TDMS Study 88066-01 Pathology Tables
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
CORE STUDY
Facility: Arthur D. Little Life Science Laboratories
Chemical CAS #: 9002-89-5
Lock Date: 07/28/94
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 4| 4| 5| 5| 7| 6| 7| 7| 6| 7| 6| 4| 7| 7| 1| 7| 4| 7| 6| 7| 7|
DAY ON TEST | 3| 1| 5| 3| 0| 8| 9| 3| 2| 5| 3| 3| 5| 3| 4| 7| 2| 2| 1| 3| 4| 3| 6| 1| 2|
| 4| 8| 9| 1| 0| 3| 5| 8| 9| 7| 0| 0| 5| 1| 3| 6| 9| 9| 0| 1| 1| 0| 8| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + + I A A A A + A + + + + I + + + + + A + A + +|
Hyperplasia | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + A + + + + + + + + + + + + A + + A +|
Lymphoid Tissue, Hyperplasia | |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + A + A + + + + + + + + + + + + A + + A +|
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + A + A + + + + + + + + + + + + A + + A +|
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + A + A + + + + + + + + + + + + A + + A +|
Epithelium, Hyperplasia | |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + A + A + + + + + + + + + + + + A + + A +|
Peyer's Patch, Hyperplasia | 4 |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + A + A + + + + + + + + + + + + A + + A +|
Peyer's Patch, Hyperplasia, Lymphoid | 3 |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Basophilic Focus | |
Clear Cell Focus | X |
Depletion Glycogen | 2 2 2 1|
Eosinophilic Focus | |
Fibrosis | |
Hematopoietic Cell Proliferation | 2 3 1 2 2 |
Infarct | |
Inflammation | 4 |
Necrosis | |
Pigmentation, Hemosiderin | |
Vacuolization Cytoplasmic | 3 3 1 2 2 3 2 2 3 3 2|
Centrilobular, Dilatation | |
Centrilobular, Inflammation, Chronic | |
__________________________________________________________________________|
Mesentery | + + + + + + + + |
Inflammation, Chronic | 3 |
Necrosis | 4 4 4 4 4 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + A + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | |
Inflammation, Chronic | 2 |
Necrosis | |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 4| 4| 5| 5| 7| 6| 7| 7| 6| 7| 6| 4| 7| 7| 1| 7| 4| 7| 6| 7| 7|
DAY ON TEST | 3| 1| 5| 3| 0| 8| 9| 3| 2| 5| 3| 3| 5| 3| 4| 7| 2| 2| 1| 3| 4| 3| 6| 1| 2|
| 4| 8| 9| 1| 0| 3| 5| 8| 9| 7| 0| 0| 5| 1| 3| 6| 9| 9| 0| 1| 1| 0| 8| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Atrophy | |
Inflammation, Chronic | 2 1 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + A + + + + + + + + + + + + A + + A +|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + A + + + + + + + + + + + + A + + A +|
Hemorrhage | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Degeneration | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Degeneration | 2 1 2 1 2 2 2 2 1 2 1 2 2 2 2 1 1 2|
Inflammation, Chronic | 2 |
Valve, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Atrophy | 4 |
Hemorrhage | |
Capsule, Hyperplasia | |
Capsule, Inflammation, Chronic | |
Zona Glomerulosa, Hyperplasia | 2 |
Zona Reticularis, Hyperplasia | 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | 2 2 1 2 2 1 2 3 2 1 2 3 2|
Necrosis | |
__________________________________________________________________________|
Parathyroid Gland | I + I I + I I I + + + + + + + I I + + + I I + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + I + + + + + M + + + + + + + + + + + + I +|
Atrophy | |
Hemorrhage | 1 |
Pigmentation, Hemosiderin | 2 |
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia | 2 1 2 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 2 2 2 2 2 2 2 2 1 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 4| 4| 5| 5| 7| 6| 7| 7| 6| 7| 6| 4| 7| 7| 1| 7| 4| 7| 6| 7| 7|
DAY ON TEST | 3| 1| 5| 3| 0| 8| 9| 3| 2| 5| 3| 3| 5| 3| 4| 7| 2| 2| 1| 3| 4| 3| 6| 1| 2|
| 4| 8| 9| 1| 0| 3| 5| 8| 9| 7| 0| 0| 5| 1| 3| 6| 9| 9| 0| 1| 1| 0| 8| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + I + + + + + + + + + + + + + + + + + I + +|
Atrophy | 2 2 2 2 2 2 1 2 |
Hyperplasia | 2|
Inflammation, Chronic | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + I + + + + + + + + I + +|
Angiectasis | |
Atrophy | |
Cyst | 1 1 3 4 |
Hemorrhage | |
Inflammation, Acute | |
Necrosis | |
Thrombosis | 4 |
Periovarian Tissue, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Hemorrhage | |
Hydrometra | 4 |
Inflammation, Chronic Active | |
Inflammation | 3 |
Endometrium, Angiectasis | |
Endometrium, Hemorrhage | |
Endometrium, Hyperplasia, Cystic | 1 2 2 2 2 3 3 2 2 3 3 3 3 1 2 3 3 3 2 3 3 2 2|
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Depletion Cellular | |
Hyperplasia | 2 2 |
Myelofibrosis | 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + |
Hyperplasia | 2 |
Bronchial, Hemorrhage | |
Mediastinal, Hemorrhage | |
Mediastinal, Hyperplasia | |
Renal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + I + + + + + + + + +|
Atrophy | 2 1 2 1 2 |
Hyperplasia, Lymphoid | 4 |
Hyperplasia | 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 4| 4| 5| 5| 7| 6| 7| 7| 6| 7| 6| 4| 7| 7| 1| 7| 4| 7| 6| 7| 7|
DAY ON TEST | 3| 1| 5| 3| 0| 8| 9| 3| 2| 5| 3| 3| 5| 3| 4| 7| 2| 2| 1| 3| 4| 3| 6| 1| 2|
| 4| 8| 9| 1| 0| 3| 5| 8| 9| 7| 0| 0| 5| 1| 3| 6| 9| 9| 0| 1| 1| 0| 8| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Necrosis | 3 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + I + + + A + + + + + + + + + + + + + + A + + + +|
Atrophy | 2 3 1 2 |
Hemorrhage | 2 |
Hyperplasia | 2 |
Inflammation, Chronic | |
Necrosis | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 3 2 3 3 2 2 3 2 2 2 |
Necrosis | |
Pigmentation, Hemosiderin | 2 2 2 2 2 2|
Thrombosis | |
Lymphoid Follicle, Atrophy | 2 |
Lymphoid Follicle, Hyperplasia | 2 2 3 3 2 1 4 4 4 1|
Red Pulp, Atrophy | 2 2 |
__________________________________________________________________________|
Thymus | + + + + I + + + + + + + + + I + + + + + + + + + +|
Atrophy | 4 2 3 4 3 2 4 2 3 1 2 4 2 3 3|
Hemorrhage | |
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + I I + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + A +|
Edema | |
Inflammation, Chronic | |
Hair Follicle, Atrophy | 2 |
Vulva, Ulcer | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
Osteoporosis | |
__________________________________________________________________________|
Skeletal Muscle | + + |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | |
Inflammation, Chronic | |
Thalamus, Mineralization | 2 1 2 2 2 2 1 2 2 1 |
__________________________________________________________________________|
Peripheral Nerve | + |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 4| 4| 5| 5| 7| 6| 7| 7| 6| 7| 6| 4| 7| 7| 1| 7| 4| 7| 6| 7| 7|
DAY ON TEST | 3| 1| 5| 3| 0| 8| 9| 3| 2| 5| 3| 3| 5| 3| 4| 7| 2| 2| 1| 3| 4| 3| 6| 1| 2|
| 4| 8| 9| 1| 0| 3| 5| 8| 9| 7| 0| 0| 5| 1| 3| 6| 9| 9| 0| 1| 1| 0| 8| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 2 |
Hemorrhage | 3 1 |
Infiltration Cellular | |
Inflammation, Acute | 3 1 1 |
Inflammation, Chronic | 2 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Respiratory Epithelium, Inflammation | 2 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Atrophy | |
Cornea, Inflammation, Chronic | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 2 |
Inflammation | 2 |
Metaplasia, Osseous | |
Mineralization | |
Nephropathy | 1 2 1 2 1 1 1 1 1 1 2 2 1 1 2 1 1 2 1 1|
Glomerulus, Amyloid Deposition | |
__________________________________________________________________________|
Urinary Bladder | + + + + + I + + + + + + I + + + + + + + + + + A +|
Serosa, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 6| 7| 1| 7| 3| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 5| 5|
DAY ON TEST | 4| 2| 7| 0| 5| 3| 3| 0| 3| 2| 3| 3| 9| 9| 2| 3| 2| 3| 3| 2| 2| 2| 3| 8| 1|
| 0| 1| 5| 9| 0| 1| 0| 6| 1| 9| 0| 0| 6| 5| 9| 9| 5| 0| 1| 9| 9| 9| 0| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + A + + + + + A + + + + + + + + + + A|
Hyperplasia | 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + + A + + + + + + + + + + +|
Lymphoid Tissue, Hyperplasia | |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + + + + A + + + + + + + + + + +|
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + + A + + + + + + + + + + A|
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + + + A + + + + + + + + + + A|
Epithelium, Hyperplasia | 2 |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + + + A + + + + + + + + + + A|
Peyer's Patch, Hyperplasia | 4 |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + + A + + + + + + + + + + A|
Peyer's Patch, Hyperplasia, Lymphoid | |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Liver | + + + + + + + A + + + + + + + + + + + + + + + + +|
Atrophy | |
Basophilic Focus | X |
Clear Cell Focus | |
Depletion Glycogen | 2 2 |
Eosinophilic Focus | X X |
Fibrosis | |
Hematopoietic Cell Proliferation | 2 2 2 4 2 2 |
Infarct | |
Inflammation | |
Necrosis | 2 4 |
Pigmentation, Hemosiderin | |
Vacuolization Cytoplasmic | 2 2 2 3 3 3 2 3 2 2 3 3 2|
Centrilobular, Dilatation | 2 |
Centrilobular, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Mesentery | + + + + |
Inflammation, Chronic | |
Necrosis | 4 4 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + A + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 |
Hyperplasia | 2 |
Inflammation, Chronic | 2 1 2 1 |
Necrosis | 4 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 6| 7| 1| 7| 3| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 5| 5|
DAY ON TEST | 4| 2| 7| 0| 5| 3| 3| 0| 3| 2| 3| 3| 9| 9| 2| 3| 2| 3| 3| 2| 2| 2| 3| 8| 1|
| 0| 1| 5| 9| 0| 1| 0| 6| 1| 9| 0| 0| 6| 5| 9| 9| 5| 0| 1| 9| 9| 9| 0| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Atrophy | |
Inflammation, Chronic | 3 2 2 2 2 3 2 2 3 2 2 2|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + A + + + + + + + + + + A|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + A + + + + + A + + + + + + + + + + A|
Hemorrhage | 1 |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Degeneration | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Degeneration | 2 2 1 2 2 2 1 2 1 2 3 2 1 1 1 2 3 2 2 2 1 |
Inflammation, Chronic | |
Valve, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Atrophy | |
Hemorrhage | 2 |
Capsule, Hyperplasia | |
Capsule, Inflammation, Chronic | |
Zona Glomerulosa, Hyperplasia | 2 1 2 2 2 2 |
Zona Reticularis, Hyperplasia | 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + A + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | 1 1 1 2 1 2 2 1 2 2 2 1 3 2 2 3 2|
Necrosis | 4 |
__________________________________________________________________________|
Parathyroid Gland | + + I + I + I I I + I + + + + I I + + I + + + + I|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M M + + + + + + + + + + M + + +|
Atrophy | |
Hemorrhage | |
Pigmentation, Hemosiderin | |
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Hyperplasia | 2 4 2 2 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 2 1 2 2 3 2 2 2 4 2 3 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 6| 7| 1| 7| 3| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 5| 5|
DAY ON TEST | 4| 2| 7| 0| 5| 3| 3| 0| 3| 2| 3| 3| 9| 9| 2| 3| 2| 3| 3| 2| 2| 2| 3| 8| 1|
| 0| 1| 5| 9| 0| 1| 0| 6| 1| 9| 0| 0| 6| 5| 9| 9| 5| 0| 1| 9| 9| 9| 0| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | I + + + + + + + I + I + + I + + + + + + + + + + M|
Atrophy | 2 1 2 2 1 2 2 2 1 |
Hyperplasia | 1 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Ovary | + + + + + + + + + M + + + M + + + + + + + + + + +|
