TDMS Study 88122-07 Pathology Tables
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 FINAL#1/MICE Facility: Battelle Columbus Laboratory Chemical CAS #: 37319-17-8 Lock Date: 04/14/00 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 8| 3| 2| 3| 5| 2| 2| 2| 2| 3| 3| 6| 3| 3| 2| 3| 2| 3| 2| 3| 3| 2| 3| 3| | 9| 5| 0| 9| 0| 6| 9| 9| 9| 9| 0| 6| 7| 0| 0| 9| 0| 9| 0| 9| 0| 0| 9| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | + A + + I + + + + + + A A + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + A + + + + + + + + + A A + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + A + + + + + + + + + A A + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + A + + + + + + + + + A A + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + A + + + + + + + + + A A + + + I + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + A A + + + + + + + + + + + +| Carcinoma | | Lymphoma Malignant | X X | |__________________________________________________________________________| Intestine Small, Ileum | + A + + + + + + + + + A A + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Hepatocellular Carcinoma | X | Hepatocellular Adenoma | X X X X X X | Hepatocellular Adenoma, Multiple | | Lymphoma Malignant | X | Sarcoma, Metastatic, Skin | | |__________________________________________________________________________| Mesentery | + + + + + + + + + + + + + | Sarcoma, Metastatic, Skin | | Sarcoma, Metastatic, Uterus | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + A + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X | __________________________________________|__________________________________________________________________________| Page 2 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 8| 3| 2| 3| 5| 2| 2| 2| 2| 3| 3| 6| 3| 3| 2| 3| 2| 3| 2| 3| 3| 2| 3| 3| | 9| 5| 0| 9| 0| 6| 9| 9| 9| 9| 0| 6| 7| 0| 0| 9| 0| 9| 0| 9| 0| 0| 9| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + A + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + A + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + A + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + A + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + A + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + M M + + + + M + + + M + M + + + + + M + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X | |__________________________________________________________________________| Thyroid Gland | + A + + + + + + + + + A + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + M M + + + + + M + + + M + + M + + M + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + M + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 3 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 8| 3| 2| 3| 5| 2| 2| 2| 2| 3| 3| 6| 3| 3| 2| 3| 2| 3| 2| 3| 3| 2| 3| 3| | 9| 5| 0| 9| 0| 6| 9| 9| 9| 9| 0| 6| 7| 0| 0| 9| 0| 9| 0| 9| 0| 0| 9| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | Cystadenoma | | Lymphoma Malignant | X | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Polyp Stromal | X X | Sarcoma | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X | |__________________________________________________________________________| Lymph Node | + + + | Bronchial, Lymphoma Malignant | X | Inguinal, Lymphoma Malignant | X | Lumbar, Lymphoma Malignant | | Mediastinal, Lymphoma Malignant | X X | Mediastinal, Sarcoma, Metastatic, | | Skin | | Pancreatic, Lymphoma Malignant | X | Pancreatic, Sarcoma, Metastatic, Skin| | Renal, Lymphoma Malignant | | |__________________________________________________________________________| Lymph Node, Mandibular | + M + M + + + M M + + + + + + + + + + M + + + + M| Lymphoma Malignant | X X | |__________________________________________________________________________| Lymph Node, Mesenteric | + A + + + + + + + + + + A + + + + + + + + + + + +| Lymphoma Malignant | X X X X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + A A + + + + + + + + + + + +| Lymphoma Malignant | X X X X | |__________________________________________________________________________| Thymus | M + + + + + + + + + + + + + + + + M + + + + + + M| Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | __________________________________________|__________________________________________________________________________| Page 4 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 8| 3| 2| 3| 5| 2| 2| 2| 2| 3| 3| 6| 3| 3| 2| 3| 2| 3| 2| 3| 3| 2| 3| 3| | 9| 5| 0| 9| 0| 6| 9| 9| 9| 9| 0| 6| 7| 0| 0| 9| 0| 9| 0| 9| 0| 0| 9| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | X | Subcutaneous Tissue, Sarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | X | |__________________________________________________________________________| Skeletal Muscle | + | Sarcoma, Metastatic, Uterus | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Oligodendroglioma Benign | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Alveolar/Bronchiolar Carcinoma | | Hepatocellular Carcinoma, Metastatic,| | Liver | | Lymphoma Malignant | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + A + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 5 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 8| 3| 2| 3| 5| 2| 2| 2| 2| 3| 3| 6| 3| 3| 2| 3| 2| 3| 2| 3| 3| 2| 3| 3| | 9| 5| 0| 9| 0| 6| 9| 9| 9| 9| 0| 6| 7| 0| 0| 9| 0| 9| 0| 9| 0| 0| 9| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Adenoma | X X | Bilateral, Adenoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + A + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Urinary Bladder | + A + + + + + + + + + A A + + + + + + + + + + + +| Lymphoma Malignant | X X | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X X X X X | __________________________________________|__________________________________________________________________________| Page 6 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 1| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | DAY ON TEST | 6| 2| 2| 4| 0| 2| 2| 2| 3| 1| 3| 1| 8| 3| 8| 3| 2| 2| 3| 2| 3| 3| 3| 2| 3| | | 1| 9| 9| 7| 3| 9| 9| 9| 0| 7| 0| 1| 3| 0| 3| 0| 3| 9| 0| 9| 0| 0| 0| 9| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Gallbladder | + + + + + + + + + M + + A + A + A + M + + I + + A| 39 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + A + + + + + + + + + + + + A + + + + + + + +| 45 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + A + + + + + + + + + + + + A + + + + + + + +| 45 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + A I + + + + + + + A + A + A + + + + + + + A| 41 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + A + + + + + + + + A + A + A + + + + + + + A| 41 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + A + + + + + + + + A + A + A + + + + + + + A| 43 | Carcinoma | X | 1 | Lymphoma Malignant | | 2 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + A + + + + + + + + A + A + A + + + + + + + A| 42 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | | 1 | Hepatocellular Carcinoma | X X | 3 | Hepatocellular Adenoma | | 6 | Hepatocellular Adenoma, Multiple | X | 1 | Lymphoma Malignant | X | 2 | Sarcoma, Metastatic, Skin | X | 1 | |__________________________________________________________________________|____________| Mesentery | + + + + + + + + + + + + + + + + +| 30 | Sarcoma, Metastatic, Skin | X | 1 | Sarcoma, Metastatic, Uterus | X | 1 | |__________________________________________________________________________|____________| Pancreas | + + + A + + + + + + + + A + + + A + + + + + + + +| 46 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 7 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 1| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | DAY ON TEST | 6| 2| 2| 4| 0| 2| 2| 2| 3| 1| 3| 1| 8| 3| 8| 3| 2| 2| 3| 2| 3| 3| 3| 2| 3| | | 1| 9| 9| 7| 3| 9| 9| 9| 0| 7| 0| 1| 3| 0| 3| 0| 3| 9| 0| 9| 0| 0| 0| 9| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 | Lymphoma Malignant | | 2 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + A + + + A + + + + + + + +| 47 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + A + + + + + + + + A + + + A + + + + + + + +| 46 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | +| 2 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + A + + + + + + + + A + + + A + + + + + + + +| 46 | |__________________________________________________________________________|____________| Parathyroid Gland | M M + + I + + + + + + + M + + + M + + + + + I M +| 37 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + M| 48 | Pars Distalis, Adenoma | X | 2 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + A + + + A + + + + + + + +| 46 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 8 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 1| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | DAY ON TEST | 6| 2| 2| 4| 0| 2| 2| 2| 3| 1| 3| 1| 8| 3| 8| 3| 2| 2| 3| 2| 3| 3| 3| 2| 3| | | 1| 9| 9| 7| 3| 9| 9| 9| 0| 7| 0| 1| 3| 0| 3| 0| 3| 9| 0| 9| 0| 0| 0| 9| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | M + + + + + + + + + + + M I + + + M + + + + + M +| 39 | |__________________________________________________________________________|____________| Ovary | + + + + M + + + + + + + + + + + + + + + I + + + +| 47 | Cystadenoma | X | 1 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + A + + + A + + + + + + + +| 48 | Polyp Stromal | X | 3 | Sarcoma | X | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 2 | |__________________________________________________________________________|____________| Lymph Node | + + + | 6 | Bronchial, Lymphoma Malignant | | 1 | Inguinal, Lymphoma Malignant | | 1 | Lumbar, Lymphoma Malignant | X | 1 | Mediastinal, Lymphoma Malignant | X | 3 | Mediastinal, Sarcoma, Metastatic, | | | Skin | X | 1 | Pancreatic, Lymphoma Malignant | | 1 | Pancreatic, Sarcoma, Metastatic, Skin| X | 1 | Renal, Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + M + + M M + + M + M + M + M M + M + M + + + + M| 33 | Lymphoma Malignant | X | 3 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + + + + + + + +| 47 | Lymphoma Malignant | X | 5 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 9 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 1| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | DAY ON TEST | 6| 2| 2| 4| 0| 2| 2| 2| 3| 1| 3| 1| 8| 3| 8| 3| 2| 2| 3| 2| 3| 3| 3| 2| 3| | | 1| 9| 9| 7| 3| 9| 9| 9| 0| 7| 0| 1| 3| 0| 3| 0| 3| 9| 0| 9| 0| 0| 0| 9| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Spleen | + + + + + + + + + + + + A + + + + + + + + + + + +| 47 | Lymphoma Malignant | X | 5 | |__________________________________________________________________________|____________| Thymus | + + + + M + + + + + + + + M + + A + + + + + + + M| 43 | Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basal Cell Adenoma | | 1 | Subcutaneous Tissue, Sarcoma | X X X | 3 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteosarcoma | | 1 | |__________________________________________________________________________|____________| Skeletal Muscle | + | 2 | Sarcoma, Metastatic, Uterus | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Oligodendroglioma Benign | X| 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X | 2 | Alveolar/Bronchiolar Carcinoma | X | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 10 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 1| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | DAY ON TEST | 6| 2| 2| 4| 0| 2| 2| 2| 3| 1| 3| 1| 8| 3| 8| 3| 2| 2| 3| 2| 3| 3| 3| 2| 3| | | 1| 9| 9| 7| 3| 9| 9| 9| 0| 7| 0| 1| 3| 0| 3| 0| 3| 9| 0| 9| 0| 0| 0| 9| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 1 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + A + + + A + + + + + + + A| 46 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 | Adenoma | X | 3 | Bilateral, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + A + + + + + + + + + + + +| 48 | Lymphoma Malignant | X | 2 | |__________________________________________________________________________|____________| Urinary Bladder | + + + A + + + + + + + + A + + + A + + + + + + + M| 43 | Lymphoma Malignant | | 2 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X | 7 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 11 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 2| 2| 2| 0| 3| 3| 3| 2| 3| 2| 3| 2| 2| 3| 2| 8| 2| 2| 8| 2| 2| 3| 3| 3| | 0| 9| 9| 9| 3| 0| 0| 0| 9| 0| 9| 0| 9| 9| 0| 9| 1| 9| 9| 1| 9| 2| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 56 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + M M + + A + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + A + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + A + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + A + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + A + + +| Polyp Adenomatous | X X | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + A + + +| Lymphoma Malignant | X| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + A + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Hepatocellular Carcinoma | X X | Hepatocellular Adenoma | X | Hepatocellular Adenoma, Multiple | | Histiocytic Sarcoma | X | Lymphoma Malignant | | |__________________________________________________________________________| Mesentery | + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Sarcoma | | Sarcoma, Metastatic, Skin | X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + A + + +| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + M + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + A + + +| __________________________________________|__________________________________________________________________________| Page 12 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 2| 2| 2| 0| 3| 3| 3| 2| 3| 2| 3| 2| 2| 3| 2| 8| 2| 2| 8| 2| 2| 3| 3| 3| | 0| 9| 9| 9| 3| 0| 0| 0| 9| 0| 9| 0| 9| 9| 0| 9| 1| 9| 9| 1| 9| 2| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 56 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + A + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Pericardium, Alveolar/Bronchiolar | | Carcinoma, Metastatic, Lung | X | Pericardium, Sarcoma | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + A + + +| Histiocytic Sarcoma | | Lymphoma Malignant | | Sarcoma, Metastatic, Skin | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + A + + +| Lymphoma Malignant | | Pheochromocytoma Benign | | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + A + + +| |__________________________________________________________________________| Parathyroid Gland | + + M + M M + + + + + + + M + + + M + + M M + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + M M + +| Pars Distalis, Adenoma | X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + M + + + M + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Tissue NOS | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | __________________________________________|__________________________________________________________________________| Page 13 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 2| 2| 2| 0| 3| 3| 3| 2| 3| 2| 3| 2| 2| 3| 2| 8| 2| 2| 8| 2| 2| 3| 3| 3| | 0| 9| 9| 9| 3| 0| 0| 0| 9| 0| 9| 0| 9| 9| 0| 9| 1| 9| 9| 1| 9| 2| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 56 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | |__________________________________________________________________________| Clitoral Gland | + + I + + M + + + + + + + + + + + + + + + M + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + I + + + + + + + + +| Cystadenoma | X | Histiocytic Sarcoma | | Luteoma | | Lymphoma Malignant | | Sarcoma, Metastatic, Mesentery | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + A + + +| Histiocytic Sarcoma | X | Polyp Stromal | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + A + + +| Hemangiosarcoma | | Histiocytic Sarcoma | X | |__________________________________________________________________________| Lymph Node | + + +| Bronchial, Histiocytic Sarcoma | X | Bronchial, Lymphoma Malignant | | Lumbar, Histiocytic Sarcoma | | Mediastinal, Histiocytic Sarcoma | X | Mediastinal, Lymphoma Malignant | | Pancreatic, Lymphoma Malignant | X| Renal, Sarcoma, Metastatic, Skin | | |__________________________________________________________________________| Lymph Node, Mandibular | + M + + M + M + M + M + + + M + + + + + + M + M +| Histiocytic Sarcoma | | Lymphoma Malignant | | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + A + + +| Histiocytic Sarcoma | X | Lymphoma Malignant | X| __________________________________________|__________________________________________________________________________| Page 14 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 2| 2| 2| 0| 3| 3| 3| 2| 3| 2| 3| 2| 2| 3| 2| 8| 2| 2| 8| 2| 2| 3| 3| 3| | 0| 9| 9| 9| 3| 0| 0| 0| 9| 0| 9| 0| 9| 9| 0| 9| 1| 9| 9| 1| 9| 2| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 56 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Sarcoma, Metastatic, Mesentery | | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + A + + +| Hemangiosarcoma | | Histiocytic Sarcoma | | Lymphoma Malignant | X | |__________________________________________________________________________| Thymus | M M M + + + + + + M + M M + + + + + + M + M + + +| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Histiocytic | | Sarcoma | | Subcutaneous Tissue, Sarcoma | X X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + M + + +| Histiocytic Sarcoma | X | Lymphoma Malignant | | Sarcoma | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Adenoma, | | Multiple | | __________________________________________|__________________________________________________________________________| Page 15 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 2| 2| 2| 0| 3| 3| 3| 2| 3| 2| 3| 2| 2| 3| 2| 8| 2| 2| 8| 2| 2| 3| 3| 3| | 0| 9| 9| 9| 3| 0| 0| 0| 9| 0| 9| 0| 9| 9| 0| 9| 1| 9| 9| 1| 9| 2| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 56 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Alveolar/Bronchiolar Carcinoma | X | Histiocytic Sarcoma | X | Lymphoma Malignant | | Sarcoma | X | Sarcoma, Metastatic, Skin | X X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | |__________________________________________________________________________| Pleura | + | Sarcoma, Metastatic, Lung | X | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + A + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X | Carcinoma | | Lymphoma Malignant | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X X | Lymphoma Malignant | X | Sarcoma, Metastatic, Mesentery | | Sarcoma, Metastatic, Skin | X | Transitional Epithelium, Carcinoma | X | |__________________________________________________________________________| Ureter | | |__________________________________________________________________________| Urethra | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + A + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 16 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________|__________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 2| 2| 2| 0| 3| 3| 3| 2| 3| 2| 3| 2| 2| 3| 2| 8| 2| 2| 8| 2| 2| 3| 3| 3| | 0| 9| 9| 9| 3| 0| 0| 0| 9| 0| 9| 0| 9| 9| 0| 9| 1| 9| 9| 1| 9| 2| 0| 0| 0| _____________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 56 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | Histiocytic Sarcoma | X X | Lymphoma Malignant | X X| __________________________________________|__________________________________________________________________________| Page 17 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 4| 7| 0| 7| 7| 7| 7| 7| 5| 2| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 2| 5| 8| 3| 1| 3| 2| 2| 3| 2| 4| 8| 2| 3| 3| 2| 2| 1| 4| 2| 0| 2| | | 0| 0| 0| 9| 5| 5| 0| 8| 0| 9| 9| 0| 9| 1| 1| 9| 0| 0| 9| 9| 1| 2| 9| 3| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 56 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Gallbladder | + + + + + A A + + + + + + A A + + + + + A A + M +| 40 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + A A + + + + + + A A + + + + + + A + + +| 44 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + A A + + + + + + + A + + + + + + A + + +| 45 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + A A + + + + + + A A + + + + + A A + + +| 43 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + A A + + + + + + A A + + + + + + A + + +| 44 | Polyp Adenomatous | | 2 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + A A + + + + + + A A + + + + + + A + + +| 44 | Lymphoma Malignant | X | 2 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + A A + + + + + + A A + + + + + + A + + +| 44 | |__________________________________________________________________________|____________| Liver | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 | Hemangiosarcoma | X | 1 | Hepatocellular Carcinoma | X| 3 | Hepatocellular Adenoma | X X | 3 | Hepatocellular Adenoma, Multiple | X X | 2 | Histiocytic Sarcoma | X X | 3 | Lymphoma Malignant | X X X | 3 | |__________________________________________________________________________|____________| Mesentery | + + + + + + + + + + + + + + + + +| 34 | Histiocytic Sarcoma | X | 1 | Sarcoma | X | 1 | Sarcoma, Metastatic, Skin | X | 2 | |__________________________________________________________________________|____________| Pancreas | + + + + + A A + + + + + + + A + + + + + + A + + +| 45 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 18 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 4| 7| 0| 7| 7| 7| 7| 7| 5| 2| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 2| 5| 8| 3| 1| 3| 2| 2| 3| 2| 4| 8| 2| 3| 3| 2| 2| 1| 4| 2| 0| 2| | | 0| 0| 0| 9| 5| 5| 0| 8| 0| 9| 9| 0| 9| 1| 1| 9| 0| 0| 9| 9| 1| 2| 9| 3| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 56 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + A + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + A A + + + + + + + A + + + + + + A + + +| 45 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Pericardium, Alveolar/Bronchiolar | | | Carcinoma, Metastatic, Lung | | 1 | Pericardium, Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X | 1 | Sarcoma, Metastatic, Skin | X | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant | X | 1 | Pheochromocytoma Benign | X | 1 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + A A + + + + + + + A + + + + + + A + + +| 45 | |__________________________________________________________________________|____________| Parathyroid Gland | + M + + + + + M + + + + + + M M + + + + A + + + +| 38 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Pars Distalis, Adenoma | X X | 3 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 19 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 4| 7| 0| 7| 7| 7| 7| 7| 5| 2| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 2| 5| 8| 3| 1| 3| 2| 2| 3| 2| 4| 8| 2| 3| 3| 2| 2| 1| 4| 2| 0| 2| | | 0| 0| 0| 9| 5| 5| 0| 8| 0| 9| 9| 0| 9| 1| 1| 9| 0| 0| 9| 9| 1| 2| 9| 3| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 56 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Tissue NOS | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + M + + + + + + + M + M + + + + + + +| 44 | |__________________________________________________________________________|____________| Ovary | + + + + + + A + + + + + + + + + + + + + + A + + I| 46 | Cystadenoma | | 1 | Histiocytic Sarcoma | X | 1 | Luteoma | X | 1 | Lymphoma Malignant | X | 1 | Sarcoma, Metastatic, Mesentery | X | 1 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Histiocytic Sarcoma | X | 2 | Polyp Stromal | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 | Hemangiosarcoma | X | 1 | Histiocytic Sarcoma | | 1 | |__________________________________________________________________________|____________| Lymph Node | + + + + + + + | 10 | Bronchial, Histiocytic Sarcoma | X | 2 | Bronchial, Lymphoma Malignant | X X X | 3 | Lumbar, Histiocytic Sarcoma | X | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 20 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 4| 7| 0| 7| 7| 7| 7| 7| 5| 2| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 2| 5| 8| 3| 1| 3| 2| 2| 3| 2| 4| 8| 2| 3| 3| 2| 2| 1| 4| 2| 0| 2| | | 0| 0| 0| 9| 5| 5| 0| 8| 0| 9| 9| 0| 9| 1| 1| 9| 0| 0| 9| 9| 1| 2| 9| 3| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 56 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Mediastinal, Histiocytic Sarcoma | X | 2 | Mediastinal, Lymphoma Malignant | X | 1 | Pancreatic, Lymphoma Malignant | X X | 3 | Renal, Sarcoma, Metastatic, Skin | X | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + M M + M + + A + + + + + + + + + +| 38 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X X X | 3 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + A A + + + + + + M A + + + + + + A + + +| 44 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X X | 3 | Sarcoma, Metastatic, Mesentery | X | 1 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + A + + +| 48 | Hemangiosarcoma | X | 1 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X X X X X | 6 | |__________________________________________________________________________|____________| Thymus | + + + + + + A + + + + + + + + M + + + M + + + + M| 38 | Lymphoma Malignant | X X | 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Histiocytic | | | Sarcoma | X | 1 | Subcutaneous Tissue, Sarcoma | X X | 4 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 21 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 4| 7| 0| 7| 7| 7| 7| 7| 5| 2| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 2| 5| 8| 3| 1| 3| 2| 2| 3| 2| 4| 8| 2| 3| 3| 2| 2| 1| 4| 2| 0| 2| | | 