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TDMS Study 88050-06 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                                     METHACRYLONITRILE                                   DATE: 10/19/99       
EXPERIMENT: 88050 TEST: 06                                                                                     TIME: 12:44:54       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-55388                              ROUTE: GAVAGE                                                  NTP C#: 88050B       
PATHOLOGIST: TOFT, JOHN                                                                                        CAS: 126-98-7        
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                      CORE STUDY MICE FINAL#1                                                       
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08
LAB: Battelle Columbus                                     METHACRYLONITRILE                                   DATE: 10/19/99

EXPERIMENT: 88050 TEST: 06                                                                                     TIME: 12:44:54
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-55388                              ROUTE: GAVAGE                                                  NTP C#: 88050B
PATHOLOGIST: TOFT, JOHN                                                                                        CAS: 126-98-7

Mice(B6C3F1)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.
                                                 ---------------
                                                 Adrenal Cortex
                                                 Adrenal Medulla
                                                 Bone Marrow
                                                 Brain
                                                 Islets, Pancreatic
                                                 Kidney
                                                 Liver
                                                 Lung
                                                 Ovary
                                                 Pancreas
                                                 Pituitary Gland
                                                 Prostate
                                                 Spleen
                                                 Testes
                                                 Thyroid Gland
                                                 Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08   
LAB: Battelle Columbus                                     METHACRYLONITRILE                                   DATE: 10/19/99     
EXPERIMENT: 88050 TEST: 06                                                                                     TIME: 12:44:54     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                      
CONT: NO1-ES-55388                              ROUTE: GAVAGE                                                  NTP C#: 88050B     
PATHOLOGIST: TOFT, JOHN                                                                                        CAS: 126-98-7      



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF                METHACRYLONITRILE
===============================================================

Male Mice
------------
Organ                                 Morphology
-----                                 ----------
Adrenal Cortex                         Adenoma
Liver                                  Hepatocellular Adenoma
                                       Hepatocellular Carcinoma
                                       Hepatocellular Carcinoma or Hepatoblastoma
                                       Hepatocellular Carcinoma or Hepatocellular Adenoma
                                       Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung                                   Alveolar/Bronchiolar Adenoma
All Organs                             Benign Tumors
                                       Malignant Tumors
                                       Malignant and Benign Tumors
===============================================================
Female Mice
------------
Organ                                  Morphology
-----                                  ----------
Intestine Large: Cecum                 Leiomyoma
Lung                                   Alveolar/Bronchiolar Adenoma
Mammary Gland                          Carcinoma
All Organs                             Hemangiosarcoma or Hemangioma
                                       Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated Cell Type
                                       Benign Tumors
                                       Malignant and Benign Tumors
===============================================================
       Date:  10/19/99                           EXPERIMENT: 88050 TEST: 06                                            Page 1
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)        -                 METHACRYLONITRILE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/49 (10%)   4/50 (8%)    4/50 (8%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     11.1%        8.4%         8.5%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     5/35 (14%)   3/43 (7%)    4/43 (9%)    0/22 (0%)   |0/34 (0%)    0/35 (0%)    0/43 (0%)    0/25 (0%)    |
|FIRST INCIDENCE    |     729 (T)      644          729 (T)      ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.069N     P=0.386N     P=0.372N     P=0.086N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.083N     P=0.460N     P=0.474N     P=0.078N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.058N     P=0.472N     P=0.482N     P=0.054N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.111N     P=0.442N     P=0.456N     P=0.105N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.078N     P=0.455N     P=0.372N     (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.028N*    P=0.487N     P=0.487N     P=0.027N*   |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    5/50 (10%)   1/50 (2%)   |2/50 (4%)    2/50 (4%)    2/50 (4%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     6.7%         4.2%         10.7%        3.2%        |4.4%         4.6%         4.2%         5.7%         |
|TERMINAL (d)       |     3/35 (9%)    2/43 (5%)    5/43 (12%)   1/22 (5%)   |2/35 (6%)    1/35 (3%)    1/43 (2%)    2/25 (8%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |730 (T)      638          589          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.530N     P=0.406N     P=0.473      P=0.482N    |P=0.473      P=0.689      P=0.635N     P=0.569      |
|POLY 3             |     P=0.534N     P=0.474N     P=0.380      P=0.446N    |P=0.493      P=0.679      P=0.671N     P=0.596      |
|POLY 1.5           |     P=0.454N     P=0.481N     P=0.372      P=0.388N    |P=0.527      P=0.682      P=0.680N     P=0.632      |
|POLY 6             |     P=0.512      P=0.463N     P=0.396      P=0.499N    |P=0.468      P=0.684      P=0.658N     P=0.567      |
|LOGISTIC REGRESSION|     P=0.530N     P=0.406N     P=0.473      P=0.482N    |P=0.532      P=0.682      P=0.676      P=0.569      |
|COCH-ARM / FISHERS |     P=0.319N     P=0.500N     P=0.357      P=0.309N    |P=0.596      P=0.691N     P=0.691N     P=0.691N     |
|=================================================================================================================================|
       Date:  10/19/99                           EXPERIMENT: 88050 TEST: 06                                            Page 2
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 METHACRYLONITRILE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         4.2%         0.0%        |4.4%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/35 (0%)    0/43 (0%)    1/43 (2%)    0/22 (0%)   |2/35 (6%)    0/35 (0%)    0/43 (0%)    0/25 (0%)    |
