TDMS Study 88120-03 Pathology Tables
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
FINAL #1 CORE STUDY RATS
Facility: Battelle Columbus Laboratory
Chemical CAS #: 80-07-9
Lock Date: 08/11/98
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 6| 5| 4| 3| 3| 3| 3| 3| 9| 2| 3| 3| 2|
| 0| 1| 0| 2| 1| 0| 0| 3| 2| 2| 2| 2| 5| 6| 3| 1| 0| 1| 0| 2| 4| 9| 2| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X |
Eosinophilic Focus | X X X X X |
Fatty Change | 4 |
Hemorrhage | |
Hepatodiaphragmatic Nodule | X X X X|
Inflammation | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1|
Mixed Cell Focus | X X |
Necrosis | 4 |
Vacuolization Cytoplasmic | 1 1 |
Bile Duct, Hyperplasia | 1 2 2 |
Centrilobular, Degeneration | |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 1 1 |
Inflammation | 1 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Cytoplasmic Alteration | 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 1 |
Inflammation | |
Ulcer | 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation | 1 1 1 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 6| 5| 4| 3| 3| 3| 3| 3| 9| 2| 3| 3| 2|
| 0| 1| 0| 2| 1| 0| 0| 3| 2| 2| 2| 2| 5| 6| 3| 1| 0| 1| 0| 2| 4| 9| 2| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 1 1 1 1 1 2 |
Degeneration, Cystic | 1 2 |
Hyperplasia | 1 1 2 1 1 1 |
Hypertrophy | 1 1 |
Vacuolization Cytoplasmic | 1 4 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + + M + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 4 2 2 1 2 2 2 3|
Cyst | 1 |
Pars Distalis, Hyperplasia | 4 1 3 4 2 1 1 3 1 2 1 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3 1 1 1 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + M + + M|
Hyperplasia | 1 1 2 |
Inflammation | 1 1 1 1 1 1 1 1 |
Duct, Cyst | 1 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | 3 4 |
Inflammation | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 4 |
Cervix, Inflammation | |
Endometrium, Hyperplasia, Cystic | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 4 2 2 3 |
Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + +|
Mediastinal, Pigmentation | 1 1 1 1 1 2 1 1 1 2 2|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 6| 5| 4| 3| 3| 3| 3| 3| 9| 2| 3| 3| 2|
| 0| 1| 0| 2| 1| 0| 0| 3| 2| 2| 2| 2| 5| 6| 3| 1| 0| 1| 0| 2| 4| 9| 2| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 3 |
Pigmentation | 2 2 2 1 3 2 1 2 2 1 2|
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + + M + + + + + M + + +|
Atrophy | 4 4 3 4 4 4 3 3 3 4 4 4 3 3 3 4 3 3 4 4 3 4|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Galactocele | 2 |
Hyperplasia | 1 2 2 1 1 1 1 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 1 1 1 1 1 1 1 1 1|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Inflammation | 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | |
Hemorrhage | 3 |
Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 6| 5| 4| 3| 3| 3| 3| 3| 9| 2| 3| 3| 2|
| 0| 1| 0| 2| 1| 0| 0| 3| 2| 2| 2| 2| 5| 6| 3| 1| 0| 1| 0| 2| 4| 9| 2| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 2 |
Inflammation | 2 |
Nephropathy | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Pigmentation | 1 |
Pelvis, Inflammation | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
Transitional Epithelium, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 6| 0| 3| 3| 1| 3| |
| 0| 5| 0| 1| 0| 0| 0| 1| 5| 0| 1| 2| 1| 2| 1| 2| 4| 0| 1| 0| 1| 1| 0| 3| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X X | 8 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X X X| 47 |
Clear Cell Focus | X | 2 |
Eosinophilic Focus | X X X X | 9 |
Fatty Change | | 1 4.0|
Hemorrhage | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | X X X X X| 9 |
Inflammation | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1| 43 1.0|
Mixed Cell Focus | X X X X X X| 8 |
Necrosis | 1 2 | 3 2.3|
Vacuolization Cytoplasmic | 1 1 2 1 1 | 7 1.1|
Bile Duct, Hyperplasia | 1 1| 5 1.4|
Centrilobular, Degeneration | 1 | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + +| 7 |
Fat, Necrosis | 3 3 3 3| 6 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 1 1 1 1 | 10 1.0|
Inflammation | 1 1 | 5 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Cytoplasmic Alteration | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 2 1.0|
Inflammation | 3 | 1 3.0|
Ulcer | 3 | 3 1.7|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 6| 0| 3| 3| 1| 3| |
| 0| 5| 0| 1| 0| 0| 0| 1| 5| 0| 1| 2| 1| 2| 1| 2| 4| 0| 1| 0| 1| 1| 0| 3| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 30 1.0|
Inflammation | 1 1 | 5 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 2 2 1 1 1 2 1 1 2 1 1 1 2 1 2 1 2 1 | 27 1.3|
Degeneration, Cystic | 1 | 3 1.3|
Hyperplasia | 1 3 1 1 1 1 1 1 | 14 1.2|
Hypertrophy | 2 3 | 4 1.8|
Vacuolization Cytoplasmic | 1 | 3 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 4 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + + + + + M + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 2 2 2 2 1 2 2 2 | 19 2.1|
Cyst | 2 1 1 | 4 1.3|
Pars Distalis, Hyperplasia | 2 2 3 2 3 3 1 4 2 2 2| 23 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 3.0|
C-Cell, Hyperplasia | 1 3 4 1 1 1 1 1 1 1 2 1 4 1 1 3 1| 35 1.4|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia | 2 2 2 | 6 1.7|
Inflammation | 1 2 4 1 3 1 1 2 | 16 1.4|
Duct, Cyst | 3 | 3 2.3|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 3 | 2 3.5|
Cyst | 3 | 3 3.3|
Inflammation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 6| 0| 3| 3| 1| 3| |
| 0| 5| 0| 1| 0| 0| 0| 1| 5| 0| 1| 2| 1| 2| 1| 2| 4| 0| 1| 0| 1| 1| 0| 3| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hydrometra | | 2 3.0|
Cervix, Inflammation | 4 | 1 4.0|
Endometrium, Hyperplasia, Cystic | 1 2 | 3 1.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 3 2 3 | 9 2.6|
Myelofibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + | 27 |
Mediastinal, Pigmentation | 1 1 1 1 2 1 1 2 1 1 1 1 1 2 1 | 26 1.2|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
Ectasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 | 3 3.3|
Pigmentation | 1 1 1 1 1 2 2 2 2 2 2 1 1 1 | 25 1.6|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + M + + + + +| 46 |
Atrophy | 3 4 4 4 3 3 3 3 3 3 3 3 3 3 4 3 2 3 4 4 4 3 3 3| 46 3.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 2 2 | 2 2.0|
Galactocele | | 1 2.0|
Hyperplasia | 2 1 1 1 1 1 | 14 1.2|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteopetrosis | 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 2 1.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 6| 0| 3| 3| 1| 3| |
| 0| 5| 0| 1| 0| 0| 0| 1| 5| 0| 1| 2| 1| 2| 1| 2| 4| 0| 1| 0| 1| 1| 0| 3| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation | 1 1 1 1 1 1 1 1 1 1 1 | 23 1.0|
Pigmentation | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 40 1.0|
Alveolar Epithelium, Hyperplasia | 1 1 2 1 1 1 1 1 | 8 1.1|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X | 2 |
Inflammation | 2 | 3 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 3 |
Cataract | 3 | 1 3.0|
Hemorrhage | | 1 3.0|
Retina, Degeneration | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydronephrosis | | 1 2.0|
Inflammation | | 1 2.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 39 1.0|
Pigmentation | 1 1 1 2 | 5 1.2|
Pelvis, Inflammation | 1 | 2 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calculus Micro Observation Only | | 1 |
Transitional Epithelium, Hyperplasia | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 4| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 8| 3| 6| 3| 3| 3| 9| 5| 3| 3|
| 2| 1| 0| 2| 0| 1| 1| 0| 2| 0| 9| 2| 2| 1| 2| 0| 0| 6| 1| 2| 2| 0| 1| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
30 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | |
Eosinophilic Focus | X X X X X |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X X |
Inflammation | 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1|
Mixed Cell Focus | X X X X X X X X X|
Vacuolization Cytoplasmic | 1 1 2 1|
Bile Duct, Hyperplasia | 2 1 1 1 1 1 1 1 |
Centrilobular, Degeneration | 2 2 2 3 |
Centrilobular, Hypertrophy | 2 |
__________________________________________________________________________|
Mesentery | + + + + |
Inflammation | 3 |
Artery, Inflammation | 3 |
Fat, Necrosis | 3 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 3 1 1 1 |
Hyperplasia | |
Inflammation | 1 1|
Thrombosis | 4 |
Artery, Inflammation | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Cytoplasmic Alteration | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
Inflammation | |
Ulcer | 2 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 4| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 8| 3| 6| 3| 3| 3| 9| 5| 3| 3|
| 2| 1| 0| 2| 0| 1| 1| 0| 2| 0| 9| 2| 2| 1| 2| 0| 0| 6| 1| 2| 2| 0| 1| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
30 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 |
Inflammation | 1 1 |
Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 2 1 1 1 1 1 1 2 |
Degeneration, Cystic | 2 |
Hyperplasia | 1 1 1 1 1 |
Hypertrophy | 2 1 |
Vacuolization Cytoplasmic | 1 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + M +|
Hyperplasia | 1 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + I + + + + + + + + + +|
Angiectasis | 2 2 1 1 2 2 2 2 4|
Cyst | 2 2 1 2 |
Pars Distalis, Hyperplasia | 2 2 1 3 1 2 1 3 1 2 2 4 2 3 2 4|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
C-Cell, Hyperplasia | 1 1 2 1 2 1 1 1 1 1 1 1 1 1 1 1 3 2 1 1|
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 |
Inflammation | 1 2 1 1 1 1 1|
Duct, Cyst | 4 3 2 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Cyst | 3 3 2 4|
Infiltration Cellular, Histiocyte | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
Endometrium, Hyperplasia, Cystic | 1 2 1 3|
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 4| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 8| 3| 6| 3| 3| 3| 9| 5| 3| 3|
| 2| 1| 0| 2| 0| 1| 1| 0| 2| 0| 9| 2| 2| 1| 2| 0| 0| 6| 1| 2| 2| 0| 1| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
30 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia | |
Inflammation | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | 3 1 2 2 2 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + +|
