TDMS Study 88045-04 Pathology Tables
NTP Experiment-Test: 88045-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY BUTANAL OXIME Date: 09/30/98
Route: GAVAGE Time: 09:45:53
13 WEEK SUBCHRONIC
Facility: Battelle Columbus Laboratory
Chemical CAS #: 110-69-0
Lock Date: 11/13/96
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 88045-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY BUTANAL OXIME Date: 09/30/98
Route: GAVAGE Time: 09:45:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 25 MG/KG 50 MG/KG 100 200 600
MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Natural Death 9
Survivors
Terminal Sacrifice 10 10 10 10 10 1
Animals Examined Microscopically 10 10 10 10 10 10
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ALIMENTARY SYSTEM
Liver (10) (10) (10) (10) (10) (10)
Inflammation, Chronic Active 3 (30%) 3 (30%) 1 (10%) 1 (10%) 1 (10%)
Necrosis 9 (90%)
Pigmentation 2 (20%)
Tension Lipidosis 1 (10%)
Vacuolization Cytoplasmic 4 (40%) 5 (50%)
Salivary Glands (10) (10) (10)
Inflammation, Chronic Active 1 (10%)
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
Adrenal Cortex (10) (2) (1) (3) (10) (10)
Accessory Adrenal Cortical Nodule 1 (50%) 1 (100%) 1 (33%) 1 (10%)
Vacuolization Cytoplasmic 3 (30%)
Bilateral, Vacuolization Cytoplasmic 2 (20%)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88045-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY BUTANAL OXIME Date: 09/30/98
Route: GAVAGE Time: 09:45:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 25 MG/KG 50 MG/KG 100 200 600
MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (10) (9) (9)
Atrophy 1 (11%)
Lymph Node, Mesenteric (10) (10) (8)
Atrophy 1 (13%)
Spleen (10) (10) (10) (10) (10) (9)
Hematopoietic Cell Proliferation 1 (10%) 1 (10%) 1 (10%) 10 (100%) 2 (22%)
Pigmentation 1 (10%) 10 (100%) 8 (89%)
Lymphatic, Atrophy 7 (78%)
Thymus (9) (10) (10)
Atrophy 8 (80%)
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INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Nose (10) (10) (10) (10) (10) (9)
Exudate, Suppurative 2 (20%) 1 (10%) 5 (56%)
Olfactory Epithelium, Degeneration 8 (80%) 10 (100%) 10 (100%) 9 (100%)
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SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10)
Hydronephrosis 1 (10%)
Urinary Bladder (10) (9) (8)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88045-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY BUTANAL OXIME Date: 09/30/98
Route: GAVAGE Time: 09:45:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 25 MG/KG 50 MG/KG 100 200 600
MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Edema 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88045-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY BUTANAL OXIME Date: 09/30/98
Route: GAVAGE Time: 09:45:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 25 MG/KG 50 MG/KG 100 200 600
MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Natural Death 5
Moribund Sacrifice 1
Dosing Accident 1
Survivors
Terminal Sacrifice 10 10 10 10 10 3
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10) (10) (10)
Mineralization 2 (20%)
Necrosis 7 (70%)
Necrosis, Focal 1 (10%)
Pigmentation 3 (30%)
Vacuolization Cytoplasmic 3 (30%) 5 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (1) (2) (10) (10)
Accessory Adrenal Cortical Nodule 1 (10%)
Subcapsular, Hyperplasia 1 (10%) 2 (20%) 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (10) (10) (10)
Cyst 2 (20%)
Testes (10) (10) (10)
Mineralization 2 (20%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88045-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY BUTANAL OXIME Date: 09/30/98
Route: GAVAGE Time: 09:45:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 25 MG/KG 50 MG/KG 100 200 600
MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (10) (10) (10)
Hyperplasia 1 (10%) 5 (50%)
Lymph Node, Mesenteric (9) (10) (9)
Atrophy 2 (22%)
Spleen (10) (10) (10) (10) (10) (10)
Hematopoietic Cell Proliferation 2 (20%) 10 (100%) 7 (70%)
Pigmentation 10 (100%) 9 (90%)
Lymphatic, Atrophy 7 (70%)
Thymus (9) (10) (8)
Atrophy 4 (50%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (10) (10) (10)
Cranium, Fibrous Osteodystrophy 1 (10%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Nose (10) (10) (10) (10) (10) (10)
Exudate, Suppurative 2 (20%) 10 (100%)
Olfactory Epithelium, Degeneration 2 (20%) 10 (100%) 10 (100%) 10 (100%)
Respiratory Epithelium, Degeneration 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88045-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY BUTANAL OXIME Date: 09/30/98
Route: GAVAGE Time: 09:45:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 25 MG/KG 50 MG/KG 100 200 600
MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Urinary Bladder (10) (10) (8)
Edema 2 (20%) 1 (13%)
a Number of animals examined microscopically at site and number of animals with lesion
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