TDMS Study 88036-03 Pathology Tables
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
2 YEAR CHRONIC RATS
Facility: Battelle Columbus Laboratory
Chemical CAS #: 84-65-1
Lock Date: 07/23/97
Cage Range: All
Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death
25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 6| 5| 6| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 3| 5| 3| 3| 7| 0| 1| 5| 3| 1| 3| 1| 0| 1| 4| 3| 7| 8| 3| 3| 6| 3| 4| 3| 0|
| 0| 0| 1| 2| 6| 2| 8| 2| 2| 8| 1| 3| 4| 7| 5| 5| 1| 1| 2| 0| 2| 1| 5| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
0 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X |
Clear Cell Focus | |
Eosinophilic Focus | X X X |
Fatty Change | 2 |
Hematopoietic Cell Proliferation | 1 1 |
Hepatodiaphragmatic Nodule | X X |
Inflammation | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Mixed Cell Focus | X |
Necrosis | 1 1 |
Thrombosis | |
Vacuolization Cytoplasmic | 3 2|
Bile Duct, Hyperplasia | 1 1 1 3 1 1 1 1|
Centrilobular, Degeneration | 3 |
__________________________________________________________________________|
Mesentery | +|
Fat, Necrosis | |
__________________________________________________________________________|
Oral Mucosa | + |
Gingival, Inflammation | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 1 2 1 1 1 1 3 1 1 1 1 |
Hyperplasia | 1 1 |
Hypertrophy, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Hyperplasia | 4 2 |
Inflammation | 4 |
Necrosis | |
Ulcer | 3 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Ulcer | 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 6| 5| 6| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 3| 5| 3| 3| 7| 0| 1| 5| 3| 1| 3| 1| 0| 1| 4| 3| 7| 8| 3| 3| 6| 3| 4| 3| 0|
| 0| 0| 1| 2| 6| 2| 8| 2| 2| 8| 1| 3| 4| 7| 5| 5| 1| 1| 2| 0| 2| 1| 5| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
0 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 |
Inflammation | 1 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 1 1 |
Hematopoietic Cell Proliferation | |
Hyperplasia | 1 1 1 1 1 2 1|
Hypertrophy | |
Mineralization | 2 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + M + M + + + M + + M + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Cyst | 1 1 2 3 |
Degeneration | |
Pars Distalis, Hyperplasia | 2 2 1 1 1 2 3 2 1 4 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation | 1 3 1 1 |
Duct, Cyst | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 4 2 |
Granulosa Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
__________________________________________________________________________|
Vagina | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 6| 5| 6| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 3| 5| 3| 3| 7| 0| 1| 5| 3| 1| 3| 1| 0| 1| 4| 3| 7| 8| 3| 3| 6| 3| 4| 3| 0|
| 0| 0| 1| 2| 6| 2| 8| 2| 2| 8| 1| 3| 4| 7| 5| 5| 1| 1| 2| 0| 2| 1| 5| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
0 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | 4 2 2 2 3 2 2 3 2|
__________________________________________________________________________|
Lymph Node | + + + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + +|
Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Ectasia | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis | |
Hematopoietic Cell Proliferation | 1 2 3 2 1 1 2 2 1 1 1 2 1 1 2 1 3 2 1|
Infarct | 2 |
Pigmentation | 3 1 1 2 1 1 1 2 1 1 1 2 1 1|
Capsule, Fibrosis | 1 1 |
Lymphoid Follicle, Atrophy | |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + M + + M + + + + + +|
Atrophy | 3 3 3 4 4 3 4 4 3 4 4 2 4 3 3 4 4 3 3 3 4 3|
Artery, Inflammation | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 3 |
Hyperplasia | 1 2 1 1 2 2 1 2 3 1 2 1 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3|
Subcutaneous Tissue, Necrosis | 3|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 2 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 1 1 1 1 |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 6| 5| 6| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 3| 5| 3| 3| 7| 0| 1| 5| 3| 1| 3| 1| 0| 1| 4| 3| 7| 8| 3| 3| 6| 3| 4| 3| 0|
| 0| 0| 1| 2| 6| 2| 8| 2| 2| 8| 1| 3| 4| 7| 5| 5| 1| 1| 2| 0| 2| 1| 5| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
0 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Thrombosis | 1 |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Inflammation | 1 |
Nasolacrimal Duct, Inflammation | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
Cornea, Inflammation | |
Retina, Degeneration | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 2 |
Infarct | |
Inflammation | 1 1 |
Nephropathy | 1 1 1 1 1 1 1 2 1 1 2 1 1 1 1 1 1 2 1|
Pigmentation | 2 1 1 1 2 1 3 1 1 1 1|
Medulla, Mineralization | 1 1 1 1 1 1 1 1 1 1 1|
Pelvis, Calculus Micro Observation | |
Only | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| |
DAY ON TEST | 6| 1| 3| 3| 6| 3| 3| 1| 0| 4| 3| 3| 7| 1| 3| 3| 3| 3| 3| 3| 7| 3| 8| 7| 3| |
| 6| 8| 2| 0| 5| 2| 2| 7| 5| 9| 1| 1| 6| 5| 1| 0| 1| 0| 2| 1| 1| 2| 9| 5| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X X | 6 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 3 1.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X| 37 |
Clear Cell Focus | X | 1 |
Eosinophilic Focus | X X X X X| 8 |
Fatty Change | | 1 2.0|
Hematopoietic Cell Proliferation | 2 | 3 1.3|
Hepatodiaphragmatic Nodule | X X X | 5 |
Inflammation | 1 1 1 1 2 1 1 1 1 1 1 1 | 25 1.0|
Mixed Cell Focus | X X| 3 |
Necrosis | 1 1 | 4 1.0|
Thrombosis | 2 | 1 2.0|
Vacuolization Cytoplasmic | 4 1 2 | 5 2.4|
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 | 17 1.1|
Centrilobular, Degeneration | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 4 |
Fat, Necrosis | 3 3 2 | 3 2.7|
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
Gingival, Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 2 1 1 2 1 1 1 | 21 1.2|
Hyperplasia | | 2 1.0|
Hypertrophy, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 1 | 1 1.0|
Hyperplasia | 2 2 | 4 2.5|
Inflammation | | 1 4.0|
Necrosis | 2 | 1 2.0|
Ulcer | 4 1 1 | 6 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| |
DAY ON TEST | 6| 1| 3| 3| 6| 3| 3| 1| 0| 4| 3| 3| 7| 1| 3| 3| 3| 3| 3| 3| 7| 3| 8| 7| 3| |
| 6| 8| 2| 0| 5| 2| 2| 7| 5| 9| 1| 1| 6| 5| 1| 0| 1| 0| 2| 1| 1| 2| 9| 5| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 1 | 2 1.5|
Ulcer | | 2 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 2 1 1 1 1 1 1 1| 22 1.0|
Inflammation | 1| 2 1.0|
Atrium, Thrombosis | 3 1 | 2 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 1 1 | 6 1.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia | 1 1 1 1 1 1 | 13 1.1|
Hypertrophy | 2 1 1 | 3 1.3|
Mineralization | | 1 2.0|
Vacuolization Cytoplasmic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 4 2 1 4 | 8 1.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + M + + + M + + M| 42 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 4.0|
Cyst | 3 1 1 1 3 | 9 1.8|
Degeneration | 1 | 1 1.0|
Pars Distalis, Hyperplasia | 1 2 3 2 2 4 4 4 2 2 1 4 2 | 24 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 1 2 2 1 1 4| 21 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| |
DAY ON TEST | 6| 1| 3| 3| 6| 3| 3| 1| 0| 4| 3| 3| 7| 1| 3| 3| 3| 3| 3| 3| 7| 3| 8| 7| 3| |
| 6| 8| 2| 0| 5| 2| 2| 7| 5| 9| 1| 1| 6| 5| 1| 0| 1| 0| 2| 1| 1| 2| 9| 5| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia | 4 3| 2 3.5|
Inflammation | 1 1 1 1 4 2| 10 1.6|
Duct, Cyst | 4 4 4 | 4 3.8|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 1 4 | 5 2.8|
Granulosa Cell, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Vagina | + | 1 |
Inflammation, Suppurative | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 1 1 | 4 1.0|
Hyperplasia | 1 2 2 2 3 1 2 1 3 2 | 19 2.2|
__________________________________________________________________________|____________|
Lymph Node | + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ectasia | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 1 3.0|
Ectasia | | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 | 1 2.0|
Fibrosis | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 2 1 1 1 1 1 1 1 2 1 3 1 2 2 1 1 2 2 1 1| 39 1.5|
Infarct | | 1 2.0|
Pigmentation | 2 1 1 3 1 1 1 2 2 2 3 2 2 2 2 2 2 2 1| 33 1.6|
Capsule, Fibrosis | | 2 1.0|
Lymphoid Follicle, Atrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + M + + + + + + + + + + +| 46 |
Atrophy | 4 3 4 3 4 4 4 4 4 3 4 3 3 4 3 3 3 3 3 3 3 3| 44 3.4|
Artery, Inflammation | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 1 3 | 5 2.2|
Hyperplasia | 3 3 1 4 1 3 2 1 2 3 | 23 1.9|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| |
DAY ON TEST | 6| 1| 3| 3| 6| 3| 3| 1| 0| 4| 3| 3| 7| 1| 3| 3| 3| 3| 3| 3| 7| 3| 8| 7| 3| |
| 6| 8| 2| 0| 5| 2| 2| 7| 5| 9| 1| 1| 6| 5| 1| 0| 1| 0| 2| 1| 1| 2| 9| 5| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Subcutaneous Tissue, Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteopetrosis | 2 | 3 2.3|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 | 1 1.0|
Inflammation | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 1 4 1 1 1 | 13 1.2|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 44 1.0|
Thrombosis | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 1 1| 3 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X X X | 4 |
Inflammation | 2 1 1 | 4 1.3|
Nasolacrimal Duct, Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 2 |
Cataract | 2 3 | 2 2.5|
Cornea, Inflammation | 4 | 1 4.0|
Retina, Degeneration | 2 | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 33 1.1|
Infarct | 2 | 1 2.0|
Inflammation | 2 | 3 1.3|
Nephropathy | 1 1 2 1 1 1 1 1 1 1 1 1 2 2 1 1 1 1 1 1| 39 1.2|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3 1| 27 1.2|
Medulla, Mineralization | 1 1 1 1 1 1| 17 1.0|
Pelvis, Calculus Micro Observation | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| |
DAY ON TEST | 6| 1| 3| 3| 6| 3| 3| 1| 0| 4| 3| 3| 7| 1| 3| 3| 3| 3| 3| 3| 7| 3| 8| 7| 3| |
| 6| 8| 2| 0| 5| 2| 2| 7| 5| 9| 1| 1| 6| 5| 1| 0| 1| 0| 2| 1| 1| 2| 9| 5| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Only | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
Inflammation | 1 1 1 1 1 | 13 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| 3| 8| 3| 3| 3|
| 5| 0| 1| 0| 0| 2| 1| 0| 1| 1| 0| 2| 0| 1| 2| 2| 0| 2| 1| 9| 1| 9| 2| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
469 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 1 2 1 1 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X |
Degeneration, Cystic | 1 |
Eosinophilic Focus | X X X X X X X X X X X X X X X X X|
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X X X X X |
Inflammation | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 2 1 1 |
Mixed Cell Focus | X X X X X X X X X X X X X X X X |
Necrosis | 1 1 1 1 |
Thrombosis | 1 |
Vacuolization Cytoplasmic | 1 |
Bile Duct, Cyst | 2 |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1|
Centrilobular, Degeneration | |
Centrilobular, Hypertrophy | 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 1 1 1 1 1 1 1 1 1 1 1|
Hyperplasia | 1 |
Hypertrophy, Focal | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Fibrosis | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| 3| 8| 3| 3| 3|
| 5| 0| 1| 0| 0| 2| 1| 0| 1| 1| 0| 2| 0| 1| 2| 2| 0| 2| 1| 9| 1| 9| 2| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
469 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation | 1 1 1 |
Artery, Inflammation | 2 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
Hyperplasia | 1 3 1 1 1|
Hypertrophy | 1 |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + M + + + + + M + + + M + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 3 2 3 |
Cyst | 1 1 |
Pars Distalis, Hyperplasia | 2 3 1 3 3 1 2 4 3 3 1|
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 4 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + + + M + + + + + + + + + + + M + + + + +|
Hyperplasia | 4 3 |
Inflammation | 1 1 1 1 1 1 1 1 1 |
Duct, Cyst | 1 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 3 2 4 |
Granulosa Cell, Hyperplasia | |
Interstitial Cell, Hyperplasia | |
__________________________________________________________________________|
Oviduct | |
Inflammation | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| 3| 8| 3| 3| 3|
| 5| 0| 1| 0| 0| 2| 1| 0| 1| 1| 0| 2| 0| 1| 2| 2| 0| 2| 1| 9| 1| 9| 2| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
469 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Atrophy | 1 1 1 2 1 1 1 |
Hyperplasia | 3 1 2 1 2 2 2 2 3 1 3 2 3 1 1 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M + + + + +|
Atrophy | |
Ectasia | |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 2 2 2 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1|
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 1 2 2 2 2 2 2|
Pigmentation | 3 2 1 2 2 2 2 2 1 2 1 2 2 2 2 2 1 2 1 2 3 2 1 2|
Red Pulp, Depletion Cellular | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + M + + + + +|
Atrophy | 2 3 4 3 3 3 3 3 3 4 3 4 3 2 2 3 3 3 3 3 4 3 4 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 4 |
Hyperplasia | 1 2 |
Inflammation | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hair Follicle, Atrophy | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 1 1 1 1 1 |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Alveolar Epithelium, Hyperplasia | 2 1 4 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Inflammation | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| 3| 8| 3| 3| 3|
| 5| 0| 1| 0| 0| 2| 1| 0| 1| 1| 0| 2| 0| 1| 2| 2| 0| 2| 1| 9| 1| 9| 2| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
469 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Cataract | |
Lens, Mineralization | |
Retina, Degeneration | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | 1 1 3 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1 1 2|
Nephropathy | 2 1 2 1 1 2 1 1 2 2 1 1 2 1 1 2 1 2 1 1 1 1 1 1 1|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 2 1 1 1 1|
Medulla, Mineralization | 1 1 1 1 1 1 1 1 1 1 |
Pelvis, Inflammation | |
Renal Tubule, Hyperplasia | 1 1 1 1 1 1 |
Renal Tubule, Hyperplasia, Oncocytic | 1 |
Transitional Epithelium, Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + M + + + + +|
Inflammation | 1 1 1 1 1 1 |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 0| 3| 1| 4| 3| 3| 3| 3| 3| 3| 3| 4| 3| 9| 3| 3| 3| 1| 3| 3| 3| 3| |
| 0| 2| 0| 6| 0| 3| 7| 1| 2| 0| 0| 1| 1| 2| 5| 2| 4| 2| 2| 2| 8| 1| 2| 0| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
469 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X X| 11 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 3 1 1 1 1 1 1 1| 15 1.2|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X X X| 50 |
Clear Cell Focus | | 3 |
Degeneration, Cystic | 1 1 1 1 | 5 1.0|
Eosinophilic Focus | X X X X X X X X X X X X X X X| 32 |
Hematopoietic Cell Proliferation | | 1 1.0|
Hepatodiaphragmatic Nodule | X X X X X | 10 |
