TDMS Study 88036-04 Pathology Tables
NTP Experiment-Test: 88036-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ANTHRAQUINONE Date: 12/11/98
Route: DOSED FEED Time: 08:59:08
2 YEAR CHRONIC MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 84-65-1
Lock Date: 07/01/97
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 88036-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ANTHRAQUINONE Date: 12/11/98
Route: DOSED FEED Time: 08:59:08
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 833 PPM 2500 PPM 7500 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Natural Death 9 5 8 5
Moribund Sacrifice 6 3 4 2
Accidently Killed 3
Survivors
Terminal Sacrifice 35 42 35 42
Missing 1
Animals Examined Microscopically 50 50 50 49
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ALIMENTARY SYSTEM
Intestine Small, Jejunum (50) (50) (50) (49)
Liver (49) (50) (50) (49)
Hemangiosarcoma 1 (2%)
Hepatoblastoma 1 (2%)
Hepatocellular Carcinoma 2 (4%) 1 (2%) 7 (14%) 6 (12%)
Hepatocellular Carcinoma, Multiple 2 (4%) 1 (2%) 2 (4%)
Hepatocellular Adenoma 5 (10%) 11 (22%) 14 (28%) 10 (20%)
Hepatocellular Adenoma, Multiple 1 (2%) 17 (34%) 13 (26%) 30 (61%)
Histiocytic Sarcoma 2 (4%) 1 (2%) 2 (4%)
Ito Cell Tumor Malignant 1 (2%)
Mesentery (6) (4) (6) (7)
Histiocytic Sarcoma 1 (17%)
Pancreas (50) (50) (50) (49)
Salivary Glands (49) (49) (50) (49)
Stomach, Forestomach (50) (50) (50) (49)
Squamous Cell Papilloma 3 (6%) 1 (2%)
Stomach, Glandular (50) (50) (50) (49)
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CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (49)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Histiocytic Sarcoma 1 (2%)
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NTP Experiment-Test: 88036-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ANTHRAQUINONE Date: 12/11/98
Route: DOSED FEED Time: 08:59:08
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 833 PPM 2500 PPM 7500 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (49)
Hemangiosarcoma 1 (2%)
Adrenal Medulla (50) (50) (49) (49)
Pheochromocytoma Malignant 1 (2%)
Pituitary Gland (47) (50) (48) (46)
Histiocytic Sarcoma 1 (2%)
Pars Distalis, Adenoma 4 (9%) 7 (14%) 4 (8%) 6 (13%)
Thyroid Gland (45) (48) (48) (48)
Follicular Cell, Adenoma 1 (2%) 1 (2%) 2 (4%) 2 (4%)
Follicular Cell, Carcinoma 2 (4%)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (45) (50) (49) (49)
Cystadenoma 2 (4%) 2 (4%)
Hemangiosarcoma 1 (2%)
Uterus (50) (50) (50) (49)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma 2 (4%)
Leiomyoma 1 (2%)
Polyp Stromal 1 (2%)
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HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (49)
Histiocytic Sarcoma 1 (2%)
Lymph Node (5) (2) (4) (4)
Lumbar, Histiocytic Sarcoma 1 (20%)
Mediastinal, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (25%)
Lymph Node, Mandibular (48) (46) (48) (49)
Histiocytic Sarcoma 1 (2%)
Lymph Node, Mesenteric (48) (50) (49) (48)
Histiocytic Sarcoma 1 (2%)
Spleen (45) (49) (48) (48)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma 2 (4%)
Thymus (44) (47) (46) (44)
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 88036-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ANTHRAQUINONE Date: 12/11/98
Route: DOSED FEED Time: 08:59:08
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 833 PPM 2500 PPM 7500 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (48) (48) (49)
Carcinoma 1 (2%)
Skin (50) (50) (50) (49)
Squamous Cell Carcinoma 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 2 (4%) 2 (4%) 1 (2%)
Subcutaneous Tissue, Hemangioma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%) 1 (2%)
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MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (49)
Osteosarcoma 1 (2%)
Skeletal Muscle (3) (2) (2) (1)
Fibrosarcoma, Metastatic, Skin 1 (33%) 1 (50%) 1 (50%)
Rhabdomyosarcoma 1 (100%)
Sarcoma, Metastatic, Skin 1 (50%) 1 (50%)
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NERVOUS SYSTEM
Brain (50) (50) (50) (49)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Spinal Cord (2) (1)
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RESPIRATORY SYSTEM
Lung (50) (50) (50) (49)
Alveolar/Bronchiolar Adenoma 1 (2%) 1 (2%) 2 (4%) 3 (6%)
Alveolar/Bronchiolar Carcinoma 3 (6%) 3 (6%)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Hemangiosarcoma 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 2 (4%)
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SPECIAL SENSES SYSTEM
Harderian Gland (2) (4) (4) (1)
Adenoma 2 (100%) 3 (75%) 4 (100%) 1 (100%)
Carcinoma 1 (25%)
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NTP Experiment-Test: 88036-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ANTHRAQUINONE Date: 12/11/98
Route: DOSED FEED Time: 08:59:08
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 833 PPM 2500 PPM 7500 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (49) (49)
Histiocytic Sarcoma 2 (4%)
Urinary Bladder (44) (48) (46) (48)
Hemangioma 1 (2%)
Histiocytic Sarcoma 1 (2%)
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SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(49)
Histiocytic Sarcoma 2 (4%) 1 (2%) 2 (4%) 1 (2%)
