TDMS Study 88124-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Northwest INDIUM PHOSPHIDE DATE: 10/28/99
EXPERIMENT: 88124 TEST: 03 TIME: 13:55:40
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-25335 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C88124
PATHOLOGIST: GRUMBEIN, S. CAS: 22398-80-7
------------------------------------------------------------------------------------------------------------------------------------
14 WEEK SSAC
REASONS FOR REMOVAL: 25017 Scheduled Sacrifice
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Northwest INDIUM PHOSPHIDE DATE: 10/28/99
EXPERIMENT: 88124 TEST: 03 TIME: 13:55:40
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-25335 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C88124
PATHOLOGIST: GRUMBEIN, S. CAS: 22398-80-7
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF INDIUM PHOSPHIDE
===============================================================
Male Rats
------------
Organ Morphology
----- ----------
Lung Foreign Body
Inflammation Chronic
Lung: Alveolar Epithelium Hyperplasia
Lung: Alveolus Proteinosis
Lymph Node, Bronchial Foreign Body
Hyperplasia
Lymph Node, Mediastinal Foreign Body
Hyperplasia
===============================================================
Female Rats
------------
Organ Morphology
----- ----------
Liver Hematopoietic Cell Proliferation
Lung Foreign Body
Inflammation Chronic
Lung: Alveolar Epithelium Hyperplasia
Lung: Alveolus Proteinosis
Lymph Node, Bronchial Foreign Body
Hyperplasia
Lymph Node, Mediastinal Foreign Body
Hyperplasia
===============================================================
Date: 10/28/99 EXPERIMENT: 88124 TEST: 03 Page 1
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - INDIUM PHOSPHIDE
Terminal Sacrifice at 143 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Heart |
| Cardiomyopathy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 4/10 (40%) 0/0 (0%) 0/0 (0%) 2/10 (20%) |2/10 (20%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|POLY-3 ADJUSTED (b)| 99.9% 0.0% 0.0% 99.7% |99.7% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 4/10 (40%) 0/0 (0%) 0/0 (0%) 2/10 (20%) |2/10 (20%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 91 (I) --- --- 91 (I) |92 (I) --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.263N P=1.000N P=1.000N P=0.317N |P=0.166N P=1.000N P=1.000N P=0.234N |
|POLY 3 | (e) (e) (e) P=0.202N |(e) (e) (e) P=0.067N |
|POLY 1.5 | (e) (e) (e) P=0.205N |(e) (e) (e) P=0.070N |
|POLY 6 | (e) (e) (e) P=0.202N |(e) (e) (e) P=0.067N |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.258N P=1.000 P=1.000 P=0.314N |P=0.160N P=1.000 P=1.000 P=0.237N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Kidney |
| Nephropathy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 3/10 (30%) 0/0 (0%) 0/0 (0%) 3/10 (30%) |1/10 (10%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|POLY-3 ADJUSTED (b)| 99.8% 0.0% 0.0% 99.8% |99.3% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 3/10 (30%) 0/0 (0%) 0/0 (0%) 3/10 (30%) |1/10 (10%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 91 (I) --- --- 91 (I) |92 (I) --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.624 P=1.000N P=1.000N P=0.683 |P=0.369N P=1.000N P=1.000N P=0.500N |
|POLY 3 | (e) (e) (e) P=0.555 |(e) (e) (e) P=0.159N |
|POLY 1.5 | (e) (e) (e) P=0.559 |(e) (e) (e) P=0.167N |
|POLY 6 | (e) (e) (e) P=0.555 |(e) (e) (e) P=0.159N |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.628 P=1.000 P=1.000 P=0.686N |P=0.366N P=1.000 P=1.000 P=0.500N |