Mediastinal, Hyperplasia, Plasma Cell| 3 |
Mediastinal, Pigmentation | 1 2 1 2 2 2 2 1|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 1 1 1 1 |
Hyperplasia, Plasma Cell | 3 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 |
Pigmentation | 1 1 2 2 1 2 1 2 1|
Capsule, Fibrosis | 1 |
Lymphoid Follicle, Atrophy | |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 4 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 3 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 1 1 1 1 1 3 4|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Inflammation | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation | 1 2 1 1 1 1 1 1 1 1 1 |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 4| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 8| 3| 6| 3| 3| 3| 9| 5| 3| 3|
| 2| 1| 0| 2| 0| 1| 1| 0| 2| 0| 9| 2| 2| 1| 2| 0| 0| 6| 1| 2| 2| 0| 1| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
30 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia | 2 |
Bronchiole, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 3 2 |
Retina, Degeneration | 4 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glomerulosclerosis | |
Inflammation | 1 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Pigmentation | 1 1 |
Vacuolization Cytoplasmic | |
Pelvis, Inflammation | 1 |
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Fibrosis | 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
__________________________________________________________________________________________________________________________________
| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| |
DAY ON TEST | 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 5| 6| 3| 3| 1| 3| 3| |
| 3| 9| 1| 1| 1| 1| 2| 2| 1| 0| 0| 1| 2| 2| 0| 2| 0| 1| 2| 6| 0| 1| 6| 2| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
30 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 1 1.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X X X| 48 |
Clear Cell Focus | X X X X X | 5 |
Eosinophilic Focus | X X X X X| 10 |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hepatodiaphragmatic Nodule | X X X X X X X X| 11 |
Inflammation | 1 1 1 1 1 2 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 2| 44 1.1|
Mixed Cell Focus | X X X X X X X X X X| 19 |
Vacuolization Cytoplasmic | 1 1 1 1 2 1 1| 11 1.2|
Bile Duct, Hyperplasia | 1 1 1 1 | 12 1.1|
Centrilobular, Degeneration | 1 | 5 2.0|
Centrilobular, Hypertrophy | 1 | 2 1.5|
__________________________________________________________________________|____________|
Mesentery | + + + + | 8 |
Inflammation | 2 | 2 2.5|
Artery, Inflammation | | 1 3.0|
Fat, Necrosis | 3 2 3 | 6 2.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 1 | 8 1.3|
Hyperplasia | 1 | 1 1.0|
Inflammation | | 2 1.0|
Thrombosis | | 1 4.0|
Artery, Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 1.0|
Cytoplasmic Alteration | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
__________________________________________________________________________________________________________________________________
| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| |
DAY ON TEST | 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 5| 6| 3| 3| 1| 3| 3| |
| 3| 9| 1| 1| 1| 1| 2| 2| 1| 0| 0| 1| 2| 2| 0| 2| 0| 1| 2| 6| 0| 1| 6| 2| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
30 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Erosion | | 1 1.0|
Inflammation | 2 | 1 2.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 1 2 2 1 2 1 | 23 1.1|
Inflammation | 1 1 | 4 1.0|
Thrombosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 1 2 1 1 1 1 1 1 2 1| 21 1.3|
Degeneration, Cystic | | 1 2.0|
Hyperplasia | 1 1 1 1 1 1 | 11 1.0|
Hypertrophy | 1 1 | 4 1.3|
Vacuolization Cytoplasmic | 1 3 2 1 | 6 1.8|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 2 1 1 | 8 1.1|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 1 2 1 2 3 2 2 1 | 17 1.9|
Cyst | | 4 1.8|
Pars Distalis, Hyperplasia | 1 4 1 3 1 1 3 1 2 3 1 1 | 28 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 1 1.0|
C-Cell, Hyperplasia | 1 4 2 1 2 2 1 1 2 1 3 1 1 1 1 1 1 1| 38 1.4|
Follicular Cell, Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 4 1| 6 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
__________________________________________________________________________________________________________________________________
| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| |
DAY ON TEST | 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 5| 6| 3| 3| 1| 3| 3| |
| 3| 9| 1| 1| 1| 1| 2| 2| 1| 0| 0| 1| 2| 2| 0| 2| 0| 1| 2| 6| 0| 1| 6| 2| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
30 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation | 1 1 2 2 1 1 4 1 1 1 | 17 1.4|
Duct, Cyst | 2 | 5 2.6|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 2 2.5|
Cyst | 1 3 4 | 7 2.9|
Infiltration Cellular, Histiocyte | 1 | 2 2.5|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 2.0|
Endometrium, Hyperplasia, Cystic | 2 1 2 | 7 1.7|
__________________________________________________________________________|____________|
Vagina | + | 2 |
Hyperplasia | 4 | 1 4.0|
Inflammation | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 1 3.0|
Hyperplasia | 3 3 3 3 3 3 | 12 2.6|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + +| 23 |
Mediastinal, Hyperplasia, Plasma Cell| | 1 3.0|
Mediastinal, Pigmentation | 1 1 1 2 2 2 1 1 2 1 2| 19 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 1 1 1 1 | 8 1.0|
Hyperplasia, Plasma Cell | 2 3 | 4 2.8|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 1 3.0|
Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 4 2 | 4 2.8|
Pigmentation | 1 2 2 2 1 1 2 2 1 1 2 1 1 1 1 1 2| 26 1.4|
Capsule, Fibrosis | | 1 1.0|
Lymphoid Follicle, Atrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 |
Atrophy | 2 2 3 3 3 3 4 3 3 3 3 2 2 3 2 2 3 4 4 3 3 3 3 3| 46 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 1 1 1 1 2 1 1| 19 1.4|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Inflammation | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
__________________________________________________________________________________________________________________________________
| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| |
DAY ON TEST | 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 5| 6| 3| 3| 1| 3| 3| |
| 3| 9| 1| 1| 1| 1| 2| 2| 1| 0| 0| 1| 2| 2| 0| 2| 0| 1| 2| 6| 0| 1| 6| 2| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
30 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteopetrosis | 3 | 2 2.5|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
Inflammation | 1 1 1 1 1 1 1 1 1 1| 21 1.0|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 40 1.0|
Thrombosis | | 1 4.0|
Alveolar Epithelium, Hyperplasia | 2 2 2 1 1 1 | 7 1.6|
Bronchiole, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 3 | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Cataract | | 2 2.5|
Retina, Degeneration | | 2 3.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Glomerulosclerosis | 1 | 1 1.0|
Inflammation | | 1 1.0|
Nephropathy | 1 2 2 1 1 1 1 1 1 1 1 1 1 1 2 1 2 2 1 1 1| 43 1.1|
Pigmentation | | 2 1.0|
Vacuolization Cytoplasmic | 2 | 1 2.0|
Pelvis, Inflammation | | 1 1.0|
Renal Tubule, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Serosa, Fibrosis | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
_____________________________________________________________________________________________________________________
| 5| 5| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 3| 6| 3| 3| 6| 3| 3| 3| 3| 3| 2| 3| 7| 3| 3| 3| 0| 0| 3| 3| 3| 3| 2| 7|
| 6| 6| 8| 0| 1| 2| 0| 0| 2| 2| 0| 5| 1| 6| 2| 0| 1| 1| 3| 1| 1| 0| 1| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X |
Clear Cell Focus | X |
Eosinophilic Focus | X X X X X X X |
Hepatodiaphragmatic Nodule | X X X X X X X X|
Inflammation | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 |
Mixed Cell Focus | X |
Necrosis | 2 |
Pigmentation | |
Vacuolization Cytoplasmic | 2 1 4|
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 |
Centrilobular, Degeneration | 2 3 4 3 2|
Centrilobular, Hypertrophy | 1 1 1 1 1 1 2 2 1 1 2 1 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 1 1 1 |
Cytoplasmic Alteration | |
Inflammation | 1 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 |
Cytoplasmic Alteration | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperplasia | 3 |
Inflammation | |
Ulcer | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Ulcer | 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
_____________________________________________________________________________________________________________________
| 5| 5| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 3| 6| 3| 3| 6| 3| 3| 3| 3| 3| 2| 3| 7| 3| 3| 3| 0| 0| 3| 3| 3| 3| 2| 7|
| 6| 6| 8| 0| 1| 2| 0| 0| 2| 2| 0| 5| 1| 6| 2| 0| 1| 1| 3| 1| 1| 0| 1| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1|
Thrombosis | 1 |
Valve, Inflammation | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Degeneration, Cystic | 1 |
Hyperplasia | 1 1 1 1 1 1 1 2 1 1 |
Hypertrophy | 1|
Inflammation | |
Necrosis | |
Vacuolization Cytoplasmic | 1 1 3 1 3|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Hyperplasia | 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M + + M + M + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 3 2 1 2 2 2 1 1 2 1 2 |
Pars Distalis, Hyperplasia | 3 1 3 1 3 4 1 1 1 1 1 4 1|
Pars Intermedia, Hyperplasia | |
Pars Nervosa, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 4 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation | 1 1 1 1 1 1 1 1 2 1 |
Duct, Cyst | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | 1 1|
Infiltration Cellular, Histiocyte | 2 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Hydrometra | 3 4 |
Cervix, Cyst, Squamous | 3 |
Cervix, Hydrometra | |
Cervix, Hyperplasia, Squamous | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
_____________________________________________________________________________________________________________________
| 5| 5| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 3| 6| 3| 3| 6| 3| 3| 3| 3| 3| 2| 3| 7| 3| 3| 3| 0| 0| 3| 3| 3| 3| 2| 7|