Angiectasis | |
Atrophy | 2 |
Cyst | 2 4 1 2 1 |
Hemorrhage | |
Inflammation, Acute | |
Necrosis | |
Thrombosis | |
Periovarian Tissue, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 |
Hemorrhage | |
Hydrometra | 4 4 3 |
Inflammation, Chronic Active | |
Inflammation | |
Endometrium, Angiectasis | |
Endometrium, Hemorrhage | |
Endometrium, Hyperplasia, Cystic | 2 2 4 2 2 4 1 2 2 2 3 1 4 3 3 3 3 4 4 4 4 3 2|
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Depletion Cellular | |
Hyperplasia | 2 2 2 |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + |
Hyperplasia | |
Bronchial, Hemorrhage | |
Mediastinal, Hemorrhage | |
Mediastinal, Hyperplasia | |
Renal, Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + I I + + + + + + + + + + + + + + + + + I + I +|
Atrophy | 3 2|
Hyperplasia, Lymphoid | |
Hyperplasia | 2 2 3 2 |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 6| 7| 1| 7| 3| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 5| 5|
DAY ON TEST | 4| 2| 7| 0| 5| 3| 3| 0| 3| 2| 3| 3| 9| 9| 2| 3| 2| 3| 3| 2| 2| 2| 3| 8| 1|
| 0| 1| 5| 9| 0| 1| 0| 6| 1| 9| 0| 0| 6| 5| 9| 9| 5| 0| 1| 9| 9| 9| 0| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Necrosis | 4 |
Pigmentation, Hemosiderin | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + A + + + + + A + + + + + + + + + + A|
Atrophy | 2 |
Hemorrhage | |
Hyperplasia | 2 2 1 |
Inflammation, Chronic | 2 |
Necrosis | |
__________________________________________________________________________|
Spleen | + + + + + + + A + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 3 2 3 2 3 4 2 |
Necrosis | 3 |
Pigmentation, Hemosiderin | 2 1 3 2 2 2 2 2 1 2 2 |
Thrombosis | 3 |
Lymphoid Follicle, Atrophy | 2 3 2|
Lymphoid Follicle, Hyperplasia | 2 3 4 3 3 2 3 2 3 3 3 4 3 3 2 |
Red Pulp, Atrophy | 2 2 2|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 4 4 2 2 4 1 2 4 3 1 3 2 1 1 1 3 4|
Hemorrhage | |
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + I + + + + + + + + + + + A + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + A + + + + + + + + + + +|
Edema | |
Inflammation, Chronic | |
Hair Follicle, Atrophy | 3 |
Vulva, Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
Osteoporosis | |
__________________________________________________________________________|
Skeletal Muscle | + |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | |
Inflammation, Chronic | |
Thalamus, Mineralization | 2 1 2 2 2 1 2 2 2 2 2 1|
__________________________________________________________________________|
Peripheral Nerve | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 6| 7| 1| 7| 3| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 5| 5|
DAY ON TEST | 4| 2| 7| 0| 5| 3| 3| 0| 3| 2| 3| 3| 9| 9| 2| 3| 2| 3| 3| 2| 2| 2| 3| 8| 1|
| 0| 1| 5| 9| 0| 1| 0| 6| 1| 9| 0| 0| 6| 5| 9| 9| 5| 0| 1| 9| 9| 9| 0| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 3 2 1|
Hemorrhage | 2 |
Infiltration Cellular | |
Inflammation, Acute | |
Inflammation, Chronic | 2 2 2 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Respiratory Epithelium, Inflammation | 1 1 1 2 1 1 1 1 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Atrophy | |
Cornea, Inflammation, Chronic | 2 1 |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Inflammation | |
Metaplasia, Osseous | 2 |
Mineralization | |
Nephropathy | 1 2 2 2 2 2 1 1 1 2 1 2 1 2 2 1 2 2 2 1 2 |
Glomerulus, Amyloid Deposition | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + M + + + + + + +|
Serosa, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 3| 7| 3| 4| 7|
DAY ON TEST | 2| 3| 3| 1| 9| 3| 3| 9| 2| 4| 2| 2| 3| 3| 5| 5| 3| 3| 8| 6| 6| 2| 5| 7| 2|
| 9| 1| 0| 1| 2| 1| 0| 0| 9| 6| 5| 9| 1| 0| 5| 2| 0| 0| 2| 6| 5| 9| 7| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + I + + + + + + + + I + + + + A + + A I +|
Hyperplasia | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + A + +|
Lymphoid Tissue, Hyperplasia | 2 |
Serosa, Inflammation, Chronic | 4 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + A + +|
Serosa, Inflammation, Chronic | 4 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + A + +|
Serosa, Inflammation, Chronic | 4 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + A + +|
Epithelium, Hyperplasia | |
Serosa, Inflammation, Chronic | 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + A + +|
Peyer's Patch, Hyperplasia | |
Serosa, Inflammation, Chronic | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
Serosa, Inflammation, Chronic | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Basophilic Focus | X |
Clear Cell Focus | |
Depletion Glycogen | 2 1 2 2 2|
Eosinophilic Focus | |
Fibrosis | 1 |
Hematopoietic Cell Proliferation | 3 4 1 2 1 1 2|
Infarct | |
Inflammation | 2 2 |
Necrosis | |
Pigmentation, Hemosiderin | 1 |
Vacuolization Cytoplasmic | 2 2 1 2 2 2 |
Centrilobular, Dilatation | |
Centrilobular, Inflammation, Chronic | |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + |
Inflammation, Chronic | 4 2 |
Necrosis | 4 4 4 4 4 4 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + A + +|
Atrophy | 2 2 2 2 2 |
Hyperplasia | |
Inflammation, Chronic | 4 2 2 2 2 2 2 2 |
Necrosis | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + I + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 3| 7| 3| 4| 7|
DAY ON TEST | 2| 3| 3| 1| 9| 3| 3| 9| 2| 4| 2| 2| 3| 3| 5| 5| 3| 3| 8| 6| 6| 2| 5| 7| 2|
| 9| 1| 0| 1| 2| 1| 0| 0| 9| 6| 5| 9| 1| 0| 5| 2| 0| 0| 2| 6| 5| 9| 7| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Atrophy | 2 2 1 |
Inflammation, Chronic | 2 2 3 2 1 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + A + +|
Epithelium, Hyperplasia | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + A + +|
Hemorrhage | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Degeneration | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 |
Degeneration | 1 1 3 3 2 2 2 2 2 3 1 2 2 3 2 1 2 2 2 2 3 1 2|
Inflammation, Chronic | |
Valve, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Atrophy | |
Hemorrhage | |
Capsule, Hyperplasia | 2 2 3 |
Capsule, Inflammation, Chronic | 4 |
Zona Glomerulosa, Hyperplasia | 3 2 3 |
Zona Reticularis, Hyperplasia | 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + I + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + A + +|
Atrophy | 4 3 |
Hyperplasia | 1 3 2 1 2 1 2 2 3 3 3 2 3 3 2 4 3 3 3 3 2|
Necrosis | |
__________________________________________________________________________|
Parathyroid Gland | I + + I + + + + + + I + + I + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + + + + + + + + + + + + M + A M +|
Atrophy | |
Hemorrhage | 3 |
Pigmentation, Hemosiderin | |
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia | 4 1 2 3 3 4 2 3 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 2 2 1 3 1 2 2 3 2 3 2 3 2 1 2 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 3| 7| 3| 4| 7|
DAY ON TEST | 2| 3| 3| 1| 9| 3| 3| 9| 2| 4| 2| 2| 3| 3| 5| 5| 3| 3| 8| 6| 6| 2| 5| 7| 2|
| 9| 1| 0| 1| 2| 1| 0| 0| 9| 6| 5| 9| 1| 0| 5| 2| 0| 0| 2| 6| 5| 9| 7| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + M + I + + + + +|
Atrophy | 2 2 2 2 2 2 1 |
Hyperplasia | 2 |
Inflammation, Chronic | 4 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + A + +|
Angiectasis | 3 |
Atrophy | |
Cyst | 1 2 4 |
Hemorrhage | 1 |
Inflammation, Acute | |
Necrosis | 3 |
Thrombosis | 4 |
Periovarian Tissue, Inflammation, | |
Chronic | 2 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Hemorrhage | 3 |
Hydrometra | 4|
Inflammation, Chronic Active | 2 |
Inflammation | 1 |
Endometrium, Angiectasis | |
Endometrium, Hemorrhage | 3 |
Endometrium, Hyperplasia, Cystic | 3 4 3 4 3 3 3 2 4 3 2 3 4 4 3 2 4 4 4 4 2 4 3 4|
Serosa, Inflammation, Chronic | 4 2 |
__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Depletion Cellular | |
Hyperplasia | 3 3 2 2|
Myelofibrosis | 2 2 2 2 1 |
__________________________________________________________________________|
Lymph Node | + + + |
Hyperplasia | |
Bronchial, Hemorrhage | 2 |
Mediastinal, Hemorrhage | 3 |
Mediastinal, Hyperplasia | 3 |
Renal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + I + + + I + + + + + M + + + +|
Atrophy | 2 2 2 |
Hyperplasia, Lymphoid | |
Hyperplasia | 4 2 3 2 |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 3| 7| 3| 4| 7|
DAY ON TEST | 2| 3| 3| 1| 9| 3| 3| 9| 2| 4| 2| 2| 3| 3| 5| 5| 3| 3| 8| 6| 6| 2| 5| 7| 2|
| 9| 1| 0| 1| 2| 1| 0| 0| 9| 6| 5| 9| 1| 0| 5| 2| 0| 0| 2| 6| 5| 9| 7| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Necrosis | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + I + + + + + + + A + +|
Atrophy | 2 1 2 3 2 3 |
Hemorrhage | |
Hyperplasia | 4 |
Inflammation, Chronic | 4 |
Necrosis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + A + +|
Hematopoietic Cell Proliferation | 4 2 3 3 4 2 2 2 2 4 2 3 3 1 2 2 2 |
Necrosis | |
Pigmentation, Hemosiderin | 2 2 2 2 2 1 2 2 2 2 1 2 1|
Thrombosis | |
Lymphoid Follicle, Atrophy | 2 |
Lymphoid Follicle, Hyperplasia | 3 3 3 3 2 2 2 3 3 3 3 2 2 |
Red Pulp, Atrophy | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 2 2 1 3 4 3 4 3 3 1 4 2 4 |
Hemorrhage | |
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + I + I + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 4 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Inflammation, Chronic | 4 |
Hair Follicle, Atrophy | |
Vulva, Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 1 |
Osteoporosis | 4 |
__________________________________________________________________________|
Skeletal Muscle | + + + + |
Inflammation, Chronic | 2 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 3 |
Inflammation, Chronic | |
Thalamus, Mineralization | 2 2 2 2 2 2 1 2 2 2 1 2 2|
__________________________________________________________________________|
Peripheral Nerve | + + |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 3| 7| 3| 4| 7|
DAY ON TEST | 2| 3| 3| 1| 9| 3| 3| 9| 2| 4| 2| 2| 3| 3| 5| 5| 3| 3| 8| 6| 6| 2| 5| 7| 2|
| 9| 1| 0| 1| 2| 1| 0| 0| 9| 6| 5| 9| 1| 0| 5| 2| 0| 0| 2| 6| 5| 9| 7| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hemorrhage | 2 3 1 |
Infiltration Cellular | 3 |
Inflammation, Acute | |
Inflammation, Chronic | 2 2 2 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Respiratory Epithelium, Inflammation | 1 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Atrophy | 4 |
Cornea, Inflammation, Chronic | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Inflammation | |
Metaplasia, Osseous | |
Mineralization | 2 |
Nephropathy | 1 2 2 2 2 1 2 2 2 1 2 2 1 1 3 3 1 2 2 2 2 2 1 2|
Glomerulus, Amyloid Deposition | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Chronic | 4 |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
__________________________________________________________________________________________________________________________________
| 0| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 1| 7| 7| 7| 7| |
DAY ON TEST | 6| 2| 3| 3| 0| 2| 3| 0| 1| 8| 3| 2| 8| 3| 3| 2| 5| 7| 6| 3| 6| 3| 0| 2| 3| |
| 7| 9| 0| 1| 4| 9| 0| 3| 0| 6| 0| 5| 2| 0| 1| 9| 7| 5| 8| 0| 8| 1| 4| 9| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
UNTREATD | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Gallbladder | + + I + + + + A A + + + + + + + A + A + A + + + +| 76 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + + + +| 92 |
Lymphoid Tissue, Hyperplasia | | 1 2.0|
Serosa, Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + + + + + A + + + + + + + + + + + A + + + +| 89 |
