TDMS Study 88120-03 Pathology Tables
NTP Experiment-Test: 88120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:45:07
FINAL #1 CORE STUDY RATS
Facility: Battelle Columbus Laboratory
Chemical CAS #: 80-07-9
Lock Date: 08/11/98
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:45:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 30 PPM 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 11 9 12 5
Natural Death 3 3 3 10
Survivors
Terminal Sacrifice 36 38 34 35
Natural Death 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (50) (50) (50)
Parasite Metazoan 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Intestine Large, Rectum (50) (50) (50) (50)
Parasite Metazoan 8 (16%) 4 (8%) 3 (6%) 4 (8%)
Intestine Large, Cecum (50) (49) (50) (50)
Inflammation 1 (2%)
Intestine Small, Duodenum (50) (50) (50) (50)
Ulcer 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 1 (2%) 1 (2%) 2 (4%)
Basophilic Focus 47 (94%) 48 (96%) 43 (86%) 36 (72%)
Clear Cell Focus 2 (4%) 5 (10%) 1 (2%) 2 (4%)
Eosinophilic Focus 9 (18%) 10 (20%) 14 (28%) 7 (14%)
Fatty Change 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Hepatodiaphragmatic Nodule 9 (18%) 11 (22%) 12 (24%) 14 (28%)
Inflammation 43 (86%) 44 (88%) 39 (78%) 30 (60%)
Mixed Cell Focus 8 (16%) 19 (38%) 7 (14%) 9 (18%)
Necrosis 3 (6%) 1 (2%) 4 (8%)
Pigmentation 1 (2%)
Vacuolization Cytoplasmic 7 (14%) 11 (22%) 9 (18%) 9 (18%)
Bile Duct, Hyperplasia 5 (10%) 12 (24%) 21 (42%) 32 (64%)
Centrilobular, Degeneration 1 (2%) 5 (10%) 10 (20%) 7 (14%)
Centrilobular, Hypertrophy 2 (4%) 24 (48%) 38 (76%)
Mesentery (7) (8) (4) (4)
Inflammation 2 (25%)
Artery, Inflammation 1 (13%) 1 (25%)
Fat, Necrosis 6 (86%) 6 (75%) 4 (100%) 3 (75%)
Pancreas (50) (50) (50) (50)
Atrophy 10 (20%) 8 (16%) 8 (16%) 8 (16%)
Cytoplasmic Alteration 1 (2%) 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:45:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 30 PPM 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation 5 (10%) 2 (4%) 7 (14%) 3 (6%)
Metaplasia, Hepatocyte 1 (2%)
Thrombosis 1 (2%)
Artery, Inflammation 1 (2%) 1 (2%)
Salivary Glands (50) (50) (50) (50)
Atrophy 1 (2%) 1 (2%) 2 (4%)
Cytoplasmic Alteration 1 (2%) 1 (2%) 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Edema 1 (2%)
Hyperplasia 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Inflammation 1 (2%) 1 (2%)
Ulcer 2 (4%)
Stomach, Glandular (50) (50) (50) (50)
Erosion 2 (4%) 1 (2%) 3 (6%)
Inflammation 1 (2%) 1 (2%)
Mineralization 1 (2%) 1 (2%)
Ulcer 3 (6%) 1 (2%) 3 (6%)
Tooth (4)
Inflammation 1 (25%)
Peridontal Tissue, Inflammation 3 (75%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (50)
Inflammation 1 (2%)
Aorta, Inflammation 1 (2%)
Heart (50) (50) (50) (50)
Cardiomyopathy 30 (60%) 23 (46%) 23 (46%) 27 (54%)
Inflammation 5 (10%) 4 (8%) 1 (2%)
