplasia, Cystic | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 4 3 | Hyperplasia | 1 | _____________________________________________________________________________________________________________________| Page 52 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 _____________________________________________________________________________________________________________________ | 5| 5| 6| 5| 6| 6| 6| 6| 6| 7| 6| 6| 5| 5| 5| 5| 6| 6| 6| 5| 6| 5| 6| 7| 3| DAY ON TEST | 2| 8| 4| 7| 1| 9| 8| 6| 6| 2| 3| 4| 6| 5| 8| 5| 8| 5| 1| 7| 3| 9| 4| 1| 5| | 9| 9| 1| 6| 9| 1| 3| 7| 8| 3| 2| 1| 2| 8| 5| 1| 3| 5| 3| 2| 5| 9| 8| 2| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.13% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Inflammation, Chronic Active | 1 1 1 2 1 2 2 2 4 3 2 2 2 2 2 3 2 1 1 2 1 2 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | Inflammation, Chronic Active | 4 2 2 2 2 2 2 2 3 1 1 2 1 2 1 3 2 2 2| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | 4 | Germinal Epithelium, Degeneration | 2 | Interstitial Cell, Hyperplasia | 2 1 1 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 4 3 3 3 4 4 3 4 4 4 4 4 4 | __________________________________________________________________________| Lymph Node | + + + + + +| Lumbar, Hyperplasia, Lymphoid | | Mediastinal, Hyperplasia, Plasma Cell| | Renal, Ectasia | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Spleen | X | Congestion | | Fibrosis | 2 2 4 2 2 | Hematopoietic Cell Proliferation | 2 2 3 | Necrosis | 4 | __________________________________________________________________________| Thymus | + + + + + M M M + + + + + + + + + + M + + + + + +| Cyst | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 4 | Hyperplasia, Cystic | 2 1 1 2 2 2 3 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 4 3 4 2 3 2 4 4 4 4 3 3 2 | Necrosis | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 53 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 _____________________________________________________________________________________________________________________ | 5| 5| 6| 5| 6| 6| 6| 6| 6| 7| 6| 6| 5| 5| 5| 5| 6| 6| 6| 5| 6| 5| 6| 7| 3| DAY ON TEST | 2| 8| 4| 7| 1| 9| 8| 6| 6| 2| 3| 4| 6| 5| 8| 5| 8| 5| 1| 7| 3| 9| 4| 1| 5| | 9| 9| 1| 6| 9| 1| 3| 7| 8| 3| 2| 1| 2| 8| 5| 1| 3| 5| 3| 2| 5| 9| 8| 2| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.13% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | Hemorrhage | 3 2 3| Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 1 | Alveolar Epithelium, Hyperplasia | 2 | Alveolus, Hemorrhage | 2 | Alveolus, Infiltration Cellular, | | Histiocyte | 1 1 1 1 1 1 1 1 1 | Alveolus, Inflammation, Suppurative | | Artery, Vein, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Interstitium, Mineralization | 2 | Perivascular, Infiltration Cellular, | | Lymphocyte | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 2 | Inflammation, Suppurative | 2 | Nasolacrimal Duct, Inflammation, | | Suppurative | 3 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Anterior Chamber, Inflammation, | | Suppurative | | Lens, Cataract | 3 | Retina, Degeneration | 4 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 2 2 | Nephropathy, Chronic | 3 2 4 4 4 4 4 3 4 3 4 4 2 3 2 4 4 4 2 3 4 4 4 4 2| Renal Tubule, Hyperplasia | 1 3 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 54 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 6| 6| 7| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 5| 4| 6| | DAY ON TEST | 1| 1| 8| 5| 2| 2| 8| 8| 2| 6| 7| 3| 7| 3| 6| 9| 4| 8| 6| 5| 2| 2| 6| 3| 9| | | 3| 2| 8| 4| 7| 3| 9| 3| 7| 4| 4| 1| 3| 5| 9| 7| 3| 3| 7| 9| 3| 3| 1| 7| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 0.13% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 3 | 1 3.0| Ulcer | 4 | 1 4.