TDMS Study 88070-03 Pathology Tables
NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/11/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43
CORE STUDY
Facility: Battelle Northwest
Chemical CAS #: 115-11-0007
Lock Date: 10/05/95
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/11/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 6| 6| 7| 4| 4| 4| 7| 7| 5| 5| 5| 7| 7| 7| 7| 4| 7| 4| 7|
DAY ON TEST | 3| 3| 3| 2| 7| 1| 6| 4| 3| 8| 9| 4| 3| 3| 8| 5| 2| 3| 0| 3| 3| 2| 3| 8| 3|
| 3| 3| 3| 0| 3| 4| 3| 2| 3| 8| 6| 0| 3| 4| 1| 2| 9| 4| 5| 4| 4| 1| 4| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 4 |
Parasite Metazoan | X X X X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X |
Degeneration, Fatty | 3 2 3 2 1 3 2 |
Eosinophilic Focus | X X |
Hepatodiaphragmatic Nodule | X |
Inflammation, Granulomatous | |
Mixed Cell Focus | X X X X |
Necrosis | 2 2 |
Regeneration | |
Thrombosis | 2 |
Bile Duct, Hyperplasia | 2 2 2 2 |
Centrilobular, Necrosis | 2 1 1 |
__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Hemorrhage | 1 |
Fat, Necrosis | 2 2 2 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 2 1 1 |
Basophilic Focus | X |
Metaplasia, Hepatocyte | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Mineralization | |
Necrosis | 4 3 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 2 1 1 1 1 1 2 1 2 2 2 1 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/11/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 6| 6| 7| 4| 4| 4| 7| 7| 5| 5| 5| 7| 7| 7| 7| 4| 7| 4| 7|
DAY ON TEST | 3| 3| 3| 2| 7| 1| 6| 4| 3| 8| 9| 4| 3| 3| 8| 5| 2| 3| 0| 3| 3| 2| 3| 8| 3|
| 3| 3| 3| 0| 3| 4| 3| 2| 3| 8| 6| 0| 3| 4| 1| 2| 9| 4| 5| 4| 4| 1| 4| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
Hyperplasia | 2 2 2 2 1 |
Hypertrophy | 2 2 1 1 2 3 |
Necrosis | 2 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 3 1 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 2 1 1 2 1 1 2 3 2 2 1 1 1 2 3 2 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 3 2 2 3 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
__________________________________________________________________________|
Lymph Node | + + + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + M + + + + M + M + + + M M + + M + M + M +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + M + M + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + M + + + + + M + + + + + + + M + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 4 |
Hemorrhage | 2 |
Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 3 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/11/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 6| 6| 7| 4| 4| 4| 7| 7| 5| 5| 5| 7| 7| 7| 7| 4| 7| 4| 7|
DAY ON TEST | 3| 3| 3| 2| 7| 1| 6| 4| 3| 8| 9| 4| 3| 3| 8| 5| 2| 3| 0| 3| 3| 2| 3| 8| 3|
| 3| 3| 3| 0| 3| 4| 3| 2| 3| 8| 6| 0| 3| 4| 1| 2| 9| 4| 5| 4| 4| 1| 4| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 1 2 2 2 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | 1 2 |
Alveolar Epithelium, Hyperplasia | 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 1 1 2 |
Thrombosis | 3 2 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 2 1 1 2 2 1 1 1 2 2 2 1 2 2 1 1 1 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Cataract | 2 3 3 |
Retina, Atrophy | 3 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 2 |
Nephropathy | 3 2 2 1 1 2 1 1 3 1 2 1 2 1 2 3 2 2 1 3 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/11/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 7| 5| 7| 6| 7| 7| 6| |
DAY ON TEST | 9| 3| 4| 1| 3| 2| 2| 3| 3| 3| 3| 6| 7| 3| 3| 3| 2| 9| 3| 5| 0| 0| 3| 3| 4| |
| 1| 4| 2| 5| 4| 2| 6| 4| 4| 4| 4| 4| 8| 5| 5| 5| 0| 0| 5| 2| 5| 8| 5| 5| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X X X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A A + + + + + + + + + + + + + + + + + + + I +| 47 |
Parasite Metazoan | X X X | 8 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A A + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Acute | | 1 4.0|
Parasite Metazoan | X | 5 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A A + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A A + + + + + + + + + + + + + + + + A + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X | 36 |
Clear Cell Focus | X X X X | 6 |
Degeneration, Fatty | 3 2 2 2 2| 12 2.3|
Eosinophilic Focus | X X X X | 6 |
Hepatodiaphragmatic Nodule | X X X | 4 |
Inflammation, Granulomatous | 1 | 1 1.0|
Mixed Cell Focus | X X X | 7 |
Necrosis | | 2 2.0|
Regeneration | 4 | 1 4.0|
Thrombosis | | 1 2.0|
Bile Duct, Hyperplasia | 2 2 2 2 1| 9 1.9|