Inflammation | 1 1 1 1 2 2 1 2 1 1 1 1 2 3 1 1 2 1 1 1 1 1 1| 46 1.2|
Mixed Cell Focus | X X X X X X X X X X X X X X| 30 |
Necrosis | | 4 1.0|
Thrombosis | | 1 1.0|
Vacuolization Cytoplasmic | 1 1 1| 4 1.0|
Bile Duct, Cyst | | 1 2.0|
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1| 22 1.0|
Centrilobular, Degeneration | 4 | 1 4.0|
Centrilobular, Hypertrophy | 1 1 1 1 1 1 | 18 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 4 |
Fat, Necrosis | 2 3 3 | 4 2.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 27 1.0|
Hyperplasia | | 1 1.0|
Hypertrophy, Focal | 1 | 2 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 | 1 1.0|
Fibrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 1 3.0|
Inflammation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 0| 3| 1| 4| 3| 3| 3| 3| 3| 3| 3| 4| 3| 9| 3| 3| 3| 1| 3| 3| 3| 3| |
| 0| 2| 0| 6| 0| 3| 7| 1| 2| 0| 0| 1| 1| 2| 5| 2| 4| 2| 2| 2| 8| 1| 2| 0| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
469 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Erosion | 1 | 1 1.0|
Ulcer | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1| 25 1.0|
Inflammation | 1 1 1 1 1 1 | 9 1.0|
Artery, Inflammation | | 2 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 1 2 | 2 1.5|
Hyperplasia | 1 1 1 1 1 1 1 | 12 1.2|
Hypertrophy | | 1 1.0|
Vacuolization Cytoplasmic | 1 | 2 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 3 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + M + + + + +| 44 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 4 3 2 4 3 2 2 4 | 12 2.9|
Cyst | 2 2 3 2 1| 7 1.7|
Pars Distalis, Hyperplasia | 2 4 4 1 1 2 3 2 2 1 2 4 4 4 1 4| 27 2.5|
Pars Intermedia, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 2 1 1 2 1 2 1 1 2 1 1 1 2 1 1 2| 29 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| 46 |
Hyperplasia | 1 4 1| 5 2.6|
Inflammation | 1 1 1 1 1 1 1 1 1 1 1 1 | 21 1.0|
Duct, Cyst | 1 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 3 3 2 | 8 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 0| 3| 1| 4| 3| 3| 3| 3| 3| 3| 3| 4| 3| 9| 3| 3| 3| 1| 3| 3| 3| 3| |
| 0| 2| 0| 6| 0| 3| 7| 1| 2| 0| 0| 1| 1| 2| 5| 2| 4| 2| 2| 2| 8| 1| 2| 0| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
469 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Granulosa Cell, Hyperplasia | 3 | 1 3.0|
Interstitial Cell, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Oviduct | + | 1 |
Inflammation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4 | 1 4.0|
Hyperplasia | 1 | 3 1.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 1 2 1 3 1 | 13 1.5|
Hyperplasia | 1 2 3 2 2 3 2 3 1 4 3 2 1 1 2 | 31 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 3 | 1 3.0|
Ectasia | 2 | 1 2.0|
Hyperplasia, Plasma Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 1 2 2 1 2 2 2 1 1 2 1 2 2 2 2 1 2 1 2 2 2 2| 46 1.4|
Hematopoietic Cell Proliferation | 1 2 2 2 2 2 2 2 2 2 2 1 2 2 4 1 2 2 2 2 2 2 2 2 2| 50 1.9|
Pigmentation | 1 1 2 1 2 2 1 1 2 2 1 1 2 2 2 2 1 2 2 2 2| 45 1.7|
Red Pulp, Depletion Cellular | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 |
Atrophy | 4 3 3 3 4 2 4 4 4 4 3 3 4 2 3 3 3 3 3 4 4 3 3 3| 48 3.2|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 | 3 3.3|
Hyperplasia | 1 2 1 2 1 4| 8 1.8|
Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hair Follicle, Atrophy | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteopetrosis | 4 | 2 3.5|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 0| 3| 1| 4| 3| 3| 3| 3| 3| 3| 3| 4| 3| 9| 3| 3| 3| 1| 3| 3| 3| 3| |
| 0| 2| 0| 6| 0| 3| 7| 1| 2| 0| 0| 1| 1| 2| 5| 2| 4| 2| 2| 2| 8| 1| 2| 0| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
469 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 1 1 1 1 1 1 1 1 1 | 18 1.0|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 50 1.0|
Alveolar Epithelium, Hyperplasia | 1 1 2 | 7 1.7|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 |
Inflammation | 1 | 2 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 3 |
Cataract | 2 2 2 | 3 2.0|
Lens, Mineralization | 2 1 | 2 1.5|
Retina, Degeneration | 2 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | 1 1 2 1 3 1 1 1 1 2 1 1 1 1 1 1 2 1 1 1 1 1 1| 48 1.2|
Nephropathy | 1 3 1 1 1 3 1 2 2 2 1 3 2 1 1 1 1 1 1 1 1 1 1 1| 49 1.4|
Pigmentation | 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1| 50 1.1|
Medulla, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 25 1.0|
Pelvis, Inflammation | 2 | 1 2.0|
Renal Tubule, Hyperplasia | 1 4 2 2 1 1| 12 1.4|
Renal Tubule, Hyperplasia, Oncocytic | 1 | 2 1.0|
Transitional Epithelium, Hyperplasia | 1 1 | 5 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation | 1 1 1 1 1 1 1 1 1 1| 16 1.0|
Transitional Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 5| 7| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|
| 0| 8| 1| 2| 1| 1| 2| 1| 3| 0| 5| 1| 1| 8| 0| 1| 0| 0| 2| 2| 2| 0| 2| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
938 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + M + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + M + + + + + + + + + + +|
Inflammation | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + M + + + + + + + + + + +|
Cyst | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 1 1 1 1 1 1 1 1 1 1 2 1|
Basophilic Focus | X X X X X X X X X X X X X X X X X X |
Clear Cell Focus | X |
Degeneration, Cystic | 2 2 1 1|
Eosinophilic Focus | X X X X X X X X X X X X X X X X X X X|
Hepatodiaphragmatic Nodule | X X X |
Inflammation | 1 2 3 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 2|
Mixed Cell Focus | X X X X X X X X X |
Necrosis | 1 1 |
Vacuolization Cytoplasmic | 1 |
Bile Duct, Cholangiofibrosis | 2 |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 1|
Centrilobular, Degeneration | 1 |
Centrilobular, Hypertrophy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Mesentery | + + + + |
Inflammation | |
Fat, Necrosis | 3 3 3 |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 1 1 3 1 1 |
Pigmentation | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Foreign Body | |
Hyperplasia | 3 |
Inflammation | |
Ulcer | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Erosion | 1 |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 5| 7| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|
| 0| 8| 1| 2| 1| 1| 2| 1| 3| 0| 5| 1| 1| 8| 0| 1| 0| 0| 2| 2| 2| 0| 2| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
938 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation | 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1 2 2 |
Hyperplasia | 1 1 1 1 1 1 1 1 1 1 |
Hypertrophy | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Cyst | 1 |
Pars Distalis, Hyperplasia | 4 2 3 1 2 1 1 2 3 1 1 1 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 2 1 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia | 2 2 3 2 |
Inflammation | 1 1 1 1 1 |
Duct, Cyst | 1 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 1 |
__________________________________________________________________________|
Oviduct | + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hemorrhage | 4 |
Hyperplasia | |
Cervix, Inflammation | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 5| 7| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|
| 0| 8| 1| 2| 1| 1| 2| 1| 3| 0| 5| 1| 1| 8| 0| 1| 0| 0| 2| 2| 2| 0| 2| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
938 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Atrophy | 3 2 1 1 1 1 |
Hyperplasia | 2 1 1 2 4 2 1 1 1 2 2 1 4|
Infiltration Cellular, Histiocyte | 2 |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
Hyperplasia, Plasma Cell | 4 |
Inflammation | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + M + + + + + + + + + + +|
Ectasia | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 2 2 1 2 2 2 2 1 2 2 2 1 2 2 2 2 1 2 2 2|
Hematopoietic Cell Proliferation | 2 1 2 2 1 2 2 2 1 1 2 4 2 2 2 2 2 2 2 1 2 2 2|
Pigmentation | 2 3 2 2 2 1 2 2 3 2 2 1 4 1 1 2 1 2 1 1 1 2 1 1|
Capsule, Fibrosis | 1 |
Lymphoid Follicle, Atrophy | 3 |
Red Pulp, Depletion Cellular | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + M + + + + M + + + +|
Atrophy | 3 4 4 4 3 4 4 3 4 3 3 4 4 4 4 3 3 3 3 4 4 4 4|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 2 3 |
Hyperplasia | 3 2 1 3 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 |
Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Thrombosis | 1 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 1 1 1 1|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 5| 7| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|
| 0| 8| 1| 2| 1| 1| 2| 1| 3| 0| 5| 1| 1| 8| 0| 1| 0| 0| 2| 2| 2| 0| 2| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
938 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Foreign Body | |
Inflammation | 2 |
Respiratory Epithelium, Inflammation | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 3 |
Degeneration | 4 |
Inflammation | 2 |
Lens, Mineralization | 3 |
Retina, Degeneration | 3 4 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | 1 1 2 2 2 1 1 1 1 1 2 2 1 2 2 1 1 1 1 1 1 1|
Hydronephrosis | 2 |
Infarct | 1 |
Nephropathy | 1 1 1 1 2 1 2 1 1 1 1 1 1 2 1 2 2 1 1 4 1 3 1|
Pigmentation | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2|
Medulla, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Pelvis, Inflammation | 1 |
Renal Tubule, Hyperplasia | 1 2 1 1 2 2 |
Transitional Epithelium, Hyperplasia | 2 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + M + + + + + + + + + + +|
Inflammation | 1 1 1 1 1|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 0| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 7| 3| 3| 2| 3| 8| 7| 3| 5| 3| 3| 3| 0| 2| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3| |
| 1| 1| 0| 1| 3| 0| 5| 0| 0| 2| 1| 1| 1| 3| 5| 2| 2| 0| 0| 1| 0| 3| 6| 0| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
938 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation | 2 | 1 2.0|
Parasite Metazoan | X X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 2 1 2 | 18 1.2|
Basophilic Focus | X X X X X X X X X X X X X X X X | 34 |
Clear Cell Focus | X | 2 |
Degeneration, Cystic | 1 1 1 1 1 1 | 10 1.2|
Eosinophilic Focus | X X X X X X X X X X X X X X X| 34 |
Hepatodiaphragmatic Nodule | X X X X | 7 |
Inflammation | 1 1 1 1 2 1 2 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1| 44 1.2|
Mixed Cell Focus | X X X X X X X X X X X | 20 |
Necrosis | 1 1 1 | 5 1.0|
Vacuolization Cytoplasmic | 1 3 1 1 1 | 6 1.3|
Bile Duct, Cholangiofibrosis | | 1 2.0|
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 1| 20 1.0|
Centrilobular, Degeneration | | 1 1.0|
Centrilobular, Hypertrophy | 1 1 2 1 1 1 1 2 | 23 1.1|
__________________________________________________________________________|____________|
Mesentery | + +| 6 |
Inflammation | 2 | 1 2.0|
Fat, Necrosis | 2| 4 2.8|
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 2 4 1 1 3 1 2 | 16 1.6|
Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 3.0|
Foreign Body | X | 1 |
Hyperplasia | 3 | 2 3.0|
Inflammation | 1 2 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 0| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 7| 3| 3| 2| 3| 8| 7| 3| 5| 3| 3| 3| 0| 2| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3| |
| 1| 1| 0| 1| 3| 0| 5| 0| 0| 2| 1| 1| 1| 3| 5| 2| 2| 0| 0| 1| 0| 3| 6| 0| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
938 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 2.0|
Erosion | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Inflammation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 2 1 1 1 1 1 1 1 1 | 27 1.0|
Inflammation | 1 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 1 1 | 6 1.5|
Hyperplasia | 1 2 3 4 1 1 1 | 17 1.4|
Hypertrophy | 1 | 1 1.0|
Vacuolization Cytoplasmic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 1 1 4 | 4 2.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 2 2.0|
Cyst | 1 2 | 3 1.3|
Pars Distalis, Hyperplasia | 2 2 4 3 4 3 4 4| 21 2.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 2 1 1 1 1 2 1| 20 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 |
Hyperplasia | 2 2 1 1 | 8 1.9|
Inflammation | 1 1 1 1 1 1 1 1 | 13 1.0|
Duct, Cyst | | 2 2.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 0| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 7| 3| 3| 2| 3| 8| 7| 3| 5| 3| 3| 3| 0| 2| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3| |
| 1| 1| 0| 1| 3| 0| 5| 0| 0| 2| 1| 1| 1| 3| 5| 2| 2| 0| 0| 1| 0| 3| 6| 0| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
938 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Cyst | 1 4 3 3 4 4 4| 9 3.0|
__________________________________________________________________________|____________|
Oviduct | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 1 1.0|
Hemorrhage | | 1 4.0|
Hyperplasia | 1 3 2 | 3 2.0|
Cervix, Inflammation | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 2 1 1 2 1 1 | 13 1.4|
Hyperplasia | 3 2 2 4 2 2 2 3 1 2 2 3 3 1 1 | 28 2.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 1 | 2 2.0|
Hyperplasia, Plasma Cell | | 1 4.0|
Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ectasia | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 2 2 2 1 1 2 2 2 1 1 2 1 1 2 1 1 2 1 2 2| 42 1.7|
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 1 1 2 2 1 1 2 2 2 2 2 2 2 2 2 1 1 1| 47 1.8|
Pigmentation | 2 2 2 2 1 3 4 1 2 2 2 2 2 2 1 2 1 2 2 1 2 2 2 2| 48 1.8|
Capsule, Fibrosis | | 1 1.0|
Lymphoid Follicle, Atrophy | 3 | 2 3.0|
Red Pulp, Depletion Cellular | 2 | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | 4 2 3 3 3 3 4 4 4 4 4 4 3 3 3 4 3 2 3 3 3 2 3 4| 47 3.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 4 2.8|
Hyperplasia | 3 2 1 2 2 2 | 11 2.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 0| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 7| 3| 3| 2| 3| 8| 7| 3| 5| 3| 3| 3| 0| 2| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3| |
| 1| 1| 0| 1| 3| 0| 5| 0| 0| 2| 1| 1| 1| 3| 5| 2| 2| 0| 0| 1| 0| 3| 6| 0| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
938 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Osteopetrosis | 2 3 1 | 3 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
Thrombosis | | 1 1.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 1 4 1 1 1 1 1 1 1 1 1| 19 1.2|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 48 1.0|
Alveolar Epithelium, Hyperplasia | 1 3 | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X | 1 |
Inflammation | | 1 2.0|
Respiratory Epithelium, Inflammation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Cataract | | 1 3.0|
Degeneration | | 1 4.0|
Inflammation | | 1 2.0|
Lens, Mineralization | | 1 3.0|
Retina, Degeneration | | 2 3.5|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | 2 2 2 2 1 1 2 1 2 1 1 1 1 2 2 2 2 1 1 2 1 1 1| 45 1.4|
Hydronephrosis | 2 | 2 2.0|
Infarct | | 1 1.0|
Nephropathy | 1 1 2 1 1 1 2 2 1 1 1 1 3 1 1 1 2 1 2 1 1 1 1 1| 47 1.4|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1 1 1 1| 48 1.1|
