https://ntp.niehs.nih.gov/go/5463

TDMS Study 88124-01 Pathology Tables

NTP Experiment-Test: 88124-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                  INDIUM PHOSPHIDE                                     Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:02:40
                                                  FINAL#2, 13 WEEK SUBCHRONIC
       Facility:  Battelle Northwest
       Chemical CAS #:  22398-80-7
       Lock Date:  01/24/96
       Cage Range:  All
       Reasons For Removal:    All
       Removal Date Range:     All
       Treatment Groups:       Include All
a  Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 88124-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                  INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:02:40  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      1.0          3.0          10.0         30.0         100.0           
                                                                MG/M3        MG/M3        MG/M3        MG/M3        MG/M3           
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10           10           
  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Liver                                              (10)         (1)          (2)          (1)          (2)          (10)         
      Hepatodiaphragmatic Nodule                       1 (10%)      1 (100%)     2 (100%)     1 (100%)     2 (100%)     7 (70%)     
      Necrosis                                                                                                          1 (10%)     
      Pigmentation, Hemosiderin                                                                                         6 (60%)     
      Hepatocyte, Centrilobular, Atrophy                                                                                8 (80%)     
      Hepatocyte, Centrilobular, Necrosis                                                                               9 (90%)     
   Mesentery                                                       (1)          (1)                                                 
      Fat, Necrosis                                                 1 (100%)     1 (100%)                                           
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (10)         (10)         (10)         (10)         (10)         (10)         
      Cardiomyopathy                                   3 (30%)      1 (10%)      1 (10%)      2 (20%)      3 (30%)                  
      Hypertrophy                                                                                                      10 (100%)    
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Adrenal Cortex                                     (10)         (10)         (10)         (10)         (10)         (10)         
      Hemorrhage                                                                                                        1 (10%)     
      Zona Fasciculata, Vacuolization Cytoplasmic                                                          1 (10%)      4 (40%)     
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Clitoral Gland                                     (10)                                                             (10)         
      Inflammation, Chronic                            1 (10%)                                                                      
   Ovary                                              (10)         (10)         (10)         (10)         (10)         (10)         
      Atrophy                                                                                                          10 (100%)    
      Cyst                                                                                    1 (10%)      1 (10%)                  
a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                  INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:02:40  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      1.0          3.0          10.0         30.0         100.0           
                                                                MG/M3        MG/M3        MG/M3        MG/M3        MG/M3           
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT                                                                                                               
      Periovarian Tissue, Cyst                                                   1 (10%)                                            
   Uterus                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Atrophy                                                                                                          10 (100%)    
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Bone Marrow                                        (10)         (10)         (10)         (10)         (10)         (10)         
      Hyperplasia                                                                                          3 (30%)     10 (100%)    
      Inflammation, Granulomatous                      2 (20%)      1 (10%)      1 (10%)      1 (10%)                               
   Lymph Node, Bronchial                              (7)          (9)          (10)         (10)         (10)         (9)          
      Hyperplasia                                                   7 (78%)      7 (70%)      9 (90%)     10 (100%)     5 (56%)     
      Pigmentation                                                  8 (89%)     10 (100%)     9 (90%)     10 (100%)     9 (100%)    
   Lymph Node, Mandibular                             (9)                                                 (9)          (9)          
      Atrophy                                                                                                           5 (56%)     
   Lymph Node, Mesenteric                             (10)         (9)          (10)         (10)         (10)         (9)          
      Inflammation, Granulomatous                                                             1 (10%)                               
   Lymph Node, Mediastinal                            (7)          (9)          (8)          (5)          (9)          (8)          
      Atrophy                                                                                                           1 (13%)     
      Hyperplasia                                                   8 (89%)      8 (100%)     4 (80%)      5 (56%)      7 (88%)     
      Pigmentation                                                  8 (89%)      8 (100%)     5 (100%)     7 (78%)      8 (100%)    
   Spleen                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Hematopoietic Cell Proliferation                                                                                  9 (90%)     
   Thymus                                             (10)         (10)         (10)         (10)         (10)         (9)          
      Atrophy                                                                                                           9 (100%)    
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                  INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:02:40  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      1.0          3.0          10.0         30.0         100.0           
                                                                MG/M3        MG/M3        MG/M3        MG/M3        MG/M3           
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Larynx                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Foreign Body                                                 10 (100%)    10 (100%)    10 (100%)     9 (90%)      9 (90%)     
      Hyperplasia                                                                                                       1 (10%)     
      Inflammation, Acute                                                                                               1 (10%)     
      Inflammation, Chronic                                         2 (20%)      6 (60%)      9 (90%)      9 (90%)                  
   Lung                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Foreign Body                                                  9 (90%)     10 (100%)    10 (100%)    10 (100%)    10 (100%)    
      Inflammation, Chronic Active                                 10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)    
      Alveolar Epithelium, Hyperplasia                             10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)    
      Alveolus, Infiltration Cellular, Histiocyte      3 (30%)                                                                      
      Alveolus, Proteinosis                                        10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)    
      Interstitium, Fibrosis                                                    10 (100%)    10 (100%)    10 (100%)    10 (100%)    
   Nose                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Foreign Body                                                  3 (30%)      2 (20%)      7 (70%)      9 (90%)     10 (100%)    
      Inflammation, Chronic                                         1 (10%)                   1 (10%)      3 (30%)                  
      Nasolacrimal Duct, Inflammation, Acute                                                  1 (10%)                               
   Trachea                                            (10)         (10)         (10)         (10)         (10)         (10)         
      Foreign Body                                                                            3 (30%)      7 (70%)      7 (70%)     
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Mineralization                                  10 (100%)     8 (80%)      9 (90%)      9 (90%)      8 (80%)      7 (70%)     
