TDMS Study 88050-06 Pathology Tables
NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:32:57
FINAL#1, CORE STUDY MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 126-98-7
Lock Date: 06/26/98
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:32:57
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Natural Death 14 13 4 7
Moribund Sacrifice 1 2 3 3
Accidently Killed 15
Survivors
Natural Death 1
Terminal Sacrifice 34 35 43 25
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50) (50)
Periesophageal Tissue, Inflammation, Chronic
Active 1 (2%)
Gallbladder (50) (50) (50) (48)
Cyst 1 (2%)
Infiltration Cellular, Mononuclear Cell 1 (2%)
Intestine Small, Duodenum (49) (50) (50) (50)
Inflammation, Chronic Active 1 (2%)
Metaplasia, Squamous 1 (2%)
Epithelium, Ulcer 1 (2%)
Intestine Small, Jejunum (50) (50) (50) (50)
Ulcer 1 (2%)
Epithelium, Inflammation, Suppurative 1 (2%)
Peyer's Patch, Hyperplasia, Lymphoid 2 (4%)
Liver (50) (50) (49) (50)
Angiectasis 1 (2%) 1 (2%)
Basophilic Focus 1 (2%) 7 (14%) 2 (4%) 2 (4%)
Clear Cell Focus 3 (6%) 6 (12%) 6 (12%) 1 (2%)
Eosinophilic Focus 9 (18%) 3 (6%) 11 (22%) 3 (6%)
Hematopoietic Cell Proliferation 2 (4%) 2 (4%) 6 (12%) 2 (4%)
Hepatodiaphragmatic Nodule 1 (2%)
Infiltration Cellular, Mononuclear Cell 30 (60%) 36 (72%) 40 (82%) 30 (60%)
Inflammation, Chronic Active 32 (64%) 36 (72%) 41 (84%) 38 (76%)
Mineralization 1 (2%) 1 (2%)
Mixed Cell Focus 3 (6%) 1 (2%) 3 (6%)
Necrosis 3 (6%) 2 (4%) 2 (4%) 1 (2%)
Pigmentation 18 (36%) 12 (24%) 17 (35%) 7 (14%)
Tension Lipidosis 2 (4%) 3 (6%)
Hepatocyte, Vacuolization Cytoplasmic 7 (14%) 9 (18%) 3 (6%) 18 (36%)
Mesentery (16) (11) (15) (4)
Fibrosis 8 (50%) 7 (64%) 10 (67%) 2 (50%)
Hemorrhage 1 (9%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:32:57
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Chronic Active 5 (31%) 6 (55%) 8 (53%)
Mineralization 5 (31%) 7 (64%) 12 (80%) 1 (25%)
Pigmentation 1 (7%)
Thrombosis 1 (7%)
Fat, Necrosis 8 (50%) 7 (64%) 11 (73%) 3 (75%)
Oral Mucosa (3) (5) (2) (1)
Gingival, Foreign Body 2 (67%) 5 (100%) 1 (50%)
Gingival, Inflammation, Chronic Active 2 (67%) 5 (100%) 2 (100%)
Pharyngeal, Foreign Body 1 (33%)
Pancreas (50) (50) (50) (48)
Cyst 1 (2%)
Infiltration Cellular, Mononuclear Cell 2 (4%)
Acinus, Atrophy 1 (2%)
Acinus, Hyperplasia 1 (2%)
Salivary Glands (48) (50) (50) (49)
Infiltration Cellular, Mononuclear Cell 27 (56%) 29 (58%) 32 (64%) 27 (55%)
Inflammation, Chronic Active 2 (4%) 1 (2%)
Mineralization 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Diverticulum 1 (2%)
Hyperkeratosis 1 (2%)
Epithelium, Hyperplasia 3 (6%) 2 (4%) 1 (2%) 1 (2%)
Epithelium, Inflammation, Chronic Active 1 (2%) 2 (4%) 2 (4%) 1 (2%)
Epithelium, Ulcer 1 (2%) 1 (2%) 1 (2%)
Stomach, Glandular (50) (50) (50) (50)
Ectopic Tissue 1 (2%)
Mineralization 1 (2%) 1 (2%) 1 (2%)
Epithelium, Dysplasia 1 (2%)
Epithelium, Erosion 1 (2%)
