TDMS Study 88124-02 Pathology Tables
NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54 FINAL#2, 13 WEEK SUBCHRONIC Facility: Battelle Northwest Chemical CAS #: 22398-80-7 Lock Date: 01/24/96 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Inflammation, Focal | 1 1 1 | 3 1.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Parathyroid Gland | M + + + M M M M M + | 4 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | Inflammation | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + M + + + | 9 | __________________________________________________________________________|____________| Ovary | + + + + + I + + + + | 9 | __________________________________________________________________________|____________| Oviduct | + | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + + M + + | 9 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Mandibular | + M + + + + + + + + | 9 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | M M M M M M M M M M | | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | Hematopoietic Cell Proliferation | 2 | 1 2.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + | 10 | Inflammation, Suppurative | 1 | 1 1.0| Necrosis | 1 | 1 1.0| __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Nephropathy | 1 | 1 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + + + + + | 10 | Hyperplasia | 3 2 2 2 2 3 2 2 3 2 | 10 2.3| Pigmentation | 1 1 1 1 1 1 1 1 1 1 | 10 1.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | M M M + M M + M M M | 2 | Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | Hematopoietic Cell Proliferation | 2 1 2 | 3 1.7| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Skin | + | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Foreign Body | 2 2 3 2 2 2 2 3 2 2 | 10 2.2| Inflammation, Chronic Active | 3 2 3 3 3 2 3 3 2 1 | 10 2.5| Alveolar Epithelium, Hyperplasia | 1 1 2 2 1 1 1 1 2 1 | 10 1.3| Alveolus, Proteinosis | 3 4 4 4 3 3 3 3 3 4 | 10 3.4| Interstitium, Fibrosis | 1 1 1 1 1 1 1 1 1 1 | 10 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 3.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Vagina | + | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + + + + + | 10 | Hyperplasia | 3 3 2 2 2 2 3 2 2 2 | 10 2.3| Pigmentation | 1 1 2 1 1 1 1 1 1 1 | 10 1.1| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + M + M M M M + M M | 3 | Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | Hematopoietic Cell Proliferation | 2 1 1 | 3 1.3| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + | 10 | Foreign Body | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 3.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Squamous Epithelium, Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Foreign Body | 3 3 3 3 3 3 3 3 3 3 | 10 3.0| Inflammation, Chronic Active | 3 2 2 2 1 2 3 2 3 2 | 10 2.2| Alveolar Epithelium, Hyperplasia | 2 2 2 2 1 1 1 1 2 2 | 10 1.6| Alveolus, Proteinosis | 4 3 3 4 3 3 4 4 3 4 | 10 3.5| Interstitium, Fibrosis | 2 1 1 1 1 2 1 1 2 2 | 10 1.4| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Trachea | + + + I + + + + + + | 9 | Foreign Body | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Zymbal's Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A | 10.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + + + + + | 10 | Hyperplasia | 2 2 2 2 2 2 1 2 3 2 | 10 2.0| Pigmentation | 2 1 2 1 1 1 1 1 1 1 | 10 1.2| __________________________________________________________________________|____________| Lymph Node, Mediastinal | M M M M M M M M M + | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + | 10 | Foreign Body | 2 1 1 1 1 | 5 1.2| Epiglottis, Metaplasia, Squamous | 1 1 1 2 | 4 1.3| Squamous Epithelium, Hyperplasia | 1 1 2 1 | 4 1.3| __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A | 10.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Foreign Body | 3 3 3 3 3 3 3 3 3 3 | 10 3.0| Inflammation, Chronic Active | 3 2 3 4 3 3 3 3 3 3 | 10 3.0| Alveolar Epithelium, Hyperplasia | 2 1 2 2 2 2 1 2 2 2 | 10 1.8| Alveolus, Proteinosis | 4 4 3 4 4 4 4 4 3 4 | 10 3.8| Interstitium, Fibrosis | 3 2 3 3 2 3 3 3 2 3 | 10 2.7| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | Foreign Body | 1 1 | 2 1.