TDMS Study 88120-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus P,P'-DICHLORODIPHENYL SULFONE DATE: 09/24/99
EXPERIMENT: 88120 TEST: 04 TIME: 08:35:44
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-55388 ROUTE: DOSED FEED NTP C#: 88120B
PATHOLOGIST: RYAN, MICHAEL CAS: 80-07-9
------------------------------------------------------------------------------------------------------------------------------------
CORE STUDY
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus P,P'-DICHLORODIPHENYL SULFONE DATE: 09/24/99
EXPERIMENT: 88120 TEST: 04 TIME: 08:35:44
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-55388 ROUTE: DOSED FEED NTP C#: 88120B
PATHOLOGIST: RYAN, MICHAEL CAS: 80-07-9
P,P'-DICHLORODIPHENYL SULFONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 0 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 30 550 603 631 649 661 666 691 693 732 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 30 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 5 CENSORED DEATHS 0 TERMINAL 45 |
| |
| UNCENSORED DEATHS |
| 61 565 652 712 718 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 6 CENSORED DEATHS 0 TERMINAL 44 |
| |
| UNCENSORED DEATHS |
| 15 406 413 513 649 705 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
P,P'-DICHLORODIPHENYL SULFONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 300 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 8 CENSORED DEATHS 0 TERMINAL 42 |
| |
| UNCENSORED DEATHS |
| 16 369 379 407 485 609 702 712 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
P,P'-DICHLORODIPHENYL SULFONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 733 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 98.0 98.0 98.0 98.0 98.0 98.0 98.0 94.0 88.0 80.0 |
| | |
| | |
|30 PPM | 98.0 98.0 98.0 98.0 98.0 98.0 98.0 96.0 94.0 90.0 |
| | |
| | |
|100 PPM | 98.0 98.0 98.0 98.0 94.0 94.0 92.0 92.0 90.0 88.0 |
| | |
| | |
|300 PPM | 98.0 98.0 98.0 98.0 92.0 90.0 90.0 90.0 88.0 84.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 30 PPM 100 PPM 300 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 80.0% 90.0% 88.0% 84.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=1.000 P=0.254N P=0.446N P=0.837N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 590.6 541.6 450.2 459.9 |
|NATURAL DEATHS (C) | (64.3) ( 123) ( 100) (80.1) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 704.5 713.9 699.1 689.3 |
|(STANDARD ERROR) | (14.8) (13.8) (17.2) (18.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
P,P'-DICHLORODIPHENYL SULFONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 734 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 8 CENSORED DEATHS 0 TERMINAL 42 |
| |
| UNCENSORED DEATHS |
| 491 580 600 631 636 657 705 711 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 30 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 0 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 512 512 550 592 605 616 667 690 694 731 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 7 CENSORED DEATHS 0 TERMINAL 43 |
| |
| UNCENSORED DEATHS |
| 586 652 683 702 709 711 732 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
P,P'-DICHLORODIPHENYL SULFONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 734 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 300 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 5 CENSORED DEATHS 0 TERMINAL 45 |
| |
| UNCENSORED DEATHS |
| 578 690 701 723 726 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
P,P'-DICHLORODIPHENYL SULFONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 734 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 734 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 94.0 88.0 84.0 |
| | |
| | |
|30 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 96.0 90.0 88.0 80.0 |
| | |
| | |
|100 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 98.0 96.0 86.0 |
| | |
| | |
|300 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 98.0 98.0 90.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 30 PPM 100 PPM 300 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 84.0% 80.0% 86.0% 90.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.258N P=0.769 P=0.924N P=0.507N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 626.4 616.9 682.1 683.6 |
|NATURAL DEATHS (C) | (25.2) (24.5) (18.6) (27.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 716.8 710.6 726.7 729.0 |
|(STANDARD ERROR) | ( 6.8) ( 8.2) ( 3.5) ( 3.3) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
P,P'-DICHLORODIPHENYL SULFONE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
30 PPM = 2
100 PPM = 3
300 PPM = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 3 1 2
|
|
|
98 + 3 1 2 4 3 1 2
|
|
|
96 + 4 4 33 1 2 1 2
|
|
|
P 94 + 4 3 3 1 1 2 2
E |
R |
C |
E 92 + 4 4 3 1 1 22
N |
T |
|
S 90 + 4 4 1 1 3 2 2
U |
R |
V |
I 88 + 4 11 3 3
V |
A |
L |
86 + 1 1 44
|
|
|
84 + 4 4
|
|
|
82 + 1 1
|
|
|
80 + 1
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 9 obs hidden.
P,P'-DICHLORODIPHENYL SULFONE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
30 PPM = 2
100 PPM = 3
300 PPM = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 1 2 43
|
|
|
98 + 1 13 3 4
|
|
|
96 + 2 2 1 1 3 34 4
|
|
|
P 94 + 2 21 1 3 3 4
E |
R |
C |
E 92 + 2 2 33
N |
T |
|
S 90 + 22 1 1 4 4
U |
R |
V |
I 88 + 2 1 2 13 3
V |
A |
L |
86 + 2 2 11 3
|
|
|
84 + 22 1 1
|
|
|
82 + 2 2
|
|
|
80 + 2
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 5 obs hidden.
--multipart-boundary
Content-type: text/plain
Range: bytes 28077-28077/28077
--multipart-boundary--