|FIRST INCIDENCE    |     ---          ---          502          ---         |730 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.490      (e)          P=0.262      (e)         |P=0.124N     P=0.238N     P=0.194N     P=0.315N     |
|POLY 3             |     P=0.350      (e)          P=0.250      (e)         |P=0.094N     P=0.248N     P=0.226N     P=0.299N     |
|POLY 1.5           |     P=0.448      (e)          P=0.246      (e)         |P=0.102N     P=0.246N     P=0.230N     P=0.276N     |
|POLY 6             |     P=0.285      (e)          P=0.258      (e)         |P=0.086N     P=0.247N     P=0.219N     P=0.319N     |
|LOGISTIC REGRESSION|     P=0.679      (e)          P=0.187      (e)         |P=0.124N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.595      (e)          P=0.247      (e)         |P=0.115N     P=0.247N     P=0.247N     P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    7/50 (14%)   1/50 (2%)   |4/50 (8%)    2/50 (4%)    2/50 (4%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     6.7%         4.2%         14.7%        3.2%        |8.9%         4.6%         4.2%         5.7%         |
|TERMINAL (d)       |     3/35 (9%)    2/43 (5%)    6/43 (14%)   1/22 (5%)   |4/35 (11%)   1/35 (3%)    1/43 (2%)    2/25 (8%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      502          729 (T)     |730 (T)      638          589          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.558      P=0.406N     P=0.244      P=0.482N    |P=0.411N     P=0.341N     P=0.262N     P=0.500N     |
|POLY 3             |     P=0.464      P=0.474N     P=0.181      P=0.446N    |P=0.344N     P=0.356N     P=0.309N     P=0.462N     |
|POLY 1.5           |     P=0.543N     P=0.481N     P=0.173      P=0.388N    |P=0.329N     P=0.353N     P=0.321N     P=0.417N     |
|POLY 6             |     P=0.368      P=0.463N     P=0.196      P=0.499N    |P=0.349N     P=0.350N     P=0.293N     P=0.500N     |
|LOGISTIC REGRESSION|     P=0.575N     P=0.406N     P=0.164      P=0.482N    |P=0.370N     P=0.357N     P=0.338N     P=0.500N     |
|COCH-ARM / FISHERS |     P=0.367N     P=0.500N     P=0.159      P=0.309N    |P=0.292N     P=0.339N     P=0.339N     P=0.339N     |
|=================================================================================================================================|
       Date:  10/19/99                           EXPERIMENT: 88050 TEST: 06                                            Page 3
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 METHACRYLONITRILE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large: Cecum                                                                                                           |
|     Leiomyoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |3/50 (6%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |6.6%         2.3%         0.0%         0.0%         |
|TERMINAL (d)       |     0/35 (0%)    0/43 (0%)    0/43 (0%)    0/22 (0%)   |3/35 (9%)    1/35 (3%)    0/43 (0%)    0/25 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |730 (T)      730 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.050N     P=0.305N     P=0.087N     P=0.186N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.040N*    P=0.323N     P=0.110N     P=0.172N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.042N*    P=0.319N     P=0.113N     P=0.152N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.038N*    P=0.320N     P=0.105N     P=0.191N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.050N     P=0.305N     (e)          (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.044N*    P=0.309N     P=0.121N     P=0.121N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small: Duodenum                                                                                                        |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    2/50 (4%)    1/50 (2%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.5%         0.0%         4.3%         3.2%        |2.2%         2.3%         0.0%         0.0%         |
|TERMINAL (d)       |     2/35 (6%)    0/43 (0%)    2/43 (5%)    1/22 (5%)   |1/35 (3%)    1/35 (3%)    0/43 (0%)    0/25 (0%)    |
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      729 (T)     |730 (T)      730 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.582      P=0.194N     P=0.619N     P=0.660N    |P=0.264N     P=0.762      P=0.459N     P=0.567N     |
|POLY 3             |     P=0.560      P=0.225N     P=0.679N     P=0.623N    |P=0.231N     P=0.750      P=0.490N     P=0.551N     |
|POLY 1.5           |     P=0.591N     P=0.228N     P=0.684N     P=0.576N    |P=0.236N     P=0.752      P=0.494N     P=0.533N     |
|POLY 6             |     P=0.529      P=0.219N     P=0.668N     P=0.664N    |P=0.223N     P=0.751      P=0.484N     P=0.565N     |
|LOGISTIC REGRESSION|     P=0.582      (e)          P=0.619N     P=0.660N    |P=0.264N     P=0.762      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.531N     P=0.247N     P=0.691N     P=0.500N    |P=0.236N     P=0.753N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
       Date:  10/19/99                           EXPERIMENT: 88050 TEST: 06                                            Page 4
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 METHACRYLONITRILE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small: Jejunum                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    2/50 (4%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.2%         2.1%         4.3%         6.3%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/35 (3%)    1/43 (2%)    2/43 (5%)    0/22 (0%)   |0/35 (0%)    0/35 (0%)    0/43 (0%)    0/25 (0%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      481         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.204      P=0.715N     P=0.572      P=0.396     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.214      P=0.748N     P=0.515      P=0.384     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.255      P=0.751N     P=0.510      P=0.428     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.192      P=0.742N     P=0.525      P=0.347     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.296      P=0.715N     P=0.572      P=0.503     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.337      P=0.753N     P=0.500      P=0.500     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small: Site Unspecified                                                                                                |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    2/50 (4%)    1/50 (2%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.5%         0.0%         4.3%         3.2%        |2.2%         2.3%         0.0%         0.0%         |
|TERMINAL (d)       |     2/35 (6%)    0/43 (0%)    2/43 (5%)    1/22 (5%)   |1/35 (3%)    1/35 (3%)    0/43 (0%)    0/25 (0%)    |
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      729 (T)     |730 (T)      730 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.582      P=0.194N     P=0.619N     P=0.660N    |P=0.264N     P=0.762      P=0.459N     P=0.567N     |
|POLY 3             |     P=0.560      P=0.225N     P=0.679N     P=0.623N    |P=0.231N     P=0.750      P=0.490N     P=0.551N     |
|POLY 1.5           |     P=0.591N     P=0.228N     P=0.684N     P=0.576N    |P=0.236N     P=0.752      P=0.494N     P=0.533N     |
|POLY 6             |     P=0.529      P=0.219N     P=0.668N     P=0.664N    |P=0.223N     P=0.751      P=0.484N     P=0.565N     |
|LOGISTIC REGRESSION|     P=0.582      (e)          P=0.619N     P=0.660N    |P=0.264N     P=0.762      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.531N     P=0.247N     P=0.691N     P=0.500N    |P=0.236N     P=0.753N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
       Date:  10/19/99                           EXPERIMENT: 88050 TEST: 06                                            Page 5