|=================================================================================================================================|
Date: 10/28/99 EXPERIMENT: 88124 TEST: 03 Page 2
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - INDIUM PHOSPHIDE
Terminal Sacrifice at 143 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Larynx |
| Inflammation Acute |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/10 (0%) 2/10 (20%) 0/10 (0%) 0/10 (0%) |0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 99.7% 0.0% 0.0% |0.0% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 2/10 (20%) 0/10 (0%) 0/10 (0%) |0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 91 (I) --- --- |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.368N P=0.234 (e) (e) |(e) (e) (e) (e) |
|POLY 3 | P=0.160N P=0.067 (e) (e) |(e) (e) (e) (e) |
|POLY 1.5 | P=0.164N P=0.070 (e) (e) |(e) (e) (e) (e) |
|POLY 6 | P=0.160N P=0.067 (e) (e) |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.366N P=0.237 (e) (e) |(e) (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Liver |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/10 (0%) 0/2 (0%) 0/0 (0%) 0/10 (0%) |0/10 (0%) 0/3 (0%) 0/2 (0%) 2/10 (20%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |0.0% 0.0% 0.0% 99.7% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/2 (0%) 0/0 (0%) 0/10 (0%) |0/10 (0%) 0/3 (0%) 0/2 (0%) 2/10 (20%) |
|TERMINAL (d) | 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- |--- --- --- 92 (I) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.111 (e) (e) P=0.234 |
|POLY 3 | (e) (e) (e) (e) |P=0.041 * (e) (e) P=0.067 |
|POLY 1.5 | (e) (e) (e) (e) |P=0.042 * (e) (e) P=0.070 |
|POLY 6 | (e) (e) (e) (e) |P=0.041 * (e) (e) P=0.067 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.106 (e) (e) P=0.237 |
|=================================================================================================================================|
Date: 10/28/99 EXPERIMENT: 88124 TEST: 03 Page 3
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - INDIUM PHOSPHIDE
Terminal Sacrifice at 143 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Liver |
| Inflammation Granulomatous |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/10 (0%) 0/2 (0%) 0/0 (0%) 0/10 (0%) |2/10 (20%) 0/3 (0%) 0/2 (0%) 3/10 (30%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |99.7% 0.0% 0.0% 99.8% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/2 (0%) 0/0 (0%) 0/10 (0%) |2/10 (20%) 0/3 (0%) 0/2 (0%) 3/10 (30%) |
|TERMINAL (d) | 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- |92 (I) --- --- 92 (I) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.310 P=0.527N P=0.630N P=0.500 |
|POLY 3 | (e) (e) (e) (e) |P=0.226 P=0.213N P=0.260N P=0.352 |
|POLY 1.5 | (e) (e) (e) (e) |P=0.225 P=0.220N P=0.268N P=0.356 |
|POLY 6 | (e) (e) (e) (e) |P=0.226 P=0.213N P=0.259N P=0.352 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.306 P=0.577N P=0.682N P=0.500 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Lung |
| Foreign Body |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/10 (0%) 10/10 (100%) 10/10 (100%) 10/10 (100%)|0/10 (0%) 8/10 (80%) 10/10 (100%) 10/10 (100%) |
|POLY-3 ADJUSTED (b)| 0.0% 100.0% 100.0% 100.0% |0.0% 100.0% 100.0% 100.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 10/10 (100%) 10/10 (100%) 10/10 (100%)|0/10 (0%) 8/10 (80%) 10/10 (100%) 10/10 (100%) |