Glands, Ectasia 16 (32%) 9 (18%) 10 (20%) 3 (6%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (49) (50) (50) (50)
Aorta, Mineralization 1 (2%)
Heart (50) (50) (50) (50)
Inflammation, Suppurative 1 (2%)
Mineralization 1 (2%)
Artery, Mineralization 1 (2%)
Valve, Inflammation, Chronic Active 1 (2%)
Valve, Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:32:57
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (50) (50) (50)
Accessory Adrenal Cortical Nodule 2 (4%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hypertrophy 1 (2%) 1 (2%)
Infiltration Cellular, Mononuclear Cell 1 (2%)
Capsule, Hyperplasia 48 (98%) 48 (96%) 50 (100%) 50 (100%)
Zona Reticularis, Hyperplasia 1 (2%)
Adrenal Medulla (49) (50) (50) (50)
Hyperplasia 1 (2%) 1 (2%)
Islets, Pancreatic (50) (50) (50) (49)
Hyperplasia 41 (82%) 37 (74%) 40 (80%) 33 (67%)
Pituitary Gland (49) (49) (49) (49)
Pars Distalis, Angiectasis 2 (4%) 3 (6%) 6 (12%) 2 (4%)
Pars Distalis, Cyst 1 (2%) 2 (4%) 2 (4%)
Pars Distalis, Hemorrhage 1 (2%)
Pars Distalis, Hyperplasia 9 (18%) 12 (24%) 10 (20%) 11 (22%)
Pars Distalis, Pigmentation 1 (2%)
Thyroid Gland (49) (50) (50) (50)
Ectopic Thymus 1 (2%)
Infiltration Cellular, Mononuclear Cell 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
C-Cell, Hyperplasia 1 (2%)
Follicle, Cyst 5 (10%) 3 (6%) 3 (6%) 4 (8%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (50) (50) (49)
Infiltration Cellular, Mononuclear Cell 4 (8%) 2 (4%) 3 (6%) 1 (2%)
Inflammation, Chronic Active 2 (4%) 1 (2%) 1 (2%)
Pigmentation 1 (2%)
Duct, Cyst 2 (4%) 2 (4%)
Ovary (50) (50) (50) (49)
Angiectasis 1 (2%)
Cyst 17 (34%) 14 (28%) 18 (36%) 10 (20%)
Hemorrhage 1 (2%) 4 (8%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Mineralization 2 (4%) 3 (6%) 2 (4%) 1 (2%)
Pigmentation 7 (14%) 16 (32%) 11 (22%) 6 (12%)
Thrombosis 1 (2%) 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:32:57
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Uterus (50) (50) (50) (50)
Angiectasis 1 (2%)
Hemorrhage 1 (2%)
Hydrometra 23 (46%) 28 (56%) 31 (62%) 20 (40%)
Inflammation, Chronic Active 1 (2%)
Inflammation, Suppurative 1 (2%)
Pigmentation 1 (2%)
Thrombosis 1 (2%)
Endometrium, Hyperplasia 1 (2%)
Endometrium, Hyperplasia, Cystic 27 (54%) 24 (48%) 24 (48%) 32 (64%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hyperplasia 2 (4%) 2 (4%) 4 (8%) 1 (2%)
Myelofibrosis 2 (4%) 3 (6%)
Lymph Node (9) (6) (8) (5)
Lumbar, Ectasia 1 (17%) 1 (20%)
Lumbar, Hyperplasia, Lymphoid 1 (13%)
Mediastinal, Hyperplasia, Lymphoid 1 (11%) 2 (25%)
Mediastinal, Infiltration Cellular,
Histiocyte 1 (11%)
Mediastinal, Inflammation 1 (20%)
Pancreatic, Fibrosis 1 (11%)
Pancreatic, Hyperplasia, Lymphoid 1 (11%)
Pancreatic, Pigmentation 1 (11%)
Lymph Node, Mandibular (48) (49) (46) (47)
Hyperplasia, Lymphoid 5 (10%) 4 (8%) 3 (7%) 1 (2%)
Infiltration Cellular, Plasma Cell 1 (2%)
Pigmentation 3 (6%) 16 (33%) 9 (20%) 4 (9%)
Lymph Node, Mesenteric (47) (48) (47) (46)
Ectasia 2 (4%)
Hemorrhage 2 (4%) 1 (2%)