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 | Parasite Metazoan | | 1 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 | Ulcer | | 1 4.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X X | 8 | Clear Cell Focus | X X | 2 | Eosinophilic Focus | X X X | 5 | Hepatodiaphragmatic Nodule | X X X X | 5 | Inflammation, Chronic | 1 1 1 1 1 2 1 1 1 1 2 1| 22 1.3| Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 1 | 15 1.1| Bile Duct, Hyperplasia | 1 1 2 1 3 3 2 1 2 1 1 1 1 3 2 1 2 2 2 1 2 3 3 1 1| 50 1.9| Hepatocyte, Degeneration, Cystic | 1 1 1 3 2 1 2 1 2 2 2 2 2 1 | 27 1.7| Hepatocyte, Necrosis | 1 3 3 3 | 6 2.3| Hepatocyte, Vacuolization Cytoplasmic| 3 2 2 3 2 3 4 1 3 1 1 1 2 1 3 1 3 1 2 3| 33 2.0| Hepatocyte, Centrilobular, | | | Hypertrophy | 2 2 3 3 2 2 2 3 2 2 1 2 2 1 2 2| 33 2.0| __________________________________________________________________________|____________| Mesentery | + + + + +| 9 | Hemorrhage | | 1 4.0| Inflammation, Chronic Active | | 1 3.0| Fat, Inflammation, Chronic Active | | 1 3.0| Fat, Mineralization | 3| 1 3.0| Fat, Necrosis | 4 4 4 4| 4 4.0| Fat, Pigmentation, Hematoidin | 1| 1 1.0| Fat, Pigmentation, Hemosiderin | 3| 1 3.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acinus, Atrophy | 1 1 2 1 1 1 1 1 | 12 1.1| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 4.0| Mineralization | 3 3 | 3 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 55 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 6| 6| 7| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 5| 4| 6| | DAY ON TEST | 1| 1| 8| 5| 2| 2| 8| 8| 2| 6| 7| 3| 7| 3| 6| 9| 4| 8| 6| 5| 2| 2| 6| 3| 9| | | 3| 2| 8| 4| 7| 3| 9| 3| 7| 4| 4| 1| 3| 5| 9| 7| 3| 3| 7| 9| 3| 3| 1| 7| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 0.13% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Perforation | | 1 | Epithelium, Hyperplasia | 2 3 2 3 2 2 2 3 2 | 19 2.3| Epithelium, Inflammation, Chronic | | | Active | 2 3 4 3 | 14 3.0| Epithelium, Ulcer | 4 4 4 | 13 3.8| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 3 3 1 1 2 3 3 2 1| 15 2.1| Epithelium, Inflammation, Chronic | | | Active | 2 | 1 2.0| Epithelium, Necrosis | 3 | 2 2.5| __________________________________________________________________________|____________| Tongue | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Aorta, Mineralization | 3 4 2 4 3 4 3| 9 3.0| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy, Chronic | 3 3 2 2 2 2 2 3 2 3 2 2 3 2 3 3 2 2 2 2 1 3| 43 2.1| Mineralization | 1 2 2 1 2 3 3 | 8 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | 2 | 1 2.0| Atrophy | | 1 3.0| Degeneration, Fatty | 3 1 1 2 1 2 1 2 2 1 | 19 1.8| Hyperplasia | 2 2 1 4 2 | 9 1.8| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 1 2 2 1 1 1 4 2 4 1 3 2 4 1| 30 1.9| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + M + + + + + M + + + + + + + M + + + + + M + +| 46 | Hyperplasia | 3 3 4 2 3 2 4 4 4 3 2| 26 2.9| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + M + + + + + + + + + M + + + + + + + +| 48 | Pars Distalis, Cyst | 2 | 2 2.5| Pars Distalis, Hyperplasia | 2 2 2 1 2 2 1 | 16 1.6| Pars Intermedia, Cyst | | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 | C-Cell, Hyperplasia | 1 2 3 1 | 5 1.6| Follicle, Cyst | 3 | 1 3.0| Follicle, Hyperplasia, Cystic | | 1 2.0| Follicular Cell, Hyperplasia, Cystic | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 56 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 6| 6| 7| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 5| 4| 6| | DAY ON TEST | 1| 1| 8| 5| 2| 2| 8| 8| 2| 6| 7| 3| 7| 3| 6| 9| 4| 8| 6| 5| 2| 2| 6| 3| 9| | | 3| 2| 8| 4| 7| 3| 9| 3| 7| 4| 4| 1| 3| 5| 9| 7| 3| 3| 7| 9| 3| 3| 1| 7| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 0.13% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Peritoneum | + | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granuloma Sperm | 3 3 1| 3 2.3| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 3 | 3 3.3| Hyperplasia | 2 2 | 3 1.7| Inflammation, Chronic Active | 2 2 2 2 1 2 2 2 2 1 1 2 2 2 2 2 2 2| 40 1.9| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 2.0| Inflammation, Chronic Active | 2 2 2 3 2 2 1 3 3 1 2 1 1 2 1| 34 1.9| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 2 | 2 2.