TDMS Study 88050-05 Pathology Tables
NTP Experiment-Test: 88050-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC METHACRYLONITRILE Date: 02/24/00
Route: GAVAGE Time: 14:18:54
FINAL#1 2 YEAR CHRONIC RATS
Facility: Battelle Columbus Laboratory
Chemical CAS #: 126-98-7
Lock Date: 05/05/99
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88050-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC METHACRYLONITRILE Date: 02/24/00
Route: GAVAGE Time: 14:18:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG
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DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 4 10 9 7
Natural Death 7 6 6 7
Dosing Accident 1 1 1
Survivors
Terminal Sacrifice 38 33 34 35
Natural Death 1
Animals Examined Microscopically 50 50 50 50
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ALIMENTARY SYSTEM
Esophagus (50) (50) (50) (50)
Periesophageal Tissue, Lipoma 1 (2%)
Intestine Large, Colon (50) (50) (50) (50)
Polyp Adenomatous 1 (2%) 1 (2%)
Intestine Small, Duodenum (50) (50) (50) (50)
Intestine Small, Ileum (50) (50) (50) (50)
Liver (50) (49) (48) (50)
Hepatocellular Adenoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Mesentery (7) (2) (8) (4)
Lipoma 1 (25%)
Fat, Histiocytic Sarcoma 1 (13%)
Pancreas (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Salivary Glands (50) (50) (50) (50)
Stomach, Glandular (50) (50) (50) (50)
Adenoma 1 (2%)
Tongue (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (49) (50) (50) (50)
Heart (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 88050-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC METHACRYLONITRILE Date: 02/24/00
Route: GAVAGE Time: 14:18:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Adenoma 1 (2%)
Adrenal Medulla (50) (50) (50) (50)
Pheochromocytoma Benign 1 (2%) 3 (6%) 2 (4%) 1 (2%)
Islets, Pancreatic (50) (50) (50) (50)
Adenoma 1 (2%) 1 (2%)
Parathyroid Gland (48) (47) (46) (47)
Adenoma 1 (2%)
Pituitary Gland (50) (50) (50) (50)
Adenoma 12 (24%) 14 (28%) 19 (38%) 14 (28%)
Carcinoma 1 (2%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (50) (50) (50) (50)
Bilateral, C-Cell, Adenoma 1 (2%)
C-Cell, Adenoma 3 (6%) 8 (16%) 5 (10%) 7 (14%)
C-Cell, Carcinoma 2 (4%) 1 (2%) 1 (2%)
Follicular Cell, Carcinoma 1 (2%)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Clitoral Gland (49) (48) (50) (48)
Adenoma 2 (4%)
Carcinoma 1 (2%) 2 (4%) 1 (2%)
Hemangiosarcoma 1 (2%)
Ovary (50) (50) (50) (50)
Granulosa Cell Tumor Malignant 1 (2%)
Histiocytic Sarcoma 1 (2%)
Uterus (50) (50) (50) (50)
Adenoma 1 (2%)
Carcinoma 1 (2%)
Deciduoma Benign 1 (2%)
Leiomyosarcoma 1 (2%)
Polyp Stromal 6 (12%) 8 (16%) 9 (18%) 8 (16%)
Polyp Stromal, Multiple 3 (6%)
Sarcoma Stromal 1 (2%) 2 (4%)
Cervix, Polyp Stromal 1 (2%)
Cervix, Sarcoma Stromal 1 (2%)
Vagina (2)
Leiomyoma 1 (50%)
Sarcoma Stromal 1 (50%)
NTP Experiment-Test: 88050-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC METHACRYLONITRILE Date: 02/24/00
Route: GAVAGE Time: 14:18:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Lymph Node (6) (1) (5) (1)
Lymph Node, Mandibular (50) (49) (50) (50)
Carcinoma, Metastatic, Mammary Gland 1 (2%)
Lymph Node, Mesenteric (50) (50) (50) (50)
Spleen (50) (50) (50) (50)
Thymus (48) (49) (47) (47)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Adenoma 1 (2%)
Carcinoma 3 (6%) 1 (2%) 1 (2%) 1 (2%)
Fibroadenoma 16 (32%) 17 (34%) 10 (20%) 16 (32%)
Fibroadenoma, Multiple 5 (10%) 9 (18%) 9 (18%) 2 (4%)
Skin (50) (50) (50) (50)
Basal Cell Adenoma 1 (2%) 1 (2%)
Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Fibroma 2 (4%)
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Carcinoma, Metastatic, Pituitary Gland 1 (2%)
Glioma Malignant 1 (2%)
Oligodendroglioma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 2 (4%)
Carcinoma, Metastatic, Mammary Gland 1 (2%) 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 2 (4%)
