TDMS Study 88066-01 Pathology Tables
NTP Experiment-Test: 88066-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96 Route: VAGINAL Time: 18:44:40 CORE STUDY Facility: Arthur D. Little Life Science Laboratories Chemical CAS #: 9002-89-5 Lock Date: 07/28/94 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 88066-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96 Route: VAGINAL Time: 18:44:40 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE UNTREATD VEHICLE 25% CONTROL CONTROL ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 100 100 100 Early Deaths Natural Death 24 20 21 Accidently Killed 10 4 5 Moribund Sacrifice 19 25 13 Survivors Terminal Sacrifice 47 51 61 Animals Examined Microscopically 100 100 100 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Gallbladder (76) (87) (79) Hepatocholangiocarcinoma, Metastatic, Liver 1 (1%) Intestine Small, Duodenum (88) (90) (92) Polyp Adenomatous 1 (1%) 1 (1%) Intestine Small, Jejunum (89) (90) (91) Squamous Cell Carcinoma, Metastatic, Stomach, Forestomach 1 (1%) Intestine Small, Ileum (88) (90) (92) Liver (99) (99) (100) Hepatocellular Carcinoma 11 (11%) 18 (18%) 20 (20%) Hepatocellular Adenoma 25 (25%) 43 (43%) 36 (36%) Hepatocellular Adenoma, Multiple 30 (30%) 13 (13%) 19 (19%) Hepatocholangiocarcinoma 2 (2%) Histiocytic Sarcoma 4 (4%) 2 (2%) 1 (1%) Serosa, Fibrosarcoma, Metastatic, Skeletal Muscle 1 (1%) Mesentery (33) (25) (36) Carcinoma, Metastatic, Islets, Pancreatic 1 (4%) Hepatocholangiocarcinoma, Metastatic, Liver 2 (6%) Histiocytic Sarcoma 1 (3%) Rhabdomyosarcoma, Metastatic, Skeletal Muscle 1 (3%) Sarcoma 1 (3%) Squamous Cell Carcinoma, Metastatic, Stomach, Forestomach 1 (3%) Yolk Sac Carcinoma, Metastatic, Ovary 1 (3%) Pancreas (97) (95) (98) Adenoma 1 (1%) Carcinoma 1 (1%) Fibrosarcoma, Metastatic, Skeletal Muscle 1 (1%) Hepatocholangiocarcinoma, Metastatic, Liver 1 (1%) Squamous Cell Carcinoma, Metastatic, Stomach, Forestomach 1 (1%) Page 2 NTP Experiment-Test: 88066-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96 Route: VAGINAL Time: 18:44:40 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE UNTREATD VEHICLE 25% CONTROL CONTROL ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont Salivary Glands (99) (97) (100) Stomach, Forestomach (94) (93) (97) Squamous Cell Carcinoma 1 (1%) Squamous Cell Papilloma 2 (2%) Stomach, Glandular (93) (93) (96) Leiomyosarcoma 1 (1%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (100) (99) (100) Hemangiosarcoma 1 (1%) Hepatocellular Carcinoma, Metastatic, Liver 1 (1%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (100) (94) (97) Carcinoma, Metastatic, Islets, Pancreatic 1 (1%) Hepatocellular Carcinoma, Metastatic, Liver 1 (1%) Histiocytic Sarcoma 1 (1%) Squamous Cell Carcinoma, Metastatic, Stomach, Forestomach 1 (1%) Capsule, Adenoma 1 (1%) Capsule, Carcinoma 1 (1%) Adrenal Medulla (99) (94) (92) Hepatocholangiocarcinoma, Metastatic, Liver 1 (1%) Pheochromocytoma Benign 2 (2%) Islets, Pancreatic (97) (94) (97) Adenoma 3 (3%) 1 (1%) Hepatocholangiocarcinoma, Metastatic, Liver 1 (1%) Parathyroid Gland (59) (59) (69) Adenoma 1 (1%) Pituitary Gland (88) (86) (84) Pars Distalis, Adenoma 13 (15%) 9 (10%) 10 (12%) Pars Intermedia, Adenoma 1 (1%) Thyroid Gland (100) (96) (100) C-Cell, Adenoma 