TDMS Study 88122-07 Pathology Tables
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
final#1/Mice
Facility: Battelle Columbus Laboratory
Chemical CAS #: 37319-17-8
Lock Date: 04/14/00
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to days on test
Page 1
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
_____________________________________________________________________________________________________________________
| 1| 4| 4| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 1| 5| 3| 8| 3| 4| 6| 6| 8| 0| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 3| 1| 6| 6| 3| 6| 7| 1| 7| 5| 3| 7| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 3| 3| 0| 1| 4| 5| 2| 2| 1| 0| 3| 3| 4| 0| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2|
| 8| 7| 6| 2| 0| 0| 9| 6| 3| 2| 0| 5| 2| 1| 4| 7| 8| 9| 0| 6| 8| 0| 3| 7| 8|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | A + + A A A + + A A + M A + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + A + + A + A A + + A + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + A + A A + + A + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | A + + A A A A + A A I + A + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | A + + A A A A + A A + + A + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | A + + A A A A + A + + + A + + + + + + + + + + + +|
Carcinoma | |
|__________________________________________________________________________|
Intestine Small, Ileum | A + + A A A A + A A + + A + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hepatocellular Carcinoma | X X |
Hepatocellular Adenoma | X X |
Hepatocellular Adenoma, Multiple | |
Sarcoma, Metastatic, Skin | X |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + |
Sarcoma, Metastatic, Skin | X |
Sarcoma, Metastatic, Uterus | X |
|__________________________________________________________________________|
Pancreas | A + + A + + A + + + + + A + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + M + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | A + + A + + + + + + + + A + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | A + + A + + A + + + + + A + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
_____________________________________________________________________________________________________________________
| 1| 4| 4| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 1| 5| 3| 8| 3| 4| 6| 6| 8| 0| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 3| 1| 6| 6| 3| 6| 7| 1| 7| 5| 3| 7| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 3| 3| 0| 1| 4| 5| 2| 2| 1| 0| 3| 3| 4| 0| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2|
| 8| 7| 6| 2| 0| 0| 9| 6| 3| 2| 0| 5| 2| 1| 4| 7| 8| 9| 0| 6| 8| 0| 3| 7| 8|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + A + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + A + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | A + + A + + A + + + + + A + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | M + + M + + + M + M I + M + + + M + + + + M + M +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | |
|__________________________________________________________________________|
Thyroid Gland | A + + A + + + + + A + + A + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | M + M M + + + M + + + + + + + + + + + M + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + M + M + + + + + + + + + + + + + +|
Cystadenoma | |
|__________________________________________________________________________|
Uterus | A + + + + + + + + + + + A + + + + + + + + + + + +|
Polyp Stromal | |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
_____________________________________________________________________________________________________________________
| 1| 4| 4| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 1| 5| 3| 8| 3| 4| 6| 6| 8| 0| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 3| 1| 6| 6| 3| 6| 7| 1| 7| 5| 3| 7| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 3| 3| 0| 1| 4| 5| 2| 2| 1| 0| 3| 3| 4| 0| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2|
| 8| 7| 6| 2| 0| 0| 9| 6| 3| 2| 0| 5| 2| 1| 4| 7| 8| 9| 0| 6| 8| 0| 3| 7| 8|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
|__________________________________________________________________________|
Lymph Node | + + + + |
Mediastinal, Sarcoma, Metastatic, | |
Skin | X |
Pancreatic, Sarcoma, Metastatic, Skin| X |
|__________________________________________________________________________|
Lymph Node, Mandibular | M + + + M M + + + M M + + + M + M M + + + M + M +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + A A + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | A + + A + + + + A + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + + + + + M + + + + M + A M + + + + + + M + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + A + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Adenoma | X |
Subcutaneous Tissue, Sarcoma | X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteosarcoma | X |
|__________________________________________________________________________|
Skeletal Muscle | + + |
Sarcoma, Metastatic, Uterus | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Oligodendroglioma Benign | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
_____________________________________________________________________________________________________________________
| 1| 4| 4| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 1| 5| 3| 8| 3| 4| 6| 6| 8| 0| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 3| 1| 6| 6| 3| 6| 7| 1| 7| 5| 3| 7| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 3| 3| 0| 1| 4| 5| 2| 2| 1| 0| 3| 3| 4| 0| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2|
| 8| 7| 6| 2| 0| 0| 9| 6| 3| 2| 0| 5| 2| 1| 4| 7| 8| 9| 0| 6| 8| 0| 3| 7| 8|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Carcinoma | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | A + + + + A + + + A + + A + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Bilateral, Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | A + + A + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Urinary Bladder | A + + A + M A + A A + + A + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X |
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 3| 3| 3| 4| 4| 4| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| L |
| 1| 2| 3| 3| 5| 9| 3| 5| 1| 4| 5| 7| 9| 1| 2| 4| 5| 4| 6| 9| 1| 4| 6| 7| 8| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + I + + + + + + + + + + + + + M + I +| 39 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 41 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + I + + + + + + + + + + + + +| 41 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 43 |
Carcinoma | X | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 42 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X | 1 |
Hepatocellular Carcinoma | X | 3 |
Hepatocellular Adenoma | X X X X | 6 |
Hepatocellular Adenoma, Multiple | X | 1 |
Sarcoma, Metastatic, Skin | | 1 |
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + + + + + + +| 30 |
Sarcoma, Metastatic, Skin | | 1 |
Sarcoma, Metastatic, Uterus | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 6
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 3| 3| 3| 4| 4| 4| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| L |
| 1| 2| 3| 3| 5| 9| 3| 5| 1| 4| 5| 7| 9| 1| 2| 4| 5| 4| 6| 9| 1| 4| 6| 7| 8| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | | 2 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M M + + M + + + + + + + + + + + + + + I| 37 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 48 |
Pars Distalis, Adenoma | X X | 2 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + M + M + M + + + + M + M + + + + I + + + + +| 39 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 3| 3| 3| 4| 4| 4| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| L |
| 1| 2| 3| 3| 5| 9| 3| 5| 1| 4| 5| 7| 9| 1| 2| 4| 5| 4| 6| 9| 1| 4| 6| 7| 8| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
Ovary | + + + + + + + + + + + + + + + + + + + + + + I + +| 47 |
Cystadenoma | X | 1 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Polyp Stromal | X X X | 3 |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node | + + | 6 |
Mediastinal, Sarcoma, Metastatic, | | |
Skin | | 1 |
Pancreatic, Sarcoma, Metastatic, Skin| | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + M M + + + + + + + + + + + M M M + M + + + +| 33 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + M + + M + + + + +| 43 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basal Cell Adenoma | | 1 |
Subcutaneous Tissue, Sarcoma | X | 3 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 3| 3| 3| 4| 4| 4| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| L |
| 1| 2| 3| 3| 5| 9| 3| 5| 1| 4| 5| 7| 9| 1| 2| 4| 5| 4| 6| 9| 1| 4| 6| 7| 8| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteosarcoma | | 1 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
Sarcoma, Metastatic, Uterus | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Oligodendroglioma Benign | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X | 2 |
Alveolar/Bronchiolar Carcinoma | X | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + M + +| 48 |
Adenoma | X X | 3 |
Bilateral, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 3| 3| 3| 4| 4| 4| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| L |
| 1| 2| 3| 3| 5| 9| 3| 5| 1| 4| 5| 7| 9| 1| 2| 4| 5| 4| 6| 9| 1| 4| 6| 7| 8| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 43 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X X X X | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
_____________________________________________________________________________________________________________________
| 0| 2| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 8| 8| 4| 5| 4| 8| 8| 0| 0| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 8| 1| 5| 1| 5| 2| 1| 1| 3| 3| 1| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
56 MG/KG | 8| 9| 8| 8| 8| 9| 6| 7| 5| 9| 9| 7| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 8|
| 3| 0| 1| 9| 0| 7| 7| 0| 5| 9| 6| 2| 2| 3| 4| 9| 1| 3| 4| 6| 8| 9| 1| 9| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + A A A + A + + + M A A + + + + + + + + M M + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + A A A + A + + + + + A + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + A A + + A + + + + + A + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + A A A + A + + + + A A + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + A A A + A + + + + + A + + + + + + + + + + + + +|
Polyp Adenomatous | X |
|__________________________________________________________________________|
Intestine Small, Jejunum | + A A A + A + + + + + A + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + A A A + A + + + + + A + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + A + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hepatocellular Carcinoma | X X |
