TDMS Study 88120-04 Pathology Tables
NTP Experiment-Test: 88120-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 09/24/99
Route: DOSED FEED Time: 08:20:21
CORE STUDY
Facility: Battelle Columbus Laboratory
Chemical CAS #: 80-07-9
Lock Date: 08/11/98
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 88120-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 09/24/99
Route: DOSED FEED Time: 08:20:21
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 30 PPM 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Natural Death 5 9 6 4
Moribund Sacrifice 3 1 1 1
Survivors
Terminal Sacrifice 42 40 43 45
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (50) (50) (50)
Lymphoid Tissue, Hyperplasia, Lymphoid 1 (2%)
Serosa, Inflammation, Chronic 1 (2%)
Intestine Small, Jejunum (50) (50) (50) (50)
Peyer's Patch, Hyperplasia, Lymphoid 2 (4%) 4 (8%)
Liver (50) (50) (50) (50)
Angiectasis 1 (2%)
Basophilic Focus 1 (2%) 2 (4%)
Clear Cell Focus 2 (4%) 1 (2%) 1 (2%)
Eosinophilic Focus 2 (4%) 1 (2%) 4 (8%) 11 (22%)
Eosinophilic Focus, Multiple 3 (6%)
Fatty Change, Diffuse 3 (6%) 1 (2%)
Infiltration Cellular, Mononuclear Cell 8 (16%) 9 (18%) 12 (24%) 10 (20%)
Inflammation, Chronic Active 4 (8%) 6 (12%) 3 (6%) 9 (18%)
Inflammation, Granulomatous 1 (2%)
Mixed Cell Focus 1 (2%) 1 (2%) 2 (4%)
Mixed Cell Focus, Multiple 1 (2%)
Necrosis 1 (2%)
Necrosis, Focal 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Tension Lipidosis 4 (8%) 1 (2%)
Vacuolization Cytoplasmic, Focal 1 (2%) 1 (2%) 2 (4%)
Bile Duct, Cyst 1 (2%)
Centrilobular, Fatty Change 1 (2%)
Centrilobular, Hypertrophy 9 (18%) 29 (58%)
Oval Cell, Hyperplasia 1 (2%)
Periportal, Degeneration 1 (2%)
Periportal, Fibrosis 1 (2%)
Periportal, Hyperplasia, Lymphoid 1 (2%)
Serosa, Hyperplasia, Lymphoid 1 (2%)
Mesentery (5) (2) (5) (5)
Fat, Necrosis 4 (80%) 1 (50%) 3 (60%) 4 (80%)
Oral Mucosa (31) (21) (37) (37)
Ulcer 14 (45%) 7 (33%) 17 (46%) 18 (49%)
Gingival, Inflammation, Chronic 31 (100%) 21 (100%) 37 (100%) 36 (97%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88120-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 09/24/99
Route: DOSED FEED Time: 08:20:21
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 30 PPM 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Pancreas (50) (49) (50) (50)
Amyloid Deposition 1 (2%)
Hypertrophy, Focal 1 (2%)
Inflammation, Chronic 2 (4%) 1 (2%)
Acinus, Atrophy 1 (2%) 1 (2%)
Duct, Cyst 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Cyst 1 (2%)
Hyperkeratosis, Focal 1 (2%)
Mineralization 1 (2%)
Epithelium, Hyperplasia, Focal 2 (4%)
Muscularis, Hyperplasia, Focal 1 (2%)
Stomach, Glandular (50) (50) (50) (50)
Ulcer 1 (2%)
Epithelium, Cyst 2 (4%)
Epithelium, Hyperplasia, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (50)
Aorta, Inflammation, Chronic 1 (2%)
Aorta, Mineralization 1 (2%)
Pulmonary Vein, Inflammation, Chronic 1 (2%)
Heart (50) (50) (50) (50)
Artery, Inflammation, Chronic 1 (2%) 2 (4%)
Epicardium, Inflammation, Chronic 1 (2%)
Myocardium, Degeneration 1 (2%) 1 (2%) 2 (4%)
Myocardium, Mineralization 1 (2%)
Nerve, Inflammation, Chronic 1 (2%)
Valve, Inflammation 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (49) (50) (50)
Cytoplasmic Alteration, Focal 1 (2%)
Hyperplasia, Focal 1 (2%) 1 (2%)
Hypertrophy, Diffuse 1 (2%) 1 (2%)
Hypertrophy, Focal 2 (4%) 3 (6%)
Subcapsular, Hyperplasia 47 (94%) 47 (96%) 50 (100%) 47 (94%)
Islets, Pancreatic (50) (50) (50) (50)
Hyperplasia 4 (8%) 2 (4%) 3 (6%) 2 (4%)
Pituitary Gland (48) (46) (48) (48)
Inflammation, Suppurative 1 (2%)
Pars Distalis, Hemorrhage 1 (2%)
Pars Distalis, Hyperplasia, Focal 5 (10%) 6 (13%) 7 (15%) 11 (23%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88120-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 09/24/99