Medulla, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 27 1.0|
Pelvis, Inflammation | | 1 1.0|
Renal Tubule, Hyperplasia | 1 1 1 2 2 2 2 | 13 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 0| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 7| 3| 3| 2| 3| 8| 7| 3| 5| 3| 3| 3| 0| 2| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3| |
| 1| 1| 0| 1| 3| 0| 5| 0| 0| 2| 1| 1| 1| 3| 5| 2| 2| 0| 0| 1| 0| 3| 6| 0| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
938 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Transitional Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 | 12 1.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation | 1 1 1 1 | 9 1.0|
Transitional Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7|
DAY ON TEST | 5| 3| 8| 3| 3| 3| 3| 3| 4| 3| 3| 1| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 0| 9| 0| 2| 2| 1| 2| 7| 2| 2| 1| 2| 1| 1| 1| 3| 0| 0| 0| 0| 4| 5| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1875 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 1 1 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | |
Degeneration, Cystic | 1 1 1 1 1 1 |
Eosinophilic Focus | X X X X X X X X X X X X X X X X X X|
Hepatodiaphragmatic Nodule | X X |
Inflammation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Mixed Cell Focus | X X X X X X X X X X X|
Necrosis | 1 1 1 |
Vacuolization Cytoplasmic | 2 1 |
Bile Duct, Cholangiofibrosis | |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 1|
Centrilobular, Hypertrophy | 1 1 1 1 1 1 1 1 2 |
Centrilobular, Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 1 1 1 1 1 1 1 1|
Hyperplasia | 1 |
Metaplasia, Hepatocyte | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation | 2 |
Ulcer | 1 1 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7|
DAY ON TEST | 5| 3| 8| 3| 3| 3| 3| 3| 4| 3| 3| 1| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 0| 9| 0| 2| 2| 1| 2| 7| 2| 2| 1| 2| 1| 1| 1| 3| 0| 0| 0| 0| 4| 5| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1875 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 |
Hemorrhage | |
Hyperplasia | 1 1 1 1 1 1 2 |
Hypertrophy | 2 3 1 |
Vacuolization Cytoplasmic | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 1 3 |
Pars Distalis, Hyperplasia | 4 4 2 4 2 3 4 1 2 4 3 4 4|
Pars Nervosa, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 3 1 3 1 1 |
Follicle, Cyst | 1 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Hyperplasia | 1 3 |
Inflammation | 1 1 1 1 1 1 1 |
Duct, Cyst | 3 3 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 1 2 3 1 4 4 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Hyperplasia | 3 3 3 1 3 2 2 2 1 1 2|
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 1 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7|
DAY ON TEST | 5| 3| 8| 3| 3| 3| 3| 3| 4| 3| 3| 1| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 0| 9| 0| 2| 2| 1| 2| 7| 2| 2| 1| 2| 1| 1| 1| 3| 0| 0| 0| 0| 4| 5| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1875 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Inflammation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2|
Hematopoietic Cell Proliferation | 1 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Infarct | 1 |
Pigmentation | 2 2 1 1 2 1 1 2 2 2 1 3 2 2 2 2 2 2 2 2 3 1 2|
Capsule, Fibrosis | |
Lymphoid Follicle, Atrophy | 2 1 |
Red Pulp, Depletion Cellular | 2 |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 4 4 4 4 4 4 3 3 4 3 4 4 3 3 3 3 3 3 3 4 3 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 3 |
Osteoporosis | 4 |
Maxilla, Cyst | 3 |
Maxilla, Inflammation | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 1 1 1 1 1 1 1|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Alveolar Epithelium, Hyperplasia | 3 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 2 |
Degeneration | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7|
DAY ON TEST | 5| 3| 8| 3| 3| 3| 3| 3| 4| 3| 3| 1| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 0| 9| 0| 2| 2| 1| 2| 7| 2| 2| 1| 2| 1| 1| 1| 3| 0| 0| 0| 0| 4| 5| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1875 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Retina, Degeneration | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | 2 2 1 2 2 2 2 2 1 2 2 1 2 3 2 2 2 2 2 1|
Nephropathy | 2 1 1 1 1 1 1 2 1 2 1 1 1 2 2 2 1 1 1 1 2 1 1 2 1|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Medulla, Mineralization | 1 1 1 1 1 1 1|
Renal Tubule, Hyperplasia | 1 2 1 2 1 1 |
Renal Tubule, Hyperplasia, Oncocytic | |
Transitional Epithelium, Hyperplasia | 1 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Inflammation | 1 1 1 1 1 1 1 1 1 1 1|
Transitional Epithelium, Hyperplasia | 3 2 |
Transitional Epithelium, Metaplasia, | |
Squamous | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 0| 3| 2| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 1| 1| 2| 3| 1| 2| 4| 0| 1| 1| 1| 2| 0| 1| 1| 5| 1| 1| 2| 2| 0| 2| 2| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1875 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X X X | 8 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 2 1 1 1 1 1 1 1 1 | 15 1.1|
Basophilic Focus | X X X X X X X X X X X X X X X | 33 |
Clear Cell Focus | X X X X X X | 6 |
Degeneration, Cystic | 2 1 1 1 | 10 1.1|
Eosinophilic Focus | X X X X X X X X X X X X X X X X X X X X X | 39 |
Hepatodiaphragmatic Nodule | X X X X| 6 |
Inflammation | 1 1 1 1 1 1 1 1 2 1 1 1 2 2 1 1 1 1 1 2 1| 38 1.1|
Mixed Cell Focus | X X X X X X X X X X X X | 23 |
Necrosis | 1 1 1 | 6 1.0|
Vacuolization Cytoplasmic | 1 1 | 4 1.3|
Bile Duct, Cholangiofibrosis | 2 | 1 2.0|
Bile Duct, Cyst | 3 | 1 3.0|
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 | 20 1.0|
Centrilobular, Hypertrophy | 1 1 1 1 1 1 1 1 1 1 | 19 1.1|
Centrilobular, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + | 3 |
Fat, Necrosis | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 1 1 1 1 1 1 1 1 2 1| 22 1.0|
Hyperplasia | 1 | 2 1.0|
Metaplasia, Hepatocyte | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 2 1.5|
Inflammation | | 1 2.0|
Ulcer | | 3 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 0| 3| 2| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 1| 1| 2| 3| 1| 2| 4| 0| 1| 1| 1| 2| 0| 1| 1| 5| 1| 1| 2| 2| 0| 2| 2| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1875 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 28 1.0|
Inflammation | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 3 1 1 1 1 1 1 | 9 1.2|
Hemorrhage | 3 | 1 3.0|
Hyperplasia | 1 1 2 1 1 1 4 1 1 1 | 17 1.3|
Hypertrophy | 1 1 1 1 | 7 1.4|
Vacuolization Cytoplasmic | 2 1 1 | 4 1.3|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 | 4 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + M + M + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 2 1 3 4 1 1 | 10 2.2|
Pars Distalis, Hyperplasia | 4 1 1 3 3 4 2 1 1 4 3 1 1 | 26 2.7|
Pars Nervosa, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 1 2 1| 18 1.3|
Follicle, Cyst | | 1 1.0|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 2 | 4 1.8|
Inflammation | 2 2 1 1 | 11 1.2|
Duct, Cyst | 3 | 4 2.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 8 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 0| 3| 2| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 1| 1| 2| 3| 1| 2| 4| 0| 1| 1| 1| 2| 0| 1| 1| 5| 1| 1| 2| 2| 0| 2| 2| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1875 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 2 1 3 1 1 1 1 1 1 | 11 1.3|
Hyperplasia | 3 2 2 1 1 2 3 2| 19 2.1|
__________________________________________________________________________|____________|
Lymph Node | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + M| 48 |
Ectasia | | 1 1.0|
Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 2 2 2 1 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2| 44 1.9|
Hematopoietic Cell Proliferation | 2 2 1 2 2 2 2 2 2 2 2 2 2 2 1 2 1 2 2 2 2 2 2 2 1| 47 1.9|
Infarct | | 1 1.0|
Pigmentation | 2 3 4 3 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 1 2 1 2 1 3| 48 1.9|
Capsule, Fibrosis | 1 | 1 1.0|
Lymphoid Follicle, Atrophy | 4 | 3 2.3|
Red Pulp, Depletion Cellular | 1 | 2 1.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 3 3 4 3 3 3 3 3 4 3 4 3 4 4 4 4 3 4 3 4 3 4 4 4 3| 49 3.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 2 2.0|
Hyperplasia | 3 2 2| 5 2.2|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteopetrosis | | 1 3.0|
Osteoporosis | | 1 4.0|
Maxilla, Cyst | | 1 3.0|
Maxilla, Inflammation | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 0| 3| 2| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 1| 1| 2| 3| 1| 2| 4| 0| 1| 1| 1| 2| 0| 1| 1| 5| 1| 1| 2| 2| 0| 2| 2| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1875 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Inflammation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 1 1 1 1 1 1 1 1 1 1 | 21 1.0|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 47 1.0|
Alveolar Epithelium, Hyperplasia | 1 1 1 | 5 1.4|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 3 |
Cataract | 2 | 2 2.0|
Degeneration | 4 2 | 2 3.0|
Retina, Degeneration | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | 2 2 2 1 2 2 1 2 1 1 3 3 1 1 1 1 1 2 1 1 1 2 1 1| 44 1.7|
Nephropathy | 1 2 3 1 2 1 1 1 1 2 2 1 1 1 1 2 1 2 1 1 1 1 2 1| 49 1.3|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 50 1.0|
Medulla, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 28 1.0|
Renal Tubule, Hyperplasia | 3 4 3 1 3 3 2 1 2| 15 2.0|
Renal Tubule, Hyperplasia, Oncocytic | 2 | 1 2.0|
Transitional Epithelium, Hyperplasia | 1 | 3 1.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calculus Micro Observation Only | X | 1 |
Inflammation | 1 1 1 1 1 1 1 1 1 2 1 1 1 1| 25 1.0|
Transitional Epithelium, Hyperplasia | 4 2 | 4 2.8|
Transitional Epithelium, Metaplasia, | | |
Squamous | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3|
| 0| 9| 1| 2| 2| 0| 0| 0| 0| 2| 2| 0| 0| 9| 1| 2| 1| 0| 0| 1| 6| 1| 0| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
3750 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 1| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + M + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 1 1 1 1 1 1 1 1 |
Basophilic Focus | X X X X X |
Clear Cell Focus | X X X |
Degeneration, Cystic | 1 1 1 1 |
Eosinophilic Focus | X X X X X X X X X X X X X X X X X |
Fibrosis | |
Hepatodiaphragmatic Nodule | X |
Inflammation | 1 1 2 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 2|
Mixed Cell Focus | X X X X X X X X |
Necrosis | 1 1 1 |
Vacuolization Cytoplasmic | 1 1 |
Bile Duct, Cyst | 1 |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 |
Centrilobular, Degeneration | |
Centrilobular, Hypertrophy | 2 1 1 1 1 1 2 2 1 2 1 1 1 1 2 1|
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + M + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 1 1 |
Hyperplasia | 1 |
Hypertrophy, Focal | |
Metaplasia, Hepatocyte | |
Artery, Inflammation | |
Duct, Cyst | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + M + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Stomach, Forestomach | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + M + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Mineralization | 1 |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + M + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3|
| 0| 9| 1| 2| 2| 0| 0| 0| 0| 2| 2| 0| 0| 9| 1| 2| 1| 0| 0| 1| 6| 1| 0| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
3750 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 1| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Inflammation | 2 |
__________________________________________________________________________|
Heart | + M + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation | |
Atrium, Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + M + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 |
Hyperplasia | |
Hypertrophy | 2 2 2 |
Necrosis | |
Vacuolization Cytoplasmic | 1 2 |
__________________________________________________________________________|
Adrenal Medulla | + M + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Hyperplasia | 2 1 4 1 |
__________________________________________________________________________|
Islets, Pancreatic | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + + M + M|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 2 |
Cyst | 2 3 |
Degeneration | 3 |
Pars Distalis, Hyperplasia | 1 4 1 2 3 2 1 1 3 4 3 2 2 4 4 2 4 2 1 1|
Pars Intermedia, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 2 1 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Hyperplasia | 3 |
Inflammation | 1 1 2 1 1 |
Duct, Cyst | |
__________________________________________________________________________|
Ovary | + M + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | 1 3 3 |
__________________________________________________________________________|
Uterus | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1|
Cervix, Hypertrophy | |
Cervix, Inflammation | |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3|
| 0| 9| 1| 2| 2| 0| 0| 0| 0| 2| 2| 0| 0| 9| 1| 2| 1| 0| 0| 1| 6| 1| 0| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
3750 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 1| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cyst, Squamous | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 1 4 1 1 |
Hyperplasia | 2 1 1 3 2 1 2 2 2 2 2 4 3 |
Inflammation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Spleen | + M + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 1 2|
Hematopoietic Cell Proliferation | 2 1 2 2 2 1 2 2 2 2 2 1 1 2 2 2 1 2 3 2 2 2 2|
Pigmentation | 2 3 1 2 2 2 2 1 2 2 2 2 2 2 2 2 3 3 1 2 2 2 2|
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + M + + + + + + + + + + +|
Atrophy | 4 3 3 3 3 3 3 4 4 3 4 4 3 4 4 4 4 3 2 4 3 3 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gliosis | 2 |
Inflammation | |
Mineralization | 1 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + M + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation | 1 2 1 1 1 1 1 1 1 1 1 1 1|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Inflammation | 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3|
| 0| 9| 1| 2| 2| 0| 0| 0| 0| 2| 2| 0| 0| 9| 1| 2| 1| 0| 0| 1| 6| 1| 0| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
3750 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 1| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Cataract | 2 |
Degeneration | 4 3 |
Hemorrhage | 2 |
Retina, Degeneration | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + M + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | 1 1 2 1 1 2 1 1 1 1 1 2 1 1 1 2 2 2 3 1 2|
Hydronephrosis | 2 |
Nephropathy | 1 1 1 3 1 1 1 2 1 1 1 1 1 1 2 2 2 2 2 1 3 2 1 1|
Pigmentation | 1 2 1 1 1 1 1 2 1 1 2 1 1 1 1 1 1 1 1 1 2 1|
Medulla, Mineralization | 1 1 2 1 1 1 1 1 |
Renal Tubule, Hyperplasia | 2 1 1 1 |