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 METHACRYLONITRILE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small: Site Unspecified                                                                                                |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    3/50 (6%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.2%         4.2%         6.4%         6.3%        |0.0%         0.0%         2.1%         0.0%         |
|TERMINAL (d)       |     1/35 (3%)    2/43 (5%)    2/43 (5%)    0/22 (0%)   |0/35 (0%)    0/35 (0%)    0/43 (0%)    0/25 (0%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      612          481         |---          ---          589          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.234      P=0.572      P=0.367      P=0.396     |P=0.656      (e)          P=0.504      (e)          |
|POLY 3             |     P=0.233      P=0.520      P=0.324      P=0.384     |P=0.562      (e)          P=0.512      (e)          |
|POLY 1.5           |     P=0.290      P=0.514      P=0.317      P=0.428     |P=0.614      (e)          P=0.507      (e)          |
|POLY 6             |     P=0.198      P=0.528      P=0.336      P=0.347     |P=0.513      (e)          P=0.519      (e)          |
|LOGISTIC REGRESSION|     P=0.376      P=0.572      P=0.304      P=0.503     |P=0.734N     (e)          P=0.365      (e)          |
|COCH-ARM / FISHERS |     P=0.404      P=0.500      P=0.309      P=0.500     |P=0.694      (e)          P=0.500      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small: Site Unspecified                                                                                                |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    5/50 (10%)   3/50 (6%)   |1/50 (2%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     6.7%         4.2%         10.6%        9.4%        |2.2%         2.3%         2.1%         0.0%         |
|TERMINAL (d)       |     3/35 (9%)    2/43 (5%)    4/43 (9%)    1/22 (5%)   |1/35 (3%)    1/35 (3%)    0/43 (0%)    0/25 (0%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      612          481         |730 (T)      730 (T)      589          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.251      P=0.406N     P=0.462      P=0.478     |P=0.374N     P=0.762      P=0.735N     P=0.567N     |
|POLY 3             |     P=0.269      P=0.474N     P=0.385      P=0.497     |P=0.354N     P=0.750      P=0.746N     P=0.551N     |
|POLY 1.5           |     P=0.339      P=0.481N     P=0.375      P=0.563     |P=0.341N     P=0.752      P=0.752N     P=0.533N     |
|POLY 6             |     P=0.225      P=0.463N     P=0.404      P=0.438     |P=0.361N     P=0.751      P=0.738N     P=0.565N     |
|LOGISTIC REGRESSION|     P=0.339      P=0.406N     P=0.375      P=0.529     |P=0.312N     P=0.762      P=0.719      (e)          |
|COCH-ARM / FISHERS |     P=0.481      P=0.500N     P=0.357      P=0.661N    |P=0.311N     P=0.753N     P=0.753N     P=0.500N     |
|=================================================================================================================================|
       Date:  10/19/99                           EXPERIMENT: 88050 TEST: 06                                            Page 6
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 METHACRYLONITRILE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/49 (4%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     4.4%         0.0%         2.1%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/35 (0%)    0/43 (0%)    1/43 (2%)    0/22 (0%)   |0/35 (0%)    0/35 (0%)    0/43 (0%)    0/25 (0%)    |
|FIRST INCIDENCE    |     677          ---          729 (T)      ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.255N     P=0.222N     P=0.452N     P=0.371N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.212N     P=0.226N     P=0.488N     P=0.330N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.206N     P=0.229N     P=0.491N     P=0.291N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.226N     P=0.222N     P=0.480N     P=0.367N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.205N     P=0.257N     P=0.494N     P=0.289N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.185N     P=0.242N     P=0.492N     P=0.242N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     17/49 (35%)  27/50 (54%)  24/50 (48%)  12/50 (24%) |9/50 (18%)   9/50 (18%)   12/49 (24%)  5/50 (10%)   |
|POLY-3 ADJUSTED (b)|     36.3%        54.7%        49.2%        34.7%       |19.8%        20.8%        25.5%        14.1%        |
|TERMINAL (d)       |     12/35 (34%)  22/43 (51%)  21/43 (49%)  7/22 (32%)  |7/35 (20%)   8/35 (23%)   12/43 (28%)  4/25 (16%)   |
|FIRST INCIDENCE    |     501          605          429          481         |653          638          730 (T)      480          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.512      P=0.168      P=0.318      P=0.518     |P=0.384N     P=0.599      P=0.507      P=0.411N     |
|POLY 3             |     P=0.442N     P=0.053      P=0.143      P=0.531N    |P=0.380N     P=0.559      P=0.341      P=0.355N     |
|POLY 1.5           |     P=0.253N     P=0.046 *    P=0.135      P=0.380N    |P=0.305N     P=0.569      P=0.322      P=0.292N     |
|POLY 6             |     P=0.448      P=0.064      P=0.159      P=0.517     |P=0.440N     P=0.563      P=0.367      P=0.411N     |
|LOGISTIC REGRESSION|     P=0.123N     P=0.030 *    P=0.119      P=0.296N    |P=0.386N     P=0.564      P=0.408      P=0.370N     |
|COCH-ARM / FISHERS |     P=0.051N     P=0.041 *    P=0.127      P=0.172N    |P=0.183N     P=0.602N     P=0.294      P=0.194N     |
|=================================================================================================================================|
       Date:  10/19/99                           EXPERIMENT: 88050 TEST: 06                                            Page 7
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 METHACRYLONITRILE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     13/49 (27%)  7/50 (14%)   7/50 (14%)   4/50 (8%)   |2/50 (4%)    2/50 (4%)    4/49 (8%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     27.5%        14.4%        14.9%        12.4%       |4.4%         4.7%         8.5%         2.9%         |
|TERMINAL (d)       |     6/35 (17%)   3/43 (7%)    6/43 (14%)   1/22 (5%)   |0/35 (0%)    2/35 (6%)    3/43 (7%)    1/25 (4%)    |
|FIRST INCIDENCE    |     501          625          694          481         |662          730 (T)      653          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.112N     P=0.074N     P=0.064N     P=0.161N    |P=0.565N     P=0.692N     P=0.412      P=0.621N     |
|POLY 3             |     P=0.063N     P=0.091N     P=0.106N     P=0.097N    |P=0.565N     P=0.674      P=0.356      P=0.591N     |
|POLY 1.5           |     P=0.040N*    P=0.093N     P=0.103N     P=0.049N*   |P=0.520N     P=0.679      P=0.345      P=0.559N     |
|POLY 6             |     P=0.087N     P=0.087N     P=0.105N     P=0.165N    |P=0.534      P=0.674      P=0.371      P=0.618N     |
|LOGISTIC REGRESSION|     P=0.010N*    P=0.155N     P=0.097N     P=0.019N*   |P=0.537N     P=0.682      P=0.309      P=0.587N     |
|COCH-ARM / FISHERS |     P=0.014N*    P=0.096N     P=0.096N     P=0.014N*   |P=0.433N     P=0.691N     P=0.329      P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatoblastoma                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     14/49 (29%)  7/50 (14%)   7/50 (14%)   4/50 (8%)   |2/50 (4%)    2/50 (4%)    4/49 (8%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     29.6%        14.4%        14.9%        12.4%       |4.4%         4.7%         8.5%         2.9%         |
|TERMINAL (d)       |     7/35 (20%)   3/43 (7%)    6/43 (14%)   1/22 (5%)   |0/35 (0%)    2/35 (6%)    3/43 (7%)    1/25 (4%)    |
