TDMS Study 88124-03 Pathology Tables
NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 FINAL#1 CORE STUDY RATS Facility: Battelle Northwest Chemical CAS #: 22398-80-7 Lock Date: 09/25/98 Cage Range: All Reasons For Removal: 25022 Accidently Killed 25019 Moribund Sacrifice 25020 Natural Death 25021 Terminal Sacrifice Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 6| 7| 7| 7| 1| 7| 6| 7| 3| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5| 5| DAY ON TEST | 3| 3| 3| 3| 8| 1| 3| 3| 3| 2| 3| 6| 3| 9| 3| 3| 5| 3| 3| 3| 3| 6| 3| 6| 0| | 7| 5| 7| 7| 4| 5| 6| 7| 6| 4| 6| 7| 6| 7| 7| 6| 0| 6| 5| 7| 5| 9| 7| 6| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + A + + A + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + A + + A + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + A + + A + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X| __________________________________________________________________________| Mesentery | + + + +| __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + A + + + + + + + +| __________________________________________________________________________| Tongue | | __________________________________________________________________________| Tooth | + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + A + + + + + + + +| Adenoma | | Carcinoma | | Leukemia Mononuclear | X X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Parathyroid Gland | + + + M + + M + M + + + + + + + + + + + + M + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + A + + A + + + + + + + +| C-Cell, Adenoma | X X X X X | C-Cell, Carcinoma | X X | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 6| 7| 7| 7| 1| 7| 6| 7| 3| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5| 5| DAY ON TEST | 3| 3| 3| 3| 8| 1| 3| 3| 3| 2| 3| 6| 3| 9| 3| 3| 5| 3| 3| 3| 3| 6| 3| 6| 0| | 7| 5| 7| 7| 4| 5| 6| 7| 6| 4| 6| 7| 6| 7| 7| 6| 0| 6| 5| 7| 5| 9| 7| 6| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Granulosa Cell Tumor Benign | | Granulosa-Theca Tumor Malignant | X | Leukemia Mononuclear | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Polyp Stromal | X X X X | __________________________________________________________________________| Vagina | + | Leiomyosarcoma | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + A + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node | + | Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Bronchial | + + M M M + M M M M M M + + + + M M + + M M M M +| Leukemia Mononuclear | X X X| __________________________________________________________________________| Lymph Node, Mandibular | + M + + + + + + + + + M + + + M + + + + + M + + +| Leukemia Mononuclear | X X X X X X X X| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Leukemia Mononuclear | X X X X X X X| __________________________________________________________________________| Lymph Node, Mediastinal | M M M M M + M M M + M M + + + + + + + + + M + + +| Leukemia Mononuclear | X X X X X| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X| __________________________________________________________________________| Thymus | + + + M + M + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroadenoma | X X X X X X X X | Fibroadenoma, Multiple | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma | X | Sebaceous Gland, Carcinoma | | Subcutaneous Tissue, Fibroma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 6| 7| 7| 7| 1| 7| 6| 7| 3| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5| 5| DAY ON TEST | 3| 3| 3| 3| 8| 1| 3| 3| 3| 2| 3| 6| 3| 9| 3| 3| 5| 3| 3| 3| 3| 6| 3| 6| 0| | 7| 5| 7| 7| 4| 5| 6| 7| 6| 4| 6| 7| 6| 7| 7| 6| 0| 6| 5| 7| 5| 9| 7| 6| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Oligodendroglioma Malignant | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma | X | Carcinoma, Metastatic, Uncertain | | Primary Site | X | Leukemia Mononuclear | X X X X X X X| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Zymbal's Gland | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X| Lipoma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + M + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| | DAY ON TEST | 6| 3| 2| 3| 5| 7| 3| 3| 3| 3| 9| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| | | 7| 5| 6| 7| 1| 6| 7| 7| 5| 5| 0| 5| 1| 6| 6| 6| 6| 6| 7| 6| 7| 7| 5| 7| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X| 14 | __________________________________________________________________________|____________| Mesentery | + + + + + | 9 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Tongue | + | 1 | __________________________________________________________________________|____________| Tooth | | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 3 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | X | 1 | Carcinoma | X | 1 | Leukemia Mononuclear | | 3 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 3 | Pheochromocytoma Benign | X | 2 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + I M + + + + + + M + + M + M + + + + + + + M +| 40 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | Pars Distalis, Adenoma | X X X X X X X X X X X X X| 30 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 47 | C-Cell, Adenoma | X | 6 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| | DAY ON TEST | 6| 3| 2| 3| 5| 7| 3| 3| 3| 3| 9| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| | | 7| 5| 6| 7| 1| 6| 7| 7| 5| 5| 0| 5| 1| 6| 6| 6| 6| 6| 7| 6| 7| 7| 5| 7| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | C-Cell, Carcinoma | X | 3 | Follicular Cell, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 | Adenoma | X X X | 5 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granulosa Cell Tumor Benign | X | 1 | Granulosa-Theca Tumor Malignant | | 1 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | Polyp Stromal | X X X X X X | 10 | __________________________________________________________________________|____________| Vagina | | 1 | Leiomyosarcoma | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | | 3 | __________________________________________________________________________|____________| Lymph Node | | 1 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + M + M M M M M + + M M M + + + + + M +| 25 | Leukemia Mononuclear | X | 4 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + M M + + + + M + + + + + + + + + +| 43 | Leukemia Mononuclear | X | 9 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | | 1 | Leukemia Mononuclear | X X | 9 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + M M M + M M M M + M M + + M + + M +| 28 | Leukemia Mononuclear | X | 6 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X| 14 | __________________________________________________________________________|____________| Thymus | + + + + + + + M + + + + + + + + + + + + M M + + +| 45 | Leukemia Mononuclear | X | 5 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| | DAY ON TEST | 6| 3| 2| 3| 5| 7| 3| 3| 3| 3| 9| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| | | 