Hepatocellular Adenoma | X |
Hepatocellular Adenoma, Multiple | X|
Histiocytic Sarcoma | X X |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Sarcoma | X |
Sarcoma, Metastatic, Skin | X |
|__________________________________________________________________________|
Pancreas | + A A + + A + + + + + A + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + M + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + A + + + + + + + + A + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + A A + + A + + + + + A + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 11
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
_____________________________________________________________________________________________________________________
| 0| 2| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 8| 8| 4| 5| 4| 8| 8| 0| 0| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 8| 1| 5| 1| 5| 2| 1| 1| 3| 3| 1| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
56 MG/KG | 8| 9| 8| 8| 8| 9| 6| 7| 5| 9| 9| 7| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 8|
| 3| 0| 1| 9| 0| 7| 7| 0| 5| 9| 6| 2| 2| 3| 4| 9| 1| 3| 4| 6| 8| 9| 1| 9| 5|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Pericardium, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | X |
Pericardium, Sarcoma | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + A + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Sarcoma, Metastatic, Skin | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + A + + + + + + + + + + + + +|
Pheochromocytoma Benign | |
|__________________________________________________________________________|
Islets, Pancreatic | + A A + + A + + + + + A + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | M M + + + + + + M + A M + M + + + + M + M + M + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + M + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X |
|__________________________________________________________________________|
Thyroid Gland | + A + + + + + + + + + M + + + + + + + + M + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | M + + + + + + + + + + M + I + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + A + + + + + + + + + + + + + I + + + + +|
Cystadenoma | X |
Histiocytic Sarcoma | X |
Luteoma | X |
__________________________________________|__________________________________________________________________________|
Page 12
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
_____________________________________________________________________________________________________________________
| 0| 2| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 8| 8| 4| 5| 4| 8| 8| 0| 0| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 8| 1| 5| 1| 5| 2| 1| 1| 3| 3| 1| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
56 MG/KG | 8| 9| 8| 8| 8| 9| 6| 7| 5| 9| 9| 7| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 8|
| 3| 0| 1| 9| 0| 7| 7| 0| 5| 9| 6| 2| 2| 3| 4| 9| 1| 3| 4| 6| 8| 9| 1| 9| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Sarcoma, Metastatic, Mesentery | X |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + A + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X |
Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + A + + + + + + + + + A + + + + + + + + + + + + +|
Hemangiosarcoma | |
Histiocytic Sarcoma | X |
|__________________________________________________________________________|
Lymph Node | + + + + + + |
Bronchial, Histiocytic Sarcoma | X X |
Lumbar, Histiocytic Sarcoma | X |
Mediastinal, Histiocytic Sarcoma | X |
Renal, Sarcoma, Metastatic, Skin | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + A + + + + + + M + + M M + + M M + + + + + + + M|
Histiocytic Sarcoma | X |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + A A M + A + + + + + A + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Sarcoma, Metastatic, Mesentery | X |
|__________________________________________________________________________|
Spleen | + + + + + A + + + + + A + + + + + + + + + + + + +|
Hemangiosarcoma | |
Histiocytic Sarcoma | |
|__________________________________________________________________________|
Thymus | + + + + + + + M + + + M M M + + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 13
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
_____________________________________________________________________________________________________________________
| 0| 2| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 8| 8| 4| 5| 4| 8| 8| 0| 0| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 8| 1| 5| 1| 5| 2| 1| 1| 3| 3| 1| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
56 MG/KG | 8| 9| 8| 8| 8| 9| 6| 7| 5| 9| 9| 7| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 8|
| 3| 0| 1| 9| 0| 7| 7| 0| 5| 9| 6| 2| 2| 3| 4| 9| 1| 3| 4| 6| 8| 9| 1| 9| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Histiocytic | |
Sarcoma | X |
Subcutaneous Tissue, Sarcoma | X X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + M + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X |
Sarcoma | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma | X |
Histiocytic Sarcoma | X X |
Sarcoma | X |
Sarcoma, Metastatic, Skin | X X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
|__________________________________________________________________________|
Pleura | + |
Sarcoma, Metastatic, Lung | X |
|__________________________________________________________________________|
Trachea | + A + + + + + + + + + A + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Harderian Gland | + + + + + M + + + M M + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 14
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
_____________________________________________________________________________________________________________________
| 0| 2| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 8| 8| 4| 5| 4| 8| 8| 0| 0| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 8| 1| 5| 1| 5| 2| 1| 1| 3| 3| 1| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
56 MG/KG | 8| 9| 8| 8| 8| 9| 6| 7| 5| 9| 9| 7| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 8|
| 3| 0| 1| 9| 0| 7| 7| 0| 5| 9| 6| 2| 2| 3| 4| 9| 1| 3| 4| 6| 8| 9| 1| 9| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Adenoma | X X |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + A + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X X |
Sarcoma, Metastatic, Mesentery | X |
Sarcoma, Metastatic, Skin | X |
Transitional Epithelium, Carcinoma | X |
|__________________________________________________________________________|
Ureter | A |
|__________________________________________________________________________|
Urethra | + |
|__________________________________________________________________________|
Urinary Bladder | + A + + + A + + + + + A + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X X |
Lymphoma Malignant | X X X X |
__________________________________________|__________________________________________________________________________|
Page 15
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
56 MG/KG | 8| 8| 9| 9| 9| 9| 0| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| L |
| 6| 8| 1| 4| 5| 8| 0| 1| 6| 7| 8| 0| 2| 5| 3| 4| 5| 6| 7| 8| 2| 4| 7| 2| 3| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + A + + + +| 40 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +| 44 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + + +| 43 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + + +| 44 |
Polyp Adenomatous | X | 2 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + + +| 44 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A + + + +| 44 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemangiosarcoma | X | 1 |
Hepatocellular Carcinoma | X | 3 |
Hepatocellular Adenoma | X X| 3 |
Hepatocellular Adenoma, Multiple | X | 2 |
Histiocytic Sarcoma | X | 3 |
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + + + + + + + + +| 34 |
Histiocytic Sarcoma | | 1 |
Sarcoma | | 1 |
Sarcoma, Metastatic, Skin | X | 2 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + A + + + +| 45 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 16
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
56 MG/KG | 8| 8| 9| 9| 9| 9| 0| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| L |
| 6| 8| 1| 4| 5| 8| 0| 1| 6| 7| 8| 0| 2| 5| 3| 4| 5| 6| 7| 8| 2| 4| 7| 2| 3| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + A + + + +| 45 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 1 |
Pericardium, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | | 1 |
Pericardium, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Histiocytic Sarcoma | | 1 |
Sarcoma, Metastatic, Skin | X | 1 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pheochromocytoma Benign | X| 1 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + A + + + +| 45 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + M + + + + + + + + + M + + + + + +| 38 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| 47 |
Pars Distalis, Adenoma | X | 3 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 17
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
56 MG/KG | 8| 8| 9| 9| 9| 9| 0| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| L |
| 6| 8| 1| 4| 5| 8| 0| 1| 6| 7| 8| 0| 2| 5| 3| 4| 5| 6| 7| 8| 2| 4| 7| 2| 3| |
_____________________________________________________________________________________________________________________|____________|
GENERAL BODY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + M + + + + + M + + + + + + + + + + + + + + + M| 44 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + I + + + + + + + + + + + + + A + + + +| 46 |
Cystadenoma | | 1 |
Histiocytic Sarcoma | | 1 |
Luteoma | | 1 |
Sarcoma, Metastatic, Mesentery | | 1 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Histiocytic Sarcoma | | 2 |
Polyp Stromal | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hemangiosarcoma | X | 1 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + | 10 |
Bronchial, Histiocytic Sarcoma | | 2 |
Lumbar, Histiocytic Sarcoma | | 1 |
Mediastinal, Histiocytic Sarcoma | X | 2 |
Renal, Sarcoma, Metastatic, Skin | X | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + M + + + M + M + + + + + M M + +| 38 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 18
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
56 MG/KG | 8| 8| 9| 9| 9| 9| 0| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| L |
| 6| 8| 1| 4| 5| 8| 0| 1| 6| 7| 8| 0| 2| 5| 3| 4| 5| 6| 7| 8| 2| 4| 7| 2| 3| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + A + + + +| 44 |
Histiocytic Sarcoma | | 1 |
Sarcoma, Metastatic, Mesentery | | 1 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hemangiosarcoma | X | 1 |
Histiocytic Sarcoma | X | 1 |
|__________________________________________________________________________|____________|