|FIRST INCIDENCE    |     501          625          694          481         |662          730 (T)      653          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.079N     P=0.047N*    P=0.040N*    P=0.123N    |P=0.565N     P=0.692N     P=0.412      P=0.621N     |
|POLY 3             |     P=0.040N*    P=0.058N     P=0.069N     P=0.067N    |P=0.565N     P=0.674      P=0.356      P=0.591N     |
|POLY 1.5           |     P=0.025N*    P=0.060N     P=0.067N     P=0.031N*   |P=0.520N     P=0.679      P=0.345      P=0.559N     |
|POLY 6             |     P=0.056N     P=0.055N     P=0.069N     P=0.124N    |P=0.534      P=0.674      P=0.371      P=0.618N     |
|LOGISTIC REGRESSION|     P=0.006N**   P=0.104N     P=0.064N     P=0.013N*   |P=0.537N     P=0.682      P=0.309      P=0.587N     |
|COCH-ARM / FISHERS |     P=0.008N**   P=0.063N     P=0.063N     P=0.008N**  |P=0.433N     P=0.691N     P=0.329      P=0.500N     |
|=================================================================================================================================|
       Date:  10/19/99                           EXPERIMENT: 88050 TEST: 06                                            Page 8
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 METHACRYLONITRILE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     24/49 (49%)  29/50 (58%)  28/50 (56%)  15/50 (30%) |10/50 (20%)  11/50 (22%)  14/49 (29%)  6/50 (12%)   |
|POLY-3 ADJUSTED (b)|     50.7%        58.6%        57.2%        41.9%       |21.9%        25.4%        29.6%        16.9%        |
|TERMINAL (d)       |     16/35 (46%)  23/43 (54%)  24/43 (56%)  7/22 (32%)  |7/35 (20%)   10/35 (29%)  13/43 (30%)  5/25 (20%)   |
|FIRST INCIDENCE    |     501          605          429          481         |653          638          653          480          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.477N     P=0.539      P=0.538N     P=0.503N    |P=0.414N     P=0.494      P=0.431      P=0.454N     |
|POLY 3             |     P=0.256N     P=0.281      P=0.331      P=0.283N    |P=0.410N     P=0.444      P=0.269      P=0.392N     |
|POLY 1.5           |     P=0.117N     P=0.264      P=0.321      P=0.156N    |P=0.322N     P=0.458      P=0.251      P=0.319N     |
|POLY 6             |     P=0.410N     P=0.311      P=0.352      P=0.429N    |P=0.483N     P=0.443      P=0.294      P=0.458N     |
|LOGISTIC REGRESSION|     P=0.050N     P=0.205      P=0.298      P=0.118N    |P=0.400N     P=0.453      P=0.284      P=0.401N     |
|COCH-ARM / FISHERS |     P=0.014N*    P=0.243      P=0.309      P=0.042N*   |P=0.181N     P=0.500      P=0.224      P=0.207N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma,                                                                           |
|     or Hepatoblastoma                                                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     24/49 (49%)  29/50 (58%)  28/50 (56%)  15/50 (30%) |10/50 (20%)  11/50 (22%)  14/49 (29%)  6/50 (12%)   |
|POLY-3 ADJUSTED (b)|     50.7%        58.6%        57.2%        41.9%       |21.9%        25.4%        29.6%        16.9%        |
|TERMINAL (d)       |     16/35 (46%)  23/43 (54%)  24/43 (56%)  7/22 (32%)  |7/35 (20%)   10/35 (29%)  13/43 (30%)  5/25 (20%)   |
|FIRST INCIDENCE    |     501          605          429          481         |653          638          653          480          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.477N     P=0.539      P=0.538N     P=0.503N    |P=0.414N     P=0.494      P=0.431      P=0.454N     |
|POLY 3             |     P=0.256N     P=0.281      P=0.331      P=0.283N    |P=0.410N     P=0.444      P=0.269      P=0.392N     |
|POLY 1.5           |     P=0.117N     P=0.264      P=0.321      P=0.156N    |P=0.322N     P=0.458      P=0.251      P=0.319N     |
|POLY 6             |     P=0.410N     P=0.311      P=0.352      P=0.429N    |P=0.483N     P=0.443      P=0.294      P=0.458N     |
|LOGISTIC REGRESSION|     P=0.050N     P=0.205      P=0.298      P=0.118N    |P=0.400N     P=0.453      P=0.284      P=0.401N     |
|COCH-ARM / FISHERS |     P=0.014N*    P=0.243      P=0.309      P=0.042N*   |P=0.181N     P=0.500      P=0.224      P=0.207N     |
|=================================================================================================================================|
       Date:  10/19/99                           EXPERIMENT: 88050 TEST: 06                                            Page 9
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 METHACRYLONITRILE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocholangiocarcinoma                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.2%         4.2%         2.1%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/35 (0%)    1/43 (2%)    0/43 (0%)    0/22 (0%)   |0/35 (0%)    0/35 (0%)    0/43 (0%)    0/25 (0%)    |
|FIRST INCIDENCE    |     513          625          694          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.368N     P=0.536      P=0.750N     P=0.630N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.330N     P=0.518      P=0.754N     P=0.574N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.301N     P=0.513      P=0.756N     P=0.545N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.366N     P=0.526      P=0.748N     P=0.598N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.130N     P=0.315      P=0.716N     P=0.316N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.243N     P=0.508      P=0.747N     P=0.495N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/49 (4%)    11/50 (22%)  8/50 (16%)   5/50 (10%)  |6/50 (12%)   3/50 (6%)    1/50 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     4.5%         22.9%        16.9%        15.7%       |13.3%        7.0%         2.1%         5.7%         |
|TERMINAL (d)       |     2/35 (6%)    9/43 (21%)   7/43 (16%)   4/22 (18%)  |5/35 (14%)   3/35 (9%)    1/43 (2%)    1/25 (4%)    |
|FIRST INCIDENCE    |     729 (T)      629          612          481         |709          730 (T)      730 (T)      673          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.149      P=0.023 *    P=0.088      P=0.088     |P=0.127N     P=0.239N     P=0.033N*    P=0.267N     |
|POLY 3             |     P=0.165      P=0.010 *    P=0.054      P=0.104     |P=0.092N     P=0.267N     P=0.048N*    P=0.231N     |
|POLY 1.5           |     P=0.258      P=0.009 **   P=0.051      P=0.141     |P=0.089N     P=0.261N     P=0.051N     P=0.193N     |
|POLY 6             |     P=0.114      P=0.012 *    P=0.060      P=0.078     |P=0.091N     P=0.264N     P=0.044N*    P=0.264N     |
|LOGISTIC REGRESSION|     P=0.185      P=0.012 *    P=0.055      P=0.088     |P=0.134N     P=0.240N     P=0.038N*    P=0.267N     |
|COCH-ARM / FISHERS |     P=0.485      P=0.008 **   P=0.049 *    P=0.226     |P=0.079N     P=0.243N     P=0.056N     P=0.134N     |
|=================================================================================================================================|
       Date:  10/19/99                           EXPERIMENT: 88050 TEST: 06                                            Page 10
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 METHACRYLONITRILE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/49 (8%)    3/50 (6%)    1/50 (2%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    1/50 (2%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     8.9%         6.2%         2.1%         3.2%        |2.2%         0.0%         2.1%         8.5%         |
|TERMINAL (d)       |     4/35 (11%)   2/43 (5%)    1/43 (2%)    1/22 (5%)   |1/35 (3%)    0/35 (0%)    1/43 (2%)    1/25 (4%)    |
|FIRST INCIDENCE    |     729 (T)      563          729 (T)      729 (T)     |730 (T)      ---          730 (T)      641          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.172N     P=0.400N     P=0.123N     P=0.341N    |P=0.050      P=0.500N     P=0.715N     P=0.199      |
|POLY 3             |     P=0.128N     P=0.462N     P=0.166N     P=0.311N    |P=0.077      P=0.510N     P=0.749N     P=0.224      |