Serosa, Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + A + + + + + + + + + + + A + + + +| 88 |
Serosa, Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + + A + + + + + + + + + + + A + + + +| 88 |
Epithelium, Hyperplasia | 2 | 2 2.0|
Serosa, Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + A + + + +| 89 |
Peyer's Patch, Hyperplasia | | 2 4.0|
Serosa, Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + A + + + + + + + + + + + A + + + +| 88 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 3.0|
Serosa, Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
Atrophy | | 1 2.0|
Basophilic Focus | | 2 |
Clear Cell Focus | | 1 |
Depletion Glycogen | 2 2 1 2 3 3 2 2 2| 20 2.0|
Eosinophilic Focus | | 2 |
Fibrosis | | 1 1.0|
Hematopoietic Cell Proliferation | 2 2 2 1 1 | 23 2.0|
Infarct | 4 | 1 4.0|
Inflammation | | 3 2.7|
Necrosis | 2 | 3 2.7|
Pigmentation, Hemosiderin | | 1 1.0|
Vacuolization Cytoplasmic | 3 3 3 2 2 3 2 2 | 38 2.3|
Centrilobular, Dilatation | | 1 2.0|
Centrilobular, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + | 33 |
Inflammation, Chronic | | 3 3.0|
Necrosis | 4 4 4 4 4 4 4 4 | 27 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 97 |
Atrophy | 2 3 2 | 11 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
__________________________________________________________________________________________________________________________________
| 0| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 1| 7| 7| 7| 7| |
DAY ON TEST | 6| 2| 3| 3| 0| 2| 3| 0| 1| 8| 3| 2| 8| 3| 3| 2| 5| 7| 6| 3| 6| 3| 0| 2| 3| |
| 7| 9| 0| 1| 4| 9| 0| 3| 0| 6| 0| 5| 2| 0| 1| 9| 7| 5| 8| 0| 8| 1| 4| 9| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
UNTREATD | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia | | 1 2.0|
Inflammation, Chronic | 1 1 2 2 1 | 18 1.8|
Necrosis | | 1 4.0|
Vacuolization Cytoplasmic | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
Atrophy | 1 2 3 | 6 1.8|
Inflammation, Chronic | 2 3 1 2 2 2 2 2 2 2 2 1 2 1 2 1 1| 52 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 94 |
Epithelium, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 93 |
Hemorrhage | | 1 1.0|
Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Aorta, Degeneration | | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Cardiomyopathy | 3 | 2 3.0|
Degeneration | 2 2 2 2 2 1 2 2 1 3 2 2 2 3 1 2 2 2 2 2 2| 83 1.9|
Inflammation, Chronic | | 1 2.0|
Valve, Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Accessory Adrenal Cortical Nodule | | 1 1.0|
Atrophy | | 1 4.0|
Hemorrhage | | 1 2.0|
Capsule, Hyperplasia | 1 | 4 2.0|
Capsule, Inflammation, Chronic | 2 | 2 3.0|
Zona Glomerulosa, Hyperplasia | 2 | 11 2.1|
Zona Reticularis, Hyperplasia | | 6 1.7|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + A + + + + + +| 97 |
Atrophy | | 2 3.5|
Hyperplasia | 4 1 2 3 2 2 2 3 2 4 3 2 1 3 2 1 1 2 3| 70 2.1|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + I + I I I + I + I I I I + + I I + + I I I I I I| 59 |
Hyperplasia | 1 | 2 1.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + M + M + + + + + +| 88 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
__________________________________________________________________________________________________________________________________
| 0| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 1| 7| 7| 7| 7| |
DAY ON TEST | 6| 2| 3| 3| 0| 2| 3| 0| 1| 8| 3| 2| 8| 3| 3| 2| 5| 7| 6| 3| 6| 3| 0| 2| 3| |
| 7| 9| 0| 1| 4| 9| 0| 3| 0| 6| 0| 5| 2| 0| 1| 9| 7| 5| 8| 0| 8| 1| 4| 9| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
UNTREATD | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Atrophy | 2 | 1 2.0|
Hemorrhage | | 2 2.0|
Pigmentation, Hemosiderin | | 1 2.0|
Pars Distalis, Angiectasis | | 1 3.0|
Pars Distalis, Hyperplasia | 3 3 1 3 4 1 4 4 | 27 2.6|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Follicular Cell, Hyperplasia | 3 1 2 2 2 1 2 2 3 2 3 2 1 2 | 57 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + I + + + + + + + I + + + + + + + + + + + + + +| 89 |
Atrophy | 2 2 2 1 1 | 29 1.8|
Hyperplasia | | 4 1.8|
Inflammation, Chronic | | 2 4.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 95 |
Angiectasis | | 1 3.0|
Atrophy | | 1 2.0|
Cyst | 2 | 13 2.2|
Hemorrhage | 2 | 2 1.5|
Inflammation, Acute | 4 | 1 4.0|
Necrosis | | 1 3.0|
Thrombosis | | 2 4.0|
Periovarian Tissue, Inflammation, | | |
Chronic | | 2 2.5|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Amyloid Deposition | | 1 3.0|
Hemorrhage | 3 | 2 3.0|
Hydrometra | 4 4 | 7 3.9|
Inflammation, Chronic Active | | 1 2.0|
Inflammation | | 2 2.0|
Endometrium, Angiectasis | 2 | 1 2.0|
Endometrium, Hemorrhage | | 1 3.0|
Endometrium, Hyperplasia, Cystic | 4 1 3 2 4 4 4 3 3 3 3 4 4 4 2 3 3 3 3 2| 90 2.9|
Serosa, Inflammation, Chronic | | 2 3.0|
__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +| 97 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
__________________________________________________________________________________________________________________________________
| 0| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 1| 7| 7| 7| 7| |
DAY ON TEST | 6| 2| 3| 3| 0| 2| 3| 0| 1| 8| 3| 2| 8| 3| 3| 2| 5| 7| 6| 3| 6| 3| 0| 2| 3| |
| 7| 9| 0| 1| 4| 9| 0| 3| 0| 6| 0| 5| 2| 0| 1| 9| 7| 5| 8| 0| 8| 1| 4| 9| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
UNTREATD | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Amyloid Deposition | 2 | 1 2.0|
Depletion Cellular | 2 | 1 2.0|
Hyperplasia | 2 2 2 | 12 2.2|
Myelofibrosis | 3 1 1 3 1 1 3 2 2 1 2 | 19 1.8|
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 15 |
Hyperplasia | 3 | 2 2.5|
Bronchial, Hemorrhage | | 1 2.0|
Mediastinal, Hemorrhage | | 1 3.0|
Mediastinal, Hyperplasia | | 1 3.0|
Renal, Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 92 |
Atrophy | 4 2 | 12 2.1|
Hyperplasia, Lymphoid | | 1 4.0|
Hyperplasia | 2 2 2 2 4| 16 2.4|
Necrosis | | 2 3.5|
Pigmentation, Hemosiderin | 2 | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + I I + + + + + + + + + + + +| 90 |
Atrophy | 2 | 12 2.1|
Hemorrhage | | 1 2.0|
Hyperplasia | 2 3| 7 2.3|
Inflammation, Chronic | | 2 3.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 98 |
Hematopoietic Cell Proliferation | 3 3 4 2 2 3 3 2 3 3 2 2 2 2 | 52 2.5|
Necrosis | 2 | 2 2.5|
Pigmentation, Hemosiderin | 2 2 1 2 2 2 2 3 2 1 2| 41 1.9|
Thrombosis | | 1 3.0|
Lymphoid Follicle, Atrophy | 1 2 2 | 8 2.0|
Lymphoid Follicle, Hyperplasia | 3 3 3 3 2 3 2 3 3 2 1 3 3 3| 52 2.7|
Red Pulp, Atrophy | 2 | 7 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 98 |
Atrophy | 2 4 4 3 3 1 1 3 1 2 1 3 3 2 1 4 2 1| 66 2.5|
Hemorrhage | 2 2 | 2 2.0|
Necrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + I + + + + + + + + + +| 93 |
Hyperplasia | 3 2 | 8 2.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
__________________________________________________________________________________________________________________________________
| 0| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 1| 7| 7| 7| 7| |
DAY ON TEST | 6| 2| 3| 3| 0| 2| 3| 0| 1| 8| 3| 2| 8| 3| 3| 2| 5| 7| 6| 3| 6| 3| 0| 2| 3| |
| 7| 9| 0| 1| 4| 9| 0| 3| 0| 6| 0| 5| 2| 0| 1| 9| 7| 5| 8| 0| 8| 1| 4| 9| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
UNTREATD | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 98 |
Edema | | 1 2.0|
Inflammation, Chronic | | 1 4.0|
Hair Follicle, Atrophy | | 2 2.5|
Vulva, Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Hyperostosis | | 1 1.0|
Osteoporosis | | 1 4.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 9 |
Inflammation, Chronic | 1 | 3 1.7|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Hydrocephalus | 2 | 2 2.5|
Inflammation, Chronic | 2| 1 2.0|
Thalamus, Mineralization | 2 1 2 2 2 2 2 2 2 2 2 | 46 1.8|
__________________________________________________________________________|____________|
Peripheral Nerve | | 3 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Edema | 2 2 2 | 9 2.1|
Hemorrhage | 2 2 | 8 2.0|
Infiltration Cellular | | 1 3.0|
Inflammation, Acute | 1 1 2 1 | 7 1.4|
Inflammation, Chronic | 2 2 | 9 2.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Hemorrhage | 3| 1 3.0|
Respiratory Epithelium, Inflammation | 1 1 1 1 1 1 | 22 1.1|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 4 |
Atrophy | | 1 4.0|
Cornea, Inflammation, Chronic | 1 | 3 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
__________________________________________________________________________________________________________________________________
| 0| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 1| 7| 7| 7| 7| |
DAY ON TEST | 6| 2| 3| 3| 0| 2| 3| 0| 1| 8| 3| 2| 8| 3| 3| 2| 5| 7| 6| 3| 6| 3| 0| 2| 3| |
| 7| 9| 0| 1| 4| 9| 0| 3| 0| 6| 0| 5| 2| 0| 1| 9| 7| 5| 8| 0| 8| 1| 4| 9| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
UNTREATD | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Hydronephrosis | | 1 2.0|
Inflammation | | 1 2.0|
Metaplasia, Osseous | | 1 2.0|
Mineralization | | 1 2.0|
Nephropathy | 1 2 1 2 1 2 1 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2| 88 1.6|
Glomerulus, Amyloid Deposition | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 96 |
Serosa, Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 6| 7| 6| 6| 7| 6| 5| 7| 3| 6| 6| 6| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 5| 9| 1| 1| 8| 2| 1| 5| 7| 7| 0| 3| 3| 2| 4| 6| 2| 3| 3| 1| 3| 3| 3|
| 9| 0| 8| 0| 7| 3| 8| 9| 3| 4| 5| 5| 5| 0| 1| 2| 6| 2| 9| 1| 1| 1| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + A A + A + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + + + + + + + + + + A + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + A + + + + + + + + + + A + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + A + + + + + + + + + + A + + + + + + +|
Inflammation, Chronic | 2 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + A + + + + + + + + + + A + + + + + + +|
Inflammation, Chronic | 2 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Basophilic Focus | |
Clear Cell Focus | X X X |
Depletion Glycogen | 2 1 1 2 2 2 2 2 |
Eosinophilic Focus | X |
Fibrosis | |
Hematopoietic Cell Proliferation | 2 2 1 2 3 2 2 2 1 |
Inflammation | |
Necrosis | |
Pigmentation, Hemosiderin | |
Vacuolization Cytoplasmic | 2 3 3 2 2 2 2 2 2 2 2 3 |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Mesentery | + + + + + |
Inflammation, Chronic | |
Necrosis | 4 4 4 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 1|
Hyperplasia, Lymphoid | |
Inflammation, Chronic | 2 2 2 1 1 1 2 1 1 1 2 2 |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + M + + + + + + + + + + + + + + + + + +|
Atrophy | |
Inflammation, Chronic | 2 2 2 2 2 2 3 1 2 2 2 1 2 2 2 1 4|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + A + + + + + + + + + + A + + + + + + +|
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + A + + + + + + + + + + A + + + + + + +|
Ectopic Liver | |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 6| 7| 6| 6| 7| 6| 5| 7| 3| 6| 6| 6| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 5| 9| 1| 1| 8| 2| 1| 5| 7| 7| 0| 3| 3| 2| 4| 6| 2| 3| 3| 1| 3| 3| 3|
| 9| 0| 8| 0| 7| 3| 8| 9| 3| 4| 5| 5| 5| 0| 1| 2| 6| 2| 9| 1| 1| 1| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Epithelium, Atrophy | |
Epithelium, Hyperplasia | |
Epithelium, Metaplasia, Squamous | |
Epithelium, Mineralization | |
Serosa, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Degeneration | 3 2 2 2 3 2 2 2 2 1 2 2 2 2 2 2 1 2 2 2 2 2|