Hyperplasia, Lymphoid 2 (4%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Pigmentation 1 (2%)
Spleen (50) (50) (49) (49)
Hematopoietic Cell Proliferation 18 (36%) 22 (44%) 15 (31%) 10 (20%)
Hyperplasia, Lymphoid 1 (2%) 3 (6%) 1 (2%)
Mineralization 1 (2%)
Necrosis 1 (2%)
Pigmentation 1 (2%)
Thymus (47) (43) (46) (48)
Cyst 20 (43%) 17 (40%) 23 (50%) 19 (40%)
Ectopic Parathyroid Gland 1 (2%) 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:32:57
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Thymocyte, Necrosis 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (50) (49) (49)
Hyperplasia, Cystic 3 (6%) 1 (2%)
Skin (50) (50) (50) (50)
Inflammation, Chronic Active 1 (2%)
Epidermis, Ulcer 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Osteosclerosis 1 (2%)
Skeletal Muscle (4) (1) (2)
Infiltration Cellular, Mononuclear Cell 1 (25%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Hemorrhage 1 (2%)
Infiltration Cellular, Mononuclear Cell 2 (4%)
Inflammation, Chronic Active 1 (2%)
Meninges, Hemorrhage 1 (2%)
Peripheral Nerve (1) (1)
Sciatic, Axon, Degeneration 1 (100%)
Spinal Cord (1) (2)
Demyelination 1 (100%) 1 (50%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Hemorrhage 1 (2%)
Inflammation, Chronic Active 2 (4%) 1 (2%) 3 (6%) 1 (2%)
Mineralization 5 (10%) 1 (2%) 2 (4%) 2 (4%)
Necrosis 1 (2%)
Pigmentation 1 (2%)
Thrombosis 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Alveolus, Infiltration Cellular, Histiocyte 1 (2%) 2 (4%)
Artery, Mediastinum, Mineralization 1 (2%)
Mediastinum, Mineralization 1 (2%)
Nose (50) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:32:57
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (1) (4)
Atrophy 1 (50%) 1 (100%) 1 (25%)
Anterior Chamber, Infiltration Cellular,
Polymorphonuclear 1 (25%)
Cornea, Inflammation, Chronic Active 1 (25%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (49) (50)
Accumulation, Hyaline Droplet 2 (4%) 1 (2%)
Hydronephrosis 1 (2%)
Infarct, Multiple 1 (2%)
Infiltration Cellular, Mononuclear Cell 35 (70%) 42 (84%) 44 (90%) 35 (70%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Mineralization 5 (10%) 5 (10%) 5 (10%) 6 (12%)
Nephropathy 15 (30%) 19 (38%) 22 (45%) 9 (18%)
Pigmentation 1 (2%)
Capsule, Mineralization 1 (2%)
Cortex, Cyst 2 (4%) 3 (6%) 1 (2%) 1 (2%)
Papilla, Inflammation, Acute 1 (2%)
Renal Tubule, Casts Protein 1 (2%)
Urinary Bladder (50) (50) (50) (50)
Infiltration Cellular, Mononuclear Cell 28 (56%) 31 (62%) 29 (58%) 22 (44%)
Inflammation, Chronic Active 1 (2%)
Pigmentation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:32:57
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Natural Death 9 5 4 3
Moribund Sacrifice 5 2 3
Dosing Accident 1
Accidently Killed 24
Survivors
Terminal Sacrifice 34 43 41 22
Natural Death 1 2
Missing 1
Animals Examined Microscopically 49 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (49) (50) (50) (50)