|TERMINAL (d) | 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 91 (I) 91 (I) 91 (I) |--- 92 (I) 92 (I) 92 (I) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 3 | P=1.000N P=1.000N P=1.000N P=1.000N |P<0.001 ** P<0.001 ** P=1.000N P=1.000N |
|POLY 1.5 | P=1.000N P=1.000N P=1.000N P=1.000N |P<0.001 ** P<0.001 ** P=1.000N P=1.000N |
|POLY 6 | P=1.000N P=1.000N P=1.000N P=1.000N |P<0.001 ** P<0.001 ** P=1.000N P=1.000N |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
Date: 10/28/99 EXPERIMENT: 88124 TEST: 03 Page 4
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - INDIUM PHOSPHIDE
Terminal Sacrifice at 143 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Lung |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 1/10 (10%) 10/10 (100%) 10/10 (100%) 10/10 (100%)|2/10 (20%) 10/10 (100%) 10/10 (100%) 10/10 (100%) |
|POLY-3 ADJUSTED (b)| 99.3% 100.0% 100.0% 100.0% |99.7% 100.0% 100.0% 100.0% |
|INT SACRIFICE 1 (c)| 1/10 (10%) 10/10 (100%) 10/10 (100%) 10/10 (100%)|2/10 (20%) 10/10 (100%) 10/10 (100%) 10/10 (100%) |
|TERMINAL (d) | 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 91 (I) 91 (I) 91 (I) 91 (I) |92 (I) 92 (I) 92 (I) 92 (I) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.003 ** P<0.001 ** P<0.001 ** P<0.001 ** |P=0.006 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.002 ** P<0.001 ** P<0.001 ** P<0.001 ** |P=0.005 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Lung: Alveolar Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/10 (0%) 7/10 (70%) 10/10 (100%) 10/10 (100%)|0/10 (0%) 5/10 (50%) 1/10 (10%) 7/10 (70%) |
|POLY-3 ADJUSTED (b)| 0.0% 100.0% 100.0% 100.0% |0.0% 99.9% 99.3% 100.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 7/10 (70%) 10/10 (100%) 10/10 (100%)|0/10 (0%) 5/10 (50%) 1/10 (10%) 7/10 (70%) |
|TERMINAL (d) | 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 91 (I) 91 (I) 91 (I) |--- 92 (I) 92 (I) 92 (I) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001 ** P=0.003 ** P<0.001 ** P<0.001 ** |P=0.008 ** P=0.022 * P=0.500 P=0.003 ** |
|POLY 3 | P<0.001 ** P<0.001 ** P=1.000N P=1.000N |P<0.001 ** P<0.001 ** P=0.159 P<0.001 ** |
|POLY 1.5 | P<0.001 ** P<0.001 ** P=1.000N P=1.000N |P<0.001 ** P<0.001 ** P=0.167 P<0.001 ** |
|POLY 6 | P<0.001 ** P<0.001 ** P=1.000N P=1.000N |P<0.001 ** P<0.001 ** P=0.159 P<0.001 ** |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P<0.001 ** P=0.002 ** P<0.001 ** P<0.001 ** |P=0.007 ** P=0.016 * P=0.500 P=0.002 ** |
|=================================================================================================================================|
Date: 10/28/99 EXPERIMENT: 88124 TEST: 03 Page 5
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - INDIUM PHOSPHIDE
Terminal Sacrifice at 143 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Lung: Alveolus |
| Proteinosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/10 (0%) 10/10 (100%) 10/10 (100%) 10/10 (100%)|0/10 (0%) 9/10 (90%) 10/10 (100%) 10/10 (100%) |
|POLY-3 ADJUSTED (b)| 0.0% 100.0% 100.0% 100.0% |0.0% 100.0% 100.0% 100.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 10/10 (100%) 10/10 (100%) 10/10 (100%)|0/10 (0%) 9/10 (90%) 10/10 (100%) 10/10 (100%) |
|TERMINAL (d) | 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 91 (I) 91 (I) 91 (I) |--- 92 (I) 92 (I) 92 (I) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 3 | P=1.000N P=1.000N P=1.000N P=1.000N |P<0.001 ** P<0.001 ** P=1.000N P=1.000N |
|POLY 1.5 | P=1.000N P=1.000N P=1.000N P=1.000N |P<0.001 ** P<0.001 ** P=1.000N P=1.000N |
|POLY 6 | P=1.000N P=1.000N P=1.000N P=1.000N |P<0.001 ** P<0.001 ** P=1.000N P=1.000N |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Lymph Node, Bronchial |