7| 5| 6| 7| 1| 6| 7| 7| 5| 5| 0| 5| 1| 6| 6| 6| 6| 6| 7| 6| 7| 7| 5| 7| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibroadenoma | X X X X X X X X | 16 | Fibroadenoma, Multiple | X X X | 4 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Carcinoma | | 1 | Sebaceous Gland, Carcinoma | X | 1 | Subcutaneous Tissue, Fibroma | X X X | 3 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Oligodendroglioma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Carcinoma | | 1 | Carcinoma, Metastatic, Uncertain | | | Primary Site | | 1 | Leukemia Mononuclear | X | 8 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | __________________________________________________________________________|____________| Zymbal's Gland | + | 1 | Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 4 | Lipoma | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X| 14 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 _____________________________________________________________________________________________________________________ | 7| 1| 5| 7| 7| 6| 7| 4| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| DAY ON TEST | 2| 2| 6| 3| 3| 0| 3| 8| 3| 8| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 8| 8| 3| 3| 3| | 8| 0| 0| 6| 6| 7| 5| 1| 7| 6| 7| 5| 1| 7| 5| 7| 5| 7| 6| 6| 4| 3| 6| 7| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.03 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + A + + + A + + + + + + + + + + + + + + + + + + +| Polyp Adenomatous | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + A + + + A + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + A + + + A + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + A + + + A + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X | __________________________________________________________________________| Mesentery | + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Oral Mucosa | + | Pharyngeal, Squamous Cell Papilloma | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Tongue | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | Schwannoma Benign | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + A + + + + + + + + + + + + + + + + + + +| Adenoma | | Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Adrenal Medulla | + + + + + A + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | Pheochromocytoma Benign | X X X X| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | M M + M M + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + A + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X | C-Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 _____________________________________________________________________________________________________________________ | 7| 1| 5| 7| 7| 6| 7| 4| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| DAY ON TEST | 2| 2| 6| 3| 3| 0| 3| 8| 3| 8| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 8| 8| 3| 3| 3| | 8| 0| 0| 6| 6| 7| 5| 1| 7| 6| 7| 5| 1| 7| 5| 7| 5| 7| 6| 6| 4| 3| 6| 7| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.03 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + M + + + + + + + + + + + + + + + +| Adenoma | X X X X| Carcinoma | | Carcinoma, Multiple | X | Leukemia Mononuclear | | Bilateral, Carcinoma | X | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Granulosa Cell Tumor Malignant | | Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Polyp Stromal | X X | Sarcoma Stromal | | Schwannoma Malignant | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Lymph Node | + + | Leukemia Mononuclear | X X | Pancreatic, Leukemia Mononuclear | | Renal, Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Bronchial | M M + M M + M M M + M M M M + M M M M + M M + + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + M + + + A + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X | __________________________________________________________________________| Lymph Node, Mediastinal | + A + M M + M + M + M M + M + M M + M + + M + + +| Leukemia Mononuclear | X X X X X X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X | __________________________________________________________________________| Thymus | + A + + + + + + + + + + + + M + + + M + + + + + +| Leukemia Mononuclear | X X X X X | Thymoma Benign | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 _____________________________________________________________________________________________________________________ | 7| 1| 5| 7| 7| 6| 7| 4| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| DAY ON TEST | 2| 2| 6| 3| 3| 0| 3| 8| 3| 8| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 8| 8| 3| 3| 3| | 8| 0| 0| 6| 6| 7| 5| 1| 7| 6| 7| 5| 1| 7| 5| 7| 5| 7| 6| 6| 4| 3| 6| 7| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.03 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Carcinoma | X X X X X X | Fibroadenoma | X X X X X X| Fibroadenoma, Multiple | X X X X | Leukemia Mononuclear | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + A + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X | Alveolar/Bronchiolar Adenoma, | | Multiple | | Alveolar/Bronchiolar Carcinoma | X | Alveolar/Bronchiolar Carcinoma, | | Multiple | X | Leukemia Mononuclear | X X X X X X X X X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + A + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | Renal Tubule, Carcinoma | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 0| 5| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 1| 3| 2| 8| 3| 9| 3| 3| 3| 3| 9| 3| 1| 9| 3| 2| 9| 3| 3| 3| 3| 2| 3| 3| | | 5| 4| 6| 8| 0| 6| 5| 5| 7| 7| 6| 4| 5| 4| 5| 7| 6| 7| 7| 6| 6| 5| 5| 6| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 0.03 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Polyp Adenomatous | X | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + I + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + + A + +| 46 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + A + +| 46 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X| 20 | __________________________________________________________________________|____________| Mesentery | + + + + + + +| 15 | Leukemia Mononuclear | X| 1 | __________________________________________________________________________|____________| Oral Mucosa | + | 2 | Pharyngeal, Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X| 7 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X| 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X| 4 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Tongue | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X| 11 | Schwannoma Benign | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | X | 1 | Leukemia Mononuclear | X X X X X X| 12 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + I + + + + + + +| 48 | Leukemia Mononuclear | X X X X X| 11 | Pheochromocytoma Benign | X X | 6 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + M + + + + + M + M + + M + + + + + + +| 42 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 0| 5| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 1| 3| 2| 8| 3| 9| 3| 3| 3| 3| 9| 3| 1| 9| 3| 2| 9| 3| 3| 3| 3| 2| 3| 3| | | 5| 4| 6| 8| 0| 6| 5| 5| 7| 7| 6| 4| 5| 4| 5| 7| 6| 7| 7| 6| 6| 5| 5| 6| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 0.03 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Leukemia Mononuclear | X X X X X| 11 | Pars Distalis, Adenoma | X X X X X X X X X X X X X | 27 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + A + + + + + + + + + + A + +| 47 | C-Cell, Adenoma | X X X X | 6 | C-Cell, Carcinoma | X| 2 | Follicular Cell, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + M + + + + + + + + + + + + + + M + +| 47 | Adenoma | | 4 | Carcinoma | X | 1 | Carcinoma, Multiple | | 1 | Leukemia Mononuclear | X| 1 | Bilateral, Carcinoma | | 1 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granulosa Cell Tumor Malignant | X | 1 | Leukemia Mononuclear | X X X X| 10 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X| 4 | Polyp Stromal | X X | 4 | Sarcoma Stromal | X | 1 | Schwannoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X| 12 | __________________________________________________________________________|____________| Lymph Node | + + +| 5 | Leukemia Mononuclear | | 2 | Pancreatic, Leukemia Mononuclear | X X X| 3 | Renal, Leukemia Mononuclear | X| 2 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + M M + + + + + + M + + + + + + + + + +| 30 | Leukemia Mononuclear | X X X X X X X| 13 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X X X X X X X X| 17 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + + + + + +| 47 | Leukemia Mononuclear | X X X X X X X X| 18 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 0| 5| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 1| 3| 2| 8| 3| 9| 3| 3| 3| 3| 9| 3| 1| 9| 3| 2| 9| 3| 3| 3| 3| 2| 3| 3| | | 5| 4| 6| 8| 0| 6| 5| 5| 7| 7| 6| 4| 5| 4| 5| 7| 6| 7| 7| 6| 6| 5| 5| 6| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 0.03 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + M + + + + + + + M + + + + + + + + + +| 36 | Leukemia Mononuclear | X X X X X X X| 16 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X| 21 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Leukemia Mononuclear | X X X X X X X| 12 | Thymoma Benign | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | X X | 8 | Fibroadenoma | X X X X X X X X | 14 | Fibroadenoma, Multiple | X | 5 | Leukemia Mononuclear | X| 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + I + +| 49 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 4 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X X | 6 | Alveolar/Bronchiolar Adenoma, | | | Multiple | X | 1 | Alveolar/Bronchiolar Carcinoma | X | 2 | Alveolar/Bronchiolar Carcinoma, | | | Multiple | | 1 | Leukemia Mononuclear | X X X X X X X X| 19 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 0| 5| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 1| 3| 2| 8| 3| 9| 3| 3| 3| 3| 9| 3| 1| 9| 3| 2| 9| 3| 3| 3| 3| 2| 3| 3| | | 5| 4| 6| 8| 0| 6| 5| 5| 7| 7| 6| 4| 5| 4| 5| 7| 6| 7| 7| 6| 6| 5| 5| 6| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 0.03 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 | Leukemia Mononuclear | X X X X X X| 13 | Renal Tubule, Carcinoma | X| 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + I + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X| 5 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X| 21 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 6| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 6| 6| 6| DAY ON TEST | 3| 3| 3| 3| 4| 3| 3| 3| 1| 0| 1| 5| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 7| 8| 8| | 6| 6| 6| 7| 8| 5| 7| 6| 4| 0| 6| 6| 5| 7| 6| 7| 6| 6| 2| 7| 6| 6| 9| 6| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0.1MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Polyp Adenomatous | | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Mesentery | + + + + + + + | Leukemia Mononuclear | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Tongue | | Squamous Cell Carcinoma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + M + + M + + + + M M M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X | Pars Distalis, Carcinoma | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | | C-Cell, Adenoma | X X X | C-Cell, Carcinoma | X | Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 6| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 6| 6| 6| DAY ON TEST | 3| 3| 3| 3| 4| 3| 3| 3| 1| 0| 1| 5| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 7| 8| 8| | 6| 6| 6| 7| 8| 5| 7| 6| 4| 0| 6| 6| 5| 7| 6| 7| 6| 6| 2| 7| 6| 6| 9| 6| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0.1MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| Adenoma | X X | Carcinoma | X | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Granulosa Cell Tumor Malignant | | Granulosa Cell Tumor Benign | X| Leukemia Mononuclear | X X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyosarcoma | | Polyp Stromal | X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Lymph Node | + | Deep Cervical, Carcinoma, Metastatic,| | Thyroid Gland | X | __________________________________________________________________________| Lymph Node, Bronchial | M M M M M M + + + + + + + + M + + + + + + + M + M| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Lymph Node, Mandibular | + + M + + + + + + + + + + + + + M + + + + + + + +| Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Lymph Node, Mediastinal | M M M M + M + + + + + + + + + + + + + M + + M M M| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Thymoma Benign | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X X X | Fibroadenoma | X X X X X X X X X X| Fibroadenoma, Multiple | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | X | Keratoacanthoma | X | Subcutaneous Tissue, Fibroma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 6| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 6| 6| 6| DAY ON TEST | 3| 3| 3| 3| 4| 3| 3| 3| 1| 0| 1| 5| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 7| 8| 8| | 6| 6| 6| 7| 8| 5| 7| 6| 4| 0| 6| 6| 5| 7| 6| 7| 6| 6| 2| 7| 6| 6| 9| 6| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0.1MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | Rhabdomyosarcoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pituitary | | Gland | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Thyroid Gland | X | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X | Alveolar/Bronchiolar Adenoma, | | Multiple | | Alveolar/Bronchiolar Carcinoma | | Carcinoma, Metastatic, Thyroid Gland | X | Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Thyroid Gland | X | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Transitional Epithelium, Papilloma | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 8| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 6| 3| 3| 3| 3| 3| | | 7| 5| 6| 7| 5| 6| 5| 6| 6| 7| 7| 7| 6| 5| 5| 7| 7| 5| 7| 6| 6| 5| 7| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 