TDMS Study 88124-03 Pathology Tables
NTP Experiment-Test: 88124-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:33
FINAL#1 CORE STUDY RATS
Facility: Battelle Northwest
Chemical CAS #: 22398-80-7
Lock Date: 09/25/98
Cage Range: All
Reasons For Removal: 25022 Accidently Killed 25019 Moribund Sacrifice
25020 Natural Death 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88124-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.03 0.1MG/M3 0.3MG/M3
MG/M3 STOP STOP
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Early Deaths
Moribund Sacrifice 13 14 14 12
Natural Death 3 4 4
Accidently Killed 1
Survivors
Terminal Sacrifice 34 30 36 34
Moribund Sacrifice 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (47) (49) (50) (46)
Hemorrhage 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 2 (4%) 1 (2%) 1 (2%)
Basophilic Focus 46 (92%) 39 (78%) 47 (94%) 44 (88%)
Clear Cell Focus 17 (34%) 8 (16%) 17 (34%) 9 (18%)
Eosinophilic Focus 2 (4%) 5 (10%) 3 (6%) 5 (10%)
Fatty Change 4 (8%) 2 (4%) 4 (8%) 3 (6%)
Hepatodiaphragmatic Nodule 7 (14%) 4 (8%) 2 (4%) 11 (22%)
Inflammation, Chronic Active 1 (2%)
Inflammation, Granulomatous 1 (2%) 2 (4%) 1 (2%)
Mixed Cell Focus 6 (12%) 4 (8%) 4 (8%)
Necrosis 3 (6%) 3 (6%)
Regeneration 1 (2%) 2 (4%) 4 (8%)
Tension Lipidosis 1 (2%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic, Focal 4 (8%) 1 (2%) 1 (2%)
Bile Duct, Hyperplasia 4 (8%) 8 (16%) 4 (8%) 10 (20%)
Centrilobular, Necrosis 3 (6%) 7 (14%) 3 (6%) 9 (18%)
Periportal, Infiltration Cellular,
Mononuclear Cell 1 (2%)
Serosa, Hemorrhage 1 (2%)
Mesentery (9) (15) (15) (19)
Fat, Necrosis 9 (100%) 15 (100%) 15 (100%) 18 (95%)
Oral Mucosa (2) (2)
Pharyngeal, Hyperplasia 1 (50%)
Pancreas (50) (50) (50) (49)
Atrophy 5 (10%) 12 (24%) 6 (12%) 8 (16%)
Basophilic Focus 1 (2%) 3 (6%) 1 (2%)
Metaplasia, Hepatocyte 1 (2%)
Salivary Glands (50) (50) (50) (50)
Atrophy 3 (6%) 1 (2%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88124-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.03 0.1MG/M3 0.3MG/M3
MG/M3 STOP STOP
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Basophilic Focus 3 (6%) 2 (4%)
Stomach, Forestomach (50) (50) (50) (49)
Hyperplasia, Squamous 2 (4%) 1 (2%) 2 (4%)
Inflammation, Acute 1 (2%)
Necrosis 1 (2%)
Ulcer 1 (2%) 2 (4%) 1 (2%)
Stomach, Glandular (49) (50) (50) (48)
Necrosis 1 (2%) 5 (10%) 1 (2%) 2 (4%)
Tongue (1) (1) (1) (1)
Hyperplasia, Squamous 1 (100%) 1 (100%) 1 (100%)
Tooth (2)
Inflammation, Chronic Active 2 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 37 (74%) 29 (58%) 41 (82%) 30 (60%)
Atrium, Thrombosis 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (49) (50) (49)
Atrophy 2 (4%)
Degeneration, Cystic 3 (6%) 3 (6%) 2 (4%) 2 (4%)
Hyperplasia 21 (43%) 23 (47%) 27 (54%) 25 (51%)
Hypertrophy 11 (22%) 13 (27%) 3 (6%) 6 (12%)
Necrosis 4 (8%) 3 (6%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic 1 (2%) 1 (2%) 4 (8%)
Adrenal Medulla (50) (48) (50) (49)
Hyperplasia 6 (12%) 13 (27%) 9 (18%) 15 (31%)
Necrosis 1 (2%)
Islets, Pancreatic (50) (50) (50) (49)