| 6| 6| 8| 0| 1| 2| 0| 0| 2| 2| 0| 5| 1| 6| 2| 0| 1| 1| 3| 1| 1| 0| 1| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cervix, Inflammation | 3 |
Endometrium, Hyperplasia, Cystic | 1 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 2 |
Inflammation, Granulomatous | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + |
Mediastinal, Pigmentation | 1 1 1 1 2 1 2 1 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 1 1 1 |
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
Fibrosis | |
Hematopoietic Cell Proliferation | 1 3 1 |
Infarct | |
Pigmentation | 2 1 1 1 1 1 1 1 1 1 2 1 1 1 |
Lymphoid Follicle, Atrophy | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 4 3 3 2 4 3 3 3 3 3 4 3 4 4 4 4 4 3 3 4 3 4 4|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Galactocele | 4 4 2 2|
Hyperplasia | 1 1 1 2 1 1 1 1|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 3 4 3 2 2 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
__________________________________________________________________________|
Peripheral Nerve | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
_____________________________________________________________________________________________________________________
| 5| 5| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 3| 6| 3| 3| 6| 3| 3| 3| 3| 3| 2| 3| 7| 3| 3| 3| 0| 0| 3| 3| 3| 3| 2| 7|
| 6| 6| 8| 0| 1| 2| 0| 0| 2| 2| 0| 5| 1| 6| 2| 0| 1| 1| 3| 1| 1| 0| 1| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation | 1 1 1 1 1 1 1 1 1 1 1 |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Thrombosis | 1 |
Alveolar Epithelium, Hyperplasia | 2 1 1 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Inflammation | 1 2 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 2 |
Inflammation | 2 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1|
Pigmentation | 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 8| 3| 3| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 6| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 2| 7| 2| 1| 0| 4| 1| 0| 5| 2| 0| 0| 1| 1| 7| 8| 1| 0| 2| 1| 0| 2| 0| 0| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
100 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 1 1.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X| 43 |
Clear Cell Focus | | 1 |
Eosinophilic Focus | X X X X X X X| 14 |
Hepatodiaphragmatic Nodule | X X X X | 12 |
Inflammation | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1| 39 1.1|
Mixed Cell Focus | X X X X X X | 7 |
Necrosis | | 1 2.0|
Pigmentation | 1 | 1 1.0|
Vacuolization Cytoplasmic | 1 1 3 1 2 1 | 9 1.8|
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1| 21 1.0|
Centrilobular, Degeneration | 1 1 3 2 1 | 10 2.2|
Centrilobular, Hypertrophy | 2 1 2 1 1 1 1 1 2 2 1 1 | 24 1.3|
__________________________________________________________________________|____________|
Mesentery | + + + | 4 |
Fat, Necrosis | 3 3 3 | 4 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 1 | 8 1.1|
Cytoplasmic Alteration | 1 | 1 1.0|
Inflammation | 1 1 1 1 | 7 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 2 1.0|
Cytoplasmic Alteration | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 | 1 3.0|
Hyperplasia | | 1 3.0|
Inflammation | 2 | 1 2.0|
Ulcer | 2 | 2 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 8| 3| 3| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 6| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 2| 7| 2| 1| 0| 4| 1| 0| 5| 2| 0| 0| 1| 1| 7| 8| 1| 0| 2| 1| 0| 2| 0| 0| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
100 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1| 23 1.0|
Thrombosis | | 1 1.0|
Valve, Inflammation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 1 1 1 1 1 1 1 1 1 1 1| 26 1.0|
Degeneration, Cystic | 1 | 2 1.0|
Hyperplasia | 1 1 1 1 1 1 1 1 1| 19 1.1|
Hypertrophy | 1 1 1 1 | 5 1.0|
Inflammation | 1 | 1 1.0|
Necrosis | 2 | 1 2.0|
Vacuolization Cytoplasmic | | 5 1.8|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 4 | 2 4.0|
Hyperplasia | 4 4 | 3 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + M + + + + M +| 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 3 2 1 2 1 2 3 2 2 | 23 1.8|
Pars Distalis, Hyperplasia | 3 2 1 4 1 2 2 2 2 3| 23 2.0|
Pars Intermedia, Hyperplasia | 1 | 1 1.0|
Pars Nervosa, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1| 34 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 3 4 1 4 | 6 3.0|
Inflammation | 3 2 1 2 1 1 1 1 1 3 1| 21 1.3|
Duct, Cyst | 1 4 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 8| 3| 3| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 6| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 2| 7| 2| 1| 0| 4| 1| 0| 5| 2| 0| 0| 1| 1| 7| 8| 1| 0| 2| 1| 0| 2| 0| 0| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
100 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 1 3.0|
Cyst | 2 | 3 1.3|
Infiltration Cellular, Histiocyte | 2 | 3 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 4.0|
Hydrometra | 3 4 | 4 3.5|
Cervix, Cyst, Squamous | | 1 3.0|
Cervix, Hydrometra | 3 | 1 3.0|
Cervix, Hyperplasia, Squamous | 2 | 1 2.0|
Cervix, Inflammation | | 1 3.0|
Endometrium, Hyperplasia, Cystic | 2 2 1 2 | 7 1.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 3 4 2 1 | 8 2.6|
Inflammation, Granulomatous | 1 | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + +| 28 |
Mediastinal, Pigmentation | 1 1 1 2 1 1 1 2 2 1 1 1 1 1 1 1 1| 26 1.2|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Ectasia | 2 1 | 5 1.2|
Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | X | 1 |
Fibrosis | 1 1 | 2 1.0|
Hematopoietic Cell Proliferation | 1 1 1 1 | 7 1.3|
Infarct | 4 | 1 4.0|
Pigmentation | 1 1 2 1 1 1 2 1 2 1 1 1 1 1| 28 1.2|
Lymphoid Follicle, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 4 4 2 3 3 4 4 3 2 4 3 3 3 3 3 3 4 3 3 3 3 3| 47 3.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 1 | 1 1.0|
Galactocele | 3 2 | 6 2.8|
Hyperplasia | 1 1 1 1 1 1 1 1 1 2 1 1 | 20 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 8| 3| 3| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 6| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 2| 7| 2| 1| 0| 4| 1| 0| 5| 2| 0| 0| 1| 1| 7| 8| 1| 0| 2| 1| 0| 2| 0| 0| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
100 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteopetrosis | 3 | 6 2.8|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 1.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 | 1 1.0|
Inflammation | 1 1 1 1 2 1 1 1 1 1 1 1| 23 1.0|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 42 1.0|
Thrombosis | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 1 2 1 4 1| 9 1.9|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 |
Inflammation | | 4 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | | 1 2.0|
Inflammation | | 1 2.0|
Nephropathy | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 42 1.0|
Pigmentation | 1 1 1 1 1 | 9 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 5| 6| 7| 4| 7| 7| 7| 7| 3| 7| 7| 7| 5| 7| 5| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 6| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 3| 1| 3| 8| 3| 3| 5| 3| 3| 3|
| 0| 0| 0| 5| 1| 1| 1| 4| 2| 2| 2| 0| 7| 1| 2| 0| 1| 2| 4| 0| 1| 9| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X |
Eosinophilic Focus | X X|
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X X X X X X X|
Inflammation | 1 1 1 1 1 1 1 1 2 1 1 1 1 2 1|
Mixed Cell Focus | X X X|
Necrosis | 1 1 |
Vacuolization Cytoplasmic | 1 1 2 2 1 1 1 |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Centrilobular, Degeneration | 2 2 1 |
Centrilobular, Hypertrophy | 2 2 2 2 1 1 1 2 1 1 2 2 2 1 2 1 2 2 2 2|
__________________________________________________________________________|
Mesentery | + + +|
Artery, Inflammation | 2 |
Fat, Necrosis | 3 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 1 |
Cytoplasmic Alteration | 1 |
Hyperplasia | |
Inflammation | 1 |
Metaplasia, Hepatocyte | 1 |
Artery, Inflammation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
Mineralization | |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | + + + |
Inflammation | 4 |
Peridontal Tissue, Inflammation | 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 5| 6| 7| 4| 7| 7| 7| 7| 3| 7| 7| 7| 5| 7| 5| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 6| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 3| 1| 3| 8| 3| 3| 5| 3| 3| 3|
| 0| 0| 0| 5| 1| 1| 1| 4| 2| 2| 2| 0| 7| 1| 2| 0| 1| 2| 4| 0| 1| 9| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Inflammation | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 1 1 1 1 1 1 1 1 1 1 2 1 |
Inflammation | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 |
Angiectasis | 1 1 1 1 1 1 1 1 1 1 2 1|
Hyperplasia | 1 1 1 1 1 1 1 1 1|
Hypertrophy | 2 1 |
Necrosis | 1 2 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M M + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 1 2 4 2 1 2 1 2|
Cyst | 1 |
Pars Distalis, Hyperplasia | 3 3 3 1 3 2 3 2 1 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 4 2 1 3 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation | 1 1 1 1 1 1 1|
Duct, Cyst | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Infiltration Cellular, Histiocyte | 1 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Dilatation | |
Hyperplasia | |
Inflammation | 1 |
Cervix, Cyst, Squamous | |
Cervix, Inflammation | 4 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 5| 6| 7| 4| 7| 7| 7| 7| 3| 7| 7| 7| 5| 7| 5| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 6| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 3| 1| 3| 8| 3| 3| 5| 3| 3| 3|
| 0| 0| 0| 5| 1| 1| 1| 4| 2| 2| 2| 0| 7| 1| 2| 0| 1| 2| 4| 0| 1| 9| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Endometrium, Adenomyosis | 2 |
Endometrium, Hyperplasia, Cystic | 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 3 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + +|
Mediastinal, Congestion | |
Mediastinal, Ectasia | |
Mediastinal, Pigmentation | 1 1 2 1 2 1 1 1 2 1 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 1 1 |
Hyperplasia, Plasma Cell | 4 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 |