0.1MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Polyp Adenomatous | X | 1 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X| 13 | __________________________________________________________________________|____________| Mesentery | + + + + + + + + | 15 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Tongue | + | 1 | Squamous Cell Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X| 5 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X| 4 | Pheochromocytoma Benign | X | 2 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + M M + + + + + + + + + + + + + + + + M + +| 42 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + I + + + + + + + + + + M + + + +| 48 | Leukemia Mononuclear | | 3 | Pars Distalis, Adenoma | X X X X X X X X X X X X| 29 | Pars Distalis, Carcinoma | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 8| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 6| 3| 3| 3| 3| 3| | | 7| 5| 6| 7| 5| 6| 5| 6| 6| 7| 7| 7| 6| 5| 5| 7| 7| 5| 7| 6| 6| 5| 7| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 0.1MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Bilateral, C-Cell, Adenoma | X| 1 | C-Cell, Adenoma | X X | 5 | C-Cell, Carcinoma | X | 2 | Follicular Cell, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + M + + + + + + + + + + + + + + + + + M + + + + +| 47 | Adenoma | X X | 4 | Carcinoma | X X | 3 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granulosa Cell Tumor Malignant | X | 1 | Granulosa Cell Tumor Benign | | 1 | Leukemia Mononuclear | X | 4 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leiomyosarcoma | X | 1 | Polyp Stromal | X X X X X X X | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X| 6 | __________________________________________________________________________|____________| Lymph Node | | 1 | Deep Cervical, Carcinoma, Metastatic,| | | Thyroid Gland | | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + M + M + + + + M + + + + + + M + + + M M + + + +| 35 | Leukemia Mononuclear | X X X| 8 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + M M + + M + M + + + + + + M + + M + + + + + + +| 42 | Leukemia Mononuclear | X X X X| 11 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X| 12 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + M + + + + + + + + + + + + + + M + + + +| 39 | Leukemia Mononuclear | X X X X X| 10 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X| 14 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 4 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 8| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 6| 3| 3| 3| 3| 3| | | 7| 5| 6| 7| 5| 6| 5| 6| 6| 7| 7| 7| 6| 5| 5| 7| 7| 5| 7| 6| 6| 5| 7| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 0.1MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Thymoma Benign | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | | 3 | Fibroadenoma | X X X X X X | 16 | Fibroadenoma, Multiple | X X | 2 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basal Cell Adenoma | | 1 | Keratoacanthoma | X | 2 | Subcutaneous Tissue, Fibroma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | Rhabdomyosarcoma | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Pituitary | | | Gland | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Thyroid Gland | | 1 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X | 4 | Alveolar/Bronchiolar Adenoma, | | | Multiple | X | 1 | Alveolar/Bronchiolar Carcinoma | X | 1 | Carcinoma, Metastatic, Thyroid Gland | | 1 | Leukemia Mononuclear | X X X X| 11 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Thyroid Gland | | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 8| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 6| 3| 3| 3| 3| 3| | | 7| 5| 6| 7| 5| 6| 5| 6| 6| 7| 7| 7| 6| 5| 5| 7| 7| 5| 7| 6| 6| 5| 7| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 0.1MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 5 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Transitional Epithelium, Papilloma | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X| 14 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 6| 5| 1| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| DAY ON TEST | 3| 9| 3| 3| 1| 3| 3| 3| 3| 1| 2| 5| 8| 8| 3| 3| 4| 3| 3| 3| 3| 5| 3| 3| 3| | 6| 3| 7| 7| 3| 5| 6| 6| 6| 9| 6| 6| 8| 6| 6| 5| 3| 5| 7| 5| 5| 6| 7| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0.3MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + A + + A + + + + + + + + + + +| Polyp Adenomatous | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + A + + A + + + + + + + + + + M| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + A + + A + + + + + + + + + + A| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + A + + A + + + + + + + + + + A| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + A + + A + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | | Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X X X X X X X | __________________________________________________________________________| Mesentery | + + + + + + + | Leukemia Mononuclear | X | __________________________________________________________________________| Oral Mucosa | + | Gingival, Squamous Cell Carcinoma | | Pharyngeal, Squamous Cell Carcinoma | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + A + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + A + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + A + + + + + + + + + + +| Carcinoid Tumor Benign | X | Leukemia Mononuclear | | __________________________________________________________________________| Tongue | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Schwannoma Benign | X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + A + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + A + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Pheochromocytoma Malignant | | Pheochromocytoma Benign | X X | Bilateral, Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + A + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + M + A + + + M + M M + M + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + A + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 6| 5| 1| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| DAY ON TEST | 3| 9| 3| 3| 1| 3| 3| 3| 3| 1| 2| 5| 8| 8| 3| 3| 4| 3| 3| 3| 3| 5| 3| 3| 3| | 6| 3| 7| 7| 3| 5| 6| 6| 6| 9| 6| 6| 8| 6| 6| 5| 3| 5| 7| 5| 5| 6| 7| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0.3MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Leukemia Mononuclear | X X X | Pars Distalis, Adenoma | X X X X X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + A + + + + + M + + + + +| Leukemia Mononuclear | | Bilateral, C-Cell, Adenoma | X | C-Cell, Adenoma | X | C-Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + A + + + + + + + + + + +| Adenoma | X X | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + A + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + A + + + + + + + + + + +| Polyp Stromal | X X X | Polyp Stromal, Multiple | X X| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + A + + A + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Lymph Node | + | Leukemia Mononuclear | X | Pancreatic, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Bronchial | + + + + M + + + + + M M + + + M + + + M + + + + M| Leukemia Mononuclear | X X X X X X X X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + M M| Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + A + + A + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + M + + + + + + + + + + + + M + M + M M M + M M| Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + A + + A + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X | __________________________________________________________________________| Thymus | + M + + + + + + + + M + + A + + + + + + + + + + +| Leukemia Mononuclear | X X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | Carcinoma, Multiple | X | Fibroadenoma | X X X X X | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 6| 5| 1| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| DAY ON TEST | 3| 9| 3| 3| 1| 3| 3| 3| 3| 1| 2| 5| 8| 8| 3| 3| 4| 3| 3| 3| 3| 5| 3| 3| 3| | 6| 3| 7| 7| 3| 5| 6| 6| 6| 9| 6| 6| 8| 6| 6| 5| 3| 5| 7| 5| 5| 6| 7| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0.3MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Fibroadenoma, Multiple | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Sarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + A + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X X | Alveolar/Bronchiolar Adenoma, | | Multiple | X | Alveolar/Bronchiolar Carcinoma | X X X | Alveolar/Bronchiolar Carcinoma, | | Multiple | X X X | Leukemia Mononuclear | X X X X X X X X X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + A + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + A + + A + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + A + + + + + + + + + + +| Leukemia Mononuclear | | Transitional Epithelium, Papilloma | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X X X X X X X | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| | DAY ON TEST | 3| 8| 3| 3| 3| 3| 1| 2| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 5| | | 7| 5| 6| 7| 5| 7| 1| 7| 7| 6| 6| 0| 6| 7| 6| 6| 7| 5| 6| 7| 6| 5| 8| 7| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 0.3MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Polyp Adenomatous | | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + A| 46 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + A| 48 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + A| 46 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Adenoma | X | 1 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X X X X X X X X X X| 24 | __________________________________________________________________________|____________| Mesentery | + + + + + + + + + + + +| 19 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Oral Mucosa | + | 2 | Gingival, Squamous Cell Carcinoma | X | 1 | Pharyngeal, Squamous Cell Carcinoma | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + A| 48 | Carcinoid Tumor Benign | | 1 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Tongue | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 6 | Schwannoma Benign | | 2 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X | 9 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X | 9 | Pheochromocytoma Malignant | X | 1 | Pheochromocytoma Benign | X X X X X | 7 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| | DAY ON TEST | 3| 8| 3| 3| 3| 3| 1| 2| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 5| | | 7| 5| 6| 7| 5| 7| 1| 7| 7| 6| 6| 0| 6| 7| 6| 6| 7| 5| 6| 7| 6| 5| 8| 7| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 0.3MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Bilateral, Pheochromocytoma Benign | X | 2 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | X | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + M + + + + + + M + + + + + I + + M + +| 39 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X | 6 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X| 25 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + A| 47 | Leukemia Mononuclear | X | 1 | Bilateral, C-Cell, Adenoma | | 1 | C-Cell, Adenoma | | 1 | C-Cell, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | X X X X | 6 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X | 8 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Polyp Stromal | X X X X X| 8 | Polyp Stromal, Multiple | | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X X X X X | 10 | __________________________________________________________________________|____________| Lymph Node | + | 2 | Leukemia Mononuclear | | 1 | Pancreatic, Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + M + + M M + + M + + M M + M M M M + M M I + M +| 30 | Leukemia Mononuclear | X X X X X | 14 | __________________________________________________________________________|____________| Lymph Node, Mandibular | M + + M + + + + + + + + M + M + + M + + M + + + +| 42 | Leukemia Mononuclear | X X X X X X X | 15 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + A| 47 | Leukemia Mononuclear | X X X X X X X X X | 18 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | M + + + + M + M M M + + M + M M M M M M M M + M M| 26 | Leukemia Mononuclear | X X X X | 11 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| | DAY ON TEST | 3| 8| 3| 3| 3| 3| 1| 2| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 5| | | 7| 5| 6| 7| 5| 7| 1| 7| 7| 6| 6| 0| 6| 7| 6| 6| 7| 5| 6| 7| 6| 5| 8| 7| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 0.3MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + A| 47 | Leukemia Mononuclear | X X X X X X X X X X | 23 | __________________________________________________________________________|____________| Thymus | + + + M + + + + + + + + + + + + + + + + M + + + +| 45 | Leukemia Mononuclear | X X X | 7 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | X | 1 | Carcinoma, Multiple | | 1 | Fibroadenoma | X X X X X X | 11 | Fibroadenoma, Multiple | | 1 | __________________________________________________________________________|____________| Skin | + I + + + + + + + + + + + + + + + + + + + + + + +| 49 | Subcutaneous Tissue, Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X X X X X X X X X X X X X| 18 | Alveolar/Bronchiolar Adenoma, | | | Multiple | | 1 | Alveolar/Bronchiolar Carcinoma | X | 4 | Alveolar/Bronchiolar Carcinoma, | | | Multiple | X X X X | 7 | Leukemia Mononuclear | X X X X X X X X | 19 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X X X X X | 12 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| | DAY ON TEST | 3| 8| 3| 3| 3| 3| 1| 2| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 5| | | 7| 5| 6| 7| 5| 7| 1| 7| 7| 6| 6| 0| 6| 7| 6| 6| 7| 5| 6| 7| 6| 5| 8| 7| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 0.3MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X | 2 | Transitional Epithelium, Papilloma | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X X X X X X X X X X| 24 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 4| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 2| 4| 3| 3| 1| 3| 1| 3| 3| 3| 3| 3| 0| 0| 3| 7| 7| 3| 3| 3| 3| 3| | 4| 3| 3| 4| 9| 4| 3| 4| 3| 7| 4| 3| 4| 7| 4| 9| 0| 4| 6| 2| 4| 4| 5| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + I + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + A + + + + + + + + + + A + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | Osteosarcoma, Metastatic, Bone | X | __________________________________________________________________________| Mesentery | + + + + + | __________________________________________________________________________| Oral Mucosa | | Pharyngeal, Squamous Cell Papilloma | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Leukemia Mononuclear | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tongue | + | __________________________________________________________________________| Tooth | + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Osteosarcoma, Metastatic, Bone | X | Schwannoma Benign | | Atrium, Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Pheochromocytoma Benign | X X X X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Carcinoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + + + M + M M + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 4| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 2| 4| 3| 3| 1| 3| 1| 3| 3| 3| 3| 3| 0| 0| 3| 7| 7| 3| 3| 3| 3| 3| | 4| 3| 3| 4| 9| 4| 3| 4| 3| 7| 4| 3| 4| 7| 4| 9| 0| 4| 6| 2| 4| 4| 5| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Leukemia Mononuclear | X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X| Pars Distalis, Carcinoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X X X| C-Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | + | Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Carcinoma | X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant | X | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X| Interstitial Cell, Adenoma | X X X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node | | Pancreatic, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Bronchial | + M M M + + M + M M + + + + M + + M M + M + M M M| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Lymph Node, Mandibular | + M M + + M M + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Lymph Node, Mediastinal | + M M M + + M M + + + + + + M + + M M + M + M M +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 4| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 2| 4| 3| 3| 1| 3| 1| 3| 3| 3| 3| 3| 0| 0| 3| 7| 7| 3| 3| 3| 3| 3| | 4| 3| 3| 4| 9| 4| 3| 4| 3| 7| 4| 3| 4| 7| 4| 9| 0| 4| 6| 2| 4| 4| 5| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M + M M M M + + + + + M + M + M M + M + + + +| Fibroadenoma | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X | Sebaceous Gland, Adenoma | | Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Fibrosarcoma | | Subcutaneous Tissue, Hemangiosarcoma | | Subcutaneous Tissue, Lipoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Adenoma, | | Multiple | X| Alveolar/Bronchiolar Carcinoma | | Carcinoma, Metastatic, Pituitary | | Gland | | Leukemia Mononuclear | X X X X | Osteosarcoma, Metastatic, Bone | X | Mediastinum, Osteosarcoma, | | Metastatic, Bone | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Chondroma | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | __________________________________________________________________________| Eye | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 4| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 2| 4| 3| 3| 1| 3| 1| 3| 3| 3| 3| 3| 0| 0| 3| 7| 7| 3| 3| 3| 3| 3| | 4| 3| 3| 4| 9| 4| 3| 4| 3| 7| 4| 3| 4| 7| 4| 9| 0| 4| 6| 2| 4| 4| 5| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Leukemia Mononuclear | X X X | Osteosarcoma, Metastatic, Bone | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 5| 7| 6| 6| 5| 7| 7| 4| 7| 7| 5| 7| 7| 7| 4| 1| 6| 7| 7| 6| 6| 7| | DAY ON TEST | 6| 3| 0| 5| 3| 5| 3| 5| 3| 3| 9| 3| 3| 2| 3| 3| 0| 0| 3| 7| 3| 3| 4| 9| 3| | | 9| 4| 0| 2| 4| 6| 9| 1| 3| 5| 5| 4| 3| 5| 3| 4| 3| 8| 5| 2| 3| 4| 7| 7| 4| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + I + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + A + +| 48 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + A + +| 48 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A + +| 47 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X | 15 | Osteosarcoma, Metastatic, Bone | | 1 | __________________________________________________________________________|____________| Mesentery | + | 6 | __________________________________________________________________________|____________| Oral Mucosa | + | 1 | Pharyngeal, Squamous Cell Papilloma | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Tongue | + | 2 | __________________________________________________________________________|____________| Tooth | | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + | 1 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 5 | Osteosarcoma, Metastatic, Bone | | 1 | Schwannoma Benign | X | 1 | Atrium, Mesothelioma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 8 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 7 | Pheochromocytoma Benign | X X X X X| 10 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 5| 7| 6| 6| 5| 7| 7| 4| 7| 7| 5| 7| 7| 7| 4| 1| 6| 7| 7| 6| 6| 7| | DAY ON TEST | 6| 3| 0| 5| 3| 5| 3| 5| 3| 3| 9| 3| 3| 2| 3| 3| 0| 0| 3| 7| 3| 3| 4| 9| 3| | | 9| 4| 0| 2| 4| 6| 9| 1| 3| 5| 5| 4| 3| 5| 3| 4| 3| 8| 5| 2| 3| 4| 7| 7| 4| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Adenoma | X | 1 | Carcinoma | X | 2 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + M + + + + + + + + + + + M + M + + + + + +| 44 | Adenoma | X| 1 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X | 5 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X| 36 | Pars Distalis, Carcinoma | X | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 | C-Cell, Adenoma | X | 5 | C-Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Peritoneum | | 1 | Mesothelioma Malignant | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X| 1 | Carcinoma | X | 2 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | Mesothelioma Malignant | | 1 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X | 27 | Interstitial Cell, Adenoma | X X X X X X X| 13 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X | 9 | __________________________________________________________________________|____________| Lymph Node | + + | 2 | Pancreatic, Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + M M + M M + + M + + + + + + + M + M M M + + M M| 26 | Leukemia Mononuclear | X X X X X X | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 5| 7| 6| 6| 5| 7| 7| 4| 7| 7| 5| 7| 7| 7| 4| 1| 6| 7| 7| 6| 6| 7| | DAY ON TEST | 6| 3| 0| 5| 3| 5| 3| 5| 3| 3| 9| 3| 3| 2| 3| 3| 0| 0| 3| 7| 3| 3| 4| 9| 3| | | 9| 4| 0| 2| 4| 6| 9| 1| 3| 5| 5| 4| 