TDMS Study 88036-03 Pathology Tables
NTP Experiment-Test: 88036-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:42:51
2 YEAR CHRONIC RATS
Facility: Battelle Columbus Laboratory
Chemical CAS #: 84-65-1
Lock Date: 07/23/97
Cage Range: All
Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death
25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88036-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:42:51
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 50 50 50 60
Early Deaths
Moribund Sacrifice 14 7 12 7 6
Natural Death 13 3 3 6 4
Survivors
Terminal Sacrifice 23 40 35 37 40
Animals Examined Microscopically 50 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50) (50) (50)
Intestine Large, Rectum (50) (50) (49) (50) (50)
Leiomyosarcoma 1 (2%)
Intestine Large, Cecum (50) (49) (49) (50) (49)
Intestine Small, Jejunum (50) (50) (50) (50) (49)
Leiomyosarcoma 1 (2%)
Liver (50) (50) (50) (50) (49)
Carcinoma, Metastatic, Islets, Pancreatic 1 (2%)
Fibrous Histiocytoma, Metastatic, Tissue NOS 1 (2%)
Hepatocellular Carcinoma 1 (2%)
Hepatocellular Adenoma 2 (4%) 5 (10%) 3 (6%) 3 (6%)
Hepatocellular Adenoma, Multiple 1 (2%) 1 (2%)
Mesentery (4) (4) (6) (3) (2)
Carcinoma, Metastatic, Islets, Pancreatic 1 (17%)
Carcinoma, Metastatic, Kidney 1 (33%)
Oral Mucosa (1) (1)
Pharyngeal, Squamous Cell Papilloma 1 (100%)
Pancreas (50) (50) (50) (50) (49)
Carcinoma, Metastatic, Islets, Pancreatic 1 (2%)
Salivary Glands (50) (50) (50) (50) (48)
Stomach, Glandular (50) (50) (50) (50) (49)
Tongue (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50) (48)
Carcinoma, Metastatic, Mammary Gland 1 (2%)
Schwannoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 88036-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:42:51
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50) (49)
Adenoma 1 (2%)
Carcinoma, Metastatic, Kidney 1 (2%)
Adrenal Medulla (50) (50) (50) (50) (49)
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma Benign 1 (2%) 1 (2%) 2 (4%)
Islets, Pancreatic (49) (50) (50) (50) (49)
Carcinoma 1 (2%) 1 (2%)
Parathyroid Gland (42) (44) (48) (48) (41)
Pituitary Gland (50) (50) (50) (49) (49)
Squamous Cell Carcinoma, Metastatic, Nose 1 (2%)
Pars Distalis, Adenoma 20 (40%) 22 (44%) 23 (46%) 17 (35%) 19 (39%)
Thyroid Gland (50) (50) (50) (50) (49)
C-Cell, Adenoma 5 (10%) 4 (8%) 5 (10%) 10 (20%) 9 (18%)
C-Cell, Carcinoma 1 (2%)
Follicular Cell, Adenoma 1 (2%) 1 (2%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Fibrous Histiocytoma 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (49) (46) (48) (49) (48)
Adenoma 2 (4%) 2 (4%) 3 (6%) 2 (4%) 1 (2%)
Carcinoma 2 (4%) 1 (2%) 2 (4%)
Bilateral, Adenoma 1 (2%) 1 (2%) 1 (2%)
Ovary (50) (50) (50) (50) (49)
Carcinoma, Metastatic, Kidney 1 (2%)
Granulosa Cell Tumor Malignant 1 (2%)
Granulosa-Theca Tumor Malignant 1 (2%)
Granulosa-Theca Tumor Benign 1 (2%)
Luteoma 1 (2%)
Oviduct (1) (1)
Carcinoma, Metastatic, Islets, Pancreatic 1 (100%)
Uterus (50) (50) (50) (50) (49)
Polyp Stromal 6 (12%) 9 (18%) 9 (18%) 4 (8%) 5 (10%)
Sarcoma Stromal 1 (2%)
Schwannoma Malignant 1 (2%)
Cervix, Leiomyosarcoma 2 (4%)
Cervix, Polyp Stromal 1 (2%)
