TDMS Study 88036-04 Pathology Tables
NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39
LAB: Battelle Columbus ANTHRAQUINONE DATE: 12/11/98
EXPERIMENT: 88036 TEST: 04 TIME: 08:50:25
CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP: C88036
CONT: NO1-ES-25337 CAS: 84-65-1
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39
LAB: BATTELLE COLUMBUS LABORATORY ANTHRAQUINONE DATE: 12/11/98
EXPERIMENT: 88036 TEST: 04 TIME: 9:05:56
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP: C88036
CONT: NO1-ES-25337 CAS: 84-65-1
FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE
CHRONIC DOSED FEED STUDY OF ANTHRAQUINONE
==================================================================================================================================
0 PPM 833 PPM 2500 PPM 7500 PPM
---------------- --------------------------------- --------------------------------- ---------------------------------
DOSE/ DOSE/ DOSE/
GRAMS BODY GRAMS BODY CONTROL GRAMS BODY CONTROL GRAMS BODY CONTROL
FEED/ WEIGHT FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/
WEEK DAY(A) (GRAMS) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
==================================================================================================================================
2 4.4 23.0 4.7 23.2 1.07 167 4.8 23.2 1.09 517 4.4 23.4 1.00 1426
6 4.6 28.1 5.1 28.7 1.11 148 5.2 28.6 1.13 456 5.1 28.4 1.11 1334
10 4.8 32.1 4.6 33.3 0.96 116 4.8 33.4 1.00 358 4.7 32.6 0.98 1080
14 4.5 35.5 4.6 37.0 1.02 103 4.8 36.6 1.07 326 4.6 35.8 1.02 954
18 4.5 38.7 4.4 40.5 0.98 90 4.5 40.1 1.00 280 4.5 39.4 1.00 853
22 3.9 41.6 4.1 43.3 1.05 79 4.1 42.6 1.05 239 4.5 41.8 1.15 803
26 4.2 43.3 4.3 44.6 1.02 80 4.2 43.8 1.00 242 4.2 42.9 1.00 743
30 4.1 45.4 4.3 46.1 1.05 77 4.5 45.9 1.10 245 4.4 45.0 1.07 730
34 4.2 46.4 4.2 47.1 1.00 75 4.2 47.2 1.00 225 4.2 46.1 1.00 689
38 4.4 47.3 4.3 47.6 0.98 74 4.4 47.4 1.00 230 4.3 46.8 0.98 693
42 4.3 48.2 4.5 48.5 1.05 77 4.3 48.1 1.00 226 4.5 47.9 1.05 697
46 4.4 48.1 4.4 48.3 1.00 76 4.3 48.2 0.98 225 4.4 47.9 1.00 686
50 4.5 49.4 4.7 50.3 1.04 77 4.5 50.3 1.00 223 4.5 49.6 1.00 686
54 4.4 48.4 4.5 49.5 1.02 76 4.5 50.0 1.02 224 4.5 49.0 1.02 696
58 4.6 49.1 4.6 49.9 1.00 77 4.5 50.5 0.98 222 4.6 49.8 1.00 694
61 4.7 50.1 4.6 50.6 0.98 76 4.6 50.1 0.98 227 4.7 50.5 1.00 699
66 4.1 49.4 4.4 49.9 1.07 73 4.2 50.3 1.02 211 4.3 50.8 1.05 630
70 4.5 49.6 4.6 50.2 1.02 77 4.5 50.5 1.00 224 4.6 49.7 1.02 696
74 4.5 49.4 4.6 50.9 1.02 76 4.5 50.3 1.00 225 4.5 50.4 1.00 675
78 4.6 49.3 4.5 50.7 0.98 74 4.5 50.2 0.98 222 4.5 48.6 0.98 688
82 4.8 49.1 4.8 50.2 1.00 79 4.7 49.6 0.98 234 4.6 46.8 0.96 743
86 4.8 49.0 4.6 50.0 0.96 77 4.7 49.7 0.98 237 4.7 46.2 0.98 768
90 5.0 48.5 4.8 49.8 0.96 81 4.8 49.0 0.96 243 4.7 44.0 0.94 797