Centrilobular, Necrosis | 2 | 4 1.5|
__________________________________________________________________________|____________|
Mesentery | + + + | 8 |
Fat, Hemorrhage | | 1 1.0|
Fat, Necrosis | 2 2 2 | 8 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 2 2 | 9 1.7|
Basophilic Focus | | 1 |
Metaplasia, Hepatocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | | 1 2.0|
Mineralization | 1 | 1 1.0|
Necrosis | 2 1 3| 7 2.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 2 | 3 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 5
NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/11/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 7| 5| 7| 6| 7| 7| 6| |
DAY ON TEST | 9| 3| 4| 1| 3| 2| 2| 3| 3| 3| 3| 6| 7| 3| 3| 3| 2| 9| 3| 5| 0| 0| 3| 3| 4| |
| 1| 4| 2| 5| 4| 2| 6| 4| 4| 4| 4| 4| 8| 5| 5| 5| 0| 0| 5| 2| 5| 8| 5| 5| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 1 2 1 1 2 2 2 1 2 2 2 2 1 | 30 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 2 2 | 2 2.0|
Hyperplasia | 2 2 1 2 2 2 2 2 2 2 | 15 1.9|
Hypertrophy | 1 2 1 2 2 | 11 1.7|
Necrosis | | 2 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 3 2 2 | 10 1.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Hyperplasia | 1 3 2 3| 7 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 2 1 2 3 1 1 1 2 2 1 1 2 2 1 2| 37 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 2 2 | 9 2.3|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 6 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + M + M + M + + + + + + M + M + + + + +| 36 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + M + + + + + + + + + + + + + + M + +| 44 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + M M + M + + + + + M + +| 42 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/11/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 7| 5| 7| 6| 7| 7| 6| |
DAY ON TEST | 9| 3| 4| 1| 3| 2| 2| 3| 3| 3| 3| 6| 7| 3| 3| 3| 2| 9| 3| 5| 0| 0| 3| 3| 4| |
| 1| 4| 2| 5| 4| 2| 6| 4| 4| 4| 4| 4| 8| 5| 5| 5| 0| 0| 5| 2| 5| 8| 5| 5| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 3 | 5 3.2|
Hemorrhage | | 1 2.0|
Necrosis | 2| 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 2 | 2 2.5|
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 3 | 1 3.0|
Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 1 2 3 3 | 9 1.9|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Granulomatous | 1 2 1 1 1 | 7 1.3|
Alveolar Epithelium, Hyperplasia | 2 1 2 1 1 | 9 1.2|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 1 | 7 1.3|
Thrombosis | | 2 2.5|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 2 1 1 2 1 2 2 2 2 1 2 1 2 2 1 1 2 1 1 1 1 2| 44 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | +| 4 |
Cataract | 4| 4 3.0|
Retina, Atrophy | 4| 3 3.3|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/11/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 7| 5| 7| 6| 7| 7| 6| |
DAY ON TEST | 9| 3| 4| 1| 3| 2| 2| 3| 3| 3| 3| 6| 7| 3| 3| 3| 2| 9| 3| 5| 0| 0| 3| 3| 4| |
| 1| 4| 2| 5| 4| 2| 6| 4| 4| 4| 4| 4| 8| 5| 5| 5| 0| 0| 5| 2| 5| 8| 5| 5| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | | 1 2.0|
Nephropathy | 1 1 2 2 3 3 2 3 2 2 2 1 1 3 2 1 2 1 2 2 2 2 2 2 2| 46 1.9|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/11/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 0| 7| 7| 7| 6| 7| 4| 7| 6| 7| 7| 5| 6| 4| 6| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 9| 4| 2| 0| 1| 3| 3| 1| 6| 3| 4| 3| 0| 3| 3| 6| 0| 9| 8| 3| 9| 8| 6| 3| 3|
| 6| 8| 2| 8| 3| 3| 3| 9| 2| 3| 0| 3| 8| 4| 4| 5| 3| 4| 8| 4| 2| 8| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + I I + + I + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + A + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + A + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X |
Degeneration, Fatty | 2 2 1 3 2 2 |
Eosinophilic Focus | X X X |
Hepatodiaphragmatic Nodule | X X X X X X|
Mitotic Alteration | |
Mixed Cell Focus | X X X X |
Regeneration | 3 |
Bile Duct, Hyperplasia | 1 3 2 |
Centrilobular, Necrosis | 3 2 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + |
Fat, Necrosis | 2 3 3 3 2 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 1 |
Basophilic Focus | X X |
Hyperplasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Basal Cell | 2|
Necrosis | 2 4 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 2 2 1 1 1 1 1 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/11/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 0| 7| 7| 7| 6| 7| 4| 7| 6| 7| 7| 5| 6| 4| 6| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 9| 4| 2| 0| 1| 3| 3| 1| 6| 3| 4| 3| 0| 3| 3| 6| 0| 9| 8| 3| 9| 8| 6| 3| 3|