Thrombosis 1 (2%) 1 (2%)
Valve, Inflammation 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Accessory Adrenal Cortical Nodule 1 (2%)
Angiectasis 27 (54%) 21 (42%) 26 (52%) 26 (52%)
Degeneration, Cystic 3 (6%) 1 (2%) 2 (4%)
Hyperplasia 14 (28%) 11 (22%) 19 (38%) 18 (36%)
Hypertrophy 4 (8%) 4 (8%) 5 (10%) 3 (6%)
Inflammation 1 (2%)
Necrosis 1 (2%) 2 (4%)
Vacuolization Cytoplasmic 3 (6%) 6 (12%) 5 (10%) 1 (2%)
Adrenal Medulla (50) (49) (50) (50)
Angiectasis 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:45:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 30 PPM 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia 4 (8%) 8 (16%) 3 (6%) 1 (2%)
Pituitary Gland (50) (49) (50) (50)
Angiectasis 19 (38%) 17 (35%) 23 (46%) 21 (42%)
Cyst 4 (8%) 4 (8%) 3 (6%)
Pars Distalis, Hyperplasia 23 (46%) 28 (57%) 23 (46%) 24 (48%)
Pars Intermedia, Hyperplasia 1 (2%)
Pars Nervosa, Hyperplasia 1 (2%)
Thyroid Gland (50) (50) (50) (50)
Angiectasis 1 (2%)
Cyst 1 (2%)
C-Cell, Hyperplasia 35 (70%) 38 (76%) 34 (68%) 23 (46%)
Follicular Cell, Hyperplasia 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (47) (50) (50) (48)
Hyperplasia 6 (13%) 6 (12%) 6 (12%) 3 (6%)
Inflammation 16 (34%) 17 (34%) 21 (42%) 18 (38%)
Duct, Cyst 3 (6%) 5 (10%) 2 (4%) 3 (6%)
Ovary (50) (50) (50) (50)
Atrophy 2 (4%) 2 (4%) 1 (2%)
Cyst 3 (6%) 7 (14%) 3 (6%) 2 (4%)
Infiltration Cellular, Histiocyte 2 (4%) 3 (6%) 1 (2%)
Inflammation 1 (2%)
Uterus (50) (50) (50) (50)
Atrophy 1 (2%)
Dilatation 1 (2%)
Hemorrhage 1 (2%)
Hydrometra 2 (4%) 4 (8%)
Hyperplasia 1 (2%)
Inflammation 1 (2%) 1 (2%)
Cervix, Cyst, Squamous 1 (2%) 1 (2%)
Cervix, Hydrometra 1 (2%)
Cervix, Hyperplasia, Squamous 1 (2%)
Cervix, Inflammation 1 (2%) 1 (2%) 2 (4%)
Endometrium, Adenomyosis 1 (2%)
Endometrium, Hyperplasia, Cystic 3 (6%) 7 (14%) 7 (14%) 6 (12%)
Vagina (2)
Hyperplasia 1 (50%)
Inflammation 2 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:45:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 30 PPM 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Atrophy 1 (2%)
Hyperplasia 9 (18%) 12 (24%) 8 (16%) 12 (24%)
Inflammation, Granulomatous 2 (4%)
Myelofibrosis 1 (2%)
Lymph Node (27) (23) (28) (28)
Mediastinal, Congestion 1 (4%)
Mediastinal, Ectasia 1 (4%)
Mediastinal, Hyperplasia, Plasma Cell 1 (4%)
Mediastinal, Pigmentation 26 (96%) 19 (83%) 26 (93%) 24 (86%)
Lymph Node, Mandibular (49) (50) (48) (50)
Ectasia 1 (2%) 8 (16%) 5 (10%) 5 (10%)
Hyperplasia, Plasma Cell 4 (8%) 1 (2%) 5 (10%)
Lymph Node, Mesenteric (50) (50) (50) (50)
Atrophy 1 (2%) 1 (2%) 1 (2%)
Hyperplasia, Plasma Cell 1 (2%)
Spleen (50) (50) (50) (50)
Accessory Spleen 1 (2%)
Fibrosis 2 (4%) 1 (2%)
Hematopoietic Cell Proliferation 3 (6%) 4 (8%) 7 (14%) 2 (4%)
Infarct 1 (2%)
Pigmentation 25 (50%) 26 (52%) 28 (56%) 32 (64%)
