TDMS Study 88120-03 Pathology Tables
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 FINAL #1 CORE STUDY RATS Facility: Battelle Columbus Laboratory Chemical CAS #: 80-07-9 Lock Date: 08/11/98 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6| DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 6| 5| 4| 3| 3| 3| 3| 3| 9| 2| 3| 3| 2| | 0| 1| 0| 2| 1| 0| 0| 3| 2| 2| 2| 2| 5| 6| 3| 1| 0| 1| 0| 2| 4| 9| 2| 2| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | 2 | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X| Clear Cell Focus | X | Eosinophilic Focus | X X X X X | Fatty Change | 4 | Hemorrhage | | Hepatodiaphragmatic Nodule | X X X X| Inflammation | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1| Mixed Cell Focus | X X | Necrosis | 4 | Vacuolization Cytoplasmic | 1 1 | Bile Duct, Hyperplasia | 1 2 2 | Centrilobular, Degeneration | | __________________________________________________________________________| Mesentery | + + + | Fat, Necrosis | 3 3 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 1 1 1 | Inflammation | 1 1 1 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 | Cytoplasmic Alteration | 1 | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | Inflammation | 1 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | 1 1 | Inflammation | | Ulcer | 1 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1| Inflammation | 1 1 1 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6| DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 6| 5| 4| 3| 3| 3| 3| 3| 9| 2| 3| 3| 2| | 0| 1| 0| 2| 1| 0| 0| 3| 2| 2| 2| 2| 5| 6| 3| 1| 0| 1| 0| 2| 4| 9| 2| 2| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 1 1 1 1 1 1 2 | Degeneration, Cystic | 1 2 | Hyperplasia | 1 1 2 1 1 1 | Hypertrophy | 1 1 | Vacuolization Cytoplasmic | 1 4 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 2 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + M + + + + + M + + + M + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 2 4 2 2 1 2 2 2 3| Cyst | 1 | Pars Distalis, Hyperplasia | 4 1 3 4 2 1 1 3 1 2 1 2| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 | C-Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3 1 1 1 | Follicular Cell, Hyperplasia | 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + M + + M| Hyperplasia | 1 1 2 | Inflammation | 1 1 1 1 1 1 1 1 | Duct, Cyst | 1 3 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Cyst | 3 4 | Inflammation | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydrometra | 2 4 | Cervix, Inflammation | | Endometrium, Hyperplasia, Cystic | 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 4 2 2 3 | Myelofibrosis | 3 | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + +| Mediastinal, Pigmentation | 1 1 1 1 1 2 1 1 1 2 2| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6| DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 6| 5| 4| 3| 3| 3| 3| 3| 9| 2| 3| 3| 2| | 0| 1| 0| 2| 1| 0| 0| 3| 2| 2| 2| 2| 5| 6| 3| 1| 0| 1| 0| 2| 4| 9| 2| 2| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 4 3 | Pigmentation | 2 2 2 1 3 2 1 2 2 1 2| __________________________________________________________________________| Thymus | + + M + + + + + + + + + + + + M + + + + + M + + +| Atrophy | 4 4 3 4 4 4 3 3 3 4 4 4 3 3 3 4 3 3 4 4 3 4| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | | Galactocele | 2 | Hyperplasia | 1 2 2 1 1 1 1 1 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteopetrosis | 4 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 1 1 | __________________________________________________________________________| Peripheral Nerve | + | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 1 1 1 1 1 1 1 1 1 1| Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Alveolar Epithelium, Hyperplasia | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | X | Inflammation | 1 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Cataract | | Hemorrhage | 3 | Retina, Degeneration | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6| DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 6| 5| 4| 3| 3| 3| 3| 3| 9| 2| 3| 3| 2| | 0| 1| 0| 2| 1| 0| 0| 3| 2| 2| 2| 2| 5| 6| 3| 1| 0| 1| 0| 2| 4| 9| 2| 2| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydronephrosis | 2 | Inflammation | 2 | Nephropathy | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Pigmentation | 1 | Pelvis, Inflammation | 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Calculus Micro Observation Only | X | Transitional Epithelium, Hyperplasia | 4 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6| 7| | DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 6| 0| 3| 3| 1| 3| | | 0| 5| 0| 1| 0| 0| 0| 1| 5| 0| 1| 2| 1| 2| 1| 2| 4| 0| 1| 0| 1| 1| 0| 3| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X X X | 8 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ulcer | | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X X X| 47 | Clear Cell Focus | X | 2 | Eosinophilic Focus | X X X X | 9 | Fatty Change | | 1 4.0| Hemorrhage | 2 | 1 2.0| Hepatodiaphragmatic Nodule | X X X X X| 9 | Inflammation | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1| 43 1.0| Mixed Cell Focus | X X X X X X| 8 | Necrosis | 1 2 | 3 2.3| Vacuolization Cytoplasmic | 1 1 2 1 1 | 7 1.1| Bile Duct, Hyperplasia | 1 1| 5 1.4| Centrilobular, Degeneration | 1 | 1 1.0| __________________________________________________________________________|____________| Mesentery | + + + +| 7 | Fat, Necrosis | 3 3 3 3| 6 3.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 1 1 1 1 1 1 | 10 1.0| Inflammation | 1 1 | 5 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 3.0| Cytoplasmic Alteration | | 1 1.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 | 1 2.0| Inflammation | | 1 1.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Erosion | | 2 1.0| Inflammation | 3 | 1 3.0| Ulcer | 3 | 3 1.7| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6| 7| | DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 6| 0| 3| 3| 1| 3| | | 0| 5| 0| 1| 0| 0| 0| 1| 5| 0| 1| 2| 1| 2| 1| 2| 4| 0| 1| 0| 1| 1| 0| 3| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 30 1.0| Inflammation | 1 1 | 5 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 1 2 2 1 1 1 2 1 1 2 1 1 1 2 1 2 1 2 1 | 27 1.3| Degeneration, Cystic | 1 | 3 1.3| Hyperplasia | 1 3 1 1 1 1 1 1 | 14 1.2| Hypertrophy | 2 3 | 4 1.8| Vacuolization Cytoplasmic | 1 | 3 2.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 3 | 4 1.8| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + M + + + + + + + + M + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 3 2 2 2 2 1 2 2 2 | 19 2.1| Cyst | 2 1 1 | 4 1.3| Pars Distalis, Hyperplasia | 2 2 3 2 3 3 1 4 2 2 2| 23 2.2| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 3.0| C-Cell, Hyperplasia | 1 3 4 1 1 1 1 1 1 1 2 1 4 1 1 3 1| 35 1.4| Follicular Cell, Hyperplasia | | 1 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 47 | Hyperplasia | 2 2 2 | 6 1.7| Inflammation | 1 2 4 1 3 1 1 2 | 16 1.4| Duct, Cyst | 3 | 3 2.3| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 4 3 | 2 3.5| Cyst | 3 | 3 3.3| Inflammation | 3 | 1 3.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6| 7| | DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 6| 0| 3| 3| 1| 3| | | 0| 5| 0| 1| 0| 0| 0| 1| 5| 0| 1| 2| 1| 2| 1| 2| 4| 0| 1| 0| 1| 1| 0| 3| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Hydrometra | | 2 3.0| Cervix, Inflammation | 4 | 1 4.0| Endometrium, Hyperplasia, Cystic | 1 2 | 3 1.3| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 3 3 2 3 | 9 2.6| Myelofibrosis | | 1 3.0| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + | 27 | Mediastinal, Pigmentation | 1 1 1 1 2 1 1 2 1 1 1 1 1 2 1 | 26 1.2| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 | Ectasia | 1 | 1 1.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 3 | 1 3.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 3 | 3 3.3| Pigmentation | 1 1 1 1 1 2 2 2 2 2 2 1 1 1 | 25 1.6| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + M + + + + +| 46 | Atrophy | 3 4 4 4 3 3 3 3 3 3 3 3 3 3 4 3 2 3 4 4 4 3 3 3| 46 3.4| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dilatation | 2 2 | 2 2.0| Galactocele | | 1 2.0| Hyperplasia | 2 1 1 1 1 1 | 14 1.2| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteopetrosis | 4 | 2 4.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 2 1.0| __________________________________________________________________________|____________| Peripheral Nerve | | 1 | __________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6| 7| | DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 6| 0| 3| 3| 1| 3| | | 0| 5| 0| 1| 0| 0| 0| 1| 5| 0| 1| 2| 1| 2| 1| 2| 4| 0| 1| 0| 1| 1| 0| 3| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Inflammation | 1 1 1 1 1 1 1 1 1 1 1 | 23 1.0| Pigmentation | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 40 1.0| Alveolar Epithelium, Hyperplasia | 1 1 2 1 1 1 1 1 | 8 1.1| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Foreign Body | X | 2 | Inflammation | 2 | 3 1.3| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + | 3 | Cataract | 3 | 1 3.0| Hemorrhage | | 1 3.0| Retina, Degeneration | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hydronephrosis | | 1 2.0| Inflammation | | 1 2.0| Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 39 1.0| Pigmentation | 1 1 1 2 | 5 1.2| Pelvis, Inflammation | 1 | 2 1.5| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Calculus Micro Observation Only | | 1 | Transitional Epithelium, Hyperplasia | | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 4| 6| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 8| 3| 6| 3| 3| 3| 9| 5| 3| 3| | 2| 1| 0| 2| 0| 1| 1| 0| 2| 0| 9| 2| 2| 1| 2| 0| 0| 6| 1| 2| 2| 0| 1| 3| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X| Clear Cell Focus | | Eosinophilic Focus | X X X X X | Hematopoietic Cell Proliferation | | Hepatodiaphragmatic Nodule | X X X | Inflammation | 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1| Mixed Cell Focus | X X X X X X X X X| Vacuolization Cytoplasmic | 1 1 2 1| Bile Duct, Hyperplasia | 2 1 1 1 1 1 1 1 | Centrilobular, Degeneration | 2 2 2 3 | Centrilobular, Hypertrophy | 2 | __________________________________________________________________________| Mesentery | + + + + | Inflammation | 3 | Artery, Inflammation | 3 | Fat, Necrosis | 3 3 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 3 1 1 1 | Hyperplasia | | Inflammation | 1 1| Thrombosis | 4 | Artery, Inflammation | 3 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 | Cytoplasmic Alteration | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | 1 | Inflammation | | Ulcer | 2 | __________________________________________________________________________| Tongue | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 4| 6| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 8| 3| 6| 3| 3| 3| 9| 5| 3| 3| | 2| 1| 0| 2| 0| 1| 1| 0| 2| 0| 9| 2| 2| 1| 2| 0| 0| 6| 1| 2| 2| 0| 1| 3| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 2 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 | Inflammation | 1 1 | Thrombosis | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 2 2 1 1 1 1 1 1 2 | Degeneration, Cystic | 2 | Hyperplasia | 1 1 1 1 1 | Hypertrophy | 2 1 | Vacuolization Cytoplasmic | 1 3 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + M +| Hyperplasia | 1 1 1 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + M + + + + + + M + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + I + + + + + + + + + +| Angiectasis | 2 2 1 1 2 2 2 2 4| Cyst | 2 2 1 2 | Pars Distalis, Hyperplasia | 2 2 1 3 1 2 1 3 1 2 2 4 2 3 2 4| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | C-Cell, Hyperplasia | 1 1 2 1 2 1 1 1 1 1 1 1 1 1 1 1 3 2 1 1| Follicular Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 3 | Inflammation | 1 2 1 1 1 1 1| Duct, Cyst | 4 3 2 2 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | Cyst | 3 3 2 4| Infiltration Cellular, Histiocyte | 4 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 2 | Endometrium, Hyperplasia, Cystic | 1 2 1 