Thymus | + + M + M + M M + + + M M + + + + + + + A + + + +| 38 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Histiocytic | | |
Sarcoma | | 1 |
Subcutaneous Tissue, Sarcoma | X | 4 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Histiocytic Sarcoma | | 2 |
Sarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 19
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
56 MG/KG | 8| 8| 9| 9| 9| 9| 0| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| L |
| 6| 8| 1| 4| 5| 8| 0| 1| 6| 7| 8| 0| 2| 5| 3| 4| 5| 6| 7| 8| 2| 4| 7| 2| 3| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar/Bronchiolar Adenoma | X | 2 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 1 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Histiocytic Sarcoma | X | 3 |
Sarcoma | | 1 |
Sarcoma, Metastatic, Skin | X | 3 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Pleura | | 1 |
Sarcoma, Metastatic, Lung | | 1 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Harderian Gland | + + M M + M M + + + + + + + + + + + + + + + + M M| 41 |
Adenoma | X | 3 |
Carcinoma | X X | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Histiocytic Sarcoma | X | 4 |
Sarcoma, Metastatic, Mesentery | | 1 |
Sarcoma, Metastatic, Skin | | 1 |
Transitional Epithelium, Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Ureter | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 20
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
56 MG/KG | 8| 8| 9| 9| 9| 9| 0| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| L |
| 6| 8| 1| 4| 5| 8| 0| 1| 6| 7| 8| 0| 2| 5| 3| 4| 5| 6| 7| 8| 2| 4| 7| 2| 3| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
| | |
Urethra | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + A + + + +| 46 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 4 |
Lymphoma Malignant | X X X X | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 21
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
_____________________________________________________________________________________________________________________
| 3| 4| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 8| 0| 8| 0| 2| 3| 3| 4| 5| 6| 7| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 3| 1| 9| 9| 3| 1| 8| 8| 7| 3| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
168 | 0| 1| 2| 3| 2| 4| 0| 1| 2| 4| 3| 3| 1| 0| 0| 0| 0| 0| 1| 1| 3| 3| 3| 3| 3|
MG/KG | 3| 3| 7| 5| 2| 8| 7| 7| 9| 4| 8| 9| 9| 1| 2| 4| 5| 8| 5| 8| 0| 1| 3| 4| 7|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + M A A + A A + A A A + + + + + + M I + + + +|
Sarcoma, Metastatic, Uterus | X |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + A + A A + + A A A + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + A A + + A A A + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A A A + A A A + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A A A A A + A A A + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A A A A A + A A A + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + A A A A A + A A A + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | X |
Hepatocellular Adenoma, Multiple | |
Histiocytic Sarcoma | |
Osteosarcoma, Metastatic, Uncertain | |
Primary Site | X |
Sarcoma, Metastatic, Skin | X |
Sarcoma, Metastatic, Uterus | X |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + +|
Sarcoma, Metastatic, Skin | X |
Sarcoma, Metastatic, Uterus | X |
|__________________________________________________________________________|
Pancreas | + + + + A + + A + + A M + + + + + + + + + + + + +|
Sarcoma, Metastatic, Skin | X |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 22
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
_____________________________________________________________________________________________________________________
| 3| 4| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 8| 0| 8| 0| 2| 3| 3| 4| 5| 6| 7| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 3| 1| 9| 9| 3| 1| 8| 8| 7| 3| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
168 | 0| 1| 2| 3| 2| 4| 0| 1| 2| 4| 3| 3| 1| 0| 0| 0| 0| 0| 1| 1| 3| 3| 3| 3| 3|
MG/KG | 3| 3| 7| 5| 2| 8| 7| 7| 9| 4| 8| 9| 9| 1| 2| 4| 5| 8| 5| 8| 0| 1| 3| 4| 7|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + A + + + + + + + + + + + + + +|
Sarcoma, Metastatic, Skin | X |
|__________________________________________________________________________|
Stomach, Glandular | + + + + A A + A + + A A A + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + A + + + + + + + + + + + + + + + + + + + +|
Subcapsular, Carcinoma | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + A + + M + + + + M + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + A + + A + + A M A + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + M + I + + + M + M + M + + + I + + M + + +|
|__________________________________________________________________________|
Pituitary Gland | + + I + + + + I I + + + A + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X |
Pars Intermedia, Adenoma | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + A + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | + |
Sarcoma, Metastatic, Skin | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | I I M + + + M + + + + + + + M + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 23
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
_____________________________________________________________________________________________________________________
| 3| 4| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 8| 0| 8| 0| 2| 3| 3| 4| 5| 6| 7| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 3| 1| 9| 9| 3| 1| 8| 8| 7| 3| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
168 | 0| 1| 2| 3| 2| 4| 0| 1| 2| 4| 3| 3| 1| 0| 0| 0| 0| 0| 1| 1| 3| 3| 3| 3| 3|
MG/KG | 3| 3| 7| 5| 2| 8| 7| 7| 9| 4| 8| 9| 9| 1| 2| 4| 5| 8| 5| 8| 0| 1| 3| 4| 7|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Ovary | + + + + + + + + + + A + A + + + + + + + + + + + +|
Cystadenoma | X X |
Hemangiosarcoma | X |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
|__________________________________________________________________________|
Lymph Node | + + + + + |
Bronchial, Osteosarcoma, Metastatic, | |
Uncertain Primary Site | X |
Mediastinal, Osteosarcoma, | |
Metastatic, Uncertain Primary | |
Site | X |
|__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + M + M + + + M M M + M + + + + + M + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + A + A A + + A A A + + + + + + + + + + + M|
|__________________________________________________________________________|
Spleen | + + + + + + + A + + A M + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
|__________________________________________________________________________|
Thymus | + + + + A + M + + + + M A + + + + + M M + + + + +|
Osteosarcoma, Metastatic, Uncertain | |
Primary Site | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 24
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
_____________________________________________________________________________________________________________________
| 3| 4| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 8| 0| 8| 0| 2| 3| 3| 4| 5| 6| 7| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 3| 1| 9| 9| 3| 1| 8| 8| 7| 3| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
168 | 0| 1| 2| 3| 2| 4| 0| 1| 2| 4| 3| 3| 1| 0| 0| 0| 0| 0| 1| 1| 3| 3| 3| 3| 3|
MG/KG | 3| 3| 7| 5| 2| 8| 7| 7| 9| 4| 8| 9| 9| 1| 2| 4| 5| 8| 5| 8| 0| 1| 3| 4| 7|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Sarcoma, Metastatic, Uterus | X |
Subcutaneous Tissue, Hemangiosarcoma | X |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Harderian | |
Gland | X |
|__________________________________________________________________________|
Skeletal Muscle | + + |
Osteosarcoma, Metastatic, Uncertain | |
Primary Site | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Carcinoma | X |
Carcinoma, Metastatic, Harderian | |
Gland | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | |
Osteosarcoma, Metastatic, Uncertain | |
Primary Site | X |
Sarcoma, Metastatic, Skin | X |
Mediastinum, Osteosarcoma, | |
Metastatic, Uncertain Primary | |
Site | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 25
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
_____________________________________________________________________________________________________________________
| 3| 4| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 8| 0| 8| 0| 2| 3| 3| 4| 5| 6| 7| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 3| 1| 9| 9| 3| 1| 8| 8| 7| 3| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
168 | 0| 1| 2| 3| 2| 4| 0| 1| 2| 4| 3| 3| 1| 0| 0| 0| 0| 0| 1| 1| 3| 3| 3| 3| 3|
MG/KG | 3| 3| 7| 5| 2| 8| 7| 7| 9| 4| 8| 9| 9| 1| 2| 4| 5| 8| 5| 8| 0| 1| 3| 4| 7|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Trachea | + + + + A + + + + + A A A + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + A + + + + + + + A + + + + + + + + + + + +|
Histiocytic Sarcoma | |
|__________________________________________________________________________|
Urinary Bladder | + + + + A + + + A + + + A + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X |
__________________________________________|__________________________________________________________________________|
Page 26
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
168 | 4| 4| 4| 4| 5| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| L |
MG/KG | 1| 5| 7| 9| 0| 6| 9| 0| 1| 2| 4| 6| 0| 1| 3| 4| 5| 6| 8| 2| 6| 0| 2| 3| 6| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + M + + M + + + + + + + + + + + + + +| 38 |
Sarcoma, Metastatic, Uterus | | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 44 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 44 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 44 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 42 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 42 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 42 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X | 1 |
Hepatocellular Carcinoma | X X X X | 5 |
Hepatocellular Adenoma | X | 2 |
Hepatocellular Adenoma, Multiple | X X | 2 |
Histiocytic Sarcoma | X | 1 |
Osteosarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
Sarcoma, Metastatic, Skin | X | 2 |
Sarcoma, Metastatic, Uterus | | 1 |
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + + + + + + + + | 32 |
Sarcoma, Metastatic, Skin | X | 2 |
Sarcoma, Metastatic, Uterus | | 1 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 27
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
168 | 4| 4| 4| 4| 5| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| L |