Capsule, Fibrosis 1 (2%)
Lymphoid Follicle, Atrophy 1 (2%) 1 (2%) 3 (6%)
Thymus (46) (48) (50) (48)
Atrophy 46 (100%) 46 (96%) 47 (94%) 48 (100%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Cyst 1 (2%) 1 (2%)
Dilatation 2 (4%)
Galactocele 1 (2%) 6 (12%) 1 (2%)
Hyperplasia 14 (28%) 19 (38%) 20 (40%) 10 (20%)
Skin (50) (50) (50) (49)
Inflammation 1 (2%)
Ulcer 2 (4%)
Subcutaneous Tissue, Inflammation 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:45:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 30 PPM 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Osteopetrosis 2 (4%) 2 (4%) 6 (12%) 4 (8%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Hemorrhage 2 (4%) 1 (2%)
Inflammation 1 (2%)
Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Edema 1 (2%)
Hemorrhage 1 (2%) 1 (2%) 1 (2%)
Inflammation 23 (46%) 21 (42%) 23 (46%) 31 (62%)
Necrosis 2 (4%)
Pigmentation 40 (80%) 40 (80%) 42 (84%) 35 (70%)
Thrombosis 1 (2%) 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia 8 (16%) 7 (14%) 9 (18%) 9 (18%)
Bronchiole, Hyperplasia 1 (2%)
Mediastinum, Thrombosis 1 (2%)
Serosa, Inflammation 1 (2%)
Nose (50) (50) (50) (50)
Foreign Body 2 (4%) 1 (2%)
Inflammation 3 (6%) 2 (4%) 4 (8%) 4 (8%)
Nasolacrimal Duct, Inflammation 1 (2%)
Trachea (50) (50) (50) (50)
Inflammation 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (3) (2) (4)
Atrophy 1 (25%)
Cataract 1 (33%) 2 (100%) 3 (75%)
Hemorrhage 1 (33%) 1 (25%)
Cornea, Edema 1 (25%)
Retina, Degeneration 1 (33%) 2 (100%) 3 (75%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:45:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 30 PPM 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Glomerulosclerosis 1 (2%)
Hydronephrosis 1 (2%) 1 (2%)
Infarct 1 (2%)
Inflammation 1 (2%) 1 (2%) 1 (2%) 2 (4%)
Nephropathy 39 (78%) 43 (86%) 42 (84%) 42 (84%)
Pigmentation 5 (10%) 2 (4%) 9 (18%) 9 (18%)
Vacuolization Cytoplasmic 1 (2%)
Pelvis, Inflammation 2 (4%) 1 (2%)
Renal Tubule, Hyperplasia 1 (2%)
Urinary Bladder (50) (50) (50) (50)
Calculus Gross Observation 1 (2%)
Calculus Micro Observation Only 1 (2%)
Serosa, Fibrosis 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:45:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 10 PPM 30 PPM 100 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 19 16 24 15
Natural Death 7 4 6 7
Survivors
Terminal Sacrifice 24 30 20 28
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (50) (50) (50)
Parasite Metazoan 1 (2%) 4 (8%) 1 (2%) 2 (4%)
Intestine Large, Rectum (50) (50) (50) (50)
Inflammation 2 (4%)
Parasite Metazoan 3 (6%) 6 (12%) 8 (16%) 7 (14%)
Ulcer 1 (2%)
Intestine Large, Cecum (49) (50) (50) (50)
Hemorrhage 1 (2%)
Inflammation 1 (2%)
Ulcer 1 (2%)
Intestine Small, Jejunum (50) (50) (50) (50)
Ulcer 1 (2%)