|POLY 1.5           |     P=0.118N     P=0.474N     P=0.170N     P=0.253N    |P=0.082      P=0.507N     P=0.753N     P=0.250      |
|POLY 6             |     P=0.136N     P=0.447N     P=0.158N     P=0.367N    |P=0.074      P=0.509N     P=0.742N     P=0.206      |
|LOGISTIC REGRESSION|     P=0.150N     P=0.501N     P=0.123N     P=0.341N    |P=0.062      (e)          P=0.715N     P=0.219      |
|COCH-ARM / FISHERS |     P=0.089N     P=0.489N     P=0.175N     P=0.175N    |P=0.097      P=0.500N     P=0.753N     P=0.309      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/49 (12%)   13/50 (26%)  9/50 (18%)   5/50 (10%)  |6/50 (12%)   3/50 (6%)    2/50 (4%)    5/50 (10%)   |
|POLY-3 ADJUSTED (b)|     13.4%        26.8%        19.1%        15.7%       |13.3%        7.0%         4.2%         14.1%        |
|TERMINAL (d)       |     6/35 (17%)   10/43 (23%)  8/43 (19%)   4/22 (18%)  |5/35 (14%)   3/35 (9%)    2/43 (5%)    2/25 (8%)    |
|FIRST INCIDENCE    |     729 (T)      563          612          481         |709          730 (T)      730 (T)      641          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.506      P=0.145      P=0.439      P=0.463     |P=0.470      P=0.239N     P=0.081N     P=0.524      |
|POLY 3             |     P=0.534      P=0.087      P=0.325      P=0.515     |P=0.547N     P=0.267N     P=0.117N     P=0.586      |
|POLY 1.5           |     P=0.424N     P=0.078      P=0.312      P=0.608     |P=0.537N     P=0.261N     P=0.124N     P=0.610N     |
|POLY 6             |     P=0.442      P=0.100      P=0.350      P=0.431     |P=0.547N     P=0.264N     P=0.109N     P=0.546      |
|LOGISTIC REGRESSION|     P=0.528N     P=0.075      P=0.334      P=0.442     |P=0.476      P=0.240N     P=0.093N     P=0.543      |
|COCH-ARM / FISHERS |     P=0.218N     P=0.068      P=0.303      P=0.486N    |P=0.500N     P=0.243N     P=0.134N     P=0.500N     |
|=================================================================================================================================|
       Date:  10/19/99                           EXPERIMENT: 88050 TEST: 06                                            Page 11
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 METHACRYLONITRILE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         5.7%         |
|TERMINAL (d)       |     0/35 (0%)    0/43 (0%)    0/43 (0%)    0/22 (0%)   |0/35 (0%)    0/35 (0%)    0/43 (0%)    1/25 (4%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          581          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.024 *    (e)          (e)          P=0.163      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.040 *    (e)          (e)          P=0.187      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.041 *    (e)          (e)          P=0.203      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.039 *    (e)          (e)          P=0.176      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.051      (e)          (e)          P=0.228      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.046 *    (e)          (e)          P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         2.3%         0.0%         5.7%         |
|TERMINAL (d)       |     0/35 (0%)    0/43 (0%)    0/43 (0%)    0/22 (0%)   |0/35 (0%)    1/35 (3%)    0/43 (0%)    1/25 (4%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          730 (T)      ---          581          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.086      P=0.500      (e)          P=0.163      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.116      P=0.490      (e)          P=0.187      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.122      P=0.493      (e)          P=0.203      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.114      P=0.491      (e)          P=0.176      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.129      P=0.500      (e)          P=0.228      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.140      P=0.500      (e)          P=0.247      |
|=================================================================================================================================|
       Date:  10/19/99                           EXPERIMENT: 88050 TEST: 06                                            Page 12
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 METHACRYLONITRILE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         2.3%         0.0%         5.7%         |
|TERMINAL (d)       |     0/35 (0%)    0/43 (0%)    0/43 (0%)    0/22 (0%)   |0/35 (0%)    1/35 (3%)    0/43 (0%)    1/25 (4%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          730 (T)      ---          581          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.086      P=0.500      (e)          P=0.163      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.116      P=0.490      (e)          P=0.187      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.122      P=0.493      (e)          P=0.203      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.114      P=0.491      (e)          P=0.176      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.129      P=0.500      (e)          P=0.228      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.140      P=0.500      (e)          P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cystadenoma                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |2/50 (4%)    1/50 (2%)    1/50 (2%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|                                                        |4.4%         2.3%         2.1%         2.9%         |
|TERMINAL (d)       |                                                        |2/35 (6%)    1/35 (3%)    1/43 (2%)    1/25 (4%)    |
|FIRST INCIDENCE    |                                                        |730 (T)      730 (T)      730 (T)      730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.499N     P=0.500N     P=0.428N     P=0.617N     |
|POLY 3             |                                                        |P=0.444N     P=0.517N     P=0.482N     P=0.595N     |
|POLY 1.5           |                                                        |P=0.438N     P=0.513N     P=0.489N     P=0.565N     |
|POLY 6             |                                                        |P=0.444N     P=0.515N     P=0.471N     P=0.618N     |
|LOGISTIC REGRESSION|                                                        |P=0.499N     P=0.500N     P=0.428N     P=0.617N     |
|COCH-ARM / FISHERS |                                                        |P=0.416N     P=0.500N     P=0.500N     P=0.508N     |
|=================================================================================================================================|
       Date:  10/19/99                           EXPERIMENT: 88050 TEST: 06                                            Page 13
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 METHACRYLONITRILE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Hemangioma                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|                                                        |4.4%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |                                                        |2/35 (6%)    0/35 (0%)    0/43 (0%)    0/25 (0%)    |
|FIRST INCIDENCE    |                                                        |730 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.124N     P=0.238N     P=0.194N     P=0.315N     |
|POLY 3             |                                                        |P=0.095N     P=0.248N     P=0.226N     P=0.304N     |
|POLY 1.5           |                                                        |P=0.103N     P=0.246N     P=0.230N     P=0.281N     |
|POLY 6             |                                                        |P=0.087N     P=0.247N     P=0.219N     P=0.322N     |