MG/KG | 1| 5| 7| 9| 0| 6| 9| 0| 1| 2| 4| 6| 0| 1| 3| 4| 5| 6| 8| 2| 6| 0| 2| 3| 6| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Sarcoma, Metastatic, Skin | | 1 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Sarcoma, Metastatic, Skin | | 1 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 44 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Subcapsular, Carcinoma | X | 1 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M M + + + + M + M M + + M + + +| 37 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 45 |
Pars Distalis, Adenoma | X X | 4 |
Pars Intermedia, Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 28
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
168 | 4| 4| 4| 4| 5| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| L |
MG/KG | 1| 5| 7| 9| 0| 6| 9| 0| 1| 2| 4| 6| 0| 1| 3| 4| 5| 6| 8| 2| 6| 0| 2| 3| 6| |
_____________________________________________________________________________________________________________________|____________|
GENERAL BODY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Peritoneum | | 1 |
Sarcoma, Metastatic, Skin | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + M + + + + + + + M I + + +| 42 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + I| 47 |
Cystadenoma | | 2 |
Hemangiosarcoma | | 1 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Polyp Stromal | X | 2 |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
|__________________________________________________________________________|____________|
Lymph Node | | 5 |
Bronchial, Osteosarcoma, Metastatic, | | |
Uncertain Primary Site | | 1 |
Mediastinal, Osteosarcoma, | | |
Metastatic, Uncertain Primary | | |
Site | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + M + + + + + + + + + + M + + + + M + + + M| 37 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 42 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 29
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
168 | 4| 4| 4| 4| 5| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| L |
MG/KG | 1| 5| 7| 9| 0| 6| 9| 0| 1| 2| 4| 6| 0| 1| 3| 4| 5| 6| 8| 2| 6| 0| 2| 3| 6| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Histiocytic Sarcoma | X | 1 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + I + + + + + + + + + + + +| 43 |
Osteosarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Sarcoma, Metastatic, Uterus | | 1 |
Subcutaneous Tissue, Hemangiosarcoma | | 1 |
Subcutaneous Tissue, Sarcoma | X | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Harderian | | |
Gland | | 1 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
Osteosarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 30
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
168 | 4| 4| 4| 4| 5| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| L |
MG/KG | 1| 5| 7| 9| 0| 6| 9| 0| 1| 2| 4| 6| 0| 1| 3| 4| 5| 6| 8| 2| 6| 0| 2| 3| 6| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X | 2 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Carcinoma, Metastatic, Harderian | | |
Gland | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 2 |
Histiocytic Sarcoma | X | 1 |
Osteosarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
Sarcoma, Metastatic, Skin | X | 2 |
Mediastinum, Osteosarcoma, | | |
Metastatic, Uncertain Primary | | |
Site | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | | 1 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 4 |
Carcinoma | X | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Histiocytic Sarcoma | X | 1 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 31
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
168 | 4| 4| 4| 4| 5| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| L |
MG/KG | 1| 5| 7| 9| 0| 6| 9| 0| 1| 2| 4| 6| 0| 1| 3| 4| 5| 6| 8| 2| 6| 0| 2| 3| 6| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
| | |
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant | X X X | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 0| 1| 7| 2| 4| 5| 6| 6| 8| 9| 0| 0| 0| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 9| 7| 9| 1| 5| 2| 0| 1| 3| 8| 1| 3| 8| 7| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
504 | 7| 7| 5| 8| 7| 9| 7| 5| 6| 8| 8| 7| 5| 6| 6| 7| 5| 5| 5| 5| 6| 6| 7| 7| 8|
MG/KG | 1| 2| 1| 2| 4| 5| 6| 4| 5| 0| 9| 9| 3| 1| 3| 0| 2| 5| 7| 9| 2| 8| 7| 8| 4|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + A + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + A + + A A A + A A A + A + A + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + A + + + + + A + A + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + I + + A + + + + + + + A + A + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + A + + A A A + + A + + A + A + + + + + + + + +|
Leiomyoma | |
|__________________________________________________________________________|
Intestine Small, Duodenum | M + A + + A A A + A + + + A + A + + + + + + + + +|
Polyp Adenomatous | X |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A A A + A A A + A + A + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + A + + A A A + A + A + A + A + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + A + + + + + + + + + + +|
Hemangiosarcoma | X X |
Hepatocellular Carcinoma | X X X |
Hepatocellular Adenoma | X X X X X X |
Hepatocellular Adenoma, Multiple | X X |
Histiocytic Sarcoma | X |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Histiocytic Sarcoma | X |
Sarcoma, Metastatic, Skin | X |
|__________________________________________________________________________|
Pancreas | + + + + + A + A + + + + + A + A + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + M + + + + + + + M + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + A + + + + + + + + + A + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 33
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 0| 1| 7| 2| 4| 5| 6| 6| 8| 9| 0| 0| 0| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 9| 7| 9| 1| 5| 2| 0| 1| 3| 8| 1| 3| 8| 7| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
504 | 7| 7| 5| 8| 7| 9| 7| 5| 6| 8| 8| 7| 5| 6| 6| 7| 5| 5| 5| 5| 6| 6| 7| 7| 8|
MG/KG | 1| 2| 1| 2| 4| 5| 6| 4| 5| 0| 9| 9| 3| 1| 3| 0| 2| 5| 7| 9| 2| 8| 7| 8| 4|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Stomach, Glandular | + + + + + A + A + + + + + A + A + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + A + + + + + + + A + + + + + + + + + + +|
Sarcoma, Metastatic, Skin | X |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + A + M + + + + + A + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + A + A + + + + + A + A + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + A + + + + M M + + + A + M + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + A + + + + + + + + + A + + + + + + + + +|
Pars Distalis, Adenoma | X |
Pars Intermedia, Adenoma | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + A + + + + + + + A + A + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | I M + + + M M I + M M + M + M M + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + M + + + + + + + + + A + + + + + + + + +|
Hemangioma | X|
Histiocytic Sarcoma | X |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X |
__________________________________________|__________________________________________________________________________|
Page 34
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 0| 1| 7| 2| 4| 5| 6| 6| 8| 9| 0| 0| 0| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 9| 7| 9| 1| 5| 2| 0| 1| 3| 8| 1| 3| 8| 7| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
504 | 7| 7| 5| 8| 7| 9| 7| 5| 6| 8| 8| 7| 5| 6| 6| 7| 5| 5| 5| 5| 6| 6| 7| 7| 8|
MG/KG | 1| 2| 1| 2| 4| 5| 6| 4| 5| 0| 9| 9| 3| 1| 3| 0| 2| 5| 7| 9| 2| 8| 7| 8| 4|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + A + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X |
|__________________________________________________________________________|
Lymph Node | + + + A |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M M M + + + + + M + I + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + A + A M + + + + A + A + + + + + + + + +|
Histiocytic Sarcoma | |
|__________________________________________________________________________|
Spleen | + + + + + A + A + + + + + A + A + + + + + + + + +|
Histiocytic Sarcoma | X |
|__________________________________________________________________________|
Thymus | M + + + + A + A + + M + M + + M + M + + + + + + +|
Sarcoma, Metastatic, Skin | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Hemangioma | X |
Subcutaneous Tissue, Histiocytic | |
Sarcoma | X |
Subcutaneous Tissue, Liposarcoma | |
Subcutaneous Tissue, Myxoma | X |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteosarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 35
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 0| 1| 7| 2| 4| 5| 6| 6| 8| 9| 0| 0| 0| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 9| 7| 9| 1| 5| 2| 0| 1| 3| 8| 1| 3| 8| 7| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
504 | 7| 7| 5| 8| 7| 9| 7| 5| 6| 8| 8| 7| 5| 6| 6| 7| 5| 5| 5| 5| 6| 6| 7| 7| 8|
MG/KG | 1| 2| 1| 2| 4| 5| 6| 4| 5| 0| 9| 9| 3| 1| 3| 0| 2| 5| 7| 9| 2| 8| 7| 8| 4|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Meningioma Malignant | X |
|__________________________________________________________________________|
Peripheral Nerve | + |
|__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Carcinoma | |
Carcinoma, Metastatic, Harderian | |
Gland | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X |
Histiocytic Sarcoma | X X |
Liposarcoma, Metastatic, Skin | |
Sarcoma, Metastatic, Skin | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + A + + + + + + + + + A + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + M + + + + M + + + + + + + + + +|
Adenoma | X X |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + A A + + + + + + A + A + + + + + + + + +|
Histiocytic Sarcoma | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 36
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 0| 1| 7| 2| 4| 5| 6| 6| 8| 9| 0| 0| 0| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 9| 7| 9| 1| 5| 2| 0| 1| 3| 8| 1| 3| 8| 7| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
504 | 7| 7| 5| 8| 7| 9| 7| 5| 6| 8| 8| 7| 5| 6| 6| 7| 5| 5| 5| 5| 6| 6| 7| 7| 8|
MG/KG | 1| 2| 1| 2| 4| 5| 6| 4| 5| 0| 9| 9| 3| 1| 3| 0| 2| 5| 7| 9| 2| 8| 7| 8| 4|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Urinary Bladder | + + + + + A + A + + + + + A + + + + + + + + + M +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X |
Lymphoma Malignant | X X X X |
__________________________________________|__________________________________________________________________________|
Page 37
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
504 | 8| 9| 9| 9| 9| 9| 9| 0| 5| 5| 6| 6| 6| 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| L |
MG/KG | 8| 0| 1| 4| 6| 8| 9| 0| 6| 8| 0| 4| 6| 7| 9| 3| 5| 1| 3| 5| 6| 7| 2| 3| 7| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Gallbladder | + M + + + + + + M + + + + M + + + + + + + + + + +| 38 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 43 |