Route: DOSED FEED Time: 08:20:21
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 30 PPM 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Vacuolization Cytoplasmic 1 (2%)
Thyroid Gland (50) (49) (50) (50)
Hyperplasia, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (50) (50) (49)
Atrophy 1 (2%)
Cyst 1 (2%) 3 (6%) 1 (2%)
Ovary (50) (48) (49) (48)
Angiectasis 2 (4%) 7 (15%) 2 (4%) 1 (2%)
Cyst 15 (30%) 11 (23%) 16 (33%) 9 (19%)
Hemorrhage 7 (14%) 4 (8%)
Inflammation, Granulomatous 1 (2%)
Inflammation, Suppurative 1 (2%) 2 (4%)
Thrombosis 1 (2%) 4 (8%) 1 (2%)
Uterus (50) (50) (50) (50)
Angiectasis 1 (2%) 1 (2%)
Inflammation, Granulomatous 2 (4%)
Inflammation, Suppurative 3 (6%) 2 (4%) 7 (14%) 11 (22%)
Thrombosis 1 (2%)
Ulcer 1 (2%) 1 (2%) 1 (2%)
Endometrium, Hyperplasia, Cystic 41 (82%) 44 (88%) 48 (96%) 47 (94%)
Epithelium, Metaplasia, Squamous 1 (2%)
Serosa, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Necrosis 1 (2%)
Lymph Node (3) (6) (4) (4)
Lumbar, Hyperplasia, Lymphoid 1 (17%) 2 (50%) 1 (25%)
Renal, Hyperplasia, Lymphoid 1 (17%) 1 (25%) 2 (50%)
Lymph Node, Mandibular (47) (47) (50) (50)
Hyperplasia, Lymphoid 1 (2%)
Lymph Node, Mesenteric (50) (46) (49) (46)
Erythrophagocytosis 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 4 (8%) 1 (2%) 3 (6%) 1 (2%)
Infiltration Cellular, Plasma Cell 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88120-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 09/24/99
Route: DOSED FEED Time: 08:20:21
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 30 PPM 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Vein, Ectasia 1 (2%)
Spleen (49) (49) (50) (50)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 11 (22%) 15 (31%) 11 (22%) 21 (42%)
Lymphoid Follicle, Atrophy 5 (10%) 7 (14%) 4 (8%) 2 (4%)
Lymphoid Follicle, Hyperplasia 10 (20%) 9 (18%) 11 (22%) 8 (16%)
Thymus (49) (48) (50) (50)
Atrophy 28 (57%) 25 (52%) 26 (52%) 33 (66%)
Cyst 4 (8%) 4 (8%) 4 (8%) 7 (14%)
Hyperplasia, Lymphoid 2 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Hyperplasia 1 (2%) 2 (4%)
Skin (50) (50) (50) (50)
Infiltration Cellular, Mast Cell 1 (2%)
Subcutaneous Tissue, Edema 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrosis 10 (20%) 4 (8%) 12 (24%) 15 (30%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (49) (50) (50)
Hypothalamus, Degeneration 1 (2%) 1 (2%)
Thalamus, Necrosis, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia 1 (2%)
Infiltration Cellular, Histiocyte 2 (4%) 1 (2%)
Inflammation, Chronic, Focal 2 (4%)
Inflammation, Granulomatous 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 1 (2%) 1 (2%) 2 (4%)
Bronchiole, Hyperplasia 1 (2%)
Serosa, Fibrosis 1 (2%)
Nose (50) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88120-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 09/24/99
Route: DOSED FEED Time: 08:20:21
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 30 PPM 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Hemorrhage 2 (4%)
Inflammation, Granulomatous 1 (2%)
Respiratory Epithelium, Cytoplasmic
Alteration 1 (2%)
Turbinate, Inflammation, Suppurative 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (3) (3) (1)
Atrophy 2 (67%) 1 (33%)
Degeneration 1 (33%) 2 (67%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Amyloid Deposition 1 (2%)
Glomerulosclerosis 1 (2%)
Hydronephrosis 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Infarct 3 (6%) 2 (4%) 2 (4%)
Inflammation, Chronic, Focal 1 (2%) 1 (2%)
Inflammation, Focal, Suppurative 1 (2%)
Renal Tubule, Accumulation, Hyaline Droplet 1 (2%)
Renal Tubule, Casts Protein 32 (64%) 30 (60%) 31 (62%) 38 (76%)