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Necrosis | | 1 4.0| Germinal Epithelium, Degeneration | 3 | 2 2.5| Interstitial Cell, Hyperplasia | 1 1 2 2 | 8 1.4| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 4 4 4 4 4 3 4 4 3 3 4 3 4 4| 28 3.7| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + +| 16 | Lumbar, Hyperplasia, Lymphoid | 3 | 1 3.0| Mediastinal, Hyperplasia, Plasma Cell| 2| 1 2.0| Renal, Ectasia | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + M + + + + + + + + + M + + + + + + + +| 48 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 3 2 3 | 4 2.8| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Spleen | | 1 | Congestion | 3| 1 3.0| Fibrosis | 2 2 2 3| 9 2.3| Hematopoietic Cell Proliferation | 2 2 2 | 6 2.2| Necrosis | | 1 4.0| __________________________________________________________________________|____________| Thymus | + + + M + + + + + + + M + + + + + + + + + + + + +| 44 | Cyst | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 57 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 6| 6| 7| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 5| 4| 6| | DAY ON TEST | 1| 1| 8| 5| 2| 2| 8| 8| 2| 6| 7| 3| 7| 3| 6| 9| 4| 8| 6| 5| 2| 2| 6| 3| 9| | | 3| 2| 8| 4| 7| 3| 9| 3| 7| 4| 4| 1| 3| 5| 9| 7| 3| 3| 7| 9| 3| 3| 1| 7| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 0.13% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 3 | 2 3.5| Hyperplasia, Cystic | 1 3 2 3 2 1 2 2 2 | 16 1.9| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | 4 4 3 2 2 3 2 4 3 4 4 2 4| 26 3.2| Necrosis | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 | Hemorrhage | 3 | 4 2.8| Inflammation, Chronic Active | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 | 3 1.7| Alveolar Epithelium, Hyperplasia | 2 | 2 2.0| Alveolus, Hemorrhage | | 1 2.0| Alveolus, Infiltration Cellular, | | | Histiocyte | 1 1 1 1 1 1 1 1 1 1| 19 1.0| Alveolus, Inflammation, Suppurative | 2 | 1 2.0| Artery, Vein, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 43 1.0| Interstitium, Mineralization | 2 2 2 2 2 3 | 7 2.1| Perivascular, Infiltration Cellular, | | | Lymphocyte | 1 | 1 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 3 2 2 2 2 3 4 | 10 2.4| Inflammation, Suppurative | 4 2 | 3 2.7| Nasolacrimal Duct, Inflammation, | | | Suppurative | | 2 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 58 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 6| 6| 7| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 5| 4| 6| | DAY ON TEST | 1| 1| 8| 5| 2| 2| 8| 8| 2| 6| 7| 3| 7| 3| 6| 9| 4| 8| 6| 5| 2| 2| 6| 3| 9| | | 3| 2| 8| 4| 7| 3| 9| 3| 7| 4| 4| 1| 3| 5| 9| 7| 3| 3| 7| 9| 3| 3| 1| 7| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 0.13% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | Anterior Chamber, Inflammation, | | | Suppurative | 2 | 1 2.0| Lens, Cataract | | 1 3.0| Retina, Degeneration | 3 | 2 3.5| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 2 2 2 3 2 2 3 2 3| 12 2.3| Nephropathy, Chronic | 4 4 4 4 3 3 2 3 3 4 3 4 4 2 4 4 4 4 4 3 3 3 3 2 4| 50 3.4| Renal Tubule, Hyperplasia | 1 4| 4 2.3| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 59 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 _____________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 6| 6| 6| 5| 5| 5| 4| 5| 4| 5| 5| 5| 2| 5| 5| 5| 5| 5| 