Leiomyoma | X | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 42 |
Polyp Adenomatous | | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 42 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 42 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemangiosarcoma | X X | 4 |
Hepatocellular Carcinoma | | 3 |
Hepatocellular Adenoma | X X X | 9 |
Hepatocellular Adenoma, Multiple | X X X X | 6 |
Histiocytic Sarcoma | X | 2 |
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + +| 42 |
Hemangiosarcoma | X | 1 |
Histiocytic Sarcoma | | 1 |
Sarcoma, Metastatic, Skin | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 38
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
504 | 8| 9| 9| 9| 9| 9| 9| 0| 5| 5| 6| 6| 6| 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| L |
MG/KG | 8| 0| 1| 4| 6| 8| 9| 0| 6| 8| 0| 4| 6| 7| 9| 3| 5| 1| 3| 5| 6| 7| 2| 3| 7| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Sarcoma, Metastatic, Skin | | 1 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + M + M + + M + + + + + + + + + + M + +| 40 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Adenoma | X | 2 |
Pars Intermedia, Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| 46 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 39
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
504 | 8| 9| 9| 9| 9| 9| 9| 0| 5| 5| 6| 6| 6| 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| L |
MG/KG | 8| 0| 1| 4| 6| 8| 9| 0| 6| 8| 0| 4| 6| 7| 9| 3| 5| 1| 3| 5| 6| 7| 2| 3| 7| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
Clitoral Gland | M + M + + + + + + + M + M + + + + + + + + + + + I| 35 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hemangioma | X | 2 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Polyp Stromal | X | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Histiocytic Sarcoma | X | 3 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + +| 10 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + M + M M + + M M + +| 39 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Histiocytic Sarcoma | X | 1 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Thymus | + + M + M + + + M M M + + + + + + I + + + + M + +| 36 |
Sarcoma, Metastatic, Skin | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 40
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
504 | 8| 9| 9| 9| 9| 9| 9| 0| 5| 5| 6| 6| 6| 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| L |
MG/KG | 8| 0| 1| 4| 6| 8| 9| 0| 6| 8| 0| 4| 6| 7| 9| 3| 5| 1| 3| 5| 6| 7| 2| 3| 7| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
| | |
Subcutaneous Tissue, Hemangioma | | 1 |
Subcutaneous Tissue, Histiocytic | | |
Sarcoma | | 1 |
Subcutaneous Tissue, Liposarcoma | X | 1 |
Subcutaneous Tissue, Myxoma | | 1 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Meningioma Malignant | | 1 |
|__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
|__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X | 1 |
Alveolar/Bronchiolar Carcinoma | X | 1 |
Carcinoma, Metastatic, Harderian | | |
Gland | X X | 2 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 2 |
Histiocytic Sarcoma | | 2 |
Liposarcoma, Metastatic, Skin | X | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 41
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
504 | 8| 9| 9| 9| 9| 9| 9| 0| 5| 5| 6| 6| 6| 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| L |
MG/KG | 8| 0| 1| 4| 6| 8| 9| 0| 6| 8| 0| 4| 6| 7| 9| 3| 5| 1| 3| 5| 6| 7| 2| 3| 7| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
Sarcoma, Metastatic, Skin | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + | 2 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Adenoma | X | 3 |
Carcinoma | X X | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Histiocytic Sarcoma | X | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 3 |
Lymphoma Malignant | X X X X X X X X X X X X| 16 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 42
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
_____________________________________________________________________________________________________________________
| 4| 4| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 7| 9| 9| 0| 2| 3| 4| 6| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 7| 0| 9| 6| 0| 2| 6| 4| 0| 2| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 2| 1| 3| 1| 4| 4| 2| 3| 1| 4| 0| 0| 0| 1| 1| 1| 2| 2| 2| 3| 3| 4| 4| 4|
| 3| 0| 5| 8| 2| 6| 5| 2| 6| 7| 4| 4| 6| 8| 3| 6| 9| 5| 6| 9| 7| 9| 1| 3| 7|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | A + M A + M M + + M + + + + + + M + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma, Metastatic, Liver | X |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | A + + A + + + + + A + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | A + + A + + + + A + + + + + + + + + + + + + + + +|
Carcinoma | X X X X |
Sarcoma, Metastatic, Liver | X |
|__________________________________________________________________________|
Intestine Small, Ileum | A + + A + + + + A A + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X |
Hepatoblastoma | |
Hepatocellular Carcinoma | X X X X|
Hepatocellular Carcinoma, Multiple | X X X |
Hepatocellular Adenoma | X X X X X X |
Hepatocellular Adenoma, Multiple | X X X |
Histiocytic Sarcoma | X |
|__________________________________________________________________________|
Mesentery | + + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 43
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
_____________________________________________________________________________________________________________________
| 4| 4| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 7| 9| 9| 0| 2| 3| 4| 6| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 7| 0| 9| 6| 0| 2| 6| 4| 0| 2| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 2| 1| 3| 1| 4| 4| 2| 3| 1| 4| 0| 0| 0| 1| 1| 1| 2| 2| 2| 3| 3| 4| 4| 4|
| 3| 0| 5| 8| 2| 6| 5| 2| 6| 7| 4| 4| 6| 8| 3| 6| 9| 5| 6| 9| 7| 9| 1| 3| 7|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Stomach, Glandular | A + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma, Metastatic, Liver | X |
|__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma, Metastatic, Liver | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcapsular, Adenoma | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + M + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + + + + + + + + + + + + + + M + +|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 44
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
_____________________________________________________________________________________________________________________
| 4| 4| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 7| 9| 9| 0| 2| 3| 4| 6| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 7| 0| 9| 6| 0| 2| 6| 4| 0| 2| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 2| 1| 3| 1| 4| 4| 2| 3| 1| 4| 0| 0| 0| 1| 1| 1| 2| 2| 2| 3| 3| 4| 4| 4|
| 3| 0| 5| 8| 2| 6| 5| 2| 6| 7| 4| 4| 6| 8| 3| 6| 9| 5| 6| 9| 7| 9| 1| 3| 7|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hemangiosarcoma | |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma, Metastatic, Liver | X |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X |
|__________________________________________________________________________|
Lymph Node | |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M + + + + + + M + + + + M M M + M + + M + M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + + + + + + +|
Histiocytic Sarcoma | X |
|__________________________________________________________________________|
Spleen | + + + + + + + + + A + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + + + M + + M + + M M + + + + + + + + + M + M + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Chondroma | |
__________________________________________|__________________________________________________________________________|
Page 45
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
_____________________________________________________________________________________________________________________
| 4| 4| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 7| 9| 9| 0| 2| 3| 4| 6| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 7| 0| 9| 6| 0| 2| 6| 4| 0| 2| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 2| 1| 3| 1| 4| 4| 2| 3| 1| 4| 0| 0| 0| 1| 1| 1| 2| 2| 2| 3| 3| 4| 4| 4|
| 3| 0| 5| 8| 2| 6| 5| 2| 6| 7| 4| 4| 6| 8| 3| 6| 9| 5| 6| 9| 7| 9| 1| 3| 7|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma | X X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X X X X|
Histiocytic Sarcoma | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X |
__________________________________________|__________________________________________________________________________|
Page 46
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 5| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| L |
| 0| 1| 2| 5| 7| 9| 0| 1| 4| 8| 1| 3| 4| 7| 8| 0| 1| 2| 3| 4| 5| 0| 2| 8| 9| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + M + + + M + + + + + + M + + + +| 40 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Sarcoma, Metastatic, Liver | | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + I + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Carcinoma | | 4 |
Sarcoma, Metastatic, Liver | | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | | 2 |
Hepatoblastoma | X | 1 |
Hepatocellular Carcinoma | X X X | 7 |
Hepatocellular Carcinoma, Multiple | X | 4 |
Hepatocellular Adenoma | X X X X | 10 |
Hepatocellular Adenoma, Multiple | X X X X X X | 9 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 47
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 5| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| L |
| 0| 1| 2| 5| 7| 9| 0| 1| 4| 8| 1| 3| 4| 7| 8| 0| 1| 2| 3| 4| 5| 0| 2| 8| 9| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Sarcoma, Metastatic, Liver | | 1 |
|__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + +| 33 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Sarcoma, Metastatic, Liver | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcapsular, Adenoma | X X | 2 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + + + M + M + + + + + + + + M +| 44 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 47 |
|__________________________________________________________________________|____________|
Thyroid Gland | + I + + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 48
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 5| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| L |
| 0| 1| 2| 5| 7| 9| 0| 1| 4| 8| 1| 3| 4| 7| 8| 0| 1| 2| 3| 4| 5| 0| 2| 8| 9| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemangiosarcoma | X | 1 |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Sarcoma, Metastatic, Liver | | 1 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | | 2 |
|__________________________________________________________________________|____________|