| 6| 8| 2| 8| 3| 3| 3| 9| 2| 3| 0| 3| 8| 4| 4| 5| 3| 4| 8| 4| 2| 8| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Degeneration, Cystic | 2 |
Hyperplasia | 3 2 1 2 2 1 |
Hypertrophy | 1 2 1 |
Thrombosis | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia | 3 4 3 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 3 2 2 2 2 3 2 2 2 2 1 2 2 1|
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + I + + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 4 1 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cervix, Hypertrophy | |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1|
__________________________________________________________________________|
Lymph Node | + + |
Pancreatic, Ectasia | |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + M + + + + + M M M M + + M + + M M M M + M|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + M + + + + + + + + + + + M +|
Infiltration Cellular, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + M + + + + + + + + + + + + + + M M +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X |
Fibrosis | 1 2 |
Hematopoietic Cell Proliferation | 2 |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/11/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 0| 7| 7| 7| 6| 7| 4| 7| 6| 7| 7| 5| 6| 4| 6| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 9| 4| 2| 0| 1| 3| 3| 1| 6| 3| 4| 3| 0| 3| 3| 6| 0| 9| 8| 3| 9| 8| 6| 3| 3|
| 6| 8| 2| 8| 3| 3| 3| 9| 2| 3| 0| 3| 8| 4| 4| 5| 3| 4| 8| 4| 2| 8| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 1 3 1 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | 1 |
Inflammation, Suppurative | 3 |
Alveolar Epithelium, Hyperplasia | 1 1 2 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
Thrombosis | 3 1 4 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 3 3 3 2 3 3 3 2 2 3 3 3 3 2 2 2 3 3 2 3 2 2 2|
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + |
Cataract | 3 3 |
Retina, Atrophy | 3 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 2 1 2 1 2 1 2 2 1 3 2 1 2 2 2 1 1 2 3 2 2|
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/11/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 7| 7| 7| 5| 7| 6| 5| 7| 7| 7| 6| 6| 2| 7| 7| 4| 4| 7| 4| 7| 7| |
DAY ON TEST | 3| 1| 3| 8| 3| 3| 1| 7| 3| 3| 3| 0| 1| 3| 2| 3| 1| 3| 3| 2| 7| 3| 5| 3| 3| |
| 4| 6| 4| 0| 4| 4| 8| 3| 4| 0| 4| 1| 4| 4| 1| 5| 6| 4| 5| 0| 9| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Parasite Metazoan | X X X X| 5 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Inflammation, Acute | 4 | 1 4.0|
Parasite Metazoan | X X | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + +| 47 |
Inflammation, Acute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +| 47 |
Inflammation, Acute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 2 1 | 3 1.3|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X| 36 |
Clear Cell Focus | X X X| 9 |
Degeneration, Fatty | 3 1 2 3 | 10 2.1|
Eosinophilic Focus | X X X| 6 |
Hepatodiaphragmatic Nodule | X | 7 |
Mitotic Alteration | 4 | 1 4.0|
Mixed Cell Focus | X X X X X X X| 11 |
Regeneration | | 1 3.0|
Bile Duct, Hyperplasia | 2 1 | 5 1.8|
Centrilobular, Necrosis | | 4 2.3|
__________________________________________________________________________|____________|
Mesentery | + + + | 10 |
Fat, Necrosis | 2 2 2 | 10 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 2 2 2 2 2 1| 11 1.7|
Basophilic Focus | X X | 4 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Basal Cell | | 1 2.0|
Necrosis | 2 1 4 | 7 2.6|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 3 | 2 2.5|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/11/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 7| 7| 7| 5| 7| 6| 5| 7| 7| 7| 6| 6| 2| 7| 7| 4| 4| 7| 4| 7| 7| |
DAY ON TEST | 3| 1| 3| 8| 3| 3| 1| 7| 3| 3| 3| 0| 1| 3| 2| 3| 1| 3| 3| 2| 7| 3| 5| 3| 3| |
| 4| 6| 4| 0| 4| 4| 8| 3| 4| 0| 4| 1| 4| 4| 1| 5| 6| 4| 5| 0| 9| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 2 1 1 1 1 2 1 1 2 1 1 2 1 2 1 | 29 1.4|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 | 1 4.0|
Degeneration, Cystic | 2 | 2 2.0|
Hyperplasia | 2 2 2 2 2 2 2 2 2 2| 17 1.9|
Hypertrophy | 2 2 2 2 2| 8 1.8|
Thrombosis | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 5 2.2|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
Pars Distalis, Angiectasis | 3 | 1 3.0|
Pars Distalis, Hyperplasia | 3 2 2 | 7 2.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 2 2 1 2 1 2 3 1 1 1 1 1 1 1 2 1| 34 1.6|