3| 5| 3| 4| 3| 8| 5| 2| 3| 4| 7| 7| 4| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + M + + + M + + + + + + + + +| 44 | Leukemia Mononuclear | X X X X X X | 11 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X | 13 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + M M + M + + + + M M M M + + M M + + M M M + M M| 25 | Leukemia Mononuclear | X X X X | 7 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X | 16 | __________________________________________________________________________|____________| Thymus | + M + + + + + + M + + M + + + + + + + + + + + + +| 47 | Leukemia Mononuclear | X X | 6 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M + + + M M M M M + M + M + + M M + + M M + +| 24 | Fibroadenoma | X | 2 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Keratoacanthoma | X | 2 | Sebaceous Gland, Adenoma | X | 1 | Subcutaneous Tissue, Fibroma | | 1 | Subcutaneous Tissue, Fibrosarcoma | X| 1 | Subcutaneous Tissue, Hemangiosarcoma | X | 1 | Subcutaneous Tissue, Lipoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteosarcoma | X X | 3 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Spinal Cord | + | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X X | 5 | Alveolar/Bronchiolar Adenoma, | | | Multiple | | 1 | Alveolar/Bronchiolar Carcinoma | X | 1 | Carcinoma, Metastatic, Pituitary | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 5| 7| 6| 6| 5| 7| 7| 4| 7| 7| 5| 7| 7| 7| 4| 1| 6| 7| 7| 6| 6| 7| | DAY ON TEST | 6| 3| 0| 5| 3| 5| 3| 5| 3| 3| 9| 3| 3| 2| 3| 3| 0| 0| 3| 7| 3| 3| 4| 9| 3| | | 9| 4| 0| 2| 4| 6| 9| 1| 3| 5| 5| 4| 3| 5| 3| 4| 3| 8| 5| 2| 3| 4| 7| 7| 4| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Gland | X | 1 | Leukemia Mononuclear | X X X X X X X X X | 13 | Osteosarcoma, Metastatic, Bone | X | 2 | Mediastinum, Osteosarcoma, | | | Metastatic, Bone | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Chondroma | X | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | 1 | __________________________________________________________________________|____________| Eye | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X | 10 | Osteosarcoma, Metastatic, Bone | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 2 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X | 16 | Mesothelioma Malignant | X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| DAY ON TEST | 3| 2| 3| 3| 2| 5| 3| 3| 1| 3| 3| 8| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 0| 3| | 3| 3| 5| 3| 8| 8| 4| 5| 4| 4| 5| 4| 3| 3| 3| 4| 3| 4| 3| 3| 3| 3| 4| 0| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.03 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | X| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Cholangiocarcinoma | | Cholangioma | | Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X X X X X X X| __________________________________________________________________________| Mesentery | + + | Leukemia Mononuclear | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | | Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | | Leukemia Mononuclear | X X X X X| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X| Pheochromocytoma Malignant | X X | Pheochromocytoma Complex | | Pheochromocytoma Benign | X X X X X X X X X | Bilateral, Pheochromocytoma Benign | X X X| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| DAY ON TEST | 3| 2| 3| 3| 2| 5| 3| 3| 1| 3| 3| 8| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 0| 3| | 3| 3| 5| 3| 8| 8| 4| 5| 4| 4| 5| 4| 3| 3| 3| 4| 3| 4| 3| 3| 3| 3| 4| 0| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.03 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Parathyroid Gland | + + + M + M + M + + + + + M + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X| Pars Distalis, Carcinoma | X | Pars Intermedia, Adenoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | | C-Cell, Adenoma | X X X X X| C-Cell, Carcinoma | X | Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | | Histiocytic Sarcoma | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Histiocytic Sarcoma | | Leukemia Mononuclear | X X | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X| Interstitial Cell, Adenoma | X X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X| __________________________________________________________________________| Lymph Node | + + | Leukemia Mononuclear | | Deep Cervical, Leukemia Mononuclear | | Pancreatic, Leukemia Mononuclear | X X | Renal, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Bronchial | M M M + + + + M + M + M M + M + M M M + + + M + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X| __________________________________________________________________________| Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + M M + + + + + +| Leukemia Mononuclear | X X X X X X X X| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| DAY ON TEST | 3| 2| 3| 3| 2| 5| 3| 3| 1| 3| 3| 8| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 0| 3| | 3| 3| 5| 3| 8| 8| 4| 5| 4| 4| 5| 4| 3| 3| 3| 4| 3| 4| 3| 3| 3| 3| 4| 0| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.03 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X| __________________________________________________________________________| Lymph Node, Mediastinal | M M M M + M M M + M + M M M M + M M M M M M M + +| Leukemia Mononuclear | X X X X| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X| __________________________________________________________________________| Thymus | + + + + + + + + + + + M + + + + + + M + + + + + +| Leukemia Mononuclear | X X| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M + M + M + + + + M + M M + + + M + M M + + M M +| Fibroadenoma | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Keratoacanthoma | X X X | Keratoacanthoma, Multiple | | Sebaceous Gland, Adenoma | X | Subcutaneous Tissue, Fibroma | X X X | Subcutaneous Tissue, Fibrosarcoma | X | Subcutaneous Tissue, Lipoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosarcoma, Metastatic, Skin | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Glioma Benign | | Histiocytic Sarcoma | X | Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Thyroid Gland | X | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X X | Alveolar/Bronchiolar Adenoma, | | Multiple | X X X | Alveolar/Bronchiolar Carcinoma | X X X X| Alveolar/Bronchiolar Carcinoma, | | Multiple | X | Carcinoma, Metastatic, Pituitary | | Gland | X | Carcinoma, Metastatic, Thyroid Gland | X | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| DAY ON TEST | 3| 2| 3| 3| 2| 5| 3| 3| 1| 3| 3| 8| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 0| 3| | 3| 3| 5| 3| 8| 8| 4| 5| 4| 4| 5| 4| 3| 3| 3| 4| 3| 4| 3| 3| 3| 3| 4| 0| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.03 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X X X X| Pheochromocytoma Malignant, | | Metastatic, Adrenal Medulla | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Pleura | | Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | | Histiocytic