Inflammation, Chronic | |
Mineralization | |
Thrombosis | |
Epicardium, Hyperplasia, Lymphoid | |
Epicardium, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Angiectasis | 3 |
Hematopoietic Cell Proliferation | |
Vacuolization Cytoplasmic | |
Capsule, Hyperplasia | 3 2 |
Zona Glomerulosa, Atrophy | |
Zona Glomerulosa, Hyperplasia | 2 2 |
Zona Reticularis, Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 3 2 1 2 3 1 1 2 1 2 3 3 2 2 2 4 3 4 1 3|
Infiltration Cellular, Lymphocyte | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + I + + + + I I + + I + + + I + I + I I I + + +|
Cyst | |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + + + + + + M I + + + + + +|
Hemorrhage | |
Pars Distalis, Hyperplasia | 2 2 2 2 3 1 2 |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 3 2 3 2 2 1 3 2 2 3 2 3 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 6| 7| 6| 6| 7| 6| 5| 7| 3| 6| 6| 6| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 5| 9| 1| 1| 8| 2| 1| 5| 7| 7| 0| 3| 3| 2| 4| 6| 2| 3| 3| 1| 3| 3| 3|
| 9| 0| 8| 0| 7| 3| 8| 9| 3| 4| 5| 5| 5| 0| 1| 2| 6| 2| 9| 1| 1| 1| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + I + + I + + + + + I + + + + + + +|
Atrophy | 2 2 2 3 2 2 1 1|
Hyperplasia | 2 2 1 |
Inflammation, Chronic | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 3 4 2 |
Hemorrhage | |
Hyperplasia, Lymphoid | |
Inflammation, Chronic | 4 |
Necrosis | 4 4 |
Thrombosis | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diestrus | |
Hydrometra | 4 |
Inflammation, Chronic Active | |
Endometrium, Angiectasis | 3 |
Endometrium, Hyperplasia, Cystic | 3 2 4 3 3 3 3 2 2 4 3 4 4 4 3 3 3 4 4 4 3 3 4 4|
__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diestrus | |
Inflammation, Acute | 3 |
Inflammation, Chronic | |
Epithelium, Hyperplasia | |
Epithelium, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 2|
Myelofibrosis | 1 2 2|
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Lymph Node | + + + + + +|
Ectasia | 4 |
Hyperplasia | 3 |
Infiltration Cellular, Plasma Cell | |
Iliac, Hyperplasia | 3 |
Iliac, Inflammation, Acute | |
Mediastinal, Hyperplasia | 4 |
Renal, Inflammation, Acute | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hemorrhage | |
Hyperplasia | 2 1 2 2 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + A + I + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 6| 7| 6| 6| 7| 6| 5| 7| 3| 6| 6| 6| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 5| 9| 1| 1| 8| 2| 1| 5| 7| 7| 0| 3| 3| 2| 4| 6| 2| 3| 3| 1| 3| 3| 3|
| 9| 0| 8| 0| 7| 3| 8| 9| 3| 4| 5| 5| 5| 0| 1| 2| 6| 2| 9| 1| 1| 1| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Atrophy | 1 2 |
Hyperplasia | 2 2 |
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 3 3 3 3 3 3 2 3 4 3 3 4 2 3 |
Pigmentation, Hemosiderin | 2 2 2 1 2 1 2 2 3 2 2 2 1 |
Capsule, Inflammation, Chronic | |
Lymphoid Follicle, Atrophy | 2 |
Lymphoid Follicle, Hyperplasia | 2 3 3 3 3 3 4 2 3 3 3 3 2 3 3 3 2 3 |
Red Pulp, Atrophy | 2 |
__________________________________________________________________________|
Thymus | + + + + + + A + + + + + + + + + + + + + + + + + +|
Atrophy | 4 1 1 3 4 2 3 4 3 1 1 3 2 3 2 4 1 4 2 2 4|
Hyperplasia, Lymphoid | |
Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + I + + + + + + +|
Hyperplasia | 2 2 2 1 |
Inflammation, Chronic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Inflammation, Chronic | 3 2 |
Hair Follicle, Atrophy | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + |
Degeneration | |
Metaplasia, Osseous | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 1 2 |
Inflammation, Chronic | |
Meninges, Infiltration Cellular, | |
Lymphocyte | |
Thalamus, Mineralization | 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Peripheral Nerve | + + |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 1 3 1 |
Hemorrhage | 1 3 1 |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 6| 7| 6| 6| 7| 6| 5| 7| 3| 6| 6| 6| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 5| 9| 1| 1| 8| 2| 1| 5| 7| 7| 0| 3| 3| 2| 4| 6| 2| 3| 3| 1| 3| 3| 3|
| 9| 0| 8| 0| 7| 3| 8| 9| 3| 4| 5| 5| 5| 0| 1| 2| 6| 2| 9| 1| 1| 1| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic | 2 2 1 |
Pigmentation, Hemosiderin | |
Thrombosis | |
Bronchus, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Respiratory Epithelium, Inflammation | 1 1 1 |
__________________________________________________________________________|
Pleura | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | |
Cornea, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Harderian Gland | + + |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 2 |
Inflammation | 2 |
Nephropathy | 2 2 2 2 2 1 1 2 3 1 2 1 2 2 2 1 1 1 1 1 1 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 6| 7| 6| 6| 6| 2| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 0| 6| 3| 2| 3| 9| 6| 4| 0| 3| 3| 2| 3| 3| 3| 2| 3| 2| 2| 3| 3| 1| 3| 3|
| 1| 9| 1| 0| 7| 0| 0| 8| 0| 5| 0| 0| 9| 0| 9| 0| 9| 7| 0| 9| 0| 0| 1| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + A + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 |
Basophilic Focus | |
Clear Cell Focus | X X |
Depletion Glycogen | 2 2 1 1 2 2 1 1 1 2 2 1 |
Eosinophilic Focus | |
Fibrosis | |
Hematopoietic Cell Proliferation | 2 2 1 2 1 2 3 1 1|
Inflammation | |
Necrosis | 4 3 |
Pigmentation, Hemosiderin | 3 |
Vacuolization Cytoplasmic | 2 2 2 1 1 2 2 2 1 2|
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Mesentery | + + + + + + +|
Inflammation, Chronic | |
Necrosis | 4 4 4 4 4 4|
__________________________________________________________________________|
Pancreas | + A + + + + + + + + + + + + A + + + + + + + + + +|
Atrophy | 2 |
Hyperplasia, Lymphoid | |
Inflammation, Chronic | 3 3 3 2 1 2 3 1 2 4 |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 |
Inflammation, Chronic | 2 2 2 1 2 2 2 1 3 2 2 1 1 2 3 1 |
__________________________________________________________________________|
Stomach, Forestomach | + A + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Stomach, Glandular | + A + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Liver | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 6| 7| 6| 6| 6| 2| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 0| 6| 3| 2| 3| 9| 6| 4| 0| 3| 3| 2| 3| 3| 3| 2| 3| 2| 2| 3| 3| 1| 3| 3|
| 1| 9| 1| 0| 7| 0| 0| 8| 0| 5| 0| 0| 9| 0| 9| 0| 9| 7| 0| 9| 0| 0| 1| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Epithelium, Atrophy | 3 |
Epithelium, Hyperplasia | 3 |
Epithelium, Metaplasia, Squamous | |
Epithelium, Mineralization | |
Serosa, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Degeneration | 2 1 3 2 2 1 2 2 2 2 2 3 3 2 2 2 2 2 2 2 3 1 3|
Inflammation, Chronic | |
Mineralization | |
Thrombosis | |
Epicardium, Hyperplasia, Lymphoid | 1 |
Epicardium, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + A + + + + + + M + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 1 |
Angiectasis | 2 |
Hematopoietic Cell Proliferation | 2 |
Vacuolization Cytoplasmic | |
Capsule, Hyperplasia | 2 |
Zona Glomerulosa, Atrophy | |
Zona Glomerulosa, Hyperplasia | 2 2 |
Zona Reticularis, Hyperplasia | 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + A + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + A + + + + + + + + + + + + A + + + + + + + + + +|
Hyperplasia | 2 4 4 3 3 3 1 2 2 3 2 3 2 4 4 3 3 3|
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Parathyroid Gland | + + I + + + + + + + + I + + + + I + + + + I + + I|
Cyst | |
Infiltration Cellular, Lymphocyte | 2 |
__________________________________________________________________________|
Pituitary Gland | + A M + + M + + M + + + + + + + + + + + + + + + +|
Hemorrhage | |
Pars Distalis, Hyperplasia | 1 1 3 2 1 3 1 |
Pars Intermedia, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 2 2 2 1 3 1 3 1 2 3 1 3 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 6| 7| 6| 6| 6| 2| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 0| 6| 3| 2| 3| 9| 6| 4| 0| 3| 3| 2| 3| 3| 3| 2| 3| 2| 2| 3| 3| 1| 3| 3|
| 1| 9| 1| 0| 7| 0| 0| 8| 0| 5| 0| 0| 9| 0| 9| 0| 9| 7| 0| 9| 0| 0| 1| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Clitoral Gland | + I + + + + + + I + I + + + + + + + + + + + + + +|
Atrophy | 1 2 2 1 1 1 2 |
Hyperplasia | 2 2 |
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Ovary | + A + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Cyst | 3 2 2 |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | |
Inflammation, Chronic | 4 |
Necrosis | |
Thrombosis | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diestrus | |
Hydrometra | |
Inflammation, Chronic Active | 3 |
Endometrium, Angiectasis | |
Endometrium, Hyperplasia, Cystic | 3 1 2 4 3 3 4 2 4 2 3 3 3 3 3 3 3 2 3 3 2 2 4 4|
__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diestrus | |
Inflammation, Acute | |
Inflammation, Chronic | 3 2 |
Epithelium, Hyperplasia | |
Epithelium, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 1 |
Myelofibrosis | 2 1 2 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Lymph Node | + + + + + + +|
Ectasia | |
Hyperplasia | 2 3 |
Infiltration Cellular, Plasma Cell | |
Iliac, Hyperplasia | |
Iliac, Inflammation, Acute | |
Mediastinal, Hyperplasia | 4 |
Renal, Inflammation, Acute | |
__________________________________________________________________________|
Lymph Node, Mandibular | I A + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hemorrhage | 2 |
Hyperplasia | 1 2 1 2 3 1 4 |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + A + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 6| 7| 6| 6| 6| 2| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 0| 6| 3| 2| 3| 9| 6| 4| 0| 3| 3| 2| 3| 3| 3| 2| 3| 2| 2| 3| 3| 1| 3| 3|
| 1| 9| 1| 0| 7| 0| 0| 8| 0| 5| 0| 0| 9| 0| 9| 0| 9| 7| 0| 9| 0| 0| 1| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Atrophy | 1 4 |
Hyperplasia | 2 |
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Spleen | + A + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 3 3 3 2 4 3 3 4 3 3 |
Pigmentation, Hemosiderin | 1 1 2 1 1 2 1 3 1 |
Capsule, Inflammation, Chronic | |
Lymphoid Follicle, Atrophy | |
Lymphoid Follicle, Hyperplasia | 3 3 3 3 2 2 2 3 4 1 1 3 3 1 |
Red Pulp, Atrophy | |
__________________________________________________________________________|
Thymus | + A + + + + I + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 1 2 3 3 1 3 1 3 4 2 2 4 3 2 2 4 4 2|
Hyperplasia, Lymphoid | 2 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + I + + + + + + + + + + + + + + + + I|
Hyperplasia | 2 |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Inflammation, Chronic | |
Hair Follicle, Atrophy | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Degeneration | |
Metaplasia, Osseous | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 1 |
Inflammation, Chronic | |
Meninges, Infiltration Cellular, | |
Lymphocyte | 1 |
Thalamus, Mineralization | 2 2 1 2 2 2 2 2 2 2 2 2 1 2 2 |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + A + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 6| 7| 6| 6| 6| 2| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 0| 6| 3| 2| 3| 9| 6| 4| 0| 3| 3| 2| 3| 3| 3| 2| 3| 2| 2| 3| 3| 1| 3| 3|
| 1| 9| 1| 0| 7| 0| 0| 8| 0| 5| 0| 0| 9| 0| 9| 0| 9| 7| 0| 9| 0| 0| 1| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic | 2 2 1 |
Pigmentation, Hemosiderin | |
Thrombosis | |
Bronchus, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Respiratory Epithelium, Inflammation | 1 1 1 1 1 |