94 4.7 48.6 4.5 48.2 0.96 77 4.8 48.3 1.02 246 4.8 41.7 1.02 857
98 4.9 48.4 5.1 48.1 1.04 88 5.0 47.6 1.02 264 5.3 40.0 1.08 992
102 4.6 47.8 4.6 46.3 1.00 83 4.6 46.0 1.00 252 5.0 37.9 1.09 989
1 TO 13 WEEKS
----------------
MEAN 4.6 27.8 4.8 28.4 1.05 144 4.9 28.4 1.07 444 4.7 28.1 1.03 1280
SD(D) 0.2 0.3 0.08 26 0.2 0.07 80 0.3 0.07 179
CV(E) 4.1 5.5 7.4 18.2 5.0 6.2 18.1 6.5 6.8 14.0
14 TO 52 WEEKS
----------------
MEAN 4.3 44.4 4.4 45.3 1.02 81 4.4 45.0 1.02 246 4.4 44.3 1.03 753
SD(D) 0.2 0.2 0.03 9 0.2 0.04 33 0.1 0.05 90
CV(E) 4.9 4.0 2.8 11.0 4.3 3.8 13.4 2.6 5.1 12.0
> 52 WEEKS
----------------
MEAN 4.6 49.0 4.6 49.6 1.00 78 4.6 49.4 1.00 233 4.7 46.6 1.01 763
SD(D) 0.2 0.2 0.03 4 0.2 0.02 15 0.2 0.04 117
CV(E) 4.9 4.0 3.5 5.2 4.2 2.2 6.3 5.3 4.3 15.3
==================================================================================================================================
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE
CHRONIC DOSED FEED STUDY OF ANTHRAQUINONE
==================================================================================================================================
0 PPM 833 PPM 2500 PPM 7500 PPM
---------------- --------------------------------- --------------------------------- ---------------------------------
DOSE/ DOSE/ DOSE/
GRAMS BODY GRAMS BODY CONTROL GRAMS BODY CONTROL GRAMS BODY CONTROL
FEED/ WEIGHT FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/
WEEK DAY(A) (GRAMS) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
==================================================================================================================================
1 3.9 17.0 3.8 17.0 0.97 186 4.2 17.0 1.08 616 4.6 17.4 1.18 2001
2 2.7 18.4 3.0 17.5 1.11 145 3.3 18.6 1.22 443 3.6 18.9 1.33 1445
6 4.7 22.9 4.8 22.3 1.02 179 4.4 23.1 0.94 472 4.7 23.4 1.00 1509
10 5.1 26.5 4.1 26.5 0.80 128 4.2 26.3 0.82 398 4.5 27.7 0.88 1229
14 4.2 29.5 3.7 29.4 0.88 105 4.3 30.2 1.02 357 4.1 30.6 0.98 1002
18 3.8 33.7 3.8 33.6 1.00 95 3.9 34.3 1.03 285 4.1 34.6 1.08 893
22 3.9 36.4 3.8 36.6 0.97 86 3.9 36.5 1.00 266 4.3 36.7 1.10 873
26 3.9 39.0 3.8 38.4 0.97 82 3.9 38.4 1.00 256 4.4 37.7 1.13 866
30 4.6 41.4 4.0 40.8 0.87 82 4.1 41.3 0.89 249 4.0 39.7 0.87 749
34 3.5 43.8 3.5 43.6 1.00 66 3.4 43.4 0.97 198 3.7 42.8 1.06 658
38 3.7 45.4 3.5 45.1 0.95 65 3.5 45.0 0.95 194 3.7 44.0 1.00 631
42 3.7 47.2 3.7 47.0 1.00 65 3.4 46.6 0.92 184 3.6 45.4 0.97 599
46 3.8 48.5 4.3 48.2 1.13 75 3.8 47.7 1.00 199 4.0 47.1 1.05 631
50 3.6 50.8 3.7 50.2 1.03 61 3.6 49.7 1.00 183 3.7 48.4 1.03 581
54 3.5 51.3 3.5 51.4 1.00 56 3.3 50.8 0.94 164 3.5 49.7 1.00 526
58 3.6 52.1 3.7 50.7 1.03 61 3.4 51.1 0.94 168 3.9 49.6 1.08 592
61 3.7 53.3 3.8 53.1 1.03 59 3.8 53.0 1.03 180 3.8 50.8 1.03 566
66 3.3 53.5 3.5 54.0 1.06 55 3.6 54.3 1.09 164 3.4 50.6 1.03 511