| Foreign Body |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/10 (0%) 4/6 (67%) 2/10 (20%) 7/9 (78%) |0/4 (0%) 5/8 (63%) 7/8 (88%) 4/6 (67%) |
|POLY-3 ADJUSTED (b)| 0.0% 100.0% 99.7% 100.0% |0.0% 100.0% 100.0% 100.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 4/6 (66.7%) 2/10 (20%) 7/9 (77.8%) |0/4 (0%) 5/8 (62.5%) 7/8 (87.5%) 4/6 (66.7%) |
|TERMINAL (d) | 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 91 (I) 91 (I) 91 (I) |--- 92 (I) 92 (I) 92 (I) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.005 ** P=0.010 * P=0.234 P=0.002 ** |P=0.234 P=0.083 P=0.015 * P=0.085 |
|POLY 3 | P<0.001 ** P<0.001 ** P=0.067 P<0.001 ** |P=0.169 P=0.009 ** P<0.001 ** P=0.006 ** |
|POLY 1.5 | P<0.001 ** P<0.001 ** P=0.070 P<0.001 ** |P=0.169 P=0.010 * P<0.001 ** P=0.006 ** |
|POLY 6 | P<0.001 ** P<0.001 ** P=0.067 P<0.001 ** |P=0.168 P=0.009 ** P<0.001 ** P=0.006 ** |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.005 ** P=0.008 ** P=0.237 P<0.001 ** |P=0.230 P=0.071 P=0.010 * P=0.071 |
|=================================================================================================================================|
Date: 10/28/99 EXPERIMENT: 88124 TEST: 03 Page 6
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - INDIUM PHOSPHIDE
Terminal Sacrifice at 143 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Lymph Node, Bronchial |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/10 (0%) 1/6 (17%) 2/10 (20%) 5/9 (56%) |0/4 (0%) 1/8 (13%) 6/8 (75%) 3/6 (50%) |
|POLY-3 ADJUSTED (b)| 0.0% 99.6% 99.7% 99.9% |0.0% 99.5% 100.0% 99.9% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 1/6 (16.7%) 2/10 (20%) 5/9 (55.6%) |0/4 (0%) 1/8 (12.5%) 6/8 (75%) 3/6 (50%) |
|TERMINAL (d) | 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 91 (I) 91 (I) 91 (I) |--- 92 (I) 92 (I) 92 (I) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.006 ** P=0.398 P=0.234 P=0.015 * |P=0.113 P=0.638 P=0.039 * P=0.175 |
|POLY 3 | P<0.001 ** P=0.093 P=0.067 P<0.001 ** |P=0.053 P=0.245 P<0.001 ** P=0.037 * |
|POLY 1.5 | P<0.001 ** P=0.099 P=0.070 P<0.001 ** |P=0.054 P=0.255 P<0.001 ** P=0.039 * |
|POLY 6 | P<0.001 ** P=0.093 P=0.067 P<0.001 ** |P=0.053 P=0.245 P<0.001 ** P=0.037 * |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.006 ** P=0.375 P=0.237 P=0.011 * |P=0.109 P=0.667 P=0.030 * P=0.167 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Lymph Node, Mediastinal |
| Foreign Body |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/10 (0%) 3/5 (60%) 7/9 (78%) 7/9 (78%) |0/7 (0%) 6/9 (67%) 6/8 (75%) 5/9 (56%) |
|POLY-3 ADJUSTED (b)| 0.0% 99.9% 100.0% 100.0% |0.0% 100.0% 100.0% 99.9% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 3/5 (60%) 7/9 (77.8%) 7/9 (77.8%) |0/7 (0%) 6/9 (66.7%) 6/8 (75%) 5/9 (55.6%) |
|TERMINAL (d) | 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 91 (I) 91 (I) 91 (I) |--- 92 (I) 92 (I) 92 (I) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.007 ** P=0.024 * P=0.002 ** P=0.002 ** |P=0.246 P=0.016 * P=0.009 ** P=0.038 * |
|POLY 3 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P=0.178 P<0.001 ** P<0.001 ** P=0.003 ** |
|POLY 1.5 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P=0.179 P<0.001 ** P<0.001 ** P=0.003 ** |
|POLY 6 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P=0.178 P<0.001 ** P<0.001 ** P=0.003 ** |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.007 ** P=0.022 * P<0.001 ** P<0.001 ** |P=0.243 P=0.010 * P=0.006 ** P=0.029 * |
