TDMS Study 88120-04 Pathology Tables
NTP Experiment-Test: 88120-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 09/24/99 Route: DOSED FEED Time: 08:28:04 CORE STUDY Facility: Battelle Columbus Laboratory Chemical CAS #: 80-07-9 Lock Date: 08/11/98 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 88120-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 09/24/99 Route: DOSED FEED Time: 08:28:04 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 PPM 30 PPM 100 PPM 300 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 50 50 50 50 Early Deaths Natural Death 5 9 6 4 Moribund Sacrifice 3 1 1 1 Survivors Terminal Sacrifice 42 40 43 45 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Esophagus (50) (49) (50) (50) Squamous Cell Papilloma 1 (2%) Gallbladder (49) (49) (50) (49) Intestine Small, Jejunum (50) (50) (50) (50) Leiomyosarcoma 1 (2%) Liver (50) (50) (50) (50) Hemangioma 1 (2%) Hepatocellular Carcinoma 3 (6%) 1 (2%) 2 (4%) 1 (2%) Hepatocellular Adenoma 4 (8%) 4 (8%) 6 (12%) 7 (14%) Hepatocellular Adenoma, Multiple 1 (2%) Histiocytic Sarcoma 2 (4%) 1 (2%) 2 (4%) Sarcoma, Metastatic, Skin 1 (2%) Mesentery (5) (2) (5) (5) Sarcoma NOS 1 (20%) 1 (20%) Pancreas (50) (49) (50) (50) Salivary Glands (49) (48) (50) (50) Stomach, Forestomach (50) (50) (50) (50) Squamous Cell Papilloma 1 (2%) Tongue (1) Epithelium, Squamous Cell Carcinoma 1 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (50) (50) (50) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (49) (50) (50) Histiocytic Sarcoma 1 (2%) Adrenal Medulla (50) (49) (50) (50) Pheochromocytoma Malignant 1 (2%) NTP Experiment-Test: 88120-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 09/24/99 Route: DOSED FEED Time: 08:28:04 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 PPM 30 PPM 100 PPM 300 PPM ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont Pheochromocytoma Benign 1 (2%) Islets, Pancreatic (50) (50) (50) (50) Carcinoma 1 (2%) Pituitary Gland (48) (46) (48) (48) Pars Distalis, Adenoma 3 (6%) 2 (4%) 6 (13%) 6 (13%) Pars Intermedia, Adenoma 1 (2%) 1 (2%) 1 (2%) Thyroid Gland (50) (49) (50) (50) Follicular Cell, Adenoma 2 (4%) 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (50) (48) (49) (48) Cystadenoma 2 (4%) 4 (8%) 2 (4%) Granulosa Cell Tumor Benign 1 (2%) Histiocytic Sarcoma 1 (2%) 2 (4%) Bilateral, Cystadenoma 1 (2%) Uterus (50) (50) (50) (50) Histiocytic Sarcoma 1 (2%) 2 (4%) Polyp Stromal 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (50) (50) (50) Hemangiosarcoma 1 (2%) Histiocytic Sarcoma 2 (4%) Lymph Node (3) (6) (4) (4) Bronchial, Histiocytic Sarcoma 1 (17%) Mediastinal, Carcinoma, Metastatic, Islets, Pancreatic 1 (33%) Mediastinal, Histiocytic Sarcoma 1 (17%) Renal, Histiocytic Sarcoma 1 (17%) Lymph Node, Mandibular (47) (47) (50) (50) Histiocytic Sarcoma 1 (2%) 1 (2%) Lymph Node, Mesenteric (50) (46) (49) (46) Histiocytic Sarcoma 1 (2%) Spleen (49) (49) (50) (50) Hemangiosarcoma 1 (2%) Histiocytic Sarcoma 1 (2%) Thymus (49) (48) (50) (50) ____________________________________________________________________________________________________________________________________ NTP Experiment-Test: 88120-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 09/24/99 Route: DOSED FEED Time: 08:28:04 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 PPM 30 PPM 100 PPM 300 PPM ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (50) (50) (50) (50) Carcinoma 1 (2%) 1 (2%) Skin (50) (50) (50) (50) Subcutaneous Tissue, Fibrosarcoma 1 (2%) Subcutaneous Tissue, Myxosarcoma 1 (2%) Subcutaneous Tissue, Sarcoma NOS 3 (6%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (50) (50) Osteosarcoma 1 (2%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (49) (50) (50) Histiocytic