Hematopoietic Cell Proliferation | 4 1 |
Pigmentation | 1 2 2 1 2 2 1 1 1 1 3 2 2 1 2 2 1|
Lymphoid Follicle, Atrophy | 3 3 3 |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 3 3 3 3 4 4 3 3 3 2 3 4 4 4 3 3 3 3 3 3 2 4|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Galactocele | |
Hyperplasia | 1 1 1 1 1|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + M + + + + + + + + + + +|
Inflammation | 3 |
Ulcer | 2 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 3 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 5| 6| 7| 4| 7| 7| 7| 7| 3| 7| 7| 7| 5| 7| 5| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 6| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 3| 1| 3| 8| 3| 3| 5| 3| 3| 3|
| 0| 0| 0| 5| 1| 1| 1| 4| 2| 2| 2| 0| 7| 1| 2| 0| 1| 2| 4| 0| 1| 9| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Necrosis | |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 1 2 1 |
Mediastinum, Thrombosis | |
Serosa, Inflammation | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Nasolacrimal Duct, Inflammation | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Atrophy | |
Cataract | 3 |
Hemorrhage | |
Cornea, Edema | |
Retina, Degeneration | 2 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Inflammation | 1 |
Nephropathy | 1 2 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Pigmentation | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X |
Transitional Epithelium, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 3| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 0| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| |
| 3| 2| 1| 9| 0| 7| 2| 2| 0| 4| 1| 1| 1| 2| 1| 2| 9| 1| 0| 1| 1| 2| 1| 7| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
300 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 2 1.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X| 36 |
Clear Cell Focus | X | 2 |
Eosinophilic Focus | X X X X X | 7 |
Hematopoietic Cell Proliferation | | 1 1.0|
Hepatodiaphragmatic Nodule | X X X X X X X | 14 |
Inflammation | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1| 30 1.1|
Mixed Cell Focus | X X X X X X | 9 |
Necrosis | 1 2 | 4 1.3|
Vacuolization Cytoplasmic | 1 1 | 9 1.2|
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 32 1.0|
Centrilobular, Degeneration | 3 1 1 2 | 7 1.7|
Centrilobular, Hypertrophy | 1 1 1 2 2 2 2 2 2 2 2 2 2 1 2 2 1 2| 38 1.7|
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Artery, Inflammation | | 1 2.0|
Fat, Necrosis | 3 | 3 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 1 1 1 | 8 1.0|
Cytoplasmic Alteration | | 1 1.0|
Hyperplasia | 3 | 1 3.0|
Inflammation | 1 1 | 3 1.0|
Metaplasia, Hepatocyte | | 1 1.0|
Artery, Inflammation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 1 1 | 3 1.0|
Mineralization | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 3| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 0| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| |
| 3| 2| 1| 9| 0| 7| 2| 2| 0| 4| 1| 1| 1| 2| 1| 2| 9| 1| 0| 1| 1| 2| 1| 7| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
300 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | + | 4 |
Inflammation | | 1 4.0|
Peridontal Tissue, Inflammation | 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 | 27 1.1|
Inflammation | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | | 1 2.0|
Angiectasis | 1 1 1 1 1 1 1 1 1 1 2 1 1 1| 26 1.1|
Hyperplasia | 1 1 1 1 1 1 1 1 2| 18 1.1|
Hypertrophy | 1 | 3 1.3|
Necrosis | | 2 1.5|
Vacuolization Cytoplasmic | 1| 1 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + + + + + M M + + + + + + M + +| 43 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 1 1 3 2 3 2 2 2 2 2 | 21 1.9|
Cyst | 3 2 | 3 2.0|
Pars Distalis, Hyperplasia | 2 2 2 1 4 1 3 2 3 3 2 1 2| 24 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 4 1 1 1 1 1 2 1 1 1 1 1 1 1 1| 23 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 3 3 | 3 2.7|
Inflammation | 1 1 1 1 1 1 1 1 1 1 1 | 18 1.0|
Duct, Cyst | 2 1| 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 3| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 0| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| |
| 3| 2| 1| 9| 0| 7| 2| 2| 0| 4| 1| 1| 1| 2| 1| 2| 9| 1| 0| 1| 1| 2| 1| 7| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
300 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 1 | 2 2.5|
Infiltration Cellular, Histiocyte | | 1 1.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 4.0|
Dilatation | 4 | 1 4.0|
Hyperplasia | 2 | 1 2.0|
Inflammation | | 1 1.0|
Cervix, Cyst, Squamous | 2 | 1 2.0|
Cervix, Inflammation | 4 | 2 4.0|
Endometrium, Adenomyosis | | 1 2.0|
Endometrium, Hyperplasia, Cystic | 1 2 2 1 | 6 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 3 2 3 | 12 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + +| 28 |
Mediastinal, Congestion | 4 | 1 4.0|
Mediastinal, Ectasia | 2 | 1 2.0|
Mediastinal, Pigmentation | 1 1 1 2 2 2 1 1 1 2 1 1 2| 24 1.4|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 1 1 1 | 5 1.0|
Hyperplasia, Plasma Cell | 3 3 4 | 5 3.6|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 1.0|
Hematopoietic Cell Proliferation | | 2 2.5|
Pigmentation | 1 1 2 1 2 2 1 1 1 2 2 1 2 2 1| 32 1.5|
Lymphoid Follicle, Atrophy | | 3 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 |
Atrophy | 3 3 2 4 4 4 4 4 3 4 3 3 3 3 4 4 3 3 4 4 4 3 4 3| 48 3.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 1 2.0|
Galactocele | 4 | 1 4.0|
Hyperplasia | 1 1 1 3 1 | 10 1.2|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 3| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 0| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| |
| 3| 2| 1| 9| 0| 7| 2| 2| 0| 4| 1| 1| 1| 2| 1| 2| 9| 1| 0| 1| 1| 2| 1| 7| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
300 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Ulcer | | 2 1.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteopetrosis | 3 3 | 4 3.3|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 2.0|
Necrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 | 1 2.0|
Hemorrhage | 1 | 1 1.0|
Inflammation | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 2 1| 31 1.1|
Necrosis | 2 2 | 2 2.0|
Pigmentation | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 35 1.0|
Thrombosis | 3 | 1 3.0|
Alveolar Epithelium, Hyperplasia | 3 1 1 3 3 1 | 9 1.8|
Mediastinum, Thrombosis | 4 | 1 4.0|
Serosa, Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 1 2 1 | 4 1.3|
Nasolacrimal Duct, Inflammation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 4 |
Atrophy | 3 | 1 3.0|
Cataract | 3 3 | 3 3.0|
Hemorrhage | 2 | 1 2.0|
Cornea, Edema | 3 | 1 3.0|
Retina, Degeneration | 3 4 | 3 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 3| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 0| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| |
| 3| 2| 1| 9| 0| 7| 2| 2| 0| 4| 1| 1| 1| 2| 1| 2| 9| 1| 0| 1| 1| 2| 1| 7| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
300 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Hydronephrosis | 2 | 1 2.0|
Inflammation | 1 | 2 1.0|
Nephropathy | 1 1 2 2 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 42 1.2|
Pigmentation | 1 2 1 1 1 2 1 | 9 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calculus Gross Observation | | 1 |
Transitional Epithelium, Hyperplasia | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
_____________________________________________________________________________________________________________________
| 6| 3| 7| 6| 6| 3| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 6| 3|
DAY ON TEST | 8| 6| 3| 3| 8| 1| 2| 2| 2| 3| 3| 1| 4| 3| 2| 3| 9| 1| 1| 2| 3| 4| 1| 4| 6|
| 2| 8| 0| 3| 2| 2| 9| 9| 9| 0| 0| 7| 0| 0| 9| 0| 7| 2| 8| 9| 0| 2| 8| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X |
Degeneration, Cystic | 1 1 1 1 |
Eosinophilic Focus | X X |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X |
Inflammation | 1 1 1 1 1 1 1 1 1 |
Mixed Cell Focus | X X X X |
Necrosis | 2 1 |
Pigmentation | 2 |
Vacuolization Cytoplasmic | 1 1 1 1 1 |
Bile Duct, Hyperplasia | 2 1 2 3 3 1 1 1 1 1 1 3 1 2 2 1 2 2 2 2 1 1 2 |
Centrilobular, Degeneration | 2 3 1 1 1 2 3 2 1 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + |
Necrosis | 2 |
Fat, Inflammation | |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 1 1 1 1 1 1 |
Cytoplasmic Alteration | 1 |
Hyperplasia | 1 1 |
Inflammation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Cytoplasmic Alteration | |
Duct, Hyperplasia | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Hyperplasia | 3 3 |
Inflammation | 3 |
Ulcer | 3 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
_____________________________________________________________________________________________________________________
| 6| 3| 7| 6| 6| 3| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 6| 3|
DAY ON TEST | 8| 6| 3| 3| 8| 1| 2| 2| 2| 3| 3| 1| 4| 3| 2| 3| 9| 1| 1| 2| 3| 4| 1| 4| 6|
| 2| 8| 0| 3| 2| 2| 9| 9| 9| 0| 0| 7| 0| 0| 9| 0| 7| 2| 8| 9| 0| 2| 8| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | 1 |
Hyperplasia | 2 |
Ulcer | 1 |
__________________________________________________________________________|
Tooth | |
Peridontal Tissue, Inflammation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 1 2 1 1 1 1 1 2 1 1 2 1 1 1 |
Inflammation | 1 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 |
Degeneration, Cystic | 1|
Hyperplasia | 1 1 1 2 1 2 1|
Hypertrophy | 1 3 |
Necrosis | |
Vacuolization Cytoplasmic | 2 2 2 3 4 3|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 4 4 3 |
Cyst | 1 |
Hemorrhage | |
Pars Distalis, Hyperplasia | 3 3 1 1 2 3 |
Pars Distalis, Pseudocyst | 2 2 2 |
Pars Intermedia, Cyst | |
Pars Intermedia, Pseudocyst | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
C-Cell, Hyperplasia | 2 1 1 1 1 1 1 2 1 1 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
_____________________________________________________________________________________________________________________
| 6| 3| 7| 6| 6| 3| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 6| 3|
DAY ON TEST | 8| 6| 3| 3| 8| 1| 2| 2| 2| 3| 3| 1| 4| 3| 2| 3| 9| 1| 1| 2| 3| 4| 1| 4| 6|
