TDMS Study 88124-02 Pathology Tables
NTP Experiment-Test: 88124-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:05:30 FINAL#2, 13 WEEK SUBCHRONIC Facility: Battelle Northwest Chemical CAS #: 22398-80-7 Lock Date: 01/24/96 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 88124-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:05:30 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 1.0 3.0 10.0 30.0 100.0 MG/M3 MG/M3 MG/M3 MG/M3 MG/M3 ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 10 10 10 10 10 10 Early Deaths Accidently Killed 1 Natural Death 2 Moribund Sacrifice 1 10 Survivors Terminal Sacrifice 10 10 10 10 6 Animals Examined Microscopically 10 10 10 10 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (10) (10) (10) Inflammation, Focal 3 (30%) Salivary Glands (10) (10) (10) (10) (10) (10) Degeneration 3 (30%) 9 (90%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (10) (10) (10) (10) (10) (10) Cardiomyopathy 1 (10%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (10) (10) (10) (10) (10) (10) Degeneration 8 (80%) 10 (100%) Thyroid Gland (10) (10) (9) Inflammation 1 (10%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (9) (10) (10) (10) (10) (10) Atrophy 9 (90%) 9 (90%) Cyst 1 (10%) Uterus (10) (10) (10) (10) (10) (10) Atrophy 4 (40%) 8 (80%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88124-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:05:30 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 1.0 3.0 10.0 30.0 100.0 MG/M3 MG/M3 MG/M3 MG/M3 MG/M3 ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node, Bronchial (9) (10) (10) (10) (8) (10) Hyperplasia 10 (100%) 10 (100%) 10 (100%) 6 (75%) 8 (80%) Pigmentation 10 (100%) 10 (100%) 10 (100%) 8 (100%) 9 (90%) Lymph Node, Mesenteric (10) (9) (9) Hyperplasia 1 (11%) Lymph Node, Mediastinal (2) (3) (1) (4) (6) Hyperplasia 1 (50%) 1 (33%) 3 (75%) 1 (17%) Pigmentation 3 (75%) 3 (50%) Spleen (10) (10) (10) (10) (9) (10) Hematopoietic Cell Proliferation 1 (10%) 3 (30%) 3 (30%) 6 (67%) 5 (50%) Thymus (10) (10) (10) (10) (9) (9) Atrophy 3 (33%) 9 (100%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (10) (10) (10) (10) (10) (10) Fat, Atrophy 3 (30%) 10 (100%) Skin (10) (1) (10) (10) Subcutaneous Tissue, Hemorrhage 1 (10%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (10) (10) (10) Hemorrhage 1 (10%) Necrosis, Focal 1 (10%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Larynx (10) (10) (10) (10) (10) (10) Foreign Body 1 (10%) 5 (50%) 4 (40%) 6 (60%) Inflammation, Suppurative 1 (10%) 1 (10%) 6 (60%) Necrosis 1 (10%) 3 (30%) 5 (50%) Epiglottis, Metaplasia, Squamous 4 (40%) 5 (50%) 5 (50%) Squamous Epithelium, Hyperplasia 1 (10%) 4 (40%) 7 (70%) 10 (100%) Lung (10) (10) (10) (10) (10) (10) Foreign Body 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%) Inflammation, Chronic Active 10 (100%) 10 (100%) 10 (100%) 9 (90%) 10 (100%) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88124-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:05:30 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 1.0 3.0 10.0 30.0 100.0 MG/M3 MG/M3 MG/M3 MG/M3 MG/M3 ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - CONT Alveolar Epithelium, Hyperplasia 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%) Alveolus, Proteinosis 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%) Interstitium, Fibrosis 10 (100%) 10 (100%) 10 (100%) 9 (90%) 10 (100%) Nose (10) (10) (10) (10) (10) (10) Foreign Body 2 (20%) 3 (30%) 10 (100%) Trachea (10) (10) (9) (10) (10) (10) Foreign Body 1 (11%) 6 (60%) 1 (10%) 5 (50%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (10) (10) (10) Infarct 