      Nephropathy                                      1 (10%)                                1 (10%)      1 (10%)     10 (100%)    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                  INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:02:40  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      1.0          3.0          10.0         30.0         100.0           
                                                                MG/M3        MG/M3        MG/M3        MG/M3        MG/M3           
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Natural Death                                                                                                       1           
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10            9           
  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Liver                                              (10)         (1)          (1)          (1)                       (10)         
      Eosinophilic Focus                                                                                                1 (10%)     
      Hematopoietic Cell Proliferation                                                                                  1 (10%)     
      Hepatodiaphragmatic Nodule                       1 (10%)      1 (100%)     1 (100%)     1 (100%)                  4 (40%)     
      Infiltration Cellular, Mononuclear Cell                                                                           1 (10%)     
      Pigmentation, Hemosiderin                                                                                         2 (20%)     
      Bile Duct, Hyperplasia                                                                                            2 (20%)     
      Hepatocyte, Centrilobular, Atrophy                                                                                6 (60%)     
      Hepatocyte, Centrilobular, Necrosis                                                                               5 (50%)     
   Mesentery                                                                                 (1)          (1)                       
      Fat, Necrosis                                                                           1 (100%)     1 (100%)                 
   Pancreas                                           (10)                                                             (10)         
      Acinus, Atrophy                                                                                                   1 (10%)     
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (10)         (10)         (10)         (10)         (10)         (10)         
      Cardiomyopathy                                   6 (60%)      7 (70%)      6 (60%)      3 (30%)      5 (50%)      2 (20%)     
      Hypertrophy                                                                                                       8 (80%)     
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Adrenal Cortex                                     (10)         (10)         (10)         (10)         (10)         (10)         
      Zona Fasciculata, Vacuolization Cytoplasmic                                                                      10 (100%)    
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                  INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:02:40  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      1.0          3.0          10.0         30.0         100.0           
                                                                MG/M3        MG/M3        MG/M3        MG/M3        MG/M3           
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Epididymis                                         (10)         (10)         (10)         (10)         (10)         (10)         
      Degeneration                                                                                                     10 (100%)    
   Prostate                                           (10)         (10)         (10)         (10)         (10)         (10)         
      Atrophy                                                                                                          10 (100%)    
   Seminal Vesicle                                    (10)         (10)         (10)         (10)         (10)         (9)          
      Atrophy                                                                                                           9 (100%)    
   Testes                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Mineralization                                                             1 (10%)                                            
      Germinal Epithelium, Degeneration                                                                                 5 (50%)     
      Sertoli Cell, Degeneration                                                 1 (10%)                                            
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Bone Marrow                                        (10)         (10)         (10)         (10)         (10)         (10)         
      Hyperplasia                                                                                                      10 (100%)    
   Lymph Node, Bronchial                              (9)          (10)         (8)          (10)         (10)         (9)          
      Hyperplasia                                                   5 (50%)      4 (50%)      3 (30%)      6 (60%)      3 (33%)     
      Pigmentation                                                  9 (90%)      8 (100%)    10 (100%)    10 (100%)     9 (100%)    
   Lymph Node, Mandibular                             (10)                                                (8)          (10)         
      Atrophy                                                                                                           6 (60%)     
   Lymph Node, Mediastinal                            (9)          (5)          (8)          (10)         (8)          (10)         
      Hyperplasia                                                   3 (60%)      7 (88%)      8 (80%)      6 (75%)      8 (80%)     
      Pigmentation                                                  4 (80%)      8 (100%)     9 (90%)      7 (88%)      9 (90%)     
   Spleen                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Hematopoietic Cell Proliferation                                                                                 10 (100%)    
   Thymus                                             (10)         (10)         (10)         (10)         (10)         (9)          
      Atrophy                                                                                                           8 (89%)     
      Hemorrhage                                       1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   Skin                                               (10)         (1)                                                 (10)         
      Ulcer                                                         1 (100%)                                                        
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                  INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:02:40  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      1.0          3.0          10.0         30.0         100.0           
                                                                MG/M3        MG/M3        MG/M3        MG/M3        MG/M3           
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Larynx                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Foreign Body                                                 10 (100%)    10 (100%)    10 (100%)    10 (100%)     9 (90%)     
      Inflammation, Chronic                                                      5 (50%)      8 (80%)      9 (90%)                  
   Lung                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Foreign Body                                                 10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)    
      Inflammation, Chronic Active                                 10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)    
      Alveolar Epithelium, Hyperplasia                             10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)    
      Alveolus, Infiltration Cellular, Histiocyte      4 (40%)                                                                      
      Alveolus, Proteinosis                                        10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)    
      Interstitium, Fibrosis                                                    10 (100%)    10 (100%)     9 (90%)     10 (100%)    
      Serosa, Hemorrhage                               1 (10%)                                                                      
   Nose                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Foreign Body                                                  1 (10%)      1 (10%)      8 (80%)      8 (80%)     10 (100%)    
   Trachea                                            (10)         (10)         (10)         (10)         (10)         (10)         
      Foreign Body                                                               1 (10%)      2 (20%)      5 (50%)      8 (80%)     
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Nephropathy                                      7 (70%)      4 (40%)      5 (50%)      1 (10%)      4 (40%)     10 (100%)    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
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