TDMS Study 88066-01 Pathology Tables
NTP Experiment-Test: 88066-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:44:40
CORE STUDY
Facility: Arthur D. Little Life Science Laboratories
Chemical CAS #: 9002-89-5
Lock Date: 07/28/94
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 88066-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:44:40
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD VEHICLE 25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 100 100 100
Early Deaths
Natural Death 24 20 21
Accidently Killed 10 4 5
Moribund Sacrifice 19 25 13
Survivors
Terminal Sacrifice 47 51 61
Animals Examined Microscopically 100 100 100
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ALIMENTARY SYSTEM
Gallbladder (76) (87) (79)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (1%)
Intestine Small, Duodenum (88) (90) (92)
Polyp Adenomatous 1 (1%) 1 (1%)
Intestine Small, Jejunum (89) (90) (91)
Squamous Cell Carcinoma, Metastatic, Stomach,
Forestomach 1 (1%)
Intestine Small, Ileum (88) (90) (92)
Liver (99) (99) (100)
Hepatocellular Carcinoma 11 (11%) 18 (18%) 20 (20%)
Hepatocellular Adenoma 25 (25%) 43 (43%) 36 (36%)
Hepatocellular Adenoma, Multiple 30 (30%) 13 (13%) 19 (19%)
Hepatocholangiocarcinoma 2 (2%)
Histiocytic Sarcoma 4 (4%) 2 (2%) 1 (1%)
Serosa, Fibrosarcoma, Metastatic, Skeletal
Muscle 1 (1%)
Mesentery (33) (25) (36)
Carcinoma, Metastatic, Islets, Pancreatic 1 (4%)
Hepatocholangiocarcinoma, Metastatic, Liver 2 (6%)
Histiocytic Sarcoma 1 (3%)
Rhabdomyosarcoma, Metastatic, Skeletal Muscle 1 (3%)
Sarcoma 1 (3%)
Squamous Cell Carcinoma, Metastatic, Stomach,
Forestomach 1 (3%)
Yolk Sac Carcinoma, Metastatic, Ovary 1 (3%)
Pancreas (97) (95) (98)
Adenoma 1 (1%)
Carcinoma 1 (1%)
Fibrosarcoma, Metastatic, Skeletal Muscle 1 (1%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (1%)
Squamous Cell Carcinoma, Metastatic, Stomach,
Forestomach 1 (1%)
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NTP Experiment-Test: 88066-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:44:40
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD VEHICLE 25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Salivary Glands (99) (97) (100)
Stomach, Forestomach (94) (93) (97)
Squamous Cell Carcinoma 1 (1%)
Squamous Cell Papilloma 2 (2%)
Stomach, Glandular (93) (93) (96)
Leiomyosarcoma 1 (1%)
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CARDIOVASCULAR SYSTEM
Heart (100) (99) (100)
Hemangiosarcoma 1 (1%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (1%)
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ENDOCRINE SYSTEM
Adrenal Cortex (100) (94) (97)
Carcinoma, Metastatic, Islets, Pancreatic 1 (1%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (1%)
Histiocytic Sarcoma 1 (1%)
Squamous Cell Carcinoma, Metastatic, Stomach,
Forestomach 1 (1%)
Capsule, Adenoma 1 (1%)
Capsule, Carcinoma 1 (1%)
Adrenal Medulla (99) (94) (92)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (1%)
Pheochromocytoma Benign 2 (2%)
Islets, Pancreatic (97) (94) (97)
Adenoma 3 (3%) 1 (1%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (1%)
Parathyroid Gland (59) (59) (69)
Adenoma 1 (1%)
Pituitary Gland (88) (86) (84)
Pars Distalis, Adenoma 13 (15%) 9 (10%) 10 (12%)
Pars Intermedia, Adenoma 1 (1%)
Thyroid Gland (100) (96) (100)
C-Cell, Adenoma 1 (1%)
Follicular Cell, Adenoma 8 (8%) 9 (9%) 11 (11%)
Follicular Cell, Carcinoma 1 (1%)
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NTP Experiment-Test: 88066-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:44:40
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD VEHICLE 25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Squamous Cell Carcinoma, Metastatic, Stomach,
Forestomach 1 (100%)
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GENITAL SYSTEM
Ovary (95) (97) (97)
Cystadenoma 6 (6%) 5 (5%) 3 (3%)
Granulosa Cell Tumor Benign 1 (1%) 2 (2%)
Hemangiosarcoma 1 (1%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (1%) 1 (1%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (1%)
Histiocytic Sarcoma 3 (3%) 1 (1%)
Liposarcoma 1 (1%)
Luteoma 1 (1%) 2 (2%)
Squamous Cell Carcinoma, Metastatic, Stomach,
Forestomach 1 (1%)
Teratoma Benign 1 (1%)
Yolk Sac Carcinoma 2 (2%)
Uterus (100) (100) (100)
Carcinoma 1 (1%)
Deciduoma NOS 1 (1%)
Granular Cell Tumor Benign 1 (1%) 1 (1%)
Hamartoma 1 (1%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (1%)
Histiocytic Sarcoma 4 (4%) 2 (2%) 1 (1%)
Leiomyoma 1 (1%)
Polyp Stromal 1 (1%) 3 (3%)
Sarcoma Stromal 2 (2%)
Squamous Cell Carcinoma, Metastatic, Stomach,
Forestomach 1 (1%)
Serosa, Fibrosarcoma, Metastatic, Skeletal
Muscle 1 (1%)
Vagina (97) (99) (99)
Histiocytic Sarcoma 1 (1%)
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HEMATOPOIETIC SYSTEM
Bone Marrow (100) (98) (100)
Histiocytic Sarcoma 1 (1%)
Lymph Node (15) (21) (21)
Liposarcoma 1 (5%)