5| 5| DAY ON TEST | 3| 7| 8| 6| 7| 1| 7| 3| 8| 8| 8| 3| 3| 3| 8| 3| 8| 5| 8| 6| 8| 8| 9| 8| 9| | 8| 2| 9| 1| 3| 0| 4| 2| 5| 8| 9| 6| 3| 7| 9| 2| 9| 4| 9| 2| 5| 5| 9| 3| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.25% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + M + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | M + + + + + + + + + + + + + + + + A + + + + + + +| Mineralization | | Muscularis, Mineralization | | __________________________________________________________________________| Intestine Large, Rectum | A + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Cecum | A + + + + + + + + + + + + + + + + A + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + A + + + A + + +| __________________________________________________________________________| Intestine Small, Ileum | M + + + + + + + + + + + + + + + + A + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X | Clear Cell Focus | X | Eosinophilic Focus | X X | Hepatodiaphragmatic Nodule | X | Inflammation, Chronic | 1 1 1 1 1 2 1 2 1 1 1 2 1| Mixed Cell Focus | X | Pigmentation, Hemosiderin | 1 2 1 1 1 2 1 1| Bile Duct, Hyperplasia | 1 2 2 1 1 3 2 1 2 2 3 1 1 2 1 1 1 1 1 2 2| Hepatocyte, Degeneration, Cystic | 1 2 4 2 1 1 1 1 | Hepatocyte, Necrosis | 2 2 3 1 2 2 | Hepatocyte, Vacuolization Cytoplasmic| 3 3 3 2 3 2 2 3 2 3 2 1 3 3 2 1 2 3 3 3 2 2 2| Hepatocyte, Centrilobular, | | Hypertrophy | 2 2 2 1 2 2 2 2 2 3 2 3 2 3 3 3 3 2 3 1 2| __________________________________________________________________________| Mesentery | + | Angiectasis | | Inflammation, Chronic Active | | Artery, Inflammation, Chronic Active | | Artery, Mineralization | | Artery, Necrosis, Fibrinoid | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 2 1 1 | Acinus, Hypertrophy | 2 | __________________________________________________________________________| Salivary Glands | + M + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 4| Mineralization | 1 1 2 2 2 | Epithelium, Hyperplasia | 2 2 3| Epithelium, Inflammation, Chronic | | Active | 2 2 | Epithelium, Ulcer | 4 4| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 3 3 2 2 2 2 2 3 2 3 3 2 3 3 2 3 2 3 2| Epithelium, Necrosis | | _____________________________________________________________________________________________________________________| Page 60 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 _____________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 6| 6| 6| 5| 5| 5| 4| 5| 4| 5| 5| 5| 2| 5| 5| 5| 5| 5| 5| 5| DAY ON TEST | 3| 7| 8| 6| 7| 1| 7| 3| 8| 8| 8| 3| 3| 3| 8| 3| 8| 5| 8| 6| 8| 8| 9| 8| 9| | 8| 2| 9| 1| 3| 0| 4| 2| 5| 8| 9| 6| 3| 7| 9| 2| 9| 4| 9| 2| 5| 5| 9| 3| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.25% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 4 | Necrosis, Fibrinoid | 2 | Aorta, Mineralization | 3 2 3 2 3 3 4 3 4 3 3 3 4 3 1 4 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy, Chronic | 3 3 3 2 3 2 2 3 3 2 1 2 3 2 3 3 2 2 1 2 3 3 3 2| Mineralization | 1 2 2 2 2 2 3 2 | Atrium, Thrombosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Fatty | 2 1 2 1 1 | Hyperplasia | 2 2 1 2| Mineralization | 3 | Necrosis | 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + M + + + + + + +| Hyperplasia | 1 3 2 2 1 2 2 1 1 1 1 1 1 2 2 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 3 2 3 3 2 4 3 2 3 2 3 3 4 2 2 4 3 3 3| __________________________________________________________________________| Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| Craniopharyngeal Duct, Cyst | 2 | Pars Distalis, Cyst | 3 2 | Pars Distalis, Hyperplasia | 2 2 2 | Pars Intermedia, Cyst | | __________________________________________________________________________| Thyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | | Follicle, Cyst | 4 3 3 2 | Follicular Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Coagulating Gland | | Inflammation, Chronic Active | | __________________________________________________________________________| Epididymis | M + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | 2 | Mineralization | 3 4 2 | Necrosis | 4 | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 3 | _____________________________________________________________________________________________________________________| Page 61 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 _____________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 6| 6| 6| 5| 5| 5| 4| 5| 4| 5| 5| 5| 2| 5| 5| 5| 5| 5| 5| 5| DAY ON TEST | 3| 7| 8| 6| 7| 1| 7| 3| 8| 8| 8| 3| 3| 3| 8| 3| 8| 5| 8| 6| 8| 8| 9| 8| 9| | 8| 2| 9| 1| 3| 0| 4| 2| 5| 8| 9| 6| 3| 7| 9| 2| 9| 4| 9| 2| 5| 5| 9| 3| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.25% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Inflammation, Chronic Active | 1 2 1 2 2 2 2 2 2 1 2 2 2 2 1 2 2 3 1 1 1 2 2 2 1| __________________________________________________________________________| Prostate | M + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 1 3 2 3 1 2 1 1 1 2 2 4 2 2 | Mineralization | 2 1 | __________________________________________________________________________| Seminal Vesicle | M + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Mineralization | 3 2 3 | __________________________________________________________________________| Testes | M + + + + + + + + + + + + + + + + + + + + + + + +| Germinal Epithelium, Degeneration | 1 | Interstitial Cell, Hyperplasia | 1 1 2 1 1 1 2| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 | Hyperplasia | 4 3 4 4 3 4 | Myelofibrosis | 1 | __________________________________________________________________________| Lymph Node | + + + + + + | Renal, Ectasia | 2 2 | Renal, Erythrophagocytosis | 3 | Renal, Pigmentation, Hemosiderin | 1 | __________________________________________________________________________| Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 3 | Fibrosis | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 2 2 3 3 1 | Hematopoietic Cell Proliferation | | Necrosis | | __________________________________________________________________________| Thymus | + M + + + + + + M + M + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Cystic | 2 1 2 1 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Basal Cell | | Inflammation, Suppurative | 3 | Pinna, Ulcer | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 3 3 4 2 3 4 3 2 3 2 2 3 3 4 3 3 3 4 2| Osteopetrosis | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 62 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 _____________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 6| 6| 6| 5| 5| 5| 4| 5| 4| 5| 5| 5| 2| 5| 5| 5| 5| 5| 5| 5| DAY ON TEST | 3| 7| 8| 6| 7| 1| 7| 3| 8| 8| 8| 3| 3| 3| 8| 3| 8| 5| 8| 6| 8| 8| 9| 8| 9| | 8| 2| 9| 1| 3| 0| 4| 2| 5| 8| 9| 6| 3| 7| 9| 2| 9| 4| 9| 2| 5| 5| 9| 3| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.25% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | __________________________________________________________________________| Brain | + M + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | Metaplasia, Osseous | 2 | Alveolar Epithelium, Hyperplasia | 2 2| Alveolus, Infiltration Cellular, | | Histiocyte | 1 1 1 1 1 1 | Alveolus, Inflammation, Suppurative | 2 2 3 | Artery, Vein, Mineralization | 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1| Interstitium, Inflammation, Chronic | | Active | 2 1 | Interstitium, Mineralization | 3 3 1 3 2 3 1 2 3 2 3 2 2 3 | Interstitium, Alveolus, Inflammation,| | Suppurative | 2 2 2 2 | Perivascular, Infiltration Cellular, | | Lymphocyte | 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 2 3 2 | Inflammation, Suppurative | 1 2 2 2 2 | Arteriole, Venule, Thrombosis | | Nasolacrimal Duct, Inflammation, | | Suppurative | 2 | Respiratory Epithelium, Metaplasia, | | Squamous | 3 | __________________________________________________________________________| Trachea | + M + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 3 3 3| Nephropathy, Chronic | 4 4 4 4 4 4 3 4 4 4 3 3 4 4 4 4 4 4 3 4 4 4 4 3 4| Renal Tubule, Hyperplasia | 2 1 4 | __________________________________________________________________________| Urinary Bladder | M + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 4 | _____________________________________________________________________________________________________________________| Page 63 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 __________________________________________________________________________________________________________________________________ | 5| 5| 6| 6| 5| 4| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 6| 6| 3| 5| 5| 5| 5| 5| 5| | DAY ON TEST | 4| 9| 4| 0| 8| 3| 6| 8| 6| 1| 4| 3| 1| 8| 2| 6| 2| 1| 8| 2| 5| 4| 8| 5| 0| | | 8| 6| 1| 3| 9| 7| 0| 1| 1| 9| 2| 7| 7| 3| 9| 9| 6| 9| 0| 2| 6| 4| 9| 9| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 0.25% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Colon | M + + + + + + + + + + + + + + + + + A + + + + + +| 46 | Mineralization | 2 2 | 2 2.0| Muscularis, Mineralization | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Large, Rectum | M + + + + + + + + + + + + + + + + + A + + + + + +| 47 | Parasite Metazoan | | 2 | __________________________________________________________________________|____________| Intestine Large, Cecum | M + + + + + + + + + + + + + + + + + A + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Small, Duodenum | M + + + + + + + + + + + + + + + + + A + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Jejunum | M + + + + + + + + + + + + + + + + + A + + + + + +| 45 | __________________________________________________________________________|____________| Intestine Small, Ileum | M + + + + + + + + + + + + + + + + + A + + + + + +| 46 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X | 6 | Clear Cell Focus | | 1 | Eosinophilic Focus | | 2 | Hepatodiaphragmatic Nodule | X X | 3 | Inflammation, Chronic | 2 1 1 1 1 2 1 1 1 2 1| 24 1.3| Mixed Cell Focus | | 1 | Pigmentation, Hemosiderin | 1 1 2 1 1 1 2 1 1 1 1| 19 1.2| Bile Duct, Hyperplasia | 1 1 2 2 1 2 3 1 1 2 2 1 1 1 1 1 1 1 1 1 2 2 1| 44 1.5| Hepatocyte, Degeneration, Cystic | 2 2 1 1 2 1 1 1 1 2 | 18 1.5| Hepatocyte, Necrosis | 2 3 2 3 | 10 2.2| Hepatocyte, Vacuolization Cytoplasmic| 3 3 2 2 2 3 2 2 2 2 3 2 3 2 3 2 2 1 3 1| 43 2.3| Hepatocyte, Centrilobular, | | | Hypertrophy | 2 3 1 2 2 3 3 3 3 3 3 2 3 3 2 3 3 3 3 | 40 2.4| __________________________________________________________________________|____________| Mesentery | + + | 3 | Angiectasis | 3 | 1 3.0| Inflammation, Chronic Active | 3 | 1 3.0| Artery, Inflammation, Chronic Active | 3 | 1 3.0| Artery, Mineralization | 3 | 1 3.0| Artery, Necrosis, Fibrinoid | 3 | 1 3.0| __________________________________________________________________________|____________| Pancreas | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Acinus, Atrophy | 1 1 1 1 1| 8 1.1| Acinus, Hypertrophy | | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | | 1 4.0| Mineralization | 2 2 3 2 2 2 1 | 12 1.8| Epithelium, Hyperplasia | 3 3 2 2 2 2 2 | 10 2.3| Epithelium, Inflammation, Chronic | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 64 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 __________________________________________________________________________________________________________________________________ | 5| 5| 6| 6| 5| 4| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 6| 6| 