TDMS Study 88036-03 Pathology Tables
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:35:52
51 WEEK SSAC RATS
Facility: Battelle Columbus Laboratory
Chemical CAS #: 84-65-1
Lock Date: 07/23/97
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 11/01/95 - 11/01/95
Treatment Groups: Include 002 0 PPM
Include 010 3750 PPM
Include 001 0 PPM
Include 009 3750 PPM
Page 1
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:35:52
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| | |
DAY ON TEST | 5| 5| 5| 5| 5| | |
| 2| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 3| 3| | A |
0 PPM | 8| 8| 9| 1| 2| | L |
| 4| 8| 9| 7| 2| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 5 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 5 |
__________________________________________________________________________|____________|
Liver | + + + + + | 5 |
Basophilic Focus | X X X | 3 |
Inflammation | 1 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + | 5 |
Atrophy | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 5 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 5 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 5 |
Erosion | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + | 5 |
__________________________________________________________________________|____________|
Heart | + + + + + | 5 |
Cardiomyopathy | 1 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 5 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 5 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 5 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + | 4 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 5 |
Angiectasis | 1 | 1 1.0|
Pars Distalis, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:35:52
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| | |
DAY ON TEST | 5| 5| 5| 5| 5| | |
| 2| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 3| 3| | A |
0 PPM | 8| 8| 9| 1| 2| | L |
| 4| 8| 9| 7| 2| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation | 1 1 1 1 1 | 5 1.0|
__________________________________________________________________________|____________|
Ovary | + + + + + | 5 |
__________________________________________________________________________|____________|
Uterus | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 5 |
__________________________________________________________________________|____________|
Spleen | + + + + + | 5 |
__________________________________________________________________________|____________|
Thymus | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 5 |
__________________________________________________________________________|____________|
Skin | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 5 |
Inflammation | 1 1 1 1 1 | 5 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + | 5 |
__________________________________________________________________________|____________|
Trachea | + + + + + | 5 |
Inflammation | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 5 |
Accumulation, Hyaline Droplet | 1 1 | 2 1.0|
Nephropathy | 1 1 1 | 3 1.0|
Medulla, Mineralization | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 5 |
Inflammation | 1 1 | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:35:52
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| | |
DAY ON TEST | 5| 5| 5| 5| 5| | |
| 2| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 5| 5| 5| 5| | A |
3750 PPM | 8| 0| 1| 3| 3| | L |
| 2| 0| 3| 4| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 5 |
__________________________________________________________________________|____________|
Liver | + + + + + | 5 |
Hepatodiaphragmatic Nodule | X | 1 |
Inflammation | 1 1 1 | 3 1.0|
Bile Duct, Hyperplasia | 1 | 1 1.0|
Centrilobular, Hypertrophy | 2 2 2 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + | 5 |
Atrophy | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 5 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 5 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 5 |
Ulcer | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + | 5 |
__________________________________________________________________________|____________|
Heart | + + + + + | 5 |
Cardiomyopathy | 1 | 1 1.0|
Inflammation | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 5 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 5 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 5 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + | 5 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 5 |
Angiectasis | 2 | 1 2.0|
Cyst | 3 | 1 3.0|
Pars Distalis, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:35:52
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| | |
DAY ON TEST | 5| 5| 5| 5| 5| | |
| 2| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 5| 5| 5| 5| | A |
3750 PPM | 8| 0| 1| 3| 3| | L |
| 2| 0| 3| 4| 8| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + | 5 |
Inflammation | 1 1 1 1 1 | 5 1.0|
__________________________________________________________________________|____________|
Ovary | + + + + + | 5 |
__________________________________________________________________________|____________|
Uterus | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 5 |
Hyperplasia | 2 3 3 3 3 | 5 2.8|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 5 |
Hyperplasia, Plasma Cell | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 5 |
__________________________________________________________________________|____________|
Spleen | + + + + + | 5 |
__________________________________________________________________________|____________|
Thymus | + + + + + | 5 |
Atrophy | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 5 |
__________________________________________________________________________|____________|
Skin | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 5 |
Inflammation | 1 1 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + | 5 |
__________________________________________________________________________|____________|
Trachea | + + + + + | 5 |
Inflammation | 1 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 5 |
Accumulation, Hyaline Droplet | 4 3 4 3 3 | 5 3.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:35:52
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| | |
DAY ON TEST | 5| 5| 5| 5| 5| | |
| 2| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 5| 5| 5| 5| | A |
3750 PPM | 8| 0| 1| 3| 3| | L |
| 2| 0| 3| 4| 8| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Nephropathy | 1 1 1 1 1 | 5 1.0|
Medulla, Mineralization | 1 1 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 5 |
Inflammation | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:35:52