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | Foreign Body | 1 1 1 1 1 1 | 6 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 2| 9| 9| 9| 9| 9| 9| 8| 9| 7| | | | 4| 6| 4| 6| 6| 6| 6| 0| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A | 30.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Gallbladder | + + A + + + + M + + | 8 | __________________________________________________________________________|____________| Intestine Large, Colon | + + A + + + + A + + | 8 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + A + + | 9 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + A + + + + A + + | 8 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + A + + + + A + + | 8 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + M + + + + A + + | 8 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + A + + + + A + + | 8 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Pancreas | + + + + + + + A + + | 9 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | Degeneration | 1 1 1 | 3 1.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + A + + | 9 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + A + + | 9 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | Degeneration | 2 2 2 2 2 2 2 2 | 8 2.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + M + + + | 9 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + A + + | 9 | __________________________________________________________________________|____________| Parathyroid Gland | + + M M M M + + + + | 6 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + M | 9 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | Atrophy | 2 2 2 2 2 2 2 2 2 | 9 2.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | Atrophy | 2 1 2 1 | 4 1.5| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 2| 9| 9| 9| 9| 9| 9| 8| 9| 7| | | | 4| 6| 4| 6| 6| 6| 6| 0| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A | 30.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + M + + M + + + + | 8 | Hyperplasia | 1 3 2 2 3 3 | 6 2.3| Pigmentation | 1 2 2 2 3 2 2 2 | 8 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | M + M + + M + M + + | 6 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + M + + | 9 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + M + M M M M + M + | 4 | Hyperplasia | 3 2 2 | 3 2.3| Pigmentation | 2 2 2 | 3 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + A + + | 9 | Hematopoietic Cell Proliferation | 1 1 1 2 2 1 | 6 1.3| __________________________________________________________________________|____________| Thymus | + + M + + + + + + + | 9 | Atrophy | 1 4 1 | 3 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 10 | Fat, Atrophy | 4 2 4 | 3 3.3| __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | Subcutaneous Tissue, Hemorrhage | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | Hemorrhage | 2 | 1 2.0| Necrosis, Focal | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + | 10 | Foreign Body | 1 2 2 1 | 4 1.5| Inflammation, Suppurative | 1 | 1 1.0| Necrosis | 1 1 1 | 3 1.0| Epiglottis, Metaplasia, Squamous | 2 1 1 1 1 | 5 1.2| Squamous Epithelium, Hyperplasia | 3 2 2 2 3 2 2 | 7 2.3| __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Foreign Body | 4 4 4 4 4 4 4 3 4 4 | 10 3.9| Inflammation, Chronic Active | 2 3 2 3 3 3 3 2 3 | 9 2.7| Alveolar Epithelium, Hyperplasia | 1 3 4 3 4 4 3 2 3 4 | 10 3.1| Alveolus, Proteinosis | 3 3 4 4 4 4 4 4 3 4 | 10 3.7| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 2| 9| 9| 9| 9| 9| 9| 8| 9| 7| | | | 4| 6| 4| 6| 6| 6| 6| 0| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A | 30.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Interstitium, Fibrosis | 4 4 4 4 4 4 4 4 4 | 9 4.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | Foreign Body | 2 1 1 | 3 1.3| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | Foreign Body | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Infarct | 2 | 1 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + A + + | 9 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 5| 6| 5| 6| 6| 5| 6| 5| 6| 5| | | | 7| 3| 7| 0| 2| 9| 1| 8| 0| 7| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 100.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | Degeneration | 1 2 2 1 1 2 1 1 2 | 9 1.4| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | Cardiomyopathy | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | Degeneration | 2 2 2 2 2 2 2 2 2 2 | 10 2.