3| 5| 5| 5| 5| 5| 5| | DAY ON TEST | 4| 9| 4| 0| 8| 3| 6| 8| 6| 1| 4| 3| 1| 8| 2| 6| 2| 1| 8| 2| 5| 4| 8| 5| 0| | | 8| 6| 1| 3| 9| 7| 0| 1| 1| 9| 2| 7| 7| 3| 9| 9| 6| 9| 0| 2| 6| 4| 9| 9| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 0.25% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Active | 3 3 3 2 2 2 2 | 9 2.3| Epithelium, Ulcer | 4 4 4 3 4 4 | 8 3.9| __________________________________________________________________________|____________| Stomach, Glandular | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Mineralization | 3 2 3 3 3 3 3 2 3 3 3 1 2 3 3 3 2| 36 2.6| Epithelium, Necrosis | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 4.0| Necrosis, Fibrinoid | | 1 2.0| Aorta, Mineralization | 3 4 4 3 3 4 3 3 3 1 2 3 4 4 2| 31 3.0| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy, Chronic | 3 3 2 1 2 2 2 3 1 2 3 2 3 2 3 3 2 2 2 1 1 3 2 2| 48 2.3| Mineralization | 2 2 3 3 2 2 2 | 15 2.1| Atrium, Thrombosis | 4 2 | 2 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Fatty | 3 2 2 1 2 1 1| 12 1.6| Hyperplasia | 2 2 | 6 1.8| Mineralization | | 1 3.0| Necrosis | | 1 2.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 1 2 1 2 2 2 2 1 2 2 2 2 2| 29 1.7| __________________________________________________________________________|____________| Islets, Pancreatic | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 2 3 2 3 3 3 3 2 3 3 3 2 3 3 3 2 2 3 3 2| 40 2.8| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Craniopharyngeal Duct, Cyst | | 1 2.0| Pars Distalis, Cyst | 1 1 | 4 1.8| Pars Distalis, Hyperplasia | 2 2 2 2 | 7 2.0| Pars Intermedia, Cyst | 1 | 1 1.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | C-Cell, Hyperplasia | 1 2 1 | 3 1.3| Follicle, Cyst | 3 2 | 6 2.8| Follicular Cell, Hyperplasia | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Peritoneum | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 65 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 __________________________________________________________________________________________________________________________________ | 5| 5| 6| 6| 5| 4| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 6| 6| 3| 5| 5| 5| 5| 5| 5| | DAY ON TEST | 4| 9| 4| 0| 8| 3| 6| 8| 6| 1| 4| 3| 1| 8| 2| 6| 2| 1| 8| 2| 5| 4| 8| 5| 0| | | 8| 6| 1| 3| 9| 7| 0| 1| 1| 9| 2| 7| 7| 3| 9| 9| 6| 9| 0| 2| 6| 4| 9| 9| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 0.25% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Coagulating Gland | + | 1 | Inflammation, Chronic Active | 3 | 1 3.0| __________________________________________________________________________|____________| Epididymis | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Granuloma Sperm | | 1 2.0| Mineralization | 3 | 4 3.0| Necrosis | | 1 4.0| __________________________________________________________________________|____________| Preputial Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 2 2 | 4 2.8| Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 1 1 1 2 2 1 1 1 2 2 1 2| 45 1.7| __________________________________________________________________________|____________| Prostate | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Inflammation, Chronic Active | 2 2 2 2 2 3 2 1 1 1 2 2 1 1 2 | 30 1.8| Mineralization | | 2 1.5| __________________________________________________________________________|____________| Seminal Vesicle | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Atrophy | 3 3 | 2 3.0| Mineralization | 2 3 3 3 2 | 8 2.6| __________________________________________________________________________|____________| Testes | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Germinal Epithelium, Degeneration | 2 4 | 3 2.3| Interstitial Cell, Hyperplasia | 1 1 1 2 | 11 1.3| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 4.0| Hyperplasia | 4 4 4 4 3 4 | 12 3.8| Myelofibrosis | | 1 1.0| __________________________________________________________________________|____________| Lymph Node | + + + + | 10 | Renal, Ectasia | 3 | 3 2.3| Renal, Erythrophagocytosis | | 1 3.0| Renal, Pigmentation, Hemosiderin | 2 | 2 1.5| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Ectasia | 2 | 2 2.5| Fibrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Spleen | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Fibrosis | 3 3 3 2 4 1 | 12 2.4| Hematopoietic Cell Proliferation | 2 | 1 2.0| Necrosis | 4 | 1 4.0| __________________________________________________________________________|____________| Thymus | + + M + + + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 66 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 __________________________________________________________________________________________________________________________________ | 5| 5| 6| 6| 5| 4| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 6| 6| 3| 5| 5| 5| 5| 5| 5| | DAY ON TEST | 4| 9| 4| 0| 8| 3| 6| 8| 6| 1| 4| 3| 1| 8| 2| 6| 2| 1| 8| 2| 5| 4| 8| 5| 0| | | 8| 6| 1| 3| 9| 7| 0| 1| 1| 9| 2| 7| 7| 3| 9| 9| 6| 9| 0| 2| 6| 4| 9| 9| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 0.25% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M + + + + M + + + + + + + + M + + + + + + + + + +| 47 | Hyperplasia, Cystic | 1 1 | 6 1.3| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Basal Cell | 2 | 1 2.0| Inflammation, Suppurative | | 1 3.0| Pinna, Ulcer | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | 3 3 2 4 4 2 3 4 3 3 4 4 4 4 3 4 4 3| 37 3.2| Osteopetrosis | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemorrhage | | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 1 1| 3 1.3| Metaplasia, Osseous | 1 | 2 1.5| Alveolar Epithelium, Hyperplasia | 3 3 | 4 2.5| Alveolus, Infiltration Cellular, | | | Histiocyte | 1 1 1 1 1 1 1 1 1 | 15 1.0| Alveolus, Inflammation, Suppurative | 2 | 4 2.3| Artery, Vein, Mineralization | 1 2 1 1 1 1 2 1 1 2 2 1 2 1 1 1 1 1 2 1 1| 45 1.2| Interstitium, Inflammation, Chronic | | | Active | | 2 1.5| Interstitium, Mineralization | 3 2 3 2 2 3 3 3 3 3 2 | 25 2.5| Interstitium, Alveolus, Inflammation,| | | Suppurative | 2 | 5 2.0| Perivascular, Infiltration Cellular, | | | Lymphocyte | | 1 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 3 3 2 3 1 | 9 2.3| Inflammation, Suppurative | 3 3 2 2| 9 2.1| Arteriole, Venule, Thrombosis | 4 | 1 4.0| Nasolacrimal Duct, Inflammation, | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 67 NTP Experiment-Test: 88035-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PRIMACLONE Date: 10/01/96 Route: DOSED FEED Time: 10:48:28 __________________________________________________________________________________________________________________________________ | 5| 5| 6| 6| 5| 4| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 6| 6| 3| 5| 5| 5| 5| 5| 5| | DAY ON TEST | 4| 9| 4| 0| 8| 3| 6| 8| 6| 1| 4| 3| 1| 8| 2| 6| 2| 1| 8| 2| 5| 4| 8| 5| 0| | | 8| 6| 1| 3| 9| 7| 0| 1| 1| 9| 2| 7| 7| 3| 9| 9| 6| 9| 0| 2| 6| 4| 9| 9| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 0.25% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Suppurative | 2 | 2 2.0| Respiratory Epithelium, Metaplasia, | | | Squamous | | 1 3.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 2 2 2 4 3 | 9 2.8| Nephropathy, Chronic | 4 4 4 4 4 2 3 4 4 3 4 4 4 4 4 4 4 4 2 4 4 3 4 4 4| 50 3.8| Renal Tubule, Hyperplasia | 3 4 2 2 2 1 4| 10 2.5| __________________________________________________________________________|____________| Urinary Bladder | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hemorrhage | | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 68 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------