TDMS Study 88045-03 Pathology Tables
NTP Experiment-Test: 88045-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY BUTANAL OXIME Date: 09/30/98
Route: GAVAGE Time: 09:43:20
13 WEEK SUBCHRONIC
Facility: Battelle Columbus Laboratory
Chemical CAS #: 110-69-0
Lock Date: 11/13/96
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 88045-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY BUTANAL OXIME Date: 09/30/98
Route: GAVAGE Time: 09:43:20
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 25 MG/KG 50 MG/KG 100 200 600
MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Natural Death 9
Moribund Sacrifice 1
Survivors
Terminal Sacrifice 10 10 10 10 10
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10) (10) (10)
Hepatodiaphragmatic Nodule 3 (30%) 1 (10%) 2 (20%) 2 (20%) 1 (10%) 1 (10%)
Inflammation, Chronic Active 8 (80%) 8 (80%) 6 (60%) 5 (50%) 4 (40%)
Necrosis 10 (100%)
Stomach, Glandular (10) (10) (10)
Congestion 1 (10%)
Erosion 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (10) (10)
Inflammation, Chronic Active 3 (30%) 4 (40%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (1) (10) (10)
Inflammation, Chronic Active 1 (10%)
Thyroid Gland (10) (10) (10)
Infiltration Cellular, Lymphocyte 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88045-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY BUTANAL OXIME Date: 09/30/98
Route: GAVAGE Time: 09:43:20
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 25 MG/KG 50 MG/KG 100 200 600
MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (10) (10) (10) (10) (10) (10)
Hyperplasia 3 (30%) 10 (100%)
Lymph Node, Mandibular (10) (10) (10)
Atrophy 8 (80%)
Hyperplasia, Histiocytic 2 (20%) 2 (20%)
Hyperplasia, Plasma Cell 1 (10%)
Lymph Node, Mesenteric (10) (4) (1) (5) (10) (10)
Atrophy 7 (70%)
Hyperplasia, Histiocytic 4 (40%) 4 (100%) 1 (100%) 5 (100%) 4 (40%)
Spleen (10) (10) (10) (10) (10) (10)
Hematopoietic Cell Proliferation 7 (70%) 9 (90%) 8 (80%) 10 (100%) 10 (100%) 9 (90%)
Pigmentation 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Lymphatic, Depletion Cellular 9 (90%)
Thymus (10) (10) (10) (10) (10) (10)
Atrophy 1 (10%) 1 (10%)
Hemorrhage 1 (10%)
Necrosis 10 (100%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10)
Inflammation, Chronic Active 1 (10%)
Nose (10) (10) (10) (10) (10) (10)
Inflammation, Chronic Active 2 (20%) 1 (10%)
Olfactory Epithelium, Degeneration 4 (40%) 10 (100%) 10 (100%) 10 (100%) 10 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88045-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY BUTANAL OXIME Date: 09/30/98
Route: GAVAGE Time: 09:43:20
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 25 MG/KG 50 MG/KG 100 200 600
MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10)
Mineralization 7 (70%) 7 (70%)
Nephropathy 1 (10%)
Urinary Bladder (10) (10) (10)
Infiltration Cellular, Lymphocyte 2 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88045-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY BUTANAL OXIME Date: 09/30/98
Route: GAVAGE Time: 09:43:20
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 25 MG/KG 50 MG/KG 100 200 600
MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Natural Death 9
Moribund Sacrifice 1
Survivors
Terminal Sacrifice 10 10 10 10 10
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Rectum (10) (10) (10)
Parasite Metazoan 1 (10%) 1 (10%)
Liver (10) (10) (10) (10) (10) (10)
Hepatodiaphragmatic Nodule 1 (10%) 3 (30%) 2 (20%) 1 (10%)
Inflammation, Chronic Active 2 (20%) 2 (20%) 1 (10%) 3 (30%) 1 (10%)
Necrosis 1 (10%) 10 (100%)
Centrilobular, Vacuolization Cytoplasmic 7 (70%) 1 (10%)
Stomach, Forestomach (10) (10) (10)
Hemorrhage 1 (10%)
Stomach, Glandular (10) (10) (10)
Erosion 2 (20%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (10) (10)
Hemorrhage 1 (10%)
Inflammation, Chronic Active 10 (100%) 9 (90%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Thyroid Gland (10) (10) (10)
Cyst 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88045-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY BUTANAL OXIME Date: 09/30/98
Route: GAVAGE Time: 09:43:20
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 25 MG/KG 50 MG/KG 100 200 600
MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (10) (10) (10)
Hypospermia 10 (100%)
Seminal Vesicle (10) (10) (10)
Atrophy 10 (100%)
Testes (10) (1) (1) (10) (10)
Degeneration, Focal 1 (100%) 1 (100%)
Hypoplasia 9 (90%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (10) (10) (10) (10) (10) (10)
Hyperplasia 10 (100%)
Lymph Node, Mandibular (10) (1) (2) (10) (10)
Atrophy 7 (70%)
Hyperplasia, Plasma Cell 2 (20%) 1 (100%) 2 (100%) 6 (60%)
Lymph Node, Mesenteric (10) (1) (2) (3) (10) (10)
Atrophy 5 (50%)
Hyperplasia, Histiocytic 1 (10%) 1 (100%) 2 (100%) 3 (100%) 1 (10%)
Spleen (10) (10) (10) (10) (10) (10)
Hematopoietic Cell Proliferation 9 (90%) 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Pigmentation 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Capsule, Inflammation, Chronic Active 1 (10%)
Lymphatic, Depletion Cellular 10 (100%)
Thymus (10) (10) (10) (10) (10) (10)
Atrophy 1 (10%)
Hemorrhage 2 (20%)
Necrosis 2 (20%) 10 (100%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88045-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY BUTANAL OXIME Date: 09/30/98
Route: GAVAGE Time: 09:43:20
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 25 MG/KG 50 MG/KG 100 200 600
MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10)
Hemorrhage 2 (20%) 2 (20%)
Inflammation, Chronic Active 2 (20%) 1 (10%)
Nose (10) (10) (10) (10) (10) (10)
Olfactory Epithelium, Degeneration 1 (10%) 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Respiratory Epithelium, Degeneration 1 (10%) 2 (20%) 6 (60%) 8 (80%)
Respiratory Epithelium, Metaplasia, Squamous 9 (90%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10)
Accumulation, Hyaline Droplet 2 (20%)
Inflammation, Chronic Active, Focal 1 (10%)
Nephropathy 6 (60%) 1 (10%) 1 (10%)
Urinary Bladder (10) (10) (10)
Infiltration Cellular, Diffuse, Lymphocyte 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
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