Renal Tubule, Hyperplasia, Oncocytic | |
Transitional Epithelium, Hyperplasia | 1 1 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + M + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 2 1 1 1 1 1 1 |
Transitional Epithelium, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 2| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 1| 3| 3| 1| 3| 3| 3| 3| 3| 3| 2| 3| |
| 9| 4| 1| 1| 1| 0| 1| 1| 0| 0| 6| 0| 2| 8| 2| 0| 8| 1| 2| 2| 2| 0| 2| 2| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
3750 PPM | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
| 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 1 1 1 3 1 1 1 1 1 2 1 | 21 1.1|
Basophilic Focus | X X X X X X X X X X | 15 |
Clear Cell Focus | | 3 |
Degeneration, Cystic | 1 1 | 6 1.0|
Eosinophilic Focus | X X X X X X X X X X X X X X X X X| 34 |
Fibrosis | 1 | 1 1.0|
Hepatodiaphragmatic Nodule | X X X X| 5 |
Inflammation | 1 1 1 1 1 2 1 1 1 1 2 2 1 2 2 2 1 1 1 1 1 2 1| 46 1.2|
Mixed Cell Focus | X X X X X | 13 |
Necrosis | | 3 1.0|
Vacuolization Cytoplasmic | 2 3 | 4 1.8|
Bile Duct, Cyst | 3 | 2 2.0|
Bile Duct, Hyperplasia | 1 1 1 1 | 12 1.0|
Centrilobular, Degeneration | 3 | 1 3.0|
Centrilobular, Hypertrophy | 2 1 1 1 2 2 1 1 1 1 | 26 1.3|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Fat, Necrosis | 3 | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 1 1 1 1 1 | 9 1.0|
Hyperplasia | | 1 1.0|
Hypertrophy, Focal | 1 | 1 1.0|
Metaplasia, Hepatocyte | 1 | 1 1.0|
Artery, Inflammation | 3 | 1 3.0|
Duct, Cyst | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + M + + + + + + + + + + + + + +| 48 |
Atrophy | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 | 2 2.0|
Ulcer | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 2| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 1| 3| 3| 1| 3| 3| 3| 3| 3| 3| 2| 3| |
| 9| 4| 1| 1| 1| 0| 1| 1| 0| 0| 6| 0| 2| 8| 2| 0| 8| 1| 2| 2| 2| 0| 2| 2| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
3750 PPM | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
| 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + M + + + + + + + + + + + + + +| 48 |
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 28 1.0|
Inflammation | 1 1 1 | 3 1.0|
Atrium, Thrombosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Cystic | 1 1| 3 1.0|
Hyperplasia | 1 1 1 | 3 1.0|
Hypertrophy | 1 1 | 5 1.6|
Necrosis | 1 | 1 1.0|
Vacuolization Cytoplasmic | 1 | 3 1.3|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 1 4.0|
Hyperplasia | 2 1 | 6 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + M M + M + + + + + + + M M + + +| 41 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 3 2 2 | 6 2.5|
Cyst | 2 | 3 2.3|
Degeneration | | 1 3.0|
Pars Distalis, Hyperplasia | 1 2 2 2 3 3 2 2 2 1 3 2 | 32 2.3|
Pars Intermedia, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 2 1 2 1 1 2 | 18 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 1 1 | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 2| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 1| 3| 3| 1| 3| 3| 3| 3| 3| 3| 2| 3| |
| 9| 4| 1| 1| 1| 0| 1| 1| 0| 0| 6| 0| 2| 8| 2| 0| 8| 1| 2| 2| 2| 0| 2| 2| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
3750 PPM | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
| 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation | 1 1 1 1 1 1 1| 12 1.1|
Duct, Cyst | 1 1 3| 3 1.7|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 3 | 1 3.0|
Cyst | 4 4 3 | 6 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 2 | 4 1.8|
Cervix, Hypertrophy | 4 | 1 4.0|
Cervix, Inflammation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Vagina | + | 1 |
Cyst, Squamous | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 1 3 3 1 1 | 13 1.6|
Hyperplasia | 1 3 1 2 1 3 1 2 1 1 | 23 1.9|
Inflammation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + + + + + + M + + + + + + + + + + + + + +| 47 |
Hyperplasia, Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 4 | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Congestion | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 45 2.0|
Hematopoietic Cell Proliferation | 2 3 2 2 2 1 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2| 46 1.9|
Pigmentation | 2 4 2 2 2 2 2 2 1 1 1 2 4 2 1 1 2 2 2 2 2 2 2 2| 47 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + M + + + + M + + + + + + + + +| 46 |
Atrophy | 3 4 3 3 3 3 4 3 4 3 4 3 4 4 3 3 3 4 3 3 3 4 4| 46 3.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 1 2.0|
Hyperplasia | 3 4 2 | 5 2.6|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 2| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 1| 3| 3| 1| 3| 3| 3| 3| 3| 3| 2| 3| |
| 9| 4| 1| 1| 1| 0| 1| 1| 0| 0| 6| 0| 2| 8| 2| 0| 8| 1| 2| 2| 2| 0| 2| 2| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
3750 PPM | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
| 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
Gliosis | | 1 2.0|
Inflammation | 1| 1 1.0|
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + M + + + + + + + + + + + + + +| 48 |
Foreign Body | X | 1 |
Inflammation | 1 1 1 1 1 1 1 1 1 1 1 | 24 1.0|
Pigmentation | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 48 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 |
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 5 |
Cataract | 2 2 | 3 2.0|
Degeneration | | 2 3.5|
Hemorrhage | | 1 2.0|
Retina, Degeneration | 2 2 | 3 2.3|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Accumulation, Hyaline Droplet | 1 3 2 1 2 3 2 1 3 2 1 1 1 2 1 2 2 3 2 2 1 3 2| 44 1.7|
Hydronephrosis | | 1 2.0|
Nephropathy | 2 2 2 2 2 1 2 1 1 2 1 1 1 1 1 2 1 1 2 1 2 2 2 2 1| 49 1.5|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1| 47 1.1|
Medulla, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1| 20 1.1|
Renal Tubule, Hyperplasia | 3 1 1 2 1 2 1 | 11 1.5|
Renal Tubule, Hyperplasia, Oncocytic | 1 | 1 1.0|
Transitional Epithelium, Hyperplasia | 1 1 1 1 | 10 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation | 1 1 1 1 1 1 1 1 1| 17 1.1|
Transitional Epithelium, Hyperplasia | 1 1| 4 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 4| 5| 6| 7| 6| 7| 6| 6| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 8| 9| 7| 3| 8| 2| 2| 8| 3| 2| 2| 6| 2| 4| 7| 3| 3| 3| 4| 3| 0| 2| 3| 6| 3|
| 5| 3| 4| 0| 1| 9| 0| 8| 0| 4| 9| 5| 9| 0| 7| 0| 0| 0| 5| 0| 8| 9| 0| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 4 |
Inflammation | 1 1 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 |
Basophilic Focus | X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X X |
Congestion | 2 |
Degeneration, Cystic | 1 1 1 1 1 |
Eosinophilic Focus | X X X X |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X X X |
Inflammation | 1 1 1 1 1 1 1 1 1|
Mixed Cell Focus | X X X |
Necrosis | 1 3 1 |
Pigmentation | 1|
Thrombosis | 1 |
Vacuolization Cytoplasmic | 1 3 2 4 2 |
Bile Duct, Cyst | 1 |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 2 1 1 1 2 1 1 1 2 1 1 1 1 1|
Centrilobular, Degeneration | 3 3 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Inflammation | 2 |
Fat, Necrosis | 3 3 3 3 3 |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 2 1 1 2 2 2 1 2 2 1 |
Hyperplasia | 1 4 |
Hypertrophy, Focal | 1 |
Artery, Inflammation | 3 |
Duct, Hyperplasia | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 4| 5| 6| 7| 6| 7| 6| 6| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 8| 9| 7| 3| 8| 2| 2| 8| 3| 2| 2| 6| 2| 4| 7| 3| 3| 3| 4| 3| 0| 2| 3| 6| 3|
| 5| 3| 4| 0| 1| 9| 0| 8| 0| 4| 9| 5| 9| 0| 7| 0| 0| 0| 5| 0| 8| 9| 0| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Foreign Body | X |
Hyperplasia | 1 2 4 |
Inflammation | 2 2 3 |
Ulcer | 2 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Fibrosis | |
Inflammation | |
Mineralization | 2 1 |
Ulcer | 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 1 2 1 1 2 1 2 1 1 2 1 2 1 2 1 2 1 2 |
Mineralization | 3 |
Atrium, Thrombosis | 2 1 1 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 1 1 1 1 |
Hyperplasia | 1 1 1 1 1 |
Hypertrophy | 1 |
Pigmentation | |
Vacuolization Cytoplasmic | 3 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 3 1 1 3 1 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 |
Hyperplasia | 2 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | |
Hemorrhage | 3 |
Pars Distalis, Hyperplasia | 1 1 4 2 2 3 |
Pars Nervosa, Hyperplasia | 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 3 1 |
Follicle, Cyst | 2 |
Follicular Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 4| 5| 6| 7| 6| 7| 6| 6| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 8| 9| 7| 3| 8| 2| 2| 8| 3| 2| 2| 6| 2| 4| 7| 3| 3| 3| 4| 3| 0| 2| 3| 6| 3|
| 5| 3| 4| 0| 1| 9| 0| 8| 0| 4| 9| 5| 9| 0| 7| 0| 0| 0| 5| 0| 8| 9| 0| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation | 2 1 1 2 2 2 1 1 2 3 2 2 1 1 1 2 2 1 1 1 1 2|
Duct, Ectasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation | 2 2 1 1 2 2 1 2 1 3 3 1 3 1 2 1 1 2 2 1|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Mineralization | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 4|
Artery, Inflammation | 2 |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Hyperplasia | 3 3 3 2 1 3 3 4 3 1 1 2 2|
Myelofibrosis | 2 |
Necrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + |
Mediastinal, Hematopoietic Cell | |
Proliferation | |
Mediastinal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 1 2 1 |
Hyperplasia, Plasma Cell | |
Inflammation | |
Necrosis | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Ectasia | 2 |
Hemorrhage | 4 2 |
Necrosis | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
Congestion | 2 2 2 |
Fibrosis | 1 3 |
Hematopoietic Cell Proliferation | 1 1 1 1 2 1 1 1 1 1 2 1 1 1 1 2 1 2 |
Hemorrhage | |
Infarct | |
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 4| 5| 6| 7| 6| 7| 6| 6| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 8| 9| 7| 3| 8| 2| 2| 8| 3| 2| 2| 6| 2| 4| 7| 3| 3| 3| 4| 3| 0| 2| 3| 6| 3|
| 5| 3| 4| 0| 1| 9| 0| 8| 0| 4| 9| 5| 9| 0| 7| 0| 0| 0| 5| 0| 8| 9| 0| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pigmentation | 1 1 2 1 2 2|
Capsule, Fibrosis | |
Lymphoid Follicle, Atrophy | 2 |
Red Pulp, Depletion Cellular | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 4 4 3 4 3 4 4 4 3 4 3 4 3 4 4 4 3 3 3 4 3|
Necrosis | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
Hyperplasia | 1 3 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 1 |
Necrosis | 2 |
Osteopetrosis | 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Cerebrum, Degeneration | 2 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 1 1 1|
Mineralization | 1 |
Pigmentation | 1 |
Thrombosis | 1|
Alveolar Epithelium, Hyperplasia | 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X X X |
Inflammation | 2 2 1 2 |
Respiratory Epithelium, Inflammation | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 2 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 4| 5| 6| 7| 6| 7| 6| 6| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 8| 9| 7| 3| 8| 2| 2| 8| 3| 2| 2| 6| 2| 4| 7| 3| 3| 3| 4| 3| 0| 2| 3| 6| 3|
| 5| 3| 4| 0| 1| 9| 0| 8| 0| 4| 9| 5| 9| 0| 7| 0| 0| 0| 5| 0| 8| 9| 0| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Retina, Degeneration | 3 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | 1 1 |
Cyst | 1 |
Hydronephrosis | |
Infarct | |
Inflammation | 1 1 3 1 |
Mineralization, Diffuse | 1 1 |
Nephropathy | 1 3 1 3 4 3 3 3 3 1 2 2 3 2 2 2 3 2 1 3 4 3 3 1 2|
Pigmentation | 2 1 1 1 1 1 1 1 1 1 1|
Medulla, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Renal Tubule, Hyperplasia | |
Transitional Epithelium, Hyperplasia | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 5| 5| 7| 5| 4| 7| 7| 7| 5| 6| 7| 7| 6| 7| 6| 7| 6| 7| 7| 6| 6| 5| 7| 7| 7| |
DAY ON TEST | 6| 5| 3| 6| 9| 2| 2| 3| 3| 4| 0| 3| 9| 2| 8| 3| 4| 3| 2| 1| 4| 6| 3| 3| 3| |
| 5| 5| 0| 2| 9| 9| 9| 0| 7| 8| 5| 0| 0| 9| 7| 0| 8| 0| 4| 7| 2| 5| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 9| 0| 2| 4| 5| 8| 9| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X| 5 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 4.0|
Inflammation | | 2 1.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 1 | 2 1.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 1 1 1 | 6 1.0|
Basophilic Focus | X X X X X X X X X X X | 25 |
Clear Cell Focus | X X X X | 9 |
Congestion | | 1 2.0|
Degeneration, Cystic | 1 1 1 1 | 9 1.0|
Eosinophilic Focus | X X X X X| 9 |
Hematopoietic Cell Proliferation | 1 1 | 2 1.0|
Hepatodiaphragmatic Nodule | X | 5 |
Inflammation | 1 1 1 1 | 13 1.0|
Mixed Cell Focus | X | 4 |
Necrosis | 1 1 | 5 1.4|
Pigmentation | | 1 1.0|
Thrombosis | | 1 1.0|
Vacuolization Cytoplasmic | | 5 2.4|
Bile Duct, Cyst | | 1 1.0|
Bile Duct, Hyperplasia | 2 1 3 1 2 3 2 1 1 1 2 1 2 2 2 3 1 1 1 2 2 1 1 3 2| 48 1.4|
Centrilobular, Degeneration | | 2 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 10 |
Inflammation | 1 | 2 1.5|
Fat, Necrosis | 3 | 6 3.0|
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 1 1 4 1 2 1 1 1 1 2 2 1 | 26 1.5|
Hyperplasia | | 2 2.5|
Hypertrophy, Focal | | 1 1.0|
Artery, Inflammation | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 5| 5| 7| 5| 4| 7| 7| 7| 5| 6| 7| 7| 6| 7| 6| 7| 6| 7| 7| 6| 6| 5| 7| 7| 7| |
DAY ON TEST | 6| 5| 3| 6| 9| 2| 2| 3| 3| 4| 0| 3| 9| 2| 8| 3| 4| 3| 2| 1| 4| 6| 3| 3| 3| |
| 5| 5| 0| 2| 9| 9| 9| 0| 7| 8| 5| 0| 0| 9| 7| 0| 8| 0| 4| 7| 2| 5| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 9| 0| 2| 4| 5| 8| 9| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Duct, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 4 | 2 3.5|
Foreign Body | | 1 |
Hyperplasia | 1 | 4 2.0|
Inflammation | 3 | 4 2.5|
Ulcer | 3 | 3 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 1 1 | 2 1.0|
Fibrosis | 2 | 1 2.0|
Inflammation | 1 | 1 1.0|
Mineralization | | 2 1.5|
Ulcer | 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 | 3 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 2 2 2 2 1 2 2 1 1 1 1 1 1 1 1 1 1 2 2| 42 1.5|
Mineralization | | 1 3.0|
Atrium, Thrombosis | 4 2 | 6 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 1 1 | 7 1.3|
Hyperplasia | 1 1 1 | 8 1.0|
Hypertrophy | 1 1 3 | 4 1.5|
Pigmentation | 3 | 1 3.0|
Vacuolization Cytoplasmic | 3 | 3 2.3|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 1 1 1 4 1 4 1 | 17 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal | | 1 1.0|
Hyperplasia | 2 1 1 | 5 1.4|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 5| 5| 7| 5| 4| 7| 7| 7| 5| 6| 7| 7| 6| 7| 6| 7| 6| 7| 7| 6| 6| 5| 7| 7| 7| |
DAY ON TEST | 6| 5| 3| 6| 9| 2| 2| 3| 3| 4| 0| 3| 9| 2| 8| 3| 4| 3| 2| 1| 4| 6| 3| 3| 3| |
| 5| 5| 0| 2| 9| 9| 9| 0| 7| 8| 5| 0| 0| 9| 7| 0| 8| 0| 4| 7| 2| 5| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 9| 0| 2| 4| 5| 8| 9| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Cyst | 1 1 | 2 1.0|
Hemorrhage | | 1 3.0|
Pars Distalis, Hyperplasia | 1 1 1 1 3 2 2| 13 1.8|