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Parathyroid Gland | M M M M M + + M + + | 4 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + M + + | 9 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + M + + + M + + M + | 7 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | Atrophy | 2 2 2 2 2 2 2 2 2 | 9 2.0| Cyst | 1 | 1 1.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | Atrophy | 2 3 3 2 2 3 2 2 | 8 2.4| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 5| 6| 5| 6| 6| 5| 6| 5| 6| 5| | | | 7| 3| 7| 0| 2| 9| 1| 8| 0| 7| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 100.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + + + + + | 10 | Hyperplasia | 2 2 2 2 2 3 2 3 | 8 2.3| Pigmentation | 3 2 3 2 2 1 3 2 3 | 9 2.3| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + M + + + + + + | 9 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + M | 9 | Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | M + + M M + M + + + | 6 | Hyperplasia | 2 | 1 2.0| Pigmentation | 2 1 2 | 3 1.7| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | Hematopoietic Cell Proliferation | 1 1 1 2 1 | 5 1.2| __________________________________________________________________________|____________| Thymus | + + + + + M + + + + | 9 | Atrophy | 3 3 2 3 2 4 3 3 4 | 9 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 10 | Fat, Atrophy | 4 3 3 4 3 4 4 4 3 4 | 10 3.6| __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + | 10 | Foreign Body | 1 2 1 1 1 1 | 6 1.2| Inflammation, Suppurative | 1 1 1 1 2 1 | 6 1.2| Necrosis | 1 1 1 1 2 | 5 1.2| Epiglottis, Metaplasia, Squamous | 1 2 1 2 2 | 5 1.6| Squamous Epithelium, Hyperplasia | 1 2 3 3 3 3 2 1 3 3 | 10 2.4| __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Foreign Body | 4 4 4 4 4 4 4 4 4 4 | 10 4.0| Inflammation, Chronic Active | 3 3 3 3 3 3 3 3 3 3 | 10 3.0| Alveolar Epithelium, Hyperplasia | 4 4 4 4 4 4 4 4 4 4 | 10 4.0| Alveolus, Proteinosis | 4 4 4 4 4 4 4 4 4 4 | 10 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 5| 6| 5| 6| 6| 5| 6| 5| 6| 5| | | | 7| 3| 7| 0| 2| 9| 1| 8| 0| 7| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 100.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Interstitium, Fibrosis | 4 4 4 4 4 4 4 4 4 4 | 10 4.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | Foreign Body | 2 2 1 1 2 1 2 1 2 1 | 10 1.5| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | Foreign Body | 1 1 1 1 2 | 5 1.2| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Necrosis, Focal | 1 | 1 1.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | Hypertrophy | 1 | 1 1.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Parathyroid Gland | + + + M + + M + M + | 7 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Testes | + + + + + + M + + + | 9 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + M M + + + | 8 | __________________________________________________________________________|____________| Lymph Node, Mandibular | M + M M + + + + + + | 7 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | M + M M + M M M + + | 4 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + | 10 | Inflammation, Suppurative | 1 | 1 1.0| Necrosis | 1 1 | 2 1.0| Epiglottis, Metaplasia, Squamous | 1 | 1 1.0| Respiratory Epithelium, Degeneration,| | | Hyaline | 1 | 1 1.0| __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Nephropathy | 1 1 | 2 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | Inflammation, Chronic | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + + + + + | 10 | Hyperplasia | 3 3 3 2 3 3 3 2 2 2 | 10 2.6| Pigmentation | 1 1 1 1 1 1 1 1 1 1 | 10 1.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + M + + M M M | 6 | Hyperplasia | 2 | 1 2.0| Pigmentation | 1 1 | 2 1.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | Hematopoietic Cell Proliferation | 1 1 1 2 1 | 5 1.2| __________________________________________________________________________|____________| Thymus | + + + + + + + I + + | 9 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + | 10 | Foreign Body | 1 1 | 2 1.0| Inflammation, Suppurative | 1 1 1 | 3 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Necrosis | 1 1 1 1 | 4 1.0| __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Foreign Body | 2 3 2 3 2 2 2 3 2 3 | 10 2.4| Inflammation, Chronic Active | 3 3 3 3 2 3 2 3 2 3 | 10 2.7| Alveolar Epithelium, Hyperplasia | 2 2 1 1 2 1 1 1 1 1 | 10 1.3| Alveolus, Proteinosis | 4 3 4 4 4 4 3 4 3 3 | 10 3.6| Interstitium, Fibrosis | 1 1 1 1 1 1 1 1 1 1 | 10 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 3.