TDMS Study 88122-06 Pathology Tables
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
FINAL#1
Facility: Battelle Columbus Laboratory
Chemical CAS #: 37319-17-8
Lock Date: 06/01/00
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7|
DAY ON TEST | 0| 2| 2| 2| 2| 9| 2| 2| 2| 2| 5| 9| 3| 3| 3| 2| 2| 1| 3| 0| 3| 2| 2| 3| 3|
| 0| 9| 6| 9| 9| 6| 8| 9| 9| 9| 1| 6| 0| 0| 0| 9| 9| 9| 0| 6| 0| 9| 9| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + + + + + +|
Parasite Metazoan | X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X |
Eosinophilic Focus | X X X X |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Granulomatous | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Mixed Cell Focus | X X X X X X X X X X|
Bile Duct, Hyperplasia | 2 2 2 1 2 1|
Centrilobular, Fatty Change | 4 |
|__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 2 2 1 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 2 1 1 |
Acinus, Hyperplasia, Focal | 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parotid Gland, Atrophy, Focal | |
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7|
DAY ON TEST | 0| 2| 2| 2| 2| 9| 2| 2| 2| 2| 5| 9| 3| 3| 3| 2| 2| 1| 3| 0| 3| 2| 2| 3| 3|
| 0| 9| 6| 9| 9| 6| 8| 9| 9| 9| 1| 6| 0| 0| 0| 9| 9| 9| 0| 6| 0| 9| 9| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Parotid Gland, Hyperplasia, Focal | 1 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + |
Epithelium, Hyperplasia, Focal, | |
Squamous | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Degeneration | 1 2 2 1 1 1 1 2 1 2 1 1 3 2 1 1 2 1|
Myocardium, Inflammation, Chronic, | |
Focal | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 1 2 3 2 1 1 2 1 1 1|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 2 1|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + M + + + + + + + M|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | 1 1 1 1 2 1 2 1 1 2 1|
Hemorrhage | |
Pars Distalis, Hyperplasia, Focal | 1 2 2 1 2 3 1 1 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7|
DAY ON TEST | 0| 2| 2| 2| 2| 9| 2| 2| 2| 2| 5| 9| 3| 3| 3| 2| 2| 1| 3| 0| 3| 2| 2| 3| 3|
| 0| 9| 6| 9| 9| 6| 8| 9| 9| 9| 1| 6| 0| 0| 0| 9| 9| 9| 0| 6| 0| 9| 9| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 1 3 2 2 2 2 2 3 2 2 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2|
Fibrosis | 1 |
Hyperplasia, Focal | 2 2 2 |
Hyperplasia | |
Inflammation, Chronic | 1 2 1 1 |
Inflammation, Suppurative | |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic | 1 1 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + |
Deep Cervical, Infiltration Cellular,| |
Histiocyte | |
Mediastinal, Hyperplasia, Lymphoid | 1 1 |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | |
Mediastinal, Infiltration Cellular, | |
Histiocyte | |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M + M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7|
DAY ON TEST | 0| 2| 2| 2| 2| 9| 2| 2| 2| 2| 5| 9| 3| 3| 3| 2| 2| 1| 3| 0| 3| 2| 2| 3| 3|
| 0| 9| 6| 9| 9| 6| 8| 9| 9| 9| 1| 6| 0| 0| 0| 9| 9| 9| 0| 6| 0| 9| 9| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 |
Necrosis, Focal | 3 |
Lymphoid Follicle, Atrophy | 2 2 2 2 2 2 2 2 2 3 2 2 2 3|
|__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + M + + + + + + + + + + +|
Epithelial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 1 4 |
Hyperplasia | 1 |
Duct, Dilatation | 2 1 2 2 1 1 2 2 1 1 2 1 3 2 2 3 2|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 1 2 |
Cerebrum, Necrosis, Focal | 2 |
Hypothalamus, Compression | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | 2 |
Inflammation, Granulomatous, | |
Multifocal | 2 |
Metaplasia, Osseous | 1 |
Alveolar Epithelium, Hyperplasia, | |
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7|
DAY ON TEST | 0| 2| 2| 2| 2| 9| 2| 2| 2| 2| 5| 9| 3| 3| 3| 2| 2| 1| 3| 0| 3| 2| 2| 3| 3|
| 0| 9| 6| 9| 9| 6| 8| 9| 9| 9| 1| 6| 0| 0| 0| 9| 9| 9| 0| 6| 0| 9| 9| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Focal | 1 1 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Emphysema, Focal | |
Alveolus, Inflammation, Chronic | |
Active, Focal | 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 1 1 |
Nephropathy | 1 1 1 1 1 1 1 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 6
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 5| 7| 6| 6| 7| 7| 6| 4| 6| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 4| |
DAY ON TEST | 2| 3| 3| 2| 9| 5| 2| 2| 7| 2| 3| 9| 2| 7| 3| 0| 3| 2| 0| 2| 0| 2| 3| 2| 6| |
| 9| 0| 0| 2| 1| 9| 8| 1| 3| 9| 0| 0| 7| 8| 0| 7| 0| 9| 9| 9| 1| 9| 0| 9| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 2 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + A A + + + + + A + + + + + +| 46 |
Parasite Metazoan | X | 2 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Peyer's Patch, Hyperplasia, Lymphoid | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | | 1 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X | 39 |
Clear Cell Focus | X X | 8 |
Eosinophilic Focus | X X X X X X X X | 12 |
Hepatodiaphragmatic Nodule | X X X X X X X | 9 |
Inflammation, Granulomatous | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 36 1.0|
Mixed Cell Focus | X X X X X X X X X | 19 |
Bile Duct, Hyperplasia | 1 1 1 2 1 1 1 | 13 1.4|
Centrilobular, Fatty Change | | 1 4.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + | 8 |
Fat, Necrosis | 2 2 2 1 | 7 1.7|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 1 1| 7 1.1|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 5| 7| 6| 6| 7| 7| 6| 4| 6| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 4| |
DAY ON TEST | 2| 3| 3| 2| 9| 5| 2| 2| 7| 2| 3| 9| 2| 7| 3| 0| 3| 2| 0| 2| 0| 2| 3| 2| 6| |
| 9| 0| 0| 2| 1| 9| 8| 1| 3| 9| 0| 0| 7| 8| 0| 7| 0| 9| 9| 9| 1| 9| 0| 9| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Acinus, Hyperplasia, Focal | | 1 1.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parotid Gland, Atrophy, Focal | 1 1 | 2 1.0|
Parotid Gland, Hyperplasia, Focal | | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Tongue | | 1 |
Epithelium, Hyperplasia, Focal, | | |
Squamous | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myocardium, Degeneration | 1 1 1 2 1 1 2 2 1 1 2 2 2 2 1 1 1 1 1 1| 38 1.4|
Myocardium, Inflammation, Chronic, | | |
Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 2 1 1 1 1 2 1 1| 20 1.5|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 1 1 | 5 1.6|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 5| 7| 6| 6| 7| 7| 6| 4| 6| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 4| |
DAY ON TEST | 2| 3| 3| 2| 9| 5| 2| 2| 7| 2| 3| 9| 2| 7| 3| 0| 3| 2| 0| 2| 0| 2| 3| 2| 6| |
| 9| 0| 0| 2| 1| 9| 8| 1| 3| 9| 0| 0| 7| 8| 0| 7| 0| 9| 9| 9| 1| 9| 0| 9| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Cyst | 2 1 1 1 1 1 1 1 1 | 20 1.2|
Hemorrhage | 2 | 1 2.0|
Pars Distalis, Hyperplasia, Focal | 3 1 1 2 3 3 1 2 | 16 1.8|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 2 1 1 2 1 2 2 3 2 2 3 4 1 4 1 2 2 2 1| 33 2.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 1 2 | 4 1.8|
Fibrosis | | 1 1.0|
Hyperplasia, Focal | 3 2 | 5 2.2|
Hyperplasia | 3 | 1 3.0|
Inflammation, Chronic | 1 1 1 | 7 1.1|
Inflammation, Suppurative | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 1 3 1 | 4 2.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Endometrium, Hyperplasia, Cystic | 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 5| 7| 6| 6| 7| 7| 6| 4| 6| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 4| |
DAY ON TEST | 2| 3| 3| 2| 9| 5| 2| 2| 7| 2| 3| 9| 2| 7| 3| 0| 3| 2| 0| 2| 0| 2| 3| 2| 6| |
| 9| 0| 0| 2| 1| 9| 8| 1| 3| 9| 0| 0| 7| 8| 0| 7| 0| 9| 9| 9| 1| 9| 0| 9| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Lymph Node | + + + + | 7 |
Deep Cervical, Infiltration Cellular,| | |
Histiocyte | 1 | 1 1.0|
Mediastinal, Hyperplasia, Lymphoid | | 2 1.0|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | 3 | 1 3.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M M M M M M M M M M M M M M M M M M M M + M M M| 3 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 1 1 1 1 | 6 1.0|
Necrosis, Focal | | 1 3.0|
Lymphoid Follicle, Atrophy | 3 2 2 2 2 2 2 2 2 3 2 2 2 2 1 2 3 2 2 2 2| 35 2.1|
|__________________________________________________________________________|____________|
Thymus | + + M + + M + + + + + M + + + + + + + + + + + + +| 45 |
Epithelial Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 1 1 1| 6 1.5|
Hyperplasia | 2 | 2 1.5|
Duct, Dilatation | 2 1 2 1 1 1 1 3 1 3 2 2| 29 1.7|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 5| 7| 6| 6| 7| 7| 6| 4| 6| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 4| |
DAY ON TEST | 2| 3| 3| 2| 9| 5| 2| 2| 7| 2| 3| 9| 2| 7| 3| 0| 3| 2| 0| 2| 0| 2| 3| 2| 6| |
| 9| 0| 0| 2| 1| 9| 8| 1| 3| 9| 0| 0| 7| 8| 0| 7| 0| 9| 9| 9| 1| 9| 0| 9| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrocephalus | 3 1 3 3 3 4| 8 2.5|
Cerebrum, Necrosis, Focal | | 1 2.0|
Hypothalamus, Compression | 1 4 3 4| 5 2.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 2 2 2 | 5 2.0|
Hemorrhage | 3 | 2 2.5|
Inflammation, Granulomatous, | | |
Multifocal | | 1 2.0|
Metaplasia, Osseous | 1 | 2 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 | 3 1.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Alveolus, Emphysema, Focal | 2 | 1 2.0|
Alveolus, Inflammation, Chronic | | |
Active, Focal | 1 | 2 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 2 1 | 6 1.2|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | | 2 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 5| 7| 6| 6| 7| 7| 6| 4| 6| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 4| |
DAY ON TEST | 2| 3| 3| 2| 9| 5| 2| 2| 7| 2| 3| 9| 2| 7| 3| 0| 3| 2| 0| 2| 0| 2| 3| 2| 6| |
| 9| 0| 0| 2| 1| 9| 8| 1| 3| 9| 0| 0| 7| 8| 0| 7| 0| 9| 9| 9| 1| 9| 0| 9| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Nephropathy | 1 1 1 1 1 1 1 1| 16 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 5| 7| 5| 3| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 2| 1| 2| 2| 2| 7| 2| 1| 2| 2| 2| 2| 1| 3| 2| 8| 3| 3| 3| 3| 2| 2| 3|
| 0| 9| 9| 4| 8| 9| 8| 0| 9| 6| 2| 9| 9| 8| 5| 9| 9| 9| 3| 0| 0| 0| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
28 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + + + + + A + + A A + + + + + +|
Myxomatous Change | |
Parasite Metazoan | X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X |
Eosinophilic Focus | X X |
Hepatodiaphragmatic Nodule | X X X X |
Inflammation, Granulomatous | 1 1 1 1 1 1 1 1 1 1 1 2 1|
Mixed Cell Focus | X X X X X |
Regeneration | 3 |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 |
Centrilobular, Fatty Change | 4 3 |
|__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 2 2 3 |
|__________________________________________________________________________|
Oral Mucosa | + |
Pharyngeal, Hyperplasia, Squamous | 4 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 3 2 |
Acinus, Hyperplasia, Focal | |
__________________________________________|__________________________________________________________________________|
Page 13
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 5| 7| 5| 3| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 2| 1| 2| 2| 2| 7| 2| 1| 2| 2| 2| 2| 1| 3| 2| 8| 3| 3| 3| 3| 2| 2| 3|
| 0| 9| 9| 4| 8| 9| 8| 0| 9| 6| 2| 9| 9| 8| 5| 9| 9| 9| 3| 0| 0| 0| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
28 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parotid Gland, Atrophy, Focal | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
Epithelium, Ectasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | 4 |
Myocardium, Degeneration | 1 2 1 1 1 2 1 1 1 1 2 1 2 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 1 1 1 1 1 1 2 2 1 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 1 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Parathyroid Gland | M + + + + + + M + + + + + + + + M + + M + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 |
Cyst | 2 2 1 1 1 2 1 3 2 1 1 1 |
Pars Distalis, Hyperplasia, Focal | 2 1 1 3 2 2 1 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 4 2 4 2 2 4 4 2 3 3 2 1 1 2 4 4 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
__________________________________________|__________________________________________________________________________|
Page 14
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 5| 7| 5| 3| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 2| 1| 2| 2| 2| 7| 2| 1| 2| 2| 2| 2| 1| 3| 2| 8| 3| 3| 3| 3| 2| 2| 3|
| 0| 9| 9| 4| 8| 9| 8| 0| 9| 6| 2| 9| 9| 8| 5| 9| 9| 9| 3| 0| 0| 0| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
28 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Focal | 2 |
Inflammation, Chronic | 1 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 3 2 |