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| | |
DAY ON TEST | 5| 5| 5| 5| 5| | |
| 3| 3| 3| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
0 PPM | 3| 3| 3| 4| 5| | L |
| 3| 6| 7| 0| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 5 |
Parasite Metazoan | X X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 5 |
__________________________________________________________________________|____________|
Liver | + + + + + | 5 |
Basophilic Focus | X X | 2 |
Inflammation | 1 1 1 1 | 4 1.0|
Necrosis | 1 1 1 1 | 4 1.0|
Vacuolization Cytoplasmic | 1 2 1 1 | 4 1.3|
Bile Duct, Hyperplasia | 1 1 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + | 5 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 5 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 5 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + | 5 |
__________________________________________________________________________|____________|
Heart | + + + + + | 5 |
Cardiomyopathy | 1 1 1 1 1 | 5 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 5 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 5 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 5 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + | 5 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 5 |
Pars Distalis, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + | 5 |
Inflammation | 1 1 | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:35:52
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| | |
DAY ON TEST | 5| 5| 5| 5| 5| | |
| 3| 3| 3| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
0 PPM | 3| 3| 3| 4| 5| | L |
| 3| 6| 7| 0| 8| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 5 |
Inflammation | 1 1 1 1 1 | 5 1.0|
__________________________________________________________________________|____________|
Prostate | + + + + + | 5 |
Inflammation | 1 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + | 5 |
__________________________________________________________________________|____________|
Testes | + + + + + | 5 |
Atrophy | 1 | 1 1.0|
Interstitial Cell, Hyperplasia | 1 1 1 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 5 |
__________________________________________________________________________|____________|
Spleen | + + + + + | 5 |
__________________________________________________________________________|____________|
Thymus | + + + + + | 5 |
Atrophy | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 5 |
__________________________________________________________________________|____________|
Skin | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 5 |
Inflammation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + | 5 |
Inflammation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:35:52
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| | |
DAY ON TEST | 5| 5| 5| 5| 5| | |
| 3| 3| 3| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
0 PPM | 3| 3| 3| 4| 5| | L |
| 3| 6| 7| 0| 8| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Nephropathy | 1 1 1 1 1 | 5 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:35:52
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| | |
DAY ON TEST | 5| 5| 5| 5| 5| | |
| 3| 3| 3| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| | A |
3750 PPM | 2| 4| 4| 5| 6| | L |
| 8| 6| 7| 2| 9| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 5 |
Parasite Metazoan | X X X X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 5 |
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 5 |
__________________________________________________________________________|____________|
Liver | + + + + + | 5 |
Hepatodiaphragmatic Nodule | X | 1 |
Inflammation | 1 1 1 | 3 1.0|
Necrosis | 1 | 1 1.0|
Vacuolization Cytoplasmic | 1 1 1 1 2 | 5 1.2|
Bile Duct, Hyperplasia | 1 1 1 1 | 4 1.0|
Centrilobular, Hypertrophy | 2 2 2 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + | 5 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 5 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 5 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + | 5 |
__________________________________________________________________________|____________|
Heart | + + + + + | 5 |
Cardiomyopathy | 1 1 1 1 1 | 5 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 5 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 5 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 5 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + | 5 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 5 |
Pars Distalis, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:35:52
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| | |
DAY ON TEST | 5| 5| 5| 5| 5| | |
| 3| 3| 3| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| | A |
3750 PPM | 2| 4| 4| 5| 6| | L |
| 8| 6| 7| 2| 9| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + | 5 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 5 |
Inflammation | 1 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Prostate | + + + + + | 5 |
Inflammation | 1 1 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + | 5 |
__________________________________________________________________________|____________|
Testes | + + + + + | 5 |
Interstitial Cell, Hyperplasia | 1 1 1 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 5 |
Hyperplasia | 1 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 5 |
__________________________________________________________________________|____________|
Spleen | + + + + + | 5 |
__________________________________________________________________________|____________|
Thymus | + + + + + | 5 |
Atrophy | 2 4 3 3 | 4 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 5 |
__________________________________________________________________________|____________|
Skin | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 5 |
Inflammation | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + | 5 |
Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:35:52
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| | |
DAY ON TEST | 5| 5| 5| 5| 5| | |
| 3| 3| 3| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| | A |
3750 PPM | 2| 4| 4| 5| 6| | L |
| 8| 6| 7| 2| 9| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 5 |
Accumulation, Hyaline Droplet | 3 3 3 3 2 | 5 2.8|
Nephropathy | 1 2 2 2 2 | 5 1.8|
Medulla, Mineralization | 2 1 1 1 1 | 5 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 5 |
Inflammation | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
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---------- END OF REPORT ----------
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