Pars Nervosa, Hyperplasia | 1 1 1 | 5 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 4 1 1 1 1 | 14 1.4|
Follicle, Cyst | 1 1 | 3 1.3|
Follicular Cell, Hyperplasia | 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 2 | 3 2.7|
Inflammation | 2 2 1 2 2 1 1 1 2 2 1 4 2 1 2 1 1 2 2 2| 42 1.6|
Duct, Ectasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 1 1.0|
Inflammation | 2 3 2 2 1 3 3 2 2 1 3 1 2| 33 1.8|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 2 | 1 2.0|
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 1 | 6 3.5|
Artery, Inflammation | | 1 2.0|
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 27 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 2 2.5|
Hyperplasia | 2 2 2 1 3 3 2 2 3 4 2 3| 25 2.4|
Myelofibrosis | | 1 2.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 8 |
Mediastinal, Hematopoietic Cell | | |
Proliferation | 1 | 1 1.0|
Mediastinal, Pigmentation | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 5| 5| 7| 5| 4| 7| 7| 7| 5| 6| 7| 7| 6| 7| 6| 7| 6| 7| 7| 6| 6| 5| 7| 7| 7| |
DAY ON TEST | 6| 5| 3| 6| 9| 2| 2| 3| 3| 4| 0| 3| 9| 2| 8| 3| 4| 3| 2| 1| 4| 6| 3| 3| 3| |
| 5| 5| 0| 2| 9| 9| 9| 0| 7| 8| 5| 0| 0| 9| 7| 0| 8| 0| 4| 7| 2| 5| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 9| 0| 2| 4| 5| 8| 9| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 1 1 1 2 2 | 8 1.4|
Hyperplasia, Plasma Cell | 2 3 4| 3 3.0|
Inflammation | 1 | 1 1.0|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 2 3.0|
Ectasia | 2 2 | 3 2.0|
Hemorrhage | | 2 3.0|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | X | 1 |
Congestion | 2 2 2 | 6 2.0|
Fibrosis | 3 2 2| 5 2.2|
Hematopoietic Cell Proliferation | 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1 2 1 1 1 | 37 1.2|
Hemorrhage | 2 1 | 2 1.5|
Infarct | 2 | 1 2.0|
Necrosis | | 1 3.0|
Pigmentation | 1 1 1 1 1 1 | 12 1.3|
Capsule, Fibrosis | 2 | 1 2.0|
Lymphoid Follicle, Atrophy | | 1 2.0|
Red Pulp, Depletion Cellular | 1 2 | 3 1.7|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + M M + + + + + + + + M + + +| 46 |
Atrophy | 3 4 3 3 3 3 3 4 4 3 4 3 3 3 4 3 3 3| 40 3.4|
Necrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + M + + + + M + M + + M + + + + +| 45 |
Hyperplasia | 2 1 2 2 1 2| 10 1.8|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | | 2 1.5|
Necrosis | | 1 2.0|
Osteopetrosis | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 5| 5| 7| 5| 4| 7| 7| 7| 5| 6| 7| 7| 6| 7| 6| 7| 6| 7| 7| 6| 6| 5| 7| 7| 7| |
DAY ON TEST | 6| 5| 3| 6| 9| 2| 2| 3| 3| 4| 0| 3| 9| 2| 8| 3| 4| 3| 2| 1| 4| 6| 3| 3| 3| |
| 5| 5| 0| 2| 9| 9| 9| 0| 7| 8| 5| 0| 0| 9| 7| 0| 8| 0| 4| 7| 2| 5| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 9| 0| 2| 4| 5| 8| 9| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 2 1.5|
Cerebrum, Degeneration | | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 1 1 1 1 | 11 1.0|
Mineralization | | 1 1.0|
Pigmentation | 1 1 | 3 1.0|
Thrombosis | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2 | 3 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 4 |
Inflammation | | 4 1.8|
Respiratory Epithelium, Inflammation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Cataract | | 2 2.0|
Retina, Degeneration | | 2 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | 1| 3 1.0|
Cyst | 2 1 | 3 1.3|
Hydronephrosis | 3 2 | 2 2.5|
Infarct | 1 | 1 1.0|
Inflammation | 1 1 1 | 7 1.3|
Mineralization, Diffuse | 1 | 3 1.0|
Nephropathy | 1 2 2 1 1 2 2 3 2 2 2 2 2 2 1 2 2 2 2 2 2 1 3 3 2| 50 2.2|
Pigmentation | 4 3 2 3 1 1 1 3 1 1 2 1 1 1 | 25 1.5|
Medulla, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 30 1.0|
Renal Tubule, Hyperplasia | 1 1 1 | 3 1.0|
Transitional Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 2 1 2 | 28 1.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 4 1 1 1 | 8 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 7| 6| 6| 7| 6| 7| 6|
DAY ON TEST | 6| 0| 2| 6| 3| 2| 7| 2| 3| 2| 3| 1| 2| 8| 2| 6| 9| 2| 3| 7| 6| 0| 7| 1| 4|
| 9| 8| 9| 8| 0| 9| 7| 9| 0| 9| 0| 0| 9| 2| 4| 3| 7| 9| 0| 6| 3| 5| 6| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
469 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Ulcer | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
Ulcer | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 1 1 1 1 1 1 2 1 |
Basophilic Focus | X X X X X X X X X X X X X X X |
Clear Cell Focus | X X |
Degeneration, Cystic | 1 2 1 1 1 1 2 1 1 2 1 1 1 1 1 1|
Eosinophilic Focus | X X X X X X X X X X |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X X X |
Inflammation | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Mixed Cell Focus | X X X |
Necrosis | 1 2 |
Thrombosis | |
Vacuolization Cytoplasmic | 1 2 2 1 2 |
Bile Duct, Hyperplasia | 1 2 2 1 1 2 1 2 1 2 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1|
Centrilobular, Degeneration | 2 |
Centrilobular, Hypertrophy | 1 |
Centrilobular, Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 1 2 1 1 1 1 1 1 4 1 2 |
Hyperplasia | 2 4 |
Hypertrophy, Focal | 1 1 |
Inflammation | 1 |
Artery, Inflammation | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 4 |
Inflammation | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 7| 6| 6| 7| 6| 7| 6|
DAY ON TEST | 6| 0| 2| 6| 3| 2| 7| 2| 3| 2| 3| 1| 2| 8| 2| 6| 9| 2| 3| 7| 6| 0| 7| 1| 4|
| 9| 8| 9| 8| 0| 9| 7| 9| 0| 9| 0| 0| 9| 2| 4| 3| 7| 9| 0| 6| 3| 5| 6| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
469 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Edema | 3 2 3 |
Hyperplasia | 3 2 3 2 2 2 3|
Perforation | |
Ulcer | 4 2 4 4 3 1|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 1 |
Fibrosis | |
Mineralization | 3 3 1 |
Ulcer | 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 3 2 1 1 1 1 1 1 1 1 2 2 1 2 1 2 2 1 2 1 |
Inflammation | 1 |
Mineralization | 1 |
Artery, Inflammation | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 |
Hematopoietic Cell Proliferation | 1 |
Hyperplasia | 2 1 1 1 |
Hypertrophy | |
Vacuolization Cytoplasmic | 2 4 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 2 1 3 1 3 1 1 4 1 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Hyperplasia | 2 2 1 2 3 2 2 1 3 1|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Cyst | 1 |
Pars Distalis, Hyperplasia | 1 4 1 4 4 1 3 1 3 4 1 2 2 |
Pars Intermedia, Hyperplasia | |
Pars Nervosa, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 1 1 3 1 2 1 4 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 2 2|
Follicular Cell, Hypertrophy | 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 7| 6| 6| 7| 6| 7| 6|
DAY ON TEST | 6| 0| 2| 6| 3| 2| 7| 2| 3| 2| 3| 1| 2| 8| 2| 6| 9| 2| 3| 7| 6| 0| 7| 1| 4|
| 9| 8| 9| 8| 0| 9| 7| 9| 0| 9| 0| 0| 9| 2| 4| 3| 7| 9| 0| 6| 3| 5| 6| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
469 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Inflammation | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 1 |
Mineralization | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 |
Inflammation | 1 2 2 2 2 1 2 1 1 2 1 2 2 1|
Duct, Ectasia | 1 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation | 1 3 3 1 1 1 4 3 2 3 3 3 1 3 2 4 3|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 3 4|
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia | 1 1 1 1 2 2 1 3 3 2 3 3 3|
__________________________________________________________________________|
Lymph Node | + + |
Renal, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hyperplasia, Plasma Cell | 3 3 |
Inflammation | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 4 2|
Hemorrhage | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 2 2 2 2 2 1 3 2 2 2 2 1 2 2|
Hematopoietic Cell Proliferation | 2 1 1 1 1 1 1 2 2 1 3 2 1 2 1 1 1 1 1 1|
Infiltration Cellular | |
Pigmentation | 3 1 1 3 2 1 1 2 2 1 2 2 3 2 3 3|
Red Pulp, Depletion Cellular | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + M M + + + + + + + M + M + + M + +|
Atrophy | 4 4 3 4 3 4 3 4 4 4 4 3 4 3 4 4 4 4 4|
Epithelial Cell, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M M + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 7| 6| 6| 7| 6| 7| 6|
DAY ON TEST | 6| 0| 2| 6| 3| 2| 7| 2| 3| 2| 3| 1| 2| 8| 2| 6| 9| 2| 3| 7| 6| 0| 7| 1| 4|
| 9| 8| 9| 8| 0| 9| 7| 9| 0| 9| 0| 0| 9| 2| 4| 3| 7| 9| 0| 6| 3| 5| 6| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
469 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Cyst | |
Hyperplasia | 2 3 1 2 2 3 2 2 2 2 2 4 |
Mineralization | 2 |
Duct, Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hair Follicle, Atrophy | 2|
Subcutaneous Tissue, Inflammation, | |
Granulomatous | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 2 |
Osteomalacia | 2 2 2 2 2 2 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Inflammation | 2 1 2 1 1 1 1|
Mineralization | 3 |
Pigmentation | 1 1 1 1 |
Alveolar Epithelium, Hyperplasia | 1 2 1 1 2 |
Mediastinum, Inflammation | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X |
Hemorrhage | |
Inflammation | 2 4 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | 1 1 1 2 1 1 1 |
Cyst | 1 1 |
Inflammation | 1 1 |
Mineralization, Diffuse | 2 |
Nephropathy | 4 4 3 2 2 2 1 4 3 2 4 4 4 3 3 3 2 4 4 3 4 3 2 4 4|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Medulla, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Renal Tubule, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 7| 6| 6| 7| 6| 7| 6|
DAY ON TEST | 6| 0| 2| 6| 3| 2| 7| 2| 3| 2| 3| 1| 2| 8| 2| 6| 9| 2| 3| 7| 6| 0| 7| 1| 4|
| 9| 8| 9| 8| 0| 9| 7| 9| 0| 9| 0| 0| 9| 2| 4| 3| 7| 9| 0| 6| 3| 5| 6| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
469 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Transitional Epithelium, Hyperplasia | 1 1 2 1 1 2 2 1 1 2 1 1 1 1 1 1 2 1 1 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 1 1 1 |
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 5| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 4| 1| 3| 2| 2| 9| 7| 2| 4| 3| 6| 2| 2| 2| 3| 0| 3| 3| 8| 7| 2| 3| 2| 3| |
| 0| 1| 5| 0| 9| 9| 7| 6| 9| 5| 0| 3| 9| 4| 4| 0| 5| 0| 0| 1| 4| 4| 0| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
469 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 4 | 1 4.0|
Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X X X | 7 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 1 1.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 1 2 1 1 1 1 1 1 1 1| 21 1.1|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X| 35 |
Clear Cell Focus | X X X | 5 |
Degeneration, Cystic | 1 1 1 1 1 2 2 2 2 2 1 1 1 1 1| 31 1.3|
Eosinophilic Focus | X X X X X X X X X X X X | 22 |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hepatodiaphragmatic Nodule | X X X X X| 9 |
Inflammation | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1| 30 1.0|
Mixed Cell Focus | X X X X X X X X X | 12 |
Necrosis | 1 1 1 | 5 1.2|
Thrombosis | 1 | 1 1.0|
Vacuolization Cytoplasmic | 4 1 1 1 1 1 1 1 2 1 1 2 1| 18 1.4|
Bile Duct, Hyperplasia | 2 1 1 1 1 1 1 2 1 1 1 1 2 1 1 2 1 1 1 1 1 1 1 1 2| 50 1.2|
Centrilobular, Degeneration | 1 | 2 1.5|
Centrilobular, Hypertrophy | 1 1 1 | 4 1.0|
Centrilobular, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Fat, Necrosis | 3 | 3 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 1 2 1 2 2 3 1 2 1 1 2 1 1 1 3 | 30 1.5|
Hyperplasia | 1 2 | 4 2.3|
Hypertrophy, Focal | 1 1 1 1 | 6 1.0|
Inflammation | 1 | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 5| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 4| 1| 3| 2| 2| 9| 7| 2| 4| 3| 6| 2| 2| 2| 3| 0| 3| 3| 8| 7| 2| 3| 2| 3| |
| 0| 1| 5| 0| 9| 9| 7| 6| 9| 5| 0| 3| 9| 4| 4| 0| 5| 0| 0| 1| 4| 4| 0| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
469 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Artery, Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 3 2.7|
Inflammation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 | 4 2.8|
Hyperplasia | 3 3 1 3 | 11 2.5|
Perforation | X | 1 |
Ulcer | 4 2 | 8 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 1 2 | 4 1.3|
Fibrosis | 1 | 1 1.0|
Mineralization | 3 | 4 2.5|
Ulcer | | 2 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 4 | 3 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 2 1 1 1 1 3 1 1 1 2 1 1 1 2 2 2 2 1 1 1 1 | 44 1.4|
Inflammation | | 1 1.0|
Mineralization | 1 | 2 1.0|
Artery, Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 1 2 | 4 1.3|
Hematopoietic Cell Proliferation | | 1 1.0|
Hyperplasia | 1 1 1 1 1 1 | 10 1.1|
Hypertrophy | 1 | 1 1.0|
Vacuolization Cytoplasmic | | 2 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 2 1 1 1 2 2 1 1| 24 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 |
Hyperplasia, Focal | 2 | 1 2.0|
Hyperplasia | 3 2 2| 13 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 5| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 4| 1| 3| 2| 2| 9| 7| 2| 4| 3| 6| 2| 2| 2| 3| 0| 3| 3| 8| 7| 2| 3| 2| 3| |
| 0| 1| 5| 0| 9| 9| 7| 6| 9| 5| 0| 3| 9| 4| 4| 0| 5| 0| 0| 1| 4| 4| 0| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
469 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Cyst | 1 1 | 3 1.0|
Pars Distalis, Hyperplasia | 2 1 4 3 2 2 2 1 1 4 4 4 2| 26 2.4|
Pars Intermedia, Hyperplasia | 2 | 1 2.0|
Pars Nervosa, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 22 1.4|
Follicle, Cyst | 1 2| 2 1.5|
Follicular Cell, Hyperplasia | 1 | 3 1.7|
Follicular Cell, Hypertrophy | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
Inflammation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | | 1 1.0|
Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 2 | 4 1.5|
Inflammation | 1 1 2 2 2 1 1 1 1 2 2 2 2 3 1 1 2 1 2 2| 34 1.6|
Duct, Ectasia | 2 2 | 4 2.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 1 2.0|
Inflammation | 4 3 2 4 3 1 3 1 1 3 1 2 3 2 2 3 2 3 3 4| 37 2.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 1 1.0|
Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 4 1 4 4 4| 10 3.6|
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 | 27 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 2 | 2 2.0|
Hyperplasia | 2 4 2 2 2 3 2 3 2 2 2 1 2 2 3| 28 2.1|
__________________________________________________________________________|____________|
Lymph Node | + | 3 |
Renal, Hyperplasia, Plasma Cell | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 5| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 4| 1| 3| 2| 2| 9| 7| 2| 4| 3| 6| 2| 2| 2| 3| 0| 3| 3| 8| 7| 2| 3| 2| 3| |
| 0| 1| 5| 0| 9| 9| 7| 6| 9| 5| 0| 3| 9| 4| 4| 0| 5| 0| 0| 1| 4| 4| 0| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
469 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 1 | 2 1.5|
Hyperplasia, Plasma Cell | | 2 3.0|
Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + + + + + +| 49 |
Ectasia | 2 1 1 | 5 2.0|
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 1 2 2 2 2 1 2 2 2 1 2 2 2 1 2 1 2 2| 35 1.8|
Hematopoietic Cell Proliferation | 2 2 1 1 1 1 1 1 1 4 1 1 2 2 1 1 3 1 1 1 1 2 1 2 2| 45 1.4|
Infiltration Cellular | 4 2 | 2 3.0|
Pigmentation | 1 1 4 2 1 2 1 1 2 1 1 1 1 1 2 2 1 1 1 1| 36 1.7|