__________________________________________________________________________|
Pleura | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Cataract | 2 |
Cornea, Inflammation, Chronic | 2 1 |
__________________________________________________________________________|
Harderian Gland | + + + + +|
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + A + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 4 3 |
Inflammation | |
Nephropathy | 2 2 1 1 2 2 2 2 2 2 2 3 2 2 3 2 2 2 2 3 1 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 1| 3| 2| 1| 3| 3| 2| 2| 9| 5| 2| 3| 3| 3| 2| 3| 8| 3| 7| 3| 2| 1| 3| 7| 4|
| 1| 1| 9| 1| 0| 1| 1| 9| 0| 4| 9| 0| 0| 1| 9| 4| 8| 0| 9| 1| 9| 1| 1| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + A I + + + + + + + + A + A + + + + A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + A + A + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A + + + + + + + A + A + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + A + A + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + A + A + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + A + A + + + + + +|
Inflammation, Chronic | |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + A + A + + + + + +|
Inflammation, Chronic | |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + A + + + + + + + +|
Atrophy | 3 2 |
Basophilic Focus | |
Clear Cell Focus | X X X |
Depletion Glycogen | 2 2 1 2 2 2 2 1 |
Eosinophilic Focus | X X |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 2 1 2 2 3 2 2 2 1 1 |
Inflammation | 2 |
Necrosis | 1 |
Pigmentation, Hemosiderin | |
Vacuolization Cytoplasmic | 2 2 2 2 2 3 3 2 2 2 3|
Serosa, Inflammation, Chronic | 4 |
__________________________________________________________________________|
Mesentery | + + + + + + + + |
Inflammation, Chronic | 4 |
Necrosis | 4 4 4 4 4 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + A + A + + + + + +|
Atrophy | 2 2 |
Hyperplasia, Lymphoid | 3 |
Inflammation, Chronic | 2 2 2 4 2 2 2 4 2 2 2 |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + A + A + + + + + +|
Atrophy | |
Inflammation, Chronic | 2 2 2 2 2 2 2 3 2 2 2 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + A + A + + + + + +|
Serosa, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + A + A + + + + + +|
Ectopic Liver | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 1| 3| 2| 1| 3| 3| 2| 2| 9| 5| 2| 3| 3| 3| 2| 3| 8| 3| 7| 3| 2| 1| 3| 7| 4|
| 1| 1| 9| 1| 0| 1| 1| 9| 0| 4| 9| 0| 0| 1| 9| 4| 8| 0| 9| 1| 9| 1| 1| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Epithelium, Atrophy | |
Epithelium, Hyperplasia | |
Epithelium, Metaplasia, Squamous | |
Epithelium, Mineralization | 1 |
Serosa, Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + A + + + + + + + +|
Cardiomyopathy | 3 |
Degeneration | 2 2 2 4 3 2 4 2 2 2 2 1 2 2 2 1 2 2 2 2 2 2 2 2|
Inflammation, Chronic | |
Mineralization | |
Thrombosis | 4 |
Epicardium, Hyperplasia, Lymphoid | |
Epicardium, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + A + A + + + + + +|
Accessory Adrenal Cortical Nodule | 2 |
Angiectasis | |
Hematopoietic Cell Proliferation | |
Vacuolization Cytoplasmic | 4 |
Capsule, Hyperplasia | 2 |
Zona Glomerulosa, Atrophy | |
Zona Glomerulosa, Hyperplasia | 2 2 2 1|
Zona Reticularis, Hyperplasia | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + A + A + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + A + A + + + + + +|
Hyperplasia | 4 2 2 3 2 3 2 3 2 4 4 3 3 2 3 3 3 2 2 1|
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Parathyroid Gland | + I + I I + I I I + I + + I + I A + A I + I I I +|
Cyst | |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + I + + + + + + + + + A + A + + + + + +|
Hemorrhage | |
Pars Distalis, Hyperplasia | 2 2 3 2 3 2 2 2 |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + A + A + + + + + +|
Follicular Cell, Hyperplasia | 2 1 1 2 3 2 2 2 2 2 2 3 3 2 1 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 1| 3| 2| 1| 3| 3| 2| 2| 9| 5| 2| 3| 3| 3| 2| 3| 8| 3| 7| 3| 2| 1| 3| 7| 4|
| 1| 1| 9| 1| 0| 1| 1| 9| 0| 4| 9| 0| 0| 1| 9| 4| 8| 0| 9| 1| 9| 1| 1| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Clitoral Gland | I + + I + + + + + + + + I + + + A + I + + + I + +|
Atrophy | 2 1 2 1 |
Hyperplasia | 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + A + A + + + + + +|
Angiectasis | |
Cyst | 2 2 4 4 |
Hemorrhage | |
Hyperplasia, Lymphoid | 3 |
Inflammation, Chronic | |
Necrosis | |
Thrombosis | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diestrus | |
Hydrometra | |
Inflammation, Chronic Active | |
Endometrium, Angiectasis | |
Endometrium, Hyperplasia, Cystic | 4 3 3 4 4 4 3 3 3 4 4 4 4 3 2 3 4 3 3 4 2 3 2 3|
__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + A + + + + + + + +|
Diestrus | |
Inflammation, Acute | 3 |
Inflammation, Chronic | |
Epithelium, Hyperplasia | 3 |
Epithelium, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + I + + + A + + + + + + + +|
Hyperplasia | 2 2 2 3 |
Myelofibrosis | 1 2 2 1 1 1 2 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Lymph Node | + + + + +|
Ectasia | |
Hyperplasia | |
Infiltration Cellular, Plasma Cell | 4 |
Iliac, Hyperplasia | |
Iliac, Inflammation, Acute | |
Mediastinal, Hyperplasia | 3 |
Renal, Inflammation, Acute | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + A + A + + + + + +|
Atrophy | 2 |
Hemorrhage | |
Hyperplasia | 4 2 3 2 |
Pigmentation, Hemosiderin | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + A + A + + + + + +|
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 1| 3| 2| 1| 3| 3| 2| 2| 9| 5| 2| 3| 3| 3| 2| 3| 8| 3| 7| 3| 2| 1| 3| 7| 4|
| 1| 1| 9| 1| 0| 1| 1| 9| 0| 4| 9| 0| 0| 1| 9| 4| 8| 0| 9| 1| 9| 1| 1| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Atrophy | 2 1 2 2 1 2 2 2 |
Hyperplasia | 2 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + A + A + + + + + +|
Hematopoietic Cell Proliferation | 2 4 3 3 3 4 3 3 3 2 3|
Pigmentation, Hemosiderin | 2 2 2 1 1 2 1 2 2 2 3 2 2 2 2 2 2 2 |
Capsule, Inflammation, Chronic | 3 |
Lymphoid Follicle, Atrophy | |
Lymphoid Follicle, Hyperplasia | 2 2 2 3 3 3 2 2 3 3 3 4 2 3 2 2 2 |
Red Pulp, Atrophy | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + A + A + + + + + +|
Atrophy | 4 3 2 4 2 2 3 4 4 4 1 3 3 4 1 2 3 2 3 2 3|
Hyperplasia, Lymphoid | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + I + + + + + + + + + + + + A + A + + + + + +|
Hyperplasia | |
Inflammation, Chronic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + A + A + + + + + +|
Edema | |
Inflammation, Chronic | |
Hair Follicle, Atrophy | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + |
Degeneration | 1 |
Metaplasia, Osseous | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + A + + + + + +|
Hydrocephalus | |
Inflammation, Chronic | |
Meninges, Infiltration Cellular, | |
Lymphocyte | |
Thalamus, Mineralization | 2 2 2 2 2 2 1 2 2 2 1 2 2 2|
__________________________________________________________________________|
Peripheral Nerve | + + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + A + + + + + + + +|
Edema | 2 4 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 1| 3| 2| 1| 3| 3| 2| 2| 9| 5| 2| 3| 3| 3| 2| 3| 8| 3| 7| 3| 2| 1| 3| 7| 4|
| 1| 1| 9| 1| 0| 1| 1| 9| 0| 4| 9| 0| 0| 1| 9| 4| 8| 0| 9| 1| 9| 1| 1| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic | 1 1 1 2 2 |
Pigmentation, Hemosiderin | 1 |
Thrombosis | 3 |
Bronchus, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Respiratory Epithelium, Inflammation | 1 1 1 |
__________________________________________________________________________|
Pleura | + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | |
Cornea, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Harderian Gland | + + + |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + A + + + + + + + +|
Hydronephrosis | |
Inflammation | |
Nephropathy | 1 2 2 3 2 3 2 2 2 2 1 1 2 1 2 2 2 3 2 2 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + A + + + + + + + +|
Degeneration | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
__________________________________________________________________________________________________________________________________
| 7| 3| 7| 7| 7| 7| 5| 3| 7| 5| 5| 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7| 6| |
DAY ON TEST | 3| 1| 2| 3| 3| 2| 3| 1| 2| 4| 4| 2| 2| 4| 2| 2| 2| 4| 2| 9| 2| 7| 2| 3| 7| |
| 0| 4| 9| 0| 0| 9| 2| 4| 9| 8| 2| 9| 8| 8| 9| 9| 9| 8| 9| 4| 9| 5| 2| 1| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
VEHICLE | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Gallbladder | + A + + + + + + + + + + + + + + + + + + + + A + +| 87 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + + + A + + + + + + + + + + + + + + + + + +| 93 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + + A A + + + + + + + + + + + + + + + + +| 91 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + A A + + + + + + + + + + + + + + + + +| 92 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + A A + + + + + + + + + + + + + + + + +| 90 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + A A + + + + + + + + + + + + + + + + +| 90 |
Inflammation, Chronic | | 1 2.0|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + A A + + + + + + + + + + + + + + + + +| 90 |
Inflammation, Chronic | | 1 2.0|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
Atrophy | 1 2 1 2 | 10 1.8|
Basophilic Focus | X | 1 |
Clear Cell Focus | X X | 10 |
Depletion Glycogen | 2 1 2 2 2 2 3 2 3 | 37 1.8|
Eosinophilic Focus | | 3 |
Fibrosis | 1 | 2 1.5|
Hematopoietic Cell Proliferation | 2 1 3 2 2 2 | 35 1.8|
Inflammation | 3 | 2 2.5|
Necrosis | 3 1 | 5 2.4|
Pigmentation, Hemosiderin | 2 | 2 2.5|
Vacuolization Cytoplasmic | 1 3 2 2 3 2 1 2 3 2 | 43 2.1|
Serosa, Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 25 |
Inflammation, Chronic | | 1 4.0|
Necrosis | 4 4 4 4 4 | 23 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + I + + + + + + + + + + + + + + +| 95 |
Atrophy | 4 | 8 2.1|
Hyperplasia, Lymphoid | | 1 3.0|
Inflammation, Chronic | 2 2 4 2 2 2 2| 40 2.1|
Duct, Cyst | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 97 |
Atrophy | 2 1 1 | 6 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
__________________________________________________________________________________________________________________________________
| 7| 3| 7| 7| 7| 7| 5| 3| 7| 5| 5| 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7| 6| |
DAY ON TEST | 3| 1| 2| 3| 3| 2| 3| 1| 2| 4| 4| 2| 2| 4| 2| 2| 2| 4| 2| 9| 2| 7| 2| 3| 7| |
| 0| 4| 9| 0| 0| 9| 2| 4| 9| 8| 2| 9| 8| 8| 9| 9| 9| 8| 9| 4| 9| 5| 2| 1| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
VEHICLE | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 2 2 1 1 1 2| 61 1.9|
__________________________________________________________________________|____________|
Stomach, Forestomach | + A + + + + + A + + + + + + + + + + + + + + + + +| 93 |
Serosa, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + A + + + + + A + + + + + + + + + + + + + + + + +| 93 |
Ectopic Liver | 3 | 1 3.0|
Epithelium, Atrophy | | 1 3.0|
Epithelium, Hyperplasia | | 1 3.0|
Epithelium, Metaplasia, Squamous | 2 | 1 2.0|
Epithelium, Mineralization | | 1 1.0|
Serosa, Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
Cardiomyopathy | 2 4 4 | 4 3.3|
Degeneration | 2 2 2 3 1 2 3 1 2 2 2 2 2 2 2 2 2 2 2 1 1 1 2| 92 2.0|
Inflammation, Chronic | 2 | 1 2.0|
Mineralization | 1 | 1 1.0|
