TDMS Study 88124-01 Pathology Tables
NTP Experiment-Test: 88124-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:02:40
FINAL#2, 13 WEEK SUBCHRONIC
Facility: Battelle Northwest
Chemical CAS #: 22398-80-7
Lock Date: 01/24/96
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 88124-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:02:40
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 1.0 3.0 10.0 30.0 100.0
MG/M3 MG/M3 MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Survivors
Terminal Sacrifice 10 10 10 10 10 10
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (1) (2) (1) (2) (10)
Hepatodiaphragmatic Nodule 1 (10%) 1 (100%) 2 (100%) 1 (100%) 2 (100%) 7 (70%)
Necrosis 1 (10%)
Pigmentation, Hemosiderin 6 (60%)
Hepatocyte, Centrilobular, Atrophy 8 (80%)
Hepatocyte, Centrilobular, Necrosis 9 (90%)
Mesentery (1) (1)
Fat, Necrosis 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (10) (10) (10) (10) (10)
Cardiomyopathy 3 (30%) 1 (10%) 1 (10%) 2 (20%) 3 (30%)
Hypertrophy 10 (100%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10) (10) (10)
Hemorrhage 1 (10%)
Zona Fasciculata, Vacuolization Cytoplasmic 1 (10%) 4 (40%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (10) (10)
Inflammation, Chronic 1 (10%)
Ovary (10) (10) (10) (10) (10) (10)
Atrophy 10 (100%)
Cyst 1 (10%) 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88124-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:02:40
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 1.0 3.0 10.0 30.0 100.0
MG/M3 MG/M3 MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Periovarian Tissue, Cyst 1 (10%)
Uterus (10) (10) (10) (10) (10) (10)
Atrophy 10 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (10) (10) (10) (10) (10) (10)
Hyperplasia 3 (30%) 10 (100%)
Inflammation, Granulomatous 2 (20%) 1 (10%) 1 (10%) 1 (10%)
Lymph Node, Bronchial (7) (9) (10) (10) (10) (9)
Hyperplasia 7 (78%) 7 (70%) 9 (90%) 10 (100%) 5 (56%)
Pigmentation 8 (89%) 10 (100%) 9 (90%) 10 (100%) 9 (100%)
Lymph Node, Mandibular (9) (9) (9)
Atrophy 5 (56%)
Lymph Node, Mesenteric (10) (9) (10) (10) (10) (9)
Inflammation, Granulomatous 1 (10%)
Lymph Node, Mediastinal (7) (9) (8) (5) (9) (8)
Atrophy 1 (13%)
Hyperplasia 8 (89%) 8 (100%) 4 (80%) 5 (56%) 7 (88%)
Pigmentation 8 (89%) 8 (100%) 5 (100%) 7 (78%) 8 (100%)
Spleen (10) (10) (10) (10) (10) (10)
Hematopoietic Cell Proliferation 9 (90%)
Thymus (10) (10) (10) (10) (10) (9)
Atrophy 9 (100%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88124-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:02:40
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 1.0 3.0 10.0 30.0 100.0
MG/M3 MG/M3 MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (10) (10) (10) (10) (10) (10)
Foreign Body 10 (100%) 10 (100%) 10 (100%) 9 (90%) 9 (90%)
Hyperplasia 1 (10%)
Inflammation, Acute 1 (10%)
Inflammation, Chronic 2 (20%) 6 (60%) 9 (90%) 9 (90%)
Lung (10) (10) (10) (10) (10) (10)
Foreign Body 9 (90%) 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Inflammation, Chronic Active 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Alveolar Epithelium, Hyperplasia 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Alveolus, Infiltration Cellular, Histiocyte 3 (30%)
Alveolus, Proteinosis 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Interstitium, Fibrosis 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Nose (10) (10) (10) (10) (10) (10)
Foreign Body 3 (30%) 2 (20%) 7 (70%) 9 (90%) 10 (100%)
Inflammation, Chronic 1 (10%) 1 (10%) 3 (30%)
Nasolacrimal Duct, Inflammation, Acute 1 (10%)
Trachea (10) (10) (10) (10) (10) (10)
Foreign Body 3 (30%) 7 (70%) 7 (70%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10) (10) (10)
