TDMS Study 88066-01 Pathology Tables
NTP Experiment-Test: 88066-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:27:59
CORE STUDY
Facility: Arthur D. Little Life Science Laboratories
Chemical CAS #: 9002-89-5
Lock Date: 07/28/94
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88066-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:27:59
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD VEHICLE 25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 100 100 100
Early Deaths
Natural Death 24 20 21
Accidently Killed 10 4 5
Moribund Sacrifice 19 25 13
Survivors
Terminal Sacrifice 47 51 61
Animals Examined Microscopically 100 100 100
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (100) (100) (99)
Periesophageal Tissue, Inflammation, Chronic 1 (1%)
Gallbladder (76) (87) (79)
Hyperplasia 1 (1%)
Intestine Large, Colon (92) (93) (97)
Inflammation, Chronic 1 (1%) 1 (1%)
Lymphoid Tissue, Hyperplasia 1 (1%)
Serosa, Inflammation, Chronic 1 (1%)
Intestine Large, Rectum (89) (91) (96)
Inflammation, Chronic 1 (1%) 1 (1%)
Serosa, Inflammation, Chronic 1 (1%)
Intestine Large, Cecum (88) (92) (96)
Inflammation, Chronic 1 (1%)
Serosa, Inflammation, Chronic 1 (1%)
Intestine Small, Duodenum (88) (90) (92)
Inflammation, Chronic 1 (1%)
Epithelium, Hyperplasia 2 (2%) 1 (1%)
Serosa, Inflammation, Chronic 1 (1%)
Intestine Small, Jejunum (89) (90) (91)
Inflammation, Chronic 1 (1%)
Epithelium, Hyperplasia 1 (1%)
Peyer's Patch, Hyperplasia 2 (2%)
Serosa, Inflammation, Chronic 1 (1%)
Intestine Small, Ileum (88) (90) (92)
Inflammation, Chronic 1 (1%)
Epithelium, Hyperplasia 1 (1%)
Peyer's Patch, Hyperplasia, Lymphoid 1 (1%)
Serosa, Inflammation, Chronic 1 (1%)
Liver (99) (99) (100)
Atrophy 1 (1%) 10 (10%) 2 (2%)
Basophilic Focus 2 (2%) 1 (1%)
Clear Cell Focus 1 (1%) 10 (10%) 6 (6%)
Depletion Glycogen 20 (20%) 37 (37%) 30 (30%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 88066-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:27:59
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD VEHICLE 25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Eosinophilic Focus 2 (2%) 3 (3%) 2 (2%)
Fibrosis 1 (1%) 2 (2%)
Hematopoietic Cell Proliferation 23 (23%) 35 (35%) 25 (25%)
Infarct 1 (1%) 1 (1%)
Inflammation 3 (3%) 2 (2%) 1 (1%)
Necrosis 3 (3%) 5 (5%) 4 (4%)
Pigmentation, Hemosiderin 1 (1%) 2 (2%)
Vacuolization Cytoplasmic 38 (38%) 43 (43%) 39 (39%)
Centrilobular, Dilatation 1 (1%)
Centrilobular, Inflammation, Chronic 1 (1%)
Serosa, Inflammation, Chronic 1 (1%)
Mesentery (33) (25) (36)
Inflammation, Chronic 3 (9%) 1 (4%)
Necrosis 27 (82%) 23 (92%) 31 (86%)
Pancreas (97) (95) (98)
Atrophy 11 (11%) 8 (8%) 6 (6%)
Hyperplasia 1 (1%)
Hyperplasia, Lymphoid 1 (1%)
Inflammation, Chronic 18 (19%) 40 (42%) 36 (37%)
Necrosis 1 (1%)
Vacuolization Cytoplasmic 1 (1%)
Acinus, Atrophy 1 (1%)
Duct, Cyst 1 (1%)