|__________________________________________________________________________|
Oviduct | |
Cyst | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
Endometrium, Hyperplasia, Cystic | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + |
Deep Cervical, Hyperplasia, Lymphoid | 2 |
Mediastinal, Ectasia | 2 2 |
Mediastinal, Hemorrhage | 2 1 2 |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Necrosis, Lymphoid | 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M + + + M M M M M + M + M M M + +|
Infiltration Cellular, Histiocyte | 3 |
Necrosis, Lymphoid | 3 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 2|
Hyperplasia, Lymphohistiocytic | |
__________________________________________|__________________________________________________________________________|
Page 15
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 5| 7| 5| 3| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 2| 1| 2| 2| 2| 7| 2| 1| 2| 2| 2| 2| 1| 3| 2| 8| 3| 3| 3| 3| 2| 2| 3|
| 0| 9| 9| 4| 8| 9| 8| 0| 9| 6| 2| 9| 9| 8| 5| 9| 9| 9| 3| 0| 0| 0| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
28 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Lymphoid Follicle, Atrophy | 2 1 2 4 2 2 2 2 2 2 2 2 2 2 2|
|__________________________________________________________________________|
Thymus | + + M + + + + M + + + + + + M + M + + + M + M + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 1 |
Duct, Dilatation | 1 2 1 1 2 1 1 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Pigmentation, | |
Hemosiderin | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 3 2 2|
Hypothalamus, Compression | 3|
Medulla, Compression | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 1 |
Alveolus, Inflammation, Acute | 2 |
Alveolus, Inflammation, Chronic | |
Active, Focal | 1 1 1 2 1 2 2 1 1 1 2 1 2|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 16
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 5| 7| 5| 3| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 2| 1| 2| 2| 2| 7| 2| 1| 2| 2| 2| 2| 1| 3| 2| 8| 3| 3| 3| 3| 2| 2| 3|
| 0| 9| 9| 4| 8| 9| 8| 0| 9| 6| 2| 9| 9| 8| 5| 9| 9| 9| 3| 0| 0| 0| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
28 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Inflammation, Chronic | 1 1 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Peritracheal Tissue, Hemorrhage | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + |
Cataract | |
Degeneration | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal, Suppurative | 2 |
Nephropathy | 1 1 1 1 1 1 1|
Renal Tubule, Cyst | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 17
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 5| 7| 5| 4| 7| 1| 7| 7| 5| 7| 7| 6| 6| 7| |
DAY ON TEST | 2| 3| 2| 3| 3| 2| 2| 7| 5| 2| 2| 1| 1| 2| 7| 2| 9| 1| 2| 9| 2| 3| 7| 7| 3| |
| 8| 0| 9| 0| 0| 9| 9| 8| 3| 8| 9| 0| 6| 6| 4| 9| 7| 9| 8| 4| 9| 0| 7| 8| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
28 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X| 3 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + A + + + + A + + + + + + + + A + +| 43 |
Myxomatous Change | 1 | 1 1.0|
Parasite Metazoan | X X | 3 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X| 35 |
Clear Cell Focus | | 4 |
Eosinophilic Focus | X X X X X X X X X X | 12 |
Hepatodiaphragmatic Nodule | X X X X| 8 |
Inflammation, Granulomatous | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1| 31 1.1|
Mixed Cell Focus | X X X X X X X| 12 |
Regeneration | | 1 3.0|
Bile Duct, Hyperplasia | 1 1 1 2 1 1 1 | 14 1.1|
Centrilobular, Fatty Change | | 2 3.5|
|__________________________________________________________________________|____________|
Mesentery | + | 4 |
Fat, Necrosis | 1 | 4 2.0|
|__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
Pharyngeal, Hyperplasia, Squamous | | 1 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 5| 7| 5| 4| 7| 1| 7| 7| 5| 7| 7| 6| 6| 7| |
DAY ON TEST | 2| 3| 2| 3| 3| 2| 2| 7| 5| 2| 2| 1| 1| 2| 7| 2| 9| 1| 2| 9| 2| 3| 7| 7| 3| |
| 8| 0| 9| 0| 0| 9| 9| 8| 3| 8| 9| 0| 6| 6| 4| 9| 7| 9| 8| 4| 9| 0| 7| 8| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
28 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 3 1 1 1 3 1 1 1| 12 1.7|
Acinus, Hyperplasia, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parotid Gland, Atrophy, Focal | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 1.0|
Epithelium, Ectasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrium, Thrombosis | | 1 4.0|
Myocardium, Degeneration | 1 1 1 1 1 2 1 1 2 2 1 3 1 1| 30 1.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 1 2 3 1 1 1| 17 1.3|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | | 2 1.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + + + + M + + + + + + + + + + +| 44 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 5| 7| 5| 4| 7| 1| 7| 7| 5| 7| 7| 6| 6| 7| |
DAY ON TEST | 2| 3| 2| 3| 3| 2| 2| 7| 5| 2| 2| 1| 1| 2| 7| 2| 9| 1| 2| 9| 2| 3| 7| 7| 3| |
| 8| 0| 9| 0| 0| 9| 9| 8| 3| 8| 9| 0| 6| 6| 4| 9| 7| 9| 8| 4| 9| 0| 7| 8| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
28 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 2 2.5|
Cyst | 2 1 2 1 1 1 1 1 2 | 21 1.4|
Pars Distalis, Hyperplasia, Focal | 1 1 1 2 2 1 2 1| 15 1.5|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 2 2 2 3 2 2 1 3 4 1 3 1 1 1 2 2 1 1 1| 38 2.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 2 3 2 | 4 2.5|
Hyperplasia, Focal | 1 2 | 3 1.7|
Inflammation, Chronic | 1 1 1 2 1 2 1 1 1| 10 1.2|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 1 | 5 2.2|
|__________________________________________________________________________|____________|
Oviduct | + | 1 |
Cyst | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 4 | 1 4.0|
Endometrium, Hyperplasia, Cystic | 2 2 2 1 | 5 1.6|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 1 | 1 1.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 5| 7| 5| 4| 7| 1| 7| 7| 5| 7| 7| 6| 6| 7| |
DAY ON TEST | 2| 3| 2| 3| 3| 2| 2| 7| 5| 2| 2| 1| 1| 2| 7| 2| 9| 1| 2| 9| 2| 3| 7| 7| 3| |
| 8| 0| 9| 0| 0| 9| 9| 8| 3| 8| 9| 0| 6| 6| 4| 9| 7| 9| 8| 4| 9| 0| 7| 8| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
28 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Lymph Node | + + + + + + + | 19 |
Deep Cervical, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Ectasia | | 2 2.0|
Mediastinal, Hemorrhage | | 3 1.7|
Mediastinal, Hyperplasia, Lymphoid | 2 2 | 3 2.0|
Mediastinal, Necrosis, Lymphoid | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M M + M M M M M M M M M M M| 8 |
Infiltration Cellular, Histiocyte | | 1 3.0|
Necrosis, Lymphoid | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Histiocyte | 1 2 | 3 1.3|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | | 2 1.5|
Hyperplasia, Lymphohistiocytic | 2 | 1 2.0|
Lymphoid Follicle, Atrophy | 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 | 32 2.1|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + M + + + + + + + + + + + + + +| 41 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 1 | 3 1.3|
Duct, Dilatation | 1 1 1 1 1 1 3 | 15 1.3|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Pigmentation, | | |
Hemosiderin | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 5| 7| 5| 4| 7| 1| 7| 7| 5| 7| 7| 6| 6| 7| |
DAY ON TEST | 2| 3| 2| 3| 3| 2| 2| 7| 5| 2| 2| 1| 1| 2| 7| 2| 9| 1| 2| 9| 2| 3| 7| 7| 3| |
| 8| 0| 9| 0| 0| 9| 9| 8| 3| 8| 9| 0| 6| 6| 4| 9| 7| 9| 8| 4| 9| 0| 7| 8| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
28 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
Osteopetrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrocephalus | 3 2 3 | 6 2.5|
Hypothalamus, Compression | 4 4 | 3 3.7|
Medulla, Compression | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 2 | 3 2.3|
Hemorrhage | | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 1 | 4 1.0|
Alveolus, Inflammation, Acute | | 1 2.0|
Alveolus, Inflammation, Chronic | | |
Active, Focal | 2 1 1 1 2 1 1 1 2 1 1 1| 25 1.3|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 | 3 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 1 2.0|
Peritracheal Tissue, Hemorrhage | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + | 3 |
Cataract | 3 | 1 3.0|
Degeneration | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 5| 7| 5| 4| 7| 1| 7| 7| 5| 7| 7| 6| 6| 7| |
DAY ON TEST | 2| 3| 2| 3| 3| 2| 2| 7| 5| 2| 2| 1| 1| 2| 7| 2| 9| 1| 2| 9| 2| 3| 7| 7| 3| |
| 8| 0| 9| 0| 0| 9| 9| 8| 3| 8| 9| 0| 6| 6| 4| 9| 7| 9| 8| 4| 9| 0| 7| 8| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
28 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Focal, Suppurative | | 1 2.0|
Nephropathy | 1 1 1 1 1 1 | 13 1.0|
Renal Tubule, Cyst | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 4| 7| 6| 7| 7| 6| 7| 3| 4| 7| 7| 7| 4| 6| 6| 7| 7| 7| 7| 5| 7| 1| 7| 6| 7|
DAY ON TEST | 9| 2| 8| 2| 3| 6| 3| 7| 7| 2| 3| 2| 8| 9| 7| 2| 2| 2| 2| 5| 3| 1| 3| 1| 2|
| 1| 8| 5| 8| 0| 7| 0| 5| 4| 8| 0| 8| 3| 1| 3| 8| 8| 8| 3| 9| 0| 1| 0| 4| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
84 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + A + + + + + + + + + + + + + A + A +|
Inflammation, Chronic | |
Myxomatous Change | 1 1 2 1 1 1 1 1 |
Parasite Metazoan | |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X |
Eosinophilic Focus | X X X X |
Fibrosis, Focal | 1 |
Hepatodiaphragmatic Nodule | X X X X X X X|
Inflammation, Granulomatous | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 |
Mixed Cell Focus | X X X X |
Regeneration | 2|
Tension Lipidosis | |
Bile Duct, Hyperplasia | 2 1 1 1 1 1|
Bile Duct, Inflammation | 1 |
|__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 2 3 3 |
|__________________________________________________________________________|
Oral Mucosa | |
Cyst | |
__________________________________________|__________________________________________________________________________|
Page 24
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 4| 7| 6| 7| 7| 6| 7| 3| 4| 7| 7| 7| 4| 6| 6| 7| 7| 7| 7| 5| 7| 1| 7| 6| 7|
DAY ON TEST | 9| 2| 8| 2| 3| 6| 3| 7| 7| 2| 3| 2| 8| 9| 7| 2| 2| 2| 2| 5| 3| 1| 3| 1| 2|
| 1| 8| 5| 8| 0| 7| 0| 5| 4| 8| 0| 8| 3| 1| 3| 8| 8| 8| 3| 9| 0| 1| 0| 4| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
84 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 1 1 1 1 1 2|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Inflammation, Chronic | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Degeneration | 1 2 2 1 1 1 1 1 1 2 2 1 2 2 2 2 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 1 1 1 1 1 3 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 3 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + + M + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Cyst | 1 1 1 1 1 1 1 2 1 1|
Pars Distalis, Hyperplasia, Focal | 1 1 1 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 25
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 4| 7| 6| 7| 7| 6| 7| 3| 4| 7| 7| 7| 4| 6| 6| 7| 7| 7| 7| 5| 7| 1| 7| 6| 7|
DAY ON TEST | 9| 2| 8| 2| 3| 6| 3| 7| 7| 2| 3| 2| 8| 9| 7| 2| 2| 2| 2| 5| 3| 1| 3| 1| 2|
| 1| 8| 5| 8| 0| 7| 0| 5| 4| 8| 0| 8| 3| 1| 3| 8| 8| 8| 3| 9| 0| 1| 0| 4| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
84 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Hemorrhage | 2 |
C-Cell, Hyperplasia | 3 4 2 2 2 2 1 1 2 2 2 2 3 3 2 2 2 1 2|
Follicle, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 1 2 1|
Hyperplasia, Focal | 2 |
Inflammation, Chronic | 2 2 1 1 1 |
Inflammation, Suppurative | |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 2 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic | 1 |
Endometrium, Inflammation, Chronic | |
|__________________________________________________________________________|
Vagina | + |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
|__________________________________________________________________________|
Lymph Node | + + + + + + |
Mediastinal, Ectasia | 2 |
Mediastinal, Hemorrhage | 1 |
Mediastinal, Hyperplasia, Lymphoid | 1 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M + M M M M M M M M M M M M M|
__________________________________________|__________________________________________________________________________|
Page 26
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 4| 7| 6| 7| 7| 6| 7| 3| 4| 7| 7| 7| 4| 6| 6| 7| 7| 7| 7| 5| 7| 1| 7| 6| 7|
DAY ON TEST | 9| 2| 8| 2| 3| 6| 3| 7| 7| 2| 3| 2| 8| 9| 7| 2| 2| 2| 2| 5| 3| 1| 3| 1| 2|
| 1| 8| 5| 8| 0| 7| 0| 5| 4| 8| 0| 8| 3| 1| 3| 8| 8| 8| 3| 9| 0| 1| 0| 4| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
84 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | 1 2 2 1 1 1 1 1 2 1 1 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 |
Hemorrhage | |
Hyperplasia, Lymphohistiocytic | 3 2 |