Histiocytic Sarcoma 1 (2%)
Nephroblastoma, Metastatic, Kidney 1 (2%)
NTP Experiment-Test: 88050-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC METHACRYLONITRILE Date: 02/24/00
Route: GAVAGE Time: 14:18:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Adenoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Nephroblastoma 1 (2%)
Urinary Bladder (50) (50) (50) (50)
Transitional Epithelium, Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 21 (42%) 19 (38%) 16 (32%) 19 (38%)
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* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 88050-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC METHACRYLONITRILE Date: 02/24/00
Route: GAVAGE Time: 14:18:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 45 45 42 46
Total Primary Neoplasms 84 88 79 89
Total Animals with Benign Neoplasms 35 38 34 37
Total Benign Neoplasms 53 63 57 64
Total Animals with Malignant Neoplasms 26 21 21 24
Total Malignant Neoplasms 31 25 22 25
Total Animals with Metastatic Neoplasms 5 1 1
Total Metastatic Neoplasm 5 1 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
NTP Experiment-Test: 88050-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC METHACRYLONITRILE Date: 02/24/00
Route: GAVAGE Time: 14:18:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Natural Death 12 3 6 6
Moribund Sacrifice 13 13 9 12
Dosing Accident 1
Survivors
Natural Death 1
Terminal Sacrifice 25 34 34 31
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (50) (50) (50)
Polyp Adenomatous 1 (2%) 1 (2%)
Intestine Large, Rectum (50) (50) (50) (50)
Polyp Adenomatous 1 (2%) 1 (2%)
Intestine Small, Duodenum (50) (50) (50) (50)
Polyp Adenomatous 1 (2%)
Intestine Small, Jejunum (50) (50) (50) (50)
Polyp Adenomatous 1 (2%)
Liver (50) (50) (50) (49)
Hepatocellular Adenoma 1 (2%) 2 (4%)
Histiocytic Sarcoma 1 (2%)
Mesentery (13) (13) (11) (12)
Fat, Sarcoma 1 (8%)
Fat, Schwannoma Malignant 1 (8%)
Pancreas (50) (49) (50) (50)
Adenoma 2 (4%) 1 (2%) 2 (4%)
Mixed Tumor Benign 1 (2%)
Salivary Glands (50) (50) (50) (50)
Neural Crest Tumor 1 (2%)
Schwannoma Malignant 2 (4%) 1 (2%) 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (50) (50) (50) (50)
Carcinoma 1 (2%)
Tongue (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 88050-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC METHACRYLONITRILE Date: 02/24/00
Route: GAVAGE Time: 14:18:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Adenoma 1 (2%) 2 (4%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Adrenal Medulla (50) (50) (50) (50)
Osteosarcoma, Metastatic, Bone 1 (2%)
Pheochromocytoma Malignant 1 (2%) 1 (2%) 2 (4%)
Pheochromocytoma Benign 2 (4%) 6 (12%) 6 (12%) 2 (4%)
Bilateral, Pheochromocytoma Benign 1 (2%) 1 (2%)
Islets, Pancreatic (50) (50) (50) (50)
Adenoma 2 (4%) 1 (2%) 1 (2%)
Carcinoma 2 (4%)
Parathyroid Gland (46) (46) (50) (50)
Adenoma 1 (2%) 1 (2%)
Pituitary Gland (50) (50) (50) (50)
Adenoma 17 (34%) 18 (36%) 11 (22%) 20 (40%)
Craniopharyngioma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Thyroid Gland (50) (50) (50) (50)
Schwannoma Malignant, Metastatic, Skin 1 (2%)
Bilateral, C-Cell, Adenoma 1 (2%) 2 (4%) 1 (2%)
C-Cell, Adenoma 8 (16%) 10 (20%) 7 (14%) 6 (12%)
C-Cell, Carcinoma 1 (2%) 1 (2%) 1 (2%)
Follicular Cell, Adenoma 1 (2%) 2 (4%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%) 2 (4%)
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GENERAL BODY SYSTEM
Tissue NOS (1) (1)
Chemodectoma Benign 1 (100%)
Osteosarcoma, Metastatic, Bone 1 (100%)
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NTP Experiment-Test: 88050-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC METHACRYLONITRILE Date: 02/24/00
Route: GAVAGE Time: 14:18:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Preputial Gland (50) (50) (50) (49)