Red Pulp, Depletion Cellular | 3 2 | 3 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + M + + + + + + + +| 44 |
Atrophy | 3 3 4 4 4 4 3 3 3 4 3 4 3 3 4 3 3 4 2 4 4 3 4 4| 43 3.6|
Epithelial Cell, Hyperplasia | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 47 |
Cyst | 4 | 1 4.0|
Hyperplasia | 3 2 1 3 1 1 3 3 2| 21 2.2|
Mineralization | | 1 2.0|
Duct, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hair Follicle, Atrophy | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Granulomatous | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 1 | 4 1.8|
Osteomalacia | 2 1 1 2 1 2 | 13 1.7|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 5| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 4| 1| 3| 2| 2| 9| 7| 2| 4| 3| 6| 2| 2| 2| 3| 0| 3| 3| 8| 7| 2| 3| 2| 3| |
| 0| 1| 5| 0| 9| 9| 7| 6| 9| 5| 0| 3| 9| 4| 4| 0| 5| 0| 0| 1| 4| 4| 0| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
469 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation | 1 2 1 1 1 1 | 13 1.2|
Mineralization | 2 | 2 2.5|
Pigmentation | 1 1| 6 1.0|
Alveolar Epithelium, Hyperplasia | 3 1 1 4 | 9 1.8|
Mediastinum, Inflammation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X | 3 |
Hemorrhage | 3 | 1 3.0|
Inflammation | 1 | 3 2.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | 1 1 1 1 2 1 2 | 14 1.2|
Cyst | 2 1| 4 1.3|
Inflammation | 1 1 1 | 5 1.0|
Mineralization, Diffuse | 2 | 2 2.0|
Nephropathy | 4 2 4 3 4 4 1 4 3 2 2 3 2 4 3 3 4 3 3 2 3 4 2 4 4| 50 3.1|
Pigmentation | 1 2 1 1 1 2 1 1 1 1 1 1 1 1 1 | 31 1.1|
Medulla, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 42 1.0|
Renal Tubule, Hyperplasia | 2 1 1 1 2 1 | 7 1.4|
Transitional Epithelium, Hyperplasia | 1 1 1 1 2 1 2 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1| 45 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 1 | 8 1.0|
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 3| 6| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 5| 7|
DAY ON TEST | 1| 9| 6| 3| 0| 2| 2| 2| 2| 4| 3| 3| 3| 2| 2| 0| 0| 2| 3| 2| 6| 2| 8| 9| 2|
| 2| 9| 1| 0| 4| 0| 9| 4| 9| 3| 0| 0| 8| 9| 9| 5| 3| 9| 0| 9| 6| 4| 2| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
938 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 1 1 1 1 1|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X |
Degeneration, Cystic | 1 1 1 1 1 2 1 1 2 1 1 1 2 1 2 1 1 |
Eosinophilic Focus | X X X X X X X X X X X X X X X|
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X |
Inflammation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Mixed Cell Focus | X X X X X X|
Necrosis | 1 1 3 3 |
Vacuolization Cytoplasmic | 1 1 3 1 1 1 1 1 1 1|
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | 1 2 1 1 2 1 1 1 1 1 1 2 2 1 1 1 1 2 1 2 1 1|
Centrilobular, Degeneration | 2 |
Centrilobular, Hypertrophy | 1 1 1 1 1 1 2 1 1 1 1 1|
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Oral Mucosa | + |
Pharyngeal, Hyperplasia | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 2 2 2 1 2 1 2 1 1 1 1|
Hyperplasia | 1|
Hypertrophy, Focal | 1 1 |
Inflammation | |
Artery, Inflammation | 2 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + M + + + + M + + + +|
Hyperplasia | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 4 |
Hyperplasia | 2 2 1 3 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 3| 6| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 5| 7|
DAY ON TEST | 1| 9| 6| 3| 0| 2| 2| 2| 2| 4| 3| 3| 3| 2| 2| 0| 0| 2| 3| 2| 6| 2| 8| 9| 2|
| 2| 9| 1| 0| 4| 0| 9| 4| 9| 3| 0| 0| 8| 9| 9| 5| 3| 9| 0| 9| 6| 4| 2| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
938 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation | |
Perforation | |
Ulcer | 2 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation | |
Mineralization | 2 2 2 1 |
Ulcer | 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 4 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cardiomyopathy | 2 1 1 1 1 1 2 1 1 1 1 1 1 1 1 2 1 1 1 1|
Inflammation | 2 |
Mineralization | 1 |
Atrium, Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Degeneration, Cystic | 1 1 |
Hemorrhage | 2 |
Hyperplasia | 1 1 |
Hypertrophy | |
Thrombosis | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 1 2 2 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + M + + + +|
Hyperplasia | 3 1 3 2 2 1 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 2 |
Hemorrhage | 3 |
Pars Distalis, Hyperplasia | 1 2 1 1 1 2 1 4 1 2 1 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + M + + + + M + + + +|
C-Cell, Hyperplasia | 1 4 1 1 1 1 1 |
Follicle, Cyst | 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 3| 6| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 5| 7|
DAY ON TEST | 1| 9| 6| 3| 0| 2| 2| 2| 2| 4| 3| 3| 3| 2| 2| 0| 0| 2| 3| 2| 6| 2| 8| 9| 2|
| 2| 9| 1| 0| 4| 0| 9| 4| 9| 3| 0| 0| 8| 9| 9| 5| 3| 9| 0| 9| 6| 4| 2| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
938 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Infiltration Cellular | |
Inflammation | 1 1 1 2 1 1 1 1 1 1 1 1 2 1 1 2 2 1 2 1|
Duct, Ectasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 2 2 3 3 3 4 4 1 1 2 2 1 2 2 3 3 3 1 1|
Metaplasia, Squamous | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Mineralization | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 2 1 1 1 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 2 2 2 2 3 3 3 4 2 3 3 3 2 2 3 3 2|
__________________________________________________________________________|
Lymph Node | + |
Mediastinal, Ectasia | 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + M + + + + M + + + +|
Ectasia | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Ectasia | 3 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X |
Angiectasis | 1 |
Congestion | 3 2 2 1 1 1 2 1 2 2 2 2 2 1 2 1 1|
Fibrosis | 3 1 2 |
Hematopoietic Cell Proliferation | 2 4 1 3 1 1 3 2 2 1 2 3 1 2 3 3 1 1 2 1 1|
Pigmentation | 1 1 1 1 2 1 1 1 2 2 1 3 1 1 1 1 2 2 1 1|
Lymphoid Follicle, Atrophy | 4 |
Red Pulp, Depletion Cellular | 2|
__________________________________________________________________________|
Thymus | + + + + M + + + + M + + + + + + M + + + + + + + +|
Atrophy | 4 4 4 4 4 4 4 4 3 4 2 4 4 2 3 3 4 3 4 4 4|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + M + + + + + + + M +|
Hyperplasia | 1 3 3 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 3| 6| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 5| 7|
DAY ON TEST | 1| 9| 6| 3| 0| 2| 2| 2| 2| 4| 3| 3| 3| 2| 2| 0| 0| 2| 3| 2| 6| 2| 8| 9| 2|
| 2| 9| 1| 0| 4| 0| 9| 4| 9| 3| 0| 0| 8| 9| 9| 5| 3| 9| 0| 9| 6| 4| 2| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
938 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Dermis, Fibrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 1 2 |
Osteomalacia | 2 1 2 2 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Hemorrhage | 2 |
Inflammation | 2 1 1 4 |
Mineralization | 1 |
Pigmentation | 1 1 |
Alveolar Epithelium, Hyperplasia | 3 4 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X X |
Inflammation | 2 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 2 |
Inflammation | |
Cornea, Inflammation | 4 |
Retina, Degeneration | 3 3 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | 1 1 1 2 2 1 |
Cyst | 1 1 4 1 |
Hydronephrosis | 2 |
Inflammation | 1 |
Mineralization, Diffuse | 2 2 1 1 1 |
Nephropathy | 1 4 4 2 4 2 2 4 2 3 4 3 4 2 3 4 2 4 2 3 3 2 4 4 3|
Pigmentation | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Medulla, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1|
Renal Tubule, Hyperplasia | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 3| 6| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 5| 7|
DAY ON TEST | 1| 9| 6| 3| 0| 2| 2| 2| 2| 4| 3| 3| 3| 2| 2| 0| 0| 2| 3| 2| 6| 2| 8| 9| 2|
| 2| 9| 1| 0| 4| 0| 9| 4| 9| 3| 0| 0| 8| 9| 9| 5| 3| 9| 0| 9| 6| 4| 2| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
938 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Transitional Epithelium, Hyperplasia | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Inflammation | 1 3 1 1 1 |
Serosa, Inflammation | 4 |
Transitional Epithelium, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| |
DAY ON TEST | 4| 1| 3| 0| 2| 8| 6| 2| 2| 8| 3| 3| 3| 0| 7| 2| 3| 2| 2| 4| 1| 3| 2| 6| 0| |
| 8| 9| 0| 5| 3| 7| 3| 9| 9| 0| 0| 0| 0| 3| 7| 9| 0| 3| 9| 8| 9| 0| 9| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
938 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X X | 7 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 1 1.0|
Ulcer | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 1 1 2 1 2| 13 1.3|
Basophilic Focus | X X X X X X X X X X X X X X X X| 35 |
Clear Cell Focus | X X | 6 |
Degeneration, Cystic | 2 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1 1 1 1| 36 1.2|
Eosinophilic Focus | X X X X X X X X X X X X X X X| 30 |
Hematopoietic Cell Proliferation | 1 1 | 3 1.0|
Hepatodiaphragmatic Nodule | X | 2 |
Inflammation | 1 2 1 1 1 1 1 1 1 1 1 1 1 1| 28 1.0|
Mixed Cell Focus | X X X X X X X X X | 15 |
Necrosis | 1 | 5 1.8|
Vacuolization Cytoplasmic | 1 2 1 1 1 1 1 1 2 1 2 1 1 | 23 1.2|
Bile Duct, Cyst | 2| 1 2.0|
Bile Duct, Hyperplasia | 1 1 1 2 1 2 1 1 2 1 1 1 1 1 1 2 1 1 1 1 1 2 1 1 2| 47 1.3|
Centrilobular, Degeneration | 2 | 2 2.0|
Centrilobular, Hypertrophy | 1 1 1 1 1 1 1 1 1 | 21 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 6 |
Fat, Necrosis | 2 | 2 2.5|
__________________________________________________________________________|____________|
Oral Mucosa | + | 2 |
Pharyngeal, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 1 1 1 1 1 1 1 1 2 1| 25 1.2|
Hyperplasia | 2 | 2 1.5|
Hypertrophy, Focal | 1 | 3 1.0|
Inflammation | 1 1 | 2 1.0|
Artery, Inflammation | 1 | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| |
DAY ON TEST | 4| 1| 3| 0| 2| 8| 6| 2| 2| 8| 3| 3| 3| 0| 7| 2| 3| 2| 2| 4| 1| 3| 2| 6| 0| |
| 8| 9| 0| 5| 3| 7| 3| 9| 9| 0| 0| 0| 0| 3| 7| 9| 0| 3| 9| 8| 9| 0| 9| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
938 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 | 2 3.0|
Hyperplasia | 3 3 3 | 7 2.4|
Inflammation | 4 1 | 2 2.5|
Perforation | X | 1 |
Ulcer | 4 1 | 4 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 3 | 1 3.0|
Inflammation | 1 | 1 1.0|
Mineralization | 2 3 3 | 7 2.1|
Ulcer | 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 4 4 | 4 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Cardiomyopathy | 2 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1 2 3 1 1 2 1 1 1| 44 1.2|
Inflammation | | 1 2.0|
Mineralization | 2 2 1 | 4 1.5|
Atrium, Thrombosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | X | 1 |
Degeneration, Cystic | 1 | 3 1.0|
Hemorrhage | | 1 2.0|
Hyperplasia | 1 1 1 1 1 2| 8 1.1|
Hypertrophy | 1 1 | 2 1.0|
Thrombosis | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 4 1 2 3 1 1 2 1 1 2 1 1 3| 22 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 2 2 4 4 1 2 3 1 3 2 3 2| 19 2.2|
__________________________________________________________________________|____________|
Pituitary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 4 | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| |
DAY ON TEST | 4| 1| 3| 0| 2| 8| 6| 2| 2| 8| 3| 3| 3| 0| 7| 2| 3| 2| 2| 4| 1| 3| 2| 6| 0| |
| 8| 9| 0| 5| 3| 7| 3| 9| 9| 0| 0| 0| 0| 3| 7| 9| 0| 3| 9| 8| 9| 0| 9| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
938 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hemorrhage | | 1 3.0|
Pars Distalis, Hyperplasia | 3 1 4 2 2 3 4 2 3 1 4| 24 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
C-Cell, Hyperplasia | 1 1 1 1 1 3 1 | 14 1.4|
Follicle, Cyst | 2 3 | 3 2.3|
Follicular Cell, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 | 3 1.7|
Infiltration Cellular | 3 | 1 3.0|
Inflammation | 1 1 1 2 2 1 2 1 1 2 4 2 2 2 1 1 2 1 2 2 2 2 3| 43 1.5|
Duct, Ectasia | 4 1 4 4 | 4 3.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 1 3 2 1 1 3 2 3 2 3 1 2 3 2 3| 36 2.2|
Metaplasia, Squamous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 4 | 2 3.5|
Mineralization | 3 | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 1 4 4 4 | 7 3.6|
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 26 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 2 3 3 1 2 1 1 2 3 2 2 2 3 2 2 3| 37 2.4|
__________________________________________________________________________|____________|
Lymph Node | | 1 |
Mediastinal, Ectasia | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Ectasia | 2 | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Ectasia | 3 2 3 2 2 | 7 2.4|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| |
DAY ON TEST | 4| 1| 3| 0| 2| 8| 6| 2| 2| 8| 3| 3| 3| 0| 7| 2| 3| 2| 2| 4| 1| 3| 2| 6| 0| |
| 8| 9| 0| 5| 3| 7| 3| 9| 9| 0| 0| 0| 0| 3| 7| 9| 0| 3| 9| 8| 9| 0| 9| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
938 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Angiectasis | | 1 1.0|
Congestion | 2 2 1 1 1 2 2 2 1 1 2 1 2 2 1 2 2 2 1 2| 37 1.6|
Fibrosis | | 3 2.0|
Hematopoietic Cell Proliferation | 3 1 1 1 1 1 1 1 1 1 1 2 1 1 1 3 1 2 3 2 2 2 1| 44 1.7|
Pigmentation | 1 2 1 3 3 1 1 2 1 1 1 2 1 1 1 2 1 1 | 38 1.4|
Lymphoid Follicle, Atrophy | 2 | 2 3.0|
Red Pulp, Depletion Cellular | 2 | 2 2.0|
__________________________________________________________________________|____________|
Thymus | M + + + + M + + + + + + + + + + + + + + + + + + +| 45 |
Atrophy | 4 4 4 4 3 4 4 4 4 3 4 4 2 2 4 4 3 4 2 2 3 4 3| 44 3.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + + + + M + + + + + + + + + + + + + + + + +| 46 |
Hyperplasia | 1 3 3 2 1 1 2 1 | 12 1.8|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X | 1 |
Dermis, Fibrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 2 2 3 1 | 8 1.9|
Osteomalacia | 2 2 3 1 3 1 3 | 12 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X X | 2 |
Hemorrhage | | 1 2.0|
Inflammation | 1 1 1 4 3 2 1 2 1 | 13 1.8|
Mineralization | 2 1 | 3 1.3|
Pigmentation | 1 1 | 4 1.0|
Alveolar Epithelium, Hyperplasia | 1 1 2 1 3 | 9 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X X X X | 7 |
Inflammation | 2 2 1 2 1 2 | 8 1.9|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| |
DAY ON TEST | 4| 1| 3| 0| 2| 8| 6| 2| 2| 8| 3| 3| 3| 0| 7| 2| 3| 2| 2| 4| 1| 3| 2| 6| 0| |
| 8| 9| 0| 5| 3| 7| 3| 9| 9| 0| 0| 0| 0| 3| 7| 9| 0| 3| 9| 8| 9| 0| 9| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
938 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 4 |
Cataract | 4 | 2 3.0|
Inflammation | 4 | 1 4.0|
Cornea, Inflammation | | 1 4.0|
Retina, Degeneration | 4 | 3 3.3|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | 1 1 1 1 | 10 1.2|
Cyst | 2 2 2 2 4 | 9 2.1|
Hydronephrosis | 2 | 2 2.0|
Inflammation | 1 | 2 1.0|
Mineralization, Diffuse | 1 3 1 3 | 9 1.7|
Nephropathy | 4 4 2 4 4 4 3 2 2 4 2 3 3 2 2 3 4 4 2 4 2 4 3 4 3| 50 3.1|
Pigmentation | 1 1 1 1 1 3 1 1 1 1 1 1 1 1 1 3 1 1 1| 36 1.1|
Medulla, Mineralization | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 46 1.0|
Renal Tubule, Hyperplasia | 2 1 1 | 3 1.3|