Lymphoid Follicle, Atrophy | 3 2 2 2 2 1 2 2 2 3 2 2 2 2 3|
|__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 |
Duct, Dilatation | 2 1 1 1 1 1 2 1 2 1 1 2|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 1 1 2 2|
Cerebrum, Degeneration, Focal | |
Cerebrum, Gliosis, Focal | |
Hypothalamus, Compression | 2 |
|__________________________________________________________________________|
Peripheral Nerve | |
|__________________________________________________________________________|
Spinal Cord | |
__________________________________________|__________________________________________________________________________|
Page 27
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 4| 7| 6| 7| 7| 6| 7| 3| 4| 7| 7| 7| 4| 6| 6| 7| 7| 7| 7| 5| 7| 1| 7| 6| 7|
DAY ON TEST | 9| 2| 8| 2| 3| 6| 3| 7| 7| 2| 3| 2| 8| 9| 7| 2| 2| 2| 2| 5| 3| 1| 3| 1| 2|
| 1| 8| 5| 8| 0| 7| 0| 5| 4| 8| 0| 8| 3| 1| 3| 8| 8| 8| 3| 9| 0| 1| 0| 4| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
84 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 2 |
Inflammation, Chronic Active, Focal | 1 |
Metaplasia, Osseous | 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 1 |
Alveolus, Inflammation, Chronic | |
Active, Focal | 1 2 3 1 2 1 2 1 2 1 2 1 1 2|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 1 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + |
Cataract | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 1 1 1 1 1 1 1|
Pelvis, Inflammation, Suppurative | 2 |
Renal Tubule, Pigmentation, | |
Lipofuscin | 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 28
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 6| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 5| 7| 2| 4| 4| 2| 0| 6| 1| 3| 1| 2| 2| 1| 3| 6| 3| 2| 2| 2| 3| 2| 2| 2| 3| |
| 3| 8| 8| 5| 5| 9| 5| 4| 1| 0| 5| 8| 8| 3| 0| 7| 0| 9| 9| 9| 0| 9| 9| 9| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
84 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 3 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A + + + A + + + + + + + + + + + + + + + + +| 44 |
Inflammation, Chronic | 2 | 1 2.0|
Myxomatous Change | 1 1 1 1 | 12 1.1|
Parasite Metazoan | X | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 2 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X| 40 |
Clear Cell Focus | X X X X X X | 8 |
Eosinophilic Focus | X X X X X X X X X X | 14 |
Fibrosis, Focal | | 1 1.0|
Hepatodiaphragmatic Nodule | X X X X | 11 |
Inflammation, Granulomatous | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 37 1.1|
Mixed Cell Focus | X X X X X X | 10 |
Regeneration | | 1 2.0|
Tension Lipidosis | X | 1 |
Bile Duct, Hyperplasia | 1 2 2 1 1| 11 1.3|
Bile Duct, Inflammation | | 1 1.0|
|__________________________________________________________________________|____________|
Mesentery | + + + | 6 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 6| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 5| 7| 2| 4| 4| 2| 0| 6| 1| 3| 1| 2| 2| 1| 3| 6| 3| 2| 2| 2| 3| 2| 2| 2| 3| |
| 3| 8| 8| 5| 5| 9| 5| 4| 1| 0| 5| 8| 8| 3| 0| 7| 0| 9| 9| 9| 0| 9| 9| 9| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
84 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Fat, Necrosis | 2 2 3 | 6 2.5|
|__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
Cyst | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 1 1 | 11 1.1|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Inflammation, Chronic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myocardium, Degeneration | 1 1 1 2 1 2 1 1 3 1 1 1 1 1| 31 1.4|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 2 1 1 2 4 1 1 1 1 | 17 1.4|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 1 3 | 4 2.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 6| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 5| 7| 2| 4| 4| 2| 0| 6| 1| 3| 1| 2| 2| 1| 3| 6| 3| 2| 2| 2| 3| 2| 2| 2| 3| |
| 3| 8| 8| 5| 5| 9| 5| 4| 1| 0| 5| 8| 8| 3| 0| 7| 0| 9| 9| 9| 0| 9| 9| 9| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
84 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Parathyroid Gland | + M + + + + + + + + + + + M + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 2 1.5|
Cyst | 1 1 1 1 1 1 1 1| 18 1.1|
Pars Distalis, Hyperplasia, Focal | 2 1 2 2 1 1 1 | 10 1.3|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
C-Cell, Hyperplasia | 2 2 1 4 2 4 2 2 1 2 2 2 2 2 2| 34 2.1|
Follicle, Hyperplasia | 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 4 1.5|
Hyperplasia, Focal | 1 | 2 1.5|
Inflammation, Chronic | 2 1 1 1 1 1 | 11 1.3|
Inflammation, Suppurative | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 3 1 2 3 | 7 2.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Endometrium, Hyperplasia, Cystic | 1 2 | 3 1.3|
Endometrium, Inflammation, Chronic | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Vagina | + | 2 |
Hyperplasia | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 6| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 5| 7| 2| 4| 4| 2| 0| 6| 1| 3| 1| 2| 2| 1| 3| 6| 3| 2| 2| 2| 3| 2| 2| 2| 3| |
| 3| 8| 8| 5| 5| 9| 5| 4| 1| 0| 5| 8| 8| 3| 0| 7| 0| 9| 9| 9| 0| 9| 9| 9| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
84 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 14 |
Mediastinal, Ectasia | 2 2 | 3 2.0|
Mediastinal, Hemorrhage | 2 | 2 1.5|
Mediastinal, Hyperplasia, Lymphoid | 2 2 | 3 1.7|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | 2 2 1 | 4 1.8|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M + M M M M M M + M M M M M M M M M M M M| 3 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 2 1 | 2 1.5|
Infiltration Cellular, Histiocyte | 1 1 2 1 2 2 2 2 1 1 1 1 1 2 1 1| 27 1.3|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 1 3 | 4 2.0|
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Lymphohistiocytic | | 2 2.5|
Lymphoid Follicle, Atrophy | 2 2 3 2 2 2 2 2 2 4 2 3 1 2 2 2 | 31 2.2|
|__________________________________________________________________________|____________|
Thymus | M + + + + + + + M + M + + + + + + + + + + + + + +| 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 1 | 3 1.7|
Duct, Dilatation | 2 1 2 2 3 1 1 1 | 20 1.5|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 6| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 5| 7| 2| 4| 4| 2| 0| 6| 1| 3| 1| 2| 2| 1| 3| 6| 3| 2| 2| 2| 3| 2| 2| 2| 3| |
| 3| 8| 8| 5| 5| 9| 5| 4| 1| 0| 5| 8| 8| 3| 0| 7| 0| 9| 9| 9| 0| 9| 9| 9| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
84 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrocephalus | 2 1 3 3 | 8 1.9|
Cerebrum, Degeneration, Focal | 1| 1 1.0|
Cerebrum, Gliosis, Focal | 2| 1 2.0|
Hypothalamus, Compression | 3 4 2 4 | 5 3.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
|__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 2.0|
Hemorrhage | 3 | 1 3.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
Inflammation, Chronic Active, Focal | | 1 1.0|
Metaplasia, Osseous | | 1 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 1 1| 5 1.2|
Alveolus, Inflammation, Chronic | | |
Active, Focal | 2 2 1 1 1 3 2 3 1 1 1 1 1 | 27 1.6|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 1 | 7 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 6| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 5| 7| 2| 4| 4| 2| 0| 6| 1| 3| 1| 2| 2| 1| 3| 6| 3| 2| 2| 2| 3| 2| 2| 2| 3| |
| 3| 8| 8| 5| 5| 9| 5| 4| 1| 0| 5| 8| 8| 3| 0| 7| 0| 9| 9| 9| 0| 9| 9| 9| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
84 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | | 1 |
Cataract | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy | 1 1 | 11 1.0|
Pelvis, Inflammation, Suppurative | | 1 2.0|
Renal Tubule, Pigmentation, | | |
Lipofuscin | | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 1| 2| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 5| 7| 6| 7| 7|
DAY ON TEST | 2| 3| 2| 1| 1| 5| 7| 2| 2| 2| 2| 3| 3| 0| 2| 2| 3| 2| 2| 3| 2| 2| 0| 3| 2|
| 9| 0| 8| 1| 6| 1| 2| 8| 8| 7| 8| 0| 0| 6| 4| 8| 0| 9| 9| 0| 5| 9| 3| 0| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
252 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Inflammation, Chronic | 2 |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + A A + A + + + + + + + A + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 2 1 1 1 1 1 |
Inflammation, Acute, Focal | |
Inflammation, Chronic | 1 |
Myxomatous Change | 2 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 2 |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X|
Eosinophilic Focus | X X X X X X X X X |
Hepatodiaphragmatic Nodule | X X X X X X X |
Inflammation, Granulomatous | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 1 1 1 1|
Mixed Cell Focus | X X X X X|
Necrosis, Focal | |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 |
|__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 2 3 2 1 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 1 1 1 1 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 35
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 1| 2| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 5| 7| 6| 7| 7|
DAY ON TEST | 2| 3| 2| 1| 1| 5| 7| 2| 2| 2| 2| 3| 3| 0| 2| 2| 3| 2| 2| 3| 2| 2| 0| 3| 2|
| 9| 0| 8| 1| 6| 1| 2| 8| 8| 7| 8| 0| 0| 6| 4| 8| 0| 9| 9| 0| 5| 9| 3| 0| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
252 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parotid Gland, Atrophy, Diffuse | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 1 |
Epithelium, Hyperplasia, Squamous | |
Epithelium, Inflammation, Focal, | |
Suppurative | 1 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 1 |
Mineralization | |
Pigmentation, Hemosiderin | |
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Inflammation, Chronic | 2 |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Hyperplasia, Focal | 2 |
Myocardium, Degeneration | 1 2 1 1 1 1 2 1 2 2 1 2 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 1 1 1 1 1 1 2 1 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 1 1 |
Necrosis | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 36
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 1| 2| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 5| 7| 6| 7| 7|
DAY ON TEST | 2| 3| 2| 1| 1| 5| 7| 2| 2| 2| 2| 3| 3| 0| 2| 2| 3| 2| 2| 3| 2| 2| 0| 3| 2|
| 9| 0| 8| 1| 6| 1| 2| 8| 8| 7| 8| 0| 0| 6| 4| 8| 0| 9| 9| 0| 5| 9| 3| 0| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
252 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 3 |
Cyst | 1 1 1 1 1 2 2 1 1 2|
Pars Distalis, Hyperplasia, Focal | 2 2 1 3 2 1 1|
Pars Distalis, Mineralization | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
C-Cell, Hyperplasia | 2 1 1 1 2 2 2 2 1 4 2 4 2 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 3 |
Hyperplasia, Focal | 1 2 |
Inflammation, Chronic | 2 1 1 1 |
Inflammation, Suppurative | 1|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 3 3 2|
Inflammation, Granulomatous | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
Cervix, Endometrium, Hyperplasia | |
Endometrium, Hyperplasia, Cystic | 1 |
|__________________________________________________________________________|
Vagina | |
Infiltration Cellular, | |
Polymorphonuclear | |
Epithelium, Vacuolization Cytoplasmic| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 37
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 1| 2| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 5| 7| 6| 7| 7|
DAY ON TEST | 2| 3| 2| 1| 1| 5| 7| 2| 2| 2| 2| 3| 3| 0| 2| 2| 3| 2| 2| 3| 2| 2| 0| 3| 2|
| 9| 0| 8| 1| 6| 1| 2| 8| 8| 7| 8| 0| 0| 6| 4| 8| 0| 9| 9| 0| 5| 9| 3| 0| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
252 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Lymph Node | + + + + + + |
Deep Cervical, Hemorrhage | 2 |
Deep Cervical, Hyperplasia, Lymphoid | 2 |
Mediastinal, Congestion | |
Mediastinal, Ectasia | |
Mediastinal, Hemorrhage | 1 2 |
Mediastinal, Hyperplasia, Lymphoid | 1 2 1 |
Mediastinal, Infiltration Cellular, | |
Mast Cell | 3 |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | 2 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 3 |
Pancreatic, Pigmentation, Hemosiderin| 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M + M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | 2 2 1 2 2 2 2 2 1 1 1 1 1 1 1 2 1 2 1 1 2 3 1|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphohistiocytic | 4 3 |
Lymphoid Follicle, Atrophy | 4 3 2 2 2 2 2 2 3 1 2|
Lymphoid Follicle, Hyperplasia | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + M + + + + + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Duct, Dilatation | 1 2 3 1 2 2 2 1 1 1 4 1 1 1|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 38
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 1| 2| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 5| 7| 6| 7| 7|