Hyperplasia 1 (2%) 1 (2%)
Pituitary Gland (50) (50) (48) (49)
Cyst 1 (2%) 2 (4%)
Hemorrhage, Chronic 1 (2%)
Pars Distalis, Angiectasis 1 (2%) 2 (4%) 3 (6%) 1 (2%)
Pars Distalis, Hyperplasia 15 (30%) 15 (30%) 13 (27%) 17 (35%)
Thyroid Gland (47) (47) (50) (47)
C-Cell, Hyperplasia 41 (87%) 42 (89%) 42 (84%) 39 (83%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88124-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.03 0.1MG/M3 0.3MG/M3
MG/M3 STOP STOP
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (49) (47) (47) (49)
Cyst 1 (2%)
Hyperplasia 5 (10%) 1 (2%) 2 (4%) 4 (8%)
Ovary (50) (50) (50) (49)
Cyst 9 (18%) 6 (12%) 7 (14%) 3 (6%)
Inflammation, Granulomatous 2 (4%)
Interstitial Cell, Hyperplasia 1 (2%)
Uterus (50) (50) (50) (49)
Cyst 1 (2%) 1 (2%)
Inflammation, Acute 1 (2%) 1 (2%)
Thrombosis 1 (2%)
Ulcer 1 (2%)
Cervix, Hypertrophy 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (50) (50) (48)
Atrophy 1 (2%)
Inflammation, Granulomatous 1 (2%) 1 (2%)
Myelofibrosis 1 (2%) 1 (2%)
Lymph Node, Bronchial (25) (30) (35) (30)
Foreign Body 23 (77%) 26 (74%) 20 (67%)
Lymph Node, Mandibular (43) (48) (42) (42)
Infiltration Cellular, Plasma Cell 1 (2%)
Lymph Node, Mediastinal (28) (36) (39) (26)
Foreign Body 15 (42%) 18 (46%) 13 (50%)
Spleen (50) (50) (50) (47)
Fibrosis 1 (2%) 1 (2%) 4 (9%)
Hematopoietic Cell Proliferation 1 (2%) 3 (6%) 6 (12%) 2 (4%)
Hemorrhage 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Metaplasia, Osseous 1 (2%)
Necrosis 1 (2%)
Thymus (45) (47) (50) (45)
Atrophy 1 (2%)
Epithelial Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88124-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.03 0.1MG/M3 0.3MG/M3
MG/M3 STOP STOP
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Galactocele 2 (4%) 4 (8%) 1 (2%) 5 (10%)
Hyperplasia 1 (2%)
Skin (50) (49) (50) (49)
Foreign Body 1 (2%)
Hyperkeratosis 2 (4%)
Inflammation, Acute 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (49)
Osteopetrosis 6 (12%) 7 (14%) 6 (12%) 7 (14%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (49) (50) (49)
Inflammation, Acute 1 (2%) 1 (2%)
Epiglottis, Metaplasia, Squamous 3 (6%) 2 (4%) 1 (2%)
Respiratory Epithelium, Metaplasia, Squamous 4 (8%) 5 (10%) 4 (8%) 6 (12%)
Lung (50) (50) (50) (50)
Cyst, Squamous 1 (2%) 1 (2%) 10 (20%)
Foreign Body 1 (2%) 49 (98%) 50 (100%) 50 (100%)
Hyperplasia, Atypical 8 (16%) 8 (16%) 39 (78%)
Inflammation, Chronic Active 10 (20%) 49 (98%) 50 (100%) 49 (98%)
Metaplasia, Squamous 2 (4%) 1 (2%) 4 (8%)
Thrombosis 2 (4%)
Alveolar Epithelium, Hyperplasia 8 (16%) 15 (30%) 22 (44%) 16 (32%)
Alveolar Epithelium, Metaplasia 46 (92%) 47 (94%) 48 (96%)
Alveolus, Infiltration Cellular, Histiocyte 16 (32%) 1 (2%)
Alveolus, Proteinosis 49 (98%) 47 (94%) 50 (100%)
Bronchiole, Inflammation, Suppurative 1 (2%)
Interstitium, Fibrosis 48 (96%) 50 (100%) 49 (98%)
Mediastinum, Inflammation, Chronic 1 (2%)
Nose (50) (50) (50) (49)
Inflammation, Suppurative 6 (12%) 8 (16%) 3 (6%) 9 (18%)
Thrombosis 2 (4%) 3 (6%) 1 (2%) 6 (12%)