3| __________________________________________________________________________| Vagina | + | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 4| 6| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 8| 3| 6| 3| 3| 3| 9| 5| 3| 3| | 2| 1| 0| 2| 0| 1| 1| 0| 2| 0| 9| 2| 2| 1| 2| 0| 0| 6| 1| 2| 2| 0| 1| 3| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Hyperplasia | | Inflammation | 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Hyperplasia | 3 1 2 2 2 3 | __________________________________________________________________________| Lymph Node | + + + + + + + + + + +| Mediastinal, Hyperplasia, Plasma Cell| 3 | Mediastinal, Pigmentation | 1 2 1 2 2 2 2 1| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 1 1 1 1 | Hyperplasia, Plasma Cell | 3 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Hyperplasia, Plasma Cell | 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 3 | Pigmentation | 1 1 2 2 1 2 1 2 1| Capsule, Fibrosis | 1 | Lymphoid Follicle, Atrophy | | __________________________________________________________________________| Thymus | + M + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 4 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 3 3| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 2 1 1 1 1 1 3 4| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Inflammation | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteopetrosis | 2 | __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | Inflammation | 1 2 1 1 1 1 1 1 1 1 1 | Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Thrombosis | 4 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 4| 6| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 8| 3| 6| 3| 3| 3| 9| 5| 3| 3| | 2| 1| 0| 2| 0| 1| 1| 0| 2| 0| 9| 2| 2| 1| 2| 0| 0| 6| 1| 2| 2| 0| 1| 3| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Alveolar Epithelium, Hyperplasia | 2 | Bronchiole, Hyperplasia | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | Cataract | 3 2 | Retina, Degeneration | 4 3 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Glomerulosclerosis | | Inflammation | 1 | Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Pigmentation | 1 1 | Vacuolization Cytoplasmic | | Pelvis, Inflammation | 1 | Renal Tubule, Hyperplasia | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Serosa, Fibrosis | 2 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 __________________________________________________________________________________________________________________________________ | 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| | DAY ON TEST | 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 5| 6| 3| 3| 1| 3| 3| | | 3| 9| 1| 1| 1| 1| 2| 2| 1| 0| 0| 1| 2| 2| 0| 2| 0| 1| 2| 6| 0| 1| 6| 2| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 30 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X | 4 | __________________________________________________________________________|____________| Intestine Large, Cecum | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation | 3 | 1 3.0| __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 1 | 1 1.0| Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X X X| 48 | Clear Cell Focus | X X X X X | 5 | Eosinophilic Focus | X X X X X| 10 | Hematopoietic Cell Proliferation | 1 | 1 1.0| Hepatodiaphragmatic Nodule | X X X X X X X X| 11 | Inflammation | 1 1 1 1 1 2 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 2| 44 1.1| Mixed Cell Focus | X X X X X X X X X X| 19 | Vacuolization Cytoplasmic | 1 1 1 1 2 1 1| 11 1.2| Bile Duct, Hyperplasia | 1 1 1 1 | 12 1.1| Centrilobular, Degeneration | 1 | 5 2.0| Centrilobular, Hypertrophy | 1 | 2 1.5| __________________________________________________________________________|____________| Mesentery | + + + + | 8 | Inflammation | 2 | 2 2.5| Artery, Inflammation | | 1 3.0| Fat, Necrosis | 3 2 3 | 6 2.7| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 1 1 1 | 8 1.3| Hyperplasia | 1 | 1 1.0| Inflammation | | 2 1.0| Thrombosis | | 1 4.0| Artery, Inflammation | | 1 3.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 1.0| Cytoplasmic Alteration | 1 | 1 1.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 __________________________________________________________________________________________________________________________________ | 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| | DAY ON TEST | 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 5| 6| 3| 3| 1| 3| 3| | | 3| 9| 1| 1| 1| 1| 2| 2| 1| 0| 0| 1| 2| 2| 0| 2| 0| 1| 2| 6| 0| 1| 6| 2| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 30 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Erosion | | 1 1.0| Inflammation | 2 | 1 2.0| Ulcer | | 1 2.0| __________________________________________________________________________|____________| Tongue | + | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation | | 1 2.0| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 1 1 1 1 1 1 2 2 1 2 1 | 23 1.1| Inflammation | 1 1 | 4 1.0| Thrombosis | | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 1 2 1 1 1 1 1 1 2 1| 21 1.3| Degeneration, Cystic | | 1 2.0| Hyperplasia | 1 1 1 1 1 1 | 11 1.0| Hypertrophy | 1 1 | 4 1.3| Vacuolization Cytoplasmic | 1 3 2 1 | 6 1.8| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 1 2 1 1 | 8 1.1| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Angiectasis | 1 2 1 2 3 2 2 1 | 17 1.9| Cyst | | 4 1.8| Pars Distalis, Hyperplasia | 1 4 1 3 1 1 3 1 2 3 1 1 | 28 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 1 | 1 1.0| C-Cell, Hyperplasia | 1 4 2 1 2 2 1 1 2 1 3 1 1 1 1 1 1 1| 38 1.4| Follicular Cell, Hyperplasia | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 4 1| 6 2.3| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 __________________________________________________________________________________________________________________________________ | 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| | DAY ON TEST | 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 5| 6| 3| 3| 1| 3| 3| | | 3| 9| 1| 1| 1| 1| 2| 2| 1| 0| 0| 1| 2| 2| 0| 2| 0| 1| 2| 6| 0| 1| 6| 2| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 30 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Inflammation | 1 1 2 2 1 1 4 1 1 1 | 17 1.4| Duct, Cyst | 2 | 5 2.6| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 3 | 2 2.5| Cyst | 1 3 4 | 7 2.9| Infiltration Cellular, Histiocyte | 1 | 2 2.5| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation | | 1 2.0| Endometrium, Hyperplasia, Cystic | 2 1 2 | 7 1.7| __________________________________________________________________________|____________| Vagina | + | 2 | Hyperplasia | 4 | 1 4.0| Inflammation | 3 | 2 2.5| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 3 | 1 3.0| Hyperplasia | 3 3 3 3 3 3 | 12 2.6| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + +| 23 | Mediastinal, Hyperplasia, Plasma Cell| | 1 3.0| Mediastinal, Pigmentation | 1 1 1 2 2 2 1 1 2 1 2| 19 1.5| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 1 1 1 1 | 8 1.0| Hyperplasia, Plasma Cell | 2 3 | 4 2.8| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 3 | 1 3.0| Hyperplasia, Plasma Cell | | 1 3.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 4 2 | 4 2.8| Pigmentation | 1 2 2 2 1 1 2 2 1 1 2 1 1 1 1 1 2| 26 1.4| Capsule, Fibrosis | | 1 1.0| Lymphoid Follicle, Atrophy | 2 | 1 2.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 | Atrophy | 2 2 3 3 3 3 4 3 3 3 3 2 2 3 2 2 3 4 4 3 3 3 3 3| 46 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 1 1 1 1 1 2 1 1| 19 1.4| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Inflammation | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 __________________________________________________________________________________________________________________________________ | 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| | DAY ON TEST | 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 5| 6| 3| 3| 1| 3| 3| | | 3| 9| 1| 1| 1| 1| 2| 2| 1| 0| 0| 1| 2| 2| 0| 2| 0| 1| 2| 6| 0| 1| 6| 2| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 30 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteopetrosis | 3 | 2 2.5| __________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 1 2.0| Inflammation | 1 1 1 1 1 1 1 1 1 1| 21 1.0| Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 40 1.0| Thrombosis | | 1 4.0| Alveolar Epithelium, Hyperplasia | 2 2 2 1 1 1 | 7 1.6| Bronchiole, Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation | 3 | 2 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 2 | Cataract | | 2 2.5| Retina, Degeneration | | 2 3.5| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Glomerulosclerosis | 1 | 1 1.0| Inflammation | | 1 1.0| Nephropathy | 1 2 2 1 1 1 1 1 1 1 1 1 1 1 2 1 2 2 1 1 1| 43 1.1| Pigmentation | | 2 1.0| Vacuolization Cytoplasmic | 2 | 1 2.0| Pelvis, Inflammation | | 1 1.0| Renal Tubule, Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Serosa, Fibrosis | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 _____________________________________________________________________________________________________________________ | 5| 5| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| DAY ON TEST | 2| 3| 6| 3| 3| 6| 3| 3| 3| 3| 3| 2| 3| 7| 3| 3| 3| 0| 0| 3| 3| 3| 3| 2| 7| | 6| 6| 8| 0| 1| 2| 0| 0| 2| 2| 0| 5| 1| 6| 2| 0| 1| 1| 3| 1| 1| 0| 1| 3| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 100 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X | Clear Cell Focus | X | Eosinophilic Focus | X X X X X X X | Hepatodiaphragmatic Nodule | X X X X X X X X| Inflammation | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 | Mixed Cell Focus | X | Necrosis | 2 | Pigmentation | | Vacuolization Cytoplasmic | 2 1 4| Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 | Centrilobular, Degeneration | 2 3 4 3 2| Centrilobular, Hypertrophy | 1 1 1 1 1 1 2 2 1 1 2 1 | __________________________________________________________________________| Mesentery | + | Fat, Necrosis | 3 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 2 1 1 1 | Cytoplasmic Alteration | | Inflammation | 1 1 1 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 1 | Cytoplasmic Alteration | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | | Hyperplasia | 3 | Inflammation | | Ulcer | 1 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | | Ulcer | 1 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 _____________________________________________________________________________________________________________________ | 5| 5| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| DAY ON TEST | 2| 3| 6| 3| 3| 6| 3| 3| 3| 3| 3| 2| 3| 7| 3| 3| 3| 0| 0| 3| 3| 3| 3| 2| 7| | 6| 6| 8| 0| 1| 2| 0| 0| 2| 2| 0| 5| 1| 6| 2| 0| 1| 1| 3| 1| 1| 0| 1| 3| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 100 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1| Thrombosis | 1 | Valve, Inflammation | 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 | Degeneration, Cystic | 1 | Hyperplasia | 1 1 1 1 1 1 1 2 1 1 | Hypertrophy | 1| Inflammation | | Necrosis | | Vacuolization Cytoplasmic | 1 1 3 1 3| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 4 | Hyperplasia | 1| __________________________________________________________________________| Islets, Pancreatic | + + + + M + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | M M + + M + M + + + + + + + + + + + + M + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 1 3 2 1 2 2 2 1 1 2 1 2 | Pars Distalis, Hyperplasia | 3 1 3 1 3 4 1 1 1 1 1 4 1| Pars Intermedia, Hyperplasia | | Pars Nervosa, Hyperplasia | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 4 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 | Inflammation | 1 1 1 1 1 1 1 1 2 1 | Duct, Cyst | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Cyst | 1 1| Infiltration Cellular, Histiocyte | 2 2 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 4 | Hydrometra | 3 4 | Cervix, Cyst, Squamous | 3 | Cervix, Hydrometra | | Cervix, Hyperplasia, Squamous | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 _____________________________________________________________________________________________________________________ | 5| 5| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| DAY ON TEST | 2| 3| 6| 3| 3| 6| 3| 3| 3| 3| 3| 2| 3| 7| 3| 3| 3| 0| 0| 3| 3| 3| 3| 2| 7| | 6| 6| 8| 0| 1| 2| 0| 0| 2| 2| 0| 5| 1| 6| 2| 0| 1| 1| 3| 1| 1| 0| 1| 3| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 100 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Cervix, Inflammation | 3 | Endometrium, Hyperplasia, Cystic | 1 2 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 3 2 | Inflammation, Granulomatous | 2 | __________________________________________________________________________| Lymph Node | + + + + + + + + + + | Mediastinal, Pigmentation | 1 1 1 1 2 1 2 1 1 | __________________________________________________________________________| Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 1 1 1 | Hyperplasia, Plasma Cell | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Spleen | | Fibrosis | | Hematopoietic Cell Proliferation | 1 3 1 | Infarct | | Pigmentation | 2 1 1 1 1 1 1 1 1 1 2 1 1 1 | Lymphoid Follicle, Atrophy | 2 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 4 3 3 2 4 3 3 3 3 3 4 3 4 4 4 4 4 3 3 4 3 4 4| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Galactocele | 4 4 2 2| Hyperplasia | 1 1 1 2 1 1 1 1| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteopetrosis | 3 4 3 2 2 | __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 1 | __________________________________________________________________________| Peripheral Nerve | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 _____________________________________________________________________________________________________________________ | 5| 5| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| DAY ON TEST | 2| 3| 6| 3| 3| 6| 3| 3| 3| 3| 3| 2| 3| 7| 3| 3| 3| 0| 0| 3| 3| 3| 3| 2| 7| | 6| 6| 8| 0| 1| 2| 0| 0| 2| 2| 0| 5| 1| 6| 2| 0| 1| 1| 3| 1| 1| 0| 1| 3| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 100 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Inflammation | 1 1 1 1 1 1 1 1 1 1 1 | Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Thrombosis | 1 | Alveolar Epithelium, Hyperplasia | 2 1 1 4 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | X | Inflammation | 1 2 2 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infarct | 2 | Inflammation | 2 | Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1| Pigmentation | 1 1 1 1| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 8| 3| 3| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 6| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 2| 7| 2| 1| 0| 4| 1| 0| 5| 2| 0| 0| 1| 1| 7| 8| 1| 0| 2| 1| 0| 2| 0| 0| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 100 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | | 2 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X X | 3 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 1 | 1 1.0| Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X| 43 | Clear Cell Focus | | 1 | Eosinophilic Focus | X X X X X X X| 14 | Hepatodiaphragmatic Nodule | X X X X | 12 | Inflammation | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1| 39 1.1| Mixed Cell Focus | X X X X X X | 7 | Necrosis | | 1 2.0| Pigmentation | 1 | 1 1.0| Vacuolization Cytoplasmic | 1 1 3 1 2 1 | 9 1.8| Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1| 21 1.0| Centrilobular, Degeneration | 1 1 3 2 1 | 10 2.2| Centrilobular, Hypertrophy | 2 1 2 1 1 1 1 1 2 2 1 1 | 24 1.3| __________________________________________________________________________|____________| Mesentery | + + + | 4 | Fat, Necrosis | 3 3 3 | 4 3.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 1 1 1 | 8 1.1| Cytoplasmic Alteration | 1 | 1 1.0| Inflammation | 1 1 1 1 | 7 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 2 1.0| Cytoplasmic Alteration | 1 | 1 1.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | 3 | 1 3.0| Hyperplasia | | 1 3.0| Inflammation | 2 | 1 2.0| Ulcer | 2 | 2 1.5| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 8| 3| 3| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 6| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 2| 7| 2| 1| 0| 4| 1| 0| 5| 2| 0| 0| 1| 1| 7| 8| 1| 0| 2| 1| 0| 2| 0| 0| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 100 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Ulcer | 1 | 3 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1| 23 1.0| Thrombosis | | 1 1.0| Valve, Inflammation | | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 1 1 1 1 1 1 1 1 1 1 1 1| 26 1.0| Degeneration, Cystic | 1 | 2 1.0| Hyperplasia | 1 1 1 1 1 1 1 1 1| 19 1.1| Hypertrophy | 1 1 1 1 | 5 1.0| Inflammation | 1 | 1 1.0| Necrosis | 2 | 1 2.0| Vacuolization Cytoplasmic | | 5 1.8| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 4 | 2 4.0| Hyperplasia | 4 4 | 3 3.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + M + + M + + + + M +| 42 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 3 2 1 2 1 2 3 2 2 | 23 1.8| Pars Distalis, Hyperplasia | 3 2 1 4 1 2 2 2 2 3| 23 2.0| Pars Intermedia, Hyperplasia | 1 | 1 1.0| Pars Nervosa, Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1| 34 1.2| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 3 3 4 1 4 | 6 3.0| Inflammation | 3 2 1 2 1 1 1 1 1 3 1| 21 1.3| Duct, Cyst | 1 4 | 2 2.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 8| 3| 3| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 6| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 2| 7| 2| 1| 0| 4| 1| 0| 5| 2| 0| 0| 1| 1| 7| 8| 1| 0| 2| 1| 0| 2| 0| 0| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 100 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 3 | 1 3.0| Cyst | 2 | 3 1.3| Infiltration Cellular, Histiocyte | 2 | 3 2.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 1 4.0| Hydrometra | 3 4 | 4 3.5| Cervix, Cyst, Squamous | | 1 3.0| Cervix, Hydrometra | 3 | 1 3.0| Cervix, Hyperplasia, Squamous | 2 | 1 2.0| Cervix, Inflammation | | 1 3.0| Endometrium, Hyperplasia, Cystic | 2 2 1 2 | 7 1.7| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 3 3 4 2 1 | 8 2.6| Inflammation, Granulomatous | 1 | 2 1.5| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + +| 28 | Mediastinal, Pigmentation | 1 1 1 2 1 1 1 2 2 1 1 1 1 1 1 1 1| 26 1.2| __________________________________________________________________________|____________| Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +| 48 | Ectasia | 2 1 | 5 1.2| Hyperplasia, Plasma Cell | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 3 | 1 3.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Spleen | X | 1 | Fibrosis | 1 1 | 2 1.0| Hematopoietic Cell Proliferation | 1 1 1 1 | 7 1.3| Infarct | 4 | 1 4.0| Pigmentation | 1 1 2 1 1 1 2 1 2 1 1 1 1 1| 28 1.2| Lymphoid Follicle, Atrophy | | 1 2.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 3 4 4 2 3 3 4 4 3 2 4 3 3 3 3 3 3 4 3 3 3 3 3| 47 3.3| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 1 | 1 1.0| Galactocele | 3 2 | 6 2.8| Hyperplasia | 1 1 1 1 1 1 1 1 1 2 1 1 | 20 1.1| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 8| 3| 3| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 6| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 2| 7| 2| 1| 0| 4| 1| 0| 5| 2| 0| 0| 1| 1| 7| 8| 1| 0| 2| 1| 0| 2| 0| 0| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 100 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteopetrosis | 3 | 6 2.8| __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 1 1.0| __________________________________________________________________________|____________| Peripheral Nerve | + | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 1 | 1 1.0| Inflammation | 1 1 1 1 2 1 1 1 1 1 1 1| 23 1.0| Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 42 1.0| Thrombosis | | 1 1.0| Alveolar Epithelium, Hyperplasia | 1 2 1 4 1| 9 1.9| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Foreign Body | | 1 | Inflammation | | 4 1.5| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infarct | | 1 2.0| Inflammation | | 1 2.0| Nephropathy | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 42 1.0| Pigmentation | 1 1 1 1 1 | 9 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 _____________________________________________________________________________________________________________________ | 7| 7| 7| 4| 5| 6| 7| 4| 7| 7| 7| 7| 3| 7| 7| 7| 5| 7| 5| 7| 7| 6| 7| 7| 7| DAY ON TEST | 3| 3| 3| 6| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 3| 1| 3| 8| 3| 3| 5| 3| 3| 3| | 0| 0| 0| 5| 1| 1| 1| 4| 2| 2| 2| 0| 7| 1| 2| 0| 1| 2| 4| 0| 1| 9| 0| 1| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 300 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + M + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 | Basophilic Focus | X X X X X X X X X X X X X X X X X| Clear Cell Focus | X | Eosinophilic Focus | X X| Hematopoietic Cell Proliferation | 1 | Hepatodiaphragmatic Nodule | X X X X X X X| Inflammation | 1 1 1 1 1 1 1 1 2 1 1 1 1 2 1| Mixed Cell Focus | X X X| Necrosis | 1 1 | Vacuolization Cytoplasmic | 1 1 2 2 1 1 1 | Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Centrilobular, Degeneration | 2 2 1 | Centrilobular, Hypertrophy | 2 2 2 2 1 1 1 2 1 1 2 2 2 1 2 1 2 2 2 2| __________________________________________________________________________| Mesentery | + + +| Artery, Inflammation | 2 | Fat, Necrosis | 3 3| __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 1 1 | Cytoplasmic Alteration | 1 | Hyperplasia | | Inflammation | 1 | Metaplasia, Hepatocyte | 1 | Artery, Inflammation | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | 1 | Mineralization | | __________________________________________________________________________| Tongue | + | __________________________________________________________________________| Tooth | + + + | Inflammation | 4 | Peridontal Tissue, Inflammation | 2 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 _____________________________________________________________________________________________________________________ | 7| 7| 7| 4| 5| 6| 7| 4| 7| 7| 7| 7| 3| 7| 7| 7| 5| 7| 5| 7| 7| 6| 7| 7| 7| DAY ON TEST | 3| 3| 3| 6| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 3| 1| 3| 8| 3| 3| 5| 3| 3| 3| | 0| 0| 0| 5| 1| 1| 1| 4| 2| 2| 2| 0| 7| 1| 2| 0| 1| 2| 4| 0| 1| 9| 0| 1| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 300 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Aorta, Inflammation | 2 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 2 1 1 1 1 1 1 1 1 1 1 1 2 1 | Inflammation | 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | 2 | Angiectasis | 1 1 1 1 1 1 1 1 1 1 2 1| Hyperplasia | 1 1 1 1 1 1 1 1 1| Hypertrophy | 2 1 | Necrosis | 1 2 | Vacuolization Cytoplasmic | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + M M + + + + + + + M + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 2 1 2 4 2 1 2 1 2| Cyst | 1 | Pars Distalis, Hyperplasia | 3 3 3 1 3 2 3 2 1 2 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 4 2 1 3 1 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + M + + + + + + + + + + +| Hyperplasia | 2 | Inflammation | 1 1 1 1 1 1 1| Duct, Cyst | 3 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Infiltration Cellular, Histiocyte | 1 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 | Dilatation | | Hyperplasia | | Inflammation | 1 | Cervix, Cyst, Squamous | | Cervix, Inflammation | 4 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 _____________________________________________________________________________________________________________________ | 7| 7| 7| 4| 5| 6| 7| 4| 7| 7| 7| 7| 3| 7| 7| 7| 5| 7| 5| 7| 7| 6| 7| 7| 7| DAY ON TEST | 3| 3| 3| 6| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 3| 1| 3| 8| 3| 3| 5| 3| 3| 3| | 0| 0| 0| 5| 1| 1| 1| 4| 2| 2| 2| 0| 7| 1| 2| 0| 1| 2| 4| 0| 1| 9| 0| 1| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 300 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Endometrium, Adenomyosis | 2 | Endometrium, Hyperplasia, Cystic | 1 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 3 2 3 3 3 | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + +| Mediastinal, Congestion | | Mediastinal, Ectasia | | Mediastinal, Pigmentation | 1 1 2 1 2 1 1 1 2 1 2| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 1 1 | Hyperplasia, Plasma Cell | 4 4 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 1 | Hematopoietic Cell Proliferation | 4 1 | Pigmentation | 1 2 2 1 2 2 1 1 1 1 3 2 2 1 2 2 1| Lymphoid Follicle, Atrophy | 3 3 3 | __________________________________________________________________________| Thymus | + + + + M + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 4 3 3 3 3 4 4 3 3 3 2 3 4 4 4 3 3 3 3 3 3 2 4| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Galactocele | | Hyperplasia | 1 1 1 1 1| __________________________________________________________________________| Skin | + + + + + + + + + + + + + M + + + + + + + + + + +| Inflammation | 3 | Ulcer | 2 1 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteopetrosis | 3 4 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 2 | Necrosis | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | | Hemorrhage | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 _____________________________________________________________________________________________________________________ | 7| 7| 7| 4| 5| 6| 7| 4| 7| 7| 7| 7| 3| 7| 7| 7| 5| 7| 5| 7| 7| 6| 7| 7| 7| DAY ON TEST | 3| 3| 3| 6| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 3| 1| 3| 8| 3| 3| 5| 3| 3| 3| | 0| 0| 0| 5| 1| 1| 1| 4| 2| 2| 2| 0| 7| 1| 2| 0| 1| 2| 4| 0| 1| 9| 0| 1| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 300 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Inflammation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Necrosis | | Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Thrombosis | | Alveolar Epithelium, Hyperplasia | 1 2 1 | Mediastinum, Thrombosis | | Serosa, Inflammation | 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | | Nasolacrimal Duct, Inflammation | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Atrophy | | Cataract | 3 | Hemorrhage | | Cornea, Edema | | Retina, Degeneration | 2 | __________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydronephrosis | | Inflammation | 1 | Nephropathy | 1 2 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Pigmentation | 1 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Calculus Gross Observation | X | Transitional Epithelium, Hyperplasia | 4 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 3| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 0| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| | | 3| 2| 1| 9| 0| 7| 2| 2| 0| 4| 1| 1| 1| 2| 1| 2| 9| 1| 0| 1| 1| 2| 1| 7| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 300 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X | 4 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 1 | 2 1.0| Basophilic Focus | X X X X X X X X X X X X X X X X X X X| 36 | Clear Cell Focus | X | 2 | Eosinophilic Focus | X X X X X | 7 | Hematopoietic Cell Proliferation | | 1 1.0| Hepatodiaphragmatic Nodule | X X X X X X X | 14 | Inflammation | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1| 30 1.1| Mixed Cell Focus | X X X X X X | 9 | Necrosis | 1 2 | 4 1.3| Vacuolization Cytoplasmic | 1 1 | 9 1.2| Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 32 1.0| Centrilobular, Degeneration | 3 1 1 2 | 7 1.7| Centrilobular, Hypertrophy | 1 1 1 2 2 2 2 2 2 2 2 2 2 1 2 2 1 2| 38 1.7| __________________________________________________________________________|____________| Mesentery | + | 4 | Artery, Inflammation | | 1 2.0| Fat, Necrosis | 3 | 3 3.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 1 1 1 1 1 | 8 1.0| Cytoplasmic Alteration | | 1 1.0| Hyperplasia | 3 | 1 3.0| Inflammation | 1 1 | 3 1.0| Metaplasia, Hepatocyte | | 1 1.0| Artery, Inflammation | 1 | 1 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Erosion | 1 1 | 3 1.0| Mineralization | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 3| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 0| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| | | 3| 2| 1| 9| 0| 7| 2| 2| 0| 4| 1| 1| 1| 2| 1| 2| 9| 1| 0| 1| 1| 2| 1| 7| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 300 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Tongue | | 1 | __________________________________________________________________________|____________| Tooth | + | 4 | Inflammation | | 1 4.0| Peridontal Tissue, Inflammation | 2 | 3 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Aorta, Inflammation | | 1 2.0| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 | 27 1.1| Inflammation | | 1 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | | 1 2.0| Angiectasis | 1 1 1 1 1 1 1 1 1 1 2 1 1 1| 26 1.1| Hyperplasia | 1 1 1 1 1 1 1 1 2| 18 1.1| Hypertrophy | 1 | 3 1.3| Necrosis | | 2 1.5| Vacuolization Cytoplasmic | 1| 1 1.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + M + + + + + + + M M + + + + + + M + +| 43 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 1 1 3 2 3 2 2 2 2 2 | 21 1.9| Cyst | 3 2 | 3 2.0| Pars Distalis, Hyperplasia | 2 2 2 1 4 1 3 2 3 3 2 1 2| 24 2.2| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 1 4 1 1 1 1 1 2 1 1 1 1 1 1 1 1| 23 1.4| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 | Hyperplasia | 3 3 | 3 2.7| Inflammation | 1 1 1 1 1 1 1 1 1 1 1 | 18 1.0| Duct, Cyst | 2 1| 3 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 3| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 0| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| | | 3| 2| 1| 9| 0| 7| 2| 2| 0| 4| 1| 1| 1| 2| 1| 2| 9| 1| 0| 1| 1| 2| 1| 7| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 300 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 4 1 | 2 2.5| Infiltration Cellular, Histiocyte | | 1 1.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 4.0| Dilatation | 4 | 1 4.0| Hyperplasia | 2 | 1 2.0| Inflammation | | 1 1.0| Cervix, Cyst, Squamous | 2 | 1 2.0| Cervix, Inflammation | 4 | 2 4.0| Endometrium, Adenomyosis | | 1 2.0| Endometrium, Hyperplasia, Cystic | 1 2 2 1 | 6 1.5| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 3 2 3 | 12 2.5| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + +| 28 | Mediastinal, Congestion | 4 | 1 4.0| Mediastinal, Ectasia | 2 | 1 2.0| Mediastinal, Pigmentation | 1 1 1 2 2 2 1 1 1 2 1 1 2| 24 1.4| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 1 1 1 | 5 1.0| Hyperplasia, Plasma Cell | 3 3 4 | 5 3.6| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | | 1 1.0| Hematopoietic Cell Proliferation | | 2 2.5| Pigmentation | 1 1 2 1 2 2 1 1 1 2 2 1 2 2 1| 32 1.5| Lymphoid Follicle, Atrophy | | 3 3.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 | Atrophy | 3 3 2 4 4 4 4 4 3 4 3 3 3 3 4 4 3 3 4 4 4 3 4 3| 48 3.4| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 2 | 1 2.0| Galactocele | 4 | 1 4.0| Hyperplasia | 1 1 1 3 1 | 10 1.2| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 3| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 0| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| | | 3| 2| 1| 9| 0| 7| 2| 2| 0| 4| 1| 1| 1| 2| 1| 2| 9| 1| 0| 1| 1| 2| 1| 7| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 300 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | Ulcer | | 2 1.5| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteopetrosis | 3 3 | 4 3.3| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation | | 1 2.0| Necrosis | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | 2 | 1 2.0| Hemorrhage | 1 | 1 1.0| Inflammation | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 2 1| 31 1.1| Necrosis | 2 2 | 2 2.0| Pigmentation | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 35 1.0| Thrombosis | 3 | 1 3.0| Alveolar Epithelium, Hyperplasia | 3 1 1 3 3 1 | 9 1.8| Mediastinum, Thrombosis | 4 | 1 4.0| Serosa, Inflammation | | 1 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation | 1 1 2 1 | 4 1.3| Nasolacrimal Duct, Inflammation | 3 | 1 3.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation | | 1 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + + | 4 | Atrophy | 3 | 1 3.0| Cataract | 3 3 | 3 3.0| Hemorrhage | 2 | 1 2.0| Cornea, Edema | 3 | 1 3.0| Retina, Degeneration | 3 4 | 3 3.0| __________________________________________________________________________|____________| Zymbal's Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 3| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 0| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| | | 3| 2| 1| 9| 0| 7| 2| 2| 0| 4| 1| 1| 1| 2| 1| 2| 9| 1| 0| 1| 1| 2| 1| 7| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 300 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Hydronephrosis | 2 | 1 2.0| Inflammation | 1 | 2 1.0| Nephropathy | 1 1 2 2 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 42 1.2| Pigmentation | 1 2 1 1 1 2 1 | 9 1.2| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Calculus Gross Observation | | 1 | Transitional Epithelium, Hyperplasia | | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 _____________________________________________________________________________________________________________________ | 6| 3| 7| 6| 6| 3| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 6| 3| DAY ON TEST | 8| 6| 3| 3| 8| 1| 2| 2| 2| 3| 3| 1| 4| 3| 2| 3| 9| 1| 1| 2| 3| 4| 1| 4| 6| | 2| 8| 0| 3| 2| 2| 9| 9| 9| 0| 0| 7| 0| 0| 9| 0| 7| 2| 8| 9| 0| 2| 8| 8| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X X X X X X X X X X X | Clear Cell Focus | X X X | Degeneration, Cystic | 1 1 1 1 | Eosinophilic Focus | X X | Hematopoietic Cell Proliferation | | Hepatodiaphragmatic Nodule | X X | Inflammation | 1 1 1 1 1 1 1 1 1 | Mixed Cell Focus | X X X X | Necrosis | 2 1 | Pigmentation | 2 | Vacuolization Cytoplasmic | 1 1 1 1 1 | Bile Duct, Hyperplasia | 2 1 2 3 3 1 1 1 1 1 1 3 1 2 2 1 2 2 2 2 1 1 2 | Centrilobular, Degeneration | 2 3 1 1 1 2 3 2 1 | Centrilobular, Necrosis | | __________________________________________________________________________| Mesentery | + + + | Necrosis | 2 | Fat, Inflammation | | Fat, Necrosis | 3 3 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 1 1 1 1 1 1 | Cytoplasmic Alteration | 1 | Hyperplasia | 1 1 | Inflammation | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 | Cytoplasmic Alteration | | Duct, Hyperplasia | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 2 | Hyperplasia | 3 3 | Inflammation | 3 | Ulcer | 3 4 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 _____________________________________________________________________________________________________________________ | 6| 3| 7| 6| 6| 3| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 6| 3| DAY ON TEST | 8| 6| 3| 3| 8| 1| 2| 2| 2| 3| 3| 1| 4| 3| 2| 3| 9| 1| 1| 2| 3| 4| 1| 4| 6| | 2| 8| 0| 3| 2| 2| 9| 9| 9| 0| 0| 7| 0| 0| 9| 0| 7| 2| 8| 9| 0| 2| 8| 8| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Erosion | 1 | Hyperplasia | 2 | Ulcer | 1 | __________________________________________________________________________| Tooth | | Peridontal Tissue, Inflammation | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 2 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 2 1 1 2 1 1 1 1 1 2 1 1 2 1 1 1 | Inflammation | 1 | Thrombosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 1 | Degeneration, Cystic | 1| Hyperplasia | 1 1 1 2 1 2 1| Hypertrophy | 1 3 | Necrosis | | Vacuolization Cytoplasmic | 2 2 2 3 4 3| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 2 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + M + + + + M + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 4 4 3 | Cyst | 1 | Hemorrhage | | Pars Distalis, Hyperplasia | 3 3 1 1 2 3 | Pars Distalis, Pseudocyst | 2 2 2 | Pars Intermedia, Cyst | | Pars Intermedia, Pseudocyst | 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | | C-Cell, Hyperplasia | 2 1 1 1 1 1 1 2 1 1 3 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 _____________________________________________________________________________________________________________________ | 6| 3| 7| 6| 6| 3| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 6| 3| DAY ON TEST | 8| 6| 3| 3| 8| 1| 2| 2| 2| 3| 3| 1| 4| 3| 2| 3| 9| 