TDMS Study 88036-03 Pathology Tables
NTP Experiment-Test: 88036-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:22:18
14 WEEK SSAC RATS
Facility: Battelle Columbus Laboratory
Chemical CAS #: 84-65-1
Lock Date: 07/23/97
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 02/13/95 - 02/14/95
Treatment Groups: Include 002 0 PPM
Include 010 3750 PPM
Include 001 0 PPM
Include 009 3750 PPM
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 88036-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:22:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 3750 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60
Scheduled Sacrifice 5 5
Early Deaths
Survivors
Animals Examined Microscopically 5 5
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (5) (5)
Inflammation 1 (20%)
Centrilobular, Hypertrophy 5 (100%)
Pancreas (5) (5)
Inflammation 1 (20%)
Stomach, Glandular (5) (5)
Erosion 1 (20%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (5) (5)
Cardiomyopathy 1 (20%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Thyroid Gland (5) (5)
Follicular Cell, Hypertrophy 4 (80%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (5) (5)
Cyst 1 (20%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88036-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:22:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 3750 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Spleen (5) (5)
Congestion 5 (100%)
Pigmentation 4 (80%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (5) (5)
Alveolar Epithelium, Hyperplasia 1 (20%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (5) (5)
Accumulation, Hyaline Droplet 5 (100%)
Nephropathy 1 (20%) 2 (40%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88036-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:22:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 3750 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60
Scheduled Sacrifice 5 5
Early Deaths
Survivors
Animals Examined Microscopically 5 5
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (5) (5)
Centrilobular, Hypertrophy 5 (100%)
Pancreas (5) (5)
Atrophy 1 (20%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (5) (5)
Cardiomyopathy 3 (60%) 3 (60%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Thyroid Gland (5) (5)
Follicular Cell, Hypertrophy 5 (100%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Spleen (5) (5)
Accessory Spleen 1 (20%)
Congestion 5 (100%)
Capsule, Hyperplasia 1 (20%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88036-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:22:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 3750 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (5) (5)
Inflammation 3 (60%)
Nose (5) (5)
Inflammation 1 (20%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (5) (5)
Accumulation, Hyaline Droplet 5 (100%)
Nephropathy 5 (100%) 5 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
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