70 3.4 54.5 3.6 54.2 1.06 55 3.5 55.1 1.03 160 3.7 52.9 1.09 520
74 3.6 55.9 3.7 55.3 1.03 56 3.7 56.2 1.03 162 3.7 54.4 1.03 516
78 3.4 56.1 3.4 56.0 1.00 51 3.5 56.5 1.03 156 3.5 53.6 1.03 485
82 3.7 56.0 3.8 56.0 1.03 56 3.7 56.9 1.00 162 3.8 54.6 1.03 518
86 3.6 56.1 3.7 55.8 1.03 55 3.5 55.3 0.97 160 3.8 55.3 1.06 514
90 3.5 56.5 4.0 56.8 1.14 59 3.7 55.8 1.06 167 3.7 54.5 1.06 512
94 3.9 55.8 3.8 56.6 0.97 56 4.0 56.5 1.03 178 3.9 54.1 1.00 538
98 4.1 56.8 4.2 56.3 1.02 62 4.3 54.2 1.05 200 4.5 53.2 1.10 628
102 3.6 54.8 3.8 55.2 1.06 58 3.8 53.2 1.06 178 4.0 51.3 1.11 578
1 TO 13 WEEKS
----------------
MEAN 4.1 21.2 3.9 20.8 0.98 159 4.0 21.3 1.01 482 4.4 21.8 1.10 1546
SD(D) 1.0 0.7 0.13 28 0.5 0.17 94 0.5 0.20 326
CV(E) 25.4 18.6 13.2 17.5 12.0 17.0 19.5 11.4 18.1 21.1
14 TO 52 WEEKS
----------------
MEAN 3.9 41.6 3.8 41.3 0.98 78 3.8 41.3 0.98 237 4.0 40.7 1.03 748
SD(D) 0.3 0.2 0.07 14 0.3 0.05 56 0.2 0.08 149
CV(E) 8.0 6.4 7.6 18.3 7.8 4.6 23.8 6.3 7.3 20.0
> 52 WEEKS
----------------
MEAN 3.6 54.8 3.7 54.7 1.03 57 3.7 54.5 1.02 169 3.8 52.7 1.05 539
SD(D) 0.2 0.2 0.04 3 0.3 0.04 12 0.3 0.04 41
CV(E) 6.1 5.9 3.9 5.4 7.2 4.3 7.1 7.0 3.5 7.5
==================================================================================================================================
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
DIAGNOSTIC TRAILER REPORT
FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE
CHRONIC DOSED FEED STUDY OF ANTHRAQUINONE
=========================================================================================================
0 PPM 833 PPM 2500 PPM 7500 PPM
---------------------- ---------------------- ---------------------- ----------------------
DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM
WEEK FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS
==========================================================================================================
B 21.7 50 21.8 50 21.8 50 21.7 50
1 21.7 50 21.8 50 21.8 50 21.7 50
2 4.4 7618 23.0 50 4.7 7688 23.2 50 4.8 7492 23.2 50 4.4 7694 23.4 50
6 4.6 6293 28.1 49 5.1 7650 28.7 50 5.2 7143 28.6 50 5.1 7977 28.4 50
10 4.8 7329 32.1 49 4.6 7741 33.3 50 4.8 7793 33.4 50 4.7 6719 32.6 50
14 4.5 8041 35.5 49 4.6 8184 37.0 50 4.8 8044 36.6 50 4.6 8374 35.8 50
18 4.5 8213 38.7 49 4.4 8166 40.5 50 4.5 8111 40.1 50 4.5 8440 39.4 50
22 3.9 6378 41.6 49 4.1 7169 43.3 50 4.1 7103 42.6 50 4.5 7234 41.8 50
26 4.2 8191 43.3 49 4.3 8374 44.6 50 4.2 8516 43.8 50 4.2 8528 42.9 50
30 4.1 8254 45.4 49 4.3 8415 46.1 50 4.5 8453 45.9 50 4.4 8457 45.0 50
34 4.2 8272 46.4 49 4.2 8584 47.1 50 4.2 8502 47.2 50 4.2 8395 46.1 50
38 4.4 8210 47.3 49 4.3 8278 47.6 50 4.4 8511 47.4 50 4.3 8559 46.8 50
42 4.3 8037 48.2 49 4.5 8341 48.5 50 4.3 8488 48.1 50 4.5 8120 47.9 50