DAY ON TEST | 2| 3| 2| 1| 1| 5| 7| 2| 2| 2| 2| 3| 3| 0| 2| 2| 3| 2| 2| 3| 2| 2| 0| 3| 2|
| 9| 0| 8| 1| 6| 1| 2| 8| 8| 7| 8| 0| 0| 6| 4| 8| 0| 9| 9| 0| 5| 9| 3| 0| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
252 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 2 3 2 2 2 |
Hypothalamus, Compression | 4 4 4 4 |
|__________________________________________________________________________|
Peripheral Nerve | |
|__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Metaplasia, Osseous | 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 1 |
Alveolus, Inflammation, Acute | |
Alveolus, Inflammation, Chronic | |
Active, Focal | 3 3 1 2 3 1 3 2 1 3 3 2 2 2 3 1|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + +|
Cataract | 3|
Cornea, Fibrosis | 2 |
__________________________________________|__________________________________________________________________________|
Page 39
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 1| 2| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 5| 7| 6| 7| 7|
DAY ON TEST | 2| 3| 2| 1| 1| 5| 7| 2| 2| 2| 2| 3| 3| 0| 2| 2| 3| 2| 2| 3| 2| 2| 0| 3| 2|
| 9| 0| 8| 1| 6| 1| 2| 8| 8| 7| 8| 0| 0| 6| 4| 8| 0| 9| 9| 0| 5| 9| 3| 0| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
252 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 2 |
Nephropathy | 2 1 1 1 1 1 1 2 1 |
Renal Tubule, Necrosis | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________|__________________________________________________________________________
Page 40
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 5| 6| 2| 6| 7| 6| 1| 3| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| |
DAY ON TEST | 3| 2| 2| 9| 3| 2| 3| 8| 7| 7| 8| 2| 6| 3| 7| 2| 2| 2| 3| 5| 2| 2| 2| 1| 6| |
| 0| 8| 9| 5| 0| 9| 0| 8| 8| 3| 0| 9| 0| 9| 9| 9| 8| 9| 0| 6| 8| 0| 3| 8| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
252 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Muscularis, Inflammation, Chronic | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 3 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A + + + + + + + + + A A + + + + A + + + + +| 42 |
Infiltration Cellular, Histiocyte | 1 1 2 2 1 1 1 1 1 1| 18 1.2|
Inflammation, Acute, Focal | 2 | 1 2.0|
Inflammation, Chronic | | 1 1.0|
Myxomatous Change | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1| 35 1.1|
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 1.0|
Basophilic Focus | X X X X X X X X X X X X X X X X| 34 |
Clear Cell Focus | X X X | 6 |
Eosinophilic Focus | X | 10 |
Hepatodiaphragmatic Nodule | X X X X X X X | 14 |
Inflammation, Granulomatous | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1| 39 1.1|
Mixed Cell Focus | X X X X | 9 |
Necrosis, Focal | 2 | 1 2.0|
Bile Duct, Hyperplasia | 1 1 2 1 1 1 1 1 | 14 1.1|
|__________________________________________________________________________|____________|
Mesentery | + + + + + | 9 |
Fat, Necrosis | 2 2 1 3 3 | 9 2.1|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 5| 6| 2| 6| 7| 6| 1| 3| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| |
DAY ON TEST | 3| 2| 2| 9| 3| 2| 3| 8| 7| 7| 8| 2| 6| 3| 7| 2| 2| 2| 3| 5| 2| 2| 2| 1| 6| |
| 0| 8| 9| 5| 0| 9| 0| 8| 8| 3| 0| 9| 0| 9| 9| 9| 8| 9| 0| 6| 8| 0| 3| 8| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
252 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 1 | 8 1.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parotid Gland, Atrophy, Diffuse | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Focal | | 1 1.0|
Epithelium, Hyperplasia, Squamous | 3 | 1 3.0|
Epithelium, Inflammation, Focal, | | |
Suppurative | | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Focal | | 1 1.0|
Mineralization | 1 | 1 1.0|
Pigmentation, Hemosiderin | 1 | 1 1.0|
Ulcer | 3 3 3 | 3 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Inflammation, Chronic | | 1 2.0|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Hyperplasia, Focal | | 1 2.0|
Myocardium, Degeneration | 2 1 2 2 2 1 1 2 1 1 1 1 2 1 2 1 1| 34 1.4|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 1 1 2 1 2 2 1 1 | 19 1.3|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 5| 6| 2| 6| 7| 6| 1| 3| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| |
DAY ON TEST | 3| 2| 2| 9| 3| 2| 3| 8| 7| 7| 8| 2| 6| 3| 7| 2| 2| 2| 3| 5| 2| 2| 2| 1| 6| |
| 0| 8| 9| 5| 0| 9| 0| 8| 8| 3| 0| 9| 0| 9| 9| 9| 8| 9| 0| 6| 8| 0| 3| 8| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
252 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Hyperplasia, Focal | 1 | 4 1.0|
Necrosis | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + M + + + + + + M + M + + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 2 3.0|
Cyst | 2 1 1 1 2 1 1 2 1 2 2 1| 22 1.4|
Pars Distalis, Hyperplasia, Focal | 1 2 2 1 2 1 | 13 1.6|
Pars Distalis, Mineralization | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
C-Cell, Hyperplasia | 2 2 2 2 3 2 1 2 1 2 3 3 2 2 2 2| 31 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
Cyst | 2 | 3 2.3|
Hyperplasia, Focal | 2 | 3 1.7|
Inflammation, Chronic | 1 2 2 1 | 8 1.4|
Inflammation, Suppurative | 2 | 2 1.5|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 5 2.6|
Inflammation, Granulomatous | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 5| 6| 2| 6| 7| 6| 1| 3| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| |
DAY ON TEST | 3| 2| 2| 9| 3| 2| 3| 8| 7| 7| 8| 2| 6| 3| 7| 2| 2| 2| 3| 5| 2| 2| 2| 1| 6| |
| 0| 8| 9| 5| 0| 9| 0| 8| 8| 3| 0| 9| 0| 9| 9| 9| 8| 9| 0| 6| 8| 0| 3| 8| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
252 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Inflammation, Suppurative | | 1 1.0|
Cervix, Endometrium, Hyperplasia | 3 | 1 3.0|
Endometrium, Hyperplasia, Cystic | 1 1 1 1 1| 6 1.0|
|__________________________________________________________________________|____________|
Vagina | + + | 2 |
Infiltration Cellular, | | |
Polymorphonuclear | 2 | 1 2.0|
Epithelium, Vacuolization Cytoplasmic| 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + +| 13 |
Deep Cervical, Hemorrhage | | 1 2.0|
Deep Cervical, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Congestion | 3 | 1 3.0|
Mediastinal, Ectasia | 2 | 1 2.0|
Mediastinal, Hemorrhage | 2| 3 1.7|
Mediastinal, Hyperplasia, Lymphoid | 2 2 2| 6 1.7|
Mediastinal, Infiltration Cellular, | | |
Mast Cell | | 1 3.0|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | | 1 2.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
Pancreatic, Pigmentation, Hemosiderin| | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M + M M M M M M M M M M M M M M M M M M M| 2 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ectasia | 1 | 1 1.0|
Hyperplasia, Lymphoid | 2 3 | 2 2.5|
Infiltration Cellular, Histiocyte | 1 2 1 2 2 2 1 1 1 2 1 2 1 1 1 3 1 1 2| 42 1.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 5| 6| 2| 6| 7| 6| 1| 3| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| |
DAY ON TEST | 3| 2| 2| 9| 3| 2| 3| 8| 7| 7| 8| 2| 6| 3| 7| 2| 2| 2| 3| 5| 2| 2| 2| 1| 6| |
| 0| 8| 9| 5| 0| 9| 0| 8| 8| 3| 0| 9| 0| 9| 9| 9| 8| 9| 0| 6| 8| 0| 3| 8| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
252 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 1 1 2 2 1 | 5 1.4|
Hyperplasia, Lymphohistiocytic | 3 3 | 4 3.3|
Lymphoid Follicle, Atrophy | 2 2 2 2 2 2 4 3 2 2 2 3 2 2 2 1 1 | 28 2.2|
Lymphoid Follicle, Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Thymus | + + + M M + + M + + + + + + + + + + + M + + + M M| 41 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 2 1 | 2 1.5|
Duct, Dilatation | 1 3 4 2 1 1 2 1 1 | 23 1.7|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrocephalus | 3 3 3 1 2 | 10 2.3|
Hypothalamus, Compression | 3 3 2 1 | 8 3.1|
|__________________________________________________________________________|____________|
Peripheral Nerve | +| 1 |
|__________________________________________________________________________|____________|
Spinal Cord | +| 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 5| 6| 2| 6| 7| 6| 1| 3| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| |
DAY ON TEST | 3| 2| 2| 9| 3| 2| 3| 8| 7| 7| 8| 2| 6| 3| 7| 2| 2| 2| 3| 5| 2| 2| 2| 1| 6| |
| 0| 8| 9| 5| 0| 9| 0| 8| 8| 3| 0| 9| 0| 9| 9| 9| 8| 9| 0| 6| 8| 0| 3| 8| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
252 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 3 4 | 4 3.5|
Metaplasia, Osseous | | 1 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 | 3 1.0|
Alveolus, Inflammation, Acute | 3 | 1 3.0|
Alveolus, Inflammation, Chronic | | |
Active, Focal | 1 2 1 1 3 1 3 2 1 3 2 1 3 1 3 4 2 2| 34 2.1|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 1 1 | 5 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + | 3 |
Cataract | 3 | 2 3.0|
Cornea, Fibrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | | 1 2.0|
Nephropathy | 1 1 1 1 1 1 1 | 16 1.1|
Renal Tubule, Necrosis | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3| 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 4| 2| 0| 2| 2| 2| 2| 2| 8| 2| 4| 2| 6| 2| 2| 2| 3| 8| 1| 2| 2| 2| 0| 2| 2|
| 7| 8| 5| 7| 8| 8| 7| 8| 9| 8| 0| 8| 1| 6| 4| 1| 0| 5| 9| 4| 8| 8| 0| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Periesophageal Tissue, Hemorrhage | 3 |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Inflammation, Chronic | 2 |
Parasite Metazoan | X X X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X X|
Eosinophilic Focus | X X X X X X |
Hepatodiaphragmatic Nodule | X |
Inflammation, Granulomatous | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1|
Mixed Cell Focus | X X X X|
Necrosis, Focal | |
Bile Duct, Hyperplasia | 2 2 1 2 2 2 2 2 1 2 1 4 2 1 1 2 2 1 1 1 1|
Centrilobular, Degeneration | |
Centrilobular, Necrosis | |
|__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Necrosis | 2 2 2 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 1 3 1 2 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 47
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 4| 2| 0| 2| 2| 2| 2| 2| 8| 2| 4| 2| 6| 2| 2| 2| 3| 8| 1| 2| 2| 2| 0| 2| 2|
| 7| 8| 5| 7| 8| 8| 7| 8| 9| 8| 0| 8| 1| 6| 4| 1| 0| 5| 9| 4| 8| 8| 0| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Parotid Gland, Atrophy, Focal | |
Sublingual Gland, Hypertrophy, Focal | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 |
Ulcer | 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 |
Ulcer | 2 |
Epithelium, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | 3 |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | 3 |
Myocardium, Degeneration | 3 2 2 3 1 2 2 3 3 3 1 1 1 2 1 2 2 2 3 2 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Diffuse | |
Hyperplasia, Focal | 1 1 2 1 1 1 1 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Diffuse | |
Hyperplasia, Focal | 1 1 2 2 2 1 |
Necrosis, Acute | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + M + + + + + + + + + + +|
Cyst, Multiple | 2 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 48
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 4| 2| 0| 2| 2| 2| 2| 2| 8| 2| 4| 2| 6| 2| 2| 2| 3| 8| 1| 2| 2| 2| 0| 2| 2|
| 7| 8| 5| 7| 8| 8| 7| 8| 9| 8| 0| 8| 1| 6| 4| 1| 0| 5| 9| 4| 8| 8| 0| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 1 |
Pars Distalis, Hyperplasia, Focal | 1 1 1 1 1 2 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 2 2 2 2 2 1 2 2 2 3 2 2 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Chronic | 2 2 1 2 1 2 1 2 1 2 1 1 1 1 1 1 1 1|
Inflammation, Suppurative | 2 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Acute | 4 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hyperplasia | 3 3 3 |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | 4 4 |
Interstitial Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 49
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 4| 2| 0| 2| 2| 2| 2| 2| 8| 2| 4| 2| 6| 2| 2| 2| 3| 8| 1| 2| 2| 2| 0| 2| 2|
| 7| 8| 5| 7| 8| 8| 7| 8| 9| 8| 0| 8| 1| 6| 4| 1| 0| 5| 9| 4| 8| 8| 0| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 3 |
Infiltration Cellular, Lymphocyte | |
Infiltration Cellular, Histiocyte | |
|__________________________________________________________________________|
Lymph Node | + + + + + + |
Deep Cervical, Hyperplasia, Lymphoid | |
Mediastinal, Hemorrhage | 2 1 |
Mediastinal, Hyperplasia, Lymphoid | 1 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + M M M M M M M M M + M M M M M M M + + M M M M M|
Infiltration Cellular, Plasma Cell | 3 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphohistiocytic | 2 |
Capsule, Fibrosis, Focal | |
Lymphoid Follicle, Atrophy | 1 2 2 2 1 2 2 2 2 2|
Lymphoid Follicle, Hyperplasia | |
Lymphoid Follicle, Necrosis | |
|__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Duct, Dilatation | 2 2 2 1 1 1 1 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Cyst, Squamous | |