Glands, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88124-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.03 0.1MG/M3 0.3MG/M3
MG/M3 STOP STOP
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Lateral Wall, Metaplasia, Squamous 2 (4%)
Olfactory Epithelium, Metaplasia 1 (2%) 4 (8%) 1 (2%) 1 (2%)
Respiratory Epithelium, Hyperplasia 2 (4%) 4 (8%) 1 (2%) 7 (14%)
Respiratory Epithelium, Metaplasia, Squamous 3 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (3) (3)
Cataract 1 (100%) 3 (100%) 3 (100%)
Retina, Atrophy 1 (100%) 3 (100%) 3 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49) (50) (48)
Accumulation, Hyaline Droplet 1 (2%)
Infarct 1 (2%)
Nephropathy 41 (82%) 38 (78%) 42 (84%) 38 (79%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88124-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.03 0.1MG/M3 0.3MG/M3
MG/M3 STOP STOP
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Early Deaths
Moribund Sacrifice 20 18 16 15
Natural Death 3 3 5 9
Survivors
Terminal Sacrifice 27 29 29 26
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (48) (50) (46) (46)
Ulcer 1 (2%)
Intestine Small, Duodenum (49) (50) (47) (48)
Necrosis 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 2 (4%) 2 (4%) 2 (4%)
Basophilic Focus 29 (58%) 29 (58%) 31 (62%) 34 (68%)
Clear Cell Focus 18 (36%) 16 (32%) 22 (44%) 16 (32%)
Degeneration, Cystic 3 (6%) 9 (18%) 5 (10%) 5 (10%)
Eosinophilic Focus 3 (6%) 3 (6%) 4 (8%) 3 (6%)
Fatty Change 5 (10%) 5 (10%) 7 (14%) 3 (6%)
Hepatodiaphragmatic Nodule 3 (6%) 4 (8%) 2 (4%) 9 (18%)
Inflammation, Chronic Active 1 (2%)
Inflammation, Granulomatous 1 (2%) 1 (2%)
Mixed Cell Focus 1 (2%) 2 (4%)
Necrosis 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Regeneration 3 (6%)
Vacuolization Cytoplasmic, Focal 1 (2%)
Bile Duct, Hyperplasia 39 (78%) 42 (84%) 40 (80%) 36 (72%)
Centrilobular, Necrosis 5 (10%) 4 (8%) 6 (12%) 10 (20%)
Serosa, Fibrosis 1 (2%)
Serosa, Hemorrhage 1 (2%)
Mesentery (6) (6) (6) (8)
Artery, Inflammation, Chronic Active 1 (13%)
Artery, Mineralization 1 (13%)
Fat, Metaplasia, Osseous 1 (17%)
Fat, Necrosis 6 (100%) 6 (100%) 6 (100%) 6 (75%)
Oral Mucosa (1) (3) (2)
Gingival, Abscess 1 (50%)
Pancreas (50) (50) (50) (50)
Atrophy 14 (28%) 16 (32%) 17 (34%) 19 (38%)
Basophilic Focus 3 (6%) 3 (6%) 3 (6%)
Hyperplasia 2 (4%) 2 (4%) 4 (8%) 2 (4%)
Thrombosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88124-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.03 0.1MG/M3 0.3MG/M3
MG/M3 STOP STOP
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Duct, Hyperplasia 1 (2%)
Salivary Glands (50) (50) (50) (50)
Atrophy 2 (4%) 3 (6%) 2 (4%)
Basophilic Focus 2 (4%) 1 (2%)
Necrosis 1 (2%)
Duct, Metaplasia, Squamous 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Diverticulum 2 (4%)
Hyperplasia, Basal Cell 1 (2%)
Hyperplasia, Squamous 1 (2%) 1 (2%) 3 (6%) 2 (4%)
Inflammation, Acute 1 (2%) 3 (6%)
Necrosis 1 (2%)
Ulcer 1 (2%) 4 (8%) 1 (2%)
Stomach, Glandular (50) (50) (48) (49)
Mineralization 1 (2%) 1 (2%) 2 (4%) 3 (6%)
Necrosis 2 (4%) 2 (4%)
Tongue (2)
Hyperplasia, Squamous 2 (100%)