46 4.4 8382 48.1 49 4.4 8480 48.3 50 4.3 8622 48.2 50 4.4 8373 47.9 50
50 4.5 8160 49.4 49 4.7 8437 50.3 50 4.5 8388 50.3 50 4.5 8112 49.6 50
54 4.4 8287 48.4 49 4.5 8342 49.5 50 4.5 8315 50.0 50 4.5 8362 49.0 50
58 4.6 8185 49.1 49 4.6 8390 49.9 50 4.5 8370 50.5 50 4.6 8342 49.8 50
61 4.7 7973 50.1 49 4.6 8436 50.6 50 4.6 8401 50.1 50 4.7 8356 50.5 50
66 4.1 8222 49.4 49 4.4 8232 49.9 50 4.2 8232 50.3 49 4.3 8226 50.8 49
70 4.5 8261 49.6 49 4.6 7903 50.2 48 4.5 8085 50.5 48 4.6 8280 49.7 49
74 4.5 8261 49.4 49 4.6 8105 50.9 48 4.5 7919 50.3 47 4.5 7903 50.4 47
78 4.6 8298 49.3 49 4.5 8122 50.7 48 4.5 7955 50.2 47 4.5 7794 48.6 46
82 4.8 8034 49.1 48 4.8 8100 50.2 48 4.7 7809 49.6 47 4.6 7299 46.8 44
86 4.8 7970 49.0 48 4.6 7928 50.0 48 4.7 7949 49.7 47 4.7 6631 46.2 40
90 5.0 8059 48.5 48 4.8 7691 49.8 47 4.8 7861 49.0 47 4.7 5872 44.0 36
94 4.7 8263 48.6 48 4.5 7777 48.2 47 4.8 8114 48.3 47 4.8 5261 41.7 31
98 4.9 7812 48.4 47 5.1 7222 48.1 42 5.0 7684 47.6 46 5.3 4221 40.0 29
102 4.6 7738 47.8 46 4.6 6953 46.3 42 4.6 7450 46.0 45 5.0 3712 37.9 24
=========================================================================================================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
DIAGNOSTIC TRAILER REPORT
FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE
CHRONIC DOSED FEED STUDY OF ANTHRAQUINONE
=========================================================================================================
0 PPM 833 PPM 2500 PPM 7500 PPM
---------------------- ---------------------- ---------------------- ----------------------
DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM
WEEK FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS
==========================================================================================================
B 17.0 50 17.0 50 17.0 50 17.4 50
1 3.9 3113 17.0 50 3.8 3447 17.0 50 4.2 3446 17.0 50 4.6 3444 17.4 50
2 2.7 3794 18.4 50 3.0 4755 17.5 50 3.3 4278 18.6 50 3.6 4763 18.9 50
5 4.1 3776 4.4 3680 4.1 3678 4.2 3680
6 4.7 4232 22.9 50 4.8 3724 22.3 50 4.4 3244 23.1 50 4.7 4629 23.4 50
9 4.4 3600 3.9 3600 4.3 3600 4.3 3600
10 5.1 4795 26.5 50 4.1 4314 26.5 50 4.2 3837 26.3 50 4.5 4799 27.7 50
13 4.4 3583 4.5 3565 4.7 3560 4.7 3555
14 4.2 4829 29.5 50 3.7 4861 29.4 50 4.3 4876 30.2 50 4.1 4926 30.6 50
17 4.0 3615 3.7 3610 4.1 3610 4.0 3615
18 3.8 4826 33.7 50 3.8 4844 33.6 50 3.9 4873 34.3 50 4.1 4858 34.6 50
21 3.6 3656 3.7 3632 3.7 3622 4.4 3630
22 3.9 4830 36.4 50 3.8 4791 36.6 50 3.9 4787 36.5 50 4.3 4836 36.7 50
25 4.0 3605 3.8 3610 3.9 3604 4.0 3602
26 3.9 4807 39.0 50 3.8 4868 38.4 50 3.9 4938 38.4 50 4.4 4920 37.7 49
29 4.2 3715 3.5 3238 3.8 3675 4.0 3451
30 4.6 4712 41.4 50 4.0 4889 40.8 50 4.1 4854 41.3 50 4.0 4285 39.7 48
33 3.6 3630 3.7 3550 3.8 3555 3.9 3496
34 3.5 4831 43.8 50 3.5 4799 43.6 50 3.4 4813 43.4 50 3.7 4669 42.8 48