Inflammation, Chronic Active 1 (2%)
Periesophageal Tissue, Inflammation, Chronic
Active 1 (2%)
Intestine Small, Duodenum (49) (49) (50) (50)
Ectasia 1 (2%)
Hyperplasia 3 (6%) 1 (2%) 1 (2%)
Intestine Small, Jejunum (49) (50) (50) (50)
Inflammation, Chronic Active 1 (2%)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Intestine Small, Ileum (49) (50) (50) (49)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Liver (49) (50) (50) (50)
Angiectasis 1 (2%) 1 (2%)
Basophilic Focus 4 (8%) 6 (12%) 2 (4%)
Clear Cell Focus 7 (14%) 10 (20%) 10 (20%) 4 (8%)
Eosinophilic Focus 16 (33%) 10 (20%) 12 (24%) 3 (6%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 3 (6%) 1 (2%)
Hepatodiaphragmatic Nodule 1 (2%)
Infiltration Cellular, Mast Cell 1 (2%)
Infiltration Cellular, Mononuclear Cell 9 (18%) 11 (22%) 7 (14%) 6 (12%)
Inflammation, Chronic Active 22 (45%) 21 (42%) 19 (38%) 21 (42%)
Inflammation, Granulomatous 1 (2%)
Malformation 1 (2%)
Mineralization 1 (2%)
Mixed Cell Focus 11 (22%) 11 (22%) 2 (4%)
Necrosis 6 (12%) 5 (10%) 1 (2%)
Pigmentation 3 (6%) 2 (4%) 3 (6%)
Tension Lipidosis 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:32:57
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Bile Duct, Cyst 1 (2%) 1 (2%)
Bile Duct, Hyperplasia 1 (2%)
Hepatocyte, Vacuolization Cytoplasmic 6 (12%) 10 (20%) 9 (18%) 16 (32%)
Hepatocyte, Portal, Hypertrophy 1 (2%)
Hepatocyte, Centrilobular, Degeneration 1 (2%)
Mesentery (3) (6) (6) (1)
Fibrosis 1 (33%) 1 (17%)
Inflammation, Chronic Active 1 (33%) 1 (17%) 1 (17%) 1 (100%)
Inflammation, Granulomatous 2 (33%)
Mineralization 1 (17%) 1 (17%)
Thrombosis 1 (33%)
Fat, Necrosis 1 (33%) 2 (33%) 1 (17%)
Oral Mucosa (31) (30) (27) (10)
Gingival, Foreign Body 27 (87%) 29 (97%) 26 (96%) 10 (100%)
Gingival, Inflammation, Acute 9 (29%) 3 (10%) 10 (37%) 6 (60%)
Gingival, Inflammation, Chronic 1 (3%)
Gingival, Inflammation, Chronic Active 19 (61%) 26 (87%) 16 (59%) 2 (20%)
Pancreas (49) (50) (50) (50)
Infiltration Cellular, Mononuclear Cell 1 (2%) 1 (2%) 1 (2%)
Artery, Mineralization 1 (2%)
Salivary Glands (49) (50) (50) (50)
Granuloma 1 (2%)
Infiltration Cellular, Mononuclear Cell 22 (45%) 35 (70%) 36 (72%) 29 (58%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%) 1 (2%) 1 (2%)
Stomach, Forestomach (49) (50) (50) (50)
Cyst, Squamous 1 (2%)
Epithelium, Hyperplasia 2 (4%) 3 (6%) 1 (2%) 1 (2%)
Epithelium, Inflammation, Chronic Active 2 (4%) 1 (2%) 2 (4%)
Epithelium, Ulcer 1 (2%) 1 (2%)
Stomach, Glandular (49) (50) (50) (50)
Hyperplasia 1 (2%)
Mineralization 1 (2%) 2 (4%)
Ulcer 1 (2%)
Epithelium, Erosion 1 (2%)
Epithelium, Hyperplasia 1 (2%) 1 (2%)
Epithelium, Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%)
Glands, Ectasia 17 (35%) 10 (20%) 20 (40%) 5 (10%)
Serosa, Inflammation, Granulomatous 1 (2%)
Tooth (6) (1) (2)
Malformation 6 (100%) 1 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:32:57
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (48) (50) (50) (50)
