TDMS Study 88036-03 Pathology Tables
NTP Experiment-Test: 88036-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:32:19
51 WEEK SSAC RATS
Facility: Battelle Columbus Laboratory
Chemical CAS #: 84-65-1
Lock Date: 07/23/97
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 11/01/95 - 11/01/95
Treatment Groups: Include 002 0 PPM
Include 010 3750 PPM
Include 001 0 PPM
Include 009 3750 PPM
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 88036-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:32:19
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 3750 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60
Scheduled Sacrifice 5 5
Early Deaths
Survivors
Animals Examined Microscopically 5 5
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Rectum (5) (5)
Parasite Metazoan 1 (20%)
Liver (5) (5)
Basophilic Focus 3 (60%)
Hepatodiaphragmatic Nodule 1 (20%)
Inflammation 3 (60%) 3 (60%)
Bile Duct, Hyperplasia 1 (20%)
Centrilobular, Hypertrophy 5 (100%)
Pancreas (5) (5)
Atrophy 2 (40%) 2 (40%)
Stomach, Glandular (5) (5)
Erosion 1 (20%)
Ulcer 1 (20%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (5) (5)
Cardiomyopathy 3 (60%) 1 (20%)
Inflammation 1 (20%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (5) (5)
Hyperplasia 1 (20%)
Pituitary Gland (5) (5)
Angiectasis 1 (20%) 1 (20%)
Cyst 1 (20%)
Pars Distalis, Hyperplasia 1 (20%) 1 (20%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88036-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:32:19
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 3750 PPM
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (5) (5)
Inflammation 5 (100%) 5 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (5) (5)
Hyperplasia 5 (100%)
Lymph Node, Mandibular (5) (5)
Hyperplasia, Plasma Cell 1 (20%)
Thymus (5) (5)
Atrophy 1 (20%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (5) (5)
Inflammation 5 (100%) 4 (80%)
Trachea (5) (5)
Inflammation 1 (20%) 3 (60%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88036-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:32:19
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 3750 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (5) (5)
Accumulation, Hyaline Droplet 2 (40%) 5 (100%)
Nephropathy 3 (60%) 5 (100%)
Medulla, Mineralization 1 (20%) 4 (80%)
Urinary Bladder (5) (5)
Inflammation 2 (40%) 1 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88036-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:32:19
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 3750 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60
Scheduled Sacrifice 5 5
Early Deaths
Survivors
Animals Examined Microscopically 5 5
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Rectum (5) (5)
Parasite Metazoan 2 (40%) 4 (80%)
Intestine Large, Cecum (5) (5)
Ulcer 1 (20%)
Liver (5) (5)
Basophilic Focus 2 (40%)
Hepatodiaphragmatic Nodule 1 (20%)
Inflammation 4 (80%) 3 (60%)
Necrosis 4 (80%) 1 (20%)
Vacuolization Cytoplasmic 4 (80%) 5 (100%)
Bile Duct, Hyperplasia 4 (80%) 4 (80%)
Centrilobular, Hypertrophy 5 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (5) (5)
Cardiomyopathy 5 (100%) 5 (100%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Pituitary Gland (5) (5)
Pars Distalis, Hyperplasia 1 (20%) 1 (20%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88036-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:32:19
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 3750 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (5) (5)
Inflammation 2 (40%)
Preputial Gland (5) (5)
Inflammation 5 (100%) 3 (60%)
Prostate (5) (5)
Inflammation 3 (60%) 4 (80%)
Testes (5) (5)
Atrophy 1 (20%)
Interstitial Cell, Hyperplasia 4 (80%) 4 (80%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (5) (5)
Hyperplasia 3 (60%)
Thymus (5) (5)
Atrophy 2 (40%) 4 (80%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (5) (5)
Inflammation 1 (20%) 2 (40%)
Nose (5) (5)
Inflammation 1 (20%) 1 (20%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88036-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:32:19
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 3750 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (5) (5)
Accumulation, Hyaline Droplet 5 (100%)
Nephropathy 5 (100%) 5 (100%)
Medulla, Mineralization 5 (100%)
Urinary Bladder (5) (5)
Inflammation 1 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
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