|LOGISTIC REGRESSION|                                                        |P=0.124N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |                                                        |P=0.116N     P=0.247N     P=0.247N     P=0.253N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/48 (0%)    0/49 (0%)    0/49 (0%)    0/46 (0%)   |2/49 (4%)    1/49 (2%)    2/49 (4%)    2/49 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |4.5%         2.3%         4.3%         5.8%         |
|TERMINAL (d)       |     0/35 (0%)    0/42 (0%)    0/42 (0%)    0/22 (0%)   |2/35 (6%)    1/35 (3%)    2/43 (5%)    1/25 (4%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |730 (T)      730 (T)      730 (T)      641          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.410      P=0.500N     P=0.619N     P=0.567      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.434      P=0.515N     P=0.674N     P=0.599      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.464      P=0.512N     P=0.682N     P=0.633      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.414      P=0.513N     P=0.664N     P=0.574      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.418      P=0.500N     P=0.619N     P=0.592      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.526      P=0.500N     P=0.691N     P=0.691N     |
|=================================================================================================================================|
       Date:  10/19/99                           EXPERIMENT: 88050 TEST: 06                                            Page 14
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 METHACRYLONITRILE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Intermedia                                                                                                 |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/48 (0%)    0/49 (0%)    0/49 (0%)    0/46 (0%)   |2/49 (4%)    0/49 (0%)    0/49 (0%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |4.5%         0.0%         0.0%         2.9%         |
|TERMINAL (d)       |     0/35 (0%)    0/42 (0%)    0/42 (0%)    0/22 (0%)   |2/35 (6%)    0/35 (0%)    0/43 (0%)    1/25 (4%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |730 (T)      ---          ---          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.533N     P=0.238N     P=0.194N     P=0.617N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.421N     P=0.247N     P=0.225N     P=0.589N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.439N     P=0.245N     P=0.230N     P=0.558N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.401N     P=0.246N     P=0.219N     P=0.613N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.533N     (e)          (e)          P=0.617N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.461N     P=0.247N     P=0.247N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        |
|     or Fibrous Histiocytoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    2/50 (4%)    5/50 (10%)   1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |4.4%         4.6%         10.2%        2.9%         |
|TERMINAL (d)       |     0/35 (0%)    0/43 (0%)    0/43 (0%)    0/22 (0%)   |1/35 (3%)    0/35 (0%)    1/43 (2%)    1/25 (4%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |671          521          589          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.571      P=0.677      P=0.268      P=0.614N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.528      P=0.683      P=0.250      P=0.590N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.559N     P=0.684      P=0.236      P=0.559N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.472      P=0.688      P=0.269      P=0.616N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.365N     P=0.648N     P=0.125      P=0.606N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.456N     P=0.691N     P=0.218      P=0.500N     |
|=================================================================================================================================|
       Date:  10/19/99                           EXPERIMENT: 88050 TEST: 06                                            Page 15
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 METHACRYLONITRILE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    1/50 (2%)    5/50 (10%)   1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |4.4%         2.3%         10.2%        2.9%         |
|TERMINAL (d)       |     0/35 (0%)    0/43 (0%)    0/43 (0%)    0/22 (0%)   |1/35 (3%)    0/35 (0%)    1/43 (2%)    1/25 (4%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |671          521          589          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.521      P=0.510N     P=0.268      P=0.614N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.477      P=0.513N     P=0.250      P=0.590N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.543      P=0.511N     P=0.236      P=0.559N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.421      P=0.511N     P=0.269      P=0.616N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.438N     P=0.449N     P=0.125      P=0.606N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.523N     P=0.500N     P=0.218      P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    2/50 (4%)    5/50 (10%)   1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |4.4%         4.6%         10.2%        2.9%         |
|TERMINAL (d)       |     0/35 (0%)    0/43 (0%)    0/43 (0%)    0/22 (0%)   |1/35 (3%)    0/35 (0%)    1/43 (2%)    1/25 (4%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |671          521          589          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.571      P=0.677      P=0.268      P=0.614N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.528      P=0.683      P=0.250      P=0.590N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.559N     P=0.684      P=0.236      P=0.559N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.472      P=0.688      P=0.269      P=0.616N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.365N     P=0.648N     P=0.125      P=0.606N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.456N     P=0.691N     P=0.218      P=0.500N     |
|=================================================================================================================================|
       Date:  10/19/99                           EXPERIMENT: 88050 TEST: 06                                            Page 16
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 METHACRYLONITRILE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Schwannoma Malignant                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |4.4%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/35 (0%)    0/43 (0%)    0/43 (0%)    0/22 (0%)   |1/35 (3%)    0/35 (0%)    0/43 (0%)    0/25 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |607          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.133N     P=0.252N     P=0.219N     P=0.326N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.093N     P=0.250N     P=0.228N     P=0.302N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.101N     P=0.247N     P=0.232N     P=0.278N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.085N     P=0.250N     P=0.223N     P=0.323N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.101N     P=0.222N     P=0.272N     P=0.238N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.115N     P=0.247N     P=0.247N     P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.2%         4.2%         2.1%         0.0%        |0.0%         0.0%         2.1%         0.0%         |
|TERMINAL (d)       |     0/35 (0%)    2/43 (5%)    1/43 (2%)    0/22 (0%)   |0/35 (0%)    0/35 (0%)    1/43 (2%)    0/25 (0%)    |