Inflammation, Chronic Active 2 (4%) 1 (2%) 1 (2%)
Mineralization 2 (4%) 1 (2%) 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (50) (50) (50)
Degeneration, Fatty 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 14 (29%) 12 (24%) 16 (32%) 7 (14%)
Hypertrophy 26 (53%) 34 (68%) 28 (56%) 15 (30%)
Inflammation, Suppurative 1 (2%)
Metaplasia, Osseous 1 (2%)
Capsule, Hyperplasia 41 (84%) 41 (82%) 40 (80%) 45 (90%)
Adrenal Medulla (49) (50) (50) (50)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 1 (2%)
Islets, Pancreatic (49) (50) (50) (50)
Hyperplasia 47 (96%) 43 (86%) 48 (96%) 46 (92%)
Parathyroid Gland (42) (35) (39) (38)
Cyst 1 (2%) 2 (6%) 1 (3%) 1 (3%)
Pituitary Gland (48) (49) (49) (46)
Atypia Cellular 1 (2%)
Pars Distalis, Cyst 1 (2%) 2 (4%) 5 (10%) 3 (7%)
Pars Distalis, Hyperplasia 2 (4%) 2 (4%)
Thyroid Gland (49) (50) (50) (50)
Follicle, Cyst 2 (4%) 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (1) (2)
Inflammation, Suppurative 1 (100%)
Epididymis (49) (50) (50) (50)
Atrophy 1 (2%)
Granuloma Sperm 2 (4%) 1 (2%)
Infiltration Cellular, Mononuclear Cell 17 (35%) 26 (52%) 30 (60%) 21 (42%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%)
Mineralization 2 (4%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:32:57
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Penis (1)
Hemorrhage 1 (100%)
Preputial Gland (49) (50) (50) (49)
Atrophy 1 (2%)
Infiltration Cellular, Mononuclear Cell 21 (43%) 25 (50%) 27 (54%) 26 (53%)
Inflammation, Chronic Active 13 (27%) 6 (12%) 7 (14%) 3 (6%)
Duct, Cyst 18 (37%) 20 (40%) 18 (36%) 16 (33%)
Prostate (49) (50) (50) (50)
Atrophy 1 (2%)
Infiltration Cellular, Mononuclear Cell 25 (51%) 31 (62%) 34 (68%) 32 (64%)
Inflammation, Suppurative 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%)
Seminal Vesicle (49) (50) (50) (50)
Atrophy 1 (2%)
Dilatation 1 (2%)
Infiltration Cellular, Mononuclear Cell 2 (4%) 2 (4%)
Testes (49) (50) (50) (50)
Atrophy 1 (2%)
Inflammation, Chronic Active 1 (2%)
Mineralization 2 (4%) 2 (4%) 1 (2%)
Germinal Epithelium, Atrophy 1 (2%) 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (50) (50) (50)
Hyperplasia 4 (8%)
Lymph Node (3) (5) (3) (1)
Inguinal, Hyperplasia, Plasma Cell 1 (20%)
Lumbar, Hyperplasia, Plasma Cell 1 (20%)
Mediastinal, Hyperplasia, Plasma Cell 1 (20%)
Pancreatic, Hyperplasia, Lymphoid 1 (20%)
Renal, Hyperplasia, Plasma Cell 1 (20%)
Renal, Inflammation, Suppurative 1 (20%)
Lymph Node, Mandibular (46) (48) (50) (47)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Hyperplasia, Plasma Cell 1 (2%) 1 (2%)
Infiltration Cellular, Polymorphonuclear 1 (2%)
Lymph Node, Mesenteric (46) (43) (49) (47)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%) 1 (2%)
Hyperplasia, Plasma Cell 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Inflammation, Granulomatous 1 (2%)
Inflammation, Suppurative 1 (2%)
Spleen (49) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:32:57