Renal Tubule, Hyperplasia, Focal 2 (4%)
Renal Tubule, Necrosis, Acute 1 (2%)
Renal Tubule, Regeneration 1 (2%) 1 (2%)
Urinary Bladder (50) (50) (50) (50)
Hyperplasia, Lymphoid 1 (2%)
Serosa, Inflammation, Granulomatous 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88120-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 09/24/99
Route: DOSED FEED Time: 08:20:21
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 30 PPM 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Natural Death 9 3 4 5
Moribund Sacrifice 1 2 2 3
Survivors
Terminal Sacrifice 40 45 43 42
Natural Death 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Duodenum (50) (50) (49) (50)
Epithelium, Necrosis 1 (2%)
Intestine Small, Jejunum (50) (50) (50) (50)
Congestion 1 (2%) 1 (2%)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%)
Intestine Small, Ileum (50) (50) (50) (50)
Congestion 1 (2%)
Liver (50) (50) (50) (50)
Basophilic Focus 3 (6%) 4 (8%) 1 (2%)
Clear Cell Focus 4 (8%) 6 (12%) 3 (6%) 4 (8%)
Clear Cell Focus, Multiple 1 (2%)
Eosinophilic Focus 2 (4%) 8 (16%) 6 (12%) 6 (12%)
Eosinophilic Focus, Multiple 3 (6%) 1 (2%) 1 (2%) 2 (4%)
Fatty Change, Diffuse 2 (4%)
Fatty Change, Focal 1 (2%)
Hemorrhage 1 (2%)
Hepatodiaphragmatic Nodule 1 (2%)
Infarct 1 (2%)
Inflammation, Focal, Suppurative 4 (8%)
Inflammation, Granulomatous 1 (2%) 1 (2%)
Mixed Cell Focus 1 (2%) 3 (6%) 3 (6%)
Mixed Cell Focus, Multiple 1 (2%)
Necrosis, Focal 1 (2%) 1 (2%) 2 (4%) 4 (8%)
Tension Lipidosis 4 (8%) 1 (2%) 3 (6%) 1 (2%)
Vacuolization Cytoplasmic 1 (2%) 1 (2%)
Vacuolization Cytoplasmic, Focal 1 (2%)
Bile Duct, Cyst 1 (2%)
Centrilobular, Degeneration 1 (2%)
Centrilobular, Hypertrophy 1 (2%) 24 (48%) 43 (86%) 45 (90%)
Centrilobular, Necrosis 2 (4%)
Vein, Congestion 1 (2%)
Mesentery (3) (2) (1)
Inflammation, Granulomatous 1 (33%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88120-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 09/24/99
Route: DOSED FEED Time: 08:20:21
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 30 PPM 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Fat, Necrosis 2 (67%) 2 (100%) 1 (100%)
Oral Mucosa (50) (50) (50) (50)
Ulcer 23 (46%) 27 (54%) 25 (50%) 18 (36%)
Gingival, Inflammation, Chronic 37 (74%) 36 (72%) 34 (68%) 33 (66%)
Pancreas (50) (49) (50) (49)
Inflammation, Chronic 3 (6%) 1 (2%) 1 (2%)
Acinus, Atrophy 1 (2%)
Acinus, Hypertrophy, Focal 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Hyperplasia, Diffuse 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Ulcer 1 (2%)
Epithelium, Hyperplasia, Focal 2 (4%)
Stomach, Glandular (50) (50) (50) (50)
Erosion 1 (2%)
Ulcer 1 (2%)
Epithelium, Hypertrophy 1 (2%)
Tooth (1) (1)
Inflammation, Suppurative 1 (100%)
Malformation 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (50)
Aorta, Mineralization 1 (2%)
Heart (50) (50) (50) (50)
Infiltration Cellular, Focal, Lymphocyte 1 (2%)
Artery, Inflammation, Chronic 1 (2%) 1 (2%) 4 (8%)
Artery, Coronary Artery, Thrombosis 1 (2%)
Atrium, Thrombosis 1 (2%)
Myocardium, Degeneration 3 (6%) 1 (2%) 1 (2%)
Myocardium, Mineralization 3 (6%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (50) (50) (50)
Atrophy 1 (2%)
Cytoplasmic Alteration, Focal 10 (20%) 13 (26%) 11 (22%) 7 (14%)
Hyperplasia, Focal 3 (6%) 4 (8%) 1 (2%) 3 (6%)
Hypertrophy, Focal 14 (29%) 16 (32%) 21 (42%) 15 (30%)
Subcapsular, Hyperplasia 40 (82%) 42 (84%) 41 (82%) 44 (88%)
Islets, Pancreatic (50) (49) (49) (49)
Hyperplasia 13 (26%) 13 (27%) 7 (14%) 9 (18%)
Parathyroid Gland (39) (40) (42) (39)
Cyst 1 (3%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88120-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 09/24/99
Route: DOSED FEED Time: 08:20:21