Adenoma 2 (4%) 1 (2%) 4 (8%) 4 (8%)
Carcinoma 1 (2%) 1 (2%) 3 (6%) 2 (4%)
Prostate (50) (50) (50) (50)
Adenoma 1 (2%) 1 (2%)
Seminal Vesicle (50) (50) (50) (50)
Testes (50) (50) (50) (50)
Hemangiosarcoma 1 (2%)
Bilateral, Interstitial Cell, Adenoma 34 (68%) 40 (80%) 43 (86%) 45 (90%)
Interstitial Cell, Adenoma 6 (12%) 5 (10%) 4 (8%) 1 (2%)
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HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Lymph Node (7) (3) (3) (4)
Osteosarcoma, Metastatic, Bone 1 (33%)
Inguinal, Fibrosarcoma, Metastatic, Skin 1 (25%)
Mediastinal, Histiocytic Sarcoma 1 (25%)
Lymph Node, Mandibular (49) (50) (49) (49)
Neural Crest Tumor, Metastatic, Lymph Node,
Mandibular 1 (2%)
Lymph Node, Mesenteric (50) (50) (50) (50)
Carcinoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Spleen (50) (50) (50) (49)
Hemangiosarcoma 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Leiomyoma 1 (2%)
Thymus (49) (47) (45) (50)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (46) (50) (49) (49)
Fibroadenoma 2 (4%) 6 (12%) 2 (4%) 8 (16%)
Fibroadenoma, Multiple 1 (2%)
Skin (49) (50) (50) (50)
Basal Cell Adenoma 1 (2%)
Basal Cell Carcinoma 1 (2%)
Carcinoma, Metastatic, Nose 1 (2%)
Hemangiosarcoma 1 (2%)
Keratoacanthoma 4 (8%) 3 (6%) 2 (4%)
Keratoacanthoma, Multiple 1 (2%) 1 (2%)
NTP Experiment-Test: 88050-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC METHACRYLONITRILE Date: 02/24/00
Route: GAVAGE Time: 14:18:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Sarcoma 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Subcutaneous Tissue, Fibroma 3 (6%) 3 (6%) 2 (4%) 5 (10%)
Subcutaneous Tissue, Fibroma, Multiple 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 2 (4%)
Subcutaneous Tissue, Fibrous Histiocytoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Neural Crest Tumor,
Metastatic, Skin 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant,
Metastatic, Salivary Glands 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Osteoma 1 (2%)
Cranium, Osteosarcoma 1 (2%)
Vertebra, Osteosarcoma 1 (2%)
Skeletal Muscle (1) (1)
Rhabdomyosarcoma 1 (100%)
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NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Astrocytoma Malignant 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Oligodendroglioma Malignant 1 (2%)
Meninges, Osteosarcoma, Metastatic, Bone 1 (2%)
Spinal Cord (1) (2) (1) (1)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 3 (6%) 1 (2%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (2%)
Schwannoma Malignant, Metastatic, Skin 1 (2%)
Mediastinum, Osteosarcoma, Metastatic, Bone 1 (2%)
Nose (50) (50) (49) (50)
Osteosarcoma, Metastatic, Bone 1 (2%)
Respiratory Epithelium, Squamous Cell
NTP Experiment-Test: 88050-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC METHACRYLONITRILE Date: 02/24/00
Route: GAVAGE Time: 14:18:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (2) (1)
Adenoma 1 (50%)
Carcinoma 1 (50%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Renal Tubule, Adenoma 1 (2%) 1 (2%)
Urinary Bladder (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 20 (40%) 20 (40%) 14 (28%) 12 (24%)
Mesothelioma Malignant 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 11
NTP Experiment-Test: 88050-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC METHACRYLONITRILE Date: 02/24/00
Route: GAVAGE Time: 14:18:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 50 49 49
Total Primary Neoplasms 116 146 124 133
Total Animals with Benign Neoplasms 47 49 49 47
Total Benign Neoplasms 85 114 95 104
Total Animals with Malignant Neoplasms 29 30 24 26
Total Malignant Neoplasms 31 32 29 28
Total Animals with Metastatic Neoplasms 3 2 1 4
Total Metastatic Neoplasm 5 10 1 5
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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