Sarcoma 1 (2%) Cranial Nerve, Schwannoma Malignant 1 (2%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (50) (50) (50) Alveolar/Bronchiolar Adenoma 4 (8%) 1 (2%) 2 (4%) Alveolar/Bronchiolar Adenoma, Multiple 1 (2%) Alveolar/Bronchiolar Carcinoma 2 (4%) 1 (2%) 2 (4%) Carcinoma, Metastatic, Islets, Pancreatic 1 (2%) Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) Histiocytic Sarcoma 1 (2%) 1 (2%) Osteosarcoma, Metastatic, Bone 1 (2%) Pheochromocytoma Malignant, Metastatic, Adrenal Cortex 1 (2%) Nose (50) (50) (50) (50) Trachea (50) (50) (50) (50) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (1) (3) (3) (1) Harderian Gland (3) (2) (2) (2) Adenoma 3 (100%) 2 (100%) 2 (100%) 1 (50%) Carcinoma 1 (50%) ____________________________________________________________________________________________________________________________________ NTP Experiment-Test: 88120-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 09/24/99 Route: DOSED FEED Time: 08:28:04 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 PPM 30 PPM 100 PPM 300 PPM ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (50) (50) Histiocytic Sarcoma 1 (2%) 1 (2%) Urinary Bladder (50) (50) (50) (50) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(50) *(50) *(50) *(50) Histiocytic Sarcoma 2 (4%) 1 (2%) 2 (4%) Lymphoma Malignant 6 (12%) 10 (20%) 5 (10%) 3 (6%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 5 NTP Experiment-Test: 88120-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 09/24/99 Route: DOSED FEED Time: 08:28:04 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 PPM 30 PPM 100 PPM 300 PPM ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 23 28 20 26 Total Primary Neoplasms 30 39 30 38 Total Animals with Benign Neoplasms 15 15 15 16 Total Benign Neoplasms 17 18 20 23 Total Animals with Malignant Neoplasms 12 18 9 14 Total Malignant Neoplasms 13 21 10 15 Total Animals with Metastatic Neoplasms 3 1 1 Total Metastatic Neoplasm 4 1 1 Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors NTP Experiment-Test: 88120-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 09/24/99 Route: DOSED FEED Time: 08:28:04 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 PPM 30 PPM 100 PPM 300 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 50 50 50 50 Early Deaths Natural Death 9 3 4 5 Moribund Sacrifice 1 2 2 3 Survivors Terminal Sacrifice 40 45 43 42 Natural Death 1 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Colon (50) (50) (50) (50) Mast Cell Tumor Malignant, Metastatic, Bone Marrow 1 (2%) Intestine Large, Cecum (50) (50) (50) (50) Carcinoma 1 (2%) Intestine Small, Duodenum (50) (50) (49) (50) Polyp Adenomatous 1 (2%) 2 (4%) Intestine Small, Jejunum (50) (50) (50) (50) Carcinoma 1 (2%) Liver (50) (50) (50) (50) Hemangiosarcoma 2 (4%) 1 (2%) Hepatocellular Carcinoma 8 (16%) 2 (4%) 4 (8%) 4 (8%) Hepatocellular Carcinoma, Multiple 1 (2%) 1 (2%) 1 (2%) Hepatocellular Adenoma 4 (8%) 8 (16%) 4 (8%) 9 (18%) Hepatocellular Adenoma, Multiple 2 (4%) 1 (2%) 1 (2%) Histiocytic Sarcoma 1 (2%) Mast Cell Tumor Malignant, Metastatic, Bone Marrow 1 (2%) Oral Mucosa (50) (50) (50) (50) Mast Cell Tumor Malignant, Metastatic, Bone Marrow 1 (2%) Salivary Glands (50) (50) (50) (50) Stomach, Forestomach (50) (50) (50) (50) Mast Cell Tumor Malignant, Metastatic, Bone Marrow 1 (2%) 1 (2%) Stomach, Glandular (50) (50) (50) (50) Mast Cell Tumor Malignant, Metastatic, Bone Marrow 1 (2%) Tongue (1) Squamous Cell Carcinoma 1 (100%) ____________________________________________________________________________________________________________________________________ NTP Experiment-Test: 88120-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 09/24/99 Route: DOSED FEED Time: 