Duct, Dilatation 1 (1%)
Salivary Glands (99) (97) (100)
Atrophy 6 (6%) 6 (6%) 5 (5%)
Inflammation, Chronic 52 (53%) 61 (63%) 58 (58%)
Stomach, Forestomach (94) (93) (97)
Inflammation 1 (1%)
Epithelium, Hyperplasia 1 (1%) 3 (3%)
Serosa, Inflammation, Chronic 1 (1%)
Stomach, Glandular (93) (93) (96)
Ectopic Liver 1 (1%)
Hemorrhage 1 (1%)
Inflammation, Chronic 1 (1%) 1 (1%)
Epithelium, Atrophy 1 (1%)
Epithelium, Hyperplasia 1 (1%) 1 (1%)
Epithelium, Metaplasia, Squamous 1 (1%)
Epithelium, Mineralization 1 (1%)
Serosa, Inflammation, Chronic 1 (1%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 88066-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:27:59
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD VEHICLE 25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (2)
Aorta, Degeneration 1 (100%)
Aorta, Metaplasia, Osseous 1 (50%)
Heart (100) (99) (100)
Cardiomyopathy 2 (2%) 4 (4%) 6 (6%)
Degeneration 83 (83%) 92 (93%) 90 (90%)
Inflammation, Chronic 1 (1%) 1 (1%) 1 (1%)
Mineralization 1 (1%)
Thrombosis 1 (1%)
Epicardium, Hyperplasia, Lymphoid 1 (1%)
Epicardium, Mineralization 1 (1%)
Valve, Thrombosis 1 (1%) 3 (3%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (100) (94) (97)
Accessory Adrenal Cortical Nodule 1 (1%) 4 (4%) 1 (1%)
Angiectasis 2 (2%)
Atrophy 1 (1%)
Hematopoietic Cell Proliferation 1 (1%)
Hemorrhage 1 (1%)
Vacuolization Cytoplasmic 1 (1%)
Capsule, Hyperplasia 4 (4%) 5 (5%) 7 (7%)
Capsule, Inflammation, Chronic 2 (2%)
Zona Glomerulosa, Atrophy 1 (1%)
Zona Glomerulosa, Hyperplasia 11 (11%) 9 (10%) 17 (18%)
Zona Reticularis, Hematopoietic Cell
Proliferation 1 (1%)
Zona Reticularis, Hyperplasia 6 (6%) 4 (4%) 3 (3%)
Adrenal Medulla (99) (94) (92)
Hemorrhage 1 (1%)
Islets, Pancreatic (97) (94) (97)
Atrophy 2 (2%) 2 (2%)
Hyperplasia 70 (72%) 80 (85%) 78 (80%)
Infiltration Cellular, Lymphocyte 1 (1%)
Necrosis 1 (1%)
Parathyroid Gland (59) (59) (69)
Cyst 1 (2%)
Hyperplasia 2 (3%) 1 (1%)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation, Chronic 1 (1%)
Pituitary Gland (88) (86) (84)
Atrophy 1 (1%)
Hemorrhage 2 (2%) 1 (1%)
Pigmentation, Hemosiderin 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 88066-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:27:59
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD VEHICLE 25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Angiectasis 1 (1%)
Pars Distalis, Hyperplasia 27 (31%) 28 (33%) 29 (35%)
Pars Intermedia, Angiectasis 1 (1%)
Pars Intermedia, Hyperplasia 1 (1%)
Thyroid Gland (100) (96) (100)
Inflammation, Chronic 1 (1%)
Follicular Cell, Cyst 1 (1%)
Follicular Cell, Hyperplasia 57 (57%) 57 (59%) 58 (58%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (89) (81) (83)
Atrophy 29 (33%) 26 (32%) 18 (22%)
Hyperplasia 4 (4%) 8 (10%) 10 (12%)
Inflammation, Chronic 2 (2%) 1 (1%)
Ovary (95) (97) (97)
Angiectasis 1 (1%) 1 (1%)