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 88036-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:42:51
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50) (50)
Lymph Node (10) (1) (1)
Lumbar, Fibrous Histiocytoma, Metastatic,
Tissue NOS 1 (10%)
Mediastinal, Carcinoma, Metastatic, Islets,
Pancreatic 1 (100%)
Mediastinal, Carcinoma, Metastatic, Kidney 1 (100%)
Lymph Node, Mandibular (49) (49) (50) (48) (47)
Lymph Node, Mesenteric (50) (49) (49) (50) (49)
Carcinoma, Metastatic, Kidney 1 (2%)
Spleen (50) (50) (50) (50) (49)
Hemangiosarcoma 1 (2%) 1 (2%) 1 (2%)
Thymus (46) (48) (48) (49) (46)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50) (50)
Adenoma 1 (2%) 1 (2%)
Adenoma, Multiple 1 (2%)
Carcinoma 1 (2%) 1 (2%) 2 (4%) 3 (6%)
Fibroadenoma 19 (38%) 20 (40%) 20 (40%) 18 (36%) 13 (26%)
Fibroadenoma, Multiple 6 (12%) 6 (12%) 6 (12%) 6 (12%) 6 (12%)
Skin (50) (50) (50) (50) (50)
Keratoacanthoma 1 (2%)
Trichoepithelioma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50) (50)
Mandible, Carcinosarcoma, Metastatic,
Zymbal's Gland 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50) (49)
Astrocytoma Malignant 1 (2%) 1 (2%)
Oligodendroglioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 88036-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:42:51
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50) (48)
Alveolar/Bronchiolar Adenoma 1 (2%) 2 (4%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%) 1 (2%)
Carcinoma, Metastatic, Islets, Pancreatic 1 (2%)
Carcinoma, Metastatic, Kidney 1 (2%)
Carcinoma, Metastatic, Mammary Gland 1 (2%)
Carcinosarcoma, Metastatic, Zymbal's Gland 1 (2%)
Squamous Cell Carcinoma, Metastatic, Nose 1 (2%)
Nose (50) (50) (50) (50) (50)
Nasolacrimal Duct, Squamous Cell Carcinoma 1 (2%)
Trachea (50) (50) (50) (50) (49)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1)
Squamous Cell Carcinoma, Metastatic, Nose 1 (100%)
Zymbal's Gland (1) (1)
Carcinoma 1 (100%)
Carcinosarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50) (49)
Carcinoma, Metastatic, Islets, Pancreatic 1 (2%)
Fibrous Histiocytoma, Metastatic, Tissue NOS 1 (2%)
Bilateral, Renal Tubule, Adenoma 1 (2%) 1 (2%)
Renal Tubule, Adenoma 4 (8%) 7 (14%) 6 (12%) 12 (24%)
Renal Tubule, Adenoma, Multiple 1 (2%)
Renal Tubule, Carcinoma 2 (4%) 1 (2%) 2 (4%)
Renal Tubule, Carcinoma, Metastatic, Kidney 1 (2%)
Urinary Bladder (49) (49) (49) (50) (49)
Transitional Epithelium, Carcinoma 1 (2%)
Transitional Epithelium, Papilloma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50) *(50)
Leukemia Mononuclear 18 (36%) 1 (2%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 88036-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:42:51
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 46 46 47 42 45
Total Primary Neoplasms 91 83 98 80 86
Total Animals with Benign Neoplasms 39 45 44 40 41
Total Benign Neoplasms 64 74 87 71 75
Total Animals with Malignant Neoplasms 24 9 11 9 10
Total Malignant Neoplasms 27 9 11 9 11
Total Animals with Metastatic Neoplasms 2 2 1 2
Total Metastatic Neoplasm 5 10 6 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