Epidermis, Epidermis, Cyst | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 50
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 4| 2| 0| 2| 2| 2| 2| 2| 8| 2| 4| 2| 6| 2| 2| 2| 3| 8| 1| 2| 2| 2| 0| 2| 2|
| 7| 8| 5| 7| 8| 8| 7| 8| 9| 8| 0| 8| 1| 6| 4| 1| 0| 5| 9| 4| 8| 8| 0| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Femur, Hyperostosis | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 3 3 4 |
Hypothalamus, Compression | 2 3 2 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 |
Alveolar Epithelium, Hyperplasia | 2 1 2 1 |
Alveolus, Inflammation, Acute | 3 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Inflammation, Chronic | 1 1 1 1 |
Ulcer | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Epithelium, Metaplasia, Squamous | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 3 |
Infarct | 3 |
Nephropathy | 3 1 1 1 2 1 2 3 1 3 1 1 2 1 2 1 1 1 2 1|
Artery, Thrombosis | |
__________________________________________|__________________________________________________________________________|
Page 51
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 4| 2| 0| 2| 2| 2| 2| 2| 8| 2| 4| 2| 6| 2| 2| 2| 3| 8| 1| 2| 2| 2| 0| 2| 2|
| 7| 8| 5| 7| 8| 8| 7| 8| 9| 8| 0| 8| 1| 6| 4| 1| 0| 5| 9| 4| 8| 8| 0| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Renal Tubule, Necrosis, Focal | 3 |
Vein, Inflammation, Chronic | 3 |
|__________________________________________________________________________|
Ureter | + |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Mineralization | 3 |
Ulcer | 4 |
__________________________________________|__________________________________________________________________________
Page 52
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 1| 7| 7| 7| 7| 5| 4| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 2| 9| 2| 0| 2| 8| 2| 1| 2| 2| 2| 2| 0| 7| 7| 1| 2| 4| 2| 2| 2| 2| 2| 2| 1| |
| 9| 9| 8| 7| 4| 6| 8| 1| 9| 9| 8| 9| 3| 5| 3| 7| 7| 0| 9| 7| 7| 8| 7| 7| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Periesophageal Tissue, Hemorrhage | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X | 4 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic | | 1 2.0|
Parasite Metazoan | X X | 5 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X | 27 |
Clear Cell Focus | X X X X X X X X X | 18 |
Eosinophilic Focus | X X X | 9 |
Hepatodiaphragmatic Nodule | X X X X | 5 |
Inflammation, Granulomatous | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 30 1.0|
Mixed Cell Focus | X X X X | 8 |
Necrosis, Focal | 2 | 1 2.0|
Bile Duct, Hyperplasia | 2 3 1 2 2 1 2 2 2 2 1 1 1 2 2 1 1 2 1 1 2 1 2| 44 1.6|
Centrilobular, Degeneration | 2 | 1 2.0|
Centrilobular, Necrosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + | 9 |
Fat, Necrosis | 3 1 3 | 7 2.1|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 1| 7| 7| 7| 7| 5| 4| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 2| 9| 2| 0| 2| 8| 2| 1| 2| 2| 2| 2| 0| 7| 7| 1| 2| 4| 2| 2| 2| 2| 2| 2| 1| |
| 9| 9| 8| 7| 4| 6| 8| 1| 9| 9| 8| 9| 3| 5| 3| 7| 7| 0| 9| 7| 7| 8| 7| 7| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 1 1 3 1 | 12 1.5|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parotid Gland, Atrophy, Focal | 2 | 1 2.0|
Sublingual Gland, Hypertrophy, Focal | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 3.0|
Ulcer | | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 | 2 2.5|
Ulcer | | 1 2.0|
Epithelium, Hyperplasia, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Mineralization | | 1 3.0|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrium, Thrombosis | 3 | 2 3.0|
Myocardium, Degeneration | 1 2 1 2 2 1 2 2 1 1 1 2 2 3 1 1 2 2 2 3 | 41 1.9|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Diffuse | 3 | 1 3.0|
Hyperplasia, Focal | 1 1 1 1 1 1 | 14 1.1|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Diffuse | 2 2 | 2 2.0|
Hyperplasia, Focal | 1 2 2 1 | 10 1.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 1| 7| 7| 7| 7| 5| 4| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 2| 9| 2| 0| 2| 8| 2| 1| 2| 2| 2| 2| 0| 7| 7| 1| 2| 4| 2| 2| 2| 2| 2| 2| 1| |
| 9| 9| 8| 7| 4| 6| 8| 1| 9| 9| 8| 9| 3| 5| 3| 7| 7| 0| 9| 7| 7| 8| 7| 7| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Necrosis, Acute | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + M M + + + + + + + + + + + + +| 46 |
Cyst, Multiple | | 1 2.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 1 | 3 1.0|
Pars Distalis, Hyperplasia, Focal | 1 2 1 1 1| 12 1.3|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 1 2 1 3 2 2 2 2 3 2 2 3 2 | 31 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
Inflammation, Chronic | 1 2 1 2 1 1 1 1 1 1 1 1 1 1 1 1 2| 35 1.3|
Inflammation, Suppurative | | 1 2.0|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
Inflammation, Acute | | 1 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 1| 7| 7| 7| 7| 5| 4| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 2| 9| 2| 0| 2| 8| 2| 1| 2| 2| 2| 2| 0| 7| 7| 1| 2| 4| 2| 2| 2| 2| 2| 2| 1| |
| 9| 9| 8| 7| 4| 6| 8| 1| 9| 9| 8| 9| 3| 5| 3| 7| 7| 0| 9| 7| 7| 8| 7| 7| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Inflammation, Chronic Active | 1 1 2 1 1 1 1 2 2 1 1| 18 1.2|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Hyperplasia | 1 | 4 2.5|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Germinal Epithelium, Atrophy | 4 | 3 4.0|
Interstitial Cell, Hyperplasia | 2 2 2| 5 1.6|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 2 2.0|
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + | 11 |
Deep Cervical, Hyperplasia, Lymphoid | 1 | 1 1.0|
Mediastinal, Hemorrhage | | 2 1.5|
Mediastinal, Hyperplasia, Lymphoid | 2 | 2 1.5|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M + M M M M M M M M M M M M M M M M M| 5 |
Infiltration Cellular, Plasma Cell | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Histiocyte | | 1 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 1 | 2 1.5|
Hyperplasia, Lymphohistiocytic | 2 | 2 2.0|
Capsule, Fibrosis, Focal | 1 | 1 1.0|
Lymphoid Follicle, Atrophy | 1 1 2 1 3 1 2 2 2 2 | 20 1.8|
Lymphoid Follicle, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 1| 7| 7| 7| 7| 5| 4| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 2| 9| 2| 0| 2| 8| 2| 1| 2| 2| 2| 2| 0| 7| 7| 1| 2| 4| 2| 2| 2| 2| 2| 2| 1| |
| 9| 9| 8| 7| 4| 6| 8| 1| 9| 9| 8| 9| 3| 5| 3| 7| 7| 0| 9| 7| 7| 8| 7| 7| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Lymphoid Follicle, Necrosis | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M + M + + + + + M + + + + + + M| 45 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 1 1 1 1 1 2 1 1 2 1| 25 1.1|
Duct, Dilatation | 1 2 3 1 1 | 12 1.5|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epidermis, Cyst, Squamous | 2 | 1 2.0|
Epidermis, Epidermis, Cyst | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 1 | 2 1.0|
Femur, Hyperostosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrocephalus | 2 1 1 3 2 | 8 2.4|
Hypothalamus, Compression | 3 3 | 6 2.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 2 | 2 2.5|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 1 | 3 1.0|
Alveolar Epithelium, Hyperplasia | 2 1 | 6 1.5|
Alveolus, Inflammation, Acute | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 1| 7| 7| 7| 7| 5| 4| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 2| 9| 2| 0| 2| 8| 2| 1| 2| 2| 2| 2| 0| 7| 7| 1| 2| 4| 2| 2| 2| 2| 2| 2| 1| |
| 9| 9| 8| 7| 4| 6| 8| 1| 9| 9| 8| 9| 3| 5| 3| 7| 7| 0| 9| 7| 7| 8| 7| 7| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 |
Inflammation, Chronic | 2 2 1 1 2 | 9 1.3|
Ulcer | 2 1 | 2 1.5|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 1.0|
Epithelium, Metaplasia, Squamous | | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydronephrosis | 3 | 2 3.0|
Infarct | 1 | 2 2.0|
Nephropathy | 1 1 1 2 1 1 1 1 1 2 1 1 1 3 1 2 1 1 1 1| 40 1.4|
Artery, Thrombosis | 1 | 1 1.0|
Renal Tubule, Necrosis, Focal | 2 | 2 2.5|
Vein, Inflammation, Chronic | | 1 3.0|
|__________________________________________________________________________|____________|
Ureter | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | 2 | 1 2.0|
Mineralization | | 1 3.0|
Ulcer | 2 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 6| 7| 5| 7| 7| 2| 5| 7| 7| 7| 7| 6| 7| 7| 7| 3| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 5| 7| 4| 1| 3| 2| 1| 2| 7| 2| 2| 2| 2| 6| 2| 2| 2| 1| 2| 2| 2| 2|
| 9| 9| 9| 4| 8| 5| 9| 3| 8| 7| 3| 4| 8| 7| 8| 7| 8| 8| 8| 8| 3| 8| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
14 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Periesophageal Tissue, | |
Inflammation, Chronic | |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + + + A + + + + + + + + + + + + + +|
Myxomatous Change | |
Parasite Metazoan | X X X X X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Cyst | 1 |
Epithelium, Necrosis | 1 |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia | |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X X X X X|
Eosinophilic Focus | X X X X |
Fibrosis, Focal | |
Hepatodiaphragmatic Nodule | X X|
Inflammation, Granulomatous | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Mixed Cell Focus | X X X X X X X X X|
Artery, Hyperplasia, Focal | |
Bile Duct, Hyperplasia | 2 1 1 2 1 2 1 1 2 2 2 2 1 2 1 2 1 2 1 1|
Centrilobular, Degeneration | 3 |
Centrilobular, Necrosis | 3 |
|__________________________________________________________________________|
Mesentery | + + + +|
Fat, Necrosis | 3 2 2|
__________________________________________|__________________________________________________________________________|
Page 59
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 6| 7| 5| 7| 7| 2| 5| 7| 7| 7| 7| 6| 7| 7| 7| 3| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 5| 7| 4| 1| 3| 2| 1| 2| 7| 2| 2| 2| 2| 6| 2| 2| 2| 1| 2| 2| 2| 2|
| 9| 9| 9| 4| 8| 5| 9| 3| 8| 7| 3| 4| 8| 7| 8| 7| 8| 8| 8| 8| 3| 8| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
14 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 |
Acinus, Atrophy | 1 1 1 1 1 2 |
Acinus, Hyperplasia, Focal | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Inflammation, Acute | 1 |
Ulcer | 3 3 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 2 3 |
|__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | 3 3 |
Myocardium, Degeneration | 2 1 1 2 3 1 1 3 2 3 3 2 2 2 2 3 2 2|
Myocardium, Necrosis, Focal | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 1 1 1 2 1 2 |
Necrosis, Focal | 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 1 3 1 1 3 1 2 2 1 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________|__________________________________________________________________________|
Page 60
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 6| 7| 5| 7| 7| 2| 5| 7| 7| 7| 7| 6| 7| 7| 7| 3| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 5| 7| 4| 1| 3| 2| 1| 2| 7| 2| 2| 2| 2| 6| 2| 2| 2| 1| 2| 2| 2| 2|
| 9| 9| 9| 4| 8| 5| 9| 3| 8| 7| 3| 4| 8| 7| 8| 7| 8| 8| 8| 8| 3| 8| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
14 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Parathyroid Gland | + M + M + + + M + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | 2 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 1 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 1 1 1 2 3 1 1 1 1 4 2 1 3 2 4 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
Inflammation, Chronic | 1 2 2 2 1 2 2 1 2 2 2 1 2 2 2 2 2 2 2 2 2 2|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 2 1 1 1 1 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Fibrosis | 1 |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + |
__________________________________________|__________________________________________________________________________|
Page 61
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 6| 7| 5| 7| 7| 2| 5| 7| 7| 7| 7| 6| 7| 7| 7| 3| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 5| 7| 4| 1| 3| 2| 1| 2| 7| 2| 2| 2| 2| 6| 2| 2| 2| 1| 2| 2| 2| 2|
| 9| 9| 9| 4| 8| 5| 9| 3| 8| 7| 3| 4| 8| 7| 8| 7| 8| 8| 8| 8| 3| 8| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
14 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Mediastinal, Ectasia | |
Mediastinal, Hyperplasia, Lymphoid | 1 1 |
Pancreatic, Ectasia | 3 |
Pancreatic, Hemorrhage | |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M + M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 3 |
Fibrosis | 3 |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | 2 |
Necrosis, Lymphoid | 3 |
Endothelial Cell, Hyperplasia | 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 3 |
Hematopoietic Cell Proliferation | 1 |
Hyperplasia, Lymphohistiocytic | 2 |
Necrosis, Focal | 3 |
Lymphoid Follicle, Atrophy | 3 2 2 2 2 3 3 2 2 2 1 2 2 2 2|