|FIRST INCIDENCE    |     513          729 (T)      729 (T)      ---         |---          ---          730 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.350N     P=0.552      P=0.740N     P=0.630N    |P=0.672      (e)          P=0.541      (e)          |
|POLY 3             |     P=0.329N     P=0.515      P=0.754N     P=0.574N    |P=0.563      (e)          P=0.510      (e)          |
|POLY 1.5           |     P=0.300N     P=0.511      P=0.756N     P=0.545N    |P=0.615      (e)          P=0.506      (e)          |
|POLY 6             |     P=0.364N     P=0.521      P=0.749N     P=0.599N    |P=0.515      (e)          P=0.516      (e)          |
|LOGISTIC REGRESSION|     P=0.229N     P=0.440      P=0.729      P=0.410N    |(e)          (e)          P=0.541      (e)          |
|COCH-ARM / FISHERS |     P=0.247N     P=0.500      P=0.753N     P=0.500N    |P=0.694      (e)          P=0.500      (e)          |
|=================================================================================================================================|
       Date:  10/19/99                           EXPERIMENT: 88050 TEST: 06                                            Page 17
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 METHACRYLONITRILE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/49 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.2%         0.0%         0.0%         0.0%        |0.0%         4.6%         0.0%         0.0%         |
|TERMINAL (d)       |     1/35 (3%)    0/43 (0%)    0/43 (0%)    0/22 (0%)   |0/35 (0%)    1/35 (3%)    0/43 (0%)    0/25 (0%)    |
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |---          644          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.344N     P=0.459N     P=0.459N     P=0.593N    |P=0.465N     P=0.235      (e)          (e)          |
|POLY 3             |     P=0.242N     P=0.488N     P=0.492N     P=0.571N    |P=0.431N     P=0.231      (e)          (e)          |
|POLY 1.5           |     P=0.271N     P=0.492N     P=0.494N     P=0.543N    |P=0.425N     P=0.234      (e)          (e)          |
|POLY 6             |     P=0.234N     P=0.484N     P=0.486N     P=0.595N    |P=0.430N     P=0.233      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.344N     (e)          (e)          (e)         |P=0.410N     P=0.242      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.303N     P=0.495N     P=0.495N     P=0.495N    |P=0.402N     P=0.253      (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    0/50 (0%)    1/50 (2%)    1/50 (2%)   |0/49 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.2%         0.0%         2.1%         3.1%        |0.0%         4.6%         2.1%         0.0%         |
|TERMINAL (d)       |     1/35 (3%)    0/43 (0%)    1/43 (2%)    0/22 (0%)   |0/35 (0%)    1/35 (3%)    1/43 (2%)    0/25 (0%)    |
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      481         |---          644          730 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.463      P=0.459N     P=0.715N     P=0.710     |P=0.539N     P=0.235      P=0.541      (e)          |
|POLY 3             |     P=0.431      P=0.488N     P=0.751N     P=0.677     |P=0.535N     P=0.231      P=0.514      (e)          |
|POLY 1.5           |     P=0.469      P=0.492N     P=0.754N     P=0.712     |P=0.510N     P=0.234      P=0.510      (e)          |
|POLY 6             |     P=0.412      P=0.484N     P=0.745N     P=0.645     |P=0.552N     P=0.233      P=0.519      (e)          |
|LOGISTIC REGRESSION|     P=0.648      (e)          P=0.715N     P=0.719N    |P=0.498N     P=0.242      P=0.541      (e)          |
|COCH-ARM / FISHERS |     P=0.543      P=0.495N     P=0.747N     P=0.747N    |P=0.457N     P=0.253      P=0.505      (e)          |
|=================================================================================================================================|
       Date:  10/19/99                           EXPERIMENT: 88050 TEST: 06                                            Page 18
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 METHACRYLONITRILE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|                                                        |0.0%         4.6%         0.0%         0.0%         |
|TERMINAL (d)       |                                                        |0/35 (0%)    1/35 (3%)    0/43 (0%)    0/25 (0%)    |
|FIRST INCIDENCE    |                                                        |---          711          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.459N     P=0.246      (e)          (e)          |
|POLY 3             |                                                        |P=0.434N     P=0.227      (e)          (e)          |
|POLY 1.5           |                                                        |P=0.428N     P=0.229      (e)          (e)          |
|POLY 6             |                                                        |P=0.432N     P=0.228      (e)          (e)          |
|LOGISTIC REGRESSION|                                                        |P=0.460N     P=0.229      (e)          (e)          |
|COCH-ARM / FISHERS |                                                        |P=0.405N     P=0.247      (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangioma                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.1%         0.0%         0.0%        |4.4%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/35 (0%)    1/43 (2%)    0/43 (0%)    0/22 (0%)   |2/35 (6%)    0/35 (0%)    0/43 (0%)    0/25 (0%)    |
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |730 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.646N     P=0.541      (e)          (e)         |P=0.124N     P=0.238N     P=0.194N     P=0.315N     |
|POLY 3             |     P=0.550N     P=0.512      (e)          (e)         |P=0.094N     P=0.248N     P=0.226N     P=0.299N     |
|POLY 1.5           |     P=0.561N     P=0.508      (e)          (e)         |P=0.102N     P=0.246N     P=0.230N     P=0.276N     |
|POLY 6             |     P=0.562N     P=0.516      (e)          (e)         |P=0.086N     P=0.247N     P=0.219N     P=0.319N     |
|LOGISTIC REGRESSION|     (e)          P=0.541      (e)          (e)         |P=0.124N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.567N     P=0.500      (e)          (e)         |P=0.115N     P=0.247N     P=0.247N     P=0.247N     |
|=================================================================================================================================|
       Date:  10/19/99                           EXPERIMENT: 88050 TEST: 06                                            Page 19
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 METHACRYLONITRILE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    1/50 (2%)    1/50 (2%)   |2/50 (4%)    3/50 (6%)    0/50 (0%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     6.6%         2.1%         2.1%         3.1%        |4.4%         6.8%         0.0%         8.6%         |
|TERMINAL (d)       |     2/35 (6%)    1/43 (2%)    0/43 (0%)    0/22 (0%)   |1/35 (3%)    1/35 (3%)    0/43 (0%)    3/25 (12%)   |
|FIRST INCIDENCE    |     650          729 (T)      655          481         |704          405          ---          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.354N     P=0.254N     P=0.263N     P=0.453N    |P=0.388      P=0.505      P=0.202N     P=0.346      |
|POLY 3             |     P=0.280N     P=0.287N     P=0.291N     P=0.439N    |P=0.444      P=0.487      P=0.226N     P=0.383      |
|POLY 1.5           |     P=0.272N     P=0.292N     P=0.296N     P=0.385N    |P=0.459      P=0.489      P=0.231N     P=0.424      |
|POLY 6             |     P=0.284N     P=0.281N     P=0.281N     P=0.490N    |P=0.440      P=0.491      P=0.220N     P=0.351      |
|LOGISTIC REGRESSION|     P=0.196N     P=0.295N     P=0.311N     P=0.304N    |P=0.484      P=0.544      P=0.225N     P=0.341      |