Mineralization 10 (100%) 8 (80%) 9 (90%) 9 (90%) 8 (80%) 7 (70%)
Nephropathy 1 (10%) 1 (10%) 1 (10%) 10 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88124-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:02:40
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 1.0 3.0 10.0 30.0 100.0
MG/M3 MG/M3 MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Natural Death 1
Survivors
Terminal Sacrifice 10 10 10 10 10 9
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (1) (1) (1) (10)
Eosinophilic Focus 1 (10%)
Hematopoietic Cell Proliferation 1 (10%)
Hepatodiaphragmatic Nodule 1 (10%) 1 (100%) 1 (100%) 1 (100%) 4 (40%)
Infiltration Cellular, Mononuclear Cell 1 (10%)
Pigmentation, Hemosiderin 2 (20%)
Bile Duct, Hyperplasia 2 (20%)
Hepatocyte, Centrilobular, Atrophy 6 (60%)
Hepatocyte, Centrilobular, Necrosis 5 (50%)
Mesentery (1) (1)
Fat, Necrosis 1 (100%) 1 (100%)
Pancreas (10) (10)
Acinus, Atrophy 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (10) (10) (10) (10) (10)
Cardiomyopathy 6 (60%) 7 (70%) 6 (60%) 3 (30%) 5 (50%) 2 (20%)
Hypertrophy 8 (80%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10) (10) (10)
Zona Fasciculata, Vacuolization Cytoplasmic 10 (100%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88124-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:02:40
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 1.0 3.0 10.0 30.0 100.0
MG/M3 MG/M3 MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (10) (10) (10) (10) (10) (10)
Degeneration 10 (100%)
Prostate (10) (10) (10) (10) (10) (10)
Atrophy 10 (100%)
Seminal Vesicle (10) (10) (10) (10) (10) (9)
Atrophy 9 (100%)
Testes (10) (10) (10) (10) (10) (10)
Mineralization 1 (10%)
Germinal Epithelium, Degeneration 5 (50%)
Sertoli Cell, Degeneration 1 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (10) (10) (10) (10) (10) (10)
Hyperplasia 10 (100%)
Lymph Node, Bronchial (9) (10) (8) (10) (10) (9)
Hyperplasia 5 (50%) 4 (50%) 3 (30%) 6 (60%) 3 (33%)
Pigmentation 9 (90%) 8 (100%) 10 (100%) 10 (100%) 9 (100%)
Lymph Node, Mandibular (10) (8) (10)
Atrophy 6 (60%)
Lymph Node, Mediastinal (9) (5) (8) (10) (8) (10)
Hyperplasia 3 (60%) 7 (88%) 8 (80%) 6 (75%) 8 (80%)
Pigmentation 4 (80%) 8 (100%) 9 (90%) 7 (88%) 9 (90%)
Spleen (10) (10) (10) (10) (10) (10)
Hematopoietic Cell Proliferation 10 (100%)
Thymus (10) (10) (10) (10) (10) (9)
Atrophy 8 (89%)
Hemorrhage 1 (10%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (10) (1) (10)
Ulcer 1 (100%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88124-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:02:40
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 1.0 3.0 10.0 30.0 100.0
MG/M3 MG/M3 MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (10) (10) (10) (10) (10) (10)
Foreign Body 10 (100%) 10 (100%) 10 (100%) 10 (100%) 9 (90%)
Inflammation, Chronic 5 (50%) 8 (80%) 9 (90%)
Lung (10) (10) (10) (10) (10) (10)
Foreign Body 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Inflammation, Chronic Active 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Alveolar Epithelium, Hyperplasia 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Alveolus, Infiltration Cellular, Histiocyte 4 (40%)
Alveolus, Proteinosis 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Interstitium, Fibrosis 10 (100%) 10 (100%) 9 (90%) 10 (100%)
Serosa, Hemorrhage 1 (10%)
Nose (10) (10) (10) (10) (10) (10)
Foreign Body 1 (10%) 1 (10%) 8 (80%) 8 (80%) 10 (100%)
Trachea (10) (10) (10) (10) (10) (10)
Foreign Body 1 (10%) 2 (20%) 5 (50%) 8 (80%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10) (10) (10)
Nephropathy 7 (70%) 4 (40%) 5 (50%) 1 (10%) 4 (40%) 10 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
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