Lymph Node | + | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M + M M + + + M + + + + M + + M + + M M + M M +| 28 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Thymus | M + + + M + + + + + + + + + + + + + + + + + M + +| 40 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 49
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 5| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| L |
| 0| 1| 2| 5| 7| 9| 0| 1| 4| 8| 1| 3| 4| 7| 8| 0| 1| 2| 3| 4| 5| 0| 2| 8| 9| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M + M| 1 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + I + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Chondroma | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X X X X| 9 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 1 |
Alveolar/Bronchiolar Carcinoma | X X | 4 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | X | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X X | 7 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 50
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 5| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| L |
| 0| 1| 2| 5| 7| 9| 0| 1| 4| 8| 1| 3| 4| 7| 8| 0| 1| 2| 3| 4| 5| 0| 2| 8| 9| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenoma | X X X X | 6 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 51
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
_____________________________________________________________________________________________________________________
| 0| 3| 3| 4| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 1| 4| 5| 0| 0| 0| 8| 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 1| 6| 5| 8| 8| 8| 8| 7| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
56 MG/KG | 7| 9| 7| 8| 7| 8| 9| 8| 9| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8|
| 7| 8| 3| 0| 1| 6| 9| 3| 6| 3| 1| 2| 3| 9| 0| 1| 2| 4| 5| 0| 4| 5| 1| 2| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + A + + + A + A A + + + + + + + M + + + + + M +|
|__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + + A A + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + + A A + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + A A + + + + + + + + + + + + + + +|
Mast Cell Tumor Malignant, | |
Metastatic, Bone Marrow | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + A A + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + A + A + + + + + + + + + + + + + + + +|
Carcinoma | |
Polyp Adenomatous | |
|__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + A A + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatoblastoma | X |
Hepatocellular Carcinoma | X X X X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X X X X X |
Hepatocellular Adenoma, Multiple | X |
Mast Cell Tumor Malignant, | |
Metastatic, Bone Marrow | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
|__________________________________________________________________________|
Mesentery | + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
__________________________________________|__________________________________________________________________________|
Page 52
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
_____________________________________________________________________________________________________________________
| 0| 3| 3| 4| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 1| 4| 5| 0| 0| 0| 8| 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 1| 6| 5| 8| 8| 8| 8| 7| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
56 MG/KG | 7| 9| 7| 8| 7| 8| 9| 8| 9| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8|
| 7| 8| 3| 0| 1| 6| 9| 3| 6| 3| 1| 2| 3| 9| 0| 1| 2| 4| 5| 0| 4| 5| 1| 2| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mast Cell Tumor Malignant, | |
Metastatic, Bone Marrow | |
Squamous Cell Carcinoma | X |
|__________________________________________________________________________|
Stomach, Glandular | + + A + + + + + + + + + + + + + + + + + + + + + +|
Mast Cell Tumor Malignant, | |
Metastatic, Bone Marrow | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
|__________________________________________________________________________|
Tooth | + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mast Cell Tumor Malignant, | |
Metastatic, Bone Marrow | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + A + + M + + + + M + + + + M + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 53
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
_____________________________________________________________________________________________________________________
| 0| 3| 3| 4| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 1| 4| 5| 0| 0| 0| 8| 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 1| 6| 5| 8| 8| 8| 8| 7| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
56 MG/KG | 7| 9| 7| 8| 7| 8| 9| 8| 9| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8|
| 7| 8| 3| 0| 1| 6| 9| 3| 6| 3| 1| 2| 3| 9| 0| 1| 2| 4| 5| 0| 4| 5| 1| 2| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + A + + + + + + + + + + + + + + +|
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | |
Mast Cell Tumor Malignant, | |
Metastatic, Bone Marrow | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mast Cell Tumor Malignant | |
|__________________________________________________________________________|
Lymph Node | |
Mediastinal, Mast Cell Tumor | |
Malignant, Metastatic, Bone | |
Marrow | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 54
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
_____________________________________________________________________________________________________________________
| 0| 3| 3| 4| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 1| 4| 5| 0| 0| 0| 8| 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 1| 6| 5| 8| 8| 8| 8| 7| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
56 MG/KG | 7| 9| 7| 8| 7| 8| 9| 8| 9| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8|
| 7| 8| 3| 0| 1| 6| 9| 3| 6| 3| 1| 2| 3| 9| 0| 1| 2| 4| 5| 0| 4| 5| 1| 2| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymph Node, Mandibular | + M M + M + + + M M + M M M + M M + M M + + + + +|
Mast Cell Tumor Malignant, | |
Metastatic, Bone Marrow | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + A + + + + + + + + + + + + M + + +|
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mast Cell Tumor Malignant, | |
Metastatic, Bone Marrow | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
|__________________________________________________________________________|
Thymus | + M + + + + + M + + + M + + + + + + I M + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M + M M M M M M M M M M M M M M M M M M + M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Melanoma | |
Malignant | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mast Cell Tumor Malignant, | |
Metastatic, Bone Marrow | |
|__________________________________________________________________________|
Skeletal Muscle | + |
Mast Cell Tumor Malignant, | |
Metastatic, Bone Marrow | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
_____________________________________________________________________________________________________________________
| 0| 3| 3| 4| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 1| 4| 5| 0| 0| 0| 8| 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 1| 6| 5| 8| 8| 8| 8| 7| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
56 MG/KG | 7| 9| 7| 8| 7| 8| 9| 8| 9| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8|
| 7| 8| 3| 0| 1| 6| 9| 3| 6| 3| 1| 2| 3| 9| 0| 1| 2| 4| 5| 0| 4| 5| 1| 2| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Carcinoma | X X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Mediastinum, Mast Cell Tumor | |
Malignant, Metastatic, Bone | |
Marrow | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mast Cell Tumor Malignant, | |
Metastatic, Bone Marrow | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | |
|__________________________________________________________________________|
Harderian Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
|__________________________________________________________________________|
Urinary Bladder | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________|__________________________________________________________________________|
Page 56
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
56 MG/KG | 8| 9| 9| 9| 9| 9| 9| 0| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 9| L |
| 9| 0| 1| 2| 4| 5| 7| 0| 4| 5| 6| 7| 8| 6| 7| 8| 9| 2| 6| 8| 9| 4| 7| 8| 3| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | M + M + + I M + + + + + + + + + + + + + + I + + I| 38 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Mast Cell Tumor Malignant, | | |
Metastatic, Bone Marrow | X | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Carcinoma | X| 1 |
Polyp Adenomatous | X | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatoblastoma | | 1 |
Hepatocellular Carcinoma | X X X X X X X X| 12 |
Hepatocellular Carcinoma, Multiple | X | 1 |
Hepatocellular Adenoma | X X X X X X| 12 |
Hepatocellular Adenoma, Multiple | X X | 3 |
Mast Cell Tumor Malignant, | | |
Metastatic, Bone Marrow | X | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 1 |
|__________________________________________________________________________|____________|
Mesentery | + + + | 4 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 57
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
56 MG/KG | 8| 9| 9| 9| 9| 9| 9| 0| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 9| L |
| 9| 0| 1| 2| 4| 5| 7| 0| 4| 5| 6| 7| 8| 6| 7| 8| 9| 2| 6| 8| 9| 4| 7| 8| 3| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 1 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mast Cell Tumor Malignant, | | |
Metastatic, Bone Marrow | X | 1 |
Squamous Cell Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mast Cell Tumor Malignant, | | |
Metastatic, Bone Marrow | X | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 1 |
|__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + +| 27 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mast Cell Tumor Malignant, | | |
Metastatic, Bone Marrow | X | 1 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 58
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
56 MG/KG | 8| 9| 9| 9| 9| 9| 9| 0| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 9| L |
| 9| 0| 1| 2| 4| 5| 7| 0| 4| 5| 6| 7| 8| 6| 7| 8| 9| 2| 6| 8| 9| 4| 7| 8| 3| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
| | |
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 1 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + M + + M + + + + + + + + + + + + M +| 42 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + I + + + + + + + + + + + + + + + I + + + + + +| 48 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | + | 1 |
Mast Cell Tumor Malignant, | | |