Tooth (2) (3) (1)
Developmental Malformation 1 (33%)
Inflammation, Chronic Active 2 (100%) 2 (67%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Necrosis, Fibrinoid 1 (100%)
Heart (50) (50) (50) (50)
Cardiomyopathy 44 (88%) 43 (86%) 43 (86%) 46 (92%)
Necrosis 1 (2%)
Artery, Mineralization 1 (2%) 1 (2%)
Atrium, Thrombosis 2 (4%) 3 (6%) 2 (4%) 1 (2%)
Epicardium, Fibrosis 1 (2%)
Mesothelium, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Atrophy 2 (4%) 1 (2%)
Degeneration, Cystic 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Hyperplasia 32 (64%) 27 (54%) 33 (66%) 33 (66%)
Hypertrophy 7 (14%) 5 (10%) 3 (6%) 9 (18%)
Necrosis 2 (4%) 2 (4%) 2 (4%) 4 (8%)
Vacuolization Cytoplasmic 1 (2%) 1 (2%)
Adrenal Medulla (50) (50) (49) (50)
Hyperplasia 26 (52%) 26 (52%) 24 (49%) 32 (64%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88124-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.03 0.1MG/M3 0.3MG/M3
MG/M3 STOP STOP
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Necrosis 1 (2%)
Thrombosis 1 (2%) 1 (2%)
Islets, Pancreatic (50) (50) (50) (50)
Hyperplasia 4 (8%) 3 (6%) 3 (6%) 1 (2%)
Parathyroid Gland (44) (44) (45) (45)
Hyperplasia 1 (2%)
Hypertrophy 1 (2%)
Pituitary Gland (49) (50) (50) (50)
Cyst 1 (2%)
Pars Distalis, Angiectasis 2 (4%)
Pars Distalis, Hyperplasia 5 (10%) 13 (26%) 12 (24%) 15 (30%)
Pars Intermedia, Angiectasis 1 (2%)
Pars Intermedia, Hyperplasia 1 (2%)
Thyroid Gland (49) (49) (48) (48)
C-Cell, Hyperplasia 41 (84%) 31 (63%) 42 (88%) 37 (77%)
Follicular Cell, Hyperplasia 2 (4%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Penis (1)
Inflammation, Suppurative 1 (100%)
Preputial Gland (50) (50) (50) (50)
Cyst 2 (4%) 1 (2%)
Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 3 (6%) 2 (4%) 2 (4%) 4 (8%)
Prostate (50) (50) (50) (50)
Hyperplasia 14 (28%) 13 (26%) 13 (26%) 9 (18%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 3 (6%) 3 (6%)
Inflammation, Suppurative 1 (2%)
Necrosis 1 (2%)
Testes (50) (50) (50) (50)
Atrophy 8 (16%) 4 (8%) 5 (10%) 10 (20%)
Necrosis 1 (2%)
Artery, Inflammation, Chronic Active 2 (4%) 1 (2%) 2 (4%)
Germinal Epithelium, Degeneration 1 (2%)
Interstitial Cell, Hyperplasia 6 (12%) 7 (14%) 6 (12%) 9 (18%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88124-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.03 0.1MG/M3 0.3MG/M3
MG/M3 STOP STOP
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (49) (50)
Hyperplasia, Reticulum Cell 1 (2%)
Necrosis 1 (2%)
Thrombosis 1 (2%)
Lymph Node (2) (4) (2)
Ectasia 1 (50%)
Lymph Node, Bronchial (26) (27) (41) (44)
Foreign Body 19 (70%) 27 (66%) 36 (82%)
Hyperplasia 1 (2%)
Lymph Node, Mandibular (44) (42) (47) (47)
Infiltration Cellular, Plasma Cell 1 (2%) 1 (2%)
Lymph Node, Mediastinal (25) (19) (45) (40)
Foreign Body 8 (42%) 27 (60%) 15 (38%)
Hyperplasia 1 (3%)
Spleen (50) (50) (49) (48)
Angiectasis 1 (2%)
Fibrosis 8 (16%) 15 (30%) 9 (18%) 11 (23%)
Hematopoietic Cell Proliferation 1 (2%) 2 (4%) 1 (2%)
Hemorrhage 2 (4%) 2 (4%) 1 (2%)