Transitional Epithelium, Hyperplasia | 2 2 2 1 1 1 2 2 1 2 2 2 2 2 2 1 1 1 2 1 1 2| 44 1.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4 | 2 4.0|
Inflammation | 1 2 1 1 1 1| 11 1.3|
Serosa, Inflammation | | 1 4.0|
Transitional Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 2| 7| 6| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 6|
DAY ON TEST | 1| 8| 0| 2| 2| 1| 2| 2| 3| 2| 3| 4| 3| 9| 3| 2| 2| 3| 5| 9| 2| 9| 2| 2| 0|
| 7| 3| 5| 7| 9| 9| 8| 9| 0| 8| 7| 9| 0| 0| 0| 9| 9| 0| 3| 0| 9| 3| 9| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1875 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Inflammation | 2 |
Mineralization | 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation | 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 1 1 2 1 |
Basophilic Focus | X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X |
Degeneration, Cystic | 1 1 1 1 1 1 1 2 1 1 1 2 1 1 3 |
Eosinophilic Focus | X X X X X X X X X X X X|
Hematopoietic Cell Proliferation | 1 1 1 |
Hemorrhage | 2 |
Hepatodiaphragmatic Nodule | X X X |
Inflammation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Mineralization | 2 |
Mixed Cell Focus | X X X X X X |
Necrosis | 3 1 1 |
Vacuolization Cytoplasmic | 1 2 1 1 1 1 1 1 |
Bile Duct, Hyperplasia | 1 1 2 2 1 1 1 2 2 2 1 2 1 1 1 1 1 1 1 1 1 1 1 2|
Centrilobular, Degeneration | 3 |
Centrilobular, Hypertrophy | 1 1 2 1 |
Centrilobular, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + + + |
Artery, Inflammation | 3 |
Fat, Inflammation | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 1 1 2 1 1 1 1 1 2 1 1 1 1|
Hyperplasia | 3 2 |
Hypertrophy, Focal | 1 |
Inflammation | |
Artery, Inflammation | |
Artery, Mineralization | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 2| 7| 6| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 6|
DAY ON TEST | 1| 8| 0| 2| 2| 1| 2| 2| 3| 2| 3| 4| 3| 9| 3| 2| 2| 3| 5| 9| 2| 9| 2| 2| 0|
| 7| 3| 5| 7| 9| 9| 8| 9| 0| 8| 7| 9| 0| 0| 0| 9| 9| 0| 3| 0| 9| 3| 9| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1875 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mineralization | 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Hyperplasia | 2 3 |
Mineralization | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 1 |
Inflammation | |
Mineralization | 2 3 3 2 2 |
Ulcer | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 4 4 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 2 1 2 1 1 1 1 1 1 1 1 2 1 1 1 1|
Inflammation | 1 1 |
Mineralization | 1 3 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1 1 1 2 |
Hemorrhage | |
Hyperplasia | 1 1 1 1 1 1 1 1|
Hypertrophy | |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 4 4 1 1 1 1 2 2 3 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Hyperplasia | 3 3 3 3 1 3 2 2 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | 2 1 |
Thrombosis | 2 |
Pars Distalis, Hyperplasia | 1 1 4 2 2 1 1 1 4 2 2 4 1 1 4|
Pars Intermedia, Hyperplasia | 1 |
Pars Nervosa, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 4 2 |
Follicle, Cyst | 1 1 2 |
Follicular Cell, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 2| 7| 6| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 6|
DAY ON TEST | 1| 8| 0| 2| 2| 1| 2| 2| 3| 2| 3| 4| 3| 9| 3| 2| 2| 3| 5| 9| 2| 9| 2| 2| 0|
| 7| 3| 5| 7| 9| 9| 8| 9| 0| 8| 7| 9| 0| 0| 0| 9| 9| 0| 3| 0| 9| 3| 9| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1875 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 2 1 |
Inflammation | 1 |
Mineralization | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 2 2 2 1 2 1 2 2 1 1 1 2 1 1 1 2 1 1 2 2 |
Duct, Ectasia | 1 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hyperplasia | 1 |
Inflammation | 2 2 3 1 1 3 4 2 4 3 3 2 1 3|
Mineralization | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Mineralization | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 |
Thrombosis | 2 |
Artery, Inflammation | |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia | 2 3 2 3 3 3 2 2 1 3 1 2 1 2 4 2 3 1 1 2|
Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Ectasia | |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Atrophy | |
Ectasia | 1 3 4 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 1 3 2 1 2 2 2 2 1 2 2 2 3 2|
Fibrosis | 4 |
Hematopoietic Cell Proliferation | 1 2 1 2 1 1 1 1 2 1 2 2 1 1 1 3 1 3 2 2 1|
Infiltration Cellular | 4 |
Pigmentation | 3 1 1 1 1 1 1 2 1 1 1 2 1 1 1|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 2| 7| 6| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 6|
DAY ON TEST | 1| 8| 0| 2| 2| 1| 2| 2| 3| 2| 3| 4| 3| 9| 3| 2| 2| 3| 5| 9| 2| 9| 2| 2| 0|
| 7| 3| 5| 7| 9| 9| 8| 9| 0| 8| 7| 9| 0| 0| 0| 9| 9| 0| 3| 0| 9| 3| 9| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1875 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoid Follicle, Atrophy | |
Red Pulp, Depletion Cellular | 1 |
__________________________________________________________________________|
Thymus | + + + M + + + + M + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 3 3 3 4 3 4 2 3 4 3 4 3 4 4 3 4 4 3 3 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 3 1 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hemorrhage | 3 |
Hyperplasia | 2 |
Dermis, Fibrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 1 2 1 |
Osteomalacia | 2 3 2 2 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Hemorrhage | 1 |
Inflammation | 1 1 1 1 |
Mineralization | 1 3 2 1 |
Necrosis | 3 |
Pigmentation | 1 1 1 1 |
Thrombosis | 2 |
Alveolar Epithelium, Hyperplasia | 1 4 4 |
Mediastinum, Thrombosis | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X |
Inflammation | 3 2 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + |
Cataract | 3 2 2 2 |
Degeneration | |
Hemorrhage | 2 3 |
Mineralization | 2 2 1 1 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 2| 7| 6| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 6|
DAY ON TEST | 1| 8| 0| 2| 2| 1| 2| 2| 3| 2| 3| 4| 3| 9| 3| 2| 2| 3| 5| 9| 2| 9| 2| 2| 0|
| 7| 3| 5| 7| 9| 9| 8| 9| 0| 8| 7| 9| 0| 0| 0| 9| 9| 0| 3| 0| 9| 3| 9| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1875 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Cornea, Inflammation | 2 |
Retina, Degeneration | 4 3 3 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | 1 1 2 1 1 1 1 1 1 |
Cyst | 1 2 |
Inflammation | 1 1 1 1 |
Mineralization, Diffuse | 1 3 2 3 1 |
Nephropathy | 4 2 2 4 2 2 4 3 4 3 4 1 3 4 3 4 4 3 4 2 2 1 3 3 2|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3 1 1 |
Thrombosis | 1 |
Medulla, Mineralization | 1 1 1 1 1 1 1 1 3 1 1 1 1 1 1 1 1 1 1 3 1 1 1|
Renal Tubule, Hyperplasia | 4 1 1 1 1 |
Renal Tubule, Hyperplasia, Oncocytic | |
Transitional Epithelium, Hyperplasia | 1 1 1 2 1 1 1 1 2 1 1 2 2 2 1 2 1 1 2 2 1 2 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 1 1 1|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 3| 1| 2| 2| 2| 1| 3| 7| 2| 3| 9| 0| 6| 3| 2| 3| 9| 2| 2| 3| 3| 2| 3| 2| |
| 1| 7| 9| 9| 9| 9| 9| 0| 4| 9| 0| 0| 5| 3| 0| 9| 0| 0| 0| 9| 0| 0| 9| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1875 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 | 1 3.0|
Inflammation | | 1 2.0|
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 1.0|
Parasite Metazoan | X X X X X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 1 1 | 9 1.1|
Basophilic Focus | X X X X X X X X X X X X X X X X| 32 |
Clear Cell Focus | X X X X X X | 8 |
Degeneration, Cystic | 3 1 1 1 2 1 1 1 1 1 1 2 1| 28 1.3|
Eosinophilic Focus | X X X X X X X X X X X X X X X X X| 29 |
Hematopoietic Cell Proliferation | | 3 1.0|
Hemorrhage | | 1 2.0|
Hepatodiaphragmatic Nodule | X X | 5 |
Inflammation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 30 1.0|
Mineralization | | 1 2.0|
Mixed Cell Focus | X X X X X X X| 13 |
Necrosis | 1 3 1 2 | 7 1.7|
Vacuolization Cytoplasmic | 1 1 1 2 1 1 1 1 2 | 17 1.2|
Bile Duct, Hyperplasia | 2 1 1 1 2 1 2 1 1 1 1 1 2 2 1 1 1 2 1 1 1 1 2 2 1| 49 1.3|
Centrilobular, Degeneration | | 1 3.0|
Centrilobular, Hypertrophy | 1 1 1 1 1 1 2 1 1 | 13 1.2|
Centrilobular, Necrosis | 3 | 2 2.5|
__________________________________________________________________________|____________|
Mesentery | + + + + | 7 |
Artery, Inflammation | | 1 3.0|
Fat, Inflammation | 2 | 1 2.0|
Fat, Necrosis | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 1 2 1 1 1 3 1 2 2 1 | 28 1.4|
Hyperplasia | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 3| 1| 2| 2| 2| 1| 3| 7| 2| 3| 9| 0| 6| 3| 2| 3| 9| 2| 2| 3| 3| 2| 3| 2| |
| 1| 7| 9| 9| 9| 9| 9| 0| 4| 9| 0| 0| 5| 3| 0| 9| 0| 0| 0| 9| 0| 0| 9| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1875 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hypertrophy, Focal | 1 | 2 1.0|
Inflammation | 1 | 1 1.0|
Artery, Inflammation | 2 | 1 2.0|
Artery, Mineralization | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2| 2 2.5|
Hyperplasia | 3 2| 4 2.5|
Mineralization | 3 | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 2 1.5|
Inflammation | 1 | 1 1.0|
Mineralization | 3 1 3 3 3 | 10 2.5|
Ulcer | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 4 2 3 3 | 7 3.1|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 3 1 1 2 1 1 1 1 2 1 1 1 1 1 1 1 2 2 2 1 1 2 2 2| 43 1.3|
Inflammation | | 2 1.0|
Mineralization | 3 1 3 | 5 2.2|
Atrium, Thrombosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 3 1 | 7 1.6|
Hemorrhage | 2 3 | 2 2.5|
Hyperplasia | 1 1 1 1 1 | 13 1.0|
Hypertrophy | 1 2 1 1 | 4 1.3|
Vacuolization Cytoplasmic | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 1 1 2 1 2 1| 20 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | | 1 2.0|
Hyperplasia | 4 1 2 1 2 3 4 1 1 2 3 | 20 2.3|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 3| 1| 2| 2| 2| 1| 3| 7| 2| 3| 9| 0| 6| 3| 2| 3| 9| 2| 2| 3| 3| 2| 3| 2| |
| 1| 7| 9| 9| 9| 9| 9| 0| 4| 9| 0| 0| 5| 3| 0| 9| 0| 0| 0| 9| 0| 0| 9| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1875 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Angiectasis | | 1 2.0|
Cyst | 4 | 3 2.3|
Thrombosis | | 1 2.0|
Pars Distalis, Hyperplasia | 1 1 3 4 1 1 3 1 1 1 2 1 4 | 28 2.0|
Pars Intermedia, Hyperplasia | 4 | 2 2.5|
Pars Nervosa, Hyperplasia | 1 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 2 1 1 4 1 1 1 1| 13 1.6|
Follicle, Cyst | 2 1 | 5 1.4|
Follicular Cell, Hyperplasia | | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | 1 | 3 1.3|
Inflammation | | 1 1.0|
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
Inflammation | 1 2 1 2 2 2 1 2 2 1 2 2 1 1 2 2 | 37 1.6|
Duct, Ectasia | 3 3 | 4 2.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Hyperplasia | | 1 1.0|
Inflammation | 3 3 2 2 3 2 1 1 3 3 2 4 1 3 2 1 2 | 31 2.3|
Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
Inflammation | 1 | 1 1.0|
Mineralization | 2 | 2 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 4 4 | 6 4.0|
Thrombosis | | 1 2.0|
Artery, Inflammation | 2 | 1 2.0|
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 2 1 1 2 1 1 1 1 1| 24 1.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 3| 1| 2| 2| 2| 1| 3| 7| 2| 3| 9| 0| 6| 3| 2| 3| 9| 2| 2| 3| 3| 2| 3| 2| |
| 1| 7| 9| 9| 9| 9| 9| 0| 4| 9| 0| 0| 5| 3| 0| 9| 0| 0| 0| 9| 0| 0| 9| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1875 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia | 3 2 1 3 2 2 2 3 4 1 2 3 2 1 2 2 | 36 2.2|
Myelofibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 1 2.0|
Ectasia | 2 | 1 2.0|
Hyperplasia, Plasma Cell | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 1.0|
Atrophy | 3 | 1 3.0|
Ectasia | 1 2 2 | 7 2.4|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 1 1 2 2 2 1 2 1 2 2 1 2 2 2 | 30 1.8|
Fibrosis | 1 | 2 2.5|
Hematopoietic Cell Proliferation | 1 1 2 2 1 2 2 2 1 3 1 1 1 2 1 2 3 1 1 2 1 1 | 43 1.5|
Infiltration Cellular | | 1 4.0|
Pigmentation | 1 2 1 1 1 1 1 2 1 1 1 2 1 2 1 1 1 1| 33 1.2|
Lymphoid Follicle, Atrophy | 3 3| 2 3.0|
Red Pulp, Depletion Cellular | 1 2 2| 4 1.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + M + + M + + + + + + + + +| 46 |
Atrophy | 4 4 3 3 3 4 3 3 3 3 3 4 3 4 3 4 4 4 4 3 3 4 4| 46 3.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 1 3 1 1 1 | 12 1.8|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X | 1 |
Hemorrhage | | 1 3.0|
Hyperplasia | | 1 2.0|
Dermis, Fibrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 1 2 2 1 2 2| 11 1.6|
Osteomalacia | 2 2 2 | 8 2.1|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 3| 1| 2| 2| 2| 1| 3| 7| 2| 3| 9| 0| 6| 3| 2| 3| 9| 2| 2| 3| 3| 2| 3| 2| |
| 1| 7| 9| 9| 9| 9| 9| 0| 4| 9| 0| 0| 5| 3| 0| 9| 0| 0| 0| 9| 0| 0| 9| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1875 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 |
Hemorrhage | 3 | 2 2.0|
Inflammation | 1 1 1 2 | 8 1.1|
Mineralization | 3 1 1 | 7 1.7|
Necrosis | | 1 3.0|
Pigmentation | 1| 5 1.0|
Thrombosis | 3 | 2 2.5|
Alveolar Epithelium, Hyperplasia | 2 1 4 3 | 7 2.7|
Mediastinum, Thrombosis | | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X X X| 5 |
Inflammation | 2 1 2| 6 2.2|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 5 |
Cataract | | 4 2.3|
Degeneration | 3 | 1 3.0|
Hemorrhage | | 2 2.5|
Mineralization | | 4 1.5|
Cornea, Inflammation | | 1 2.0|
Retina, Degeneration | | 4 3.3|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | 2 1 1 1 1 1 1 | 16 1.1|
Cyst | 1 2 1 3 3| 7 1.9|
Inflammation | 1 | 5 1.0|
Mineralization, Diffuse | 3 1 2 | 8 2.0|
Nephropathy | 4 2 2 2 3 4 4 3 3 3 2 4 2 2 3 4 2 4 4 4 4 3 3 4 4| 50 3.0|
Pigmentation | 1 1 1 1 1 1 1 2 1 1 2 2 1 1 1 1 1 1 1 1 1| 38 1.1|
Thrombosis | | 1 1.0|
Medulla, Mineralization | 1 1 1 1 1 1 1 1 3 1 2 1 1 2 1 1 1 1 1 1 1 1 1 1| 47 1.2|
Renal Tubule, Hyperplasia | 1 2 1 2| 9 1.6|
Renal Tubule, Hyperplasia, Oncocytic | 2 | 1 2.0|
Transitional Epithelium, Hyperplasia | 2 1 1 1 1 1 1 1 2 2 2 1 1 2 1 2 1 1 1 1 2 2 2 1| 48 1.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 3| 1| 2| 2| 2| 1| 3| 7| 2| 3| 9| 0| 6| 3| 2| 3| 9| 2| 2| 3| 3| 2| 3| 2| |
| 1| 7| 9| 9| 9| 9| 9| 0| 4| 9| 0| 0| 5| 3| 0| 9| 0| 0| 0| 9| 0| 0| 9| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1875 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Inflammation | 1 1 | 8 1.0|
Transitional Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 6| 5| 6| 7| 4| 6| 4| 6| 7| 7| 6| 6| 6| 7| 6| 7| 0| 6| 7| 7|
DAY ON TEST | 2| 3| 0| 2| 3| 0| 3| 8| 2| 2| 8| 8| 9| 2| 2| 4| 7| 8| 3| 3| 2| 6| 9| 3| 3|
| 9| 0| 3| 4| 0| 7| 7| 2| 9| 1| 0| 4| 0| 9| 4| 1| 1| 4| 0| 8| 9| 1| 9| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
3750 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 8| 9| 0| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
Mineralization | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 1 1 |
Basophilic Focus | X X X X X X X X X X|
Clear Cell Focus | X |
Degeneration, Cystic | 1 1 1 2 1 1 1 1 1 2 1 1 1 1|
Eosinophilic Focus | X X X X X X |
Hepatodiaphragmatic Nodule | X X X |
Inflammation | 1 1 1 2 1 1 1 1 1 1 1 1|
Mixed Cell Focus | X X X X |