Metastatic, Bone Marrow | X | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + I| 49 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 1 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 59
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
56 MG/KG | 8| 9| 9| 9| 9| 9| 9| 0| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 9| L |
| 9| 0| 1| 2| 4| 5| 7| 0| 4| 5| 6| 7| 8| 6| 7| 8| 9| 2| 6| 8| 9| 4| 7| 8| 3| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
Interstitial Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mast Cell Tumor Malignant | X | 1 |
|__________________________________________________________________________|____________|
Lymph Node | + | 1 |
Mediastinal, Mast Cell Tumor | | |
Malignant, Metastatic, Bone | | |
Marrow | X | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M M M + + + M + + M + M + + M M M + + +| 29 |
Mast Cell Tumor Malignant, | | |
Metastatic, Bone Marrow | X | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + M + + + + + +| 46 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 1 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mast Cell Tumor Malignant, | | |
Metastatic, Bone Marrow | X | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 1 |
|__________________________________________________________________________|____________|
Thymus | + + + M + + I M + + + M M + + + + + + + + + + + +| 39 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| 2 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 60
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
56 MG/KG | 8| 9| 9| 9| 9| 9| 9| 0| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 9| L |
| 9| 0| 1| 2| 4| 5| 7| 0| 4| 5| 6| 7| 8| 6| 7| 8| 9| 2| 6| 8| 9| 4| 7| 8| 3| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
| | |
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Melanoma | | |
Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mast Cell Tumor Malignant, | | |
Metastatic, Bone Marrow | X | 1 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
Mast Cell Tumor Malignant, | | |
Metastatic, Bone Marrow | X | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | | 3 |
Alveolar/Bronchiolar Carcinoma | X | 3 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X X| 3 |
Mediastinum, Mast Cell Tumor | | |
Malignant, Metastatic, Bone | | |
Marrow | X | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 61
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
56 MG/KG | 8| 9| 9| 9| 9| 9| 9| 0| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 9| L |
| 9| 0| 1| 2| 4| 5| 7| 0| 4| 5| 6| 7| 8| 6| 7| 8| 9| 2| 6| 8| 9| 4| 7| 8| 3| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
Mast Cell Tumor Malignant, | | |
Metastatic, Bone Marrow | X | 1 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + | 1 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Adenoma | X X X X X X | 9 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 62
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 4| 8| 9| 9| 1| 2| 4| 5| 5| 8| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 8| 1| 2| 7| 1| 0| 1| 3| 3| 0| 5| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
168 | 2| 0| 1| 1| 3| 2| 4| 3| 0| 4| 3| 5| 0| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3|
MG/KG | 6| 4| 0| 9| 9| 3| 9| 3| 8| 1| 7| 0| 9| 2| 3| 4| 5| 6| 4| 5| 8| 0| 1| 2| 4|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | A + + A A + A M + + A + + + + + + + + M + + M + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + A A + + + + + A + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | A + + A A + + + I + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | A + + A A + + + A + + + + + + + + + + + + + + + +|
Carcinoma | X |
|__________________________________________________________________________|
Intestine Small, Duodenum | A + A A A + A + + + A + + + + + + + + + + + + + +|
Carcinoma | |
|__________________________________________________________________________|
Intestine Small, Jejunum | A + A A A + + + A + A + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | A + A A A + + + A + A + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hepatocellular Carcinoma | X X X X X X |
Hepatocellular Carcinoma, Multiple | X X X |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | X X X |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + |
Sarcoma | X |
|__________________________________________________________________________|
Pancreas | + + A + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X X |
|__________________________________________________________________________|
Stomach, Glandular | + + + A A + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 63
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 4| 8| 9| 9| 1| 2| 4| 5| 5| 8| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 8| 1| 2| 7| 1| 0| 1| 3| 3| 0| 5| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
168 | 2| 0| 1| 1| 3| 2| 4| 3| 0| 4| 3| 5| 0| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3|
MG/KG | 6| 4| 0| 9| 9| 3| 9| 3| 8| 1| 7| 0| 9| 2| 3| 4| 5| 6| 4| 5| 8| 0| 1| 2| 4|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Tooth | + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | |
|__________________________________________________________________________|
Islets, Pancreatic | + + A + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + M + + + + + + + + + + + M + M + M|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 64
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 4| 8| 9| 9| 1| 2| 4| 5| 5| 8| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 8| 1| 2| 7| 1| 0| 1| 3| 3| 0| 5| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
168 | 2| 0| 1| 1| 3| 2| 4| 3| 0| 4| 3| 5| 0| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3|
MG/KG | 6| 4| 0| 9| 9| 3| 9| 3| 8| 1| 7| 0| 9| 2| 3| 4| 5| 6| 4| 5| 8| 0| 1| 2| 4|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + A + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + A + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X |
Sarcoma | |
|__________________________________________________________________________|
Lymph Node | |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M + M + + M M + M M M + + + + + M M + M M + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + A A A + + + + + A + + + + + + + + + + + + + +|
Sarcoma, Metastatic, Mesentery | X |
|__________________________________________________________________________|
Spleen | + + + + A + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
|__________________________________________________________________________|
Thymus | + + M + + + + + + + M M + + + + + + + M + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 65
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 4| 8| 9| 9| 1| 2| 4| 5| 5| 8| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 8| 1| 2| 7| 1| 0| 1| 3| 3| 0| 5| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
168 | 2| 0| 1| 1| 3| 2| 4| 3| 0| 4| 3| 5| 0| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3|
MG/KG | 6| 4| 0| 9| 9| 3| 9| 3| 8| 1| 7| 0| 9| 2| 3| 4| 5| 6| 4| 5| 8| 0| 1| 2| 4|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X |
Alveolar/Bronchiolar Carcinoma | X X X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X X X X X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + A + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + |
|__________________________________________________________________________|
Harderian Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X |
Carcinoma | |
Bilateral, Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Urinary Bladder | + + + A + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Transitional Epithelium, Papilloma | X |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________|__________________________________________________________________________|
Page 66
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
168 | 3| 3| 4| 4| 4| 4| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 3| 4| 4| 4| 4| L |
MG/KG | 5| 8| 0| 4| 6| 7| 1| 2| 3| 5| 6| 7| 1| 7| 8| 0| 1| 2| 7| 9| 6| 2| 3| 5| 8| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + M + + + M + + + I| 39 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 44 |
Carcinoma | X | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 44 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + M +| 43 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X X X | 4 |
Hepatocellular Carcinoma | X X X X X | 11 |
Hepatocellular Carcinoma, Multiple | X | 4 |
Hepatocellular Adenoma | X X X X X X X| 10 |
Hepatocellular Adenoma, Multiple | X X | 5 |
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + | 20 |
Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 67
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
168 | 3| 3| 4| 4| 4| 4| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 3| 4| 4| 4| 4| L |
MG/KG | 5| 8| 0| 4| 6| 7| 1| 2| 3| 5| 6| 7| 1| 7| 8| 0| 1| 2| 7| 9| 6| 2| 3| 5| 8| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Squamous Cell Papilloma | | 2 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + | 30 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | | 1 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pheochromocytoma Benign | X | 1 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenoma | X | 2 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M + + + M M M + + M M + I + + M +| 37 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 68
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
168 | 3| 3| 4| 4| 4| 4| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 3| 4| 4| 4| 4| L |
MG/KG | 5| 8| 0| 4| 6| 7| 1| 2| 3| 5| 6| 7| 1| 7| 8| 0| 1| 2| 7| 9| 6| 2| 3| 5| 8| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemangiosarcoma | | 2 |
Sarcoma | X | 1 |
|__________________________________________________________________________|____________|
Lymph Node | + | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + M M + + + + + M M + + + M M M + + + +| 30 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + + + + + + + +| 45 |
Sarcoma, Metastatic, Mesentery | | 1 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemangiosarcoma | X | 1 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + I + + + + M M + M + + + + + M M| 39 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 69
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
168 | 3| 3| 4| 4| 4| 4| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 3| 4| 4| 4| 4| L |
MG/KG | 5| 8| 0| 4| 6| 7| 1| 2| 3| 5| 6| 7| 1| 7| 8| 0| 1| 2| 7| 9| 6| 2| 3| 5| 8| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
| | |
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Keratoacanthoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X X | 8 |
Alveolar/Bronchiolar Carcinoma | X X | 5 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X X X X | 10 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | +| 2 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenoma | X | 4 |