Lymphoid Follicle, Hyperplasia | 2 |
|__________________________________________________________________________|
Thymus | + + + M + + + + + + + + M M + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 |
Duct, Dilatation, Diffuse | |
Duct, Dilatation | 1 2 1 3 1 1 1 1 1 1 1 1 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Osseous | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 62
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 6| 7| 5| 7| 7| 2| 5| 7| 7| 7| 7| 6| 7| 7| 7| 3| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 5| 7| 4| 1| 3| 2| 1| 2| 7| 2| 2| 2| 2| 6| 2| 2| 2| 1| 2| 2| 2| 2|
| 9| 9| 9| 4| 8| 5| 9| 3| 8| 7| 3| 4| 8| 7| 8| 7| 8| 8| 8| 8| 3| 8| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
14 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 2 2 3 2 |
Hippocampus, Cerebrum, Degeneration | |
Hypothalamus, Compression | 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Emphysema, Focal | |
Hemorrhage | 3 |
Metaplasia, Osseous | 1 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 1 |
Alveolus, Emphysema, Focal | 2 |
Alveolus, Inflammation, Acute | |
Alveolus, Inflammation, Chronic | |
Active, Focal | 1 1 1|
Mediastinum, Inflammation, Chronic | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 |
Ulcer | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | |
Cataract | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 63
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 6| 7| 5| 7| 7| 2| 5| 7| 7| 7| 7| 6| 7| 7| 7| 3| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 5| 7| 4| 1| 3| 2| 1| 2| 7| 2| 2| 2| 2| 6| 2| 2| 2| 1| 2| 2| 2| 2|
| 9| 9| 9| 4| 8| 5| 9| 3| 8| 7| 3| 4| 8| 7| 8| 7| 8| 8| 8| 8| 3| 8| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
14 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Glomerulosclerosis | 2 |
Nephropathy | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Renal Tubule, Necrosis, Focal | 1 |
Renal Tubule, Pigmentation, | |
Lipofuscin | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
__________________________________________|__________________________________________________________________________
Page 64
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 1| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| |
DAY ON TEST | 2| 2| 2| 3| 0| 2| 2| 2| 5| 2| 1| 2| 2| 2| 4| 2| 2| 0| 2| 1| 2| 2| 7| 1| 7| |
| 8| 7| 8| 1| 5| 8| 7| 7| 1| 7| 3| 8| 8| 8| 5| 7| 4| 3| 9| 3| 9| 8| 7| 5| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
14 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Muscularis, Periesophageal Tissue, | | |
Inflammation, Chronic | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Myxomatous Change | 2 | 1 2.0|
Parasite Metazoan | X X X | 8 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Cyst | | 1 1.0|
Epithelium, Necrosis | | 1 1.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Peyer's Patch, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X | 27 |
Clear Cell Focus | X X X X X X X X X X| 22 |
Eosinophilic Focus | X X X X X X X X | 12 |
Fibrosis, Focal | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | X X X | 5 |
Inflammation, Granulomatous | 1 2 1 1 1 1 1 1 1 1 1| 26 1.0|
Mixed Cell Focus | X X X X X X X X | 17 |
Artery, Hyperplasia, Focal | 2 | 1 2.0|
Bile Duct, Hyperplasia | 2 1 1 2 1 1 1 1 2 1 2 2 2 2 1 2 2 2 1 3 1| 41 1.5|
Centrilobular, Degeneration | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 1| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| |
DAY ON TEST | 2| 2| 2| 3| 0| 2| 2| 2| 5| 2| 1| 2| 2| 2| 4| 2| 2| 0| 2| 1| 2| 2| 7| 1| 7| |
| 8| 7| 8| 1| 5| 8| 7| 7| 1| 7| 3| 8| 8| 8| 5| 7| 4| 3| 9| 3| 9| 8| 7| 5| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
14 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Centrilobular, Necrosis | | 1 3.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + | 11 |
Fat, Necrosis | 3 3 2 4 3 2 2 | 10 2.6|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 1.0|
Acinus, Atrophy | 1 1 2 1 1 2 3 1| 14 1.4|
Acinus, Hyperplasia, Focal | 1 2 | 2 1.5|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 | 1 3.0|
Inflammation, Acute | | 1 1.0|
Ulcer | | 2 3.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 3 2.7|
|__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrium, Thrombosis | 3 3 | 4 3.0|
Myocardium, Degeneration | 3 3 2 3 2 2 2 2 3 2 2 3 3 2 3 3 2 2 1 2 2 2 2| 41 2.2|
Myocardium, Necrosis, Focal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 1| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| |
DAY ON TEST | 2| 2| 2| 3| 0| 2| 2| 2| 5| 2| 1| 2| 2| 2| 4| 2| 2| 0| 2| 1| 2| 2| 7| 1| 7| |
| 8| 7| 8| 1| 5| 8| 7| 7| 1| 7| 3| 8| 8| 8| 5| 7| 4| 3| 9| 3| 9| 8| 7| 5| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
14 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Hyperplasia, Focal | 1 2 1 1 1 1 1 1 1| 16 1.2|
Necrosis, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 2 2 1 2 2 2 3 | 17 1.8|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + M + M + + + + + + M + + + + + + + + + + + + +| 44 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Cyst | 1 | 3 1.7|
Pars Distalis, Hyperplasia, Focal | 1 1 1 1 2 2 1 1 | 12 1.4|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 2 1 1 1 2 1 2 3 2 3 1 4 4 3 2 1 3 2| 36 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 2 1.5|
Inflammation, Chronic | 2 2 2 2 2 2 2 1 1 2 1 2 2 1 2 2 1 2 2 1 2 2| 44 1.8|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 2 2 2 1 1 1 1 1 1| 16 1.4|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 1| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| |
DAY ON TEST | 2| 2| 2| 3| 0| 2| 2| 2| 5| 2| 1| 2| 2| 2| 4| 2| 2| 0| 2| 1| 2| 2| 7| 1| 7| |
| 8| 7| 8| 1| 5| 8| 7| 7| 1| 7| 3| 8| 8| 8| 5| 7| 4| 3| 9| 3| 9| 8| 7| 5| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
14 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Atrophy | 2 | 1 2.0|
Fibrosis | | 1 1.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Germinal Epithelium, Atrophy | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 17 |
Mediastinal, Ectasia | 1 1 | 2 1.0|
Mediastinal, Hyperplasia, Lymphoid | 1 2 1 1 1 | 7 1.1|
Pancreatic, Ectasia | | 1 3.0|
Pancreatic, Hemorrhage | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M + M M M M M M M + M M M + + M M M M| 5 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | | 2 2.5|
Fibrosis | | 1 3.0|
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
Necrosis, Lymphoid | | 1 3.0|
Endothelial Cell, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Focal | 2 | 2 2.5|
Hematopoietic Cell Proliferation | 1 | 2 1.0|
Hyperplasia, Lymphohistiocytic | 2 | 2 2.0|
Necrosis, Focal | | 1 3.0|
Lymphoid Follicle, Atrophy | 3 2 2 2 2 3 2 1 2 2 | 25 2.1|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 1| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| |
DAY ON TEST | 2| 2| 2| 3| 0| 2| 2| 2| 5| 2| 1| 2| 2| 2| 4| 2| 2| 0| 2| 1| 2| 2| 7| 1| 7| |
| 8| 7| 8| 1| 5| 8| 7| 7| 1| 7| 3| 8| 8| 8| 5| 7| 4| 3| 9| 3| 9| 8| 7| 5| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
14 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Lymphoid Follicle, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + M M + + + + + + + + +| 44 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3 1 1 1 2| 37 1.1|
Duct, Dilatation, Diffuse | 1 | 1 1.0|
Duct, Dilatation | 1 2 1 1 1 1 2 1 2 1 1 1 | 24 1.3|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Metaplasia, Osseous | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrocephalus | 1 2 2 | 7 2.0|
Hippocampus, Cerebrum, Degeneration | 3 | 1 3.0|
Hypothalamus, Compression | 2 | 2 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Emphysema, Focal | 1 | 1 1.0|
Hemorrhage | | 1 3.0|
Metaplasia, Osseous | 1 1 | 3 1.0|
Thrombosis | 4 | 1 4.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 1 | 4 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 1| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| |
DAY ON TEST | 2| 2| 2| 3| 0| 2| 2| 2| 5| 2| 1| 2| 2| 2| 4| 2| 2| 0| 2| 1| 2| 2| 7| 1| 7| |
| 8| 7| 8| 1| 5| 8| 7| 7| 1| 7| 3| 8| 8| 8| 5| 7| 4| 3| 9| 3| 9| 8| 7| 5| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
14 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Alveolus, Emphysema, Focal | | 1 2.0|
Alveolus, Inflammation, Acute | 4 | 1 4.0|
Alveolus, Inflammation, Chronic | | |
Active, Focal | 1 1 1 | 6 1.0|
Mediastinum, Inflammation, Chronic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 1 1 1 2 | 7 1.1|
Ulcer | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + | 1 |
Cataract | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Glomerulosclerosis | | 1 2.0|
Nephropathy | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3 1| 42 1.1|
Renal Tubule, Necrosis, Focal | | 1 1.0|
Renal Tubule, Pigmentation, | | |
Lipofuscin | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 6| 7| 7| 6| 7| 7| 6| 6| 4| 7| 7| 7| 4| 5| 4| 7| 7| 6| 5| 6|
DAY ON TEST | 2| 8| 2| 3| 2| 8| 2| 2| 9| 2| 2| 7| 8| 8| 2| 1| 2| 9| 8| 6| 2| 2| 7| 6| 3|
| 7| 2| 8| 0| 8| 6| 7| 7| 5| 7| 7| 4| 6| 4| 7| 6| 8| 2| 6| 2| 8| 9| 4| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
42 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 3 |
Inflammation, Chronic | 3 |
Myxomatous Change | 2 1 |
Parasite Metazoan | X X X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 1 |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X |
Clear Cell Focus | X X X X X X X X X|
Eosinophilic Focus | X X |
Fatty Change, Focal | 1 |
Fibrosis, Focal | 2 |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Granulomatous | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Mixed Cell Focus | X X X X |
Bile Duct, Hyperplasia | 2 1 2 1 2 2 2 2 1 2 3 1 1 1 1 1 2|
Centrilobular, Degeneration | 2|
Centrilobular, Fatty Change | |
Centrilobular, Necrosis | 3 |
|__________________________________________________________________________|
Mesentery | + + + + +|
Fat, Necrosis | 2 3 3 2 3|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 71
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 6| 7| 7| 6| 7| 7| 6| 6| 4| 7| 7| 7| 4| 5| 4| 7| 7| 6| 5| 6|
DAY ON TEST | 2| 8| 2| 3| 2| 8| 2| 2| 9| 2| 2| 7| 8| 8| 2| 1| 2| 9| 8| 6| 2| 2| 7| 6| 3|
| 7| 2| 8| 0| 8| 6| 7| 7| 5| 7| 7| 4| 6| 4| 7| 6| 8| 2| 6| 2| 8| 9| 4| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
42 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 2 2 1 1 |
Acinus, Hyperplasia, Focal | |
Duct, Necrosis | 3 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + M + + + + + + + + + + + + + + + +|
Duct, Parotid Gland, Sublingual | |
Gland, Mineralization | 2 |
Parotid Gland, Atrophy, Focal | 3 |
Sublingual Gland, Atrophy, Focal | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Squamous | 2 2 |
Inflammation, Chronic | 2 |
Ulcer | 4 3 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
Ulcer | 2 1 2 |
Epithelium, Hyperplasia, Focal | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Inflammation, Chronic | |
Myocardium, Degeneration | 2 1 1 3 2 2 3 2 3 2 3 2 2 2 2 3 1 3 1 2 3|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 1 2 2 2 1 4 |
Necrosis, Acute | 4 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hyperplasia, Focal | 3 3 1 3 1 1 1 3 |
__________________________________________|__________________________________________________________________________|
Page 72
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 6| 7| 7| 6| 7| 7| 6| 6| 4| 7| 7| 7| 4| 5| 4| 7| 7| 6| 5| 6|
DAY ON TEST | 2| 8| 2| 3| 2| 8| 2| 2| 9| 2| 2| 7| 8| 8| 2| 1| 2| 9| 8| 6| 2| 2| 7| 6| 3|
| 7| 2| 8| 0| 8| 6| 7| 7| 5| 7| 7| 4| 6| 4| 7| 6| 8| 2| 6| 2| 8| 9| 4| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
42 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Necrosis, Focal | 1 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + M +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 2 1 |
Pars Distalis, Hyperplasia, Focal | 1 2 2 1 1 1 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 3 3 2 2 2 3 1 1 2 2 2 2 2 1 2 2 2 1 1 2 1|
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | + |
Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Inflammation, Chronic | 2 2 2 1 1 1 1 2 1 1 1 1 1 2 2 1 2 1 1 1 2 2 1|
Inflammation, Suppurative | |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 |
Inflammation, Chronic Active | 3 2 1 2 1 2 1 1 1 1 2 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hyperplasia | 2 2 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 73
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 6| 7| 7| 6| 7| 7| 6| 6| 4| 7| 7| 7| 4| 5| 4| 7| 7| 6| 5| 6|
DAY ON TEST | 2| 8| 2| 3| 2| 8| 2| 2| 9| 2| 2| 7| 8| 8| 2| 1| 2| 9| 8| 6| 2| 2| 7| 6| 3|
| 7| 2| 8| 0| 8| 6| 7| 7| 5| 7| 7| 4| 6| 4| 7| 6| 8| 2| 6| 2| 8| 9| 4| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