Necrosis | 2 |
Thrombosis | 1 |
Vacuolization Cytoplasmic | 1 2 1 1 1 2 2 1 1 1 1|
Bile Duct, Hyperplasia | 1 1 1 3 2 1 1 1 1 1 1 1 2 2 1 1 2 1 1 1 1 2 1|
Centrilobular, Degeneration | 2 |
Centrilobular, Hypertrophy | 1 1 1 1 1 1 1 1 1 1 1 1 2 2|
Centrilobular, Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + + + |
Artery, Mineralization | 3 |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 1 2 1 2 1 1 1 1 1 1|
Hyperplasia | |
Hypertrophy, Focal | 1 |
Artery, Hypertrophy | 4 |
Artery, Inflammation | 2 2 |
Artery, Mineralization | 2 2 2 |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + M M + M + + + + +|
Atrophy | 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 6| 5| 6| 7| 4| 6| 4| 6| 7| 7| 6| 6| 6| 7| 6| 7| 0| 6| 7| 7|
DAY ON TEST | 2| 3| 0| 2| 3| 0| 3| 8| 2| 2| 8| 8| 9| 2| 2| 4| 7| 8| 3| 3| 2| 6| 9| 3| 3|
| 9| 0| 3| 4| 0| 7| 7| 2| 9| 1| 0| 4| 0| 9| 4| 1| 1| 4| 0| 8| 9| 1| 9| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
3750 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 8| 9| 0| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Edema | 2 |
Hyperplasia | 2 2 |
Inflammation | |
Mineralization | 1 2 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
Hyperplasia | |
Inflammation | 1 |
Mineralization | 1 2 4 2 2 2 4 3 |
Ulcer | 1 |
__________________________________________________________________________|
Tooth | + |
Inflammation | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 3 1 4 4 |
Aorta, Aneurysm | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 2 1 1 3 1 1 1 3 3 2 1 1 1 2 2 1|
Inflammation | 1 |
Mineralization | 1 1 2 |
Artery, Inflammation | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 4 1 4 2 |
Hyperplasia | 1 1 |
Hypertrophy | |
Necrosis | 2 |
Thrombosis | |
Vacuolization Cytoplasmic | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | 2 2 1 1 1 2 3 1 2 1 |
Thrombosis | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + M M + M + + + + +|
Hyperplasia, Focal | |
Hyperplasia | 3 1 2 3 1 1 1 4 2 |
Inflammation | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 6| 5| 6| 7| 4| 6| 4| 6| 7| 7| 6| 6| 6| 7| 6| 7| 0| 6| 7| 7|
DAY ON TEST | 2| 3| 0| 2| 3| 0| 3| 8| 2| 2| 8| 8| 9| 2| 2| 4| 7| 8| 3| 3| 2| 6| 9| 3| 3|
| 9| 0| 3| 4| 0| 7| 7| 2| 9| 1| 0| 4| 0| 9| 4| 1| 1| 4| 0| 8| 9| 1| 9| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
3750 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 8| 9| 0| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Hyperplasia | 2 1 3 1 3 1 1 2 2 2 3 2 |
Pars Intermedia, Hyperplasia | 2 |
Pars Nervosa, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + M M + M + + + + +|
C-Cell, Hyperplasia | 1 1 2 1|
Follicle, Cyst | 1 3 3 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
Inflammation | 1 |
Mineralization | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hyperplasia | |
Inflammation | 1 2 4 1 2 2 4 1 2 2 1 1 1 4 1 1 1 1 1 2 1 1|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 1 |
Inflammation | 2 3 1 2 1 1 1 2 1 2 3 3 1 1 4 1 3|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 4 |
Mineralization | 2 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Interstitial Cell, Hyperplasia | 1 1 1 1 2 1 1 1 1 1 1 2 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia | 2 3 3 4 2 2 4 4 1 2 3 3 3 4 2 3 |
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M M + M + + + + +|
Atrophy | 3 |
Ectasia | 1 1 |
Hyperplasia, Plasma Cell | 3 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 |
Ectasia | 2 3|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 6| 5| 6| 7| 4| 6| 4| 6| 7| 7| 6| 6| 6| 7| 6| 7| 0| 6| 7| 7|
DAY ON TEST | 2| 3| 0| 2| 3| 0| 3| 8| 2| 2| 8| 8| 9| 2| 2| 4| 7| 8| 3| 3| 2| 6| 9| 3| 3|
| 9| 0| 3| 4| 0| 7| 7| 2| 9| 1| 0| 4| 0| 9| 4| 1| 1| 4| 0| 8| 9| 1| 9| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
3750 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 8| 9| 0| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Accessory Spleen | |
Congestion | 1 2 1 1 1 2 1 1 1 3 2|
Fibrosis | 1 2 |
Hematopoietic Cell Proliferation | 1 2 2 3 2 1 1 1 1 1 1 1 1 2 2 1|
Infiltration Cellular | 1 |
Pigmentation | 1 1 1 2 2 3 3 1 2 1|
Capsule, Hyperplasia | |
Lymphoid Follicle, Atrophy | 3 2 3 2 2 |
Red Pulp, Depletion Cellular | 2 3 |
__________________________________________________________________________|
Thymus | + M + + M M + M M M + + + + + + + + + M M + + + +|
Atrophy | 3 4 4 4 4 2 4 3 4 4 4 3 4 4 4 4 4|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia | 1 1 2 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 1 1 2 2 |
Fracture | X |
Osteomalacia | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Squamous | 2 |
Hemorrhage | 1 3 |
Inflammation | 2 1 1 3 1 1 1|
Mineralization | 1 2 3 2 |
Pigmentation | 1 1 1|
Alveolar Epithelium, Hyperplasia | 1 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X X |
Inflammation | 2 4 2 |
Respiratory Epithelium, Inflammation | 4 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + M + + + + + + +|
Inflammation | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 6| 5| 6| 7| 4| 6| 4| 6| 7| 7| 6| 6| 6| 7| 6| 7| 0| 6| 7| 7|
DAY ON TEST | 2| 3| 0| 2| 3| 0| 3| 8| 2| 2| 8| 8| 9| 2| 2| 4| 7| 8| 3| 3| 2| 6| 9| 3| 3|
| 9| 0| 3| 4| 0| 7| 7| 2| 9| 1| 0| 4| 0| 9| 4| 1| 1| 4| 0| 8| 9| 1| 9| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
3750 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 8| 9| 0| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Inflammation | |
Mineralization | |
Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | 1 1 1 1 1 1|
Cyst | 1 2 1 2 2 1 2 1 |
Hydronephrosis | 4 2 |
Infarct | 2 |
Inflammation | 1 4 |
Mineralization, Diffuse | 2 2 2 1 |
Nephropathy | 2 4 4 2 4 1 4 4 4 4 4 2 4 3 4 4 4 2 3 2 3 2 2 2 3|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 2|
Medulla, Mineralization | 2 1 1 2 1 2 2 2 1 1 2 1 1 2 1 1 1 2 1 2 1 2 1 1|
Renal Tubule, Hyperplasia | 3 4|
Renal Tubule, Hyperplasia, Oncocytic | |
Transitional Epithelium, Hyperplasia | 1 2 1 1 2 1 2 2 2 1 1 1 1 3 1 2 2 1 1 1 4 1 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Inflammation | 1 1 1|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 5| 6| |
DAY ON TEST | 2| 6| 9| 7| 4| 6| 3| 2| 2| 0| 3| 3| 2| 2| 2| 3| 2| 9| 0| 2| 9| 2| 9| 9| 4| |
| 9| 7| 0| 7| 6| 6| 0| 9| 9| 7| 0| 0| 9| 9| 9| 0| 9| 7| 5| 9| 0| 9| 0| 3| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
3750 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| L |
| 0| 1| 2| 3| 4| 5| 8| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 |
Inflammation | 3 | 2 2.0|
Mineralization | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 2 | 1 2.0|
Inflammation | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 1 1 1 1| 9 1.0|
Basophilic Focus | X X X X X X X X X X X X X | 23 |
Clear Cell Focus | X X X X | 5 |
Degeneration, Cystic | 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1| 29 1.1|
Eosinophilic Focus | X X X X X X X X X X X X X X | 20 |
Hepatodiaphragmatic Nodule | X | 4 |
Inflammation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 27 1.0|
Mixed Cell Focus | X X X X X X | 10 |
Necrosis | 1 4 1 1 | 5 1.8|
Thrombosis | | 1 1.0|
Vacuolization Cytoplasmic | 1 2 1 1 1 1 1 1 1 1 1 1 | 23 1.2|
Bile Duct, Hyperplasia | 1 1 2 1 1 1 1 1 2 1 1 1 1 1 2 1 3 1 1 1 1 1 1 1| 47 1.3|
Centrilobular, Degeneration | 2 | 2 2.0|
Centrilobular, Hypertrophy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 29 1.1|
Centrilobular, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 6 |
Artery, Mineralization | 3 | 2 3.0|
Fat, Necrosis | 3 3 | 4 3.0|
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 2 1 1 2 1 1 1 1 1 1 | 24 1.2|
Hyperplasia | 1 | 1 1.0|
Hypertrophy, Focal | 1 | 2 1.0|
Artery, Hypertrophy | | 1 4.0|
Artery, Inflammation | 1 2 3 | 5 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 5| 6| |
DAY ON TEST | 2| 6| 9| 7| 4| 6| 3| 2| 2| 0| 3| 3| 2| 2| 2| 3| 2| 9| 0| 2| 9| 2| 9| 9| 4| |
| 9| 7| 0| 7| 6| 6| 0| 9| 9| 7| 0| 0| 9| 9| 9| 0| 9| 7| 5| 9| 0| 9| 0| 3| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
3750 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| L |
| 0| 1| 2| 3| 4| 5| 8| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Artery, Mineralization | | 3 2.0|
Duct, Cyst | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Atrophy | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 4 | 3 3.0|
Hyperplasia | 2 3 | 4 2.3|
Inflammation | 1 | 1 1.0|
Mineralization | 1 | 4 1.5|
Ulcer | 3 4 4 | 3 3.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 1 1.0|
Hyperplasia | 1 | 1 1.0|
Inflammation | | 1 1.0|
Mineralization | 4 4 | 10 2.8|
Ulcer | 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Inflammation | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 3 4 | 7 3.1|
Aorta, Aneurysm | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 2 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1| 41 1.3|
Inflammation | | 1 1.0|
Mineralization | 2 1 | 5 1.4|
Artery, Inflammation | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 1 1 1 1 | 9 1.9|
Hyperplasia | 1 2 1 1 | 6 1.2|
Hypertrophy | 1 | 1 1.0|
Necrosis | | 1 2.0|
Thrombosis | 1 | 1 1.0|
Vacuolization Cytoplasmic | 3 1 1 | 4 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 5| 6| |
DAY ON TEST | 2| 6| 9| 7| 4| 6| 3| 2| 2| 0| 3| 3| 2| 2| 2| 3| 2| 9| 0| 2| 9| 2| 9| 9| 4| |
| 9| 7| 0| 7| 6| 6| 0| 9| 9| 7| 0| 0| 9| 9| 9| 0| 9| 7| 5| 9| 0| 9| 0| 3| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
3750 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| L |
| 0| 1| 2| 3| 4| 5| 8| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | 1 2 4 1 1 | 15 1.7|
Thrombosis | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 45 |
Hyperplasia, Focal | 4 | 1 4.0|
Hyperplasia | 2 1 4 | 12 2.1|
Inflammation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 4 | 1 4.0|
Cyst | 1 2 | 6 1.2|
Pars Distalis, Hyperplasia | 1 1 2 4 4 2 1 | 19 2.0|
Pars Intermedia, Hyperplasia | | 1 2.0|
Pars Nervosa, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
C-Cell, Hyperplasia | 2 1 1 1 1 1 1 3 | 12 1.3|
Follicle, Cyst | 2 | 4 2.3|
Follicular Cell, Hyperplasia | 1 1 | 3 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | 2 | 1 2.0|
Inflammation | | 1 1.0|
Mineralization | 4 | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Hyperplasia | 2 | 1 2.0|
Inflammation | 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 2 1 1 2 1| 43 1.4|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 1 2.0|
Hyperplasia | | 1 1.0|
Inflammation | 2 4 3 1 1 1 1 2 2 4 1 1 2 1 4 1 2| 34 1.9|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 4.0|
Mineralization | 3 | 3 2.3|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 4 4 4 | 5 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 5| 6| |
DAY ON TEST | 2| 6| 9| 7| 4| 6| 3| 2| 2| 0| 3| 3| 2| 2| 2| 3| 2| 9| 0| 2| 9| 2| 9| 9| 4| |
| 9| 7| 0| 7| 6| 6| 0| 9| 9| 7| 0| 0| 9| 9| 9| 0| 9| 7| 5| 9| 0| 9| 0| 3| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
3750 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| L |
| 0| 1| 2| 3| 4| 5| 8| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Interstitial Cell, Hyperplasia | 1 1 1 2 1 1 1 1 1 1 2 1 1 | 26 1.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 | 1 1.0|
Hyperplasia | 3 3 3 1 1 2 3 2 2 2 1 1 3 2 2 3 3 | 33 2.5|
__________________________________________________________________________|____________|
Lymph Node | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Atrophy | | 1 3.0|
Ectasia | 1 2 | 4 1.3|
Hyperplasia, Plasma Cell | 3 | 3 3.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | | 2 3.0|
Ectasia | 2 2 2 2 2 | 7 2.1|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | X | 1 |
Congestion | 2 1 1 2 1 2 2 2 3 2 1 2 2 2 1 1 2 2 2 2 | 31 1.6|
Fibrosis | | 2 1.5|
Hematopoietic Cell Proliferation | 1 2 2 2 1 1 1 1 2 1 1 1 1 1 1 1 3 1 2 1 2 2 1| 39 1.4|
Infiltration Cellular | | 1 1.0|
Pigmentation | 1 2 2 1 2 1 1 2 1 1 1 2 1 2 1 1 1 1 | 28 1.5|
Capsule, Hyperplasia | 1 | 1 1.0|
Lymphoid Follicle, Atrophy | 3 | 6 2.5|
Red Pulp, Depletion Cellular | | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + M + + + + + + + + + + + + +| 41 |
Atrophy | 4 4 4 3 4 3 2 4 4 4 3 3 3 3 4 4 4 4 3 3 3 4 4 4| 41 3.6|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + M + + + + + + + M + + + + + + +| 47 |
Hyperplasia | 2 4 1 2 2 1 | 10 1.9|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1 1 1 2 | 9 1.4|
Fracture | | 1 |
Osteomalacia | 1 2 | 3 1.7|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 5| 6| |
DAY ON TEST | 2| 6| 9| 7| 4| 6| 3| 2| 2| 0| 3| 3| 2| 2| 2| 3| 2| 9| 0| 2| 9| 2| 9| 9| 4| |
| 9| 7| 0| 7| 6| 6| 0| 9| 9| 7| 0| 0| 9| 9| 9| 0| 9| 7| 5| 9| 0| 9| 0| 3| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
3750 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| L |
| 0| 1| 2| 3| 4| 5| 8| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3| 1 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | +| 2 |
__________________________________________________________________________|____________|
Spinal Cord | +| 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst, Squamous | | 1 2.0|
Hemorrhage | | 2 2.0|
Inflammation | 3 2 1 1 2 1 1 | 14 1.5|
Mineralization | 2 2 | 6 2.0|
Pigmentation | 1 1 | 5 1.0|
Alveolar Epithelium, Hyperplasia | | 3 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X X X | 6 |
Inflammation | 1 2 2 | 6 2.2|
Respiratory Epithelium, Inflammation | 2 | 3 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Inflammation | 3 | 1 3.0|
Mineralization | 3 | 1 3.0|
Retina, Degeneration | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | 1 1 1 2 1 1 1 1 2 1| 16 1.1|
Cyst | 1 1 2 1 2 | 13 1.5|
Hydronephrosis | | 2 3.0|
Infarct | | 1 2.0|
Inflammation | 1 1 | 4 1.8|
Mineralization, Diffuse | 3 2 | 6 2.0|
Nephropathy | 3 4 4 2 4 2 3 3 3 2 3 2 2 3 2 2 3 4 4 3 2 2 2 4 3| 50 3.0|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 33 1.0|
Medulla, Mineralization | 1 1 3 2 1 1 1 1 3 3 3 1 3 2 1 1 2 2 2 2 2 1 2 1 2| 49 1.6|
Renal Tubule, Hyperplasia | 1 1 2 2 1 1 1 | 9 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88036-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ANTHRAQUINONE Date: 02/25/99
Route: DOSED FEED Time: 11:51:10
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 5| 6| |
DAY ON TEST | 2| 6| 9| 7| 4| 6| 3| 2| 2| 0| 3| 3| 2| 2| 2| 3| 2| 9| 0| 2| 9| 2| 9| 9| 4| |
| 9| 7| 0| 7| 6| 6| 0| 9| 9| 7| 0| 0| 9| 9| 9| 0| 9| 7| 5| 9| 0| 9| 0| 3| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
3750 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| L |
| 0| 1| 2| 3| 4| 5| 8| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Hyperplasia, Oncocytic | 1 | 1 1.0|
Transitional Epithelium, Hyperplasia | 2 1 2 2 1 1 1 2 1 1 1 2 2 1 1 2 1 1 2 1 1 1 1 1| 48 1.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
Hemorrhage | | 1 3.0|
Inflammation | 1 1 1 1 1 1 | 9 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------