1| 1| 2| 3| 4| 1| 4| 6| | 2| 8| 0| 3| 2| 2| 9| 9| 9| 0| 0| 7| 0| 0| 9| 0| 7| 2| 8| 9| 0| 2| 8| 8| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Hyperplasia | | Inflammation | 1 | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 2 1 1 2 1 1 2 1 2 2 2 1 2 2 2 2 2 3 2 1| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 3 1 3 1 1 3 1 3 3 2 1 1 1 2| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | Inflammation | 1| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 4 3| Hyperplasia | | Artery, Inflammation | 2 | Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 2 3 2 2 4 4 3 2| Myelofibrosis | 4 | Necrosis | | __________________________________________________________________________| Lymph Node | + + + + + + + | Mediastinal, Necrosis | 4 | Mediastinal, Pigmentation | 1 1 2 | Renal, Hyperplasia, Plasma Cell | | Renal, Necrosis | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | | Hyperplasia, Plasma Cell | 4 4 | Necrosis | 4 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | Necrosis | 4 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Spleen | X | Fibrosis | 4 | Hematopoietic Cell Proliferation | 2 1 | Hyperplasia, Stromal | | Necrosis | | Pigmentation | 2| Lymphoid Follicle, Atrophy | | __________________________________________________________________________| Thymus | + + + + + + + + M + + + + + + + + + + + + + + + +| Atrophy | 4 2 4 4 4 2 4 4 4 2 4 4 3 3 4 2 3 3 4 3 4 4| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 _____________________________________________________________________________________________________________________ | 6| 3| 7| 6| 6| 3| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 6| 3| DAY ON TEST | 8| 6| 3| 3| 8| 1| 2| 2| 2| 3| 3| 1| 4| 3| 2| 3| 9| 1| 1| 2| 3| 4| 1| 4| 6| | 2| 8| 0| 3| 2| 2| 9| 9| 9| 0| 0| 7| 0| 0| 9| 0| 7| 2| 8| 9| 0| 2| 8| 8| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Mammary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| Cyst | 2 | Hyperplasia | 1 2 | Inflammation | 4 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | Ulcer | 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteopetrosis | 3 | __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3 2 | Necrosis | 2 | __________________________________________________________________________| Spinal Cord | + | Hemorrhage | 1 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | X | Hemorrhage | 2 1 | Inflammation, Granulomatous | 2 | Inflammation | 1 1 1 1 1 1 1 1 | Necrosis | | Pigmentation | 1 | Thrombosis | 1 | Alveolar Epithelium, Hyperplasia | 1 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | | Inflammation | 1 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Zymbal's Gland | +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infarct | 4 | Nephropathy | 1 2 1 2 1 2 2 1 1 1 3 2 1 2 1 2 1 2 2 1 1 | Pigmentation | 1 2 1 1 1 1 1 1 1| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 _____________________________________________________________________________________________________________________ | 6| 3| 7| 6| 6| 3| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 6| 3| DAY ON TEST | 8| 6| 3| 3| 8| 1| 2| 2| 2| 3| 3| 1| 4| 3| 2| 3| 9| 1| 1| 2| 3| 4| 1| 4| 6| | 2| 8| 0| 3| 2| 2| 9| 9| 9| 0| 0| 7| 0| 0| 9| 0| 7| 2| 8| 9| 0| 2| 8| 8| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Artery, Inflammation | 2 | Renal Tubule, Degeneration | 1| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 7| 3| | DAY ON TEST | 8| 2| 2| 2| 1| 3| 2| 2| 5| 2| 3| 3| 6| 3| 4| 3| 1| 8| 2| 2| 2| 7| 1| 3| 1| | | 2| 9| 9| 9| 3| 0| 9| 3| 4| 9| 0| 0| 9| 0| 0| 0| 1| 7| 9| 8| 9| 4| 4| 0| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X | 3 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ulcer | 1 | 1 1.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X X X X X X X X X X X X | 30 | Clear Cell Focus | X X X | 6 | Degeneration, Cystic | 1 | 5 1.0| Eosinophilic Focus | X X X X | 6 | Hematopoietic Cell Proliferation | 1 | 1 1.0| Hepatodiaphragmatic Nodule | X X X X X | 7 | Inflammation | 1 1 1 1 1 1 1 1 1 | 18 1.0| Mixed Cell Focus | X X X | 7 | Necrosis | 1 4 | 4 2.0| Pigmentation | 1 | 2 1.5| Vacuolization Cytoplasmic | 1 1 2 1 | 9 1.1| Bile Duct, Hyperplasia | 3 1 1 2 2 2 2 3 2 2 2 2 2 2 1 2 1 1 1 3 3 1 1| 46 1.7| Centrilobular, Degeneration | 2 2 2 2 3 2 2 3 2 | 18 2.0| Centrilobular, Necrosis | 4 | 1 4.0| __________________________________________________________________________|____________| Mesentery | + + + +| 7 | Necrosis | | 1 2.0| Fat, Inflammation | 3 | 1 3.0| Fat, Necrosis | 1 | 3 2.3| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 1 1 2 1 1 2 1 | 14 1.4| Cytoplasmic Alteration | 1 | 2 1.0| Hyperplasia | 4 | 3 2.0| Inflammation | 1 | 1 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 1.0| Cytoplasmic Alteration | 1 | 1 1.0| Duct, Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 7| 3| | DAY ON TEST | 8| 2| 2| 2| 1| 3| 2| 2| 5| 2| 3| 3| 6| 3| 4| 3| 1| 8| 2| 2| 2| 7| 1| 3| 1| | | 2| 9| 9| 9| 3| 0| 9| 3| 4| 9| 0| 0| 9| 0| 0| 0| 1| 7| 9| 8| 9| 4| 4| 0| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Edema | | 1 2.0| Hyperplasia | | 2 3.0| Inflammation | | 1 3.0| Ulcer | | 2 3.5| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Erosion | 1 | 2 1.0| Hyperplasia | | 1 2.0| Ulcer | 1 | 2 1.0| __________________________________________________________________________|____________| Tooth | + | 1 | Peridontal Tissue, Inflammation | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation | | 1 2.0| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 2 2 2 1 1 1 1 2 1 2 1 1 2 2 2 2 2 1 1 1 1 | 39 1.4| Inflammation | | 1 1.0| Thrombosis | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 2 1.0| Degeneration, Cystic | | 1 1.0| Hyperplasia | 1 1 1 1 | 11 1.2| Hypertrophy | 1 | 3 1.7| Necrosis | 1 1 | 2 1.0| Vacuolization Cytoplasmic | 1 2 | 8 2.4| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 4 4 2 1 2 3 4 1 | 14 2.1| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + M +| 46 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 1 2 1 | 7 2.6| Cyst | 1 | 2 1.0| Hemorrhage | 1 | 1 1.0| Pars Distalis, Hyperplasia | 4 2 1 2 1 1 2 1 3 | 15 2.0| Pars Distalis, Pseudocyst | 2 2 2 | 6 2.0| Pars Intermedia, Cyst | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 7| 3| | DAY ON TEST | 8| 2| 2| 2| 1| 3| 2| 2| 5| 2| 3| 3| 6| 3| 4| 3| 1| 8| 2| 2| 2| 7| 1| 3| 1| | | 2| 9| 9| 9| 3| 0| 9| 3| 4| 9| 0| 0| 9| 0| 0| 0| 1| 7| 9| 8| 9| 4| 4| 0| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Pars Intermedia, Pseudocyst | 1 2| 3 1.7| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation | 2 | 1 2.0| C-Cell, Hyperplasia | 4 1 1 1 1 1 1 1 | 19 1.4| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 | 1 1.0| Inflammation | | 1 1.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation | 2 2 2 1 2 1 2 3 1 1 2 2 1 2 1 2 2 2 1 1 2 2 2 1| 46 1.7| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation | 1 1 1 1 2 1 1 1 2 1 1 2 1 | 27 1.6| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 2.0| Inflammation | | 1 1.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 4 3 | 5 3.6| Hyperplasia | 3 | 1 3.0| Artery, Inflammation | | 1 2.0| Interstitial Cell, Hyperplasia | 1 1 1 1 2 1 1 1 1 2 1 1 1 | 28 1.1| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 4 2 2 2 2 4 2 2 | 18 2.6| Myelofibrosis | 2 2 1 | 4 2.3| Necrosis | 4 | 1 4.0| __________________________________________________________________________|____________| Lymph Node | + + + + + + + +| 15 | Mediastinal, Necrosis | | 1 4.0| Mediastinal, Pigmentation | 2 | 4 1.5| Renal, Hyperplasia, Plasma Cell | 3 | 1 3.0| Renal, Necrosis | 4 | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 2 1 1 | 3 1.3| Hyperplasia, Plasma Cell | 4 3 | 4 3.8| Necrosis | | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 7| 3| | DAY ON TEST | 8| 2| 2| 2| 1| 3| 2| 2| 5| 2| 3| 3| 6| 3| 4| 3| 1| 8| 2| 2| 2| 7| 1| 3| 1| | | 2| 9| 9| 9| 3| 0| 9| 3| 4| 9| 0| 0| 9| 0| 0| 0| 1| 7| 9| 8| 9| 4| 4| 0| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 2.0| Necrosis | | 1 4.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Spleen | | 1 | Fibrosis | 1 | 2 2.5| Hematopoietic Cell Proliferation | 2 2 | 4 1.8| Hyperplasia, Stromal | 4 | 1 4.0| Necrosis | 4 | 1 4.0| Pigmentation | | 1 2.0| Lymphoid Follicle, Atrophy | 4 4 | 2 4.0| __________________________________________________________________________|____________| Thymus | M + + + + + + + + + + + + + + + M + + + + + + + M| 46 | Atrophy | 3 3 3 4 3 4 4 4 3 3 3 4 4 1 3 4 3 4 4 4 4 3 | 44 3.4| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + M + + + + + + + + M + + + + + + +| 47 | Cyst | | 1 2.0| Hyperplasia | | 2 1.5| Inflammation | | 1 4.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 2.0| Ulcer | | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteopetrosis | | 1 3.0| __________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 2 2.5| Necrosis | | 1 2.0| __________________________________________________________________________|____________| Spinal Cord | | 1 | Hemorrhage | | 1 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Foreign Body | | 1 | Hemorrhage | | 2 1.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 7| 3| | DAY ON TEST | 8| 2| 2| 2| 1| 3| 2| 2| 5| 2| 3| 3| 6| 3| 4| 3| 1| 8| 2| 2| 2| 7| 1| 3| 1| | | 2| 9| 9| 9| 3| 0| 9| 3| 4| 9| 0| 0| 9| 0| 0| 0| 1| 7| 9| 8| 9| 4| 4| 0| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Inflammation, Granulomatous | | 1 2.0| Inflammation | 2 1 1 | 11 1.1| Necrosis | 3 | 1 3.0| Pigmentation | | 1 1.0| Thrombosis | | 1 1.0| Alveolar Epithelium, Hyperplasia | 1 4 4 1 3 1 2 | 9 2.1| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Foreign Body | X X X X X | 5 | Inflammation | 1 2 2 1 3 1 1 1 1 2 | 12 1.5| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | __________________________________________________________________________|____________| Zymbal's Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infarct | | 1 4.0| Nephropathy | 1 1 1 2 1 1 2 1 2 1 1 1 2 1 2 1 1 1 2 1 2 | 42 1.4| Pigmentation | 1 1 2 1 | 13 1.2| Artery, Inflammation | | 1 2.0| Renal Tubule, Degeneration | | 1 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 _____________________________________________________________________________________________________________________ | 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| DAY ON TEST | 1| 9| 2| 2| 5| 3| 3| 0| 2| 3| 2| 3| 0| 3| 2| 3| 3| 3| 6| 2| 0| 3| 3| 0| 3| | 7| 6| 9| 9| 9| 0| 0| 8| 9| 0| 9| 0| 1| 0| 9| 0| 0| 0| 9| 9| 9| 0| 0| 3| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 10 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X X X X X X X X X X X| Clear Cell Focus | X X X X X X| Degeneration, Cystic | 1 1 1 | Eosinophilic Focus | X X X | Hematopoietic Cell Proliferation | | Hemorrhage | | Hepatodiaphragmatic Nodule | X X X | Inflammation | 1 1 1 1 1 1 1 1 1 1| Mixed Cell Focus | X X X X X X X| Necrosis | 1 | Thrombosis | | Vacuolization Cytoplasmic | 2 1 | Bile Duct, Hyperplasia | 3 2 1 1 2 1 1 2 3 3 2 1 2 2 1 2 1 1 1 2 1 1 1| Centrilobular, Degeneration | 2 2 1 4 1 1 3 2 | Centrilobular, Hypertrophy | 1 | Centrilobular, Necrosis | | __________________________________________________________________________| Mesentery | + + + + +| Hemorrhage | | Inflammation | 2 | Fat, Inflammation | 2 | Fat, Necrosis | 3 3 3| __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 1 1 1 1 2 1 2 | Cytoplasmic Alteration | 1 | Hyperplasia | 1 | Inflammation | | Duct, Hyperplasia | 1 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | | Hyperplasia | | Inflammation | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 _____________________________________________________________________________________________________________________ | 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| DAY ON TEST | 1| 9| 2| 2| 5| 3| 3| 0| 2| 3| 2| 3| 0| 3| 2| 3| 3| 3| 6| 2| 0| 3| 3| 0| 3| | 7| 6| 9| 9| 9| 0| 0| 8| 9| 0| 9| 0| 1| 0| 9| 0| 0| 0| 9| 9| 9| 0| 0| 3| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 10 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Edema | 2 | Erosion | | Ulcer | 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 2 1 2 1 1 1 1 2 1 1 1 1 2 2 1 2 2 1 2 1 1| Thrombosis | 3 3 3 | Epicardium, Hyperplasia | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Hematopoietic Cell Proliferation | | Hyperplasia | 1 2 1 2 1 1 | Hypertrophy | 1 1 | Vacuolization Cytoplasmic | 1 1 1 1 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 1 1 4 1 1 | Infiltration Cellular, Lymphocyte | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| Hyperplasia, Focal | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 4 2 3| Cyst | 2 1 1 1 1 1 | Pars Distalis, Hyperplasia | 1 1 2 2 1 3 2 4 4| Pars Intermedia, Hyperplasia | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 1 3 1 1 1 1 1 1 1 1 1 1 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | | __________________________________________________________________________| Tissue NOS | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | Mesothelium, Hyperplasia | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 2 1 2 1 1 2 2 2 2 2 2 1 1 1 2 1 1 1 2| Duct, Cyst | 2| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 _____________________________________________________________________________________________________________________ | 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| DAY ON TEST | 1| 9| 2| 2| 5| 3| 3| 0| 2| 3| 2| 3| 0| 3| 2| 3| 3| 3| 6| 2| 0| 3| 3| 0| 3| | 7| 6| 9| 9| 9| 0| 0| 8| 9| 0| 9| 0| 1| 0| 9| 0| 0| 0| 9| 9| 9| 0| 0| 3| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 10 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 1 | Inflammation | 2 3 3 3 1 1 1 1 2 3 2 3 1 3 4 1 4 3 1 2| Dorsal, Cyst, Mucous | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 4 3 | Cyst | 4 | Interstitial Cell, Hyperplasia | 1 1 3 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 3 3 2 2 3 2 2 3 3 4 | Myelofibrosis | | __________________________________________________________________________| Lymph Node | + + + + + | Inguinal, Hyperplasia, Plasma Cell | 4 | Mediastinal, Atrophy | 2 | Mediastinal, Ectasia | 1 | Mediastinal, Pigmentation | | Pancreatic, Necrosis | 4 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 2 | Hyperplasia, Plasma Cell | 3 | Necrosis | 4 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 1 | Hyperplasia, Reticulum Cell | | Necrosis | 4 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Spleen | | Fibrosis | 2 | Hematopoietic Cell Proliferation | 3 4 | Hyperplasia, Lymphoid | | Hyperplasia, Reticulum Cell | | Infarct | 4 | Pigmentation | 1 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 4 2 4 4 3 4 4 3 3 4 3 4 3 3 3 3 4 4 4 4 3 3 4 4| Artery, Inflammation | 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 2 1 1 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 _____________________________________________________________________________________________________________________ | 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| DAY ON TEST | 1| 9| 2| 2| 5| 3| 3| 0| 2| 3| 2| 3| 0| 3| 2| 3| 3| 3| 6| 2| 0| 3| 3| 0| 3| | 7| 6| 9| 9| 9| 0| 0| 8| 9| 0| 9| 0| 1| 0| 9| 0| 0| 0| 9| 9| 9| 0| 0| 3| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 10 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Cyst Epithelial Inclusion | | Hyperkeratosis | | Hyperplasia | | Inflammation | 4 | Ulcer | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteopetrosis | 3 | __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 1 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 1 1 1 1 1 1 1 1 1| Necrosis | 3 | Thrombosis | | Alveolar Epithelium, Hyperplasia | 2 1 1| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | X X X X | Inflammation | 1 1 1 2 1 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infarct | | Inflammation | 2 | Nephropathy | 1 2 3 2 1 1 1 1 1 1 2 1 1 1 1 2 1 2 1 1 1 1 2 2 1| Pigmentation | 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 7| 4| 5| 6| 5| 5| 3| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| | DAY ON TEST | 2| 2| 8| 3| 3| 2| 2| 2| 1| 8| 6| 1| 9| 8| 6| 2| 1| 8| 2| 3| 2| 3| 3| 2| 2| | | 9| 9| 5| 0| 0| 9| 3| 9| 0| 5| 3| 2| 2| 6| 3| 9| 8| 7| 9| 0| 9| 0| 9| 9| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 10 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X X | 4 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X X | 6 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X X X X X X X X X X X | 29 | Clear Cell Focus | X X X X X| 11 | Degeneration, Cystic | 1 | 4 1.0| Eosinophilic Focus | X X X X X | 8 | Hematopoietic Cell Proliferation | 1 | 1 1.0| Hemorrhage | 2 | 1 2.0| Hepatodiaphragmatic Nodule | X X | 5 | Inflammation | 1 1 1 2 1 1 1 1 1 1 1 1 1 2 1 1 1| 27 1.1| Mixed Cell Focus | X X X X X X X X X X| 17 | Necrosis | | 1 1.0| Thrombosis | 4 | 1 4.0| Vacuolization Cytoplasmic | 1 1 | 4 1.3| Bile Duct, Hyperplasia | 1 1 1 2 1 1 3 1 1 2 2 1 1 1 1 2 2 2 2 1 1 1 2 2| 47 1.5| Centrilobular, Degeneration | 2 3 1 2 4 1 2 | 15 2.1| Centrilobular, Hypertrophy | | 1 1.0| Centrilobular, Necrosis | 3 | 1 3.0| __________________________________________________________________________|____________| Mesentery | + + + + + + +| 12 | Hemorrhage | 4 | 1 4.0| Inflammation | | 1 2.0| Fat, Inflammation | | 1 2.0| Fat, Necrosis | 3 3 3 3| 7 3.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 2 1 1 2 1 2 | 14 1.4| Cytoplasmic Alteration | 1 | 2 1.0| Hyperplasia | 2 | 2 1.5| Inflammation | 1 1 1 1 | 4 1.0| Duct, Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 7| 4| 5| 6| 5| 5| 3| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| | DAY ON TEST | 2| 2| 8| 3| 3| 2| 2| 2| 1| 8| 6| 1| 9| 8| 6| 2| 1| 8| 2| 3| 2| 3| 3| 2| 2| | | 9| 9| 5| 0| 0| 9| 3| 9| 0| 5| 3| 2| 2| 6| 3| 9| 8| 7| 9| 0| 9| 0| 9| 9| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 10 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | 3 | 1 3.0| Hyperplasia | 2 2 | 2 2.0| Inflammation | 1 | 1 1.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | | 1 2.0| Erosion | 1 | 1 1.0| Ulcer | 1 | 2 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 2 1 2 2 1 2 1 1 1 1 1 1 1 2 1 1 1 1 2 2 1 2 2| 46 1.4| Thrombosis | 2 4 | 5 3.0| Epicardium, Hyperplasia | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 1 | 1 1.0| Hematopoietic Cell Proliferation | 1 | 1 1.0| Hyperplasia | 1 2 1 2 1 2 1| 13 1.4| Hypertrophy | 1 1 1 2 1| 7 1.1| Vacuolization Cytoplasmic | 1 1 | 6 1.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 1 3 1 | 10 1.6| Infiltration Cellular, Lymphocyte | 2 | 1 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 4 | 1 4.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 48 | Hyperplasia, Focal | 1 | 1 1.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 2 | 6 2.5| Cyst | 1 1 | 8 1.1| Pars Distalis, Hyperplasia | 2 2 2 1 1 1 1 2| 17 1.9| Pars Intermedia, Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 4 1 1 1 1 1 1 1 1 1 1 1 2 1 2| 30 1.3| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 7| 4| 5| 6| 5| 5| 3| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| | DAY ON TEST | 2| 2| 8| 3| 3| 2| 2| 2| 1| 8| 6| 1| 9| 8| 6| 2| 1| 8| 2| 3| 2| 3| 3| 2| 2| | | 9| 9| 5| 0| 0| 9| 3| 9| 0| 5| 3| 2| 2| 6| 3| 9| 8| 7| 9| 0| 9| 0| 9| 9| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 10 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Peritoneum | + | 1 | __________________________________________________________________________|____________| Tissue NOS | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 | 1 2.0| Mesothelium, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation | 2 1 2 2 1 2 2 1 1 2 2 1 2 2 2 2 2 1 2 1 1 2 1 2| 45 1.6| Duct, Cyst | 1 1| 3 1.3| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 1.0| Inflammation | 1 1 3 2 2 1 1 1 1 3 1 3 3 4 2 3 1 1| 38 2.1| Dorsal, Cyst, Mucous | 3 | 1 3.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 4 4 4 4 | 7 3.9| Cyst | | 1 4.0| Interstitial Cell, Hyperplasia | 2 1 1 1 1 2 1 4 2 1 1 1 1 1 1 1 1 1| 37 1.2| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 3 2 2 2 2 1 | 18 2.4| Myelofibrosis | 3 2 | 2 2.5| __________________________________________________________________________|____________| Lymph Node | + + + + + + | 11 | Inguinal, Hyperplasia, Plasma Cell | | 1 4.0| Mediastinal, Atrophy | | 1 2.0| Mediastinal, Ectasia | | 1 1.0| Mediastinal, Pigmentation | 4 | 1 4.0| Pancreatic, Necrosis | | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 2 2 1 1 | 5 1.6| Hyperplasia, Plasma Cell | | 1 3.0| Necrosis | | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | | 1 1.0| Hyperplasia, Reticulum Cell | 2 1 | 2 1.5| Necrosis | | 1 4.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 7| 4| 5| 6| 5| 5| 3| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| | DAY ON TEST | 2| 2| 8| 3| 3| 2| 2| 2| 1| 8| 6| 1| 9| 8| 6| 2| 1| 8| 2| 3| 2| 3| 3| 2| 2| | | 9| 9| 5| 0| 0| 9| 3| 9| 0| 5| 3| 2| 2| 6| 3| 9| 8| 7| 9| 0| 9| 0| 9| 9| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 10 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Accessory Spleen | X | 1 | Fibrosis | 1 1 2| 4 1.5| Hematopoietic Cell Proliferation | 3 2 2 | 5 2.8| Hyperplasia, Lymphoid | 4 | 1 4.0| Hyperplasia, Reticulum Cell | 4 | 1 4.0| Infarct | | 1 4.0| Pigmentation | 2 | 2 1.5| __________________________________________________________________________|____________| Thymus | M + + + + + + M + + + + M + + + + + + + + + + + +| 47 | Atrophy | 3 4 3 4 4 4 4 4 2 3 4 3 3 4 3 3 4 3 4 4| 45 3.5| Artery, Inflammation | | 1 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 1 1 1 | 8 1.1| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst Epithelial Inclusion | X | 1 | Hyperkeratosis | 2 | 1 2.0| Hyperplasia | 2 | 1 2.0| Inflammation | | 1 4.0| Ulcer | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteopetrosis | | 1 3.0| __________________________________________________________________________|____________| Skeletal Muscle | + + | 2 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 1 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation | 1 1 1 1 1 | 16 1.0| Necrosis | | 1 3.0| Thrombosis | 1 | 1 1.0| Alveolar Epithelium, Hyperplasia | 1 3 2 1 | 7 1.6| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Foreign Body | X X | 6 | Inflammation | 1 1 1 | 9 1.1| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 7| 4| 5| 6| 5| 5| 3| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| | DAY ON TEST | 2| 2| 8| 3| 3| 2| 2| 2| 1| 8| 6| 1| 9| 8| 6| 2| 1| 8| 2| 3| 2| 3| 3| 2| 2| | | 9| 9| 5| 0| 0| 9| 3| 9| 0| 5| 3| 2| 2| 6| 3| 9| 8| 7| 9| 0| 9| 0| 9| 9| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 10 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation | | 1 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Zymbal's Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infarct | 2 | 1 2.0| Inflammation | 1 | 2 1.5| Nephropathy | 1 2 1 3 1 3 2 1 1 2 1 1 1 1 2 1 3 2 1 1 2 1 2| 48 1.5| Pigmentation | 2 1 1 | 4 1.3| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 4| 7| 7| 7| 5| 7| 5| 6| 7| 7| 6| 7| DAY ON TEST | 5| 2| 3| 2| 3| 1| 2| 0| 9| 1| 2| 2| 3| 0| 3| 3| 2| 8| 3| 2| 2| 2| 2| 9| 2| | 7| 3| 0| 9| 0| 5| 9| 8| 1| 4| 9| 9| 0| 0| 0| 0| 9| 5| 0| 3| 1| 1| 5| 1| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 30 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 | Parasite Metazoan | X X X X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Ulcer | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 | Basophilic Focus | X X X X X X X X X X X X X X X X| Clear Cell Focus | X X| Degeneration, Cystic | 1 1 1 | Eosinophilic Focus | X X X X | Fibrosis | | Hematopoietic Cell Proliferation | 1 | Hemorrhage | | Hepatodiaphragmatic Nodule | X X X X X | Inflammation | 1 1 1 1 1 1 2 2 1 1 1 1 1| Mixed Cell Focus | X X X X| Necrosis | 1 | Thrombosis | 2 | Vacuolization Cytoplasmic | 1 2 | Bile Duct, Hyperplasia | 4 1 2 3 1 1 1 1 1 2 2 2 1 2 1 1 1 3 1 1 1| Centrilobular, Degeneration | 3 3 2 3 2 1 | Centrilobular, Hypertrophy | 1 1 1| Centrilobular, Necrosis | 3 | __________________________________________________________________________| Mesentery | + + + + + + | Hemorrhage | 4 | Inflammation | 2 | Fat, Necrosis | 2 3 2 3 | __________________________________________________________________________| Oral Mucosa | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 1 1 1 2 1 1 2 1| Inflammation | 1 1 1 1 | Necrosis | | Thrombosis | | Artery, Inflammation | 2 | Duct, Cyst | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 4| 7| 7| 7| 5| 7| 5| 6| 7| 7| 6| 7| DAY ON TEST | 5| 2| 3| 2| 3| 1| 2| 0| 9| 1| 2| 2| 3| 0| 3| 3| 2| 8| 3| 2| 2| 2| 2| 9| 2| | 7| 3| 0| 9| 0| 5| 9| 8| 1| 4| 9| 9| 0| 0| 0| 0| 9| 5| 0| 3| 1| 1| 5| 1| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 30 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 2 | Hyperplasia | 1 | Ulcer | 1 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | 1 1 | Mineralization | | Ulcer | 1 1 | __________________________________________________________________________| Tooth | | Gingiva, Inflammation | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 2 1 1 2 1 1 1 2 2 2 1 1 1 1 2 1 2 1 3| Thrombosis | 3 4 2| Artery, Inflammation | 2 | Endocardium, Degeneration | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 1| Atrophy | | Hyperplasia | 2 1 1 2 1| Hypertrophy | 1 1 | Vacuolization Cytoplasmic | 2 3 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Hyperplasia | 1 1 1 4 2 2 2 2| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + M + + + + M + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 2 3 | Cyst | 1 1 1 | Hemorrhage | 4 | Pars Distalis, Hyperplasia | 4 2 3 1 2 3 2 3 1 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 1 1 2 2 2 1 4 1 1 1 1 1 1| Follicular Cell, Hyperplasia | 2 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 4| 7| 7| 7| 5| 7| 5| 6| 7| 7| 6| 7| DAY ON TEST | 5| 2| 3| 2| 3| 1| 2| 0| 9| 1| 2| 2| 3| 0| 3| 3| 2| 8| 3| 2| 2| 2| 2| 9| 2| | 7| 3| 0| 9| 0| 5| 9| 8| 1| 4| 9| 9| 0| 0| 0| 0| 9| 5| 0| 3| 1| 1| 5| 1| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 30 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 | Mesothelium, Hyperplasia | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 3 4 | Inflammation | 2 2 1 2 2 1 1 1 1 2 1 2 2 2 2 1 2 2 1 2 2 2 2 2| Duct, Cyst | 3 4 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 4 2 3 1 1 3 1 2 3 2 3 1 3 | Dorsal, Cyst, Mucous | 3 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 4 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 4 | Interstitial Cell, Hyperplasia | 1 2 1 2 2 1 2 1 1 1 1 1 1 2 2 1 | Mesothelium, Hyperplasia | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 3 2 3 2 2 3 2| Inflammation, Granulomatous | 1 | Myelofibrosis | | Necrosis | 4 | __________________________________________________________________________| Lymph Node | + + + + + + | Mediastinal, Pigmentation | 1 1 3 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 1 2 1 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 1 1 | Hematopoietic Cell Proliferation | 2 1 | Hyperplasia, Reticulum Cell | 4 | Infarct | | Infiltration Cellular, Lipocyte | 2 | Pigmentation | 2 | Lymphoid Follicle, Atrophy | 3 | __________________________________________________________________________| Thymus | + + + M + + + + + + + + + M + + + + + + + + + + M| Atrophy | 4 4 3 3 3 3 3 4 3 3 3 3 3 4 4 4 3 4 4 4 3 | Epithelial Cell, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | Hyperplasia | 1 1 2 1 1 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 4| 7| 7| 7| 5| 7| 5| 6| 7| 7| 6| 7| DAY ON TEST | 5| 2| 3| 2| 3| 1| 2| 0| 9| 1| 2| 2| 3| 0| 3| 3| 2| 8| 3| 2| 2| 2| 2| 9| 2| | 7| 3| 0| 9| 0| 5| 9| 8| 1| 4| 9| 9| 0| 0| 0| 0| 9| 5| 0| 3| 1| 1| 5| 1| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 30 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Inflammation | 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 3 | Inflammation | 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Gliosis | | Hemorrhage | 1 2 | Necrosis | 1 2 2 | Thrombosis | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | | Foreign Body | X | Hemorrhage | 1 | Inflammation | 1 1 1 1 1 1 1 1 | Thrombosis | 1 | Alveolar Epithelium, Hyperplasia | 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | X | Inflammation | 2 2 1 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | +| Cataract | 2| Retina, Degeneration | 3| __________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infarct | 2 | Necrosis | 4 | Nephropathy | 1 1 1 2 1 2 2 1 1 1 1 2 2 1 2 1 1 1 1 2 1 1 2| Pigmentation | 1 1 1 1 1 | Thrombosis | | Pelvis, Inflammation | | __________________________________________________________________________| Urethra | + | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 4| 7| 7| 7| 5| 7| 5| 6| 7| 7| 6| 7| DAY ON TEST | 5| 2| 3| 2| 3| 1| 2| 0| 9| 1| 2| 2| 3| 0| 3| 3| 2| 8| 3| 2| 2| 2| 2| 9| 2| | 7| 3| 0| 9| 0| 5| 9| 8| 1| 4| 9| 9| 0| 0| 0| 0| 9| 5| 0| 3| 1| 1| 5| 1| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 30 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Inflammation | 4 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 3 1 | Transitional Epithelium, Hyperplasia | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 6| 7| 6| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 5| 6| 4| 6| 4| 7| | DAY ON TEST | 6| 3| 2| 3| 3| 1| 4| 2| 5| 3| 8| 0| 3| 7| 0| 3| 0| 2| 6| 4| 7| 8| 0| 4| 0| | | 2| 0| 9| 0| 0| 2| 6| 9| 3| 7| 2| 8| 0| 5| 8| 0| 1| 9| 3| 9| 6| 2| 2| 4| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 30 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation | | 2 1.0| Parasite Metazoan | X X X X | 8 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 2 | 1 2.0| Ulcer | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation | 2 | 1 2.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 1 1.0| Basophilic Focus | X X X X X X X X X X | 26 | Clear Cell Focus | | 2 | Degeneration, Cystic | 1 | 4 1.0| Eosinophilic Focus | X X | 6 | Fibrosis | 1 | 1 1.0| Hematopoietic Cell Proliferation | | 1 1.0| Hemorrhage | 1 | 1 1.0| Hepatodiaphragmatic Nodule | X X X X X | 10 | Inflammation | 1 1 1 1 2 1 | 19 1.2| Mixed Cell Focus | X X X X| 8 | Necrosis | 1 1 | 3 1.0| Thrombosis | 2 | 2 2.0| Vacuolization Cytoplasmic | | 2 1.5| Bile Duct, Hyperplasia | 3 1 2 3 1 3 2 1 2 2 1 2 1 2 2 2 3 2 3 1 1 1 3| 44 1.8| Centrilobular, Degeneration | 1 1 4 2 2 1 1 2 1 3 2 1 2 4| 20 2.1| Centrilobular, Hypertrophy | | 3 1.0| Centrilobular, Necrosis | | 1 3.0| __________________________________________________________________________|____________| Mesentery | + + + + + + | 12 | Hemorrhage | | 1 4.0| Inflammation | | 1 2.0| Fat, Necrosis | 2 3 3 3 | 8 2.6| __________________________________________________________________________|____________| Oral Mucosa | + | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 1 2 1 1 | 13 1.2| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 6| 7| 6| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 5| 6| 4| 6| 4| 7| | DAY ON TEST | 6| 3| 2| 3| 3| 1| 4| 2| 5| 3| 8| 0| 3| 7| 0| 3| 0| 2| 6| 4| 7| 8| 0| 4| 0| | | 2| 0| 9| 0| 0| 2| 6| 9| 3| 7| 2| 8| 0| 5| 8| 0| 1| 9| 3| 9| 6| 2| 2| 4| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 30 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Inflammation | | 4 1.0| Necrosis | 2 | 1 2.0| Thrombosis | 1 | 1 1.0| Artery, Inflammation | 3 | 2 2.5| Duct, Cyst | 1 | 1 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 2.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | | 1 2.0| Hyperplasia | | 1 1.0| Ulcer | 2 1| 3 1.3| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Erosion | 1 1| 4 1.0| Mineralization | 1 | 1 1.0| Ulcer | 3 1 | 4 1.5| __________________________________________________________________________|____________| Tooth | + | 1 | Gingiva, Inflammation | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 2 2 1 2 2 1 1 1 1 1 2 2 2 2 1 1 1 2 2 1 1 | 43 1.4| Thrombosis | 2 4| 5 3.0| Artery, Inflammation | | 1 2.0| Endocardium, Degeneration | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 2 1.0| Atrophy | 2 | 1 2.0| Hyperplasia | 1 1 1 | 8 1.3| Hypertrophy | 1 | 3 1.0| Vacuolization Cytoplasmic | 2 1 | 4 2.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 4 | 1 4.0| Hyperplasia | 3 2 1 4 3 4 1| 15 2.2| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 6| 7| 6| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 5| 6| 4| 6| 4| 7| | DAY ON TEST | 6| 3| 2| 3| 3| 1| 4| 2| 5| 3| 8| 0| 3| 7| 0| 3| 0| 2| 6| 4| 7| 8| 0| 4| 0| | | 2| 0| 9| 0| 0| 2| 6| 9| 3| 7| 2| 8| 0| 5| 8| 0| 1| 9| 3| 9| 6| 2| 2| 4| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 30 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Angiectasis | 1 2 4| 6 2.3| Cyst | 1 1 1 1 1 1 1 | 10 1.0| Hemorrhage | 2 | 2 3.0| Pars Distalis, Hyperplasia | 2 4 1 2 2 1 2 2 4 1 2| 21 2.2| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 4 1 1 1 1 1 2 2 1 1 1 1 | 26 1.5| Follicular Cell, Hyperplasia | 2 | 3 1.7| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation | | 1 1.0| Mesothelium, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 3 | 4 3.5| Inflammation | 2 2 1 1 2 2 2 1 2 2 2 1 2 1 1 2 1 2 2 1 1 1 2 2| 48 1.6| Duct, Cyst | | 2 3.5| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation | 2 1 1 2 1 1 1 2 2 2 1 2 3 1 3 2 1| 31 1.9| Dorsal, Cyst, Mucous | | 1 3.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation | | 1 4.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 2 | 3 3.3| Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 | 28 1.2| Mesothelium, Hyperplasia | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 3 2 3 4 3 2 2 2 | 16 2.6| Inflammation, Granulomatous | | 1 1.0| Myelofibrosis | 3 | 1 3.0| Necrosis | | 1 4.0| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + | 14 | Mediastinal, Pigmentation | 4 | 4 2.3| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 | Ectasia | | 3 1.3| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 6| 7| 6| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 5| 6| 4| 6| 4| 7| | DAY ON TEST | 6| 3| 2| 3| 3| 1| 4| 2| 5| 3| 8| 0| 3| 7| 0| 3| 0| 2| 6| 4| 7| 8| 0| 4| 0| | | 2| 0| 9| 0| 0| 2| 6| 9| 3| 7| 2| 8| 0| 5| 8| 0| 1| 9| 3| 9| 6| 2| 2| 4| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 30 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 2 1 | 4 1.3| Hematopoietic Cell Proliferation | 3 | 3 2.0| Hyperplasia, Reticulum Cell | | 1 4.0| Infarct | 2 | 1 2.0| Infiltration Cellular, Lipocyte | | 1 2.0| Pigmentation | 2 | 2 2.0| Lymphoid Follicle, Atrophy | 2 2 | 3 2.3| __________________________________________________________________________|____________| Thymus | + + + M + + + + + + + + + + + + + + + + + + + + +| 46 | Atrophy | 3 4 4 4 4 3 4 3 4 3 4 4 4 4 4 4 2 4 4| 40 3.6| Epithelial Cell, Hyperplasia | | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 | Cyst | | 1 2.0| Hyperplasia | 1 2 1 1| 9 1.2| Inflammation | | 1 2.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | | 1 3.0| Inflammation | | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Gliosis | 2| 1 2.0| Hemorrhage | 3 2 | 4 2.0| Necrosis | 2 | 4 1.8| Thrombosis | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | 1 | 1 1.0| Foreign Body | | 1 | Hemorrhage | 1 2 | 3 1.3| Inflammation | 1 1 2 1 1 2 | 14 1.1| Thrombosis | 1 | 2 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 6| 7| 6| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 5| 6| 4| 6| 4| 7| | DAY ON TEST | 6| 3| 2| 3| 3| 1| 4| 2| 5| 3| 8| 0| 3| 7| 0| 3| 0| 2| 6| 4| 7| 8| 0| 4| 0| | | 2| 0| 9| 0| 0| 2| 6| 9| 3| 7| 2| 8| 0| 5| 8| 0| 1| 9| 3| 9| 6| 2| 2| 4| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 30 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Alveolar Epithelium, Hyperplasia | 4 | 2 2.5| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Foreign Body | X X | 3 | Inflammation | 2 1 | 6 1.5| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | Cataract | | 1 2.0| Retina, Degeneration | | 1 3.0| __________________________________________________________________________|____________| Zymbal's Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infarct | 2 1 | 3 1.7| Necrosis | 3 | 2 3.5| Nephropathy | 2 2 2 2 1 1 1 1 1 2 1 2 1 1 2 1 1 1| 41 1.4| Pigmentation | 1 2 1 2 1 1 1 2 2 1 | 15 1.3| Thrombosis | 4 | 1 4.0| Pelvis, Inflammation | 2 | 1 2.0| __________________________________________________________________________|____________| Urethra | | 1 | Inflammation | | 1 4.