1 (1%) Follicular Cell, Adenoma 8 (8%) 9 (9%) 11 (11%) Follicular Cell, Carcinoma 1 (1%) ____________________________________________________________________________________________________________________________________ Page 3 NTP Experiment-Test: 88066-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96 Route: VAGINAL Time: 18:44:40 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE UNTREATD VEHICLE 25% CONTROL CONTROL ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM Tissue NOS (1) Squamous Cell Carcinoma, Metastatic, Stomach, Forestomach 1 (100%) ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (95) (97) (97) Cystadenoma 6 (6%) 5 (5%) 3 (3%) Granulosa Cell Tumor Benign 1 (1%) 2 (2%) Hemangiosarcoma 1 (1%) Hepatocellular Carcinoma, Metastatic, Liver 1 (1%) 1 (1%) Hepatocholangiocarcinoma, Metastatic, Liver 1 (1%) Histiocytic Sarcoma 3 (3%) 1 (1%) Liposarcoma 1 (1%) Luteoma 1 (1%) 2 (2%) Squamous Cell Carcinoma, Metastatic, Stomach, Forestomach 1 (1%) Teratoma Benign 1 (1%) Yolk Sac Carcinoma 2 (2%) Uterus (100) (100) (100) Carcinoma 1 (1%) Deciduoma NOS 1 (1%) Granular Cell Tumor Benign 1 (1%) 1 (1%) Hamartoma 1 (1%) Hepatocellular Carcinoma, Metastatic, Liver 1 (1%) Histiocytic Sarcoma 4 (4%) 2 (2%) 1 (1%) Leiomyoma 1 (1%) Polyp Stromal 1 (1%) 3 (3%) Sarcoma Stromal 2 (2%) Squamous Cell Carcinoma, Metastatic, Stomach, Forestomach 1 (1%) Serosa, Fibrosarcoma, Metastatic, Skeletal Muscle 1 (1%) Vagina (97) (99) (99) Histiocytic Sarcoma 1 (1%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (100) (98) (100) Histiocytic Sarcoma 1 (1%) Lymph Node (15) (21) (21) Liposarcoma 1 (5%) Plasma Cell Tumor Benign 1 (5%) Squamous Cell Carcinoma, Metastatic, Stomach, Page 4 NTP Experiment-Test: 88066-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96 Route: VAGINAL Time: 18:44:40 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE UNTREATD VEHICLE 25% CONTROL CONTROL ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont Forestomach 1 (7%) Iliac, Histiocytic Sarcoma 1 (7%) 1 (5%) Inguinal, Fibrosarcoma, Metastatic, Skeletal Muscle 1 (7%) Mediastinal, Fibrosarcoma, Metastatic, Skeletal Muscle 1 (7%) Mediastinal, Histiocytic Sarcoma 1 (7%) Mediastinal, Sarcoma, Metastatic, Uncertain Primary Site 1 (5%) Renal, Histiocytic Sarcoma 1 (7%) 1 (5%) Lymph Node, Mandibular (92) (94) (93) Plasma Cell Tumor Benign 1 (1%) Lymph Node, Mesenteric (90) (93) (93) Fibrosarcoma, Metastatic, Skeletal Muscle 1 (1%) Hepatocellular Carcinoma, Metastatic, Liver 1 (1%) 1 (1%) Hepatocholangiocarcinoma, Metastatic, Liver 1 (1%) Histiocytic Sarcoma 4 (4%) Rhabdomyosarcoma, Metastatic, Skeletal Muscle 1 (1%) Sarcoma, Metastatic, Uncertain Primary Site 1 (1%) Squamous Cell Carcinoma, Metastatic, Stomach, Forestomach 1 (1%) Spleen (98) (96) (98) Fibrosarcoma, Metastatic, Skeletal Muscle 1 (1%) Histiocytic Sarcoma 2 (2%) Sarcoma, Metastatic, Uncertain Primary Site 1 (1%) Thymus (98) (93) (99) Alveolar/Bronchiolar Carcinoma, Metastatic, Lung 1 (1%) Fibrosarcoma, Metastatic, Skin 1 (1%) Fibrosarcoma, Metastatic, Skeletal Muscle 1 (1%) Hepatocellular Carcinoma, Metastatic, Liver 1 (1%) Hepatocholangiocarcinoma, Metastatic, Liver 1 (1%) Thymoma Benign 1 (1%) 1 (1%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (93) (92) (91) Adenoma 