TDMS Study 88050-05 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11 LAB: Battelle Columbus METHACRYLONITRILE DATE: 02/24/00 EXPERIMENT: 88050 TEST: 05 TIME: 14:26:23 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1 CONT: NO1-ES-55388 ROUTE: GAVAGE NTP C#: 88050B PATHOLOGIST: YARRINGTON, JOHN CAS: 126-98-7 ------------------------------------------------------------------------------------------------------------------------------------ FINAL#1 2 YEAR CHRONIC RATS REASONS FOR REMOVAL: ALL REMOVAL DATE RANGE: ALL TREATMENT GROUPS: INCLUDE ALL NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11 LAB: Battelle Columbus METHACRYLONITRILE DATE: 02/24/00 EXPERIMENT: 88050 TEST: 05 TIME: 14:26:23 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE CONT: NO1-ES-55388 ROUTE: GAVAGE NTP C#: 88050B PATHOLOGIST: YARRINGTON, JOHN CAS: 126-98-7 METHACRYLONITRILE STATISTICAL ANALYSIS OF SURVIVAL DATA MALE RATS FIRST TERMINAL SACRIFICE AT 729 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== | DOSE = 0 MG/KG | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 25 CENSORED DEATHS 0 TERMINAL 25 | | | | UNCENSORED DEATHS | | 38 439 453 474 493 549 563 579 584 607 | | 617 629 639 657 668 674 674 691 697 701 | | 708 710 716 724 724 | | CENSORED DEATHS | | NONE | | | |--------------------------------------------------------------------------------| | DOSE = 3 MG/KG | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 | | | | UNCENSORED DEATHS | | 400 474 536 589 592 641 645 674 681 683 | | 696 697 697 697 710 716 | | CENSORED DEATHS | | NONE | | | |--------------------------------------------------------------------------------| | DOSE = 10 MG/KG | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 | | | | UNCENSORED DEATHS | | 276 464 464 474 480 617 642 662 687 688 | | 689 691 712 722 722 | | CENSORED DEATHS | | NONE | | | ================================================================================== METHACRYLONITRILE STATISTICAL ANALYSIS OF SURVIVAL DATA MALE RATS FIRST TERMINAL SACRIFICE AT 729 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== | DOSE = 30 MG/KG | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 1 TERMINAL 31 | | | | UNCENSORED DEATHS | | 351 456 466 530 533 603 618 624 645 657 | | 662 680 681 699 708 710 722 726 | | CENSORED DEATHS | | 530 | | | ================================================================================== METHACRYLONITRILE STATISTICAL ANALYSIS OF SURVIVAL DATA MALE RATS FIRST TERMINAL SACRIFICE AT 729 DAYS ================================================================================== | KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) | | | |--------------------------------------------------------------------------------| | DOSE TIME (DAYS) | | 90 180 270 365 425 485 545 605 665 729 (A) | | | |--------------------------------------------------------------------------------| | | | |0 MG/KG | 98.0 98.0 98.0 98.0 98.0 92.0 90.0 82.0 72.0 50.0 | | | | | | | |3 MG/KG | 100.0 100.0 100.0 100.0 98.0 96.0 94.0 90.0 86.0 68.0 | | | | | | | |10 MG/KG | 100.0 100.0 100.0 98.0 98.0 90.0 90.0 90.0 84.0 70.0 | | | | | | | |30 MG/KG | 100.0 100.0 100.0 98.0 98.0 94.0 90.0 87.9 77.7 63.4 | | | | | | | ================================================================================== ================================================================================== | SURVIVAL SUMMARY STATISTICS | | | | | |--------------------------------------------------------------------------------| | DOSE | | | | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG | | | |--------------------------------------------------------------------------------| |SURVIVAL AT END OF STUDY| 50.0% 68.0% 70.0% 63.4% | |(KAPLAN-MEIER) | | | | | |SIGNIFICANCE (B) | P=0.592N P=0.084N P=0.062N P=0.234N | |(LIFE TABLE) | | | | | |MEAN DAY OF | 600.3 633.0 599.3 615.1 | |NATURAL DEATHS (C) | (29.2) (23.1) (34.6) (25.1) | |(STANDARD ERROR) | | | | | |MEAN LIFE SPAN (D) | 664.7 698.3 690.1 684.0 | |(STANDARD ERROR) | (17.1) ( 9.7) (13.2) (12.2) | | | | ================================================================================== (A) FIRST TERMINAL SACRIFICE (B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT. SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS (COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N". (C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE (D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE) METHACRYLONITRILE STATISTICAL ANALYSIS OF SURVIVAL DATA FEMALE RATS FIRST TERMINAL SACRIFICE AT 731 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== | DOSE = 0 MG/KG | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 