TDMS Study 88124-02 Pathology Tables
NTP Experiment-Test: 88124-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:05:30
FINAL#2, 13 WEEK SUBCHRONIC
Facility: Battelle Northwest
Chemical CAS #: 22398-80-7
Lock Date: 01/24/96
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 88124-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:05:30
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 1.0 3.0 10.0 30.0 100.0
MG/M3 MG/M3 MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Accidently Killed 1
Natural Death 2
Moribund Sacrifice 1 10
Survivors
Terminal Sacrifice 10 10 10 10 6
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10)
Inflammation, Focal 3 (30%)
Salivary Glands (10) (10) (10) (10) (10) (10)
Degeneration 3 (30%) 9 (90%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (10) (10) (10) (10) (10)
Cardiomyopathy 1 (10%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10) (10) (10)
Degeneration 8 (80%) 10 (100%)
Thyroid Gland (10) (10) (9)
Inflammation 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (9) (10) (10) (10) (10) (10)
Atrophy 9 (90%) 9 (90%)
Cyst 1 (10%)
Uterus (10) (10) (10) (10) (10) (10)
Atrophy 4 (40%) 8 (80%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88124-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:05:30
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 1.0 3.0 10.0 30.0 100.0
MG/M3 MG/M3 MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Bronchial (9) (10) (10) (10) (8) (10)
Hyperplasia 10 (100%) 10 (100%) 10 (100%) 6 (75%) 8 (80%)
Pigmentation 10 (100%) 10 (100%) 10 (100%) 8 (100%) 9 (90%)
Lymph Node, Mesenteric (10) (9) (9)
Hyperplasia 1 (11%)
Lymph Node, Mediastinal (2) (3) (1) (4) (6)
Hyperplasia 1 (50%) 1 (33%) 3 (75%) 1 (17%)
Pigmentation 3 (75%) 3 (50%)
Spleen (10) (10) (10) (10) (9) (10)
Hematopoietic Cell Proliferation 1 (10%) 3 (30%) 3 (30%) 6 (67%) 5 (50%)
Thymus (10) (10) (10) (10) (9) (9)
Atrophy 3 (33%) 9 (100%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (10) (10) (10) (10) (10) (10)
Fat, Atrophy 3 (30%) 10 (100%)
Skin (10) (1) (10) (10)
Subcutaneous Tissue, Hemorrhage 1 (10%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (10) (10) (10)
Hemorrhage 1 (10%)
Necrosis, Focal 1 (10%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (10) (10) (10) (10) (10) (10)
Foreign Body 1 (10%) 5 (50%) 4 (40%) 6 (60%)
Inflammation, Suppurative 1 (10%) 1 (10%) 6 (60%)
Necrosis 1 (10%) 3 (30%) 5 (50%)
Epiglottis, Metaplasia, Squamous 4 (40%) 5 (50%) 5 (50%)
Squamous Epithelium, Hyperplasia 1 (10%) 4 (40%) 7 (70%) 10 (100%)
Lung (10) (10) (10) (10) (10) (10)
Foreign Body 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Inflammation, Chronic Active 10 (100%) 10 (100%) 10 (100%) 9 (90%) 10 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88124-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:05:30
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 1.0 3.0 10.0 30.0 100.0
MG/M3 MG/M3 MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Alveolar Epithelium, Hyperplasia 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Alveolus, Proteinosis 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Interstitium, Fibrosis 10 (100%) 10 (100%) 10 (100%) 9 (90%) 10 (100%)
Nose (10) (10) (10) (10) (10) (10)
Foreign Body 2 (20%) 3 (30%) 10 (100%)
Trachea (10) (10) (9) (10) (10) (10)
Foreign Body 1 (11%) 6 (60%) 1 (10%) 5 (50%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10)
Infarct 1 (10%)
Nephropathy 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88124-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:05:30
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 1.0 3.0 10.0 30.0 100.0
MG/M3 MG/M3 MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Moribund Sacrifice 1 9
Natural Death 1
Survivors
Terminal Sacrifice 10 10 10 10 9
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (1) (10) (10)
Inflammation, Focal 1 (10%)
Necrosis, Focal 1 (10%) 1 (100%) 1 (10%)
Stomach, Forestomach (10) (10) (10)
Ulcer 1 (10%)
Epithelium, Hyperplasia 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (10) (10) (10) (10) (10)
Cardiomyopathy 1 (10%) 1 (10%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10)
Hypertrophy 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Penis (1) (2)
Congestion 1 (50%)
Inflammation 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88124-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:05:30
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 1.0 3.0 10.0 30.0 100.0
MG/M3 MG/M3 MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (10) (10) (10) (10) (10) (10)
Hyperplasia 2 (20%)
Lymph Node, Bronchial (8) (10) (10) (10) (10) (7)
Hyperplasia 10 (100%) 10 (100%) 10 (100%) 8 (80%) 7 (100%)
Pigmentation 10 (100%) 10 (100%) 10 (100%) 10 (100%) 7 (100%)
Lymph Node, Mediastinal (4) (6) (1) (3) (5) (6)
Hyperplasia 1 (17%) 1 (33%) 2 (40%) 3 (50%)
Pigmentation 2 (33%) 1 (33%) 2 (40%) 4 (67%)
Spleen (10) (10) (10) (9) (9) (10)
Hematopoietic Cell Proliferation 5 (50%) 3 (30%) 3 (33%) 6 (67%) 9 (90%)
Thymus (10) (9) (10) (10) (7) (7)
Atrophy 1 (14%) 7 (100%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (10) (10) (10) (10) (10) (10)
Foreign Body 2 (20%) 2 (20%) 6 (60%) 6 (60%) 4 (40%)
Inflammation, Suppurative 1 (10%) 3 (30%) 1 (10%) 5 (50%) 4 (40%)
Necrosis 2 (20%) 4 (40%) 1 (10%) 2 (20%) 3 (30%) 4 (40%)
Epiglottis, Metaplasia, Squamous 1 (10%) 9 (90%) 8 (80%) 9 (90%)
Respiratory Epithelium, Degeneration, Hyaline 1 (10%)
Squamous Epithelium, Hyperplasia 3 (30%) 9 (90%) 8 (80%)
Lung (10) (10) (10) (10) (10) (10)
Foreign Body 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Inflammation, Chronic Active 10 (100%) 10 (100%) 10 (100%) 9 (90%) 10 (100%)
Alveolar Epithelium, Hyperplasia 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Alveolus, Proteinosis 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Interstitium, Fibrosis 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Nose (10) (10) (10) (10) (10) (10)
Foreign Body 2 (20%) 1 (10%) 9 (90%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88124-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:05:30
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 1.0 3.0 10.0 30.0 100.0
MG/M3 MG/M3 MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Inflammation 1 (10%)
Inflammation, Suppurative 1 (10%)
Trachea (10) (10) (10) (10) (10) (10)
Foreign Body 2 (20%) 3 (30%) 3 (30%) 3 (30%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (1) (10) (10)
Infarct 1 (10%)
Nephropathy 2 (20%) 1 (10%)
Urinary Bladder (10) (10) (10)
Inflammation, Chronic 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
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