|COCH-ARM / FISHERS |     P=0.242N     P=0.309N     P=0.309N     P=0.309N    |P=0.500      P=0.500      P=0.247N     P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    1/50 (2%)    1/50 (2%)   |4/50 (8%)    3/50 (6%)    0/50 (0%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     6.6%         4.2%         2.1%         3.1%        |8.8%         6.8%         0.0%         8.6%         |
|TERMINAL (d)       |     2/35 (6%)    2/43 (5%)    0/43 (0%)    0/22 (0%)   |3/35 (9%)    1/35 (3%)    0/43 (0%)    3/25 (12%)   |
|FIRST INCIDENCE    |     650          729 (T)      655          481         |704          405          ---          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.309N     P=0.426N     P=0.263N     P=0.453N    |P=0.490N     P=0.495N     P=0.043N*    P=0.627      |
|POLY 3             |     P=0.247N     P=0.477N     P=0.291N     P=0.439N    |P=0.385N     P=0.516N     P=0.054N     P=0.639N     |
|POLY 1.5           |     P=0.235N     P=0.483N     P=0.296N     P=0.385N    |P=0.387N     P=0.514N     P=0.057N     P=0.591N     |
|POLY 6             |     P=0.255N     P=0.468N     P=0.281N     P=0.490N    |P=0.374N     P=0.511N     P=0.051N     P=0.625      |
|LOGISTIC REGRESSION|     P=0.171N     P=0.482N     P=0.311N     P=0.304N    |P=0.414N     P=0.482N     P=0.050N     P=0.624      |
|COCH-ARM / FISHERS |     P=0.199N     P=0.500N     P=0.309N     P=0.309N    |P=0.371N     P=0.500N     P=0.059N     P=0.500N     |
|=================================================================================================================================|
       Date:  10/19/99                           EXPERIMENT: 88050 TEST: 06                                            Page 20
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 METHACRYLONITRILE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        |
|     NOS, or Undifferentiated Cell Type                                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    3/50 (6%)    3/50 (6%)    1/50 (2%)   |9/50 (18%)   7/50 (14%)   7/50 (14%)   2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     4.5%         6.3%         6.4%         3.2%        |19.5%        15.9%        14.7%        5.7%         |
|TERMINAL (d)       |     2/35 (6%)    3/43 (7%)    3/43 (7%)    1/22 (5%)   |5/35 (14%)   5/35 (14%)   7/43 (16%)   2/25 (8%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |623          289          730 (T)      730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.536N     P=0.594      P=0.594      P=0.660N    |P=0.060N     P=0.404N     P=0.263N     P=0.098N     |
|POLY 3             |     P=0.509N     P=0.526      P=0.519      P=0.623N    |P=0.065N     P=0.432N     P=0.367N     P=0.073N     |
|POLY 1.5           |     P=0.449N     P=0.519      P=0.513      P=0.576N    |P=0.047N*    P=0.419N     P=0.376N     P=0.051N     |
|POLY 6             |     P=0.562N     P=0.537      P=0.532      P=0.664N    |P=0.084N     P=0.438N     P=0.356N     P=0.100N     |
|LOGISTIC REGRESSION|     P=0.536N     P=0.594      P=0.594      P=0.660N    |P=0.038N*    P=0.380N     P=0.369N     P=0.068N     |
|COCH-ARM / FISHERS |     P=0.343N     P=0.500      P=0.500      P=0.500N    |P=0.023N*    P=0.393N     P=0.393N     P=0.026N*    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     29/50 (58%)  35/50 (70%)  33/50 (66%)  19/50 (38%) |24/50 (48%)  15/50 (30%)  20/50 (40%)  13/50 (26%)  |
|POLY-3 ADJUSTED (b)|     60.7%        70.8%        67.6%        52.7%       |51.5%        34.6%        41.6%        36.1%        |
|TERMINAL (d)       |     21/35 (60%)  29/43 (67%)  30/43 (70%)  12/22 (55%) |20/35 (57%)  14/35 (40%)  19/43 (44%)  10/25 (40%)  |
|FIRST INCIDENCE    |     501          605          429          481         |362          638          589          480          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.531N     P=0.547      P=0.464N     P=0.565N    |P=0.204N     P=0.048N*    P=0.074N     P=0.190N     |
|POLY 3             |     P=0.247N     P=0.201      P=0.309      P=0.303N    |P=0.143N     P=0.076N     P=0.223N     P=0.116N     |
|POLY 1.5           |     P=0.088N     P=0.188      P=0.306      P=0.145N    |P=0.095N     P=0.069N     P=0.245N     P=0.064N     |
|POLY 6             |     P=0.454N     P=0.227      P=0.321      P=0.502N    |P=0.183N     P=0.075N     P=0.192N     P=0.174N     |
|LOGISTIC REGRESSION|     P=0.083N     P=0.167      P=0.284      P=0.176N    |P=0.186N     P=0.069N     P=0.220N     P=0.134N     |
|COCH-ARM / FISHERS |     P=0.008N**   P=0.149      P=0.268      P=0.036N*   |P=0.036N*    P=0.050N     P=0.273N     P=0.019N*    |
|=================================================================================================================================|
       Date:  10/19/99                           EXPERIMENT: 88050 TEST: 06                                            Page 21
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 METHACRYLONITRILE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     24/50 (48%)  17/50 (34%)  16/50 (32%)  8/50 (16%)  |19/50 (38%)  17/50 (34%)  17/50 (34%)  14/50 (28%)  |
|POLY-3 ADJUSTED (b)|     49.5%        34.3%        33.1%        23.8%       |40.3%        36.4%        34.4%        38.7%        |
|TERMINAL (d)       |     14/35 (40%)  11/43 (26%)  12/43 (28%)  3/22 (14%)  |11/35 (31%)  9/35 (26%)   11/43 (26%)  8/25 (32%)   |
|FIRST INCIDENCE    |     501          563          502          481         |607          289          589          581          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.047N*    P=0.058N     P=0.037N*    P=0.065N    |P=0.534N     P=0.442N     P=0.242N     P=0.528      |
|POLY 3             |     P=0.015N*    P=0.092N     P=0.075N     P=0.016N*   |P=0.452N     P=0.428N     P=0.349N     P=0.531N     |
|POLY 1.5           |     P=0.005N**   P=0.094N     P=0.072N     P=0.004N**  |P=0.354N     P=0.424N     P=0.374N     P=0.397N     |
|POLY 6             |     P=0.033N*    P=0.088N     P=0.073N     P=0.050N    |P=0.519N     P=0.431N     P=0.320N     P=0.539      |
|LOGISTIC REGRESSION|     P<0.001N**   P=0.158N     P=0.086N     P=0.002N**  |P=0.230N     P=0.365N     P=0.469N     P=0.522N     |
|COCH-ARM / FISHERS |     P<0.001N**   P=0.111N     P=0.076N     P<0.001N**  |P=0.174N     P=0.418N     P=0.418N     P=0.198N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      1.5          3 MG/KG      6 MG/KG     |0 MG/KG      1.5          3 MG/KG      6 MG/KG      |
|                   |                  MG/KG                                 |             MG/KG                                  |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     40/50 (80%)  41/50 (82%)  39/50 (78%)  24/50 (48%) |33/50 (66%)  28/50 (56%)  29/50 (58%)  21/50 (42%)  |
|POLY-3 ADJUSTED (b)|     81.9%        82.0%        78.2%        62.1%       |68.8%        59.5%        58.7%        57.0%        |
|TERMINAL (d)       |     27/35 (77%)  34/43 (79%)  33/43 (77%)  12/22 (55%) |24/35 (69%)  19/35 (54%)  23/43 (54%)  14/25 (56%)  |
|FIRST INCIDENCE    |     501          563          429          481         |362          289          589          480          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.360N     P=0.195N     P=0.121N     P=0.378N    |P=0.268N     P=0.261N     P=0.074N     P=0.346N     |
|POLY 3             |     P=0.017N*    P=0.595      P=0.418N     P=0.027N*   |P=0.164N     P=0.230N     P=0.204N     P=0.180N     |
|POLY 1.5           |     P=0.002N**   P=0.587      P=0.422N     P=0.005N**  |P=0.082N     P=0.225N     P=0.231N     P=0.077N     |
|POLY 6             |     P=0.071N     P=0.600N     P=0.415N     P=0.098N    |P=0.244N     P=0.225N     P=0.170N     P=0.310N     |
|LOGISTIC REGRESSION|     P<0.001N**   P=0.539      P=0.490N     P=0.010N*   |P=0.063N     P=0.208N     P=0.274N     P=0.179N     |
|COCH-ARM / FISHERS |     P<0.001N**   P=0.500      P=0.500N     P<0.001N**  |P=0.013N*    P=0.206N     P=0.268N     P=0.013N*    |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).