TDMS Study 88036-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus ANTHRAQUINONE DATE: 02/25/99
EXPERIMENT: 88036 TEST: 03 TIME: 11:51:59
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-25337 ROUTE: DOSED FEED NTP C#: C88036
PATHOLOGIST: SINGER, A. CAS: 84-65-1
------------------------------------------------------------------------------------------------------------------------------------
2 YEAR CHRONIC RATS
REASONS FOR REMOVAL: 25019 Moribund Sacrifice
25020 Natural Death
25021 Terminal Sacrifice
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus ANTHRAQUINONE DATE: 02/25/99
EXPERIMENT: 88036 TEST: 03 TIME: 11:51:59
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-25337 ROUTE: DOSED FEED NTP C#: C88036
PATHOLOGIST: SINGER, A. CAS: 84-65-1
ANTHRAQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 28 CENSORED DEATHS 0 TERMINAL 22 |
| |
| UNCENSORED DEATHS |
| 485 499 537 540 555 562 565 565 593 617 |
| 620 631 642 645 648 648 665 669 674 677 |
| 681 687 688 690 705 708 724 724 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 469 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 27 CENSORED DEATHS 0 TERMINAL 23 |
| |
| UNCENSORED DEATHS |
| 477 481 597 597 615 641 642 645 663 663 |
| 663 668 669 674 676 676 676 682 705 705 |
| 708 710 718 724 724 724 724 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 938 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 28 CENSORED DEATHS 0 TERMINAL 22 |
| |
| UNCENSORED DEATHS |
| 312 477 561 565 596 603 603 620 638 643 |
| 648 648 663 666 680 682 687 699 704 705 |
| 705 705 719 719 723 723 724 724 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ANTHRAQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1875 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 24 CENSORED DEATHS 0 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 249 537 583 593 605 620 628 628 637 653 |
| 663 674 681 690 690 690 690 705 705 717 |
| 719 719 719 727 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 3750 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 28 CENSORED DEATHS 0 TERMINAL 22 |
| |
| UNCENSORED DEATHS |
| 61 421 466 484 537 593 603 607 607 624 |
| 638 641 641 646 667 671 677 680 682 684 |
| 690 690 690 690 697 699 705 724 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ANTHRAQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 100.0 100.0 98.0 92.0 82.0 66.0 44.0 |
| | |
| | |
|469 PPM | 100.0 100.0 100.0 100.0 100.0 96.0 96.0 92.0 78.0 46.0 |
| | |
| | |
|938 PPM | 100.0 100.0 100.0 98.0 98.0 96.0 96.0 86.0 74.0 44.0 |
| | |
| | |
|1875 PPM | 100.0 100.0 98.0 98.0 98.0 98.0 96.0 90.0 78.0 52.0 |
| | |
| | |
|3750 PPM | 98.0 98.0 98.0 98.0 96.0 92.0 90.0 86.0 72.0 44.0 |
| | |
| | |
==================================================================================
ANTHRAQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 44.0% 46.0% 44.0% 52.0% 44.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=1.000 P=0.639N P=0.823N P=0.324N P=1.000N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 630.1 661.0 647.9 646.8 614.8 |
|NATURAL DEATHS (C) | (12.9) (12.3) (16.9) (20.1) (25.0) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 673.6 692.3 683.6 689.5 665.1 |
|(STANDARD ERROR) | (10.0) ( 8.2) (11.0) (11.2) (16.1) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
ANTHRAQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 27 CENSORED DEATHS 0 TERMINAL 23 |
| |
| UNCENSORED DEATHS |
| 550 571 571 575 605 617 617 635 645 645 |
| 649 652 662 665 666 676 676 681 689 702 |
| 703 704 713 715 718 718 718 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 469 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 0 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 513 575 589 592 606 645 647 679 694 718 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 938 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 85 506 570 571 571 625 638 652 655 676 |
| 703 703 718 723 723 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ANTHRAQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1875 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 0 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 550 611 634 635 638 647 675 689 701 704 |
| 722 723 723 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 3750 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 0 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 486 536 689 699 709 712 718 718 722 724 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ANTHRAQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 90.0 72.0 46.0 |
| | |
| | |
|469 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 92.0 86.0 80.0 |
| | |
| | |
|938 PPM | 98.0 98.0 98.0 98.0 98.0 98.0 96.0 90.0 82.0 70.0 |
| | |
| | |
|1875 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 98.0 88.0 74.0 |
| | |
| | |
|3750 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 96.0 96.0 96.0 80.0 |
| | |
| | |
==================================================================================
ANTHRAQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 46.0% 80.0% 70.0% 74.0% 80.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.008N P=0.002N P=0.029N P=0.006N P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 657.0 625.8 607.9 665.5 671.3 |
|NATURAL DEATHS (C) | ( 9.7) (19.7) (41.1) (14.4) (27.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 690.6 709.2 693.4 713.2 718.3 |
|(STANDARD ERROR) | ( 7.4) ( 7.1) (14.4) ( 5.4) ( 6.2) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
ANTHRAQUINONE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
469 PPM = 2
938 PPM = 3
1875 PPM = 4
3750 PPM = 5
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 5 4 3 21
| 5 4 3 5 31 1 4
| 5 5 2 1 1 3 4 2
| 5 5 11 44
92 + 5 51 13 4 242
| 5 11 5 3324 2
P | 5 5 44
E | 3 3 22
R 84 + 1 1 34432 2
C | 1 5 154 4
E | 5 334 4
N | 1 1 224
T 76 + 113 3 44
| 11 32244
S | 5 3 3
U |
R 68 + 1 15533
V | 1122334
I | 112 32
V | 4 4
A 60 + 115 22
L | 11
| 322
| 2 2
52 + 151 3 34
| 11
| 551 1
| 5 22
44 + 11
|
---+---------+---------+---------+---------+---------+---------+---------+---------+---------+---------+---------+---------+--
0 9 18 27 36 45 54 63 72 81 90 99 108
WEEK
NOTE: 29 obs hidden.
ANTHRAQUINONE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
469 PPM = 2
938 PPM = 3
1875 PPM = 4
3750 PPM = 5
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 5 2 1
| 3 5 32 5 1 12 4
| 3 5 11 2 4 4 55
| 1 2 1 44 5 5
P 90 + 3 1 13 42
E | 3 34 4 55
R | 1 1313 2 424 55
C | 3 3 2 2
E 80 + 3 3 24 2
N | 11
T | 1 1 3 33 4
| 11
S 70 + 11 3 3
U |
R | 111
V | 1 1
I 60 +
V |
A | 111
L |
50 +
|
| 1 1
|
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 24 obs hidden.