08:28:04 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 PPM 30 PPM 100 PPM 300 PPM ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (50) (50) (50) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (49) (50) (50) (50) Adenoma 1 (2%) Adrenal Medulla (49) (50) (50) (50) Islets, Pancreatic (50) (49) (49) (49) Mast Cell Tumor Malignant, Metastatic, Bone Marrow 1 (2%) Thyroid Gland (50) (50) (50) (49) Follicular Cell, Adenoma 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (50) (50) (50) (50) Histiocytic Sarcoma 1 (2%) Prostate (50) (50) (50) (50) Testes (50) (50) (50) (50) Interstitial Cell, Adenoma 1 (2%) 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (50) (50) (50) Hemangioma 1 (2%) Hemangiosarcoma 1 (2%) Mast Cell Tumor Malignant 1 (2%) 1 (2%) 1 (2%) Lymph Node (2) (1) (1) (1) Lymph Node, Mandibular (46) (49) (48) (50) Lymph Node, Mesenteric (48) (45) (47) (46) Mast Cell Tumor Malignant, Metastatic, Bone Marrow 1 (2%) Spleen (50) (50) (50) (49) Hemangiosarcoma 1 (2%) 1 (2%) 1 (2%) 1 (2%) Histiocytic Sarcoma 1 (2%) Mast Cell Tumor Malignant, Metastatic, Bone Marrow 1 (2%) Thymus (45) (47) (39) (44) NTP Experiment-Test: 88120-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 09/24/99 Route: DOSED FEED Time: 08:28:04 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 PPM 30 PPM 100 PPM 300 PPM ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (50) (50) (50) (50) Subcutaneous Tissue, Hemangiosarcoma 1 (2%) Subcutaneous Tissue, Mast Cell Tumor Malignant 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (50) (50) Meninges, Meningioma Malignant 1 (2%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (50) (50) (50) Alveolar/Bronchiolar Adenoma 3 (6%) 5 (10%) 3 (6%) Alveolar/Bronchiolar Adenoma, Multiple 3 (6%) 1 (2%) 1 (2%) 2 (4%) Alveolar/Bronchiolar Carcinoma 7 (14%) 5 (10%) 4 (8%) 2 (4%) Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%) Carcinoma, Metastatic, Harderian Gland 1 (2%) Hepatocellular Carcinoma, Metastatic, Liver 6 (12%) 1 (2%) 1 (2%) Nose (50) (50) (50) (50) Mast Cell Tumor Malignant, Metastatic, Bone Marrow 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Harderian Gland (5) (2) (2) (1) Adenoma 4 (80%) 1 (50%) 2 (100%) 1 (100%) Carcinoma 1 (50%) Bilateral, Adenoma 1 (20%) ____________________________________________________________________________________________________________________________________ NTP Experiment-Test: 88120-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 09/24/99 Route: DOSED FEED Time: 08:28:04 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 PPM 30 PPM 100 PPM 300 PPM ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (50) (50) Hemangiosarcoma 1 (2%) Histiocytic Sarcoma 1 (2%) Mast Cell Tumor Malignant, Metastatic, Bone Marrow 1 (2%) 1 (2%) Renal Tubule, Adenoma 1 (2%) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(50) *(50) *(50) *(50) Histiocytic Sarcoma 1 (2%) Lymphoma Malignant 3 (6%) 3 (6%) 2 (4%) 1 (2%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 10 NTP Experiment-Test: 88120-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 09/24/99 Route: DOSED FEED Time: 08:28:04 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 PPM 30 PPM 100 PPM 300 PPM ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 32 28 22 21 Total Primary Neoplasms 43 37 29 27 Total Animals with Benign Neoplasms 16 18 11 12 Total Benign Neoplasms 19 21 13 14 Total Animals with Malignant Neoplasms 21 16 12 11 Total Malignant Neoplasms 24 16 16 13 Total Animals with Metastatic Neoplasms 7 2 1 2 Total Metastatic Neoplasm 15 2 1 3 Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------ --multipart-boundary Content-type: text/plain Range: bytes 61639-61639/61639 --multipart-boundary--