| 2| 8| 0| 3| 2| 2| 9| 9| 9| 0| 0| 7| 0| 0| 9| 0| 7| 2| 8| 9| 0| 2| 8| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia | |
Inflammation | 1 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 2 1 1 2 1 1 2 1 2 2 2 1 2 2 2 2 2 3 2 1|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 3 1 3 1 1 3 1 3 3 2 1 1 1 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Inflammation | 1|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 3|
Hyperplasia | |
Artery, Inflammation | 2 |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 3 2 2 4 4 3 2|
Myelofibrosis | 4 |
Necrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Mediastinal, Necrosis | 4 |
Mediastinal, Pigmentation | 1 1 2 |
Renal, Hyperplasia, Plasma Cell | |
Renal, Necrosis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hyperplasia, Plasma Cell | 4 4 |
Necrosis | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Necrosis | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X |
Fibrosis | 4 |
Hematopoietic Cell Proliferation | 2 1 |
Hyperplasia, Stromal | |
Necrosis | |
Pigmentation | 2|
Lymphoid Follicle, Atrophy | |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + + + + + + + + + +|
Atrophy | 4 2 4 4 4 2 4 4 4 2 4 4 3 3 4 2 3 3 4 3 4 4|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
_____________________________________________________________________________________________________________________
| 6| 3| 7| 6| 6| 3| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 6| 3|
DAY ON TEST | 8| 6| 3| 3| 8| 1| 2| 2| 2| 3| 3| 1| 4| 3| 2| 3| 9| 1| 1| 2| 3| 4| 1| 4| 6|
| 2| 8| 0| 3| 2| 2| 9| 9| 9| 0| 0| 7| 0| 0| 9| 0| 7| 2| 8| 9| 0| 2| 8| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hyperplasia | 1 2 |
Inflammation | 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 2 |
Necrosis | 2 |
__________________________________________________________________________|
Spinal Cord | + |
Hemorrhage | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Hemorrhage | 2 1 |
Inflammation, Granulomatous | 2 |
Inflammation | 1 1 1 1 1 1 1 1 |
Necrosis | |
Pigmentation | 1 |
Thrombosis | 1 |
Alveolar Epithelium, Hyperplasia | 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation | 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Zymbal's Gland | +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 4 |
Nephropathy | 1 2 1 2 1 2 2 1 1 1 3 2 1 2 1 2 1 2 2 1 1 |
Pigmentation | 1 2 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
_____________________________________________________________________________________________________________________
| 6| 3| 7| 6| 6| 3| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 6| 3|
DAY ON TEST | 8| 6| 3| 3| 8| 1| 2| 2| 2| 3| 3| 1| 4| 3| 2| 3| 9| 1| 1| 2| 3| 4| 1| 4| 6|
| 2| 8| 0| 3| 2| 2| 9| 9| 9| 0| 0| 7| 0| 0| 9| 0| 7| 2| 8| 9| 0| 2| 8| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Artery, Inflammation | 2 |
Renal Tubule, Degeneration | 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 7| 3| |
DAY ON TEST | 8| 2| 2| 2| 1| 3| 2| 2| 5| 2| 3| 3| 6| 3| 4| 3| 1| 8| 2| 2| 2| 7| 1| 3| 1| |
| 2| 9| 9| 9| 3| 0| 9| 3| 4| 9| 0| 0| 9| 0| 0| 0| 1| 7| 9| 8| 9| 4| 4| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X | 30 |
Clear Cell Focus | X X X | 6 |
Degeneration, Cystic | 1 | 5 1.0|
Eosinophilic Focus | X X X X | 6 |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hepatodiaphragmatic Nodule | X X X X X | 7 |
Inflammation | 1 1 1 1 1 1 1 1 1 | 18 1.0|
Mixed Cell Focus | X X X | 7 |
Necrosis | 1 4 | 4 2.0|
Pigmentation | 1 | 2 1.5|
Vacuolization Cytoplasmic | 1 1 2 1 | 9 1.1|
Bile Duct, Hyperplasia | 3 1 1 2 2 2 2 3 2 2 2 2 2 2 1 2 1 1 1 3 3 1 1| 46 1.7|
Centrilobular, Degeneration | 2 2 2 2 3 2 2 3 2 | 18 2.0|
Centrilobular, Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | + + + +| 7 |
Necrosis | | 1 2.0|
Fat, Inflammation | 3 | 1 3.0|
Fat, Necrosis | 1 | 3 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 2 1 1 2 1 | 14 1.4|
Cytoplasmic Alteration | 1 | 2 1.0|
Hyperplasia | 4 | 3 2.0|
Inflammation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 1.0|
Cytoplasmic Alteration | 1 | 1 1.0|
Duct, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 7| 3| |
DAY ON TEST | 8| 2| 2| 2| 1| 3| 2| 2| 5| 2| 3| 3| 6| 3| 4| 3| 1| 8| 2| 2| 2| 7| 1| 3| 1| |
| 2| 9| 9| 9| 3| 0| 9| 3| 4| 9| 0| 0| 9| 0| 0| 0| 1| 7| 9| 8| 9| 4| 4| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Edema | | 1 2.0|
Hyperplasia | | 2 3.0|
Inflammation | | 1 3.0|
Ulcer | | 2 3.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 1 | 2 1.0|
Hyperplasia | | 1 2.0|
Ulcer | 1 | 2 1.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
Peridontal Tissue, Inflammation | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 2 2 1 1 1 1 2 1 2 1 1 2 2 2 2 2 1 1 1 1 | 39 1.4|
Inflammation | | 1 1.0|
Thrombosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 2 1.0|
Degeneration, Cystic | | 1 1.0|
Hyperplasia | 1 1 1 1 | 11 1.2|
Hypertrophy | 1 | 3 1.7|
Necrosis | 1 1 | 2 1.0|
Vacuolization Cytoplasmic | 1 2 | 8 2.4|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 4 4 2 1 2 3 4 1 | 14 2.1|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + M +| 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 2 1 | 7 2.6|
Cyst | 1 | 2 1.0|
Hemorrhage | 1 | 1 1.0|
Pars Distalis, Hyperplasia | 4 2 1 2 1 1 2 1 3 | 15 2.0|
Pars Distalis, Pseudocyst | 2 2 2 | 6 2.0|
Pars Intermedia, Cyst | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 7| 3| |
DAY ON TEST | 8| 2| 2| 2| 1| 3| 2| 2| 5| 2| 3| 3| 6| 3| 4| 3| 1| 8| 2| 2| 2| 7| 1| 3| 1| |
| 2| 9| 9| 9| 3| 0| 9| 3| 4| 9| 0| 0| 9| 0| 0| 0| 1| 7| 9| 8| 9| 4| 4| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Intermedia, Pseudocyst | 1 2| 3 1.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 2 | 1 2.0|
C-Cell, Hyperplasia | 4 1 1 1 1 1 1 1 | 19 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 1 1.0|
Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 2 2 2 1 2 1 2 3 1 1 2 2 1 2 1 2 2 2 1 1 2 2 2 1| 46 1.7|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 1 1 1 2 1 1 1 2 1 1 2 1 | 27 1.6|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 3 | 5 3.6|
Hyperplasia | 3 | 1 3.0|
Artery, Inflammation | | 1 2.0|
Interstitial Cell, Hyperplasia | 1 1 1 1 2 1 1 1 1 2 1 1 1 | 28 1.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 4 2 2 2 2 4 2 2 | 18 2.6|
Myelofibrosis | 2 2 1 | 4 2.3|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + +| 15 |
Mediastinal, Necrosis | | 1 4.0|
Mediastinal, Pigmentation | 2 | 4 1.5|
Renal, Hyperplasia, Plasma Cell | 3 | 1 3.0|
Renal, Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 1 1 | 3 1.3|
Hyperplasia, Plasma Cell | 4 3 | 4 3.8|
Necrosis | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 7| 3| |
DAY ON TEST | 8| 2| 2| 2| 1| 3| 2| 2| 5| 2| 3| 3| 6| 3| 4| 3| 1| 8| 2| 2| 2| 7| 1| 3| 1| |
| 2| 9| 9| 9| 3| 0| 9| 3| 4| 9| 0| 0| 9| 0| 0| 0| 1| 7| 9| 8| 9| 4| 4| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | | 1 |
Fibrosis | 1 | 2 2.5|
Hematopoietic Cell Proliferation | 2 2 | 4 1.8|
Hyperplasia, Stromal | 4 | 1 4.0|
Necrosis | 4 | 1 4.0|
Pigmentation | | 1 2.0|
Lymphoid Follicle, Atrophy | 4 4 | 2 4.0|
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + + + + + + + M + + + + + + + M| 46 |
Atrophy | 3 3 3 4 3 4 4 4 3 3 3 4 4 1 3 4 3 4 4 4 4 3 | 44 3.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + M + + + + + + + + M + + + + + + +| 47 |
Cyst | | 1 2.0|
Hyperplasia | | 2 1.5|
Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
Ulcer | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteopetrosis | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 2 2.5|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Hemorrhage | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 |
Hemorrhage | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 7| 3| |
DAY ON TEST | 8| 2| 2| 2| 1| 3| 2| 2| 5| 2| 3| 3| 6| 3| 4| 3| 1| 8| 2| 2| 2| 7| 1| 3| 1| |
| 2| 9| 9| 9| 3| 0| 9| 3| 4| 9| 0| 0| 9| 0| 0| 0| 1| 7| 9| 8| 9| 4| 4| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Granulomatous | | 1 2.0|
Inflammation | 2 1 1 | 11 1.1|
Necrosis | 3 | 1 3.0|
Pigmentation | | 1 1.0|
Thrombosis | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 1 4 4 1 3 1 2 | 9 2.1|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X X X X X | 5 |
Inflammation | 1 2 2 1 3 1 1 1 1 2 | 12 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | | 1 4.0|
Nephropathy | 1 1 1 2 1 1 2 1 2 1 1 1 2 1 2 1 1 1 2 1 2 | 42 1.4|
Pigmentation | 1 1 2 1 | 13 1.2|
Artery, Inflammation | | 1 2.0|
Renal Tubule, Degeneration | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 1| 9| 2| 2| 5| 3| 3| 0| 2| 3| 2| 3| 0| 3| 2| 3| 3| 3| 6| 2| 0| 3| 3| 0| 3|
| 7| 6| 9| 9| 9| 0| 0| 8| 9| 0| 9| 0| 1| 0| 9| 0| 0| 0| 9| 9| 9| 0| 0| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
10 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X|
Degeneration, Cystic | 1 1 1 |
Eosinophilic Focus | X X X |
Hematopoietic Cell Proliferation | |
Hemorrhage | |
Hepatodiaphragmatic Nodule | X X X |
Inflammation | 1 1 1 1 1 1 1 1 1 1|
Mixed Cell Focus | X X X X X X X|
Necrosis | 1 |
Thrombosis | |
Vacuolization Cytoplasmic | 2 1 |
Bile Duct, Hyperplasia | 3 2 1 1 2 1 1 2 3 3 2 1 2 2 1 2 1 1 1 2 1 1 1|
Centrilobular, Degeneration | 2 2 1 4 1 1 3 2 |
Centrilobular, Hypertrophy | 1 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + +|
Hemorrhage | |
Inflammation | 2 |
Fat, Inflammation | 2 |
Fat, Necrosis | 3 3 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 1 1 1 2 1 2 |
Cytoplasmic Alteration | 1 |
Hyperplasia | 1 |
Inflammation | |
Duct, Hyperplasia | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperplasia | |
Inflammation | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 1| 9| 2| 2| 5| 3| 3| 0| 2| 3| 2| 3| 0| 3| 2| 3| 3| 3| 6| 2| 0| 3| 3| 0| 3|
| 7| 6| 9| 9| 9| 0| 0| 8| 9| 0| 9| 0| 1| 0| 9| 0| 0| 0| 9| 9| 9| 0| 0| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
10 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Edema | 2 |
Erosion | |
Ulcer | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 2 1 1 1 1 2 1 1 1 1 2 2 1 2 2 1 2 1 1|
Thrombosis | 3 3 3 |
Epicardium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | |
Hyperplasia | 1 2 1 2 1 1 |