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation | | 2 2.0| Transitional Epithelium, Hyperplasia | 1 1 | 2 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 5| 7| 6| 5| 6| 6| 7| 6| 6| 5| 7| 7| 7| 7| 4| DAY ON TEST | 2| 2| 2| 2| 9| 9| 2| 3| 3| 3| 6| 2| 7| 8| 5| 1| 3| 3| 3| 6| 2| 2| 3| 0| 9| | 9| 9| 9| 9| 0| 9| 9| 7| 0| 0| 2| 9| 6| 5| 9| 0| 0| 2| 4| 9| 3| 9| 0| 1| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 100 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | Ulcer | 1 | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 2 | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X X X X X X X X X X| Clear Cell Focus | X X | Degeneration, Cystic | 1 1 | Eosinophilic Focus | X X X X X X | Fibrosis | 1 | Hematopoietic Cell Proliferation | 1 | Hemorrhage | 2 | Hepatodiaphragmatic Nodule | X | Inflammation | 1 1 1 1 1 1 1 1 1 1| Mixed Cell Focus | X X X X X X | Necrosis | 1 3 2 | Vacuolization Cytoplasmic | 2 1 | Bile Duct, Hyperplasia | 2 1 2 2 2 2 2 1 2 1 1 2 3 3 3 1 3 3 3 2 1 2 3 1| Centrilobular, Degeneration | 2 1 2 2 2 2 2 2 2 4 4 | Centrilobular, Hypertrophy | 1 2 2 1 2 2 1 1 | __________________________________________________________________________| Mesentery | + + + + + + + | Fat, Inflammation | 1 | Fat, Necrosis | 3 3 2 3 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 1 2 1 1 | Cytoplasmic Alteration | | Hyperplasia | 2 | Inflammation | 1 | Duct, Cyst | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Cytoplasmic Alteration | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | | Ulcer | 3 4 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | 1 2 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 5| 7| 6| 5| 6| 6| 7| 6| 6| 5| 7| 7| 7| 7| 4| DAY ON TEST | 2| 2| 2| 2| 9| 9| 2| 3| 3| 3| 6| 2| 7| 8| 5| 1| 3| 3| 3| 6| 2| 2| 3| 0| 9| | 9| 9| 9| 9| 0| 9| 9| 7| 0| 0| 2| 9| 6| 5| 9| 0| 0| 2| 4| 9| 3| 9| 0| 1| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 100 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Mineralization | 2 | Necrosis | 3 | Ulcer | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Aorta, Inflammation | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 2 1 1 2 1 1 2 1 1 2 1 1 1 1 1 1 2 1 1 2 1| Thrombosis | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Degeneration, Cystic | | Hyperplasia | 1| Hypertrophy | 1 | Vacuolization Cytoplasmic | 1 1 1 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 1 4 1 3 1 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | M + + + + + + + M + + + + M M + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 4 2 | Cyst | 1 2 | Pars Distalis, Hyperplasia | 2 2 1 2 1 2 2 | Pars Distalis, Pseudocyst | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 1 1 2 1 4 2 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | Inflammation | 2 2 2 2 2 2 1 2 1 2 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2| Duct, Cyst | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 3 2 2 1 2 3 2 1 3 2 1 2 2 2 1 1| Dorsal, Cyst, Mucous | 3 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 5| 7| 6| 5| 6| 6| 7| 6| 6| 5| 7| 7| 7| 7| 4| DAY ON TEST | 2| 2| 2| 2| 9| 9| 2| 3| 3| 3| 6| 2| 7| 8| 5| 1| 3| 3| 3| 6| 2| 2| 3| 0| 9| | 9| 9| 9| 9| 0| 9| 9| 7| 0| 0| 2| 9| 6| 5| 9| 0| 0| 2| 4| 9| 3| 9| 0| 1| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 100 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Atrophy | 4 4 4 | Interstitial Cell, Hyperplasia | 2 3 3 1 2 1 1 1 1 1 1 4 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 3 3 4 2 2 3 3 2 1 3 | Myelofibrosis | 1 | __________________________________________________________________________| Lymph Node | + + + + + + +| Mediastinal, Hemorrhage | 3| Mediastinal, Pigmentation | 4 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 2 1 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 | Ectasia | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Spleen | | Fibrosis | 1 1 2 1 | Hematopoietic Cell Proliferation | 3 3 3 2 | Infarct | | Necrosis | 2 | Pigmentation | 1 | Lymphoid Follicle, Atrophy | 3 3| __________________________________________________________________________| Thymus | + + + + M + + + + + + + + + + M + + + + + + + + +| Atrophy | 4 3 4 4 3 4 4 3 3 4 4 4 4 4 4 4 4 4 3 3 4 4 3| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Galactocele | | Hyperplasia | 1 2 1 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 3 | Hyperkeratosis | | Inflammation | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteopetrosis | | __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Gliosis | 1 | Hemorrhage | 2 2 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 5| 7| 6| 5| 6| 6| 7| 6| 6| 5| 7| 7| 7| 7| 4| DAY ON TEST | 2| 2| 2| 2| 9| 9| 2| 3| 3| 3| 6| 2| 7| 8| 5| 1| 3| 3| 3| 6| 2| 2| 3| 0| 9| | 9| 9| 9| 9| 0| 9| 9| 7| 0| 0| 2| 9| 6| 5| 9| 0| 0| 2| 4| 9| 3| 9| 0| 1| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 100 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 2 | Foreign Body | | Hemorrhage | 1 2 | Inflammation | 1 1 1 1 1 1 1 1 3 1 1 3 | Alveolar Epithelium, Hyperplasia | 4 1 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | X X X | Inflammation | 1 1 1 1 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Cataract | 2 | Retina, Degeneration | 4 | __________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infarct | 1 | Nephropathy | 2 2 1 1 1 2 1 3 2 1 2 1 2 2 1 2 2 1 1 1 1 1 | Pigmentation | 1 1 2 3 1 3 3 1 3 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| | DAY ON TEST | 2| 2| 3| 3| 2| 2| 6| 0| 3| 7| 2| 2| 3| 3| 2| 3| 9| 3| 3| 2| 2| 3| 3| 2| 6| | | 9| 2| 0| 0| 9| 9| 9| 2| 3| 7| 9| 9| 0| 0| 9| 0| 1| 0| 0| 9| 9| 0| 0| 9| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 100 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X | 2 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X X X X| 7 | Ulcer | | 1 1.0| __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation | | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation | 1 | 1 1.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X X X X X X X X X X| 27 | Clear Cell Focus | X X | 4 | Degeneration, Cystic | 1 1 1 2 | 6 1.2| Eosinophilic Focus | X X | 8 | Fibrosis | | 1 1.0| Hematopoietic Cell Proliferation | | 1 1.0| Hemorrhage | | 1 2.0| Hepatodiaphragmatic Nodule | X X X | 4 | Inflammation | 1 1 2 1 1 1 1 1 1 1 1| 21 1.0| Mixed Cell Focus | X X X X X | 11 | Necrosis | 1 | 4 1.8| Vacuolization Cytoplasmic | 1 1 1 | 5 1.2| Bile Duct, Hyperplasia | 2 2 1 1 2 1 3 1 3 3 2 1 2 3 1 1 2 1 1 3 2 2 1 1| 48 1.9| Centrilobular, Degeneration | 2 4 2 3 1 3 2 2 2 2 1 1 | 23 2.2| Centrilobular, Hypertrophy | 1 2 1 1 1 1 1 1| 16 1.3| __________________________________________________________________________|____________| Mesentery | + + + + + + +| 14 | Fat, Inflammation | 3 | 2 2.0| Fat, Necrosis | 2 3 3 | 7 2.7| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 1 1 1 1 1 1 1 | 12 1.1| Cytoplasmic Alteration | 1 | 1 1.0| Hyperplasia | 3 | 2 2.5| Inflammation | 1 | 2 1.0| Duct, Cyst | 1 | 1 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cytoplasmic Alteration | 1 1 | 2 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| | DAY ON TEST | 2| 2| 3| 3| 2| 2| 6| 0| 3| 7| 2| 2| 3| 3| 2| 3| 9| 3| 3| 2| 2| 3| 3| 2| 6| | | 9| 2| 0| 0| 9| 9| 9| 2| 3| 7| 9| 9| 0| 0| 9| 0| 1| 0| 0| 9| 9| 0| 0| 9| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 100 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | 2 | 1 2.0| Ulcer | | 2 3.5| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Erosion | 1 | 3 1.3| Mineralization | | 1 2.0| Necrosis | | 1 3.0| Ulcer | 1 1 | 2 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Aorta, Inflammation | 2 | 1 2.0| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 2 2 2 2 2 2 1 2 1 2 1 1 1 2 1 1 2 2 2 1| 43 1.4| Thrombosis | 3 | 2 2.5| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 1 | 1 1.0| Degeneration, Cystic | 1 | 1 1.0| Hyperplasia | 1 1 1 2 1 1 1 1 | 9 1.1| Hypertrophy | 1 | 2 1.0| Vacuolization Cytoplasmic | | 3 1.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 4 1 1 2 | 12 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 | 3 2.7| Cyst | 1 1 1 1| 6 1.2| Pars Distalis, Hyperplasia | 4 2 1 2 3 4 1 1| 15 2.0| Pars Distalis, Pseudocyst | 2 | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 1 1 1 1 2 1 4 2 1 4 1 | 20 1.7| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Peritoneum | +| 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| | DAY ON TEST | 2| 2| 3| 3| 2| 2| 6| 0| 3| 7| 2| 2| 3| 3| 2| 3| 9| 3| 3| 2| 2| 3| 3| 2| 6| | | 9| 2| 0| 0| 9| 9| 9| 2| 3| 7| 9| 9| 0| 0| 9| 0| 1| 0| 0| 9| 9| 0| 0| 9| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 100 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 3 4 | 2 3.5| Inflammation | 2 2 2 2 2 2 2 2 2 1 1 1 1 1 2 1 2 2 2 2 2 1 2| 48 1.7| Duct, Cyst | 2 4 | 2 3.0| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation | 1 3 1 1 3 2 3 1 2 2 3 2| 29 1.9| Dorsal, Cyst, Mucous | | 1 3.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 4 4 4 | 6 4.0| Interstitial Cell, Hyperplasia | 2 1 1 1 1 1 1 1 1 1 1| 24 1.4| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 3 2 2 2 3 2 3 3 2| 20 2.5| Myelofibrosis | 2 | 2 1.5| __________________________________________________________________________|____________| Lymph Node | + + + + + + +| 14 | Mediastinal, Hemorrhage | | 1 3.0| Mediastinal, Pigmentation | 2 3| 3 3.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | | 2 1.5| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + + + + + +| 49 | Atrophy | | 1 3.0| Ectasia | 4 | 1 4.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Spleen | X X | 2 | Fibrosis | 2 | 5 1.4| Hematopoietic Cell Proliferation | 3 | 5 2.8| Infarct | 2 | 1 2.0| Necrosis | | 1 2.0| Pigmentation | | 1 1.0| Lymphoid Follicle, Atrophy | | 2 3.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +| 47 | Atrophy | 3 4 3 3 3 4 4 4 3 3 3 3 3 3 3 3 4 3 4 4| 43 3.5| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Galactocele | 1 4 | 2 2.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| | DAY ON TEST | 2| 2| 3| 3| 2| 2| 6| 0| 3| 7| 2| 2| 3| 3| 2| 3| 9| 3| 3| 2| 2| 3| 3| 2| 6| | | 9| 2| 0| 0| 9| 9| 9| 2| 3| 7| 9| 9| 0| 0| 9| 0| 1| 0| 0| 9| 9| 0| 0| 9| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 100 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | Hyperplasia | 1 1 4 | 6 1.7| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | | 1 3.0| Hyperkeratosis | 2 | 1 2.0| Inflammation | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteopetrosis | 3 | 1 3.0| __________________________________________________________________________|____________| Skeletal Muscle | +| 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Gliosis | | 1 1.0| Hemorrhage | 1 | 3 1.7| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | | 1 2.0| Foreign Body | X | 1 | Hemorrhage | 1 1 | 4 1.3| Inflammation | 1 2 1 1 1 1 | 18 1.3| Alveolar Epithelium, Hyperplasia | 2 1 | 5 1.8| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Foreign Body | X X | 5 | Inflammation | 1 2 1 | 8 1.1| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | Cataract | | 1 2.0| Retina, Degeneration | | 1 4.0| __________________________________________________________________________|____________| Zymbal's Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infarct | | 1 1.0| Nephropathy | 1 2 2 2 1 2 1 1 2 2 1 2 2 1 2 1 2 1 1 3 2 1| 44 1.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:57:41 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| | DAY ON TEST | 2| 2| 3| 3| 2| 2| 6| 0| 3| 7| 2| 2| 3| 3| 2| 3| 9| 3| 3| 2| 2| 3| 3| 2| 6| | | 9| 2| 0| 0| 9| 9| 9| 2| 3| 7| 9| 9| 0| 0| 9| 0| 1| 0| 0| 9| 9| 0| 0| 9| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 100 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Pigmentation | 1 1 1 1 1 1 1 1 1 | 19 1.5| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked 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