42 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 4 |
Artery, Necrosis | |
Germinal Epithelium, Atrophy | 2 |
Interstitial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + |
Mediastinal, Ectasia | |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 2 |
Renal, Ectasia | |
Renal, Infiltration Cellular, Plasma | |
Cell | |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M + M + M + + M M M M M M M M M M + M M M|
Ectasia | 3 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 2 1 1 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 2|
Hyperplasia, Lymphohistiocytic | 2 |
Lymphoid Follicle, Atrophy | 2 3 2 3 2 2 1 2 2 3 2 3 4 |
Lymphoid Follicle, Hyperplasia | 2|
|__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + + + + + + + M M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 74
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 6| 7| 7| 6| 7| 7| 6| 6| 4| 7| 7| 7| 4| 5| 4| 7| 7| 6| 5| 6|
DAY ON TEST | 2| 8| 2| 3| 2| 8| 2| 2| 9| 2| 2| 7| 8| 8| 2| 1| 2| 9| 8| 6| 2| 2| 7| 6| 3|
| 7| 2| 8| 0| 8| 6| 7| 7| 5| 7| 7| 4| 6| 4| 7| 6| 8| 2| 6| 2| 8| 9| 4| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
42 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Duct, Dilatation | 1 1 1 1 1 1 1 2 1 2 1 1 2 2 1 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 1 3 2 3 4 1 1 |
Cerebrum, Degeneration, Focal | 2 |
Hypothalamus, Compression | 3 4 4 3 |
Medulla, Degeneration, Focal | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 1 |
Alveolus, Inflammation, Chronic | |
Active, Focal | 1 1 1 1 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 1 1 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 75
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 6| 7| 7| 6| 7| 7| 6| 6| 4| 7| 7| 7| 4| 5| 4| 7| 7| 6| 5| 6|
DAY ON TEST | 2| 8| 2| 3| 2| 8| 2| 2| 9| 2| 2| 7| 8| 8| 2| 1| 2| 9| 8| 6| 2| 2| 7| 6| 3|
| 7| 2| 8| 0| 8| 6| 7| 7| 5| 7| 7| 4| 6| 4| 7| 6| 8| 2| 6| 2| 8| 9| 4| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
42 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infarct | 1 |
Nephropathy | 1 2 1 3 2 1 2 2 1 1 1 1 1 1 1 1 1 1 3 2|
Pelvis, Inflammation, Suppurative | 3 |
Renal Tubule, Necrosis, Focal | 1 |
Renal Tubule, Pigmentation, | |
Lipofuscin | 3 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 76
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 5| 5| 7| 4| 7| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 5| 6| 7| |
DAY ON TEST | 2| 7| 2| 2| 1| 2| 7| 2| 8| 2| 2| 2| 2| 2| 8| 2| 1| 3| 2| 2| 8| 2| 2| 3| 2| |
| 7| 4| 6| 7| 9| 8| 9| 9| 2| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 8| 5| 8| 1| 0| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
42 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Erosion | 2 | 2 2.5|
Inflammation, Chronic | | 1 3.0|
Myxomatous Change | 1 | 3 1.3|
Parasite Metazoan | X | 4 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Focal | | 1 1.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | | 1 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X| 22 |
Clear Cell Focus | X X X X X X X X X X X X X X | 23 |
Eosinophilic Focus | X X X| 5 |
Fatty Change, Focal | | 1 1.0|
Fibrosis, Focal | | 1 2.0|
Hepatodiaphragmatic Nodule | X X X X X | 7 |
Inflammation, Granulomatous | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 32 1.0|
Mixed Cell Focus | X X X X X X X X X| 13 |
Bile Duct, Hyperplasia | 1 1 2 1 1 1 1 1 1 1 1 1 2 2 1| 32 1.4|
Centrilobular, Degeneration | | 1 2.0|
Centrilobular, Fatty Change | 3 | 1 3.0|
Centrilobular, Necrosis | 3 | 2 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 5| 5| 7| 4| 7| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 5| 6| 7| |
DAY ON TEST | 2| 7| 2| 2| 1| 2| 7| 2| 8| 2| 2| 2| 2| 2| 8| 2| 1| 3| 2| 2| 8| 2| 2| 3| 2| |
| 7| 4| 6| 7| 9| 8| 9| 9| 2| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 8| 5| 8| 1| 0| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
42 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Mesentery | + + + + | 9 |
Fat, Necrosis | 4 3 2 2 | 9 2.7|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 2 2 1 1 1 1 1 2| 14 1.4|
Acinus, Hyperplasia, Focal | 2 | 1 2.0|
Duct, Necrosis | | 1 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Duct, Parotid Gland, Sublingual | | |
Gland, Mineralization | | 1 2.0|
Parotid Gland, Atrophy, Focal | | 1 3.0|
Sublingual Gland, Atrophy, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal, Squamous | | 2 2.0|
Inflammation, Chronic | | 1 2.0|
Ulcer | 4 3 | 4 3.5|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 1.0|
Ulcer | 3 2 | 5 2.0|
Epithelium, Hyperplasia, Focal | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrium, Inflammation, Chronic | 2 | 1 2.0|
Myocardium, Degeneration | 3 1 1 2 3 2 3 1 1 2 3 2 3 1 1 1 2 2 1 2 3 | 42 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 5| 5| 7| 4| 7| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 5| 6| 7| |
DAY ON TEST | 2| 7| 2| 2| 1| 2| 7| 2| 8| 2| 2| 2| 2| 2| 8| 2| 1| 3| 2| 2| 8| 2| 2| 3| 2| |
| 7| 4| 6| 7| 9| 8| 9| 9| 2| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 8| 5| 8| 1| 0| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
42 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 1 1 1 1 1 1 1 1 4 1| 17 1.5|
Necrosis, Acute | | 1 4.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 4 3 | 3 3.0|
Hyperplasia, Focal | 1 2 2 2 | 12 1.9|
Necrosis, Focal | | 1 1.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + + + M + + + + + + + + + M + +| 45 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 1 2 | 5 1.4|
Pars Distalis, Hyperplasia, Focal | 1 1 1 1 1 2 1 1 2 1 1 | 17 1.2|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 2 1 2 2 4 2 4 1 2 1 2 2 2 1 1 2| 40 1.9|
Follicle, Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | | 1 |
Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 5| 5| 7| 4| 7| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 5| 6| 7| |
DAY ON TEST | 2| 7| 2| 2| 1| 2| 7| 2| 8| 2| 2| 2| 2| 2| 8| 2| 1| 3| 2| 2| 8| 2| 2| 3| 2| |
| 7| 4| 6| 7| 9| 8| 9| 9| 2| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 8| 5| 8| 1| 0| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
42 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Cyst | 2 3 | 3 2.3|
Inflammation, Chronic | 2 2 2 1 2 1 1 1 2 1 2 2 1 2 2 2 1 1 2| 42 1.5|
Inflammation, Suppurative | 2 3 | 2 2.5|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | | 1 1.0|
Inflammation, Chronic Active | 1 2 1 2 3 1 2 1| 19 1.6|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 | 1 3.0|
Hyperplasia | | 2 2.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 2 4.0|
Artery, Necrosis | 3 | 1 3.0|
Germinal Epithelium, Atrophy | | 1 2.0|
Interstitial Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 10 |
Mediastinal, Ectasia | 2 2 | 2 2.0|
Mediastinal, Hyperplasia, Lymphoid | 2 2 | 2 2.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
Renal, Ectasia | 3 | 1 3.0|
Renal, Infiltration Cellular, Plasma | | |
Cell | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M + + M M M M M M M M M + M M M +| 9 |
Ectasia | | 1 3.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 5| 5| 7| 4| 7| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 5| 6| 7| |
DAY ON TEST | 2| 7| 2| 2| 1| 2| 7| 2| 8| 2| 2| 2| 2| 2| 8| 2| 1| 3| 2| 2| 8| 2| 2| 3| 2| |
| 7| 4| 6| 7| 9| 8| 9| 9| 2| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 8| 5| 8| 1| 0| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
42 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 2 | 2 2.0|
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 | 18 1.2|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 1 | 3 1.3|
Hyperplasia, Lymphohistiocytic | 2 | 2 2.0|
Lymphoid Follicle, Atrophy | 1 2 4 3 2 2 2 2 2 2 2 2 2 2 2 2| 29 2.2|
Lymphoid Follicle, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + M M + + + + M + + + + + + +| 43 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 31 1.0|
Duct, Dilatation | 1 1 2 1 2 2 1 2 1 1 1 2| 27 1.3|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrocephalus | 3 2 | 9 2.2|
Cerebrum, Degeneration, Focal | | 1 2.0|
Hypothalamus, Compression | 3 | 5 3.4|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 5| 5| 7| 4| 7| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 5| 6| 7| |
DAY ON TEST | 2| 7| 2| 2| 1| 2| 7| 2| 8| 2| 2| 2| 2| 2| 8| 2| 1| 3| 2| 2| 8| 2| 2| 3| 2| |
| 7| 4| 6| 7| 9| 8| 9| 9| 2| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 8| 5| 8| 1| 0| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
42 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
Medulla, Degeneration, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 | 3 1.0|
Alveolus, Inflammation, Chronic | | |
Active, Focal | 2 1 2 1 1 3 | 11 1.4|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 1| 8 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 | 1 1.0|
Infarct | 1 | 2 1.0|
Nephropathy | 1 1 3 1 3 2 1 1 1 2 2 3 1 1 1 1 2 1 1 1 1| 41 1.5|
Pelvis, Inflammation, Suppurative | | 1 3.0|
Renal Tubule, Necrosis, Focal | 1 | 2 1.0|
Renal Tubule, Pigmentation, | | |
Lipofuscin | 2 | 3 2.3|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 6| 6| 3| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 6| 6| 1| 7| 7| 7| 1|
DAY ON TEST | 2| 2| 5| 2| 2| 2| 9| 2| 0| 2| 2| 4| 2| 3| 2| 2| 2| 2| 6| 8| 2| 0| 2| 0| 6|
| 9| 2| 2| 7| 8| 8| 1| 7| 7| 9| 7| 0| 7| 3| 8| 8| 8| 7| 9| 9| 0| 9| 8| 8| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
126 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Periesophageal Tissue, Hemorrhage | |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
|__________________________________________________________________________|
Intestine Large, Rectum | A + A + + + A + + + + + + + + + + + A + + + + + +|
Erosion | 2 2 |
Infiltration Cellular, Histiocyte | 1 1 1 |
Inflammation, Chronic | 2 2 |
Myxomatous Change | 1 1 1 1 1 1 1 1 1 1 1 |
Parasite Metazoan | X |
Ulcer | 1 |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X X X X X X X X |
Clear Cell Focus | X X X X X X X X |
Eosinophilic Focus | X X |
Fibrosis, Focal | 2 |
Hepatodiaphragmatic Nodule | X X X X X X |
Inflammation, Granulomatous | 1 1 2 1 1 2 1 1 1 1 1 1 1 |
Mixed Cell Focus | X X X X X X |
Bile Duct, Hyperplasia | 2 1 2 3 4 2 2 1 1 1 1 1 1 1 1 1 1 2 1 2 1 |
Centrilobular, Degeneration | |
Centrilobular, Fatty Change | 3 |
Centrilobular, Necrosis | 3 1 |
|__________________________________________________________________________|
Mesentery | + + + + |
__________________________________________|__________________________________________________________________________|
Page 83
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 6| 6| 3| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 6| 6| 1| 7| 7| 7| 1|
DAY ON TEST | 2| 2| 5| 2| 2| 2| 9| 2| 0| 2| 2| 4| 2| 3| 2| 2| 2| 2| 6| 8| 2| 0| 2| 0| 6|
| 9| 2| 2| 7| 8| 8| 1| 7| 7| 9| 7| 0| 7| 3| 8| 8| 8| 7| 9| 9| 0| 9| 8| 8| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
126 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Accessory Spleen | |
Hemorrhage | |
Fat, Inflammation, Granulomatous | |
Fat, Necrosis | 3 2 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 3 1 1 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Squamous | |
Ulcer | 3 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Ulcer | 1 3 |
Epithelium, Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | |
Myocardium, Degeneration | 2 2 2 2 1 3 4 2 2 2 2 3 1 2 2 2 1 3 2 1 |
Vein, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 1 3 2 1 2 2 2 1 3 |
Hyperplasia | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 1 2 2 2 1 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 84
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 6| 6| 3| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 6| 6| 1| 7| 7| 7| 1|
DAY ON TEST | 2| 2| 5| 2| 2| 2| 9| 2| 0| 2| 2| 4| 2| 3| 2| 2| 2| 2| 6| 8| 2| 0| 2| 0| 6|
| 9| 2| 2| 7| 8| 8| 1| 7| 7| 9| 7| 0| 7| 3| 8| 8| 8| 7| 9| 9| 0| 9| 8| 8| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
126 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Hyperplasia | 1 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Cyst | |
Hyperplasia | |
Necrosis, Focal | 3 |
Pars Distalis, Hyperplasia, Focal | 1 1 1 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 3 1 3 2 1 1 2 2 2 2 2 2 2 2 4 |
Follicle, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | |
Inflammation, Chronic | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Granuloma Sperm | 1 |
Inflammation, Acute | |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 3 |
Inflammation, Chronic | 1 1 2 2 2 2 1 1 1 1 2 1 2 2 1 2 2 1|
Inflammation, Suppurative | |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + M + + + + +|