Atrophy 1 (1%)
Cyst 13 (14%) 13 (13%) 15 (15%)
Hemorrhage 2 (2%) 1 (1%) 2 (2%)
Hyperplasia, Lymphoid 1 (1%)
Hyperplasia, Tubulostromal 1 (1%)
Inflammation, Acute 1 (1%)
Inflammation, Chronic 2 (2%) 2 (2%)
Necrosis 1 (1%) 2 (2%) 4 (4%)
Thrombosis 2 (2%) 2 (2%) 1 (1%)
Periovarian Tissue, Inflammation, Chronic 2 (2%)
Uterus (100) (100) (100)
Amyloid Deposition 1 (1%)
Diestrus 1 (1%)
Hemorrhage 2 (2%) 1 (1%)
Hydrometra 7 (7%) 2 (2%) 2 (2%)
Inflammation 2 (2%)
Inflammation, Chronic Active 1 (1%) 1 (1%)
Endometrium, Angiectasis 1 (1%) 1 (1%)
Endometrium, Hemorrhage 1 (1%)
Endometrium, Hyperplasia, Cystic 90 (90%) 97 (97%) 98 (98%)
Serosa, Inflammation, Chronic 2 (2%)
Vagina (97) (99) (99)
Diestrus 1 (1%)
Inflammation, Acute 2 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 88066-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:27:59
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD VEHICLE 25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Inflammation, Chronic 2 (2%) 1 (1%)
Epithelium, Hyperplasia 1 (1%)
Epithelium, Inflammation, Chronic 1 (1%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (100) (98) (100)
Amyloid Deposition 1 (1%)
Depletion Cellular 1 (1%)
Hyperplasia 12 (12%) 16 (16%) 11 (11%)
Infiltration Cellular, Histiocyte 1 (1%)
Myelofibrosis 19 (19%) 19 (19%) 26 (26%)
Pigmentation, Hemosiderin 1 (1%)
Lymph Node (15) (21) (21)
Ectasia 1 (5%)
Hyperplasia 2 (13%) 3 (14%)
Infiltration Cellular, Plasma Cell 1 (5%)
Bronchial, Hemorrhage 1 (7%)
Iliac, Hemorrhage, Chronic 1 (5%)
Iliac, Hyperplasia 1 (5%) 3 (14%)
Iliac, Inflammation, Acute 1 (5%)
Mediastinal, Hemorrhage 1 (7%)
Mediastinal, Hyperplasia 1 (7%) 3 (14%) 4 (19%)
Renal, Hemorrhage 1 (7%)
Renal, Hyperplasia 1 (5%)
Renal, Inflammation, Acute 1 (5%)
Lymph Node, Mandibular (92) (94) (93)
Atrophy 12 (13%) 6 (6%) 12 (13%)
Hemorrhage 1 (1%)
Hyperplasia 16 (17%) 18 (19%) 10 (11%)
Hyperplasia, Lymphoid 1 (1%)
Infiltration Cellular, Histiocyte 1 (1%)
Necrosis 2 (2%)
Pigmentation, Hemosiderin 2 (2%) 2 (2%) 3 (3%)
Lymph Node, Mesenteric (90) (93) (93)
Atrophy 12 (13%) 14 (15%) 10 (11%)
Hemorrhage 1 (1%)
Hyperplasia 7 (8%) 6 (6%) 6 (6%)
Inflammation, Chronic 2 (2%) 2 (2%) 2 (2%)
Necrosis 1 (1%) 1 (1%)
Pigmentation, Hemosiderin 1 (1%)
Spleen (98) (96) (98)
Fibrosis 1 (1%)
Hematopoietic Cell Proliferation 52 (53%) 56 (58%) 59 (60%)
Inflammation, Chronic 1 (1%)
Necrosis 2 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 88066-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:27:59
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD VEHICLE 25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Pigmentation, Hemosiderin 41 (42%) 49 (51%) 46 (47%)
Thrombosis 1 (1%)
Capsule, Inflammation, Chronic 1 (1%)
Lymphoid Follicle, Atrophy 8 (8%) 1 (1%) 4 (4%)
Lymphoid Follicle, Hyperplasia 52 (53%) 65 (68%) 64 (65%)