Follicular Cell, Hyperplasia | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 4 2.8|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cervix, Hypertrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Vagina | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | + | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/11/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 7| 7| 7| 5| 7| 6| 5| 7| 7| 7| 6| 6| 2| 7| 7| 4| 4| 7| 4| 7| 7| |
DAY ON TEST | 3| 1| 3| 8| 3| 3| 1| 7| 3| 3| 3| 0| 1| 3| 2| 3| 1| 3| 3| 2| 7| 3| 5| 3| 3| |
| 4| 6| 4| 0| 4| 4| 8| 3| 4| 0| 4| 1| 4| 4| 1| 5| 6| 4| 5| 0| 9| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pancreatic, Ectasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + M + M + M M M + + M + + M + +| 31 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + + + + +| 46 |
Infiltration Cellular, Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + M + + + + + + + + + M + + + +| 45 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | | 1 |
Fibrosis | 2 | 3 1.7|
Hematopoietic Cell Proliferation | 4 | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + + + + + M + + M + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 3 3 2 | 7 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Granulomatous | 1 1 1 1| 5 1.0|
Inflammation, Suppurative | | 1 3.0|
Alveolar Epithelium, Hyperplasia | 2 3 1 1 1| 9 1.4|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 | 2 1.5|
Thrombosis | | 3 2.7|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 2 2 2 2 2 2 1 2 2 3 3 3 2 2 2 3 2 2 3 2 3 3| 47 2.4|
Respiratory Epithelium, Metaplasia, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/11/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 7| 7| 7| 5| 7| 6| 5| 7| 7| 7| 6| 6| 2| 7| 7| 4| 4| 7| 4| 7| 7| |
DAY ON TEST | 3| 1| 3| 8| 3| 3| 1| 7| 3| 3| 3| 0| 1| 3| 2| 3| 1| 3| 3| 2| 7| 3| 5| 3| 3| |
| 4| 6| 4| 0| 4| 4| 8| 3| 4| 0| 4| 1| 4| 4| 1| 5| 6| 4| 5| 0| 9| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Squamous | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + | 4 |
Cataract | 4 | 3 3.3|
Retina, Atrophy | 4 | 3 3.3|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy | 1 2 2 2 3 2 2 1 2 2 1 2 2 2 2 1 1 2 1 2 2 1 2 2| 46 1.7|
Renal Tubule, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/11/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 3| 0| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 0| 3|
| 3| 1| 2| 3| 3| 3| 6| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 7| 5| 0| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + A +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + I + + + I + + + + +|
Parasite Metazoan | X X|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + A A +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + A A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + M A +|
Necrosis | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 2 1 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X |
Degeneration, Cystic | |
Degeneration, Fatty | 2 3 3 3 1 |
Eosinophilic Focus | X X |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X X |
Mixed Cell Focus | X 3 X X|
Necrosis | 2 |
Regeneration | 2 3 |
Bile Duct, Hyperplasia | 1 2 2 |
Centrilobular, Necrosis | 1 1 1 |
__________________________________________________________________________|
Mesentery | + + + + + + + + |
Thrombosis | |
Fat, Necrosis | 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + A +|
Atrophy | 2 1 2 1 1 1 2 1 1 1 |
Basophilic Focus | X |
Hyperplasia | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 1 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
Necrosis | |
__________________________________________________________________________|
Tooth | |
Necrosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + A +|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/11/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 3| 0| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 0| 3|
| 3| 1| 2| 3| 3| 3| 6| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 7| 5| 0| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 2 2 1 1 1 2 2 2 2 2 1 2 2 2 2 2 1 2 1 2|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + A +|
Degeneration, Cystic | 2 2 3 |
Hyperplasia | 2 2 2 2 2 2 2 2 2 2 1 |
Hypertrophy | 1 2 2 2 3 2 |
Necrosis | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + A +|
Hyperplasia | 2 1 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Pars Distalis, Hyperplasia | 1 2 2 1 2 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + A +|