|=================================================================================================================================|
Date: 10/28/99 EXPERIMENT: 88124 TEST: 03 Page 7
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - INDIUM PHOSPHIDE
Terminal Sacrifice at 143 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Lymph Node, Mediastinal |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/10 (0%) 1/5 (20%) 6/9 (67%) 7/9 (78%) |0/7 (0%) 4/9 (44%) 3/8 (38%) 5/9 (56%) |
|POLY-3 ADJUSTED (b)| 0.0% 99.7% 100.0% 100.0% |0.0% 99.9% 99.9% 99.9% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 1/5 (20%) 6/9 (66.7%) 7/9 (77.8%) |0/7 (0%) 4/9 (44.4%) 3/8 (37.5%) 5/9 (55.6%) |
|TERMINAL (d) | 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 91 (I) 91 (I) 91 (I) |--- 92 (I) 92 (I) 92 (I) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001 ** P=0.362 P=0.005 ** P=0.002 ** |P=0.089 P=0.079 P=0.130 P=0.038 * |
|POLY 3 | P<0.001 ** P=0.071 P<0.001 ** P<0.001 ** |P=0.058 P=0.013 * P=0.028 * P=0.003 ** |
|POLY 1.5 | P<0.001 ** P=0.076 P<0.001 ** P<0.001 ** |P=0.059 P=0.014 * P=0.030 * P=0.003 ** |
|POLY 6 | P<0.001 ** P=0.071 P<0.001 ** P<0.001 ** |P=0.058 P=0.013 * P=0.028 * P=0.003 ** |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P<0.001 ** P=0.333 P=0.003 ** P<0.001 ** |P=0.086 P=0.069 P=0.123 P=0.029 * |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Nose |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |0/10 (0%) 0/10 (0%) 2/10 (20%) 0/10 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |0.0% 0.0% 99.7% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |0/10 (0%) 0/10 (0%) 2/10 (20%) 0/10 (0%) |
|TERMINAL (d) | 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- |--- --- 92 (I) --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.699N (e) P=0.234 (e) |
|POLY 3 | (e) (e) (e) (e) |P=0.462N (e) P=0.067 (e) |
|POLY 1.5 | (e) (e) (e) (e) |P=0.469N (e) P=0.070 (e) |
|POLY 6 | (e) (e) (e) (e) |P=0.462N (e) P=0.067 (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.701N (e) P=0.237 (e) |
|=================================================================================================================================|
Date: 10/28/99 EXPERIMENT: 88124 TEST: 03 Page 8
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - INDIUM PHOSPHIDE
Terminal Sacrifice at 143 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Stomach, Glandular |
| Mineralization |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 4/10 (40%) 0/0 (0%) 0/0 (0%) 4/10 (40%) |2/10 (20%) 0/0 (0%) 0/0 (0%) 1/10 (10%) |
|POLY-3 ADJUSTED (b)| 99.9% 0.0% 0.0% 99.9% |99.7% 0.0% 0.0% 99.3% |
|INT SACRIFICE 1 (c)| 4/10 (40%) 0/0 (0%) 0/0 (0%) 4/10 (40%) |2/10 (20%) 0/0 (0%) 0/0 (0%) 1/10 (10%) |
|TERMINAL (d) | 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 91 (I) --- --- 91 (I) |92 (I) --- --- 92 (I) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.617 P=1.000N P=1.000N P=0.672 |P=0.419N P=1.000N P=1.000N P=0.500N |
|POLY 3 | (e) (e) (e) P=0.569 |(e) (e) (e) P=0.299N |
|POLY 1.5 | (e) (e) (e) P=0.572 |(e) (e) (e) P=0.305N |
|POLY 6 | (e) (e) (e) P=0.569 |(e) (e) (e) P=0.299N |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.620 P=1.000 P=1.000 P=0.675N |P=0.417N P=1.000 P=1.000 P=0.500N |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Poly-3 adjusted lifetime tumor incidence.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death.
Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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