0| 0| 0| 9| 5| 5| 0| 8| 0| 9| 9| 0| 9| 1| 1| 9| 0| 0| 9| 9| 1| 2| 9| 3| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 56 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| MUSCULOSKELETAL SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Histiocytic Sarcoma | X | 2 | Lymphoma Malignant | X | 1 | Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | | 2 | Alveolar/Bronchiolar Adenoma, | | | Multiple | X | 1 | Alveolar/Bronchiolar Carcinoma | | 1 | Histiocytic Sarcoma | X X | 3 | Lymphoma Malignant | X X X | 3 | Sarcoma | | 1 | Sarcoma, Metastatic, Skin | X | 3 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 1 | |__________________________________________________________________________|____________| Pleura | | 1 | Sarcoma, Metastatic, Lung | | 1 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 22 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 4| 7| 0| 7| 7| 7| 7| 7| 5| 2| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 2| 5| 8| 3| 1| 3| 2| 2| 3| 2| 4| 8| 2| 3| 3| 2| 2| 1| 4| 2| 0| 2| | | 0| 0| 0| 9| 5| 5| 0| 8| 0| 9| 9| 0| 9| 1| 1| 9| 0| 0| 9| 9| 1| 2| 9| 3| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 56 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | | | | Harderian Gland | + + + + + + + + + + + + + + + M M M M + M M M M M| 41 | Adenoma | | 3 | Carcinoma | X X | 2 | Lymphoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 | Histiocytic Sarcoma | X X | 4 | Lymphoma Malignant | X X | 3 | Sarcoma, Metastatic, Mesentery | X | 1 | Sarcoma, Metastatic, Skin | | 1 | Transitional Epithelium, Carcinoma | | 1 | |__________________________________________________________________________|____________| Ureter | A | | |__________________________________________________________________________|____________| Urethra | + | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + A + + + + + + + A + + + + + + A + + +| 46 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X X | 4 | Lymphoma Malignant | X X X X X X | 8 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 23 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 _____________________________________________________________________________________________________________________ | 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| DAY ON TEST | 2| 2| 1| 2| 2| 3| 3| 2| 3| 3| 3| 3| 8| 3| 2| 3| 3| 2| 1| 3| 3| 0| 3| 3| 3| | 9| 9| 3| 9| 9| 0| 8| 9| 0| 0| 0| 0| 1| 0| 9| 0| 8| 9| 7| 0| 0| 3| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 168 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | + + + + + + + + + M + + + M + + A M A + + A + + +| Lymphoma Malignant | | Sarcoma, Metastatic, Uterus | X | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + A + + + + + + + + + A + A + + A + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + A + + + + + + + + + A + A + + A + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + A + + + + + + + + + A + A + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + A + + + + + + + + + A + A + + A + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + A + + + + + + + + + A + A + + A + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + A + + + + + + + + + A + A + + A + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Hepatocellular Carcinoma | X | Hepatocellular Adenoma | | Hepatocellular Adenoma, Multiple | X | Histiocytic Sarcoma | X | Lymphoma Malignant | | Osteosarcoma, Metastatic, Uncertain | | Primary Site | | Sarcoma, Metastatic, Skin | X X | Sarcoma, Metastatic, Uterus | X | |__________________________________________________________________________| Mesentery | + + + + + + + + + + + + + + +| Sarcoma, Metastatic, Skin | X X | Sarcoma, Metastatic, Uterus | X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + A + + + + A + + +| __________________________________________|__________________________________________________________________________| Page 24 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 _____________________________________________________________________________________________________________________ | 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| DAY ON TEST | 2| 2| 1| 2| 2| 3| 3| 2| 3| 3| 3| 3| 8| 3| 2| 3| 3| 2| 1| 3| 3| 0| 3| 3| 3| | 9| 9| 3| 9| 9| 0| 8| 9| 0| 0| 0| 0| 1| 0| 9| 0| 8| 9| 7| 0| 0| 3| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 168 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Lymphoma Malignant | | Sarcoma, Metastatic, Skin | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma, Metastatic, Skin | X | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + A + A + + A + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + A + + +| Subcapsular, Carcinoma | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + M + M + + A + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + A + A + + A + + +| |__________________________________________________________________________| Parathyroid Gland | + M + + + + I + + + + M + M I + + + M + + M + M +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + I + A + + + + + +| Pars Distalis, Adenoma | X X X | Pars Intermedia, Adenoma | | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Peritoneum | + | Sarcoma, Metastatic, Skin | X | _____________________________________________________________________________________________________________________| Page 25 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 _____________________________________________________________________________________________________________________ | 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| DAY ON TEST | 2| 2| 1| 2| 2| 3| 3| 2| 3| 3| 3| 3| 8| 3| 2| 3| 3| 2| 1| 3| 3| 0| 3| 3| 3| | 9| 9| 3| 9| 9| 0| 8| 9| 0| 0| 0| 0| 1| 0| 9| 0| 8| 9| 7| 0| 0| 3| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 168 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + M I + + + M + + + + + I + + + + + + M + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + A + + + + + +| Cystadenoma | X | Hemangiosarcoma | | Lymphoma Malignant | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Polyp Stromal | X | Sarcoma | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant | | |__________________________________________________________________________| Lymph Node | + | Bronchial, Lymphoma Malignant | | Bronchial, Osteosarcoma, Metastatic, | | Uncertain Primary Site | | Mediastinal, Lymphoma Malignant | | Mediastinal, Osteosarcoma, | | Metastatic, Uncertain Primary | | Site | | Renal, Lymphoma Malignant | | |__________________________________________________________________________| Lymph Node, Mandibular | M + M M + + + + + + + + + + + + M + M + + + + M +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + A + + + + + M + + + A + A + + A + + +| Lymphoma Malignant | | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + A + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 26 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 _____________________________________________________________________________________________________________________ | 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| DAY ON TEST | 2| 2| 1| 2| 2| 3| 3| 2| 3| 3| 3| 3| 8| 3| 2| 3| 3| 2| 1| 3| 3| 0| 3| 3| 3| | 9| 9| 3| 9| 9| 0| 8| 9| 0| 0| 0| 0| 1| 0| 9| 0| 8| 9| 7| 0| 0| 3| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 168 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Thymus | + + + + + + M + + + + + + + M + + M A I + A + + +| Lymphoma Malignant | | Osteosarcoma, Metastatic, Uncertain | | Primary Site | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma, Metastatic, Uterus | X | Subcutaneous Tissue, Hemangiosarcoma | | Subcutaneous Tissue, Lymphoma | | Malignant | | Subcutaneous Tissue, Sarcoma | X X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Harderian | | Gland | | |__________________________________________________________________________| Skeletal Muscle | | Osteosarcoma, Metastatic, Uncertain | | Primary Site | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Alveolar/Bronchiolar Carcinoma | X | Carcinoma, Metastatic, Harderian | | __________________________________________|__________________________________________________________________________| Page 27 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 _____________________________________________________________________________________________________________________ | 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| DAY ON TEST | 2| 2| 1| 2| 2| 3| 3| 2| 3| 3| 3| 3| 8| 3| 2| 3| 3| 2| 1| 3| 3| 0| 3| 3| 3| | 9| 9| 3| 9| 9| 0| 8| 9| 0| 0| 0| 0| 1| 0| 9| 0| 8| 9| 7| 0| 0| 3| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 168 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Gland | | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Histiocytic Sarcoma | X | Lymphoma Malignant | | Osteosarcoma, Metastatic, Uncertain | | Primary Site | | Sarcoma, Metastatic, Skin | X X | Mediastinum, Osteosarcoma, | | Metastatic, Uncertain Primary | | Site | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + A + + A + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + A + + A + + +| Histiocytic Sarcoma | X | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + A + + A + + +| Lymphoma Malignant | | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant | X | __________________________________________|__________________________________________________________________________| Page 28 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| | DAY ON TEST | 3| 0| 3| 4| 2| 2| 3| 2| 2| 8| 3| 2| 6| 7| 3| 2| 3| 3| 5| 2| 3| 2| 2| 2| 2| | | 0| 9| 0| 7| 9| 9| 0| 9| 9| 9| 0| 9| 7| 7| 0| 9| 0| 0| 3| 9| 0| 9| 1| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 168 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Gallbladder | + + + A I + + + + M + + A A + + + + + + + + A + +| 38 | Lymphoma Malignant | X | 1 | Sarcoma, Metastatic, Uterus | | 1 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + A A + + + + + + + + + + +| 44 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + A A + + + + + + + + + + +| 44 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + A + + + + + + + + A A + + + + + + + + + + +| 44 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + A + + + + + + + + A A + + + + + + + + A + +| 42 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + A + + + + + + + + A A + + + + + + + + A + +| 42 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + A + + + + + + + + A A + + + + + + + + A + +| 42 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | | 1 | Hepatocellular Carcinoma | X X X X | 5 | Hepatocellular Adenoma | X X | 2 | Hepatocellular Adenoma, Multiple | X | 2 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X X X | 3 | Osteosarcoma, Metastatic, Uncertain | | | Primary Site | X | 1 | Sarcoma, Metastatic, Skin | | 2 | Sarcoma, Metastatic, Uterus | | 1 | |__________________________________________________________________________|____________| Mesentery | + + + + + + + + + + + + + + + + +| 32 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 29 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| | DAY ON TEST | 3| 0| 3| 4| 2| 2| 3| 2| 2| 8| 3| 2| 6| 7| 3| 2| 3| 3| 5| 2| 3| 2| 2| 2| 2| | | 0| 9| 0| 7| 9| 9| 0| 9| 9| 9| 0| 9| 7| 7| 0| 9| 0| 0| 3| 9| 0| 9| 1| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 168 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Sarcoma, Metastatic, Skin | | 2 | Sarcoma, Metastatic, Uterus | | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + A M + + + + + + + + + + +| 46 | Lymphoma Malignant | X | 1 | Sarcoma, Metastatic, Skin | | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 | Sarcoma, Metastatic, Skin | | 1 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + A A + + + + + + + + A + +| 44 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Subcapsular, Carcinoma | X| 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + A M + + + + + + + + + + +| 45 | |__________________________________________________________________________|____________| Parathyroid Gland | M + M + + M + + + + + + M + M + + + + + + + + + +| 37 | |__________________________________________________________________________|____________| Pituitary Gland | + I + I + + M + + + + + + + + + + + + + + + + + +| 45 | Pars Distalis, Adenoma | X | 4 | Pars Intermedia, Adenoma | X | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 30 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| | DAY ON TEST | 3| 0| 3| 4| 2| 2| 3| 2| 2| 8| 3| 2| 6| 7| 3| 2| 3| 3| 5| 2| 3| 2| 2| 2| 2| | | 0| 9| 0| 7| 9| 9| 0| 9| 9| 9| 0| 9| 7| 7| 0| 9| 0| 0| 3| 9| 0| 9| 1| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 168 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Peritoneum | | 1 | Sarcoma, Metastatic, Skin | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + M + + + + + + + + M + + + I + + + + + + + + + +| 42 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + A + + + + + + + I + + + +| 47 | Cystadenoma | X | 2 | Hemangiosarcoma | X | 1 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Polyp Stromal | X | 2 | Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Lymph Node | + + + + | 5 | Bronchial, Lymphoma Malignant | X X | 2 | Bronchial, Osteosarcoma, Metastatic, | | | Uncertain Primary Site | X | 1 | Mediastinal, Lymphoma Malignant | X X | 2 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 31 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| | DAY ON TEST | 3| 0| 3| 4| 2| 2| 3| 2| 2| 8| 3| 2| 6| 7| 3| 2| 3| 3| 5| 2| 3| 2| 2| 2| 2| | | 0| 9| 0| 7| 9| 9| 0| 9| 9| 9| 0| 9| 7| 7| 0| 9| 0| 0| 3| 9| 0| 9| 1| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 168 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Mediastinal, Osteosarcoma, | | | Metastatic, Uncertain Primary | | | Site | X | 1 | Renal, Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + M + + + + M + + M + M + + + + M + M + M| 37 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + M A A + + + + + + + + + + +| 42 | Lymphoma Malignant | X X X X | 4 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + A M + + + + + + + + + + +| 47 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X X | 2 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + M + + + + + + + + + + +| 43 | Lymphoma Malignant | X X | 2 | Osteosarcoma, Metastatic, Uncertain | | | Primary Site | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Sarcoma, Metastatic, Uterus | | 1 | Subcutaneous Tissue, Hemangiosarcoma | X | 1 | Subcutaneous Tissue, Lymphoma | | | Malignant | X | 1 | Subcutaneous Tissue, Sarcoma | | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 32 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| | DAY ON TEST | 3| 0| 3| 4| 2| 2| 3| 2| 2| 8| 3| 2| 6| 7| 3| 2| 3| 3| 5| 2| 3| 2| 2| 2| 2| | | 0| 9| 0| 7| 9| 9| 0| 9| 9| 9| 0| 9| 7| 7| 0| 9| 0| 0| 3| 9| 0| 9| 1| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 168 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| MUSCULOSKELETAL SYSTEM - cont | | | | | | Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Harderian | | | Gland | X | 1 | |__________________________________________________________________________|____________| Skeletal Muscle | + + | 2 | Osteosarcoma, Metastatic, Uncertain | | | Primary Site | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X | 2 | Alveolar/Bronchiolar Carcinoma | | 1 | Carcinoma, Metastatic, Harderian | | | Gland | X | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 2 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X | 1 | Osteosarcoma, Metastatic, Uncertain | | | Primary Site | X | 1 | Sarcoma, Metastatic, Skin | | 2 | Mediastinum, Osteosarcoma, | | | Metastatic, Uncertain Primary | | | Site | X | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 33 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| | DAY ON TEST | 3| 0| 3| 4| 2| 2| 3| 2| 2| 8| 3| 2| 6| 7| 3| 2| 3| 3| 5| 2| 3| 2| 2| 2| 2| | | 0| 9| 0| 7| 9| 9| 0| 9| 9| 9| 0| 9| 7| 7| 0| 9| 0| 0| 3| 9| 0| 9| 1| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 168 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + A A + + + + + + + + + + +| 46 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | | 1 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X | 4 | Carcinoma | X X | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Histiocytic Sarcoma | | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + A + + + + + + + + + + + + + + + + + + + + +| 47 | Lymphoma Malignant | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X X X X X | 6 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 34 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 _____________________________________________________________________________________________________________________ | 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 5| 7| 6| 7| DAY ON TEST | 1| 2| 0| 6| 2| 3| 2| 3| 2| 3| 0| 2| 1| 3| 6| 3| 3| 2| 3| 2| 0| 0| 3| 2| 3| | 7| 9| 3| 0| 9| 0| 9| 0| 9| 0| 8| 9| 7| 0| 1| 0| 0| 9| 0| 3| 1| 9| 0| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 504 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | A + + A + M + + + + A + + + + + M + + A + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + A + + + + + + A + + + + + + + + A + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | I + + + + + + + + + A + + + + + + + + A + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | A + + A + + + + + + A + + + + + + + + A + + + + +| Leiomyoma | X | Lymphoma Malignant | | |__________________________________________________________________________| Intestine Small, Duodenum | A + + A + + + + + + A + + + + + + + + A M + + + +| Polyp Adenomatous | | |__________________________________________________________________________| Intestine Small, Jejunum | + + + A + + + + + + A + + + + + + + + A + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | A + + A + + + + + + A + + + + + + + + A + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + A + + + + + + + + + + + + + +| Hemangiosarcoma | X | Hepatocellular Carcinoma | X X | Hepatocellular Adenoma | X X X X X X| Hepatocellular Adenoma, Multiple | X X X | Histiocytic Sarcoma | X X | Lymphoma Malignant | X X X X | |__________________________________________________________________________| Mesentery | + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Histiocytic Sarcoma | X | Lymphoma Malignant | | Sarcoma, Metastatic, Skin | | |__________________________________________________________________________| Pancreas | + + + A + + + + + + A + + + + + + + + A + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 35 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 _____________________________________________________________________________________________________________________ | 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 5| 7| 6| 7| DAY ON TEST | 1| 2| 0| 6| 2| 3| 2| 3| 2| 3| 0| 2| 1| 3| 6| 3| 3| 2| 3| 2| 0| 0| 3| 2| 3| | 7| 9| 3| 0| 9| 0| 9| 0| 9| 0| 8| 9| 7| 0| 1| 0| 0| 9| 0| 3| 1| 9| 0| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 504 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Salivary Glands | + + + + + + + + + + M + + + + + + + + + + + + + +| Lymphoma Malignant | X X | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + A + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Stomach, Glandular | + + + A + + + + + + A + + + + + + + + A + + + + +| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + A + + + + + + + + + + + + + +| Lymphoma Malignant | X | Sarcoma, Metastatic, Skin | | |__________________________________________________________________________| Adrenal Medulla | + + + M + + + + + + A + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Islets, Pancreatic | + + + A + + + + + + A + + + + + + + + A + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + M M + + + + + + + M + + + + + A + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + A + + + + +| Lymphoma Malignant | X | Pars Distalis, Adenoma | | Pars Intermedia, Adenoma | | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + A + + + + + + + + A + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | __________________________________________|__________________________________________________________________________| Page 36 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 _____________________________________________________________________________________________________________________ | 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 5| 7| 6| 7| DAY ON TEST | 1| 2| 0| 6| 2| 3| 2| 3| 2| 3| 0| 2| 1| 3| 6| 3| 3| 2| 3| 2| 0| 0| 3| 2| 3| | 7| 9| 3| 0| 9| 0| 9| 0| 9| 0| 8| 9| 7| 0| 1| 0| 0| 9| 0| 3| 1| 9| 0| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 504 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + M I + + + + + M + + M + + M + + + M I M + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + A + + + + +| Hemangioma | X | Histiocytic Sarcoma | X | Lymphoma Malignant | X | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | Polyp Stromal | X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X X X | Lymphoma Malignant | X X | |__________________________________________________________________________| Lymph Node | + + + A + + | Bronchial, Lymphoma Malignant | X | Iliac, Lymphoma Malignant | X | Mediastinal, Lymphoma Malignant | X X | Pancreatic, Lymphoma Malignant | X X | Renal, Lymphoma Malignant | X X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + M + + + + + + M + + + + + + + + I + + M + +| Lymphoma Malignant | X X X X X | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + A + + + + + + A + + + M + + + + A + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant | X X X | |__________________________________________________________________________| Spleen | + + + A + + + + + + A + + + + + + + + A + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant | X X X X X | |__________________________________________________________________________| Thymus | + + M A M M + M + M + + + + + + + + + M M + + + +| __________________________________________|__________________________________________________________________________| Page 37 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 _____________________________________________________________________________________________________________________ | 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 5| 7| 6| 7| DAY ON TEST | 1| 2| 0| 6| 2| 3| 2| 3| 2| 3| 0| 2| 1| 3| 6| 3| 3| 2| 3| 2| 0| 0| 3| 2| 3| | 7| 9| 3| 0| 9| 0| 9| 0| 9| 0| 8| 9| 7| 0| 1| 0| 0| 9| 0| 3| 1| 9| 0| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 504 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymphoma Malignant | X X | Sarcoma, Metastatic, Skin | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Hemangioma | X | Subcutaneous Tissue, Histiocytic | | Sarcoma | X | Subcutaneous Tissue, Liposarcoma | X | Subcutaneous Tissue, Myxoma | X | Subcutaneous Tissue, Sarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Meningioma Malignant | | |__________________________________________________________________________| Peripheral Nerve | + | |__________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Alveolar/Bronchiolar Carcinoma | | Carcinoma, Metastatic, Harderian | | Gland | | __________________________________________|__________________________________________________________________________| Page 38 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 _____________________________________________________________________________________________________________________ | 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 5| 7| 6| 7| DAY ON TEST | 1| 2| 0| 6| 2| 3| 2| 3| 2| 3| 0| 2| 1| 3| 6| 3| 3| 2| 3| 2| 0| 0| 3| 2| 3| | 7| 9| 3| 0| 9| 0| 9| 0| 9| 0| 8| 9| 7| 0| 1| 0| 0| 9| 0| 3| 1| 9| 0| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 504 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Hepatocellular Carcinoma, Metastatic,| | Liver | X X | Histiocytic Sarcoma | X X | Liposarcoma, Metastatic, Skin | X | Lymphoma Malignant | X | Sarcoma, Metastatic, Skin | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + A + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | | |__________________________________________________________________________| Harderian Gland | + + M M + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + A + + + + + + + + A + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant | X | |__________________________________________________________________________| Urinary Bladder | + + + A + + + + + + A + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X X X | Lymphoma Malignant | X X X X X X X X | __________________________________________|__________________________________________________________________________| Page 39 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| | DAY ON TEST | 5| 2| 2| 0| 8| 3| 7| 3| 2| 3| 3| 3| 2| 9| 2| 2| 3| 3| 2| 4| 2| 3| 2| 2| 2| | | 2| 9| 9| 1| 3| 0| 9| 0| 9| 0| 0| 0| 9| 8| 9| 9| 0| 0| 9| 5| 9| 0| 9| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 504 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | |__________________________________________________________________________|____________| Gallbladder | A + + A A + + + + + + + + A M + + + + A + + + + +| 38 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A + + + + +| 46 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A + + + + +| 46 | |__________________________________________________________________________|____________| Intestine Large, Cecum | A + + + + + + + + + + + + A + + + + + A + + + + +| 43 | Leiomyoma | | 1 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | A + + + A + + + + + + + + + + + + + + A + + + + +| 42 | Polyp Adenomatous | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | A + + A A + + + + + + + + A + + + + + A + + + + +| 42 | |__________________________________________________________________________|____________| Intestine Small, Ileum | A + + A A + + + + + + + + + + + + + + A + + + + +| 42 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemangiosarcoma | X X X | 4 | Hepatocellular Carcinoma | X | 3 | Hepatocellular Adenoma | X X X | 9 | Hepatocellular Adenoma, Multiple | X X X| 6 | Histiocytic Sarcoma | | 2 | Lymphoma Malignant | X X X | 7 | |__________________________________________________________________________|____________| Mesentery | + + + + + + + + + + + + + + + + + + + + +| 42 | Hemangiosarcoma | X | 1 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X | 1 | Sarcoma, Metastatic, Skin | X | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 40 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| | DAY ON TEST | 5| 2| 2| 0| 8| 3| 7| 3| 2| 3| 3| 3| 2| 9| 2| 2| 3| 3| 2| 4| 2| 3| 2| 2| 2| | | 2| 9| 9| 1| 3| 0| 9| 0| 9| 0| 0| 0| 9| 8| 9| 9| 0| 0| 9| 5| 9| 0| 9| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 504 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + A + + + + +| 46 | Lymphoma Malignant | X X | 3 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 | Lymphoma Malignant | | 2 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | Lymphoma Malignant | X | 2 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + A + + + + +| 46 | Lymphoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | Lymphoma Malignant | X | 2 | Sarcoma, Metastatic, Skin | X | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + A + + + + +| 47 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + A + + + + +| 46 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + M + + + + + + + + + M + M M + + A + + + M +| 40 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 41 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| | DAY ON TEST | 5| 2| 2| 0| 8| 3| 7| 3| 2| 3| 3| 3| 2| 9| 2| 2| 3| 3| 2| 4| 2| 3| 2| 2| 2| | | 2| 9| 9| 1| 3| 0| 9| 0| 9| 0| 0| 0| 9| 8| 9| 9| 0| 0| 9| 5| 9| 0| 9| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 504 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Lymphoma Malignant | | 1 | Pars Distalis, Adenoma | X X | 2 | Pars Intermedia, Adenoma | X | 1 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + A + + + M +| 46 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | M + + + M + + + + + + + M M + M + + + M + I + + +| 35 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 | Hemangioma | X | 2 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X X | 3 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 1 | Polyp Stromal | | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | Histiocytic Sarcoma | | 3 | Lymphoma Malignant | X X | 4 | |__________________________________________________________________________|____________| Lymph Node | + + + + + | 10 | Bronchial, Lymphoma Malignant | X | 2 | Iliac, Lymphoma Malignant | | 1 | Mediastinal, Lymphoma Malignant | X X | 4 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 42 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| | DAY ON TEST | 5| 2| 2| 0| 8| 3| 7| 3| 2| 3| 3| 3| 2| 9| 2| 2| 3| 3| 2| 4| 2| 3| 2| 2| 2| | | 2| 9| 9| 1| 3| 0| 9| 0| 9| 0| 0| 0| 9| 8| 9| 9| 0| 0| 9| 5| 9| 0| 9| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 504 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Pancreatic, Lymphoma Malignant | | 2 | Renal, Lymphoma Malignant | X X X | 5 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | M + + + + M + M + + + M M + + + M + + M + + + + +| 39 | Lymphoma Malignant | X X X X | 9 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + A + + + + +| 45 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X X X X | 7 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + A + + + + +| 46 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X X X X X X| 11 | |__________________________________________________________________________|____________| Thymus | + + + + + I + + + + + + + M + M M + + A M + + + +| 36 | Lymphoma Malignant | | 2 | Sarcoma, Metastatic, Skin | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Hemangioma | | 1 | Subcutaneous Tissue, Histiocytic | | | Sarcoma | | 1 | Subcutaneous Tissue, Liposarcoma | | 1 | Subcutaneous Tissue, Myxoma | | 1 | Subcutaneous Tissue, Sarcoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 43 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| | DAY ON TEST | 5| 2| 2| 0| 8| 3| 7| 3| 2| 3| 3| 3| 2| 9| 2| 2| 3| 3| 2| 4| 2| 3| 2| 2| 2| | | 2| 9| 9| 1| 3| 0| 9| 0| 9| 0| 0| 0| 9| 8| 9| 9| 0| 0| 9| 5| 9| 0| 9| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 504 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| MUSCULOSKELETAL SYSTEM - cont | | | | | | Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteosarcoma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Meningioma Malignant | X | 1 | |__________________________________________________________________________|____________| Peripheral Nerve | | 1 | |__________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X | 1 | Alveolar/Bronchiolar Carcinoma | X | 1 | Carcinoma, Metastatic, Harderian | | | Gland | X X | 2 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 2 | Histiocytic Sarcoma | | 2 | Liposarcoma, Metastatic, Skin | | 1 | Lymphoma Malignant | X X | 3 | Sarcoma, Metastatic, Skin | X | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 44 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| | DAY ON TEST | 5| 2| 2| 0| 8| 3| 7| 3| 2| 3| 3| 3| 2| 9| 2| 2| 3| 3| 2| 4| 2| 3| 2| 2| 2| | | 2| 9| 9| 1| 3| 0| 9| 0| 9| 0| 0| 0| 9| 8| 9| 9| 0| 0| 9| 5| 9| 0| 9| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 504 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Eye | + + | 2 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + +| 46 | Adenoma | | 3 | Carcinoma | X X | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | A + + + + + + + + + + + + + + + + + + A + + + + +| 46 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X X X| 4 | |__________________________________________________________________________|____________| Urinary Bladder | + + M + + + + + + + + + + + + + + + + A + + + + +| 46 | Lymphoma Malignant | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 3 | Lymphoma Malignant | X X X X X X X X| 16 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 45 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 4| 7| 6| 7| 7| 7| DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 9| 3| 9| 3| 3| 7| 3| 4| 3| 3| 3| | 1| 1| 0| 0| 1| 0| 1| 0| 1| 1| 1| 6| 0| 1| 0| 0| 0| 1| 0| 7| 1| 6| 1| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | + + A + + + + + + + + + + + M + M M M + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma, Metastatic, Liver | X | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + I +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + A + + + + + + + + + + + + + A + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X X X | Lymphoma Malignant | X | Sarcoma, Metastatic, Liver | X | |__________________________________________________________________________| Intestine Small, Ileum | + + A + + + + + + + + + + + + + A + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Hepatoblastoma | X | Hepatocellular Carcinoma | X X X | Hepatocellular Carcinoma, Multiple | X | Hepatocellular Adenoma | X X X | Hepatocellular Adenoma, Multiple | X X X X | Histiocytic Sarcoma | X | |__________________________________________________________________________| Mesentery | + + + + + | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 46 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 4| 7| 6| 7| 7| 7| DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 9| 3| 9| 3| 3| 7| 3| 4| 3| 3| 3| | 1| 1| 0| 0| 1| 0| 1| 0| 1| 1| 1| 6| 0| 1| 0| 0| 0| 1| 0| 7| 1| 6| 1| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Stomach, Forestomach | + + A + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + A + + + + + + + + + + + + + + + + + + + + + +| Sarcoma, Metastatic, Liver | X | |__________________________________________________________________________| Tooth | + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma, Metastatic, Liver | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcapsular, Adenoma | X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + M + + + + + + + + M + + + + + + + M +| |__________________________________________________________________________| Pituitary Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thyroid Gland | I + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Coagulating Gland | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 47 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 4| 7| 6| 7| 7| 7| DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 9| 3| 9| 3| 3| 7| 3| 4| 3| 3| 3| | 1| 1| 0| 0| 1| 0| 1| 0| 1| 1| 1| 6| 0| 1| 0| 0| 0| 1| 0| 7| 1| 6| 1| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma, Metastatic, Liver | X | |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X X | |__________________________________________________________________________| Lymph Node | + | Renal, Lymphoma Malignant | X | |__________________________________________________________________________| Lymph Node, Mandibular | M + M + M + M M + + + + M M + M + + + M + + + + M| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + M| Histiocytic Sarcoma | X | Lymphoma Malignant | X X X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + A + + + + + + + +| Lymphoma Malignant | X X | |__________________________________________________________________________| Thymus | + + + + + + M + + + + + + + + + M + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 48 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 4| 7| 6| 7| 7| 7| DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 9| 3| 9| 3| 3| 7| 3| 4| 3| 3| 3| | 1| 1| 0| 0| 1| 0| 1| 0| 1| 1| 1| 6| 0| 1| 0| 0| 0| 1| 0| 7| 1| 6| 1| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Chondroma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X | Alveolar/Bronchiolar Adenoma, | | Multiple | | Alveolar/Bronchiolar Carcinoma | X X X | Alveolar/Bronchiolar Carcinoma, | | Multiple | X | Hepatocellular Carcinoma, Metastatic,| | Liver | X X | Histiocytic Sarcoma | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X X X| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | __________________________________________|__________________________________________________________________________| Page 49 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________|__________________________________________________________________________ | 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 4| 7| 6| 7| 7| 7| DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 9| 3| 9| 3| 3| 7| 3| 4| 3| 3| 3| | 1| 1| 0| 0| 1| 0| 1| 0| 1| 1| 1| 6| 0| 1| 0| 0| 0| 1| 0| 7| 1| 6| 1| 1| 0| _____________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | Lymphoma Malignant | X X X | __________________________________________|__________________________________________________________________________| Page 50 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 0| 3| 2| 3| 3| 3| 3| | | 0| 1| 1| 0| 1| 1| 1| 1| 1| 1| 4| 0| 9| 0| 1| 0| 1| 0| 2| 2| 0| 0| 1| 1| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Gallbladder | + M + + + + + + + M + + A + + + + + + M M + + + +| 40 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Sarcoma, Metastatic, Liver | | 1 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + A + A + + + + + + + + + + + +| 47 | Carcinoma | X | 4 | Lymphoma Malignant | | 1 | Sarcoma, Metastatic, Liver | | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + A + A + + + + + + + + + + + +| 46 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | X | 2 | Hepatoblastoma | | 1 | Hepatocellular Carcinoma | X X X X| 7 | Hepatocellular Carcinoma, Multiple | X X X | 4 | Hepatocellular Adenoma | X X X X X X X | 10 | Hepatocellular Adenoma, Multiple | X X X X X| 9 | Histiocytic Sarcoma | | 1 | |__________________________________________________________________________|____________| Mesentery | + + + + + | 10 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 51 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 0| 3| 2| 3| 3| 3| 3| | | 0| 1| 1| 0| 1| 1| 1| 1| 1| 1| 4| 0| 9| 0| 1| 0| 1| 0| 2| 2| 0| 0| 1| 1| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Histiocytic Sarcoma | | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Sarcoma, Metastatic, Liver | | 1 | |__________________________________________________________________________|____________| Tooth | + + + + + + + + + + + + + + + + + + | 33 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Sarcoma, Metastatic, Liver | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcapsular, Adenoma | X | 2 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Parathyroid Gland | + + M + + + + + + + + + + + + + + + M + + + M + +| 44 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + M + + + + + + M + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 48 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 52 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 0| 3| 2| 3| 3| 3| 3| | | 0| 1| 1| 0| 1| 1| 1| 1| 1| 1| 4| 0| 9| 0| 1| 0| 1| 0| 2| 2| 0| 0| 1| 1| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Coagulating Gland | + | 1 | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Preputial Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemangiosarcoma | | 1 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Sarcoma, Metastatic, Liver | | 1 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | | 2 | |__________________________________________________________________________|____________| Lymph Node | | 1 | Renal, Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + M + + + M + + M M M M + + + M M M + + + M M + M| 28 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + M + + + + + + + + + + + + + + + + + + + + + +| 48 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | | 3 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant | | 2 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 53 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 0| 3| 2| 3| 3| 3| 3| | | 0| 1| 1| 0| 1| 1| 1| 1| 1| 1| 4| 0| 9| 0| 1| 0| 1| 0| 2| 2| 0| 0| 1| 1| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Thymus | + + + + + + + + + + + M M + + M M + M M + M + + M| 40 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M + M M| 1 | |__________________________________________________________________________|____________| Skin | + + + + I + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Chondroma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X X X X X| 9 | Alveolar/Bronchiolar Adenoma, | | | Multiple | X | 1 | Alveolar/Bronchiolar Carcinoma | X | 4 | Alveolar/Bronchiolar Carcinoma, | | | Multiple | | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X X X X X| 7 | Histiocytic Sarcoma | | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 54 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 0| 3| 2| 3| 3| 3| 3| | | 0| 1| 1| 0| 1| 1| 1| 1| 1| 1| 4| 0| 9| 0| 1| 0| 1| 0| 2| 2| 0| 0| 1| 1| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | X | 6 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 55 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 0| 3| 4| 3| 3| | 0| 0| 0| 1| 1| 1| 1| 1| 0| 0| 0| 0| 8| 0| 0| 1| 1| 1| 1| 0| 8| 1| 6| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 56 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | + + + + + + + + + + + + A M + + + + + + + + A + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + A + + + + + + + + + A + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + + + + + A + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + + + A + +| Mast Cell Tumor Malignant, | | Metastatic, Bone Marrow | | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + + A + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + A + +| Carcinoma | | Polyp Adenomatous | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + A + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatoblastoma | X | Hepatocellular Carcinoma | X X X X | Hepatocellular Carcinoma, Multiple | X | Hepatocellular Adenoma | X X X X X X | Hepatocellular Adenoma, Multiple | X X | Mast Cell Tumor Malignant, | | Metastatic, Bone Marrow | | Squamous Cell Carcinoma, Metastatic, | | Stomach, Forestomach | | |__________________________________________________________________________| Mesentery | + + + | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | Squamous Cell Carcinoma, Metastatic, | | __________________________________________|__________________________________________________________________________| Page 56 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 0| 3| 4| 3| 3| | 0| 0| 0| 1| 1| 1| 1| 1| 0| 0| 0| 0| 8| 0| 0| 1| 1| 1| 1| 0| 8| 1| 6| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 56 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Stomach, Forestomach | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Mast Cell Tumor Malignant, | | Metastatic, Bone Marrow | | Squamous Cell Carcinoma | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + A + +| Mast Cell Tumor Malignant, | | Metastatic, Bone Marrow | | Squamous Cell Carcinoma, Metastatic, | | Stomach, Forestomach | | |__________________________________________________________________________| Tooth | + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Mast Cell Tumor Malignant, | | Metastatic, Bone Marrow | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma, Metastatic, | | Stomach, Forestomach | | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + M + + M + + + + + + A M + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 57 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 0| 3| 4| 3| 3| | 0| 0| 0| 1| 1| 1| 1| 1| 0| 0| 0| 0| 8| 0| 0| 1| 1| 1| 1| 0| 8| 1| 6| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 56 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + A + + + + + + + + + + + +| C-Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Peritoneum | | Mast Cell Tumor Malignant, | | Metastatic, Bone Marrow | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma, Metastatic, | | Stomach, Forestomach | | |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Adenoma | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Mast Cell Tumor Malignant | | |__________________________________________________________________________| Lymph Node | | Mediastinal, Mast Cell Tumor | | Malignant, Metastatic, Bone | | Marrow | | __________________________________________|__________________________________________________________________________| Page 58 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 0| 3| 4| 3| 3| | 0| 0| 0| 1| 1| 1| 1| 1| 0| 0| 0| 0| 8| 0| 0| 1| 1| 1| 1| 0| 8| 1| 6| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 56 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | |__________________________________________________________________________| Lymph Node, Mandibular | + M M + + + M + M + M M M + M + M + M M M + M + +| Mast Cell Tumor Malignant, | | Metastatic, Bone Marrow | | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + + + + + M| Lymphoma Malignant | X | Squamous Cell Carcinoma, Metastatic, | | Stomach, Forestomach | | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | Mast Cell Tumor Malignant, | | Metastatic, Bone Marrow | | Squamous Cell Carcinoma, Metastatic, | | Stomach, Forestomach | | |__________________________________________________________________________| Thymus | + M + + + + M M + + + + + + I + + + + M + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M + M M M M| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Melanoma | | Malignant | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Mast Cell Tumor Malignant, | | Metastatic, Bone Marrow | | |__________________________________________________________________________| Skeletal Muscle | | Mast Cell Tumor Malignant, | | Metastatic, Bone Marrow | | __________________________________________|__________________________________________________________________________| Page 59 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 0| 3| 4| 3| 3| | 0| 0| 0| 1| 1| 1| 1| 1| 0| 0| 0| 0| 8| 0| 0| 1| 1| 1| 1| 0| 8| 1| 6| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 56 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | Squamous Cell Carcinoma, Metastatic, | | Stomach, Forestomach | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X | Alveolar/Bronchiolar Carcinoma | X X | Hepatocellular Carcinoma, Metastatic,| | Liver | | Mediastinum, Mast Cell Tumor | | Malignant, Metastatic, Bone | | Marrow | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Mast Cell Tumor Malignant, | | Metastatic, Bone Marrow | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X X X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma, Metastatic, | | Stomach, Forestomach | | __________________________________________|__________________________________________________________________________| Page 60 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 0| 3| 4| 3| 3| | 0| 0| 0| 1| 1| 1| 1| 1| 0| 0| 0| 0| 8| 0| 0| 1| 1| 1| 1| 0| 8| 1| 6| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 56 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| URINARY SYSTEM - cont | | | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + A + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________|__________________________________________________________________________| Page 61 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 7| 0| 7| 7| 4| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 5| 7| | DAY ON TEST | 3| 1| 3| 3| 5| 3| 3| 8| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 1| 0| 3| | | 1| 1| 1| 1| 5| 0| 0| 8| 1| 0| 8| 1| 1| 0| 0| 0| 0| 1| 0| 0| 7| 0| 1| 8| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 56 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Gallbladder | + + + + + + M + I + + + + M + M + I + I A M + A +| 38 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +| 47 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A + + + +| 47 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + + +| 47 | Mast Cell Tumor Malignant, | | | Metastatic, Bone Marrow | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + + +| 47 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + A +| 47 | Carcinoma | X | 1 | Polyp Adenomatous | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A + + + +| 47 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatoblastoma | | 1 | Hepatocellular Carcinoma | X X X X X X X X | 12 | Hepatocellular Carcinoma, Multiple | | 1 | Hepatocellular Adenoma | X X X X X X | 12 | Hepatocellular Adenoma, Multiple | X | 3 | Mast Cell Tumor Malignant, | | | Metastatic, Bone Marrow | X | 1 | Squamous Cell Carcinoma, Metastatic, | | | Stomach, Forestomach | X | 1 | |__________________________________________________________________________|____________| Mesentery | + | 4 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 62 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 7| 0| 7| 7| 4| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 5| 7| | DAY ON TEST | 3| 1| 3| 3| 5| 3| 3| 8| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 1| 0| 3| | | 1| 1| 1| 1| 5| 0| 0| 8| 1| 0| 8| 1| 1| 0| 0| 0| 0| 1| 0| 0| 7| 0| 1| 8| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 56 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 1 | Squamous Cell Carcinoma, Metastatic, | | | Stomach, Forestomach | X | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mast Cell Tumor Malignant, | | | Metastatic, Bone Marrow | X | 1 | Squamous Cell Carcinoma | X | 1 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Mast Cell Tumor Malignant, | | | Metastatic, Bone Marrow | X | 1 | Squamous Cell Carcinoma, Metastatic, | | | Stomach, Forestomach | X | 1 | |__________________________________________________________________________|____________| Tooth | + + + + + + + + + + + +| 27 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + | 1 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mast Cell Tumor Malignant, | | | Metastatic, Bone Marrow | X | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 63 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 7| 0| 7| 7| 4| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 5| 7| | DAY ON TEST | 3| 1| 3| 3| 5| 3| 3| 8| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 1| 0| 3| | | 1| 1| 1| 1| 5| 0| 0| 8| 1| 0| 8| 1| 1| 0| 0| 0| 0| 1| 0| 0| 7| 0| 1| 8| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 56 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Carcinoma, Metastatic, | | | Stomach, Forestomach | X | 1 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + M + + + + + + M + + + + + + M + + + + M| 42 | |__________________________________________________________________________|____________| Pituitary Gland | I + + + + + + + + + + + + + + I + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | C-Cell, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Peritoneum | + | 1 | Mast Cell Tumor Malignant, | | | Metastatic, Bone Marrow | X | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + I + + + + + + +| 49 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Carcinoma, Metastatic, | | | Stomach, Forestomach | X | 1 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 64 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 7| 0| 7| 7| 4| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 5| 7| | DAY ON TEST | 3| 1| 3| 3| 5| 3| 3| 8| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 1| 0| 3| | | 1| 1| 1| 1| 5| 0| 0| 8| 1| 0| 8| 1| 1| 0| 0| 0| 0| 1| 0| 0| 7| 0| 1| 8| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 56 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Interstitial Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mast Cell Tumor Malignant | X | 1 | |__________________________________________________________________________|____________| Lymph Node | + | 1 | Mediastinal, Mast Cell Tumor | | | Malignant, Metastatic, Bone | | | Marrow | X | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + M M + + + + M + + + + + + + + + + M M M M + M| 29 | Mast Cell Tumor Malignant, | | | Metastatic, Bone Marrow | X | 1 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + A + + + +| 46 | Lymphoma Malignant | | 1 | Squamous Cell Carcinoma, Metastatic, | | | Stomach, Forestomach | X | 1 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 1 | Mast Cell Tumor Malignant, | | | Metastatic, Bone Marrow | X | 1 | Squamous Cell Carcinoma, Metastatic, | | | Stomach, Forestomach | X | 1 | |__________________________________________________________________________|____________| Thymus | + + + + + + + M + M + + + + + + M + + + + I M + M| 39 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 65 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 7| 0| 7| 7| 4| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 5| 7| | DAY ON TEST | 3| 1| 3| 3| 5| 3| 3| 8| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 1| 0| 3| | | 1| 1| 1| 1| 5| 0| 0| 8| 1| 0| 8| 1| 1| 0| 0| 0| 0| 1| 0| 0| 7| 0| 1| 8| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 56 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Mammary Gland | M M M M M M + M M M M M M M M M M M M M M M M M M| 2 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Melanoma | | | Malignant | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mast Cell Tumor Malignant, | | | Metastatic, Bone Marrow | X | 1 | |__________________________________________________________________________|____________| Skeletal Muscle | + + | 2 | Mast Cell Tumor Malignant, | | | Metastatic, Bone Marrow | X | 1 | Squamous Cell Carcinoma, Metastatic, | | | Stomach, Forestomach | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | | 3 | Alveolar/Bronchiolar Carcinoma | X | 3 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X X X | 3 | Mediastinum, Mast Cell Tumor | | | Malignant, Metastatic, Bone | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 66 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 7| 0| 7| 7| 4| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 5| 7| | DAY ON TEST | 3| 1| 3| 3| 5| 3| 3| 8| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 1| 0| 3| | | 1| 1| 1| 1| 5| 0| 0| 8| 1| 0| 8| 1| 1| 0| 0| 0| 0| 1| 0| 0| 7| 0| 1| 8| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 56 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | Marrow | X | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mast Cell Tumor Malignant, | | | Metastatic, Bone Marrow | X | 1 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | | 1 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + M + + + + + + + + + + + + + +| 48 | Adenoma | X X X X | 9 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Carcinoma, Metastatic, | | | Stomach, Forestomach | X | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 67 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| DAY ON TEST | 3| 3| 3| 4| 3| 3| 3| 5| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 1| 3| 3| | 1| 1| 1| 8| 1| 1| 1| 3| 0| 1| 1| 0| 0| 0| 0| 0| 1| 1| 2| 1| 1| 1| 1| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 168 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + A + M + + + M| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + I + + + + + + + + + + A + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + A + + + + + + + + + + A + + + + + +| Carcinoma | | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + A + + + + + +| Carcinoma | X | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + A + A + + + + + + + + A + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + A + A + + + + + + + + A + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Hepatocellular Carcinoma | X X X X X X X| Hepatocellular Carcinoma, Multiple | X X X | Hepatocellular Adenoma | X X X X X | Hepatocellular Adenoma, Multiple | X X | |__________________________________________________________________________| Mesentery | + + + + + + + + + + | Sarcoma | | |__________________________________________________________________________| Pancreas | + + + + + + + + + A + + + + + + + + + + + + + + +| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 68 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| DAY ON TEST | 3| 3| 3| 4| 3| 3| 3| 5| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 1| 3| 3| | 1| 1| 1| 8| 1| 1| 1| 3| 0| 1| 1| 0| 0| 0| 0| 0| 1| 1| 2| 1| 1| 1| 1| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 168 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Stomach, Glandular | + + + + + + + + + + + + + + + + + + A + + + + + +| |__________________________________________________________________________| Tooth | + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma, Metastatic,| | Liver | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + + + + + +| Adenoma | | |__________________________________________________________________________| Parathyroid Gland | + + M + + + + M + + M + + + + + M M + + + M M + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 69 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| DAY ON TEST | 3| 3| 3| 4| 3| 3| 3| 5| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 1| 3| 3| | 1| 1| 1| 8| 1| 1| 1| 3| 0| 1| 1| 0| 0| 0| 0| 0| 1| 1| 2| 1| 1| 1| 1| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 168 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Sarcoma | X | |__________________________________________________________________________| Lymph Node | + | Renal, Lymphoma Malignant | X | |__________________________________________________________________________| Lymph Node, Mandibular | M M + M + + + + + + + + + + + M M M M + + + + M +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + A M + + + + + + + A + + + + + +| Lymphoma Malignant | X | Sarcoma, Metastatic, Mesentery | | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant | X | |__________________________________________________________________________| Thymus | + + + + I + + + + M + + + + + + + M + M + M + + M| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 70 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| DAY ON TEST | 3| 3| 3| 4| 3| 3| 3| 5| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 1| 3| 3| | 1| 1| 1| 8| 1| 1| 1| 3| 0| 1| 1| 0| 0| 0| 0| 0| 1| 1| 2| 1| 1| 1| 1| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 168 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X X X X X | Alveolar/Bronchiolar Carcinoma | X X X | Hepatocellular Carcinoma, Metastatic,| | Liver | X X X X X X| |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + A + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| Adenoma | X X X | Carcinoma | | Bilateral, Adenoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + A + + + + + +| Hemangiosarcoma | | Transitional Epithelium, Papilloma | | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X | __________________________________________|__________________________________________________________________________| Page 71 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| | DAY ON TEST | 6| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 8| 3| 9| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 2| | | 5| 1| 0| 1| 0| 0| 0| 1| 0| 0| 1| 0| 0| 7| 0| 3| 1| 1| 0| 1| 0| 0| 1| 0| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 168 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Gallbladder | A + + + + M + M + + M A + A + + + + + + + + I A +| 39 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + A + A + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Large, Rectum | A + + + + + + + + + + + + A + + + + + + + + + + +| 46 | |__________________________________________________________________________|____________| Intestine Large, Cecum | A + + + + + + + + + + + + A + + + + + + + + + + +| 46 | Carcinoma | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | A + + + + + + + + + + A + A + + + + + + + + + A +| 44 | Carcinoma | | 1 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | A + + + + + + + + + + A + A + + + + + + + + + + +| 44 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | A + + + + + + + + + + A + A + + + + + M + + + + +| 43 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | X X X | 4 | Hepatocellular Carcinoma | X X X X| 11 | Hepatocellular Carcinoma, Multiple | X | 4 | Hepatocellular Adenoma | X X X X X | 10 | Hepatocellular Adenoma, Multiple | X X X | 5 | |__________________________________________________________________________|____________| Mesentery | + + + + + + + + + + | 20 | Sarcoma | X | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 72 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| | DAY ON TEST | 6| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 8| 3| 9| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 2| | | 5| 1| 0| 1| 0| 0| 0| 1| 0| 0| 1| 0| 0| 7| 0| 3| 1| 1| 0| 1| 0| 0| 1| 0| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 168 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Papilloma | X X | 2 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + A + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Tooth | + + + + + + + + + + + + + + + | 30 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X| 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pheochromocytoma Benign | X | 1 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | X X | 2 | |__________________________________________________________________________|____________| Parathyroid Gland | + M M + + M + + M + I + + + + + + + + M + + + + +| 37 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 73 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| | DAY ON TEST | 6| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 8| 3| 9| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 2| | | 5| 1| 0| 1| 0| 0| 0| 1| 0| 0| 1| 0| 0| 7| 0| 3| 1| 1| 0| 1| 0| 0| 1| 0| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 168 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 | Hemangiosarcoma | X | 2 | Sarcoma | | 1 | |__________________________________________________________________________|____________| Lymph Node | | 1 | Renal, Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | M M M M M + + M + + M M M + + M + + + + + + + M M| 30 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + A + A + + + + + + + + + + +| 45 | Lymphoma Malignant | | 1 | Sarcoma, Metastatic, Mesentery | X | 1 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 | Hemangiosarcoma | X | 1 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + M + + M + + + + + + + M + + M + M| 39 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 74 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| | DAY ON TEST | 6| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 8| 3| 9| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 2| | | 5| 1| 0| 1| 0| 0| 0| 1| 0| 0| 1| 0| 0| 7| 0| 3| 1| 1| 0| 1| 0| 0| 1| 0| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 168 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Keratoacanthoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X | 8 | Alveolar/Bronchiolar Carcinoma | X X | 5 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X X X X| 10 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + | 2 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | X | 4 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 75 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| | DAY ON TEST | 6| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 8| 3| 9| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 2| | | 5| 1| 0| 1| 0| 0| 0| 1| 0| 0| 1| 0| 0| 7| 0| 3| 1| 1| 0| 1| 0| 0| 1| 0| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 168 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | | | | Carcinoma | X | 1 | Bilateral, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemangiosarcoma | X | 1 | Transitional Epithelium, Papilloma | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 76 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 _____________________________________________________________________________________________________________________ | 6| 7| 7| 6| 6| 7| 0| 6| 6| 6| 7| 4| 6| 7| 5| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| DAY ON TEST | 7| 3| 3| 2| 5| 3| 1| 4| 5| 1| 3| 8| 2| 3| 7| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| | 6| 1| 0| 1| 7| 1| 7| 6| 8| 7| 0| 3| 6| 0| 6| 1| 0| 1| 1| 0| 9| 0| 0| 1| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 504 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | A + M A A + A A A A + + M + + + + + + + A + I + +| |__________________________________________________________________________| Intestine Large, Colon | A + + + A + A + A A + + + + + + + + + + A + + + +| |__________________________________________________________________________| Intestine Large, Rectum | A + + + + + + + A + + + A + + + + + + + A + + + +| |__________________________________________________________________________| Intestine Large, Cecum | A + + A A + A + A A + A + + + + + + + + A + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | A + + A A + A + A A + A + + + + + + + + A + + + +| Polyp Adenomatous | X | |__________________________________________________________________________| Intestine Small, Jejunum | A + + A A + + + A A + A A + + + + + + + A + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Intestine Small, Ileum | A + + A A + A + A A + A A + + + + + + + A + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X X X X X X| Hepatocellular Carcinoma | X X X X X | Hepatocellular Carcinoma, Multiple | X | Hepatocellular Adenoma | X X X X | Hepatocellular Adenoma, Multiple | X X X X X | Histiocytic Sarcoma | | |__________________________________________________________________________| Mesentery | + + + + + | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Salivary Glands | I + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + A A + + + + + + A + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 77 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 _____________________________________________________________________________________________________________________ | 6| 7| 7| 6| 6| 7| 0| 6| 6| 6| 7| 4| 6| 7| 5| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| DAY ON TEST | 7| 3| 3| 2| 5| 3| 1| 4| 5| 1| 3| 8| 2| 3| 7| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| | 6| 1| 0| 1| 7| 1| 7| 6| 8| 7| 0| 3| 6| 0| 6| 1| 0| 1| 1| 0| 9| 0| 0| 1| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 504 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Tooth | + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + M M M + + M + + + + I + + + + + + I + +| |__________________________________________________________________________| Pituitary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| Pars Intermedia, Adenoma | | |__________________________________________________________________________| Thyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 78 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 _____________________________________________________________________________________________________________________ | 6| 7| 7| 6| 6| 7| 0| 6| 6| 6| 7| 4| 6| 7| 5| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| DAY ON TEST | 7| 3| 3| 2| 5| 3| 1| 4| 5| 1| 3| 8| 2| 3| 7| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| | 6| 1| 0| 1| 7| 1| 7| 6| 8| 7| 0| 3| 6| 0| 6| 1| 0| 1| 1| 0| 9| 0| 0| 1| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 504 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | Seminal Vesicle | + + + + + + + + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X| Histiocytic Sarcoma | X | |__________________________________________________________________________| Lymph Node | | Mediastinal, Lymphoma Malignant | | |__________________________________________________________________________| Lymph Node, Mandibular | + M + + M + + M M + + + + + M + M + M M M M + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | A + + A A + A + A + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant | | |__________________________________________________________________________| Spleen | + + + + A + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X X| Histiocytic Sarcoma | | Lymphoma Malignant | | |__________________________________________________________________________| Thymus | M + + + + + + M M M + + + + + + M + + + M + M M +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibrous | | Histiocytoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 79 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 _____________________________________________________________________________________________________________________ | 6| 7| 7| 6| 6| 7| 0| 6| 6| 6| 7| 4| 6| 7| 5| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| DAY ON TEST | 7| 3| 3| 2| 5| 3| 1| 4| 5| 1| 3| 8| 2| 3| 7| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| | 6| 1| 0| 1| 7| 1| 7| 6| 8| 7| 0| 3| 6| 0| 6| 1| 0| 1| 1| 0| 9| 0| 0| 1| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 504 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | | Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Harderian | | Gland | | |__________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X | Alveolar/Bronchiolar Carcinoma | X X | Hepatocellular Carcinoma, Metastatic,| | Liver | X X | |__________________________________________________________________________| Nose | + + + + + + A + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pleura | | Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + M + + + + + + + +| Adenoma | X X X X X | __________________________________________|__________________________________________________________________________| Page 80 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 _____________________________________________________________________________________________________________________ | 6| 7| 7| 6| 6| 7| 0| 6| 6| 6| 7| 4| 6| 7| 5| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| DAY ON TEST | 7| 3| 3| 2| 5| 3| 1| 4| 5| 1| 3| 8| 2| 3| 7| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| | 6| 1| 0| 1| 7| 1| 7| 6| 8| 7| 0| 3| 6| 0| 6| 1| 0| 1| 1| 0| 9| 0| 0| 1| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 504 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Carcinoma | | |__________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + A + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant | | |__________________________________________________________________________| Urinary Bladder | + + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant | | __________________________________________|__________________________________________________________________________| Page 81 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 4| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| | DAY ON TEST | 9| 3| 6| 2| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 3| 3| 3| 3| 3| 8| | | 2| 0| 8| 1| 0| 1| 8| 1| 0| 0| 1| 1| 1| 1| 1| 5| 0| 1| 0| 0| 1| 0| 0| 0| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 504 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Gallbladder | A M M + + M + + + + + + + + + A + + + + + + + + +| 34 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + A + + A + + + + + + + + +| 42 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + A + + A + + + + + + + + +| 44 | |__________________________________________________________________________|____________| Intestine Large, Cecum | A + + + + + + + + + + + A + + A + + + + + + + + +| 39 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + A + + A + + + + + + + + +| 40 | Polyp Adenomatous | | 1 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | A + A + + + + + + + + + A + + A + + + + + + + + +| 38 | Lymphoma Malignant | X X | 2 | |__________________________________________________________________________|____________| Intestine Small, Ileum | A + + + + + + + + + + + A + + A + + + + + + + + +| 38 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | X X X | 9 | Hepatocellular Carcinoma | X X X X X X| 11 | Hepatocellular Carcinoma, Multiple | X | 2 | Hepatocellular Adenoma | X X X X X X | 10 | Hepatocellular Adenoma, Multiple | X X X X X | 10 | Histiocytic Sarcoma | X X | 2 | |__________________________________________________________________________|____________| Mesentery | + + + + + | 10 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 82 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 4| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| | DAY ON TEST | 9| 3| 6| 2| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 3| 3| 3| 3| 3| 8| | | 2| 0| 8| 1| 0| 1| 8| 1| 0| 0| 1| 1| 1| 1| 1| 5| 0| 1| 0| 0| 1| 0| 0| 0| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 504 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + A + + + + + + + + +| 46 | |__________________________________________________________________________|____________| Tooth | + + + + + + + + + + + + + + + | 23 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | | 1 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + M + + + + + + + + + M + M M + + + + + +| 40 | |__________________________________________________________________________|____________| Pituitary Gland | + + + I + + + + + + + + + + + + + + + + + + + + +| 48 | Pars Intermedia, Adenoma | X | 1 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Follicular Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 83 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 4| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| | DAY ON TEST | 9| 3| 6| 2| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 3| 3| 3| 3| 3| 8| | | 2| 0| 8| 1| 0| 1| 8| 1| 0| 0| 1| 1| 1| 1| 1| 5| 0| 1| 0| 0| 1| 0| 0| 0| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 504 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | | 1 | Histiocytic Sarcoma | X | 2 | |__________________________________________________________________________|____________| Lymph Node | + | 1 | Mediastinal, Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + M + M + M M + + M M + M + + + + + M M M + + +| 30 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | A + + M + + + + + + + + A + + A + + + + + + + + +| 41 | Hemangiosarcoma | X | 1 | Lymphoma Malignant | X X X | 3 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemangiosarcoma | | 2 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Thymus | + M + M + + M + + + + + + + + M + M + M + M M + M| 33 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 84 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 4| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| | DAY ON TEST | 9| 3| 6| 2| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 3| 3| 3| 3| 3| 8| | | 2| 0| 8| 1| 0| 1| 8| 1| 0| 0| 1| 1| 1| 1| 1| 5| 0| 1| 0| 0| 1| 0| 0| 0| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 504 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Fibrous | | | Histiocytoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skeletal Muscle | + | 1 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Harderian | | | Gland | X| 1 | |__________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X | 5 | Alveolar/Bronchiolar Carcinoma | X X | 4 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X X X | 5 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + A + + + + + + + + +| 47 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 85 NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ELMIRON Date: 04/25/01 Route: GAVAGE Time: 08:21:45 __________________________________________________________________________________________________________________________________ | 4| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| | DAY ON TEST | 9| 3| 6| 2| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 3| 3| 3| 3| 3| 8| | | 2| 0| 8| 1| 0| 1| 8| 1| 0| 0| 1| 1| 1| 1| 1| 5| 0| 1| 0| 0| 1| 0| 0| 0| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 504 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | Pleura | + | 1 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | X | 1 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | +| 1 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Adenoma | X | 6 | Carcinoma | X X| 2 | |__________________________________________________________________________|____________| Zymbal's Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X X | 3 | Lymphoma Malignant | X X X X | 4 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 86 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------