37 3.7 3607 3.7 3636 3.6 3654 3.6 3524
38 3.7 4703 45.4 49 3.5 4800 45.1 50 3.5 4794 45.0 50 3.7 4608 44.0 48
41 3.4 3537 3.6 3635 3.6 3488 3.7 3448
42 3.7 4606 47.2 49 3.7 4679 47.0 50 3.4 4840 46.6 50 3.6 4557 45.4 48
45 4.0 3413 3.8 3478 3.9 3463 3.8 3031
46 3.8 4770 48.5 49 4.3 4875 48.2 50 3.8 4868 47.7 50 4.0 4662 47.1 48
49 3.6 3534 3.8 3605 3.9 3605 3.9 3461
50 3.6 4698 50.8 49 3.7 4817 50.2 50 3.6 4854 49.7 50 3.7 4736 48.4 48
53 3.3 3584 3.3 3650 3.3 3590 3.5 3446
54 3.5 4607 51.3 49 3.5 4717 51.4 50 3.3 4734 50.8 50 3.5 4558 49.7 48
57 3.3 3602 3.5 3685 3.6 3698 3.4 3566
58 3.6 4661 52.1 49 3.7 4715 50.7 50 3.4 4721 51.1 50 3.9 4532 49.6 48
61 3.7 8175 53.3 49 3.8 8422 53.1 50 3.8 8331 53.0 50 3.8 8052 50.8 48
65 3.2 3552 3.4 3647 3.5 3670 3.1 3464
66 3.3 4748 53.5 49 3.5 4791 54.0 50 3.6 4789 54.3 50 3.4 4643 50.6 48
69 3.7 3476 3.8 3545 3.8 3550 3.5 2980
70 3.4 4832 54.5 49 3.6 4908 54.2 50 3.5 4905 55.1 50 3.7 4608 52.9 47
73 3.6 3513 3.8 3512 3.7 3427 3.8 3342
74 3.6 4758 55.9 49 3.7 4755 55.3 49 3.7 4660 56.2 48 3.7 4562 54.4 47
77 3.5 3419 3.6 3428 3.7 3428 3.6 3363
78 3.4 4689 56.1 48 3.4 4671 56.0 48 3.5 4674 56.5 48 3.5 4582 53.6 47
81 3.6 3317 3.9 3384 3.8 3443 3.7 3312
82 3.7 4447 56.0 46 3.8 4546 56.0 47 3.7 4638 56.9 47 3.8 4423 54.6 46
85 3.8 3200 3.9 3259 3.8 3278 4.0 3263
86 3.6 4381 56.1 45 3.7 4518 55.8 46 3.5 4491 55.3 46 3.8 4520 55.3 46
89 3.6 3157 4.1 3251 4.0 3304 3.6 3391
90 3.5 4077 56.5 43 4.0 4333 56.8 45 3.7 4292 55.8 44 3.7 4408 54.5 46
93 3.8 2970 3.7 3187 4.2 2912 4.0 3201
94 3.9 4081 55.8 42 3.8 4284 56.6 44 4.0 3961 56.5 41 3.9 4351 54.1 45
97 4.5 2960 4.3 3194 3.9 2623 4.3 3282
98 4.1 3904 56.8 41 4.2 4196 56.3 44 4.3 3602 54.2 38 4.5 4252 53.2 44
=========================================================================================================
DIAGNOSTIC TRAILER REPORT
FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE
CHRONIC DOSED FEED STUDY OF ANTHRAQUINONE
=========================================================================================================
0 PPM 833 PPM 2500 PPM 7500 PPM
---------------------- ---------------------- ---------------------- ----------------------
DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM
WEEK FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS
==========================================================================================================
101 3.6 2730 3.9 2994 4.1 2527 4.4 3020
102 3.6 3798 54.8 39 3.8 4117 55.2 42 3.8 3511 53.2 36 4.0 4167 51.3 43
MEAN BODY WGT FOR WEEKS
1 TO 13 21.2 20.8 21.3 21.8
14 TO 52 41.6 41.3 41.3 40.7
> 52 54.8 54.7 54.5 52.7
=========================================================================================================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.