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 30 PPM 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pituitary Gland (49) (50) (49) (50)
Cyst 2 (4%) 1 (2%)
Pars Distalis, Hyperplasia, Focal 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Granuloma Sperm 2 (4%) 2 (4%) 2 (4%)
Hemorrhage 1 (2%) 1 (2%)
Preputial Gland (50) (50) (50) (50)
Atrophy 1 (2%)
Cyst 26 (52%) 23 (46%) 25 (50%) 11 (22%)
Inflammation, Chronic Active 31 (62%) 29 (58%) 23 (46%) 14 (28%)
Inflammation, Suppurative 6 (12%) 3 (6%) 2 (4%)
Prostate (50) (50) (50) (50)
Inflammation, Granulomatous 1 (2%)
Artery, Inflammation, Chronic 1 (2%)
Seminal Vesicle (50) (50) (50) (50)
Fibrosis, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%)
Artery, Inflammation, Chronic 1 (2%)
Testes (50) (50) (50) (50)
Fibrosis, Focal 1 (2%)
Germinal Epithelium, Atrophy 1 (2%) 1 (2%) 3 (6%) 4 (8%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Necrosis 1 (2%)
Lymph Node, Mandibular (46) (49) (48) (50)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 6 (12%) 4 (8%)
Hyperplasia, Plasma Cell 1 (2%)
Lymph Node, Mesenteric (48) (45) (47) (46)
Angiectasis 1 (2%)
Ectasia 1 (2%) 1 (2%)
Erythrophagocytosis 1 (2%) 2 (4%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%) 4 (9%)
Vein, Ectasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88120-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 09/24/99
Route: DOSED FEED Time: 08:20:21
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 30 PPM 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Spleen (50) (50) (50) (49)
Hematopoietic Cell Proliferation 17 (34%) 12 (24%) 9 (18%) 13 (27%)
Capsule, Inflammation, Acute 1 (2%)
Lymphoid Follicle, Atrophy 8 (16%) 2 (4%) 3 (6%) 8 (16%)
Lymphoid Follicle, Hyperplasia 1 (2%) 5 (10%) 7 (14%) 2 (4%)
Thymus (45) (47) (39) (44)
Atrophy 25 (56%) 35 (74%) 25 (64%) 20 (45%)
Cyst 4 (9%) 6 (13%) 6 (15%) 5 (11%)
Hyperplasia 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (50)
Ulcer 1 (2%)
Sebaceous Gland, Hyperplasia 1 (2%)
Subcutaneous Tissue, Edema 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrosis 1 (2%) 2 (4%)
Skeletal Muscle (1)
Degeneration, Focal 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Hemorrhage 1 (2%)
Cerebrum, Necrosis 1 (2%)
Peripheral Nerve (1)
Axon, Degeneration 1 (100%)
Spinal Cord (1)
Axon, Degeneration 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Erythrophagocytosis, Focal 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Inflammation, Chronic, Focal 1 (2%) 1 (2%)
Inflammation, Granulomatous 2 (4%) 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88120-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 09/24/99
Route: DOSED FEED Time: 08:20:21
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 30 PPM 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Alveolar Epithelium, Hyperplasia, Focal 2 (4%) 2 (4%) 4 (8%)
Bronchus, Foreign Body 1 (2%)
Bronchus, Inflammation, Suppurative 1 (2%)
Serosa, Inflammation, Chronic, Focal 1 (2%)
Vein, Mineralization 1 (2%)
Nose (50) (50) (50) (50)
Sinus, Inflammation, Chronic 1 (2%)
Sinus, Inflammation, Suppurative 2 (4%)
Turbinate, Inflammation, Suppurative 3 (6%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1)
Degeneration 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Infarct 1 (2%) 2 (4%) 1 (2%)
Metaplasia, Osseous 1 (2%)
Nephropathy 36 (72%) 44 (88%) 42 (84%) 36 (72%)
Artery, Inflammation, Chronic 1 (2%)
Pelvis, Inflammation, Chronic Active 1 (2%)
Pelvis, Transitional Epithelium,
Mineralization 1 (2%)
Renal Tubule, Cyst 1 (2%) 3 (6%) 1 (2%)
Renal Tubule, Necrosis, Acute 3 (6%)
Ureter (1)
Cyst 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
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