Thrombosis | | 1 4.0|
Epicardium, Hyperplasia, Lymphoid | | 1 1.0|
Epicardium, Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + I + + + + + + + + M + + + + + +| 94 |
Accessory Adrenal Cortical Nodule | 1 | 4 1.3|
Angiectasis | | 2 2.5|
Hematopoietic Cell Proliferation | | 1 2.0|
Vacuolization Cytoplasmic | | 1 4.0|
Capsule, Hyperplasia | 2 | 5 2.2|
Zona Glomerulosa, Atrophy | 1 | 1 1.0|
Zona Glomerulosa, Hyperplasia | 2 | 9 1.9|
Zona Reticularis, Hyperplasia | | 4 1.3|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + I + + + + + + + + M + + + + + +| 94 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + A + + + + + + + I + + + + + + + + + + + + + + +| 94 |
Hyperplasia | 3 3 4 3 2 2 1 3 2 3 2 2 3 1 3 2 3 2 3 2| 80 2.6|
Infiltration Cellular, Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | I A + I + I I I + I + I I + I + + + + I + + + I +| 59 |
Cyst | 2 | 1 2.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + M + + + + + I + + + M + + + + + + + + + M +| 86 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
__________________________________________________________________________________________________________________________________
| 7| 3| 7| 7| 7| 7| 5| 3| 7| 5| 5| 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7| 6| |
DAY ON TEST | 3| 1| 2| 3| 3| 2| 3| 1| 2| 4| 4| 2| 2| 4| 2| 2| 2| 4| 2| 9| 2| 7| 2| 3| 7| |
| 0| 4| 9| 0| 0| 9| 2| 4| 9| 8| 2| 9| 8| 8| 9| 9| 9| 8| 9| 4| 9| 5| 2| 1| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
VEHICLE | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hemorrhage | 2 | 1 2.0|
Pars Distalis, Hyperplasia | 3 2 4 1 2 3 | 28 2.1|
Pars Intermedia, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + A + + + + + I + + + + + + + + + + + + + + + + +| 96 |
Follicular Cell, Hyperplasia | 2 3 3 1 2 2 3 2 2 2 3 1 2| 57 2.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + I + + + + + I I + + I + + + + + + I + I I + + +| 81 |
Atrophy | 1 2 2 2 1 2 1 | 26 1.6|
Hyperplasia | 3 2 | 8 2.0|
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 97 |
Angiectasis | | 1 4.0|
Cyst | 3 2 2 | 13 2.7|
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
Inflammation, Chronic | | 2 4.0|
Necrosis | | 2 4.0|
Thrombosis | 4 | 2 3.5|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Diestrus | X | 1 |
Hydrometra | 4 | 2 4.0|
Inflammation, Chronic Active | | 1 3.0|
Endometrium, Angiectasis | | 1 3.0|
Endometrium, Hyperplasia, Cystic | 4 2 4 3 3 3 2 2 2 2 2 3 3 1 2 3 3 2 4 3 4 4 2 3 4| 97 3.1|
__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
Diestrus | X | 1 |
Inflammation, Acute | | 2 3.0|
Inflammation, Chronic | | 2 2.5|
Epithelium, Hyperplasia | | 1 3.0|
Epithelium, Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 98 |
Hyperplasia | 3 2 | 16 2.1|
Myelofibrosis | 3 2 1 1 1 1| 19 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
__________________________________________________________________________________________________________________________________
| 7| 3| 7| 7| 7| 7| 5| 3| 7| 5| 5| 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7| 6| |
DAY ON TEST | 3| 1| 2| 3| 3| 2| 3| 1| 2| 4| 4| 2| 2| 4| 2| 2| 2| 4| 2| 9| 2| 7| 2| 3| 7| |
| 0| 4| 9| 0| 0| 9| 2| 4| 9| 8| 2| 9| 8| 8| 9| 9| 9| 8| 9| 4| 9| 5| 2| 1| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
VEHICLE | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pigmentation, Hemosiderin | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + | 21 |
Ectasia | | 1 4.0|
Hyperplasia | | 3 2.7|
Infiltration Cellular, Plasma Cell | | 1 4.0|
Iliac, Hyperplasia | | 1 3.0|
Iliac, Inflammation, Acute | 2 | 1 2.0|
Mediastinal, Hyperplasia | | 3 3.7|
Renal, Inflammation, Acute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + I + + + + + +| 94 |
Atrophy | 2 2 1 2| 6 2.0|
Hemorrhage | | 1 2.0|
Hyperplasia | 2 3 4 | 18 2.3|
Pigmentation, Hemosiderin | | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + A + + + + + + + I + + + + + + + + + + + + + + +| 93 |
Atrophy | 1 3 | 14 1.9|
Hyperplasia | 2 | 6 2.0|
Inflammation, Chronic | | 2 4.0|
__________________________________________________________________________|____________|
Spleen | + A + + + + + + + + + + + + + + + + + + + + + + +| 96 |
Hematopoietic Cell Proliferation | 3 2 3 3 3 3 2 4 3 4 1 4 3 3 3 4 3| 56 3.0|
Pigmentation, Hemosiderin | 2 2 2 2 2 2 2 1 2| 49 1.8|
Capsule, Inflammation, Chronic | | 1 3.0|
Lymphoid Follicle, Atrophy | | 1 2.0|
Lymphoid Follicle, Hyperplasia | 3 3 3 3 3 3 2 2 3 3 3 3 3 3 3 2| 65 2.7|
Red Pulp, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + I + + + M + + + + + + + + + + +| 93 |
Atrophy | 2 2 3 3 4 4 4 2 2 1 2 1 3 2 1 3 2 2 4 1| 82 2.6|
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + I + + + + + + I + + + + + + + + + + +| 92 |
Hyperplasia | | 5 1.8|
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 98 |
Edema | | 2 2.5|
Inflammation, Chronic | 4 4 | 4 3.3|
Hair Follicle, Atrophy | 2| 2 1.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
__________________________________________________________________________________________________________________________________
| 7| 3| 7| 7| 7| 7| 5| 3| 7| 5| 5| 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7| 6| |
DAY ON TEST | 3| 1| 2| 3| 3| 2| 3| 1| 2| 4| 4| 2| 2| 4| 2| 2| 2| 4| 2| 9| 2| 7| 2| 3| 7| |
| 0| 4| 9| 0| 0| 9| 2| 4| 9| 8| 2| 9| 8| 8| 9| 9| 9| 8| 9| 4| 9| 5| 2| 1| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
VEHICLE | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + +| 10 |
Degeneration | | 1 1.0|
Metaplasia, Osseous | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
Hydrocephalus | | 3 1.3|
Inflammation, Chronic | 1 | 1 1.0|
Meninges, Infiltration Cellular, | | |
Lymphocyte | | 1 1.0|
Thalamus, Mineralization | 2 2 2 2 2 1 2 2 2 2 2 1 1 2 | 53 1.9|
__________________________________________________________________________|____________|
Peripheral Nerve | | 4 |
__________________________________________________________________________|____________|
Spinal Cord | | 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 98 |
Edema | 2 2 | 9 2.1|
Hemorrhage | | 3 1.7|
Inflammation, Chronic | 2 2 3 2 1 2| 17 1.7|
Pigmentation, Hemosiderin | | 1 1.0|
Thrombosis | | 1 3.0|
Bronchus, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Respiratory Epithelium, Inflammation | 1 1 1 1 | 15 1.0|
__________________________________________________________________________|____________|
Pleura | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 6 |
Cataract | 2 | 2 2.0|
Cornea, Inflammation, Chronic | | 4 1.3|
__________________________________________________________________________|____________|
Harderian Gland | + | 11 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 98 |
Hydronephrosis | | 3 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
__________________________________________________________________________________________________________________________________
| 7| 3| 7| 7| 7| 7| 5| 3| 7| 5| 5| 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7| 6| |
DAY ON TEST | 3| 1| 2| 3| 3| 2| 3| 1| 2| 4| 4| 2| 2| 4| 2| 2| 2| 4| 2| 9| 2| 7| 2| 3| 7| |
| 0| 4| 9| 0| 0| 9| 2| 4| 9| 8| 2| 9| 8| 8| 9| 9| 9| 8| 9| 4| 9| 5| 2| 1| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
VEHICLE | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Inflammation | | 1 2.0|
Nephropathy | 2 1 2 2 2 2 2 3 2 2 3 2 3 2 2 2 1 3 2 2 1 3 2| 90 1.9|
__________________________________________________________________________|____________|
Urinary Bladder | + A + + + + M + + I + + + + + + + + + + + + + + +| 96 |
Degeneration | 1 | 1 1.0|
Inflammation, Chronic | 2 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 3| 6| 6| 7| 7| 6| 6| 7| 6| 7| 3| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 2| 3| 3| 2| 7| 8| 6| 3| 3| 2| 5| 2| 4| 3| 1| 2| 3| 3| 3| 3| 3| 3|
| 0| 1| 0| 9| 0| 1| 9| 2| 2| 8| 1| 0| 4| 1| 9| 6| 0| 3| 9| 0| 0| 4| 1| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Periesophageal Tissue, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Gallbladder | + + I + + + + + + + + + I A + + + A + + + A + + I|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + A + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + A + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + A + + + A + + +|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + A + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + A + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Clear Cell Focus | |
Depletion Glycogen | 2 2 2 2 3 1 1 1 2 1 2|
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | 2 1 1 3 2|
Infarct | 3 |
Inflammation | |
Necrosis | 4 |
Vacuolization Cytoplasmic | 4 2 2 2 3 2 1 2 3 2 2 2 2 1|
__________________________________________________________________________|
Mesentery | + + + + + + + + |
Necrosis | 4 4 4 4 4 4 4 |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + I + + +|
Atrophy | 3 |
Inflammation, Chronic | 2 1 2 1 3 2 2 3 2 3 |
Acinus, Atrophy | |
Duct, Dilatation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Inflammation, Chronic | 2 2 2 2 3 1 2 2 1 2 2 2 2 2 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + A + + + + + + + A + + +|
Inflammation | |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + A + + + + + + + A + + +|
Inflammation, Chronic | |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Metaplasia, Osseous | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 3| 6| 6| 7| 7| 6| 6| 7| 6| 7| 3| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 2| 3| 3| 2| 7| 8| 6| 3| 3| 2| 5| 2| 4| 3| 1| 2| 3| 3| 3| 3| 3| 3|
| 0| 1| 0| 9| 0| 1| 9| 2| 2| 8| 1| 0| 4| 1| 9| 6| 0| 3| 9| 0| 0| 4| 1| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 2 |
Degeneration | 2 2 2 2 2 2 2 2 3 2 2 2 3 2 3 2 3 1 2 2 1 2 2|
Inflammation, Chronic | |
Valve, Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 |
Capsule, Hyperplasia | 2 2 4 |
Zona Glomerulosa, Hyperplasia | 2 1 2 2 |
Zona Reticularis, Hematopoietic Cell | |
Proliferation | |
Zona Reticularis, Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + I + + + + + + + I + + + + +|
Hemorrhage | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + I + + + + + + + + + + + + I + + +|
Atrophy | 4 |
Hyperplasia | 4 2 2 3 4 1 2 2 3 2 3 3 3 3 2 2 2|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + I + I + I I I + + + + I + I I I + + +|
Hyperplasia | |
Inflammation, Chronic | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + M + + + + + + M + + I + + + + +|
Pars Distalis, Hyperplasia | 1 2 2 2 1 |
Pars Intermedia, Angiectasis | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Follicular Cell, Cyst | |
Follicular Cell, Hyperplasia | 2 2 2 3 2 3 3 1 1 1 2 2 2 2 2 1 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + I + + I + + A + + +|
Atrophy | 2 1 3 2 2 1|
Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + A + + +|
Cyst | 2 3 2 |
Hemorrhage | 2 |
Hyperplasia, Tubulostromal | 3 |
Inflammation, Chronic | 4 4 |
Necrosis | 2 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 3| 6| 6| 7| 7| 6| 6| 7| 6| 7| 3| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 2| 3| 3| 2| 7| 8| 6| 3| 3| 2| 5| 2| 4| 3| 1| 2| 3| 3| 3| 3| 3| 3|
| 0| 1| 0| 9| 0| 1| 9| 2| 2| 8| 1| 0| 4| 1| 9| 6| 0| 3| 9| 0| 0| 4| 1| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hydrometra | |
Endometrium, Hyperplasia, Cystic | 3 3 4 4 4 2 2 2 2 2 4 4 4 4 4 4 3 2 4 3 3 3 3 4 4|
__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 2 |
Infiltration Cellular, Histiocyte | 2 |