Hypertrophy | 1 1 |
Vacuolization Cytoplasmic | 1 1 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 4 1 1 |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 4 2 3|
Cyst | 2 1 1 1 1 1 |
Pars Distalis, Hyperplasia | 1 1 2 2 1 3 2 4 4|
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 3 1 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Mesothelium, Hyperplasia | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 2 1 2 1 1 2 2 2 2 2 2 1 1 1 2 1 1 1 2|
Duct, Cyst | 2|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 1| 9| 2| 2| 5| 3| 3| 0| 2| 3| 2| 3| 0| 3| 2| 3| 3| 3| 6| 2| 0| 3| 3| 0| 3|
| 7| 6| 9| 9| 9| 0| 0| 8| 9| 0| 9| 0| 1| 0| 9| 0| 0| 0| 9| 9| 9| 0| 0| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
10 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Inflammation | 2 3 3 3 1 1 1 1 2 3 2 3 1 3 4 1 4 3 1 2|
Dorsal, Cyst, Mucous | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 3 |
Cyst | 4 |
Interstitial Cell, Hyperplasia | 1 1 3 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 3 2 2 3 2 2 3 3 4 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + |
Inguinal, Hyperplasia, Plasma Cell | 4 |
Mediastinal, Atrophy | 2 |
Mediastinal, Ectasia | 1 |
Mediastinal, Pigmentation | |
Pancreatic, Necrosis | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hyperplasia, Plasma Cell | 3 |
Necrosis | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 1 |
Hyperplasia, Reticulum Cell | |
Necrosis | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 3 4 |
Hyperplasia, Lymphoid | |
Hyperplasia, Reticulum Cell | |
Infarct | 4 |
Pigmentation | 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 2 4 4 3 4 4 3 3 4 3 4 3 3 3 3 4 4 4 4 3 3 4 4|
Artery, Inflammation | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 1| 9| 2| 2| 5| 3| 3| 0| 2| 3| 2| 3| 0| 3| 2| 3| 3| 3| 6| 2| 0| 3| 3| 0| 3|
| 7| 6| 9| 9| 9| 0| 0| 8| 9| 0| 9| 0| 1| 0| 9| 0| 0| 0| 9| 9| 9| 0| 0| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
10 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Cyst Epithelial Inclusion | |
Hyperkeratosis | |
Hyperplasia | |
Inflammation | 4 |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 3 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 1 1 1 1 1 1 1 1|
Necrosis | 3 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 2 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X X X |
Inflammation | 1 1 1 2 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Inflammation | 2 |
Nephropathy | 1 2 3 2 1 1 1 1 1 1 2 1 1 1 1 2 1 2 1 1 1 1 2 2 1|
Pigmentation | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 4| 5| 6| 5| 5| 3| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 2| 8| 3| 3| 2| 2| 2| 1| 8| 6| 1| 9| 8| 6| 2| 1| 8| 2| 3| 2| 3| 3| 2| 2| |
| 9| 9| 5| 0| 0| 9| 3| 9| 0| 5| 3| 2| 2| 6| 3| 9| 8| 7| 9| 0| 9| 0| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
10 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X | 6 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X | 29 |
Clear Cell Focus | X X X X X| 11 |
Degeneration, Cystic | 1 | 4 1.0|
Eosinophilic Focus | X X X X X | 8 |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hemorrhage | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | X X | 5 |
Inflammation | 1 1 1 2 1 1 1 1 1 1 1 1 1 2 1 1 1| 27 1.1|
Mixed Cell Focus | X X X X X X X X X X| 17 |
Necrosis | | 1 1.0|
Thrombosis | 4 | 1 4.0|
Vacuolization Cytoplasmic | 1 1 | 4 1.3|
Bile Duct, Hyperplasia | 1 1 1 2 1 1 3 1 1 2 2 1 1 1 1 2 2 2 2 1 1 1 2 2| 47 1.5|
Centrilobular, Degeneration | 2 3 1 2 4 1 2 | 15 2.1|
Centrilobular, Hypertrophy | | 1 1.0|
Centrilobular, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + +| 12 |
Hemorrhage | 4 | 1 4.0|
Inflammation | | 1 2.0|
Fat, Inflammation | | 1 2.0|
Fat, Necrosis | 3 3 3 3| 7 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 1 1 2 1 2 | 14 1.4|
Cytoplasmic Alteration | 1 | 2 1.0|
Hyperplasia | 2 | 2 1.5|
Inflammation | 1 1 1 1 | 4 1.0|
Duct, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 4| 5| 6| 5| 5| 3| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 2| 8| 3| 3| 2| 2| 2| 1| 8| 6| 1| 9| 8| 6| 2| 1| 8| 2| 3| 2| 3| 3| 2| 2| |
| 9| 9| 5| 0| 0| 9| 3| 9| 0| 5| 3| 2| 2| 6| 3| 9| 8| 7| 9| 0| 9| 0| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
10 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 | 1 3.0|
Hyperplasia | 2 2 | 2 2.0|
Inflammation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 2.0|
Erosion | 1 | 1 1.0|
Ulcer | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 1 2 2 1 2 1 1 1 1 1 1 1 2 1 1 1 1 2 2 1 2 2| 46 1.4|
Thrombosis | 2 4 | 5 3.0|
Epicardium, Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 1 1.0|
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hyperplasia | 1 2 1 2 1 2 1| 13 1.4|
Hypertrophy | 1 1 1 2 1| 7 1.1|
Vacuolization Cytoplasmic | 1 1 | 6 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 3 1 | 10 1.6|
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 48 |
Hyperplasia, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 2 | 6 2.5|
Cyst | 1 1 | 8 1.1|
Pars Distalis, Hyperplasia | 2 2 2 1 1 1 1 2| 17 1.9|
Pars Intermedia, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 4 1 1 1 1 1 1 1 1 1 1 1 2 1 2| 30 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 4| 5| 6| 5| 5| 3| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 2| 8| 3| 3| 2| 2| 2| 1| 8| 6| 1| 9| 8| 6| 2| 1| 8| 2| 3| 2| 3| 3| 2| 2| |
| 9| 9| 5| 0| 0| 9| 3| 9| 0| 5| 3| 2| 2| 6| 3| 9| 8| 7| 9| 0| 9| 0| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
10 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + | 1 |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
Mesothelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 2 1 2 2 1 2 2 1 1 2 2 1 2 2 2 2 2 1 2 1 1 2 1 2| 45 1.6|
Duct, Cyst | 1 1| 3 1.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 1.0|
Inflammation | 1 1 3 2 2 1 1 1 1 3 1 3 3 4 2 3 1 1| 38 2.1|
Dorsal, Cyst, Mucous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 4 4 4 | 7 3.9|
Cyst | | 1 4.0|
Interstitial Cell, Hyperplasia | 2 1 1 1 1 2 1 4 2 1 1 1 1 1 1 1 1 1| 37 1.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 2 2 2 1 | 18 2.4|
Myelofibrosis | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 11 |
Inguinal, Hyperplasia, Plasma Cell | | 1 4.0|
Mediastinal, Atrophy | | 1 2.0|
Mediastinal, Ectasia | | 1 1.0|
Mediastinal, Pigmentation | 4 | 1 4.0|
Pancreatic, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 2 1 1 | 5 1.6|
Hyperplasia, Plasma Cell | | 1 3.0|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | | 1 1.0|
Hyperplasia, Reticulum Cell | 2 1 | 2 1.5|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 4| 5| 6| 5| 5| 3| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 2| 8| 3| 3| 2| 2| 2| 1| 8| 6| 1| 9| 8| 6| 2| 1| 8| 2| 3| 2| 3| 3| 2| 2| |
| 9| 9| 5| 0| 0| 9| 3| 9| 0| 5| 3| 2| 2| 6| 3| 9| 8| 7| 9| 0| 9| 0| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
10 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Accessory Spleen | X | 1 |
Fibrosis | 1 1 2| 4 1.5|
Hematopoietic Cell Proliferation | 3 2 2 | 5 2.8|
Hyperplasia, Lymphoid | 4 | 1 4.0|
Hyperplasia, Reticulum Cell | 4 | 1 4.0|
Infarct | | 1 4.0|
Pigmentation | 2 | 2 1.5|
__________________________________________________________________________|____________|
Thymus | M + + + + + + M + + + + M + + + + + + + + + + + +| 47 |
Atrophy | 3 4 3 4 4 4 4 4 2 3 4 3 3 4 3 3 4 3 4 4| 45 3.5|
Artery, Inflammation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 1 1 | 8 1.1|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X | 1 |
Hyperkeratosis | 2 | 1 2.0|
Hyperplasia | 2 | 1 2.0|
Inflammation | | 1 4.0|
Ulcer | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteopetrosis | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 1 1 1 1 | 16 1.0|
Necrosis | | 1 3.0|
Thrombosis | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 1 3 2 1 | 7 1.6|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X X | 6 |
Inflammation | 1 1 1 | 9 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 4| 5| 6| 5| 5| 3| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 2| 8| 3| 3| 2| 2| 2| 1| 8| 6| 1| 9| 8| 6| 2| 1| 8| 2| 3| 2| 3| 3| 2| 2| |
| 9| 9| 5| 0| 0| 9| 3| 9| 0| 5| 3| 2| 2| 6| 3| 9| 8| 7| 9| 0| 9| 0| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
10 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | 2 | 1 2.0|
Inflammation | 1 | 2 1.5|
Nephropathy | 1 2 1 3 1 3 2 1 1 2 1 1 1 1 2 1 3 2 1 1 2 1 2| 48 1.5|
Pigmentation | 2 1 1 | 4 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 4| 7| 7| 7| 5| 7| 5| 6| 7| 7| 6| 7|
DAY ON TEST | 5| 2| 3| 2| 3| 1| 2| 0| 9| 1| 2| 2| 3| 0| 3| 3| 2| 8| 3| 2| 2| 2| 2| 9| 2|
| 7| 3| 0| 9| 0| 5| 9| 8| 1| 4| 9| 9| 0| 0| 0| 0| 9| 5| 0| 3| 1| 1| 5| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
30 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 |
Parasite Metazoan | X X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X|
Degeneration, Cystic | 1 1 1 |
Eosinophilic Focus | X X X X |
Fibrosis | |
Hematopoietic Cell Proliferation | 1 |
Hemorrhage | |
Hepatodiaphragmatic Nodule | X X X X X |
Inflammation | 1 1 1 1 1 1 2 2 1 1 1 1 1|
Mixed Cell Focus | X X X X|
Necrosis | 1 |
Thrombosis | 2 |
Vacuolization Cytoplasmic | 1 2 |
Bile Duct, Hyperplasia | 4 1 2 3 1 1 1 1 1 2 2 2 1 2 1 1 1 3 1 1 1|
Centrilobular, Degeneration | 3 3 2 3 2 1 |
Centrilobular, Hypertrophy | 1 1 1|
Centrilobular, Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Hemorrhage | 4 |
Inflammation | 2 |
Fat, Necrosis | 2 3 2 3 |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 1 1 2 1 1 2 1|
Inflammation | 1 1 1 1 |
Necrosis | |
Thrombosis | |
Artery, Inflammation | 2 |
Duct, Cyst | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 4| 7| 7| 7| 5| 7| 5| 6| 7| 7| 6| 7|
DAY ON TEST | 5| 2| 3| 2| 3| 1| 2| 0| 9| 1| 2| 2| 3| 0| 3| 3| 2| 8| 3| 2| 2| 2| 2| 9| 2|
| 7| 3| 0| 9| 0| 5| 9| 8| 1| 4| 9| 9| 0| 0| 0| 0| 9| 5| 0| 3| 1| 1| 5| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
30 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Hyperplasia | 1 |
Ulcer | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 1 |
Mineralization | |
Ulcer | 1 1 |
__________________________________________________________________________|
Tooth | |
