TDMS Study 88050-05 Pathology Tables
NTP Experiment-Test: 88050-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC METHACRYLONITRILE Date: 02/24/00 Route: GAVAGE Time: 14:18:49 FINAL#1 2 YEAR CHRONIC RATS Facility: Battelle Columbus Laboratory Chemical CAS #: 126-98-7 Lock Date: 05/05/99 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 88050-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC METHACRYLONITRILE Date: 02/24/00 Route: GAVAGE Time: 14:18:49 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 50 Early Deaths Moribund Sacrifice 4 10 9 7 Natural Death 7 6 6 7 Dosing Accident 1 1 1 Survivors Terminal Sacrifice 38 33 34 35 Natural Death 1 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Esophagus (50) (50) (50) (50) Periesophageal Tissue, Hemorrhage 1 (2%) 2 (4%) Intestine Large, Rectum (50) (50) (50) (50) Parasite Metazoan 2 (4%) 5 (10%) 5 (10%) 4 (8%) Intestine Large, Cecum (50) (50) (50) (50) Inflammation, Chronic Active 1 (2%) Intestine Small, Duodenum (50) (50) (50) (50) Fibrosis 1 (2%) Liver (50) (49) (48) (50) Angiectasis 1 (2%) 2 (4%) 1 (2%) Basophilic Focus 43 (86%) 43 (88%) 35 (73%) 39 (78%) Clear Cell Focus 4 (8%) 2 (4%) 1 (2%) 3 (6%) Degeneration 1 (2%) Degeneration, Cystic 1 (2%) 1 (2%) Eosinophilic Focus 3 (6%) Fatty Change 21 (42%) 13 (27%) 11 (23%) 7 (14%) Hepatodiaphragmatic Nodule 9 (18%) 7 (14%) 8 (17%) 12 (24%) Hyperplasia 1 (2%) Inflammation, Chronic Active 31 (62%) 27 (55%) 27 (56%) 27 (54%) Mixed Cell Focus 2 (4%) 7 (14%) 8 (17%) 5 (10%) Necrosis 2 (4%) 3 (6%) 1 (2%) Thrombosis 2 (4%) 3 (6%) Vacuolization Cytoplasmic 7 (14%) 14 (29%) 17 (35%) 30 (60%) Bile Duct, Hyperplasia 14 (28%) 5 (10%) 13 (27%) 9 (18%) Mesentery (7) (2) (8) (4) Fat, Inflammation, Chronic Active 5 (71%) 1 (50%) 2 (25%) 1 (25%) Fat, Necrosis 1 (14%) 1 (50%) 4 (50%) 2 (50%) Pancreas (50) (50) (50) (50) Cytoplasmic Alteration 1 (2%) Hyperplasia 1 (2%) 1 (2%) 1 (2%) Acinus, Atrophy 8 (16%) 4 (8%) 7 (14%) 10 (20%) Stomach, Forestomach (50) (50) (50) (50) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88050-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC METHACRYLONITRILE Date: 02/24/00 Route: GAVAGE Time: 14:18:49 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Edema 1 (2%) 1 (2%) Hyperplasia 1 (2%) 1 (2%) 1 (2%) Inflammation, Chronic Active 1 (2%) 2 (4%) 1 (2%) Ulcer 1 (2%) Stomach, Glandular (50) (50) (50) (50) Erosion 1 (2%) 1 (2%) 2 (4%) 5 (10%) Mineralization 1 (2%) Ulcer 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (50) (50) (50) Cardiomyopathy 24 (48%) 19 (38%) 16 (32%) 21 (42%) Fibrosis 1 (2%) Thrombosis 1 (2%) 2 (4%) 1 (2%) Epicardium, Inflammation, Chronic Active 1 (2%) Pericardium, Inflammation, Chronic Active 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (50) (50) (50) Angiectasis 23 (46%) 6 (12%) 12 (24%) 19 (38%) Degeneration 1 (2%) Hemorrhage 1 (2%) Hyperplasia 7 (14%) 6 (12%) 10 (20%) 7 (14%) Hypertrophy 1 (2%) Necrosis 2 (4%) Thrombosis 1 (2%) Vacuolization Cytoplasmic 4 (8%) 1 (2%) 2 (4%) 6 (12%) Capsule, Fibrosis 1 (2%) Adrenal Medulla (50) (50) (50) (50) Hyperplasia 2 (4%) 3 (6%) 1 (2%) Pituitary Gland (50) (50) (50) (50) Angiectasis 6 (12%) 4 (8%) 3 (6%) 5 (10%) Cyst 19 (38%) 13 (26%) 14 (28%) 15 (30%) Hyperplasia 20 (40%) 23 (46%) 16 (32%) 16 (32%) Craniopharyngeal Duct, Hyperplasia 1 (2%) Pars Nervosa, Hyperplasia 1 (2%) Thyroid Gland (50) (50) (50) (50) C-Cell, Hyperplasia 36 (72%) 25 (50%) 37 (74%) 32 (64%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88050-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC METHACRYLONITRILE Date: 02/24/00 Route: GAVAGE Time: 14:18:49 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (49) (48) (50) (48) Cyst 1 (2%) 4 (8%) 5 (10%) 1 (2%) Hyperplasia 10 (20%) 7 (15%) 10 (20%) 2 (4%) Inflammation, Chronic Active 6 (12%) 2 (4%) 5 (10%) 8 (17%) Ovary (50) (50) (50) (50) Atrophy 1 (2%) Cyst 1 (2%) Mineralization 1 (2%) Follicle, Cyst 3 (6%) 1 (2%) 1 (2%) 1 (2%) Periovarian Tissue, Cyst 4 (8%) 3 (6%) 2 (4%) 3 (6%) Uterus (50) (50) (50) (50) Hemorrhage 1 (2%) Hydrometra 2 (4%) 2 (4%) 2 (4%) 2 (4%) Inflammation, Chronic Active 2 (4%) Cervix, Fibrosis 1 (2%) 1 (2%) 1 (2%) Cervix, Inflammation, Chronic Active 3 (6%) 1 (2%) Endometrium, Hyperplasia, Cystic 4 (8%) 1 (2%) 3 (6%) 3 (6%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (50) (50) (50) Atrophy 1 (2%) 1 (2%) 1 (2%) Hyperplasia 12 (24%) 11 (22%) 12 (24%) 25 (50%) Myelofibrosis 1 (2%) Lymph Node (6) (1) (5) (1) Mediastinal, Hyperplasia 1 (20%) Lymph Node, Mandibular (50) (49) (50) (50) Ectasia 1 (2%) 1 (2%) 1 (2%) Hyperplasia 1 (2%) Lymph Node, Mesenteric (50) (50) (50) (50) Ectasia 1 (2%) 1 (2%) Spleen (50) (50) (50) (50) Accessory Spleen 1 (2%) Fibrosis 1 (2%) 1 (2%) 1 (2%) Hematopoietic Cell Proliferation 1 (2%) 8 (16%) 7 (14%) 5 (10%) Capsule, Necrosis 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88050-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC METHACRYLONITRILE Date: 02/24/00 Route: GAVAGE Time: 14:18:49 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (50) (50) (50) (50) Galactocele 13 (26%) 9 (18%) 9 (18%) 9 (18%) Hyperplasia 8 (16%) 11 (22%) 9 (18%) 6 (12%) Inflammation, Chronic Active 1 (2%) Skin (50) (50) (50) (50) Parakeratosis 1 (2%) Ulcer 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (50) (50) Osteosclerosis 1 (2%) 1 (2%) 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (50) (50) Hemorrhage 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (50) (50) (50) Congestion 1 (2%) Hemorrhage 1 (2%) 2 (4%) Inflammation, Chronic Active 5 (10%) 4 (8%) 4 (8%) 4 (8%) Necrosis 1 (2%) Pigmentation 1 (2%) Alveolar Epithelium, Hyperplasia 6 (12%) 3 (6%) 4 (8%) 6 (12%) Mediastinum, Inflammation 1 (2%) Nose (50) (50) (50) (50) Inflammation 1 (2%) Inflammation, Chronic Active 1 (2%) 2 (4%) 1 (2%) Thrombosis 3 (6%) 1 (2%) 2 (4%) Olfactory Epithelium, Atrophy 1 (2%) 19 (38%) Olfactory Epithelium, Metaplasia 47 (94%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (4) (1) (3) (1) Cataract 4 (100%) 1 (100%) 3 (100%) 1 (100%) Lens, Mineralization 3 (75%) 2 (67%) Retina, Degeneration 3 (75%) 1 (100%) 3 (100%) 1 (100%) Zymbal's Gland (1) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88050-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC METHACRYLONITRILE Date: 02/24/00 Route: GAVAGE Time: 14:18:49 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - CONT Inflammation, Chronic Active 1 (100%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (50) (50) Accumulation, Hyaline Droplet 2 (4%) 1 (2%) Congestion 1 (2%) Hydronephrosis 1 (2%) Inflammation, Chronic Active 3 (6%) 9 (18%) 5 (10%) 3 (6%) Necrosis 1 (2%) Nephropathy 29 (58%) 27 (54%) 29 (58%) 25 (50%) Pigmentation 3 (6%) 3 (6%) 2 (4%) Renal Tubule, Hyperplasia 1 (2%) Urinary Bladder (50) (50) (50) (50) Hemorrhage 1 (2%) Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%) Transitional Epithelium, Hyperplasia 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88050-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC METHACRYLONITRILE Date: 02/24/00 Route: GAVAGE Time: 14:18:49 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 50 Early Deaths Natural Death 12 3 6 6 Moribund Sacrifice 13 13 9 12 Dosing Accident 1 Survivors Natural Death 1 Terminal Sacrifice 25 34 34 31 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Colon (50) (50) (50) (50) Inflammation, Chronic Active 1 (2%) Parasite Metazoan 1 (2%) 1 (2%) Pigmentation 1 (2%) Intestine Large, Rectum (50) (50) (50) (50) Parasite Metazoan 10 (20%) 8 (16%) 7 (14%) 5 (10%) Intestine Large, Cecum (49) (50) (50) (50) Inflammation, Chronic Active 1 (2%) Epithelium, Atrophy 1 (2%) Intestine Small, Duodenum (50) (50) (50) (50) Inflammation, Chronic Active 1 (2%) 1 (2%) Parasite Metazoan 1 (2%) Intestine Small, Jejunum (50) (50) (50) (50) Inflammation, Chronic Active 2 (4%) Intestine Small, Ileum (50) (50) (49) (50) Inflammation, Chronic Active 2 (4%) Parasite Metazoan 1 (2%) Liver (50) (50) (50) (49) Angiectasis 2 (4%) 4 (8%) 7 (14%) 4 (8%) Basophilic Focus 26 (52%) 33 (66%) 35 (70%) 13 (27%) Clear Cell Focus 8 (16%) 16 (32%) 16 (32%) 4 (8%) Congestion 1 (2%) 1 (2%) Cyst 1 (2%) Degeneration, Cystic 3 (6%) 7 (14%) 5 (10%) 6 (12%) Eosinophilic Focus 10 (20%) 8 (16%) 9 (18%) 7 (14%) Fatty Change 23 (46%) 18 (36%) 21 (42%) 9 (18%) Hematopoietic Cell Proliferation 1 (2%) Hepatodiaphragmatic Nodule 8 (16%) 5 (10%) 9 (18%) 6 (12%) Inclusion Body Intracytoplasmic 1 (2%) Inflammation, Chronic Active 16 (32%) 21 (42%) 29 (58%) 10 (20%) Mixed Cell Focus 16 (32%) 23 (46%) 22 (44%) 10 (20%) Necrosis 4 (8%) 1 (2%) 3 (6%) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88050-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC METHACRYLONITRILE Date: 02/24/00 Route: GAVAGE Time: 14:18:49 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Thrombosis 1 (2%) Vacuolization Cytoplasmic 14 (28%) 18 (36%) 23 (46%) 28 (57%) Bile Duct, Fibrosis 1 (2%) Bile Duct, Hyperplasia 42 (84%) 48 (96%) 48 (96%) 36 (73%) Mesentery (13) (13) (11) (12) Artery, Inflammation, Chronic Active 1 (8%) Fat, Inflammation, Chronic Active 8 (62%) 12 (92%) 11 (100%) 9 (75%) Fat, Mineralization 1 (8%) Fat, Necrosis 1 (8%) 