Hyperplasia, Focal 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Necrosis 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Thymus (47) (47) (46) (45)
Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (24) (33) (31) (24)
Galactocele 7 (29%) 4 (12%) 4 (13%) 5 (21%)
Inflammation, Chronic 1 (3%)
Skin (50) (50) (50) (49)
Cyst Epithelial Inclusion 1 (2%) 2 (4%)
Hyperkeratosis 3 (6%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 4 (8%) 4 (8%)
Necrosis 1 (2%)
Epidermis, Hyperplasia 1 (2%)
Prepuce, Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88124-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.03 0.1MG/M3 0.3MG/M3
MG/M3 STOP STOP
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Cyst Epithelial Inclusion 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic Active 1 (2%)
Artery, Inflammation 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (50) (50)
Hyperplasia, Squamous 1 (2%) 2 (4%)
Inflammation, Acute 2 (4%) 3 (6%) 5 (10%) 3 (6%)
Epiglottis, Metaplasia, Squamous 2 (4%) 1 (2%)
Respiratory Epithelium, Hyperplasia 1 (2%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%)
Lung (50) (50) (50) (50)
Cyst, Squamous 1 (2%) 3 (6%) 2 (4%)
Foreign Body 1 (2%) 50 (100%) 50 (100%) 50 (100%)
Hemorrhage 1 (2%)
Hyperplasia, Atypical 16 (32%) 23 (46%) 39 (78%)
Inflammation, Chronic Active 5 (10%) 50 (100%) 50 (100%) 50 (100%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Metaplasia, Squamous 1 (2%) 3 (6%) 4 (8%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 11 (22%) 20 (40%) 21 (42%) 31 (62%)
Alveolar Epithelium, Metaplasia 45 (90%) 45 (90%) 48 (96%)
Alveolus, Infiltration Cellular, Histiocyte 8 (16%)
Alveolus, Proteinosis 50 (100%) 48 (96%) 47 (94%)
Artery, Mediastinum, Mineralization 1 (2%)
Interstitium, Fibrosis 49 (98%) 50 (100%) 50 (100%)
Mediastinum, Thrombosis 1 (2%)
Nose (50) (50) (50) (50)
Inflammation, Suppurative 9 (18%) 10 (20%) 8 (16%) 8 (16%)
Thrombosis 4 (8%) 4 (8%) 6 (12%) 8 (16%)
Glands, Hyperplasia 1 (2%)
Lateral Wall, Metaplasia, Squamous 1 (2%)
Olfactory Epithelium, Atrophy 1 (2%) 2 (4%) 1 (2%)
Olfactory Epithelium, Metaplasia 6 (12%) 2 (4%) 2 (4%) 7 (14%)
Respiratory Epithelium, Hyperplasia 5 (10%) 7 (14%) 4 (8%) 5 (10%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Respiratory Epithelium, Necrosis 1 (2%)
Trachea (50) (50) (49) (49)
Inflammation, Suppurative 1 (2%) 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88124-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.03 0.1MG/M3 0.3MG/M3
MG/M3 STOP STOP
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1) (1) (1)
Cataract 1 (100%) 1 (100%) 1 (100%)
Retina, Atrophy 1 (100%) 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Accumulation, Hyaline Droplet 1 (2%)
Hydronephrosis 2 (4%)
Infarct 1 (2%) 2 (4%) 1 (2%)
Mineralization 1 (2%)
Nephropathy 47 (94%) 46 (92%) 43 (86%) 46 (92%)
Renal Tubule, Hyperplasia 1 (2%)
Urinary Bladder (50) (50) (49) (50)
Hemorrhage 2 (4%)
Inflammation, Chronic Active 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
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