Gingiva, Inflammation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 2 1 1 2 1 1 1 2 2 2 1 1 1 1 2 1 2 1 3|
Thrombosis | 3 4 2|
Artery, Inflammation | 2 |
Endocardium, Degeneration | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1|
Atrophy | |
Hyperplasia | 2 1 1 2 1|
Hypertrophy | 1 1 |
Vacuolization Cytoplasmic | 2 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia | 1 1 1 4 2 2 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 3 |
Cyst | 1 1 1 |
Hemorrhage | 4 |
Pars Distalis, Hyperplasia | 4 2 3 1 2 3 2 3 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 1 2 2 2 1 4 1 1 1 1 1 1|
Follicular Cell, Hyperplasia | 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 4| 7| 7| 7| 5| 7| 5| 6| 7| 7| 6| 7|
DAY ON TEST | 5| 2| 3| 2| 3| 1| 2| 0| 9| 1| 2| 2| 3| 0| 3| 3| 2| 8| 3| 2| 2| 2| 2| 9| 2|
| 7| 3| 0| 9| 0| 5| 9| 8| 1| 4| 9| 9| 0| 0| 0| 0| 9| 5| 0| 3| 1| 1| 5| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
30 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
Mesothelium, Hyperplasia | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 3 4 |
Inflammation | 2 2 1 2 2 1 1 1 1 2 1 2 2 2 2 1 2 2 1 2 2 2 2 2|
Duct, Cyst | 3 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 4 2 3 1 1 3 1 2 3 2 3 1 3 |
Dorsal, Cyst, Mucous | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 |
Interstitial Cell, Hyperplasia | 1 2 1 2 2 1 2 1 1 1 1 1 1 2 2 1 |
Mesothelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 2 3 2 2 3 2|
Inflammation, Granulomatous | 1 |
Myelofibrosis | |
Necrosis | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Mediastinal, Pigmentation | 1 1 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 1 2 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 1 |
Hematopoietic Cell Proliferation | 2 1 |
Hyperplasia, Reticulum Cell | 4 |
Infarct | |
Infiltration Cellular, Lipocyte | 2 |
Pigmentation | 2 |
Lymphoid Follicle, Atrophy | 3 |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + M + + + + + + + + + + M|
Atrophy | 4 4 3 3 3 3 3 4 3 3 3 3 3 4 4 4 3 4 4 4 3 |
Epithelial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hyperplasia | 1 1 2 1 1 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 4| 7| 7| 7| 5| 7| 5| 6| 7| 7| 6| 7|
DAY ON TEST | 5| 2| 3| 2| 3| 1| 2| 0| 9| 1| 2| 2| 3| 0| 3| 3| 2| 8| 3| 2| 2| 2| 2| 9| 2|
| 7| 3| 0| 9| 0| 5| 9| 8| 1| 4| 9| 9| 0| 0| 0| 0| 9| 5| 0| 3| 1| 1| 5| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
30 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Inflammation | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Inflammation | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gliosis | |
Hemorrhage | 1 2 |
Necrosis | 1 2 2 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Foreign Body | X |
Hemorrhage | 1 |
Inflammation | 1 1 1 1 1 1 1 1 |
Thrombosis | 1 |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Inflammation | 2 2 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | +|
Cataract | 2|
Retina, Degeneration | 3|
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 2 |
Necrosis | 4 |
Nephropathy | 1 1 1 2 1 2 2 1 1 1 1 2 2 1 2 1 1 1 1 2 1 1 2|
Pigmentation | 1 1 1 1 1 |
Thrombosis | |
Pelvis, Inflammation | |
__________________________________________________________________________|
Urethra | + |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 4| 7| 7| 7| 5| 7| 5| 6| 7| 7| 6| 7|
DAY ON TEST | 5| 2| 3| 2| 3| 1| 2| 0| 9| 1| 2| 2| 3| 0| 3| 3| 2| 8| 3| 2| 2| 2| 2| 9| 2|
| 7| 3| 0| 9| 0| 5| 9| 8| 1| 4| 9| 9| 0| 0| 0| 0| 9| 5| 0| 3| 1| 1| 5| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
30 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Inflammation | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 3 1 |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 6| 7| 6| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 5| 6| 4| 6| 4| 7| |
DAY ON TEST | 6| 3| 2| 3| 3| 1| 4| 2| 5| 3| 8| 0| 3| 7| 0| 3| 0| 2| 6| 4| 7| 8| 0| 4| 0| |
| 2| 0| 9| 0| 0| 2| 6| 9| 3| 7| 2| 8| 0| 5| 8| 0| 1| 9| 3| 9| 6| 2| 2| 4| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
30 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 2 1.0|
Parasite Metazoan | X X X X | 8 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 1.0|
Basophilic Focus | X X X X X X X X X X | 26 |
Clear Cell Focus | | 2 |
Degeneration, Cystic | 1 | 4 1.0|
Eosinophilic Focus | X X | 6 |
Fibrosis | 1 | 1 1.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Hemorrhage | 1 | 1 1.0|
Hepatodiaphragmatic Nodule | X X X X X | 10 |
Inflammation | 1 1 1 1 2 1 | 19 1.2|
Mixed Cell Focus | X X X X| 8 |
Necrosis | 1 1 | 3 1.0|
Thrombosis | 2 | 2 2.0|
Vacuolization Cytoplasmic | | 2 1.5|
Bile Duct, Hyperplasia | 3 1 2 3 1 3 2 1 2 2 1 2 1 2 2 2 3 2 3 1 1 1 3| 44 1.8|
Centrilobular, Degeneration | 1 1 4 2 2 1 1 2 1 3 2 1 2 4| 20 2.1|
Centrilobular, Hypertrophy | | 3 1.0|
Centrilobular, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 12 |
Hemorrhage | | 1 4.0|
Inflammation | | 1 2.0|
Fat, Necrosis | 2 3 3 3 | 8 2.6|
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 2 1 1 | 13 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 6| 7| 6| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 5| 6| 4| 6| 4| 7| |
DAY ON TEST | 6| 3| 2| 3| 3| 1| 4| 2| 5| 3| 8| 0| 3| 7| 0| 3| 0| 2| 6| 4| 7| 8| 0| 4| 0| |
| 2| 0| 9| 0| 0| 2| 6| 9| 3| 7| 2| 8| 0| 5| 8| 0| 1| 9| 3| 9| 6| 2| 2| 4| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
30 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation | | 4 1.0|
Necrosis | 2 | 1 2.0|
Thrombosis | 1 | 1 1.0|
Artery, Inflammation | 3 | 2 2.5|
Duct, Cyst | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 2.0|
Hyperplasia | | 1 1.0|
Ulcer | 2 1| 3 1.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 1 1| 4 1.0|
Mineralization | 1 | 1 1.0|
Ulcer | 3 1 | 4 1.5|
__________________________________________________________________________|____________|
Tooth | + | 1 |
Gingiva, Inflammation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 1 2 2 1 1 1 1 1 2 2 2 2 1 1 1 2 2 1 1 | 43 1.4|
Thrombosis | 2 4| 5 3.0|
Artery, Inflammation | | 1 2.0|
Endocardium, Degeneration | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 2 1.0|
Atrophy | 2 | 1 2.0|
Hyperplasia | 1 1 1 | 8 1.3|
Hypertrophy | 1 | 3 1.0|
Vacuolization Cytoplasmic | 2 1 | 4 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4 | 1 4.0|
Hyperplasia | 3 2 1 4 3 4 1| 15 2.2|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 6| 7| 6| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 5| 6| 4| 6| 4| 7| |
DAY ON TEST | 6| 3| 2| 3| 3| 1| 4| 2| 5| 3| 8| 0| 3| 7| 0| 3| 0| 2| 6| 4| 7| 8| 0| 4| 0| |
| 2| 0| 9| 0| 0| 2| 6| 9| 3| 7| 2| 8| 0| 5| 8| 0| 1| 9| 3| 9| 6| 2| 2| 4| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
30 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Angiectasis | 1 2 4| 6 2.3|
Cyst | 1 1 1 1 1 1 1 | 10 1.0|
Hemorrhage | 2 | 2 3.0|
Pars Distalis, Hyperplasia | 2 4 1 2 2 1 2 2 4 1 2| 21 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 4 1 1 1 1 1 2 2 1 1 1 1 | 26 1.5|
Follicular Cell, Hyperplasia | 2 | 3 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 1.0|
Mesothelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 4 3.5|
Inflammation | 2 2 1 1 2 2 2 1 2 2 2 1 2 1 1 2 1 2 2 1 1 1 2 2| 48 1.6|
Duct, Cyst | | 2 3.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 2 1 1 2 1 1 1 2 2 2 1 2 3 1 3 2 1| 31 1.9|
Dorsal, Cyst, Mucous | | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 3 3.3|
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 | 28 1.2|
Mesothelium, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 3 4 3 2 2 2 | 16 2.6|
Inflammation, Granulomatous | | 1 1.0|
Myelofibrosis | 3 | 1 3.0|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 14 |
Mediastinal, Pigmentation | 4 | 4 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
Ectasia | | 3 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 6| 7| 6| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 5| 6| 4| 6| 4| 7| |
DAY ON TEST | 6| 3| 2| 3| 3| 1| 4| 2| 5| 3| 8| 0| 3| 7| 0| 3| 0| 2| 6| 4| 7| 8| 0| 4| 0| |
| 2| 0| 9| 0| 0| 2| 6| 9| 3| 7| 2| 8| 0| 5| 8| 0| 1| 9| 3| 9| 6| 2| 2| 4| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
30 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 1 | 4 1.3|
Hematopoietic Cell Proliferation | 3 | 3 2.0|
Hyperplasia, Reticulum Cell | | 1 4.0|
Infarct | 2 | 1 2.0|
Infiltration Cellular, Lipocyte | | 1 2.0|
Pigmentation | 2 | 2 2.0|
Lymphoid Follicle, Atrophy | 2 2 | 3 2.3|
__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + + + + + + + + + + + + + + + +| 46 |
Atrophy | 3 4 4 4 4 3 4 3 4 3 4 4 4 4 4 4 2 4 4| 40 3.6|
Epithelial Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 |
Cyst | | 1 2.0|
Hyperplasia | 1 2 1 1| 9 1.2|
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 3.0|
Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Gliosis | 2| 1 2.0|
Hemorrhage | 3 2 | 4 2.0|
Necrosis | 2 | 4 1.8|
Thrombosis | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 1 | 1 1.0|
Foreign Body | | 1 |
Hemorrhage | 1 2 | 3 1.3|
Inflammation | 1 1 2 1 1 2 | 14 1.1|
Thrombosis | 1 | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 6| 7| 6| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 5| 6| 4| 6| 4| 7| |
DAY ON TEST | 6| 3| 2| 3| 3| 1| 4| 2| 5| 3| 8| 0| 3| 7| 0| 3| 0| 2| 6| 4| 7| 8| 0| 4| 0| |
| 2| 0| 9| 0| 0| 2| 6| 9| 3| 7| 2| 8| 0| 5| 8| 0| 1| 9| 3| 9| 6| 2| 2| 4| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
30 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar Epithelium, Hyperplasia | 4 | 2 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X X | 3 |
Inflammation | 2 1 | 6 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cataract | | 1 2.0|
Retina, Degeneration | | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | 2 1 | 3 1.7|
Necrosis | 3 | 2 3.5|
Nephropathy | 2 2 2 2 1 1 1 1 1 2 1 2 1 1 2 1 1 1| 41 1.4|
Pigmentation | 1 2 1 2 1 1 1 2 2 1 | 15 1.3|
Thrombosis | 4 | 1 4.0|
Pelvis, Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urethra | | 1 |
Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 2 2.0|