NTP Experiment-Test: 88036-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:42:51
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 50 50 50 60
Early Deaths
Moribund Sacrifice 21 21 16 14 17
Natural Death 7 6 12 10 11
Survivors
Terminal Sacrifice 21 23 22 26 22
Natural Death 1
Animals Examined Microscopically 50 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50) (50) (49)
Fibrosarcoma, Metastatic, Salivary Glands 1 (2%)
Intestine Small, Duodenum (50) (50) (50) (50) (50)
Intestine Small, Jejunum (50) (50) (50) (50) (50)
Intestine Small, Ileum (50) (50) (50) (50) (50)
Liver (50) (50) (50) (50) (50)
Hepatocellular Carcinoma 1 (2%) 1 (2%)
Hepatocellular Adenoma 1 (2%) 3 (6%) 4 (8%) 3 (6%) 2 (4%)
Hepatocellular Adenoma, Multiple 1 (2%)
Histiocytic Sarcoma 1 (2%)
Mesentery (10) (4) (6) (7) (6)
Fibrosarcoma, Metastatic, Skin 1 (17%)
Oral Mucosa (1) (2) (1)
Squamous Cell Carcinoma 1 (100%)
Squamous Cell Papilloma 1 (100%) 1 (50%)
Pancreas (50) (50) (50) (50) (50)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Acinus, Adenoma 1 (2%)
Salivary Glands (50) (50) (48) (50) (47)
Fibrosarcoma 1 (2%)
Schwannoma Malignant 1 (2%) 1 (2%)
Stomach, Forestomach (50) (50) (50) (50) (50)
Squamous Cell Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 88036-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:42:51
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50) (50)
Schwannoma Malignant 1 (2%)
Adrenal Medulla (50) (50) (50) (50) (50)
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 6 (12%) 7 (14%) 10 (20%) 6 (12%) 10 (20%)
Bilateral, Pheochromocytoma Benign 2 (4%) 1 (2%) 1 (2%)
Islets, Pancreatic (49) (50) (50) (50) (50)
Adenoma 1 (2%) 2 (4%)
Carcinoma 1 (2%) 1 (2%)
Parathyroid Gland (49) (48) (48) (50) (45)
Adenoma 1 (2%) 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 2 (4%)
Pituitary Gland (50) (50) (49) (50) (50)
Pars Distalis, Adenoma 15 (30%) 15 (30%) 11 (22%) 11 (22%) 9 (18%)
Thyroid Gland (50) (50) (48) (50) (47)
Fibrosarcoma, Metastatic, Salivary Glands 1 (2%)
Schwannoma Malignant, Metastatic, Salivary
Glands 1 (2%)
Bilateral, C-Cell, Adenoma 1 (2%) 1 (2%)
C-Cell, Adenoma 2 (4%) 6 (12%) 6 (13%) 6 (12%) 3 (6%)
C-Cell, Carcinoma 2 (4%)
Follicular Cell, Adenoma 1 (2%) 4 (8%) 1 (2%) 1 (2%)
Follicular Cell, Carcinoma 1 (2%) 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Chemodectoma Benign 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50) (50)
Preputial Gland (50) (49) (50) (49) (50)
Adenoma 3 (6%) 8 (16%) 7 (14%) 4 (8%) 2 (4%)
Carcinoma 1 (2%) 1 (2%) 2 (4%) 5 (10%) 3 (6%)
Bilateral, Adenoma 1 (2%)
Prostate (50) (50) (50) (50) (50)
Seminal Vesicle (50) (50) (50) (49) (50)
Testes (50) (50) (50) (50) (50)
Interstitial Cell, Adenoma 6 (12%) 5 (10%) 3 (6%) 3 (6%) 4 (8%)
Interstitial Cell, Adenoma, Multiple 40 (80%) 41 (82%) 44 (88%) 44 (88%) 44 (88%)
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 88036-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:42:51
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50) (50)
Lymph Node (8) (3) (1) (1) (2)
Mediastinal, Histiocytic Sarcoma 1 (100%)
Lymph Node, Mandibular (50) (50) (47) (50) (47)