Lymphoma Malignant 14 (28%) 8 (16%) 8 (16%) 10 (20%)
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* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 88036-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ANTHRAQUINONE Date: 12/11/98
Route: DOSED FEED Time: 08:59:08
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 833 PPM 2500 PPM 7500 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 28 38 41 44
Total Primary Neoplasms 45 63 63 82
Total Animals with Benign Neoplasms 13 31 32 40
Total Benign Neoplasms 19 41 43 54
Total Animals with Malignant Neoplasms 21 17 18 25
Total Malignant Neoplasms 26 22 20 28
Total Animals with Metastatic Neoplasms 1 4 3 1
Total Metastatic Neoplasm 1 4 3 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
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a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
NTP Experiment-Test: 88036-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ANTHRAQUINONE Date: 12/11/98
Route: DOSED FEED Time: 08:59:08
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 833 PPM 2500 PPM 7500 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Natural Death 2 6 4 19
Moribund Sacrifice 3 3 3 8
Survivors
Terminal Sacrifice 45 41 43 23
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Jejunum (50) (50) (50) (50)
Carcinoma 1 (2%)
Liver (50) (50) (50) (49)
Hemangiosarcoma 1 (2%) 1 (2%)
Hepatoblastoma 1 (2%) 5 (10%) 11 (22%) 21 (43%)
Hepatoblastoma, Multiple 1 (2%) 16 (33%)
Hepatocellular Carcinoma 7 (14%) 9 (18%) 12 (24%) 12 (24%)
Hepatocellular Carcinoma, Multiple 1 (2%) 4 (8%) 5 (10%) 9 (18%)
Hepatocellular Adenoma 16 (32%) 10 (20%) 10 (20%) 10 (20%)
Hepatocellular Adenoma, Multiple 5 (10%) 22 (44%) 28 (56%) 31 (63%)
Hepatocholangiocarcinoma 1 (2%)
Histiocytic Sarcoma 1 (2%) 2 (4%) 1 (2%)
Mesentery (2) (2) (1) (5)
Oral Mucosa (1)
Squamous Cell Carcinoma 1 (100%)
Pancreas (50) (50) (50) (50)
Salivary Glands (50) (50) (50) (50)
Hemangiosarcoma 1 (2%)
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CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
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ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Capsule, Adenoma 1 (2%)
Adrenal Medulla (49) (50) (50) (49)
Pheochromocytoma Benign 1 (2%) 1 (2%) 1 (2%)
Islets, Pancreatic (50) (50) (50) (42)
NTP Experiment-Test: 88036-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ANTHRAQUINONE Date: 12/11/98
Route: DOSED FEED Time: 08:59:08
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 833 PPM 2500 PPM 7500 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Adenoma 1 (2%) 1 (2%)
Carcinoma 1 (2%)
Pituitary Gland (48) (48) (47) (46)
Pars Distalis, Adenoma 1 (2%)
Thyroid Gland (50) (50) (49) (46)
C-Cell, Carcinoma 1 (2%)
Follicular Cell, Adenoma 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Hemangiosarcoma 1 (2%)
Prostate (50) (50) (50) (50)
Testes (50) (49) (50) (50)
Interstitial Cell, Adenoma 1 (2%) 1 (2%)
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HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hemangiosarcoma 1 (2%)
Lymph Node (1) (1) (3)
Mediastinal, Histiocytic Sarcoma 1 (33%)
Lymph Node, Mandibular (48) (45) (44) (48)
Lymph Node, Mesenteric (49) (49) (47) (40)
Histiocytic Sarcoma 1 (2%)
Spleen (50) (50) (49) (42)
Hemangiosarcoma 2 (4%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Thymus (45) (48) (40) (42)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (49)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 2 (4%)
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 88036-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ANTHRAQUINONE Date: 12/11/98
Route: DOSED FEED Time: 08:59:08
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 833 PPM 2500 PPM 7500 PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1)
Schwannoma Malignant, Metastatic, Skin 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 10 (20%) 7 (14%) 6 (12%) 8 (16%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 8 (16%) 11 (22%) 8 (16%) 3 (6%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%) 3 (6%) 1 (2%)
Hepatoblastoma, Metastatic, Liver 1 (2%) 8 (16%)
Hepatocellular Carcinoma, Metastatic, Liver 4 (8%) 1 (2%) 2 (4%) 5 (10%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (3) (4) (4) (4)
Adenoma 3 (100%) 4 (100%) 4 (100%) 4 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (47)
Histiocytic Sarcoma 1 (2%)
Renal Tubule, Adenoma 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%) 2 (4%) 1 (2%)
Lymphoma Malignant 3 (6%) 3 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 88036-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ANTHRAQUINONE Date: 12/11/98
Route: DOSED FEED Time: 08:59:08
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 833 PPM 2500 PPM 7500 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 35 38 47 48
Total Primary Neoplasms 62 82 102 126
Total Animals with Benign Neoplasms 27 34 41 43
Total Benign Neoplasms 37 46 56 57
Total Animals with Malignant Neoplasms 18 28 33 45
Total Malignant Neoplasms 25 36 46 69
Total Animals with Metastatic Neoplasms 4 2 4 12
Total Metastatic Neoplasm 4 4 4 13
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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