Plasma Cell Tumor Benign 1 (5%)
Squamous Cell Carcinoma, Metastatic, Stomach,
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NTP Experiment-Test: 88066-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:44:40
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD VEHICLE 25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Forestomach 1 (7%)
Iliac, Histiocytic Sarcoma 1 (7%) 1 (5%)
Inguinal, Fibrosarcoma, Metastatic, Skeletal
Muscle 1 (7%)
Mediastinal, Fibrosarcoma, Metastatic,
Skeletal Muscle 1 (7%)
Mediastinal, Histiocytic Sarcoma 1 (7%)
Mediastinal, Sarcoma, Metastatic, Uncertain
Primary Site 1 (5%)
Renal, Histiocytic Sarcoma 1 (7%) 1 (5%)
Lymph Node, Mandibular (92) (94) (93)
Plasma Cell Tumor Benign 1 (1%)
Lymph Node, Mesenteric (90) (93) (93)
Fibrosarcoma, Metastatic, Skeletal Muscle 1 (1%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (1%) 1 (1%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (1%)
Histiocytic Sarcoma 4 (4%)
Rhabdomyosarcoma, Metastatic, Skeletal Muscle 1 (1%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (1%)
Squamous Cell Carcinoma, Metastatic, Stomach,
Forestomach 1 (1%)
Spleen (98) (96) (98)
Fibrosarcoma, Metastatic, Skeletal Muscle 1 (1%)
Histiocytic Sarcoma 2 (2%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (1%)
Thymus (98) (93) (99)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (1%)
Fibrosarcoma, Metastatic, Skin 1 (1%)
Fibrosarcoma, Metastatic, Skeletal Muscle 1 (1%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (1%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (1%)
Thymoma Benign 1 (1%) 1 (1%)
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INTEGUMENTARY SYSTEM
Mammary Gland (93) (92) (91)
Adenoma 1 (1%)
Carcinoma 1 (1%)
Skin (98) (98) (100)
Fibrosarcoma 1 (1%)
Sarcoma 1 (1%)
Subcutaneous Tissue, Fibrosarcoma 1 (1%) 2 (2%)
Subcutaneous Tissue, Fibrous Histiocytoma 1 (1%)
Subcutaneous Tissue, Pinna, Fibrosarcoma 1 (1%)
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NTP Experiment-Test: 88066-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:44:40
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD VEHICLE 25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (100) (100) (100)
Pelvis, Sarcoma 1 (1%)
Skeletal Muscle (9) (10) (8)
Fibrosarcoma, Metastatic, Skeletal Muscle 1 (11%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (13%)
Rhabdomyosarcoma 2 (22%) 2 (20%) 2 (25%)
Sarcoma 1 (13%)
Squamous Cell Carcinoma, Metastatic, Stomach,
Forestomach 1 (11%)
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NERVOUS SYSTEM
Brain (100) (99) (100)
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RESPIRATORY SYSTEM
Lung (100) (98) (100)
Alveolar/Bronchiolar Adenoma 6 (6%) 7 (7%) 8 (8%)
Alveolar/Bronchiolar Carcinoma 3 (3%) 3 (3%) 5 (5%)
Carcinoma, Metastatic, Harderian Gland 1 (1%)
Fibrosarcoma, Metastatic, Skin 1 (1%)
Hepatocellular Carcinoma, Metastatic, Liver 4 (4%) 2 (2%)
Hepatocholangiocarcinoma, Metastatic, Liver 2 (2%)
Histiocytic Sarcoma 2 (2%) 1 (1%)
Osteosarcoma, Metastatic, Tissue NOS 1 (1%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (1%) 1 (1%)
Yolk Sac Carcinoma, Metastatic, Ovary 1 (1%)
Nose (100) (100) (100)
Carcinoma 1 (1%)
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SPECIAL SENSES SYSTEM
Harderian Gland (5) (11) (6)
Adenoma 4 (80%) 9 (82%) 4 (67%)
Carcinoma 1 (20%) 2 (18%) 1 (17%)
Zymbal's Gland (3)
Carcinoma 1 (33%)
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NTP Experiment-Test: 88066-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:44:40
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD VEHICLE 25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (100) (98) (100)
Adenoma 1 (1%)
Histiocytic Sarcoma 1 (1%)
Urinary Bladder (96) (96) (98)
Histiocytic Sarcoma 1 (1%)
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SYSTEMIC LESIONS
Multiple Organs *(100) *(100) *(100)
Histiocytic Sarcoma 4 (4%) 2 (2%) 1 (1%)
Lymphoma Malignant 13 (13%) 14 (14%) 18 (18%)
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* Number of animals with any tissue examined microscopically
Page 7
NTP Experiment-Test: 88066-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:44:40
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD VEHICLE 25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 78 82 88
Total Primary Neoplasms 145 160 161
Total Animals with Benign Neoplasms 67 72 69
Total Benign Neoplasms 103 109 102
Total Animals with Malignant Neoplasms 38 40 51
Total Malignant Neoplasms 42 51 58
Total Animals with Metastatic Neoplasms 11 7 4
Total Metastatic Neoplasm 33 13 15
Total Animals with Malignant Neoplasms 2 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
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a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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