Myelofibrosis | 1 3 2 1 1 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + |
Iliac, Hemorrhage, Chronic | 4 |
Iliac, Hyperplasia | |
Mediastinal, Hyperplasia | 3 |
Renal, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | I + + + + + + + + + + + + + + + + + + + + I + + +|
Atrophy | 2 1 2 |
Hyperplasia | 2 4 3 |
Infiltration Cellular, Histiocyte | 2 |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + A + + +|
Atrophy | 2 2 2 |
Hyperplasia | 4 3 1 1 |
Inflammation, Chronic | |
Necrosis | 2 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + A + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 3 3 2 3 3 3 3 3 4 1 4 2 2 3 2|
Inflammation, Chronic | |
Pigmentation, Hemosiderin | 2 2 2 2 2 1 2 1 2 1 1|
Lymphoid Follicle, Atrophy | 2 2 |
Lymphoid Follicle, Hyperplasia | 3 3 3 3 3 3 3 3 3 4 3 2 3 4 2 3 3|
Red Pulp, Atrophy | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 1 1 1 2 2 4 2 1 3 1 1 2 1 2 1 1 1 2|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + I + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 3| 6| 6| 7| 7| 6| 6| 7| 6| 7| 3| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 2| 3| 3| 2| 7| 8| 6| 3| 3| 2| 5| 2| 4| 3| 1| 2| 3| 3| 3| 3| 3| 3|
| 0| 1| 0| 9| 0| 1| 9| 2| 2| 8| 1| 0| 4| 1| 9| 6| 0| 3| 9| 0| 0| 4| 1| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Hyperplasia | |
Hair Follicle, Atrophy | |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
Vulva, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 |
Osteoporosis | |
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | |
Infiltration Cellular, Lymphocyte | |
Choroid Plexus, Hyperplasia | |
Thalamus, Mineralization | 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Peripheral Nerve | + + |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 1 |
Hemorrhage | 2 |
Inflammation, Acute | |
Inflammation, Chronic | 2 2 2 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Respiratory Epithelium, Inflammation | 1 1 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peritracheal Tissue, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 3| 6| 6| 7| 7| 6| 6| 7| 6| 7| 3| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 2| 3| 3| 2| 7| 8| 6| 3| 3| 2| 5| 2| 4| 3| 1| 2| 3| 3| 3| 3| 3| 3|
| 0| 1| 0| 9| 0| 1| 9| 2| 2| 8| 1| 0| 4| 1| 9| 6| 0| 3| 9| 0| 0| 4| 1| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Congestion | 3 |
Hydronephrosis | 2 |
Inflammation | |
Nephropathy | 1 1 2 2 2 1 2 1 1 2 1 2 2 2 2 3 1 2 2 2 1 2 2 2|
Glomerulus, Amyloid Deposition | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 5| 7| 5| 3| 1| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 1| 4| 6| 3| 2| 9| 3| 3| 5| 3| 0| 2| 1| 2| 9| 4| 9| 2| 2| 3| 2| 2| 3|
| 9| 9| 4| 2| 1| 1| 9| 7| 0| 1| 3| 0| 7| 4| 2| 7| 0| 0| 6| 1| 9| 0| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + I + + + + + + + + + + + + + + + + + + + + + + +|
Periesophageal Tissue, Inflammation, | |
Chronic | 3 |
__________________________________________________________________________|
Gallbladder | + + A + + + + A + + + + + + + A + + + A + + + I +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + + +|
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + + + + + + +|
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + A + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Clear Cell Focus | |
Depletion Glycogen | 1 2 2 1 |
Eosinophilic Focus | |
Hematopoietic Cell Proliferation | 2 2 2 1 1 1 1|
Infarct | |
Inflammation | |
Necrosis | 3 |
Vacuolization Cytoplasmic | 2 3 2 1 2 2 1 2|
__________________________________________________________________________|
Mesentery | + + + + + + + + + |
Necrosis | 4 4 4 4 4 4 |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Inflammation, Chronic | 2 2 2 3 1 3 2 |
Acinus, Atrophy | 3 |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Inflammation, Chronic | 2 2 3 2 2 1 2 4 1 1 1 1 2 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Epithelium, Hyperplasia | 2 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Metaplasia, Osseous | |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 5| 7| 5| 3| 1| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 1| 4| 6| 3| 2| 9| 3| 3| 5| 3| 0| 2| 1| 2| 9| 4| 9| 2| 2| 3| 2| 2| 3|
| 9| 9| 4| 2| 1| 1| 9| 7| 0| 1| 3| 0| 7| 4| 2| 7| 0| 0| 6| 1| 9| 0| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Degeneration | 2 2 2 2 2 3 2 2 2 1 2 2 1 2 2 2 2 2 2 2|
Inflammation, Chronic | |
Valve, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + I + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Capsule, Hyperplasia | |
Zona Glomerulosa, Hyperplasia | 2 2 2 2 |
Zona Reticularis, Hematopoietic Cell | |
Proliferation | |
Zona Reticularis, Hyperplasia | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + I + + + I + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Hyperplasia | 2 3 2 3 3 2 3 2 3 4 2 3 3 1 3 2 2|
__________________________________________________________________________|
Parathyroid Gland | + + I I + + + + + + + + I + + + I + + I + I + + +|
Hyperplasia | |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + M + + M + + + + + + + + +|
Pars Distalis, Hyperplasia | 1 4 2 4 3 2|
Pars Intermedia, Angiectasis | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
Follicular Cell, Cyst | 3 |
Follicular Cell, Hyperplasia | 1 3 3 3 2 2 3 3 2 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + I + + + + + + + + I I I + + + + + I + +|
Atrophy | 1 2|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + M + + + + + + + + + + + + + + + +|
Cyst | 3 2 3 2|
Hemorrhage | 2 |
Hyperplasia, Tubulostromal | |
Inflammation, Chronic | |
Necrosis | 2 |
Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 5| 7| 5| 3| 1| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 1| 4| 6| 3| 2| 9| 3| 3| 5| 3| 0| 2| 1| 2| 9| 4| 9| 2| 2| 3| 2| 2| 3|
| 9| 9| 4| 2| 1| 1| 9| 7| 0| 1| 3| 0| 7| 4| 2| 7| 0| 0| 6| 1| 9| 0| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hydrometra | 3 |
Endometrium, Hyperplasia, Cystic | 2 4 2 1 2 4 3 2 4 4 4 4 2 2 2 4 4 2 3 2 4 4 3 3 3|
__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Infiltration Cellular, Histiocyte | |
Myelofibrosis | 1 1 2 1 2 1 2 1 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Iliac, Hemorrhage, Chronic | |
Iliac, Hyperplasia | 3 |
Mediastinal, Hyperplasia | 3 |
Renal, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + I + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | 2 1 |
Infiltration Cellular, Histiocyte | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + I + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hyperplasia | 2 |
Inflammation, Chronic | 3 |
Necrosis | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 3 3 2 3 3 3 4 4 3 2 3 3 2 3 3 2 2 3 |
Inflammation, Chronic | |
Pigmentation, Hemosiderin | 1 2 1 2 1 2 1 2 1|
Lymphoid Follicle, Atrophy | |
Lymphoid Follicle, Hyperplasia | 3 3 3 2 3 3 3 1 2 3 2 2 3 3 3 2 3 3 |
Red Pulp, Atrophy | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 2 4 3 4 3 1 1 1 3 1 4 4 4 4 3 1 4 4 |
Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + I + I + I + + + + +|
Atrophy | |
Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 5| 7| 5| 3| 1| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 1| 4| 6| 3| 2| 9| 3| 3| 5| 3| 0| 2| 1| 2| 9| 4| 9| 2| 2| 3| 2| 2| 3|
| 9| 9| 4| 2| 1| 1| 9| 7| 0| 1| 3| 0| 7| 4| 2| 7| 0| 0| 6| 1| 9| 0| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Hyperplasia | 2 |
Hair Follicle, Atrophy | 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
Vulva, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 1 |
Osteoporosis | |
__________________________________________________________________________|
Skeletal Muscle | + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 3 |
Infiltration Cellular, Lymphocyte | |
Choroid Plexus, Hyperplasia | |
Thalamus, Mineralization | 2 2 2 2 2 2 2|
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hemorrhage | |
Inflammation, Acute | |
Inflammation, Chronic | 2 3 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Respiratory Epithelium, Inflammation | 1 1 1 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peritracheal Tissue, Inflammation, | |
Chronic | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 5| 7| 5| 3| 1| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 1| 4| 6| 3| 2| 9| 3| 3| 5| 3| 0| 2| 1| 2| 9| 4| 9| 2| 2| 3| 2| 2| 3|
| 9| 9| 4| 2| 1| 1| 9| 7| 0| 1| 3| 0| 7| 4| 2| 7| 0| 0| 6| 1| 9| 0| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Congestion | |
Hydronephrosis | |
Inflammation | |
Nephropathy | 2 3 2 2 2 2 1 2 3 2 2 2 2 2 1 2 2 2 2 2 1 2 2 1|
Glomerulus, Amyloid Deposition | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 0| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 2| 2| 8| 7| 3| 3| 0| 3| 4| 2| 2| 3| 7| 3| 5| 3| 0| 3| 3| 3| 2|
| 0| 1| 1| 0| 9| 9| 6| 2| 0| 0| 1| 0| 6| 0| 9| 0| 5| 0| 8| 8| 8| 0| 1| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Periesophageal Tissue, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + A + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + A + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Clear Cell Focus | X X X X |
Depletion Glycogen | 2 2 2 1 2 2 |
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | 1 2 2 2 2 1 |
Infarct | |
Inflammation | |
Necrosis | 3 2 |
Vacuolization Cytoplasmic | 2 2 1 1 2 2 3 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + + |
Necrosis | 4 4 4 4 4 4 4 |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 |
Inflammation, Chronic | 2 1 2 1 2 2 2 2 1 2 2 2|
Acinus, Atrophy | |
Duct, Dilatation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 2 |
Inflammation, Chronic | 2 2 1 1 1 2 2 1 1 2 2 2 1 2 1 2 2|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2|
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Metaplasia, Osseous | 3 |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 0| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 2| 2| 8| 7| 3| 3| 0| 3| 4| 2| 2| 3| 7| 3| 5| 3| 0| 3| 3| 3| 2|
| 0| 1| 1| 0| 9| 9| 6| 2| 0| 0| 1| 0| 6| 0| 9| 0| 5| 0| 8| 8| 8| 0| 1| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 3 3 |
Degeneration | 2 2 2 1 1 2 2 2 1 2 2 1 3 2 2 1 2 2 2 3 2 2 2 2|
Inflammation, Chronic | 4 |
Valve, Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + M + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Capsule, Hyperplasia | 2 2 |
Zona Glomerulosa, Hyperplasia | 2 2 1 2 2 2 |
Zona Reticularis, Hematopoietic Cell | |
Proliferation | 3 |
Zona Reticularis, Hyperplasia | 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + M + + + + + + + + + + I + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | 2 3 2 1 3 4 3 1 2 1 3 2 2 2 1 3 4 2 4 3 3 3|
__________________________________________________________________________|
Parathyroid Gland | + I + I + + I + + I I + + + I I + + + I + I I + +|
Hyperplasia | 3|
Inflammation, Chronic | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M M + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 1 4 3 1 3 2 1 3 1 3 |
Pars Intermedia, Angiectasis | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Follicular Cell, Cyst | |
Follicular Cell, Hyperplasia | 1 3 3 2 4 3 2 1 2 2 3 2 1 1 2 1 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + I + + + + + + + + I + + + + + I I + + + + +|
Atrophy | 1 1 1 2 2 2 |
Hyperplasia | 1 2 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + I|