1 (8%) 1 (8%) Pancreas (50) (49) (50) (50) Cytoplasmic Alteration 2 (4%) 3 (6%) Fibrosis 1 (2%) Hyperplasia 4 (8%) 10 (20%) 11 (22%) 12 (24%) Acinus, Atrophy 10 (20%) 13 (27%) 12 (24%) 14 (28%) Artery, Inflammation, Chronic Active 1 (2%) 1 (2%) Stomach, Forestomach (50) (50) (50) (50) Erosion 1 (2%) Hyperkeratosis 1 (2%) Hyperplasia 3 (6%) 3 (6%) 1 (2%) Inflammation, Chronic Active 1 (2%) 1 (2%) Perforation 1 (2%) Ulcer 2 (4%) 2 (4%) 2 (4%) Epithelium, Hyperplasia 1 (2%) Stomach, Glandular (50) (50) (50) (50) Erosion 3 (6%) 5 (10%) 2 (4%) Mineralization 1 (2%) Ulcer 4 (8%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Blood Vessel (50) (49) (50) (50) Inflammation, Chronic Active 1 (2%) 1 (2%) Heart (50) (50) (50) (50) Cardiomyopathy 43 (86%) 48 (96%) 41 (82%) 46 (92%) Fibrosis 1 (2%) 1 (2%) Thrombosis 3 (6%) 1 (2%) 1 (2%) 3 (6%) Artery, Inflammation, Chronic Active 1 (2%) Endocardium, Hyperplasia 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (50) (50) (50) Angiectasis 5 (10%) 3 (6%) 12 (24%) 9 (18%) Atrophy 1 (2%) 1 (2%) Degeneration, Cystic 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88050-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC METHACRYLONITRILE Date: 02/24/00 Route: GAVAGE Time: 14:18:49 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Hematopoietic Cell Proliferation 2 (4%) Hyperplasia 9 (18%) 10 (20%) 11 (22%) 8 (16%) Necrosis 1 (2%) Pigmentation 1 (2%) Thrombosis 1 (2%) Vacuolization Cytoplasmic 8 (16%) 3 (6%) 3 (6%) 5 (10%) Adrenal Medulla (50) (50) (50) (50) Hyperplasia 11 (22%) 5 (10%) 7 (14%) 7 (14%) Mineralization 1 (2%) Islets, Pancreatic (50) (50) (50) (50) Hyperplasia 1 (2%) 1 (2%) 1 (2%) Parathyroid Gland (46) (46) (50) (50) Fibrosis 1 (2%) Hyperplasia, Focal 1 (2%) Pituitary Gland (50) (50) (50) (50) Angiectasis 2 (4%) 3 (6%) Atrophy 1 (2%) 1 (2%) Cyst 5 (10%) 5 (10%) 7 (14%) 1 (2%) Hyperplasia 13 (26%) 17 (34%) 16 (32%) 10 (20%) Craniopharyngeal Duct, Hyperplasia 1 (2%) Thyroid Gland (50) (50) (50) (50) C-Cell, Hyperplasia 23 (46%) 29 (58%) 35 (70%) 29 (58%) Follicle, Cyst 1 (2%) Follicular Cell, Hyperplasia 3 (6%) 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (50) (50) (50) (50) Inflammation, Chronic Active 1 (2%) 1 (2%) Preputial Gland (50) (50) (50) (49) Hyperplasia 1 (2%) 1 (2%) 1 (2%) Inflammation, Chronic Active 41 (82%) 45 (90%) 46 (92%) 45 (92%) Prostate (50) (50) (50) (50) Atrophy 1 (2%) 1 (2%) 3 (6%) Cyst 1 (2%) Hyperplasia 5 (10%) 2 (4%) Inflammation 25 (50%) 25 (50%) 17 (34%) 24 (48%) Seminal Vesicle (50) (50) (50) (50) Atrophy 1 (2%) 2 (4%) 1 (2%) 4 (8%) Inflammation, Chronic Active 1 (2%) Testes (50) (50) (50) (50) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88050-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC METHACRYLONITRILE Date: 02/24/00 Route: GAVAGE Time: 14:18:49 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM - CONT Atrophy 6 (12%) 6 (12%) 5 (10%) 2 (4%) Mineralization 1 (2%) Necrosis 1 (2%) Interstitial Cell, Hyperplasia 9 (18%) 6 (12%) 4 (8%) 3 (6%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (50) (50) (50) Hyperplasia 