TDMS Study 88066-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11 LAB: A. D. Little POLYVINYL ALCOHOL DATE: 08/15/96 EXPERIMENT: 88066 TEST: 01 TIME: 14:06:51 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1 CONT: N01-ES-15330 ROUTE: VAGINAL NTP C#: 88066 PATHOLOGIST: GOAD, MARY CAS: 9002-89-5 ------------------------------------------------------------------------------------------------------------------------------------ VEHICLE CONTROL VS 25% REASONS FOR REMOVAL: ALL REMOVAL DATE RANGE: ALL TREATMENT GROUPS: INCLUDE 002 VEHICLE CONTROL INCLUDE 003 25% NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11 LAB: A. D. Little POLYVINYL ALCOHOL DATE: 08/15/96 EXPERIMENT: 88066 TEST: 01 TIME: 14:06:51 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE CONT: N01-ES-15330 ROUTE: VAGINAL NTP C#: 88066 PATHOLOGIST: GOAD, MARY CAS: 9002-89-5 POLYVINYL ALCOHOL STATISTICAL ANALYSIS OF SURVIVAL DATA FEMALE MICE FIRST TERMINAL SACRIFICE AT 729 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== | DOSE = VEHICLE CONTROL | | ---------------------------- | | | | TOTAL 100 UNCENSORED DEATHS 45 CENSORED DEATHS 4 TERMINAL 51 | | | | UNCENSORED DEATHS | | 205 532 542 548 548 548 588 588 609 611 | | 611 611 613 620 627 634 637 639 640 643 | | 646 654 654 658 661 668 671 675 675 675 | | 675 679 679 690 690 690 694 705 711 711 | | 717 721 722 722 728 | | CENSORED DEATHS | | 313 314 314 462 | | | |--------------------------------------------------------------------------------| | DOSE = 25% | | --------------------- | | | | TOTAL 100 UNCENSORED DEATHS 34 CENSORED DEATHS 5 TERMINAL 61 | | | | UNCENSORED DEATHS | | 72 324 372 514 542 553 619 620 620 624 | | 624 627 634 638 640 646 646 651 658 661 | | 668 675 682 686 688 690 696 697 701 704 | | 708 714 721 721 | | CENSORED DEATHS | | 112 313 504 507 637 | | | ================================================================================== POLYVINYL ALCOHOL STATISTICAL ANALYSIS OF SURVIVAL DATA FEMALE MICE FIRST TERMINAL SACRIFICE AT 729 DAYS ================================================================================== | KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) | | | |--------------------------------------------------------------------------------| | DOSE TIME (DAYS) | | 90 180 270 365 425 485 545 605 665 729 (A) | | | |--------------------------------------------------------------------------------| | | | |VEHICLE | 100.0 100.0 99.0 99.0 99.0 99.0 96.9 91.7 74.0 53.1 | |CONTROL | | | | | |25% | 99.0 99.0 99.0 98.0 97.0 97.0 94.9 93.8 79.1 64.4 | | | | | | | ================================================================================== ================================================================================== | SURVIVAL SUMMARY STATISTICS | | | | | |--------------------------------------------------------------------------------| | DOSE | | | | VEHICLE 25% | | CONTROL | |--------------------------------------------------------------------------------| |SURVIVAL AT END OF STUDY| 53.1% 64.4% | |(KAPLAN-MEIER) | | | | | |SIGNIFICANCE (B) | P=0.158N P=0.158N | |(LIFE TABLE) | | | | | |MEAN DAY OF | 639.2 618.7 | |NATURAL DEATHS (C) | (12.6) (22.4) | |(STANDARD ERROR) | | | | | |MEAN LIFE SPAN (D) | 673.5 675.8 | |(STANDARD ERROR) | ( 9.8) (11.7) | | | | ================================================================================== (A) FIRST TERMINAL SACRIFICE (B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT. SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS (COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N". (C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE (D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE) POLYVINYL ALCOHOL KAPLAN-MEIER SURVIVAL CURVES VEHICLE CONTROL = 1 25% = 2 ----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------ Plot of SURVIVAL*WEEK. Symbol is value of DOSE. | | 100 + 1 2 1 | 2 1 2 1 | 2 2 2 1 11 | 2 2 95 + 22 | 1 1 2 | | 1 1122 90 + | | 22 | 11 22 P 85 + 11122 E | R | 11 C | 22 E 80 + 2 2 N | 111 22 T | 222 | S 75 + 1 1 22 U | 11 R | 11 22 V | 22 I 70 + V | 22 A | L | 1 1 22 65 + | 2 2 | 11 | 11 60 + 11 | 11 | | 11 55 + | 1 1 | | 50 + | --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+-- 0 10 20 30 40 50 60 70 80 90 100 110 WEEK NOTE: 8 obs hidden.