C-Cell, Hyperplasia | 1 1 2 3 2 1 1 2 1 2 1 2 3 1 2 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Hyperplasia | 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 3 3 |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + A +|
Hyperplasia, Reticulum Cell | |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + M + + + + + + + + + + + + + M M + M + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + M +|
Infiltration Cellular, Plasma Cell | 4 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + M + + + M + + + M M + + + + M M|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + A +|
Fibrosis | 2 2 2 |
Hematopoietic Cell Proliferation | 2 4 4|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/11/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 3| 0| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 0| 3|
| 3| 1| 2| 3| 3| 3| 6| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 7| 5| 0| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + M + + + + M + + + + + + + + M + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | |
Inflammation, Acute | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia | 1 2 1 1 |
Bronchiole, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 2 1 1 1 |
Thrombosis | 2 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 3 3 3 3 4 2 3 2 3 3 3 3 3 3 2 3 3 2 2 3 2 3 3|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + +|
Cataract | 3 4 3 4|
Retina, Atrophy | 4 4 4 3|
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + A +|
Nephropathy | 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 1 2 3 2 2 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + A +|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/11/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 6| 7| 7| 7| 6| 5| 7| 7| 6| 5| 7| 7| 5| |
DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 3| 8| 8| 9| 4| 3| 3| 3| 8| 6| 2| 3| 5| 5| 3| 3| 3| |
| 6| 5| 5| 5| 5| 5| 5| 5| 5| 4| 0| 9| 4| 5| 5| 5| 6| 0| 0| 5| 1| 2| 5| 5| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + I + + + + + + + + + + + + + + + + + + + + +| 47 |
Parasite Metazoan | X X X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | X X | 4 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 4 1.5|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X | 43 |
Clear Cell Focus | X X X X X X X X | 12 |
Degeneration, Cystic | 4 2 | 2 3.0|
Degeneration, Fatty | 3 1 2 2 3 2 2| 12 2.3|
Eosinophilic Focus | X X X| 5 |
Hematopoietic Cell Proliferation | | 1 1.0|
Hepatodiaphragmatic Nodule | X X X | 5 |
Mixed Cell Focus | X X X X X | 9 3.0|
Necrosis | 1 | 2 1.5|
Regeneration | | 2 2.5|
Bile Duct, Hyperplasia | 2 1 2 2| 7 1.7|
Centrilobular, Necrosis | 1 1 | 5 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 12 |
Thrombosis | 3 | 1 3.0|
Fat, Necrosis | 2 2 2 3 | 12 2.1|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 1 4 2 1 2 2 3| 17 1.6|
Basophilic Focus | X X | 3 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 3 1 2 | 6 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 1.0|
Necrosis | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/11/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 6| 7| 7| 7| 6| 5| 7| 7| 6| 5| 7| 7| 5| |
DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 3| 8| 8| 9| 4| 3| 3| 3| 8| 6| 2| 3| 5| 5| 3| 3| 3| |
| 6| 5| 5| 5| 5| 5| 5| 5| 5| 4| 0| 9| 4| 5| 5| 5| 6| 0| 0| 5| 1| 2| 5| 5| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tooth | + | 1 |
Necrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cardiomyopathy | 2 1 2 2 2 1 2 3 1 2 2 1 2 2 2 2 2 | 37 1.8|
Atrium, Thrombosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Cystic | 2 | 4 2.3|
Hyperplasia | 3 2 2 2 2 2 2 2 2 2 2 1 2 | 24 2.0|
Hypertrophy | 2 1 2 | 9 1.9|
Necrosis | 3 2 | 3 2.7|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 | 6 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Pars Distalis, Hyperplasia | 3 4 2 4 2 | 11 2.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 2 1 2 2 2 1 1 1 2 1 1 2 1 1 2 1 3 2 1 1 1 1 | 38 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + M + M + + +| 47 |
Hyperplasia | 3 3 3 3 | 5 2.8|
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 4 2.5|
Inflammation, Granulomatous | 1 | 1 1.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/11/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 6| 7| 7| 7| 6| 5| 7| 7| 6| 5| 7| 7| 5| |
DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 3| 8| 8| 9| 4| 3| 3| 3| 8| 6| 2| 3| 5| 5| 3| 3| 3| |