Carcinoma | X| 1 |
Bilateral, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 70
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
168 | 3| 3| 4| 4| 4| 4| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 3| 4| 4| 4| 4| L |
MG/KG | 5| 8| 0| 4| 6| 7| 1| 2| 3| 5| 6| 7| 1| 7| 8| 0| 1| 2| 7| 9| 6| 2| 3| 5| 8| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemangiosarcoma | | 1 |
Transitional Epithelium, Papilloma | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 71
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
_____________________________________________________________________________________________________________________
| 0| 0| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 1| 8| 9| 9| 3| 7| 8| 9| 1| 2| 2| 3| 4| 5| 5| 6| 7| 9| 2| 3| 3| 3| 3| 3|
| 1| 7| 3| 2| 8| 9| 6| 4| 0| 7| 1| 6| 1| 6| 7| 8| 8| 6| 5| 1| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
504 | 9| 5| 6| 7| 8| 7| 6| 0| 6| 6| 5| 6| 8| 5| 5| 5| 7| 5| 9| 7| 5| 6| 6| 7| 7|
MG/KG | 0| 7| 2| 6| 2| 1| 5| 0| 7| 0| 4| 3| 8| 8| 5| 9| 8| 1| 1| 9| 3| 1| 4| 0| 2|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + A + A + A + + + A A M + A A A M A A + M + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + A + + + A + + + A + + A + A A + A A + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + + A A + + A + A A + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + A A A + A + + + A A + A + A A + A A + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + A A + + A + + + A A + A + A A + A A + + + + + +|
Polyp Adenomatous | |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + A A + A + + + A A A A + A A A A A + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + A A A + A + + + A A A A + A A + A A + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X X X X |
Hepatocellular Carcinoma | X X X X X X X |
Hepatocellular Carcinoma, Multiple | X X |
Hepatocellular Adenoma | X X |
Hepatocellular Adenoma, Multiple | X X X X X |
Histiocytic Sarcoma | X X |
|__________________________________________________________________________|
Mesentery | + + +|
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + I + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + A + + + + + + + A + + + A + + + A + + + + + +|
|__________________________________________________________________________|
Tooth | + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 72
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
_____________________________________________________________________________________________________________________
| 0| 0| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 1| 8| 9| 9| 3| 7| 8| 9| 1| 2| 2| 3| 4| 5| 5| 6| 7| 9| 2| 3| 3| 3| 3| 3|
| 1| 7| 3| 2| 8| 9| 6| 4| 0| 7| 1| 6| 1| 6| 7| 8| 8| 6| 5| 1| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
504 | 9| 5| 6| 7| 8| 7| 6| 0| 6| 6| 5| 6| 8| 5| 5| 5| 7| 5| 9| 7| 5| 6| 6| 7| 7|
MG/KG | 0| 7| 2| 6| 2| 1| 5| 0| 7| 0| 4| 3| 8| 8| 5| 9| 8| 1| 1| 9| 3| 1| 4| 0| 2|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + M + + + + M + + M + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + I + + + + +|
Pars Intermedia, Adenoma | |
|__________________________________________________________________________|
Thyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
_____________________________________________________________________________________________________________________
| 0| 0| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 1| 8| 9| 9| 3| 7| 8| 9| 1| 2| 2| 3| 4| 5| 5| 6| 7| 9| 2| 3| 3| 3| 3| 3|
| 1| 7| 3| 2| 8| 9| 6| 4| 0| 7| 1| 6| 1| 6| 7| 8| 8| 6| 5| 1| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
504 | 9| 5| 6| 7| 8| 7| 6| 0| 6| 6| 5| 6| 8| 5| 5| 5| 7| 5| 9| 7| 5| 6| 6| 7| 7|
MG/KG | 0| 7| 2| 6| 2| 1| 5| 0| 7| 0| 4| 3| 8| 8| 5| 9| 8| 1| 1| 9| 3| 1| 4| 0| 2|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Histiocytic Sarcoma | X X |
|__________________________________________________________________________|
Lymph Node | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M M M + M + + + + M M M M + + + + + + M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + A + A + + + + + + A + A + A A + A A M + + + + +|
Hemangiosarcoma | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + A + + + + + + + + + +|
Hemangiosarcoma | X |
Histiocytic Sarcoma | X |
|__________________________________________________________________________|
Thymus | + + + + M M + M M M + + + M + M + M M M + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibrous | |
Histiocytoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 74
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
_____________________________________________________________________________________________________________________
| 0| 0| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 1| 8| 9| 9| 3| 7| 8| 9| 1| 2| 2| 3| 4| 5| 5| 6| 7| 9| 2| 3| 3| 3| 3| 3|
| 1| 7| 3| 2| 8| 9| 6| 4| 0| 7| 1| 6| 1| 6| 7| 8| 8| 6| 5| 1| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
504 | 9| 5| 6| 7| 8| 7| 6| 0| 6| 6| 5| 6| 8| 5| 5| 5| 7| 5| 9| 7| 5| 6| 6| 7| 7|
MG/KG | 0| 7| 2| 6| 2| 1| 5| 0| 7| 0| 4| 3| 8| 8| 5| 9| 8| 1| 1| 9| 3| 1| 4| 0| 2|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Carcinoma, Metastatic, Harderian | |
Gland | X |
|__________________________________________________________________________|
Spinal Cord | +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X |
Alveolar/Bronchiolar Carcinoma | X X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X X X |
|__________________________________________________________________________|
Nose | + A + + + + + + + + + + + + + + + A + + + + + +|
|__________________________________________________________________________|
Pleura | + |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + M + + + + + + + + + + + + + + +|
Adenoma | X X X X |
Carcinoma | X |
|__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + A + + + + + + + + + +|
Histiocytic Sarcoma | X |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 75
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
_____________________________________________________________________________________________________________________
| 0| 0| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 1| 8| 9| 9| 3| 7| 8| 9| 1| 2| 2| 3| 4| 5| 5| 6| 7| 9| 2| 3| 3| 3| 3| 3|
| 1| 7| 3| 2| 8| 9| 6| 4| 0| 7| 1| 6| 1| 6| 7| 8| 8| 6| 5| 1| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
504 | 9| 5| 6| 7| 8| 7| 6| 0| 6| 6| 5| 6| 8| 5| 5| 5| 7| 5| 9| 7| 5| 6| 6| 7| 7|
MG/KG | 0| 7| 2| 6| 2| 1| 5| 0| 7| 0| 4| 3| 8| 8| 5| 9| 8| 1| 1| 9| 3| 1| 4| 0| 2|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Urinary Bladder | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X X |
Lymphoma Malignant | |
__________________________________________|__________________________________________________________________________|
Page 76
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
504 | 7| 7| 8| 8| 8| 9| 9| 9| 9| 9| 9| 5| 5| 6| 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| L |
MG/KG | 3| 7| 0| 4| 5| 2| 4| 5| 7| 8| 9| 2| 6| 6| 8| 9| 4| 5| 1| 3| 6| 7| 9| 3| 6| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | I M + + + + + + + + + + + + + + + + M + + + + + +| 34 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 42 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 44 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 39 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 40 |
Polyp Adenomatous | X | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 38 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 38 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X X X X| 9 |
Hepatocellular Carcinoma | X X X X | 11 |
Hepatocellular Carcinoma, Multiple | | 2 |
Hepatocellular Adenoma | X X X X X X X X| 10 |
Hepatocellular Adenoma, Multiple | X X X X X | 10 |
Histiocytic Sarcoma | | 2 |
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 77
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
504 | 7| 7| 8| 8| 8| 9| 9| 9| 9| 9| 9| 5| 5| 6| 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| L |
MG/KG | 3| 7| 0| 4| 5| 2| 4| 5| 7| 8| 9| 2| 6| 6| 8| 9| 4| 5| 1| 3| 6| 7| 9| 3| 6| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + +| 23 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | I + + + + + M + + + + + M I + + + + M + + + + M +| 40 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pars Intermedia, Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 78
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
504 | 7| 7| 8| 8| 8| 9| 9| 9| 9| 9| 9| 5| 5| 6| 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| L |
MG/KG | 3| 7| 0| 4| 5| 2| 4| 5| 7| 8| 9| 2| 6| 6| 8| 9| 4| 5| 1| 3| 6| 7| 9| 3| 6| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X | 1 |
Histiocytic Sarcoma | | 2 |
|__________________________________________________________________________|____________|
Lymph Node | + | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + + + M M + + M + + + M + + + M M M M + M| 30 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 41 |
Hemangiosarcoma | X | 1 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemangiosarcoma | X | 2 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Thymus | M M + + + + + M M M + + + + + + M + + + + + + M +| 33 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 79
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
504 | 7| 7| 8| 8| 8| 9| 9| 9| 9| 9| 9| 5| 5| 6| 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| L |
MG/KG | 3| 7| 0| 4| 5| 2| 4| 5| 7| 8| 9| 2| 6| 6| 8| 9| 4| 5| 1| 3| 6| 7| 9| 3| 6| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
| | |
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Fibrous | | |
Histiocytoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Harderian | | |
Gland | | 1 |
|__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X | 5 |
Alveolar/Bronchiolar Carcinoma | X X | 4 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 5 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 80
NTP Experiment-Test: 88122-07 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC ELMIRON Date: 04/23/01
Route: GAVAGE Time: 16:05:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
504 | 7| 7| 8| 8| 8| 9| 9| 9| 9| 9| 9| 5| 5| 6| 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| L |
MG/KG | 3| 7| 0| 4| 5| 2| 4| 5| 7| 8| 9| 2| 6| 6| 8| 9| 4| 5| 1| 3| 6| 7| 9| 3| 6| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
Pleura | | 1 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | | 1 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Adenoma | X X | 6 |
Carcinoma | X | 2 |
|__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 3 |
Lymphoma Malignant | X X X X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 81
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