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hematopoietic Cell Proliferation 12 (24%) 13 (26%) 14 (28%) 4 (8%)
Hyperplasia, Lymphoid 1 (2%) 4 (8%) 1 (2%)
Thymus (40) (48) (46) (49)
Atypia Cellular 1 (2%)
Cyst 16 (40%) 19 (40%) 18 (39%) 17 (35%)
Ectopic Parathyroid Gland 3 (8%) 1 (2%) 3 (7%) 1 (2%)
Ectopic Thyroid 1 (3%)
Mineralization 1 (2%)
Thymocyte, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (49) (50) (50) (50)
Infiltration Cellular, Mononuclear Cell 1 (2%)
Inflammation, Chronic Active 2 (4%) 3 (6%)
Epidermis, Hyperkeratosis 1 (2%)
Epidermis, Hyperplasia 2 (4%) 2 (4%)
Epidermis, Ulcer 2 (4%) 2 (4%)
Epidermis, Pinna, Hyperplasia 1 (2%)
Epidermis, Pinna, Ulcer 1 (2%)
Pinna, Inflammation, Chronic Active 1 (2%)
Subcutaneous Tissue, Fibrosis 1 (2%)
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Lung (49) (50) (50) (50)
Hemorrhage 1 (2%) 1 (2%)
Infiltration Cellular, Mononuclear Cell 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 2 (4%) 2 (4%) 4 (8%)
Mineralization 3 (6%) 1 (2%) 2 (4%)
Thrombosis 3 (6%) 2 (4%) 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia 3 (6%) 6 (12%) 5 (10%) 4 (8%)
Alveolus, Infiltration Cellular, Histiocyte 4 (8%) 8 (16%) 3 (6%) 3 (6%)
Bronchiole, Foreign Body 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:32:57
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B6C3F1 MICE MALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG
MG/KG
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RESPIRATORY SYSTEM - CONT
Mediastinum, Inflammation, Chronic Active 1 (2%)
Mediastinum, Inflammation, Suppurative 1 (2%)
Pleura, Inflammation, Chronic Active 1 (2%)
Nose (49) (50) (50) (50)
Foreign Body 3 (6%) 3 (6%) 4 (8%) 1 (2%)
Inflammation, Chronic Active 2 (4%) 3 (6%)
Nasolacrimal Duct, Inflammation, Suppurative 4 (8%) 1 (2%)
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SPECIAL SENSES SYSTEM
Eye (1) (1) (1)
Cornea, Inflammation, Chronic Active 1 (100%)
Cornea, Inflammation, Suppurative 1 (100%)
Cornea, Metaplasia, Squamous 1 (100%)
Harderian Gland (3) (2) (7) (1)
Infiltration Cellular, Mononuclear Cell 1 (33%)
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URINARY SYSTEM
Kidney (49) (50) (50) (50)
Infarct 2 (4%) 2 (4%) 1 (2%)
Infiltration Cellular, Mononuclear Cell 27 (55%) 37 (74%) 39 (78%) 22 (44%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Metaplasia, Osseous 2 (4%) 1 (2%)
Mineralization 43 (88%) 49 (98%) 47 (94%) 36 (72%)
Nephropathy 43 (88%) 48 (96%) 47 (94%) 39 (78%)
Artery, Inflammation, Chronic Active 1 (2%)
Cortex, Cyst 11 (22%) 12 (24%) 8 (16%) 9 (18%)
Renal Tubule, Hyperplasia 9 (18%) 8 (16%) 9 (18%) 2 (4%)
Renal Tubule, Necrosis 1 (2%)
Urinary Bladder (49) (50) (50) (50)
Hemorrhage 1 (2%)
Infiltration Cellular, Mononuclear Cell 12 (24%) 17 (34%) 9 (18%) 10 (20%)
Inflammation, Suppurative 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
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