1 (10%) Nephropathy 1 (10%) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88124-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:05:30 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 1.0 3.0 10.0 30.0 100.0 MG/M3 MG/M3 MG/M3 MG/M3 MG/M3 ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 10 10 10 10 10 10 Early Deaths Moribund Sacrifice 1 9 Natural Death 1 Survivors Terminal Sacrifice 10 10 10 10 9 Animals Examined Microscopically 10 10 10 10 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (10) (1) (10) (10) Inflammation, Focal 1 (10%) Necrosis, Focal 1 (10%) 1 (100%) 1 (10%) Stomach, Forestomach (10) (10) (10) Ulcer 1 (10%) Epithelium, Hyperplasia 1 (10%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (10) (10) (10) (10) (10) (10) Cardiomyopathy 1 (10%) 1 (10%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (10) (10) (10) Hypertrophy 1 (10%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Penis (1) (2) Congestion 1 (50%) Inflammation 1 (100%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88124-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:05:30 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 1.0 3.0 10.0 30.0 100.0 MG/M3 MG/M3 MG/M3 MG/M3 MG/M3 ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (10) (10) (10) (10) (10) (10) Hyperplasia 2 (20%) Lymph Node, Bronchial (8) (10) (10) (10) (10) (7) Hyperplasia 10 (100%) 10 (100%) 10 (100%) 8 (80%) 7 (100%) Pigmentation 10 (100%) 10 (100%) 10 (100%) 10 (100%) 7 (100%) Lymph Node, Mediastinal (4) (6) (1) (3) (5) (6) Hyperplasia 1 (17%) 1 (33%) 2 (40%) 3 (50%) Pigmentation 2 (33%) 1 (33%) 2 (40%) 4 (67%) Spleen (10) (10) (10) (9) (9) (10) Hematopoietic Cell Proliferation 5 (50%) 3 (30%) 3 (33%) 6 (67%) 9 (90%) Thymus (10) (9) (10) (10) (7) (7) Atrophy 1 (14%) 7 (100%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Larynx (10) (10) (10) (10) (10) (10) Foreign Body 2 (20%) 2 (20%) 6 (60%) 6 (60%) 4 (40%) Inflammation, Suppurative 1 (10%) 3 (30%) 1 (10%) 5 (50%) 4 (40%) Necrosis 2 (20%) 4 (40%) 1 (10%) 2 (20%) 3 (30%) 4 (40%) Epiglottis, Metaplasia, Squamous 1 (10%) 9 (90%) 8 (80%) 9 (90%) Respiratory Epithelium, Degeneration, Hyaline 1 (10%) Squamous Epithelium, Hyperplasia 3 (30%) 9 (90%) 8 (80%) Lung (10) (10) (10) (10) (10) (10) Foreign Body 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%) Inflammation, Chronic Active 10 (100%) 10 (100%) 10 (100%) 9 (90%) 10 (100%) Alveolar Epithelium, Hyperplasia 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%) Alveolus, Proteinosis 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%) Interstitium, Fibrosis 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%) Nose (10) (10) (10) (10) (10) (10) Foreign Body 2 (20%) 1 (10%) 9 (90%) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88124-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:05:30 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 1.0 3.0 10.0 30.0 100.0 MG/M3 MG/M3 MG/M3 MG/M3 MG/M3 ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - CONT Inflammation 1 (10%) Inflammation, Suppurative 1 (10%) Trachea (10) (10) (10) (10) (10) (10) Foreign Body 2 (20%) 3 (30%) 3 (30%) 3 (30%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (10) (1) (10) (10) Infarct 1 (10%) Nephropathy 2 (20%) 1 (10%) Urinary Bladder (10) (10) (10) Inflammation, Chronic 1 (10%) a Number of animals examined microscopically at site and number of animals with lesion ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------ --multipart-boundary Content-type: text/plain Range: bytes 38765-38765/38765 --multipart-boundary--