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + + + + + | 10 | Hyperplasia | 3 2 2 2 2 2 2 2 2 2 | 10 2.1| Pigmentation | 1 1 1 1 1 1 2 1 1 1 | 10 1.1| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + M M M M M M M M M | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | Hematopoietic Cell Proliferation | 1 1 1 | 3 1.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + | 10 | Foreign Body | 1 1 | 2 1.0| Necrosis | 1 | 1 1.0| __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Foreign Body | 3 3 3 3 3 3 3 3 3 3 | 10 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 3.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Inflammation, Chronic Active | 3 2 3 2 3 2 2 3 3 3 | 10 2.6| Alveolar Epithelium, Hyperplasia | 2 2 1 1 1 1 1 2 1 2 | 10 1.4| Alveolus, Proteinosis | 4 4 4 4 4 4 4 4 4 4 | 10 4.0| Interstitium, Fibrosis | 2 2 1 1 1 1 1 2 2 3 | 10 1.6| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | Inflammation, Suppurative | 1 | 1 1.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | Foreign Body | 1 1 | 2 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A | 10.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Liver | + | 1 | Necrosis, Focal | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + + + + + | 10 | Hyperplasia | 1 2 2 3 2 2 2 3 3 2 | 10 2.2| Pigmentation | 1 1 1 1 2 2 2 1 1 1 | 10 1.3| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + M + M + M M M M M | 3 | Hyperplasia | 3 | 1 3.0| Pigmentation | 1 | 1 1.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + I + | 9 | Hematopoietic Cell Proliferation | 1 1 2 | 3 1.3| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + | 10 | Foreign Body | 1 1 2 1 1 1 | 6 1.2| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A | 10.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Inflammation, Suppurative | 1 | 1 1.0| Necrosis | 1 1 | 2 1.0| Epiglottis, Metaplasia, Squamous | 1 1 1 1 1 1 1 1 1 | 9 1.0| Squamous Epithelium, Hyperplasia | 1 2 1 | 3 1.3| __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Foreign Body | 3 4 3 4 4 4 3 3 3 3 | 10 3.4| Inflammation, Chronic Active | 3 3 3 2 2 2 2 3 2 3 | 10 2.5| Alveolar Epithelium, Hyperplasia | 4 3 3 4 4 3 3 3 2 2 | 10 3.1| Alveolus, Proteinosis | 4 4 4 4 4 4 4 4 4 4 | 10 4.0| Interstitium, Fibrosis | 4 3 4 3 4 2 3 3 2 3 | 10 3.1| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | Foreign Body | 1 1 | 2 1.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | Foreign Body | 1 1 1 | 3 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 6| 1| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A | 30.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Gallbladder | + + M + + + + + + + | 9 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Necrosis, Focal | 1 | 1 1.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | Cardiomyopathy | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Parathyroid Gland | M + M + + M M M + M | 4 | __________________________________________________________________________|____________| Pituitary Gland | M + + + + + + + + + | 9 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Penis | + | 1 | Inflammation | 2 | 1 2.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 6| 1| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A | 30.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + + + + + | 10 | Hyperplasia | 3 2 1 2 2 3 2 2 | 8 2.1| Pigmentation | 2 2 1 2 1 2 2 2 2 2 | 10 1.8| __________________________________________________________________________|____________| Lymph Node, Mandibular | M M + + + + + M + + | 7 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + M + + + M + + + + | 8 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + M M + + + M M + M | 5 | Hyperplasia | 2 3 | 2 2.5| Pigmentation | 2 3 | 2 2.5| __________________________________________________________________________|____________| Spleen | + + M + + + + + + + | 9 | Hematopoietic Cell Proliferation | 3 1 1 1 2 2 | 6 1.7| __________________________________________________________________________|____________| Thymus | + M M M + + + + + + | 7 | Atrophy | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + | 10 | Foreign Body | 1 1 1 1 1 2 | 6 1.2| Inflammation, Suppurative | 1 1 1 1 1 | 5 1.0| Necrosis | 1 1 1 | 3 1.0| Epiglottis, Metaplasia, Squamous | 1 1 1 1 1 1 1 1 | 8 1.0| Squamous Epithelium, Hyperplasia | 2 2 3 3 3 2 1 1 2 | 9 2.1| __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Foreign Body | 4 4 4 4 4 4 4 4 4 4 | 10 4.0| Inflammation, Chronic Active | 3 3 3 3 3 3 3 3 3 | 9 3.0| Alveolar Epithelium, Hyperplasia | 4 4 4 4 4 4 4 4 3 4 | 10 3.9| Alveolus, Proteinosis | 4 4 4 4 4 4 4 4 4 4 | 10 4.0| Interstitium, Fibrosis | 4 4 4 4 3 4 4 4 4 4 | 10 3.9| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 6| 1| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A | 30.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Foreign Body | 1 | 1 1.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | Foreign Body | 1 1 1 | 3 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 4| 5| 7| 4| 6| 5| 6| 6| 5| 5| | | | 7| 6| 3| 7| 1| 3| 0| 3| 1| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 100.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Gallbladder | + + + + + + I + A + | 8 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + A + | 9 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + A + | 9 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + A + | 9 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Inflammation, Focal | 1 | 1 1.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | Ulcer | 1 | 1 1.0| Epithelium, Hyperplasia | 3 | 1 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | Cardiomyopathy | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Islets, Pancreatic | + + M + + + + + + + | 9 | __________________________________________________________________________|____________| Parathyroid Gland | M M + + M M M + + M | 4 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Penis | + + | 2 | Congestion | 1 | 1 1.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 4| 5| 7| 4| 6| 5| 6| 6| 5| 5| | | | 7| 6| 3| 7| 1| 3| 0| 3| 1| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 100.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | Hyperplasia | 1 1 | 2 1.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | M + + + M + + + M + | 7 | Hyperplasia | 2 2 2 2 1 2 2 | 7 1.9| Pigmentation | 3 3 2 2 2 2 3 | 7 2.4| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + M M + + M + | 7 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | M + + + + + + + + + | 9 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + M + + + M M M + + | 6 | Hyperplasia | 2 1 2 | 3 1.7| Pigmentation | 3 2 2 2 | 4 2.3| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | Hematopoietic Cell Proliferation | 2 2 3 1 2 2 2 1 2 | 9 1.9| __________________________________________________________________________|____________| Thymus | + M M + + M + + + + | 7 | Atrophy | 1 1 3 3 3 3 3 | 7 2.4| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + | 10 | Foreign Body | 3 1 2 1 | 4 1.8| Inflammation, Suppurative | 1 1 1 1 | 4 1.0| Necrosis | 1 1 1 1 | 4 1.0| Epiglottis, Metaplasia, Squamous | 1 1 2 2 2 2 2 1 2 | 9 1.7| Squamous Epithelium, Hyperplasia | 2 3 2 3 3 2 2 2 | 8 2.4| __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Foreign Body | 4 4 4 4 4 4 4 4 4 4 | 10 4.0| Inflammation, Chronic Active | 3 3 3 3 3 3 3 3 3 3 | 10 3.0| Alveolar Epithelium, Hyperplasia | 4 3 4 4 4 3 4 3 3 4 | 10 3.6| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 4| 5| 7| 4| 6| 5| 6| 6| 5| 5| | | | 7| 6| 3| 7| 1| 3| 0| 3| 1| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 100.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Alveolus, Proteinosis | 4 4 4 4 4 4 4 4 4 4 | 10 4.0| Interstitium, Fibrosis | 3 4 4 4 4 4 4 3 3 4 | 10 3.7| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | Foreign Body | 2 3 3 2 2 2 2 2 2 | 9 2.2| Inflammation | 1 | 1 1.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | Foreign Body | 3 1 2 | 3 2.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Infarct | 2 | 1 2.0| Nephropathy | 1 | 1 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------ --multipart-boundary Content-type: text/plain Range: bytes 261774-261774/261774 --multipart-boundary--