Intestine Small, Ileum (50) (50) (50) (50)
Inflammation 1 (2%) 1 (2%)
Parasite Metazoan 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 1 (2%)
Basophilic Focus 30 (60%) 29 (58%) 26 (52%) 27 (54%)
Clear Cell Focus 6 (12%) 11 (22%) 2 (4%) 4 (8%)
Degeneration, Cystic 5 (10%) 4 (8%) 4 (8%) 6 (12%)
Eosinophilic Focus 6 (12%) 8 (16%) 6 (12%) 8 (16%)
Fibrosis 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Hemorrhage 1 (2%) 1 (2%) 1 (2%)
Hepatodiaphragmatic Nodule 7 (14%) 5 (10%) 10 (20%) 4 (8%)
Inflammation 18 (36%) 27 (54%) 19 (38%) 21 (42%)
Mixed Cell Focus 7 (14%) 17 (34%) 8 (16%) 11 (22%)
Necrosis 4 (8%) 1 (2%) 3 (6%) 4 (8%)
Pigmentation 2 (4%)
Thrombosis 1 (2%) 2 (4%)
Vacuolization Cytoplasmic 9 (18%) 4 (8%) 2 (4%) 5 (10%)
Bile Duct, Hyperplasia 46 (92%) 47 (94%) 44 (88%) 48 (96%)
Centrilobular, Degeneration 18 (36%) 15 (30%) 20 (40%) 23 (46%)
Centrilobular, Hypertrophy 1 (2%) 3 (6%) 16 (32%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:45:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 10 PPM 30 PPM 100 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Centrilobular, Necrosis 1 (2%) 1 (2%) 1 (2%)
Mesentery (7) (12) (12) (14)
Hemorrhage 1 (8%) 1 (8%)
Inflammation 1 (8%) 1 (8%)
Necrosis 1 (14%)
Fat, Inflammation 1 (14%) 1 (8%) 2 (14%)
Fat, Necrosis 3 (43%) 7 (58%) 8 (67%) 7 (50%)
Pancreas (50) (50) (50) (50)
Atrophy 14 (28%) 14 (28%) 13 (26%) 12 (24%)
Cytoplasmic Alteration 2 (4%) 2 (4%) 1 (2%)
Hyperplasia 3 (6%) 2 (4%) 2 (4%)
Inflammation 1 (2%) 4 (8%) 4 (8%) 2 (4%)
Necrosis 1 (2%)
Thrombosis 1 (2%)
Artery, Inflammation 2 (4%)
Duct, Cyst 1 (2%) 1 (2%)
Duct, Hyperplasia 1 (2%)
Salivary Glands (50) (50) (50) (50)
Atrophy 1 (2%) 1 (2%)
Cytoplasmic Alteration 1 (2%) 2 (4%)
Duct, Hyperplasia 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Edema 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Hyperplasia 2 (4%) 2 (4%) 1 (2%)
Inflammation 1 (2%) 1 (2%)
Ulcer 2 (4%) 3 (6%) 2 (4%)
Stomach, Glandular (50) (50) (50) (50)
Edema 1 (2%)
Erosion 2 (4%) 1 (2%) 4 (8%) 3 (6%)
Hyperplasia 1 (2%)
Mineralization 1 (2%) 1 (2%)
Necrosis 1 (2%)
Ulcer 2 (4%) 2 (4%) 4 (8%) 2 (4%)
Tooth (1) (1)
Gingiva, Inflammation 1 (100%)
Peridontal Tissue, Inflammation 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (50)
Inflammation 1 (2%)
Aorta, Inflammation 1 (2%)
Heart (50) (50) (50) (50)
Cardiomyopathy 39 (78%) 46 (92%) 43 (86%) 43 (86%)
Inflammation 1 (2%)
Thrombosis 1 (2%) 5 (10%) 5 (10%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:45:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 10 PPM 30 PPM 100 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - CONT
Artery, Inflammation 1 (2%)
Endocardium, Degeneration 1 (2%)
Epicardium, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Angiectasis 2 (4%) 1 (2%) 2 (4%) 1 (2%)