Red Pulp, Atrophy 7 (7%) 1 (1%) 3 (3%)
Thymus (98) (93) (99)
Atrophy 66 (67%) 82 (88%) 79 (80%)
Hemorrhage 2 (2%)
Hyperplasia, Lymphoid 1 (1%)
Inflammation, Chronic 1 (1%) 1 (1%)
Necrosis 1 (1%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (93) (92) (91)
Atrophy 1 (1%)
Hyperplasia 8 (9%) 5 (5%) 7 (8%)
Inflammation, Chronic 1 (1%)
Skin (98) (98) (100)
Edema 1 (1%) 2 (2%)
Inflammation, Chronic 1 (1%) 4 (4%)
Epidermis, Hyperplasia 1 (1%)
Hair Follicle, Atrophy 2 (2%) 2 (2%) 1 (1%)
Subcutaneous Tissue, Inflammation, Chronic 1 (1%)
Vulva, Inflammation, Chronic 1 (1%)
Vulva, Ulcer 1 (1%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (100) (100) (100)
Hyperostosis 1 (1%) 2 (2%)
Osteoporosis 1 (1%) 1 (1%)
Skeletal Muscle (9) (10) (8)
Degeneration 1 (10%)
Inflammation, Chronic 3 (33%)
Metaplasia, Osseous 1 (10%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (100) (99) (100)
Hydrocephalus 2 (2%) 3 (3%) 2 (2%)
Infiltration Cellular, Lymphocyte 1 (1%)
Inflammation, Chronic 1 (1%) 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 88066-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:27:59
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD VEHICLE 25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - CONT
Choroid Plexus, Hyperplasia 1 (1%)
Meninges, Infiltration Cellular, Lymphocyte 1 (1%)
Thalamus, Mineralization 46 (46%) 53 (54%) 33 (33%)
Peripheral Nerve (3) (4) (4)
Inflammation, Chronic 1 (33%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (100) (98) (100)
Edema 9 (9%) 9 (9%) 3 (3%)
Hemorrhage 8 (8%) 3 (3%) 2 (2%)
Infiltration Cellular 1 (1%)
Inflammation, Acute 7 (7%) 1 (1%)
Inflammation, Chronic 9 (9%) 17 (17%) 16 (16%)
Pigmentation, Hemosiderin 1 (1%)
Thrombosis 1 (1%) 1 (1%)
Alveolar Epithelium, Hyperplasia 1 (1%) 1 (1%)
Bronchus, Inflammation, Chronic 1 (1%)
Nose (100) (100) (100)
Hemorrhage 1 (1%) 1 (1%)
Respiratory Epithelium, Inflammation 22 (22%) 15 (15%) 22 (22%)
Trachea (100) (100) (100)
Peritracheal Tissue, Inflammation, Chronic 1 (1%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (4) (6) (3)
Atrophy 1 (25%)
Cataract 2 (33%)
Cornea, Inflammation, Chronic 3 (75%) 4 (67%) 3 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (100) (98) (100)
Congestion 1 (1%)
Hydronephrosis 1 (1%) 3 (3%) 2 (2%)
Inflammation 1 (1%) 1 (1%) 2 (2%)
Metaplasia, Osseous 1 (1%)
Mineralization 1 (1%)
Nephropathy 88 (88%) 90 (92%) 93 (93%)
Glomerulus, Amyloid Deposition 1 (1%) 1 (1%)
Urinary Bladder (96) (96) (98)
Atrophy 1 (1%)
Degeneration 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 88066-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:27:59
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD VEHICLE 25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Inflammation, Chronic 2 (2%) 3 (3%)
Serosa, Inflammation, Chronic 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------