TDMS Study 88066-01 Pathology Tables
NTP Experiment-Test: 88066-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96 Route: VAGINAL Time: 18:27:59 CORE STUDY Facility: Arthur D. Little Life Science Laboratories Chemical CAS #: 9002-89-5 Lock Date: 07/28/94 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 88066-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96 Route: VAGINAL Time: 18:27:59 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE UNTREATD VEHICLE 25% CONTROL CONTROL ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 100 100 100 Early Deaths Natural Death 24 20 21 Accidently Killed 10 4 5 Moribund Sacrifice 19 25 13 Survivors Terminal Sacrifice 47 51 61 Animals Examined Microscopically 100 100 100 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Esophagus (100) (100) (99) Periesophageal Tissue, Inflammation, Chronic 1 (1%) Gallbladder (76) (87) (79) Hyperplasia 1 (1%) Intestine Large, Colon (92) (93) (97) Inflammation, Chronic 1 (1%) 1 (1%) Lymphoid Tissue, Hyperplasia 1 (1%) Serosa, Inflammation, Chronic 1 (1%) Intestine Large, Rectum (89) (91) (96) Inflammation, Chronic 1 (1%) 1 (1%) Serosa, Inflammation, Chronic 1 (1%) Intestine Large, Cecum (88) (92) (96) Inflammation, Chronic 1 (1%) Serosa, Inflammation, Chronic 1 (1%) Intestine Small, Duodenum (88) (90) (92) Inflammation, Chronic 1 (1%) Epithelium, Hyperplasia 2 (2%) 1 (1%) Serosa, Inflammation, Chronic 1 (1%) Intestine Small, Jejunum (89) (90) (91) Inflammation, Chronic 1 (1%) Epithelium, Hyperplasia 1 (1%) Peyer's Patch, Hyperplasia 2 (2%) Serosa, Inflammation, Chronic 1 (1%) Intestine Small, Ileum (88) (90) (92) Inflammation, Chronic 1 (1%) Epithelium, Hyperplasia 1 (1%) Peyer's Patch, Hyperplasia, Lymphoid 1 (1%) Serosa, Inflammation, Chronic 1 (1%) Liver (99) (99) (100) Atrophy 1 (1%) 10 (10%) 2 (2%) Basophilic Focus 2 (2%) 1 (1%) Clear Cell Focus 1 (1%) 10 (10%) 6 (6%) Depletion Glycogen 20 (20%) 37 (37%) 30 (30%) a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 88066-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96 Route: VAGINAL Time: 18:27:59 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE UNTREATD VEHICLE 25% CONTROL CONTROL ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Eosinophilic Focus 2 (2%) 3 (3%) 2 (2%) Fibrosis 1 (1%) 2 (2%) Hematopoietic Cell Proliferation 23 (23%) 35 (35%) 25 (25%) Infarct 1 (1%) 1 (1%) Inflammation 3 (3%) 2 (2%) 1 (1%) Necrosis 3 (3%) 5 (5%) 4 (4%) Pigmentation, Hemosiderin 1 (1%) 2 (2%) Vacuolization Cytoplasmic 38 (38%) 43 (43%) 39 (39%) Centrilobular, Dilatation 1 (1%) Centrilobular, Inflammation, Chronic 1 (1%) Serosa, Inflammation, Chronic 1 (1%) Mesentery (33) (25) (36) Inflammation, Chronic 3 (9%) 1 (4%) Necrosis 27 (82%) 23 (92%) 31 (86%) Pancreas (97) (95) (98) Atrophy 11 (11%) 8 (8%) 6 (6%) Hyperplasia 1 (1%) Hyperplasia, Lymphoid 1 (1%) Inflammation, Chronic 18 (19%) 40 (42%) 36 (37%) Necrosis 1 (1%) Vacuolization Cytoplasmic 1 (1%) Acinus, Atrophy 1 (1%) Duct, Cyst 1 (1%) Duct, Dilatation 1 (1%) Salivary Glands (99) (97) (100) Atrophy 6 (6%) 6 (6%) 5 (5%) Inflammation, Chronic 52 (53%) 61 (63%) 58 (58%) Stomach, Forestomach (94) (93) (97) Inflammation 1 (1%) Epithelium, Hyperplasia 1 (1%) 3 (3%) Serosa, Inflammation, Chronic 1 (1%) Stomach, Glandular (93) (93) (96) Ectopic Liver 1 (1%) Hemorrhage 1 (1%) Inflammation, Chronic 1 (1%) 1 (1%) Epithelium, Atrophy 1 (1%) Epithelium, Hyperplasia 1 (1%) 1 (1%) Epithelium, Metaplasia, Squamous 1 (1%) Epithelium, Mineralization 1 (1%) Serosa, Inflammation, Chronic 1 (1%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 88066-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96 Route: VAGINAL Time: 18:27:59 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE UNTREATD VEHICLE 25% CONTROL CONTROL ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Blood Vessel (1) (2) Aorta, Degeneration 1 (100%) Aorta, Metaplasia, Osseous 1 (50%) Heart (100) (99) (100) Cardiomyopathy 2 (2%) 4 (4%) 6 (6%) Degeneration 83 (83%) 92 (93%) 90 (90%) Inflammation, Chronic 1 (1%) 1 (1%) 1 (1%) Mineralization 1 (1%) Thrombosis 1 (1%) Epicardium, Hyperplasia, Lymphoid 1 (1%) Epicardium, Mineralization 1 (1%) Valve, Thrombosis 1 (1%) 3 (3%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (100) (94) (97) Accessory Adrenal Cortical Nodule 1 (1%) 4 (4%) 1 (1%) Angiectasis 2 (2%) Atrophy 1 (1%) Hematopoietic Cell Proliferation 1 (1%) Hemorrhage 1 (1%) Vacuolization Cytoplasmic 1 (1%) Capsule, Hyperplasia 4 (4%) 5 (5%) 7 (7%) Capsule, Inflammation, Chronic 2 (2%) Zona Glomerulosa, Atrophy 1 (1%) Zona Glomerulosa, Hyperplasia 11 (11%) 9 (10%) 17 (18%) Zona Reticularis, Hematopoietic Cell Proliferation 1 (1%) Zona Reticularis, Hyperplasia 6 (6%) 4 (4%) 3 (3%) Adrenal Medulla (99) (94) (92) Hemorrhage 1 (1%) Islets, Pancreatic (97) (94) (97) Atrophy 2 (2%) 2 (2%) Hyperplasia 70 (72%) 80 (85%) 78 (80%) Infiltration Cellular, Lymphocyte 1 (1%) Necrosis 1 (1%) Parathyroid Gland (59) (59) (69) Cyst 1 (2%) Hyperplasia 2 (3%) 1 (1%) Infiltration Cellular, Lymphocyte 1 (2%) Inflammation, Chronic 1 (1%) Pituitary Gland (88) (86) (84) Atrophy 1 (1%) Hemorrhage 2 (2%) 1 (1%) Pigmentation, Hemosiderin 1 (1%) a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 88066-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96 Route: VAGINAL Time: 18:27:59 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE UNTREATD VEHICLE 25% CONTROL CONTROL ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Pars Distalis, Angiectasis 1 (1%) Pars Distalis, Hyperplasia 27 (31%) 28 (33%) 29 (35%) Pars Intermedia, Angiectasis 1 (1%) Pars Intermedia, Hyperplasia 1 (1%) Thyroid Gland (100) (96) (100) Inflammation, Chronic 1 (1%) Follicular Cell, Cyst 1 (1%) Follicular Cell, Hyperplasia 57 (57%) 57 (59%) 58 (58%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (89) (81) (83) Atrophy 29 (33%) 26 (32%) 18 (22%) Hyperplasia 4 (4%) 8 (10%) 10 (12%) Inflammation, Chronic 2 (2%) 1 (1%) Ovary (95) (97) (97) Angiectasis 1 (1%) 1 (1%) Atrophy 1 (1%) Cyst 13 (14%) 13 (13%) 15 (15%) Hemorrhage 2 (2%) 1 (1%) 2 (2%) Hyperplasia, Lymphoid 1 (1%) Hyperplasia, Tubulostromal 1 (1%) Inflammation, Acute 1 (1%) Inflammation, Chronic 2 (2%) 2 (2%) Necrosis 1 (1%) 2 (2%) 4 (4%) Thrombosis 2 (2%) 2 (2%) 1 (1%) Periovarian Tissue, Inflammation, Chronic 2 (2%) Uterus (100) (100) (100) Amyloid Deposition 1 (1%) Diestrus 1 (1%) Hemorrhage 2 (2%) 1 (1%) Hydrometra 7 (7%) 2 (2%) 2 (2%) Inflammation 2 (2%) Inflammation, Chronic Active 1 (1%) 1 (1%) Endometrium, Angiectasis 1 (1%) 1 (1%) Endometrium, Hemorrhage 1 (1%) Endometrium, Hyperplasia, Cystic 90 (90%) 97 (97%) 98 (98%) Serosa, Inflammation, Chronic 2 (2%) Vagina (97) (99) (99) Diestrus 1 (1%) Inflammation, Acute 2 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 88066-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96 Route: VAGINAL Time: 18:27:59 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE UNTREATD VEHICLE 25% CONTROL CONTROL ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM - CONT Inflammation, Chronic 2 (2%) 1 (1%) Epithelium, Hyperplasia 1 (1%) Epithelium, Inflammation, Chronic 1 (1%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (100) (98) (100) Amyloid Deposition 1 (1%) Depletion Cellular 1 (1%) Hyperplasia 12 (12%) 16 (16%) 11 (11%) Infiltration Cellular, Histiocyte 1 (1%) Myelofibrosis 19 (19%) 19 (19%) 26 (26%) Pigmentation, Hemosiderin 1 (1%) Lymph Node (15) (21) (21) Ectasia 1 (5%) Hyperplasia 2 (13%) 3 (14%) Infiltration Cellular, Plasma Cell 1 (5%) Bronchial, Hemorrhage 1 (7%) Iliac, Hemorrhage, Chronic 1 (5%) Iliac, Hyperplasia 1 (5%) 3 (14%) Iliac, Inflammation, Acute 1 (5%) Mediastinal, Hemorrhage 1 (7%) Mediastinal, Hyperplasia 1 (7%) 3 (14%) 4 (19%) Renal, Hemorrhage 1 (7%) Renal, Hyperplasia 1 (5%) Renal, Inflammation, Acute 1 (5%) Lymph Node, Mandibular (92) (94) (93) Atrophy 12 (13%) 6 (6%) 12 (13%) Hemorrhage 1 (1%) Hyperplasia 16 (17%) 18 (19%) 10 (11%) Hyperplasia, Lymphoid 1 (1%) Infiltration Cellular, Histiocyte 1 (1%) Necrosis 2 (2%) Pigmentation, Hemosiderin 2 (2%) 2 (2%) 3 (3%) Lymph Node, Mesenteric (90) (93) (93) Atrophy 12 (13%) 14 (15%) 10 (11%) Hemorrhage 1 (1%) Hyperplasia 7 (8%) 6 (6%) 6 (6%) Inflammation, Chronic 2 (2%) 2 (2%) 2 (2%) Necrosis 1 (1%) 1 (1%) Pigmentation, Hemosiderin 1 (1%) Spleen (98) (96) (98) Fibrosis 1 (1%) Hematopoietic Cell Proliferation 52 (53%) 56 (58%) 59 (60%) Inflammation, Chronic 1 (1%) Necrosis 2 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 6 NTP Experiment-Test: 88066-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96 Route: VAGINAL Time: 18:27:59 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE UNTREATD VEHICLE 25% CONTROL CONTROL ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Pigmentation, Hemosiderin 41 (42%) 49 (51%) 46 (47%) Thrombosis 1 (1%) Capsule, Inflammation, Chronic 1 (1%) Lymphoid Follicle, Atrophy 8 (8%) 1 (1%) 4 (4%) Lymphoid Follicle, Hyperplasia 52 (53%) 65 (68%) 64 (65%) Red Pulp, Atrophy 7 (7%) 1 (1%) 3 (3%) Thymus (98) (93) (99) Atrophy 66 (67%) 82 (88%) 79 (80%) Hemorrhage 2 (2%) Hyperplasia, Lymphoid 1 (1%) Inflammation, Chronic 1 (1%) 1 (1%) Necrosis 1 (1%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (93) (92) (91) Atrophy 