https://ntp.niehs.nih.gov/go/4740

TDMS Study 88036-03 Pathology Tables

NTP Experiment-Test: 88036-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99
Route: DOSED FEED                                                                                                 Time: 11:22:18
                                                       14 WEEK SSAC RATS
       Facility:  Battelle Columbus Laboratory
       Chemical CAS #:  84-65-1
       Lock Date:  07/23/97
       Cage Range:  All
       Reasons For Removal:    25017 Scheduled Sacrifice
       Removal Date Range:     02/13/95 - 02/14/95
       Treatment Groups:       Include 002    0 PPM
                               Include 010    3750 PPM
                               Include 001    0 PPM
                               Include 009    3750 PPM
a  Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 88036-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:22:18  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        3750 PPM                                                            
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60                                                               
  Scheduled Sacrifice                                  5            5                                                               
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
  Animals Examined Microscopically                     5            5                                                               
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Liver                                              (5)          (5)                                                              
      Inflammation                                     1 (20%)                                                                      
      Centrilobular, Hypertrophy                                    5 (100%)                                                        
   Pancreas                                           (5)          (5)                                                              
      Inflammation                                                  1 (20%)                                                         
   Stomach, Glandular                                 (5)          (5)                                                              
      Erosion                                                       1 (20%)                                                         
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (5)          (5)                                                              
      Cardiomyopathy                                                1 (20%)                                                         
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Thyroid Gland                                      (5)          (5)                                                              
      Follicular Cell, Hypertrophy                                  4 (80%)                                                         
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Ovary                                              (5)          (5)                                                              
      Cyst                                             1 (20%)                                                                      
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88036-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:22:18  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        3750 PPM                                                            
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Spleen                                             (5)          (5)                                                              
      Congestion                                                    5 (100%)                                                        
      Pigmentation                                                  4 (80%)                                                         
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (5)          (5)                                                              
      Alveolar Epithelium, Hyperplasia                              1 (20%)                                                         
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (5)          (5)                                                              
      Accumulation, Hyaline Droplet                                 5 (100%)                                                        
      Nephropathy                                      1 (20%)      2 (40%)                                                         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88036-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:22:18  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        3750 PPM                                                            
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60                                                               
  Scheduled Sacrifice                                  5            5                                                               
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
  Animals Examined Microscopically                     5            5                                                               
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Liver                                              (5)          (5)                                                              
      Centrilobular, Hypertrophy                                    5 (100%)                                                        
   Pancreas                                           (5)          (5)                                                              
      Atrophy                                                       1 (20%)                                                         
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (5)          (5)                                                              
      Cardiomyopathy                                   3 (60%)      3 (60%)                                                         
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Thyroid Gland                                      (5)          (5)                                                              
      Follicular Cell, Hypertrophy                                  5 (100%)                                                        
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Spleen                                             (5)          (5)                                                              
      Accessory Spleen                                 1 (20%)                                                                      
      Congestion                                                    5 (100%)                                                        
      Capsule, Hyperplasia                                          1 (20%)                                                         
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88036-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:22:18  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        3750 PPM                                                            
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (5)          (5)                                                              
      Inflammation                                                  3 (60%)                                                         
   Nose                                               (5)          (5)                                                              
      Inflammation                                                  1 (20%)                                                         
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (5)          (5)                                                              
      Accumulation, Hyaline Droplet                                 5 (100%)                                                        
      Nephropathy                                      5 (100%)     5 (100%)                                                        
a  Number of animals examined microscopically at site and number of animals with lesion                                             
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