Inflammation, Chronic Active | 2 1 1 3 1 1 1 1 1 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + M + + + + +|
Hyperplasia | 2 2 |
__________________________________________|__________________________________________________________________________|
Page 85
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 6| 6| 3| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 6| 6| 1| 7| 7| 7| 1|
DAY ON TEST | 2| 2| 5| 2| 2| 2| 9| 2| 0| 2| 2| 4| 2| 3| 2| 2| 2| 2| 6| 8| 2| 0| 2| 0| 6|
| 9| 2| 2| 7| 8| 8| 1| 7| 7| 9| 7| 0| 7| 3| 8| 8| 8| 7| 9| 9| 0| 9| 8| 8| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
126 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | 4 |
Interstitial Cell, Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
|__________________________________________________________________________|
Lymph Node | + + + + + + + |
Deep Cervical, Angiectasis | 3 |
Mediastinal, Angiectasis | 2 |
Mediastinal, Ectasia | |
Mediastinal, Hemorrhage | |
Mediastinal, Hyperplasia, Lymphoid | 1 |
Mediastinal, Hyperplasia, Plasma Cell| |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M + M M M M M M + M M M|
Ectasia | 3 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + A + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 3 |
Infiltration Cellular, Histiocyte | 1 2 2 1 2 2 2 1 2 1 2 1 2 2 2 1 1 2 |
Inflammation, Granulomatous | 1 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | 2 1 1 |
Hyperplasia, Lymphohistiocytic | 4 3 3 3 1 3 |
Capsule, Fibrosis, Focal | 1 |
Lymphoid Follicle, Atrophy | 3 2 2 2 2 2 3 3 2 2 4 3 2|
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + M + M M M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 86
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 6| 6| 3| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 6| 6| 1| 7| 7| 7| 1|
DAY ON TEST | 2| 2| 5| 2| 2| 2| 9| 2| 0| 2| 2| 4| 2| 3| 2| 2| 2| 2| 6| 8| 2| 0| 2| 0| 6|
| 9| 2| 2| 7| 8| 8| 1| 7| 7| 9| 7| 0| 7| 3| 8| 8| 8| 7| 9| 9| 0| 9| 8| 8| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
126 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
Mammary Gland | + + M + + + + + + + + M + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 2 1 2 1 1 |
Duct, Dilatation | 2 2 1 1 1 3 1 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sebaceous Gland, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
Hemorrhage | 4 |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 3 3 3 4 |
Hypothalamus, Compression | 3 4 3 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | |
Hemorrhage | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 3 4|
Infiltration Cellular, Histiocyte | 3 |
Myxomatous Change | 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 4 1 |
Alveolar Epithelium, Hyperplasia | |
Alveolar Epithelium, Metaplasia, | |
Squamous | 1 |
Alveolus, Emphysema, Focal | |
Alveolus, Inflammation, Acute | 4 2 |
Alveolus, Inflammation, Chronic | |
__________________________________________|__________________________________________________________________________|
Page 87
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
_____________________________________________________________________________________________________________________
| 6| 6| 3| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 6| 6| 1| 7| 7| 7| 1|
DAY ON TEST | 2| 2| 5| 2| 2| 2| 9| 2| 0| 2| 2| 4| 2| 3| 2| 2| 2| 2| 6| 8| 2| 0| 2| 0| 6|
| 9| 2| 2| 7| 8| 8| 1| 7| 7| 9| 7| 0| 7| 3| 8| 8| 8| 7| 9| 9| 0| 9| 8| 8| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
126 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Active, Focal | 2 3 2 2 1 1 |
Artery, Thrombosis | 4 |
Interstitium, Fibrosis, Focal | 1 |
Interstitium, Alveolus, Inflammation | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 2 2 1 1 |
Thrombosis | 3 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic | 2 1 2 1 |
Ulcer | 2 |
Epithelium, Metaplasia, Squamous | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | |
Cataract | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 2 2 1 2 1 1 1 2 3 2 1 1 2 3 |
|__________________________________________________________________________|
Urethra | |
Inflammation, Suppurative | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________|__________________________________________________________________________
Page 88
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 7| 7| 7| 6| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 6| 7| 7| |
DAY ON TEST | 2| 2| 6| 2| 8| 2| 2| 2| 7| 6| 3| 2| 2| 2| 2| 2| 2| 2| 2| 5| 2| 6| 0| 2| 2| |
| 0| 8| 1| 9| 4| 7| 8| 8| 9| 1| 7| 7| 8| 9| 9| 7| 7| 7| 8| 6| 7| 0| 4| 7| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
126 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Periesophageal Tissue, Hemorrhage | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 3 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + A + + +| 45 |
Erosion | | 2 2.0|
Infiltration Cellular, Histiocyte | 1 | 4 1.0|
Inflammation, Chronic | 2 2 1 | 5 1.8|
Myxomatous Change | 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 25 1.0|
Parasite Metazoan | X X | 3 |
Ulcer | | 1 1.0|
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 1.0|
Basophilic Focus | X X X X X X X X X X | 19 |
Clear Cell Focus | X X X X X X X X | 16 |
Eosinophilic Focus | X X| 4 |
Fibrosis, Focal | | 1 2.0|
Hepatodiaphragmatic Nodule | X X X | 9 |
Inflammation, Granulomatous | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 27 1.1|
Mixed Cell Focus | X X X X X | 11 |
Bile Duct, Hyperplasia | 1 2 1 2 2 2 4 2 1 1 1 1 2 1 2 1 1 2| 39 1.6|
Centrilobular, Degeneration | 1 | 1 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 7| 7| 7| 6| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 6| 7| 7| |
DAY ON TEST | 2| 2| 6| 2| 8| 2| 2| 2| 7| 6| 3| 2| 2| 2| 2| 2| 2| 2| 2| 5| 2| 6| 0| 2| 2| |
| 0| 8| 1| 9| 4| 7| 8| 8| 9| 1| 7| 7| 8| 9| 9| 7| 7| 7| 8| 6| 7| 0| 4| 7| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
126 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Centrilobular, Fatty Change | | 1 3.0|
Centrilobular, Necrosis | 2 | 3 2.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + | 13 |
Accessory Spleen | X | 1 |
Hemorrhage | 2 | 1 2.0|
Fat, Inflammation, Granulomatous | 2 2 | 2 2.0|
Fat, Necrosis | 3 3 2 3 2 | 8 2.6|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 2 1 2 1 2 2 1 1 1 | 16 1.4|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal, Squamous | 2 | 1 2.0|
Ulcer | | 1 3.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 | 1 1.0|
Ulcer | | 2 2.0|
Epithelium, Hyperplasia, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrium, Thrombosis | 2 | 1 2.0|
Myocardium, Degeneration | 2 1 2 2 1 1 2 2 3 3 1 2 2 1 2 1 3 3 1 2 3| 41 2.0|
Vein, Thrombosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 7| 7| 7| 6| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 6| 7| 7| |
DAY ON TEST | 2| 2| 6| 2| 8| 2| 2| 2| 7| 6| 3| 2| 2| 2| 2| 2| 2| 2| 2| 5| 2| 6| 0| 2| 2| |
| 0| 8| 1| 9| 4| 7| 8| 8| 9| 1| 7| 7| 8| 9| 9| 7| 7| 7| 8| 6| 7| 0| 4| 7| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
126 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 1 1 2 1 1 1 2| 17 1.6|
Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 1 2 2 1 1 2 1 | 13 1.6|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 2 1.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + M M + + + + + + + + + + M + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 1.0|
Cyst | 4 1 | 2 2.5|
Hyperplasia | 3 3| 2 3.0|
Necrosis, Focal | | 1 3.0|
Pars Distalis, Hyperplasia, Focal | 1 1 1 2 1 2 | 9 1.2|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 4 3 1 2 3 3 2 2 3 2 2 2 2 2 2 2 1 2 2| 35 2.1|
Follicle, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
Inflammation, Chronic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 3.0|
Granuloma Sperm | | 1 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 7| 7| 7| 6| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 6| 7| 7| |
DAY ON TEST | 2| 2| 6| 2| 8| 2| 2| 2| 7| 6| 3| 2| 2| 2| 2| 2| 2| 2| 2| 5| 2| 6| 0| 2| 2| |
| 0| 8| 1| 9| 4| 7| 8| 8| 9| 1| 7| 7| 8| 9| 9| 7| 7| 7| 8| 6| 7| 0| 4| 7| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
126 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Inflammation, Acute | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 2 2.5|
Inflammation, Chronic | 1 1 2 1 1 2 2 1 1 1 1 2 2 2 1 1 2 2 2| 37 1.5|
Inflammation, Suppurative | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 3 1 1 1 1 1 2 1 2 | 18 1.4|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 2 2.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Germinal Epithelium, Atrophy | | 1 4.0|
Interstitial Cell, Hyperplasia | | 2 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + +| 13 |
Deep Cervical, Angiectasis | | 1 3.0|
Mediastinal, Angiectasis | | 1 2.0|
Mediastinal, Ectasia | 1 | 1 1.0|
Mediastinal, Hemorrhage | 2 | 1 2.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 1.0|
Mediastinal, Hyperplasia, Plasma Cell| 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M| 2 |
Ectasia | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 7| 7| 7| 6| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 6| 7| 7| |
DAY ON TEST | 2| 2| 6| 2| 8| 2| 2| 2| 7| 6| 3| 2| 2| 2| 2| 2| 2| 2| 2| 5| 2| 6| 0| 2| 2| |
| 0| 8| 1| 9| 4| 7| 8| 8| 9| 1| 7| 7| 8| 9| 9| 7| 7| 7| 8| 6| 7| 0| 4| 7| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
126 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Hemorrhage | 1 | 1 1.0|
Hyperplasia, Lymphoid | | 1 3.0|
Infiltration Cellular, Histiocyte | 1 1 2 1 1 1 1 2 2 2 1 1 1 2 1 1 1 2 1 3 2 | 39 1.5|
Inflammation, Granulomatous | 2 2 | 3 1.7|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Focal | 1 | 1 1.0|
Hematopoietic Cell Proliferation | 1 | 4 1.3|
Hyperplasia, Lymphohistiocytic | 3 2 | 8 2.8|
Capsule, Fibrosis, Focal | | 1 1.0|
Lymphoid Follicle, Atrophy | 2 2 2 1 4 2 3 2 2 2 4 2 | 25 2.4|
|__________________________________________________________________________|____________|
Thymus | M M + + M + + + + + + + + + + + + + + + + + + + +| 43 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 1 1 1 1 1 1 1 1 1 | 17 1.2|
Duct, Dilatation | 1 1 2 2 1 2 1 | 15 1.5|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Sebaceous Gland, Hyperplasia, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
Hemorrhage | | 1 4.0|
Inflammation, Acute | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 93
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 7| 7| 7| 6| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 6| 7| 7| |
DAY ON TEST | 2| 2| 6| 2| 8| 2| 2| 2| 7| 6| 3| 2| 2| 2| 2| 2| 2| 2| 2| 5| 2| 6| 0| 2| 2| |
| 0| 8| 1| 9| 4| 7| 8| 8| 9| 1| 7| 7| 8| 9| 9| 7| 7| 7| 8| 6| 7| 0| 4| 7| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
126 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
Hydrocephalus | 2 1 | 6 2.7|
Hypothalamus, Compression | | 4 3.3|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + | 1 |
Hemorrhage | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 4 3.5|
Infiltration Cellular, Histiocyte | | 1 3.0|
Myxomatous Change | | 1 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 | 3 2.0|
Alveolar Epithelium, Hyperplasia | 1 | 1 1.0|
Alveolar Epithelium, Metaplasia, | | |
Squamous | 1 | 2 1.0|
Alveolus, Emphysema, Focal | 2 | 1 2.0|
Alveolus, Inflammation, Acute | | 2 3.0|
Alveolus, Inflammation, Chronic | | |
Active, Focal | 1 1 2 2 1 1 1 3 | 14 1.6|
Artery, Thrombosis | | 1 4.0|
Interstitium, Fibrosis, Focal | | 1 1.0|
Interstitium, Alveolus, Inflammation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 1 1 1 | 9 1.3|
Thrombosis | | 1 3.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
Inflammation, Chronic | | 4 1.5|
Ulcer | | 1 2.0|
Epithelium, Metaplasia, Squamous | | 1 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 94
NTP Experiment-Test: 88122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ELMIRON Date: 06/12/01
Route: GAVAGE Time: 09:22:58
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 7| 7| 7| 6| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 6| 7| 7| |
DAY ON TEST | 2| 2| 6| 2| 8| 2| 2| 2| 7| 6| 3| 2| 2| 2| 2| 2| 2| 2| 2| 5| 2| 6| 0| 2| 2| |
| 0| 8| 1| 9| 4| 7| 8| 8| 9| 1| 7| 7| 8| 9| 9| 7| 7| 7| 8| 6| 7| 0| 4| 7| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
126 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + | 1 |
Cataract | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy | 1 1 1 1 1 1 1 1 2 2 1 3 1 1 2 1 2 2 2 1 1 3| 37 1.5|
|__________________________________________________________________________|____________|
Urethra | + | 1 |
Inflammation, Suppurative | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 95
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