Atrophy 1 (2%)
Degeneration, Cystic 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 11 (22%) 13 (26%) 8 (16%) 9 (18%)
Hypertrophy 3 (6%) 7 (14%) 3 (6%) 2 (4%)
Necrosis 2 (4%)
Vacuolization Cytoplasmic 8 (16%) 6 (12%) 4 (8%) 3 (6%)
Adrenal Medulla (50) (50) (50) (50)
Hemorrhage 1 (2%)
Hyperplasia 14 (28%) 10 (20%) 15 (30%) 12 (24%)
Infiltration Cellular, Lymphocyte 1 (2%)
Islets, Pancreatic (50) (50) (50) (50)
Hyperplasia 1 (2%) 1 (2%)
Parathyroid Gland (46) (48) (47) (46)
Hyperplasia, Focal 1 (2%)
Pituitary Gland (50) (50) (50) (50)
Angiectasis 7 (14%) 6 (12%) 6 (12%) 3 (6%)
Cyst 2 (4%) 8 (16%) 10 (20%) 6 (12%)
Hemorrhage 1 (2%) 2 (4%)
Pars Distalis, Hyperplasia 15 (30%) 17 (34%) 21 (42%) 15 (30%)
Pars Distalis, Pseudocyst 6 (12%) 1 (2%)
Pars Intermedia, Cyst 1 (2%)
Pars Intermedia, Hyperplasia 1 (2%)
Pars Intermedia, Pseudocyst 3 (6%)
Thyroid Gland (50) (50) (50) (50)
Inflammation 1 (2%)
C-Cell, Hyperplasia 19 (38%) 30 (60%) 26 (52%) 20 (40%)
Follicular Cell, Hyperplasia 3 (6%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:45:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 10 PPM 30 PPM 100 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Hyperplasia 1 (2%) 1 (2%)
Inflammation 1 (2%) 1 (2%)
Mesothelium, Hyperplasia 1 (2%) 1 (2%)
Preputial Gland (50) (50) (50) (50)
Hyperplasia 4 (8%) 2 (4%)
Inflammation 46 (92%) 45 (90%) 48 (96%) 48 (96%)
Duct, Cyst 3 (6%) 2 (4%) 2 (4%)
Prostate (50) (50) (50) (50)
Cyst 1 (2%)
Inflammation 27 (54%) 38 (76%) 31 (62%) 29 (58%)
Dorsal, Cyst, Mucous 1 (2%) 1 (2%) 1 (2%)
Seminal Vesicle (50) (50) (50) (50)
Atrophy 1 (2%)
Inflammation 1 (2%) 1 (2%)
Testes (50) (50) (50) (50)
Atrophy 5 (10%) 7 (14%) 3 (6%) 6 (12%)
Cyst 1 (2%)
Hyperplasia 1 (2%)
Artery, Inflammation 1 (2%)
Interstitial Cell, Hyperplasia 28 (56%) 37 (74%) 28 (56%) 24 (48%)
Mesothelium, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hyperplasia 18 (36%) 18 (36%) 16 (32%) 20 (40%)
Inflammation, Granulomatous 1 (2%)
Myelofibrosis 4 (8%) 2 (4%) 1 (2%) 2 (4%)
Necrosis 1 (2%) 1 (2%)
Lymph Node (15) (11) (14) (14)
Inguinal, Hyperplasia, Plasma Cell 1 (9%)
Mediastinal, Atrophy 1 (9%)
Mediastinal, Ectasia 1 (9%)
Mediastinal, Hemorrhage 1 (7%)
Mediastinal, Necrosis 1 (7%)
Mediastinal, Pigmentation 4 (27%) 1 (9%) 4 (29%) 3 (21%)
Pancreatic, Necrosis 1 (9%)
Renal, Hyperplasia, Plasma Cell 1 (7%)
Renal, Necrosis 1 (7%)
Lymph Node, Mandibular (50) (50) (49) (50)
Ectasia 3 (6%) 5 (10%) 3 (6%) 2 (4%)
Hyperplasia, Plasma Cell 4 (8%) 1 (2%)
Necrosis 1 (2%) 1 (2%)
Lymph Node, Mesenteric (50) (50) (50) (49)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:45:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 10 PPM 30 PPM 100 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Atrophy 1 (2%) 1 (2%)
Ectasia 1 (2%) 1 (2%)
