TDMS Study 88045-04 Pathology Tables
NTP Experiment-Test: 88045-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY BUTANAL OXIME Date: 09/30/98
Route: GAVAGE Time: 09:45:21
13 WEEK SUBCHRONIC
Facility: Battelle Columbus Laboratory
Chemical CAS #: 110-69-0
Lock Date: 11/13/96
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 88045-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY BUTANAL OXIME Date: 09/30/98
Route: GAVAGE Time: 09:45:21
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + | 9 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 88045-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY BUTANAL OXIME Date: 09/30/98
Route: GAVAGE Time: 09:45:21
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + + + + + M + + + + | 9 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 88045-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY BUTANAL OXIME Date: 09/30/98
Route: GAVAGE Time: 09:45:21
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
25 MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 88045-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY BUTANAL OXIME Date: 09/30/98
Route: GAVAGE Time: 09:45:21
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
50 MG/KG | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + | 1 |
Teratoma Benign | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 88045-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY BUTANAL OXIME Date: 09/30/98
Route: GAVAGE Time: 09:45:21
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
100 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 88045-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY BUTANAL OXIME Date: 09/30/98
Route: GAVAGE Time: 09:45:21
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
200 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + M + + + + M + M | 7 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + | 9 |
__________________________________________________________________________|____________|
Pituitary Gland | + M M M + M + + M M | 4 |
__________________________________________________________________________|____________|
Thyroid Gland | + + M + + + + + + + | 9 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M + + + + | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 88045-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY BUTANAL OXIME Date: 09/30/98
Route: GAVAGE Time: 09:45:21
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
200 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + M + | 9 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 88045-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY BUTANAL OXIME Date: 09/30/98
Route: GAVAGE Time: 09:45:21
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 1| 0| 2| 8| 9| 1| 2| 2| 1| 5| | |
| 5| 5| 2| 5| 3| 4| 1| 1| 5| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
600 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Gallbladder | A M A A + M + + A A | 3 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + M + A + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A + + + + M + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + M + A + A + + A A | 5 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + M A A + + + A M + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A M A A + M + A M + | 3 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A M A A + + + + A + | 5 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Pancreas | + A + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + A A A + + + + + + | 7 |
__________________________________________________________________________|____________|
Stomach, Glandular | + A A A + + + + + + | 7 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + A + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + M M M M + M + | 3 |
__________________________________________________________________________|____________|
Pituitary Gland | + + M + + + + + + + | 9 |
__________________________________________________________________________|____________|
Thyroid Gland | + M + M + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + M + + M + | 8 |
__________________________________________________________________________|____________|
Ovary | + A + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Uterus | + A + + + + + + + + | 9 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + A + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + A + + + + + A + | 8 |
__________________________________________________________________________|____________|
Spleen | + A + + + + + + + + | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 88045-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY BUTANAL OXIME Date: 09/30/98
Route: GAVAGE Time: 09:45:21
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 1| 0| 2| 8| 9| 1| 2| 2| 1| 5| | |
| 5| 5| 2| 5| 3| 4| 1| 1| 5| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
600 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + + + + + + | 9 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Nose | + A + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + A + + + A + + + + | 8 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 88045-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY BUTANAL OXIME Date: 09/30/98
Route: GAVAGE Time: 09:45:21
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0 MG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + M + M + + M | 6 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + + + + + + | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 88045-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY BUTANAL OXIME Date: 09/30/98
Route: GAVAGE Time: 09:45:21
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0 MG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + | 9 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M + M | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 88045-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY BUTANAL OXIME Date: 09/30/98
Route: GAVAGE Time: 09:45:21
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
25 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 88045-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY BUTANAL OXIME Date: 09/30/98
Route: GAVAGE Time: 09:45:21
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
50 MG/KG | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 88045-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY BUTANAL OXIME Date: 09/30/98
Route: GAVAGE Time: 09:45:21
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
100 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 88045-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY BUTANAL OXIME Date: 09/30/98
Route: GAVAGE Time: 09:45:21
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
200 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M + + + + + + | 8 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + M + + + | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 88045-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY BUTANAL OXIME Date: 09/30/98
Route: GAVAGE Time: 09:45:21
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
200 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 88045-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY BUTANAL OXIME Date: 09/30/98
Route: GAVAGE Time: 09:45:21
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 8| 9| 4| 8| 5| 9| 1| 6| 5| | |
| 3| 7| 3| 6| 7| 8| 3| 0| 2| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
600 | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Gallbladder | + A + A + + + A A + | 6 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + A + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + A + + + A A + | 6 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + A + + + A A + | 6 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + A M + + A + + | 6 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + A A + | 8 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + M + + M + | 7 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thyroid Gland | + + M + + + + + + + | 9 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 88045-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY BUTANAL OXIME Date: 09/30/98
Route: GAVAGE Time: 09:45:21
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 8| 9| 4| 8| 5| 9| 1| 6| 5| | |
| 3| 7| 3| 6| 7| 8| 3| 0| 2| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
600 | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + A + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thymus | + A + + + + + + M + | 8 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + M M M M M M M | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + A + A + + + + + + | 8 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
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---------- END OF REPORT ----------
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