1 (1%) Hyperplasia 8 (9%) 5 (5%) 7 (8%) Inflammation, Chronic 1 (1%) Skin (98) (98) (100) Edema 1 (1%) 2 (2%) Inflammation, Chronic 1 (1%) 4 (4%) Epidermis, Hyperplasia 1 (1%) Hair Follicle, Atrophy 2 (2%) 2 (2%) 1 (1%) Subcutaneous Tissue, Inflammation, Chronic 1 (1%) Vulva, Inflammation, Chronic 1 (1%) Vulva, Ulcer 1 (1%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (100) (100) (100) Hyperostosis 1 (1%) 2 (2%) Osteoporosis 1 (1%) 1 (1%) Skeletal Muscle (9) (10) (8) Degeneration 1 (10%) Inflammation, Chronic 3 (33%) Metaplasia, Osseous 1 (10%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (100) (99) (100) Hydrocephalus 2 (2%) 3 (3%) 2 (2%) Infiltration Cellular, Lymphocyte 1 (1%) Inflammation, Chronic 1 (1%) 1 (1%) a Number of animals examined microscopically at site and number of animals with lesion Page 7 NTP Experiment-Test: 88066-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96 Route: VAGINAL Time: 18:27:59 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE UNTREATD VEHICLE 25% CONTROL CONTROL ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - CONT Choroid Plexus, Hyperplasia 1 (1%) Meninges, Infiltration Cellular, Lymphocyte 1 (1%) Thalamus, Mineralization 46 (46%) 53 (54%) 33 (33%) Peripheral Nerve (3) (4) (4) Inflammation, Chronic 1 (33%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (100) (98) (100) Edema 9 (9%) 9 (9%) 3 (3%) Hemorrhage 8 (8%) 3 (3%) 2 (2%) Infiltration Cellular 1 (1%) Inflammation, Acute 7 (7%) 1 (1%) Inflammation, Chronic 9 (9%) 17 (17%) 16 (16%) Pigmentation, Hemosiderin 1 (1%) Thrombosis 1 (1%) 1 (1%) Alveolar Epithelium, Hyperplasia 1 (1%) 1 (1%) Bronchus, Inflammation, Chronic 1 (1%) Nose (100) (100) (100) Hemorrhage 1 (1%) 1 (1%) Respiratory Epithelium, Inflammation 22 (22%) 15 (15%) 22 (22%) Trachea (100) (100) (100) Peritracheal Tissue, Inflammation, Chronic 1 (1%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (4) (6) (3) Atrophy 1 (25%) Cataract 2 (33%) Cornea, Inflammation, Chronic 3 (75%) 4 (67%) 3 (100%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (100) (98) (100) Congestion 1 (1%) Hydronephrosis 1 (1%) 3 (3%) 2 (2%) Inflammation 1 (1%) 1 (1%) 2 (2%) Metaplasia, Osseous 1 (1%) Mineralization 1 (1%) Nephropathy 88 (88%) 90 (92%) 93 (93%) Glomerulus, Amyloid Deposition 1 (1%) 1 (1%) Urinary Bladder (96) (96) (98) Atrophy 1 (1%) Degeneration 1 (1%) a Number of animals examined microscopically at site and number of animals with lesion Page 8 NTP Experiment-Test: 88066-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96 Route: VAGINAL Time: 18:27:59 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE UNTREATD VEHICLE 25% CONTROL CONTROL ____________________________________________________________________________________________________________________________________ URINARY SYSTEM - CONT Inflammation, Chronic 2 (2%) 3 (3%) Serosa, Inflammation, Chronic 1 (1%) a Number of animals examined microscopically at site and number of animals with lesion Page 9 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------