11 CENSORED DEATHS 1 TERMINAL 38 | | | | UNCENSORED DEATHS | | 438 514 589 616 641 679 690 716 718 719 | | 728 | | CENSORED DEATHS | | 674 | | | |--------------------------------------------------------------------------------| | DOSE = 3 MG/KG | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 1 TERMINAL 33 | | | | UNCENSORED DEATHS | | 441 505 527 540 575 599 609 617 679 679 | | 686 690 697 715 721 721 | | CENSORED DEATHS | | 328 | | | |--------------------------------------------------------------------------------| | DOSE = 10 MG/KG | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 1 TERMINAL 34 | | | | UNCENSORED DEATHS | | 256 325 434 470 470 562 603 651 661 686 | | 690 696 704 711 724 | | CENSORED DEATHS | | 508 | | | ================================================================================== METHACRYLONITRILE STATISTICAL ANALYSIS OF SURVIVAL DATA FEMALE RATS FIRST TERMINAL SACRIFICE AT 731 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== | DOSE = 30 MG/KG | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 0 TERMINAL 36 | | | | UNCENSORED DEATHS | | 246 499 500 527 549 553 589 595 641 682 | | 693 697 707 730 | | CENSORED DEATHS | | NONE | | | ================================================================================== METHACRYLONITRILE STATISTICAL ANALYSIS OF SURVIVAL DATA FEMALE RATS FIRST TERMINAL SACRIFICE AT 731 DAYS ================================================================================== | KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) | | | |--------------------------------------------------------------------------------| | DOSE TIME (DAYS) | | 90 180 270 365 425 485 545 605 665 731 (A) | | | |--------------------------------------------------------------------------------| | | | |0 MG/KG | 100.0 100.0 100.0 100.0 100.0 98.0 96.0 94.0 90.0 77.7 | | | | | | | |3 MG/KG | 100.0 100.0 100.0 100.0 100.0 98.0 91.8 87.8 83.7 67.3 | | | | | | | |10 MG/KG | 100.0 100.0 98.0 96.0 96.0 90.0 90.0 85.9 81.8 69.5 | | | | | | | |30 MG/KG | 100.0 100.0 98.0 98.0 98.0 98.0 92.0 84.0 82.0 72.0 | | | | | | | ================================================================================== ================================================================================== | SURVIVAL SUMMARY STATISTICS | | | | | |--------------------------------------------------------------------------------| | DOSE | | | | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG | | | |--------------------------------------------------------------------------------| |SURVIVAL AT END OF STUDY| 77.7% 67.3% 69.5% 72.0% | |(KAPLAN-MEIER) | | | | | |SIGNIFICANCE (B) | P=0.878 P=0.312 P=0.408 P=0.577 | |(LIFE TABLE) | | | | | |MEAN DAY OF | 640.7 625.1 576.2 586.3 | |NATURAL DEATHS (C) | (28.6) (21.8) (38.9) (33.8) | |(STANDARD ERROR) | | | | | |MEAN LIFE SPAN (D) | 710.0 689.0 680.1 690.5 | |(STANDARD ERROR) | ( 8.1) (12.3) (15.6) (13.1) | | | | ================================================================================== (A) FIRST TERMINAL SACRIFICE (B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT. SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS (COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N". (C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE (D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE) METHACRYLONITRILE KAPLAN-MEIER SURVIVAL CURVES 0 MG/KG = 1 3 MG/KG = 2 10 MG/KG = 3 30 MG/KG = 4 ------------------------------------------------------ SPECIES=RATS SEX=MALE ------------------------------------------------------- Plot of SURVIVAL*WEEK. Symbol is value of DOSE. | 100 + 1 1 3 4 2 | | 1 3 4 2 1 432 | 1 1442 2 95 + | 1 31 42 2 | 13 1 44 | 90 + 3 1 4 1 2 4 3 2 | | 1 1 4 3 22 | 1 1 44 32 3 2 P 85 + E | 11 4 4 3 223 R | 1 1 C | 44 E 80 + 1 1 4 4 2 2 N | T | 11 4 4 | 1 1 3 3 S 75 + U | 1 1 4 4 3 3 R | 1 1 2 2 V | 4 4 I 70 + 11 223 3 V | A | 424 2 L | 1 1 65 + | 11 4 4 | 11 | 60 + 11 | | | 11 55 + | 11 | | 50 + 1 1 | --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+-- 0 10 20 30 40 50 60 70 80 90 100 110 WEEK NOTE: 8 obs hidden. METHACRYLONITRILE KAPLAN-MEIER SURVIVAL CURVES 0 MG/KG = 1 3 MG/KG = 2 10 MG/KG = 3 30 MG/KG = 4 ----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------ Plot of SURVIVAL*WEEK. Symbol is value of DOSE. | | 100 + 1 43 1 | | 43 3 1 421 | 3 3 21 2 1 95 + | 3 3 4 2 2 1 1 P | 4 4 1 1 E | 2 2 R 90 + 3 3 2 2 1 1 C | E | 4 3 422 1 1 N | 2 2 3 1 1 T 85 + | 4 2 43 3 2 S | 4 4 U | 3 3 R 80 + 223 11 V | I | 223 1 1 V | 33 A 75 + 22 L | 2332 4 | 4 | 3 3 70 + 3 3 | | 2 2 | 65 + | --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+-- 0 10 20 30 40 50 60 70 80 90 100 110 WEEK NOTE: 17 obs hidden.