Transitional Epithelium, Hyperplasia | 1 1 | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 5| 7| 6| 5| 6| 6| 7| 6| 6| 5| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 2| 2| 2| 9| 9| 2| 3| 3| 3| 6| 2| 7| 8| 5| 1| 3| 3| 3| 6| 2| 2| 3| 0| 9|
| 9| 9| 9| 9| 0| 9| 9| 7| 0| 0| 2| 9| 6| 5| 9| 0| 0| 2| 4| 9| 3| 9| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
100 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
Ulcer | 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X|
Clear Cell Focus | X X |
Degeneration, Cystic | 1 1 |
Eosinophilic Focus | X X X X X X |
Fibrosis | 1 |
Hematopoietic Cell Proliferation | 1 |
Hemorrhage | 2 |
Hepatodiaphragmatic Nodule | X |
Inflammation | 1 1 1 1 1 1 1 1 1 1|
Mixed Cell Focus | X X X X X X |
Necrosis | 1 3 2 |
Vacuolization Cytoplasmic | 2 1 |
Bile Duct, Hyperplasia | 2 1 2 2 2 2 2 1 2 1 1 2 3 3 3 1 3 3 3 2 1 2 3 1|
Centrilobular, Degeneration | 2 1 2 2 2 2 2 2 2 4 4 |
Centrilobular, Hypertrophy | 1 2 2 1 2 2 1 1 |
__________________________________________________________________________|
Mesentery | + + + + + + + |
Fat, Inflammation | 1 |
Fat, Necrosis | 3 3 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 2 1 1 |
Cytoplasmic Alteration | |
Hyperplasia | 2 |
Inflammation | 1 |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Ulcer | 3 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 5| 7| 6| 5| 6| 6| 7| 6| 6| 5| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 2| 2| 2| 9| 9| 2| 3| 3| 3| 6| 2| 7| 8| 5| 1| 3| 3| 3| 6| 2| 2| 3| 0| 9|
| 9| 9| 9| 9| 0| 9| 9| 7| 0| 0| 2| 9| 6| 5| 9| 0| 0| 2| 4| 9| 3| 9| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
100 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mineralization | 2 |
Necrosis | 3 |
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Inflammation | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 1 2 1 1 2 1 1 2 1 1 1 1 1 1 2 1 1 2 1|
Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Degeneration, Cystic | |
Hyperplasia | 1|
Hypertrophy | 1 |
Vacuolization Cytoplasmic | 1 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 1 4 1 3 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + M + + + + M M + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 2 |
Cyst | 1 2 |
Pars Distalis, Hyperplasia | 2 2 1 2 1 2 2 |
Pars Distalis, Pseudocyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 2 1 4 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation | 2 2 2 2 2 2 1 2 1 2 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2|
Duct, Cyst | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 3 2 2 1 2 3 2 1 3 2 1 2 2 2 1 1|
Dorsal, Cyst, Mucous | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 5| 7| 6| 5| 6| 6| 7| 6| 6| 5| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 2| 2| 2| 9| 9| 2| 3| 3| 3| 6| 2| 7| 8| 5| 1| 3| 3| 3| 6| 2| 2| 3| 0| 9|
| 9| 9| 9| 9| 0| 9| 9| 7| 0| 0| 2| 9| 6| 5| 9| 0| 0| 2| 4| 9| 3| 9| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
100 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Atrophy | 4 4 4 |
Interstitial Cell, Hyperplasia | 2 3 3 1 2 1 1 1 1 1 1 4 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 3 4 2 2 3 3 2 1 3 |
Myelofibrosis | 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + +|
Mediastinal, Hemorrhage | 3|
Mediastinal, Pigmentation | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
Fibrosis | 1 1 2 1 |
Hematopoietic Cell Proliferation | 3 3 3 2 |
Infarct | |
Necrosis | 2 |
Pigmentation | 1 |
Lymphoid Follicle, Atrophy | 3 3|
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + M + + + + + + + + +|
Atrophy | 4 3 4 4 3 4 4 3 3 4 4 4 4 4 4 4 4 4 3 3 4 4 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | |
Hyperplasia | 1 2 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hyperkeratosis | |
Inflammation | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gliosis | 1 |
Hemorrhage | 2 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 5| 7| 6| 5| 6| 6| 7| 6| 6| 5| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 2| 2| 2| 9| 9| 2| 3| 3| 3| 6| 2| 7| 8| 5| 1| 3| 3| 3| 6| 2| 2| 3| 0| 9|
| 9| 9| 9| 9| 0| 9| 9| 7| 0| 0| 2| 9| 6| 5| 9| 0| 0| 2| 4| 9| 3| 9| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
100 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Foreign Body | |
Hemorrhage | 1 2 |
Inflammation | 1 1 1 1 1 1 1 1 3 1 1 3 |
Alveolar Epithelium, Hyperplasia | 4 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X X |
Inflammation | 1 1 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 2 |
Retina, Degeneration | 4 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 1 |
Nephropathy | 2 2 1 1 1 2 1 3 2 1 2 1 2 2 1 2 2 1 1 1 1 1 |
Pigmentation | 1 1 2 3 1 3 3 1 3 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 2| 2| 3| 3| 2| 2| 6| 0| 3| 7| 2| 2| 3| 3| 2| 3| 9| 3| 3| 2| 2| 3| 3| 2| 6| |
| 9| 2| 0| 0| 9| 9| 9| 2| 3| 7| 9| 9| 0| 0| 9| 0| 1| 0| 0| 9| 9| 0| 0| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
100 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X X X| 7 |
Ulcer | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X| 27 |
Clear Cell Focus | X X | 4 |
Degeneration, Cystic | 1 1 1 2 | 6 1.2|
Eosinophilic Focus | X X | 8 |
Fibrosis | | 1 1.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Hemorrhage | | 1 2.0|
Hepatodiaphragmatic Nodule | X X X | 4 |
Inflammation | 1 1 2 1 1 1 1 1 1 1 1| 21 1.0|
Mixed Cell Focus | X X X X X | 11 |
Necrosis | 1 | 4 1.8|
Vacuolization Cytoplasmic | 1 1 1 | 5 1.2|
Bile Duct, Hyperplasia | 2 2 1 1 2 1 3 1 3 3 2 1 2 3 1 1 2 1 1 3 2 2 1 1| 48 1.9|
Centrilobular, Degeneration | 2 4 2 3 1 3 2 2 2 2 1 1 | 23 2.2|
Centrilobular, Hypertrophy | 1 2 1 1 1 1 1 1| 16 1.3|
__________________________________________________________________________|____________|
Mesentery | + + + + + + +| 14 |
Fat, Inflammation | 3 | 2 2.0|
Fat, Necrosis | 2 3 3 | 7 2.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 1 1 1 1 1 | 12 1.1|
Cytoplasmic Alteration | 1 | 1 1.0|
Hyperplasia | 3 | 2 2.5|
Inflammation | 1 | 2 1.0|
Duct, Cyst | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cytoplasmic Alteration | 1 1 | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 2| 2| 3| 3| 2| 2| 6| 0| 3| 7| 2| 2| 3| 3| 2| 3| 9| 3| 3| 2| 2| 3| 3| 2| 6| |
| 9| 2| 0| 0| 9| 9| 9| 2| 3| 7| 9| 9| 0| 0| 9| 0| 1| 0| 0| 9| 9| 0| 0| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
100 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 | 1 2.0|
Ulcer | | 2 3.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 1 | 3 1.3|
Mineralization | | 1 2.0|
Necrosis | | 1 3.0|
Ulcer | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 2 2 2 2 2 1 2 1 2 1 1 1 2 1 1 2 2 2 1| 43 1.4|
Thrombosis | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 1 1.0|
Degeneration, Cystic | 1 | 1 1.0|
Hyperplasia | 1 1 1 2 1 1 1 1 | 9 1.1|
Hypertrophy | 1 | 2 1.0|
Vacuolization Cytoplasmic | | 3 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 4 1 1 2 | 12 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 3 2.7|
Cyst | 1 1 1 1| 6 1.2|
Pars Distalis, Hyperplasia | 4 2 1 2 3 4 1 1| 15 2.0|
Pars Distalis, Pseudocyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 1 1 2 1 4 2 1 4 1 | 20 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | +| 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 2| 2| 3| 3| 2| 2| 6| 0| 3| 7| 2| 2| 3| 3| 2| 3| 9| 3| 3| 2| 2| 3| 3| 2| 6| |
| 9| 2| 0| 0| 9| 9| 9| 2| 3| 7| 9| 9| 0| 0| 9| 0| 1| 0| 0| 9| 9| 0| 0| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
100 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 4 | 2 3.5|
Inflammation | 2 2 2 2 2 2 2 2 2 1 1 1 1 1 2 1 2 2 2 2 2 1 2| 48 1.7|
Duct, Cyst | 2 4 | 2 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 3 1 1 3 2 3 1 2 2 3 2| 29 1.9|
Dorsal, Cyst, Mucous | | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 4 4 | 6 4.0|
Interstitial Cell, Hyperplasia | 2 1 1 1 1 1 1 1 1 1 1| 24 1.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 2 2 3 2 3 3 2| 20 2.5|
Myelofibrosis | 2 | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + +| 14 |
Mediastinal, Hemorrhage | | 1 3.0|
Mediastinal, Pigmentation | 2 3| 3 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + + + + + +| 49 |
Atrophy | | 1 3.0|
Ectasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | X X | 2 |
Fibrosis | 2 | 5 1.4|
Hematopoietic Cell Proliferation | 3 | 5 2.8|
Infarct | 2 | 1 2.0|
Necrosis | | 1 2.0|
Pigmentation | | 1 1.0|
Lymphoid Follicle, Atrophy | | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +| 47 |
Atrophy | 3 4 3 3 3 4 4 4 3 3 3 3 3 3 3 3 4 3 4 4| 43 3.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 1 4 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 2| 2| 3| 3| 2| 2| 6| 0| 3| 7| 2| 2| 3| 3| 2| 3| 9| 3| 3| 2| 2| 3| 3| 2| 6| |
| 9| 2| 0| 0| 9| 9| 9| 2| 3| 7| 9| 9| 0| 0| 9| 0| 1| 0| 0| 9| 9| 0| 0| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
100 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Hyperplasia | 1 1 4 | 6 1.7|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 3.0|
Hyperkeratosis | 2 | 1 2.0|
Inflammation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteopetrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | +| 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Gliosis | | 1 1.0|
Hemorrhage | 1 | 3 1.7|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 2.0|
Foreign Body | X | 1 |
Hemorrhage | 1 1 | 4 1.3|
Inflammation | 1 2 1 1 1 1 | 18 1.3|
Alveolar Epithelium, Hyperplasia | 2 1 | 5 1.8|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X X | 5 |
Inflammation | 1 2 1 | 8 1.1|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cataract | | 1 2.0|
Retina, Degeneration | | 1 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | | 1 1.0|
Nephropathy | 1 2 2 2 1 2 1 1 2 2 1 2 2 1 2 1 2 1 1 3 2 1| 44 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:57:41
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 2| 2| 3| 3| 2| 2| 6| 0| 3| 7| 2| 2| 3| 3| 2| 3| 9| 3| 3| 2| 2| 3| 3| 2| 6| |
| 9| 2| 0| 0| 9| 9| 9| 2| 3| 7| 9| 9| 0| 0| 9| 0| 1| 0| 0| 9| 9| 0| 0| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
100 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Pigmentation | 1 1 1 1 1 1 1 1 1 | 19 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
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