| 6| 5| 5| 5| 5| 5| 5| 5| 5| 4| 0| 9| 4| 5| 5| 5| 6| 0| 0| 5| 1| 2| 5| 5| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Reticulum Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + +| 3 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + M M M M + + + + M + + M M + + M + + + +| 36 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + M + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Plasma Cell | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M + + + + + M + M M + + + + + + + + + M + + +| 39 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrosis | 2 1 2 | 6 1.8|
Hematopoietic Cell Proliferation | | 3 3.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + M + + + + + + + +| 45 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 2 | 1 2.0|
Inflammation, Acute | 4 | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | 2 | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 2 3 2 3 3 3| 11 2.4|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Granulomatous | 1 1 1 1| 9 1.0|
Alveolar Epithelium, Hyperplasia | 3 1 1 | 7 1.4|
Bronchiole, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 2 3 | 8 1.5|
Thrombosis | 4 | 2 3.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 2 3 3 3 3 2 3 3 2 2 2 3 3 3 3 3 3 2 3 3 3 3 3 4| 48 2.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/11/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 6| 7| 7| 7| 6| 5| 7| 7| 6| 5| 7| 7| 5| |
DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 3| 8| 8| 9| 4| 3| 3| 3| 8| 6| 2| 3| 5| 5| 3| 3| 3| |
| 6| 5| 5| 5| 5| 5| 5| 5| 5| 4| 0| 9| 4| 5| 5| 5| 6| 0| 0| 5| 1| 2| 5| 5| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 6 |
Cataract | 3 3 | 6 3.3|
Retina, Atrophy | 3 4 | 6 3.7|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Nephropathy | 2 2 2 1 2 2 2 2 2 3 2 2 2 2 2 2 2 1 1 2 2 3 2| 46 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/11/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 7| 7| 5| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 4| 5|
DAY ON TEST | 6| 0| 5| 3| 2| 3| 2| 9| 3| 6| 4| 3| 3| 7| 3| 3| 3| 3| 0| 3| 3| 0| 6| 0| 8|
| 4| 6| 0| 3| 8| 3| 9| 7| 3| 3| 7| 3| 0| 4| 4| 4| 4| 4| 0| 4| 4| 2| 8| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
8000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + I + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + A A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A A +|
Parasite Metazoan | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X |
Cytomegaly | |
Degeneration, Fatty | 2 3 3 3 1 1|
Eosinophilic Focus | X X X X X X X |
Hepatodiaphragmatic Nodule | X X |
Mixed Cell Focus | X X X X X |
Regeneration | 4 3 |
Bile Duct, Hyperplasia | 2 3 1 1 |
Centrilobular, Necrosis | 1 2 4 2 |
__________________________________________________________________________|
Mesentery | + + + |
Artery, Inflammation, Chronic Active | 3 |
Fat, Necrosis | 2 2 2 |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 1 1 1 1 |
Basophilic Focus | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 3 2 2 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 |
__________________________________________________________________________|
Tongue | |
Hyperplasia, Squamous | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 1 2 1 1 1 2 1 1 2 1 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/11/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 7| 7| 5| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 4| 5|
DAY ON TEST | 6| 0| 5| 3| 2| 3| 2| 9| 3| 6| 4| 3| 3| 7| 3| 3| 3| 3| 0| 3| 3| 0| 6| 0| 8|
| 4| 6| 0| 3| 8| 3| 9| 7| 3| 3| 7| 3| 0| 4| 4| 4| 4| 4| 0| 4| 4| 2| 8| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
8000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
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ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Degeneration, Cystic | |
Hyperplasia | 2 3 2 2 2 2 2 1 3 2 1 |
Hypertrophy | 2 2 2 2 |
Necrosis | |
Vacuolization Cytoplasmic | |
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Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 4 |
Pars Distalis, Cyst | 4|
Pars Distalis, Hyperplasia | 2 2 3|
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Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 2 2 1 1 1 2 1 1 1 1 1 2 1 1|
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GENERAL BODY SYSTEM | |
| |
None | |
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GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Necrosis | 4|
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Vagina | + |
Inflammation, Suppurative | 3 |
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HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Hyperplasia, Histiocytic | |
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Lymph Node |