Cyst | 2 2 2 |
Hemorrhage | |
Hyperplasia, Tubulostromal | |
Inflammation, Chronic | |
Necrosis | 2 2 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 0| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 2| 2| 8| 7| 3| 3| 0| 3| 4| 2| 2| 3| 7| 3| 5| 3| 0| 3| 3| 3| 2|
| 0| 1| 1| 0| 9| 9| 6| 2| 0| 0| 1| 0| 6| 0| 9| 0| 5| 0| 8| 8| 8| 0| 1| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hydrometra | 3|
Endometrium, Hyperplasia, Cystic | 3 4 4 3 2 4 2 2 4 2 4 2 3 3 4 3 3 3 1 3 3 3 3 4|
__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 2 |
Infiltration Cellular, Histiocyte | |
Myelofibrosis | 1 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + |
Iliac, Hemorrhage, Chronic | |
Iliac, Hyperplasia | 2 |
Mediastinal, Hyperplasia | 2 |
Renal, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 2 2 3 |
Hyperplasia | 2 2 |
Infiltration Cellular, Histiocyte | |
Pigmentation, Hemosiderin | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + A + + + + + + + + + + + + + I + + + +|
Atrophy | 1 2 2 |
Hyperplasia | 1 |
Inflammation, Chronic | |
Necrosis | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Spleen | + + + + + + A + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 3 2 3 3 2 2 4 1 2 1 3 3 4 3 2 3 2|
Inflammation, Chronic | |
Pigmentation, Hemosiderin | 1 2 1 1 2 2 2 2 2 2 2 1 2 2 2|
Lymphoid Follicle, Atrophy | 4 |
Lymphoid Follicle, Hyperplasia | 2 3 2 2 2 3 2 2 1 3 1 3 3 3 3 |
Red Pulp, Atrophy | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 4 1 2 4 2 1 4 3 2 4 4 2 4 4 4 2 2 4|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + I I I + I + I + + + + + + + + + + +|
Atrophy | 2 |
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 0| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 2| 2| 8| 7| 3| 3| 0| 3| 4| 2| 2| 3| 7| 3| 5| 3| 0| 3| 3| 3| 2|
| 0| 1| 1| 0| 9| 9| 6| 2| 0| 0| 1| 0| 6| 0| 9| 0| 5| 0| 8| 8| 8| 0| 1| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Hyperplasia | |
Hair Follicle, Atrophy | |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
Vulva, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
Osteoporosis | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 1 |
Infiltration Cellular, Lymphocyte | |
Choroid Plexus, Hyperplasia | |
Thalamus, Mineralization | 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hemorrhage | |
Inflammation, Acute | |
Inflammation, Chronic | 2 2 2 2 2 3 2 2|
Thrombosis | 3 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Respiratory Epithelium, Inflammation | 1 1 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peritracheal Tissue, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 0| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 2| 2| 8| 7| 3| 3| 0| 3| 4| 2| 2| 3| 7| 3| 5| 3| 0| 3| 3| 3| 2|
| 0| 1| 1| 0| 9| 9| 6| 2| 0| 0| 1| 0| 6| 0| 9| 0| 5| 0| 8| 8| 8| 0| 1| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Congestion | |
Hydronephrosis | 3 |
Inflammation | 3 3 |
Nephropathy | 3 1 1 3 2 1 3 2 3 2 1 2 1 1 2 2 1 3 2 2 2 2|
Glomerulus, Amyloid Deposition | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + A + + + + + + + + + + + + I + + + + +|
Atrophy | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 3| 3| 3| 1| 0| 3| 3| 1| 3| 3| 0| 8| 3| 2| 2| 2| 3| 2| 3| 2| 3| 2| 2| |
| 9| 9| 0| 1| 1| 9| 4| 0| 0| 4| 1| 1| 4| 8| 0| 4| 9| 9| 7| 1| 1| 9| 1| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
25% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
Periesophageal Tissue, Inflammation, | | |
Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Gallbladder | + + + + + + A + + I + + A A I A + + A + + + I + +| 79 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + + + + +| 97 |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + A + + + + + +| 96 |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + + + +| 96 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + + + + + +| 92 |
Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + A + + + + + +| 91 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + + + + + +| 92 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Atrophy | | 2 2.0|
Clear Cell Focus | X X | 6 |
Depletion Glycogen | 1 2 1 3 2 3 2 2 2 | 30 1.8|
Eosinophilic Focus | | 2 |
Hematopoietic Cell Proliferation | 2 1 1 2 2 2 2 | 25 1.6|
Infarct | | 1 3.0|
Inflammation | 2 | 1 2.0|
Necrosis | | 4 3.0|
Vacuolization Cytoplasmic | 2 1 2 2 2 3 2 2 2 | 39 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + +| 36 |
Necrosis | 4 4 4 2 4 4 4 4 4 4 4| 31 3.9|
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + A + + + + + +| 98 |
Atrophy | 2 2 | 6 2.3|
Inflammation, Chronic | 2 2 2 2 2 2 2 | 36 2.0|
Acinus, Atrophy | | 1 3.0|
Duct, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Atrophy | | 5 2.4|
Inflammation, Chronic | 2 2 2 2 2 2 2 1 1 2 2 2 | 58 1.8|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + A + + + + + +| 97 |
Inflammation | | 1 2.0|
Epithelium, Hyperplasia | | 3 1.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + A + + + + + + + + + + + A + + + + + +| 96 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 3| 3| 3| 1| 0| 3| 3| 1| 3| 3| 0| 8| 3| 2| 2| 2| 3| 2| 3| 2| 3| 2| 2| |
| 9| 9| 0| 1| 1| 9| 4| 0| 0| 4| 1| 1| 4| 8| 0| 4| 9| 9| 7| 1| 1| 9| 1| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
25% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Epithelium, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 2 |
Aorta, Metaplasia, Osseous | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Cardiomyopathy | 2 | 6 2.7|
Degeneration | 2 2 3 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2| 90 2.0|
Inflammation, Chronic | | 1 4.0|
Valve, Thrombosis | | 3 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + M + + + + + + + + + +| 97 |
Accessory Adrenal Cortical Nodule | | 1 2.0|
Capsule, Hyperplasia | 2 2 | 7 2.3|
Zona Glomerulosa, Hyperplasia | 2 2 1 | 17 1.8|
Zona Reticularis, Hematopoietic Cell | | |
Proliferation | | 1 3.0|
Zona Reticularis, Hyperplasia | | 3 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + M + + + + + + + I + +| 92 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + A + + + + + +| 97 |
Atrophy | | 2 4.0|
Hyperplasia | 3 3 1 1 3 3 2 3 2 2 3 3 2 2 1 3 2 2 2 3 2 3| 78 2.4|
__________________________________________________________________________|____________|
Parathyroid Gland | I + + + + + + I + + + + + + + + + + + I + I I I +| 69 |
Hyperplasia | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + M + I + + + + + + I I + + M + + + + + + + M + I| 84 |
Pars Distalis, Hyperplasia | 2 3 2 2 3 4 2 | 29 2.3|
Pars Intermedia, Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Inflammation, Chronic | | 1 3.0|
Follicular Cell, Cyst | | 1 3.0|
Follicular Cell, Hyperplasia | 2 2 2 2 2 1 3 2 3 2 4| 58 2.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 3| 3| 3| 1| 0| 3| 3| 1| 3| 3| 0| 8| 3| 2| 2| 2| 3| 2| 3| 2| 3| 2| 2| |
| 9| 9| 0| 1| 1| 9| 4| 0| 0| 4| 1| 1| 4| 8| 0| 4| 9| 9| 7| 1| 1| 9| 1| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
25% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + I I + + + I + + + + + + + I + + I| 83 |
Atrophy | 3 2 1 3 | 18 1.8|
Hyperplasia | 1 2 | 10 1.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 97 |
Cyst | 2 2 3 3 3| 15 2.4|
Hemorrhage | | 2 2.0|
Hyperplasia, Tubulostromal | | 1 3.0|
Inflammation, Chronic | | 2 4.0|
Necrosis | | 4 2.0|
Thrombosis | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Hemorrhage | | 1 2.0|
Hydrometra | | 2 3.0|
Endometrium, Hyperplasia, Cystic | 4 3 3 3 3 3 2 3 4 2 3 3 3 3 2 3 3 3 1 4 4 3 3 3| 98 3.0|
__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Hyperplasia | 2 2 | 11 1.6|
Infiltration Cellular, Histiocyte | | 1 2.0|
Myelofibrosis | 1 1 1 1 3| 26 1.6|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + +| 21 |
Iliac, Hemorrhage, Chronic | | 1 4.0|
Iliac, Hyperplasia | 4 | 3 3.0|
Mediastinal, Hyperplasia | 3 | 4 2.8|
Renal, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + I + I + + + + + + + + + + I I + + + +| 93 |
Atrophy | 1 2 1 2 | 12 1.8|
Hyperplasia | 2 2 3 | 10 2.3|
Infiltration Cellular, Histiocyte | | 1 2.0|
Pigmentation, Hemosiderin | 1 | 3 1.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + I + + + + + + + + + + + + + + + I M + + + + + +| 93 |
Atrophy | 2 1 2 | 10 1.9|
Hyperplasia | | 6 2.0|
Inflammation, Chronic | 2 | 2 2.5|
Necrosis | | 1 2.0|
Pigmentation, Hemosiderin | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 98 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 3| 3| 3| 1| 0| 3| 3| 1| 3| 3| 0| 8| 3| 2| 2| 2| 3| 2| 3| 2| 3| 2| 2| |
| 9| 9| 0| 1| 1| 9| 4| 0| 0| 4| 1| 1| 4| 8| 0| 4| 9| 9| 7| 1| 1| 9| 1| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
25% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 3 2 4 2 3 3 3 3 2 | 59 2.7|
Inflammation, Chronic | 4 | 1 4.0|
Pigmentation, Hemosiderin | 2 2 2 2 1 1 2 2 2 2 2 | 46 1.7|
Lymphoid Follicle, Atrophy | 2 | 4 2.5|
Lymphoid Follicle, Hyperplasia | 3 3 2 3 3 3 3 1 3 3 3 3 3 2 | 64 2.7|
Red Pulp, Atrophy | 2 | 3 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + I + + + + + + + + + + + + + + + + + +| 99 |
Atrophy | 4 3 4 1 4 3 1 2 2 4 3 1 2 4 4 4 4 1 2 2| 79 2.5|
Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 91 |
Atrophy | | 1 2.0|
Hyperplasia | 1 3 1 3 | 7 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Epidermis, Hyperplasia | | 1 2.0|
Hair Follicle, Atrophy | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | 4| 1 4.0|
Vulva, Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Hyperostosis | | 2 1.5|
Osteoporosis | 4| 1 4.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 8 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Hydrocephalus | | 2 2.0|
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
Choroid Plexus, Hyperplasia | 2 | 1 2.0|
Thalamus, Mineralization | 2 2 2 2 2 2 2 2 2 2 1 | 33 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 4 |
__________________________________________________________________________|____________|
Spinal Cord | + | 4 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 88066-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYVINYL ALCOHOL Date: 08/14/96
Route: VAGINAL Time: 18:59:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 3| 3| 3| 1| 0| 3| 3| 1| 3| 3| 0| 8| 3| 2| 2| 2| 3| 2| 3| 2| 3| 2| 2| |
| 9| 9| 0| 1| 1| 9| 4| 0| 0| 4| 1| 1| 4| 8| 0| 4| 9| 9| 7| 1| 1| 9| 1| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
25% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Edema | 2 2 | 3 1.7|
Hemorrhage | 2 | 2 2.0|
Inflammation, Acute | 1 | 1 1.0|
Inflammation, Chronic | 2 2 3 | 16 2.2|
Thrombosis | | 1 3.0|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Hemorrhage | | 1 3.0|
Respiratory Epithelium, Inflammation | 1 1 1 1 1 1 1 | 22 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Peritracheal Tissue, Inflammation, | | |
Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 3 |
Cornea, Inflammation, Chronic | | 3 1.3|
__________________________________________________________________________|____________|
Harderian Gland | | 6 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Congestion | | 1 3.0|
Hydronephrosis | | 2 2.5|
Inflammation | | 2 3.0|
Nephropathy | 2 1 2 1 2 2 1 2 2 1 1 2 1 1 2 2 1 2 4 2 1 1 2| 93 1.8|
Glomerulus, Amyloid Deposition | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 98 |
Atrophy | | 1 1.0|
Inflammation, Chronic | 2 | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------