1 (1%) Carcinoma 1 (1%) Skin (98) (98) (100) Fibrosarcoma 1 (1%) Sarcoma 1 (1%) Subcutaneous Tissue, Fibrosarcoma 1 (1%) 2 (2%) Subcutaneous Tissue, Fibrous Histiocytoma 1 (1%) Subcutaneous Tissue, Pinna, Fibrosarcoma 1 (1%) ____________________________________________________________________________________________________________________________________ Page 5 NTP Experiment-Test: 88066-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96 Route: VAGINAL Time: 18:44:40 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE UNTREATD VEHICLE 25% CONTROL CONTROL ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (100) (100) (100) Pelvis, Sarcoma 1 (1%) Skeletal Muscle (9) (10) (8) Fibrosarcoma, Metastatic, Skeletal Muscle 1 (11%) Hepatocholangiocarcinoma, Metastatic, Liver 1 (13%) Rhabdomyosarcoma 2 (22%) 2 (20%) 2 (25%) Sarcoma 1 (13%) Squamous Cell Carcinoma, Metastatic, Stomach, Forestomach 1 (11%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (100) (99) (100) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (100) (98) (100) Alveolar/Bronchiolar Adenoma 6 (6%) 7 (7%) 8 (8%) Alveolar/Bronchiolar Carcinoma 3 (3%) 3 (3%) 5 (5%) Carcinoma, Metastatic, Harderian Gland 1 (1%) Fibrosarcoma, Metastatic, Skin 1 (1%) Hepatocellular Carcinoma, Metastatic, Liver 4 (4%) 2 (2%) Hepatocholangiocarcinoma, Metastatic, Liver 2 (2%) Histiocytic Sarcoma 2 (2%) 1 (1%) Osteosarcoma, Metastatic, Tissue NOS 1 (1%) Sarcoma, Metastatic, Uncertain Primary Site 1 (1%) 1 (1%) Yolk Sac Carcinoma, Metastatic, Ovary 1 (1%) Nose (100) (100) (100) Carcinoma 1 (1%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Harderian Gland (5) (11) (6) Adenoma 4 (80%) 9 (82%) 4 (67%) Carcinoma 1 (20%) 2 (18%) 1 (17%) Zymbal's Gland (3) Carcinoma 1 (33%) ____________________________________________________________________________________________________________________________________ Page 6 NTP Experiment-Test: 88066-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96 Route: VAGINAL Time: 18:44:40 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE UNTREATD VEHICLE 25% CONTROL CONTROL ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (100) (98) (100) Adenoma 1 (1%) Histiocytic Sarcoma 1 (1%) Urinary Bladder (96) (96) (98) Histiocytic Sarcoma 1 (1%) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(100) *(100) *(100) Histiocytic Sarcoma 4 (4%) 2 (2%) 1 (1%) Lymphoma Malignant 13 (13%) 14 (14%) 18 (18%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 7 NTP Experiment-Test: 88066-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96 Route: VAGINAL Time: 18:44:40 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE UNTREATD VEHICLE 25% CONTROL CONTROL ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 78 82 88 Total Primary Neoplasms 145 160 161 Total Animals with Benign Neoplasms 67 72 69 Total Benign Neoplasms 103 109 102 Total Animals with Malignant Neoplasms 38 40 51 Total Malignant Neoplasms 42 51 58 Total Animals with Metastatic Neoplasms 11 7 4 Total Metastatic Neoplasm 33 13 15 Total Animals with Malignant Neoplasms 2 1 Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant 1 Total Uncertain Neoplasms 1 ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 8 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------