17 (34%) 14 (28%) 19 (38%) 20 (40%) Myelofibrosis 1 (2%) Lymph Node (7) (3) (3) (4) Mediastinal, Congestion 1 (14%) Mediastinal, Ectasia 1 (33%) Mediastinal, Inflammation, Chronic Active 1 (33%) Renal, Congestion 1 (33%) Renal, Ectasia 1 (33%) Renal, Inflammation, Chronic Active 1 (33%) Lymph Node, Mandibular (49) (50) (49) (49) Ectasia 1 (2%) 4 (8%) 1 (2%) 4 (8%) Hyperplasia 1 (2%) Hyperplasia, Plasma Cell 2 (4%) 1 (2%) 2 (4%) Lymph Node, Mesenteric (50) (50) (50) (50) Congestion 1 (2%) Ectasia 2 (4%) 3 (6%) 1 (2%) 4 (8%) Inflammation, Chronic Active 2 (4%) Spleen (50) (50) (50) (49) Accessory Spleen 1 (2%) Angiectasis 1 (2%) Fibrosis 6 (12%) 4 (8%) 4 (8%) 4 (8%) Hematopoietic Cell Proliferation 4 (8%) 3 (6%) 3 (6%) 7 (14%) Hemorrhage 1 (2%) Hyperplasia, Histiocytic 1 (2%) Necrosis 1 (2%) 1 (2%) 1 (2%) Capsule, Fibrosis 1 (2%) Capsule, Inflammation, Chronic Active 1 (2%) Thymus (49) (47) (45) (50) Cyst 1 (2%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (46) (50) (49) (49) Galactocele 5 (10%) 1 (2%) Hyperplasia 2 (4%) 3 (6%) 4 (8%) 4 (8%) Skin (49) (50) (50) (50) Cyst Epithelial Inclusion 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88050-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC METHACRYLONITRILE Date: 02/24/00 Route: GAVAGE Time: 14:18:49 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - CONT Hyperkeratosis 2 (4%) 1 (2%) Hyperplasia 2 (4%) Inflammation, Chronic Active 1 (2%) 1 (2%) Parakeratosis 1 (2%) Subcutaneous Tissue, Fibrosis 1 (2%) Subcutaneous Tissue, Inflammation, Chronic Active 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (50) (50) Hydrocephalus 1 (2%) Necrosis 2 (4%) 1 (2%) Artery, Inflammation, Chronic Active 1 (2%) Spinal Cord (1) (2) (1) (1) Hemorrhage 1 (100%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (50) (50) (50) Angiectasis 1 (2%) Congestion 2 (4%) 1 (2%) Edema 1 (2%) Hemorrhage 4 (8%) 2 (4%) Inflammation, Chronic Active 3 (6%) 3 (6%) 4 (8%) 6 (12%) Leukocytosis 1 (2%) Alveolar Epithelium, Hyperplasia 3 (6%) 8 (16%) 6 (12%) 4 (8%) Nose (50) (50) (49) (50) Abscess 1 (2%) Inflammation, Chronic Active 6 (12%) 7 (14%) 6 (12%) 6 (12%) Thrombosis 2 (4%) 1 (2%) 1 (2%) Olfactory Epithelium, Atrophy 48 (96%) Olfactory Epithelium, Metaplasia 47 (94%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88050-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC METHACRYLONITRILE Date: 02/24/00 Route: GAVAGE Time: 14:18:49 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (1) (1) Cataract 1 (100%) Degeneration 1 (100%) Lens, Mineralization 1 (100%) Retina, Atrophy 1 (100%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (50) (50) Cyst 2 (4%) 1 (2%) Fibrosis 1 (2%) Infarct 1 (2%) 1 (2%) Inflammation, Chronic Active 13 (26%) 25 (50%) 22 (44%) 18 (36%) Mineralization 1 (2%) Nephropathy 44 (88%) 48 (96%) 46 (92%) 47 (94%) Pigmentation 2 (4%) 3 (6%) 1 (2%) Urinary Bladder (50) (50) (50) (50) Hemorrhage 1 (2%) 1 (2%) Inflammation, Chronic Active 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------