Fibrosarcoma, Metastatic, Salivary Glands 1 (2%)
Schwannoma Malignant, Metastatic, Salivary
Glands 1 (2%)
Lymph Node, Mesenteric (50) (49) (50) (50) (49)
Spleen (50) (50) (50) (50) (50)
Fibroma 1 (2%)
Fibrosarcoma 1 (2%) 1 (2%)
Hemangiosarcoma 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Thymus (46) (44) (45) (46) (41)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (45) (47) (46) (50) (47)
Fibroadenoma 1 (2%) 5 (11%) 7 (14%) 4 (9%)
Fibroadenoma, Multiple 1 (2%) 1 (2%)
Skin (50) (50) (50) (50) (50)
Basal Cell Adenoma 1 (2%) 1 (2%)
Keratoacanthoma 2 (4%) 3 (6%) 2 (4%) 5 (10%)
Squamous Cell Papilloma 1 (2%) 2 (4%)
Trichoepithelioma 1 (2%)
Sebaceous Gland, Adenoma 1 (2%)
Subcutaneous Tissue, Fibroma 5 (10%) 4 (8%) 1 (2%) 5 (10%) 2 (4%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Histiocytic Sarcoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Melanoma Malignant 3 (6%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50) (50)
Osteosarcoma 1 (2%)
Maxilla, Osteosarcoma 1 (2%)
Tibia, Chondroma 1 (2%)
Skeletal Muscle (1)
Osteosarcoma, Metastatic, Bone 1 (100%)
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 88036-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:42:51
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50) (50)
Astrocytoma Malignant 2 (4%)
Histiocytic Sarcoma 1 (2%)
Meningioma Malignant 1 (2%)
Oligodendroglioma Malignant 1 (2%)
Spinal Cord (1) (2)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 2 (4%) 2 (4%) 2 (4%)
Carcinoma, Metastatic, Preputial Gland 1 (2%)
Chordoma, Metastatic, Uncertain Primary Site 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (2%)
Nose (50) (50) (50) (50) (50)
Respiratory Epithelium, Adenoma 1 (2%)
Respiratory Epithelium, Papilloma 1 (2%)
Trachea (50) (50) (50) (50) (49)
Fibrosarcoma, Metastatic, Salivary Glands 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (2)
Carcinoma 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50) (50)
Bilateral, Renal Tubule, Adenoma 1 (2%)
Renal Tubule, Adenoma 1 (2%) 3 (6%) 8 (16%) 5 (10%) 3 (6%)
Renal Tubule, Oncocytoma Benign 1 (2%)
Transitional Epithelium, Papilloma 2 (4%) 1 (2%)
Urinary Bladder (50) (50) (50) (50) (49)
Transitional Epithelium, Papilloma 1 (2%) 3 (6%) 7 (14%) 3 (6%)
NTP Experiment-Test: 88036-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:42:51
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 25 (50%) 2 (4%) 1 (2%) 5 (10%) 7 (14%)
Mesothelioma Malignant 4 (8%) 4 (8%) 5 (10%) 4 (8%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 11
NTP Experiment-Test: 88036-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:42:51
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 50 50 50 49
Total Primary Neoplasms 129 121 131 138 114
Total Animals with Benign Neoplasms 50 50 48 50 48
Total Benign Neoplasms 94 105 114 112 99
Total Animals with Malignant Neoplasms 30 13 15 18 14
Total Malignant Neoplasms 35 16 17 23 15
Total Animals with Metastatic Neoplasms 1 6 1 3
Total Metastatic Neoplasm 1 10 1 4
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 3
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------