Hyperplasia, Reticulum Cell 2 (4%)
Necrosis 1 (2%) 1 (2%)
Spleen (50) (50) (50) (50)
Accessory Spleen 1 (2%) 1 (2%) 2 (4%)
Fibrosis 2 (4%) 4 (8%) 4 (8%) 5 (10%)
Hematopoietic Cell Proliferation 4 (8%) 5 (10%) 3 (6%) 5 (10%)
Hyperplasia, Lymphoid 1 (2%)
Hyperplasia, Reticulum Cell 1 (2%) 1 (2%)
Hyperplasia, Stromal 1 (2%)
Infarct 1 (2%) 1 (2%) 1 (2%)
Infiltration Cellular, Lipocyte 1 (2%)
Necrosis 1 (2%) 1 (2%)
Pigmentation 1 (2%) 2 (4%) 2 (4%) 1 (2%)
Lymphoid Follicle, Atrophy 2 (4%) 3 (6%) 2 (4%)
Thymus (46) (47) (46) (47)
Atrophy 44 (96%) 45 (96%) 40 (87%) 43 (91%)
Artery, Inflammation 1 (2%)
Epithelial Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (47) (50) (48) (50)
Cyst 1 (2%) 1 (2%)
Galactocele 2 (4%)
Hyperplasia 2 (4%) 8 (16%) 9 (19%) 6 (12%)
Inflammation 1 (2%) 1 (2%)
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 1 (2%)
Edema 1 (2%)
Fibrosis 1 (2%)
Hyperkeratosis 1 (2%) 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Inflammation 1 (2%) 1 (2%) 1 (2%)
Ulcer 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Osteopetrosis 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:45:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 10 PPM 30 PPM 100 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Gliosis 1 (2%) 1 (2%)
Hemorrhage 2 (4%) 1 (2%) 4 (8%) 3 (6%)
Necrosis 1 (2%) 4 (8%)
Thrombosis 1 (2%)
Spinal Cord (1)
Hemorrhage 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Edema 1 (2%) 1 (2%)
Foreign Body 1 (2%) 1 (2%) 1 (2%)
Hemorrhage 2 (4%) 3 (6%) 4 (8%)
Inflammation 11 (22%) 16 (32%) 14 (28%) 18 (36%)
Inflammation, Granulomatous 1 (2%)
Necrosis 1 (2%) 1 (2%)
Pigmentation 1 (2%)
Thrombosis 1 (2%) 1 (2%) 2 (4%)
Alveolar Epithelium, Hyperplasia 9 (18%) 7 (14%) 2 (4%) 5 (10%)
Nose (50) (50) (50) (50)
Foreign Body 5 (10%) 6 (12%) 3 (6%) 5 (10%)
Inflammation 12 (24%) 9 (18%) 6 (12%) 8 (16%)
Trachea (50) (50) (50) (50)
Inflammation 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1) (1)
Cataract 1 (100%) 1 (100%)
Retina, Degeneration 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Infarct 1 (2%) 1 (2%) 3 (6%) 1 (2%)
Inflammation 2 (4%)
Necrosis 2 (4%)
Nephropathy 42 (84%) 48 (96%) 41 (82%) 44 (88%)
Pigmentation 13 (26%) 4 (8%) 15 (30%) 19 (38%)
Thrombosis 1 (2%)
Artery, Inflammation 1 (2%)
Pelvis, Inflammation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:45:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 10 PPM 30 PPM 100 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Renal Tubule, Degeneration 1 (2%)
Urethra (1)
Inflammation 1 (100%)
Urinary Bladder (50) (50) (50) (50)
Inflammation 2 (4%)
Transitional Epithelium, Hyperplasia 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------
--multipart-boundary
Content-type: text/plain
Range: bytes 88872-88872/88872
--multipart-boundary--