Sarcoma | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Zymbal's Gland | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X X X X X X X| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 6| 5| 7| 6| 6| 2| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 5| | DAY ON TEST | 3| 8| 3| 0| 3| 4| 0| 8| 6| 0| 8| 9| 8| 3| 3| 7| 3| 8| 3| 3| 3| 3| 3| 3| 2| | | 5| 3| 3| 2| 4| 3| 1| 6| 9| 7| 5| 5| 5| 3| 3| 6| 3| 6| 4| 4| 4| 4| 4| 5| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0.03 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + A + + A + + + + + + + + + + + + + + +| 48 | Carcinoma | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cholangiocarcinoma | X | 1 | Cholangioma | X | 1 | Histiocytic Sarcoma | X | 1 | Leukemia Mononuclear | X X X X X X X X X | 21 | __________________________________________________________________________|____________| Mesentery | + + + + | 6 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 1 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | X | 1 | Leukemia Mononuclear | X | 3 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | Carcinoma | X | 1 | Leukemia Mononuclear | X X X | 8 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 9 | Pheochromocytoma Malignant | X | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 6| 5| 7| 6| 6| 2| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 5| | DAY ON TEST | 3| 8| 3| 0| 3| 4| 0| 8| 6| 0| 8| 9| 8| 3| 3| 7| 3| 8| 3| 3| 3| 3| 3| 3| 2| | | 5| 3| 3| 2| 4| 3| 1| 6| 9| 7| 5| 5| 5| 3| 3| 6| 3| 6| 4| 4| 4| 4| 4| 5| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0.03 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Pheochromocytoma Complex | X | 1 | Pheochromocytoma Benign | X X X X X X X | 16 | Bilateral, Pheochromocytoma Benign | X X X | 6 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 2 | __________________________________________________________________________|____________| Parathyroid Gland | + + + M M + + + + + + + + + + + + + + + + + + + +| 44 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 3 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X| 33 | Pars Distalis, Carcinoma | | 1 | Pars Intermedia, Adenoma | X | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Bilateral, C-Cell, Adenoma | X | 1 | C-Cell, Adenoma | X X | 7 | C-Cell, Carcinoma | X X X | 4 | Follicular Cell, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Peritoneum | + | 1 | Histiocytic Sarcoma | X | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 2 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 2 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 | Adenoma | | 1 | Histiocytic Sarcoma | X | 1 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X | 25 | Interstitial Cell, Adenoma | X X X X X | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 9 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 6| 5| 7| 6| 6| 2| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 5| | DAY ON TEST | 3| 8| 3| 0| 3| 4| 0| 8| 6| 0| 8| 9| 8| 3| 3| 7| 3| 8| 3| 3| 3| 3| 3| 3| 2| | | 5| 3| 3| 2| 4| 3| 1| 6| 9| 7| 5| 5| 5| 3| 3| 6| 3| 6| 4| 4| 4| 4| 4| 5| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0.03 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node | + + | 4 | Leukemia Mononuclear | X | 1 | Deep Cervical, Leukemia Mononuclear | X | 1 | Pancreatic, Leukemia Mononuclear | X | 3 | Renal, Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | M + M M + + + M + M + M M + + + + + + + M M + M M| 27 | Histiocytic Sarcoma | X | 1 | Leukemia Mononuclear | X X X X X X | 11 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + M + + + M + + + + + + + M + M + + + + + + M| 42 | Leukemia Mononuclear | X X X X X X X X | 16 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X | 18 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | M M M M M + M M + + + M + + + + + + + + M M + M M| 19 | Leukemia Mononuclear | X X X X X | 9 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X | 23 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + M + + + + + + + + + + + + + +| 47 | Leukemia Mononuclear | X X | 4 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + M + M + + M + + + + + + + M + M + + + M| 33 | Fibroadenoma | | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 1 | Keratoacanthoma | | 3 | Keratoacanthoma, Multiple | X | 1 | Sebaceous Gland, Adenoma | | 1 | Subcutaneous Tissue, Fibroma | X | 4 | Subcutaneous Tissue, Fibrosarcoma | X | 2 | Subcutaneous Tissue, Lipoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosarcoma, Metastatic, Skin | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Glioma Benign | X | 1 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 6| 5| 7| 6| 6| 2| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 5| | DAY ON TEST | 3| 8| 3| 0| 3| 4| 0| 8| 6| 0| 8| 9| 8| 3| 3| 7| 3| 8| 3| 3| 3| 3| 3| 3| 2| | | 5| 3| 3| 2| 4| 3| 1| 6| 9| 7| 5| 5| 5| 3| 3| 6| 3| 6| 4| 4| 4| 4| 4| 5| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0.03 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | Leukemia Mononuclear | X | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Thyroid Gland | | 1 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X X X | 8 | Alveolar/Bronchiolar Adenoma, | | | Multiple | X X | 5 | Alveolar/Bronchiolar Carcinoma | X X X X | 8 | Alveolar/Bronchiolar Carcinoma, | | | Multiple | X | 2 | Carcinoma, Metastatic, Pituitary | | | Gland | | 1 | Carcinoma, Metastatic, Thyroid Gland | | 1 | Histiocytic Sarcoma | X | 1 | Leukemia Mononuclear | X X X X X X X | 16 | Pheochromocytoma Malignant, | | | Metastatic, Adrenal Medulla | X | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Pleura | + + | 2 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | X | 1 | Histiocytic Sarcoma | X | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | __________________________________________________________________________|____________| Zymbal's Gland | + | 1 | Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 1 | Leukemia Mononuclear | X X X X X X | 9 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 2 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 44 NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 6| 5| 7| 6| 6| 2| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 5| | DAY ON TEST | 3| 8| 3| 0| 3| 4| 0| 8| 6| 0| 8| 9| 8| 3| 3| 7| 3| 8| 3| 3| 3| 3| 3| 3| 2| | | 5| 3| 3| 2| 4| 3| 1| 6| 9| 7| 5| 5| 5| 3| 3| 6| 3| 6| 4| 4| 4| 4| 4| 5| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0.03 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | | | Histiocytic Sarcoma | X X | 3 | Leukemia Mononuclear | X X X X X X X X X X | 23 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 _____________________________________________________________________________________________________________________ | 7| 4| 6| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 6| 6| DAY ON TEST | 3| 9| 6| 5| 3| 3| 3| 3| 3| 5| 3| 3| 3| 0| 3| 3| 1| 3| 7| 3| 6| 4| 3| 9| 5| | 3| 3| 7| 2| 3| 4| 4| 3| 4| 8| 4| 4| 3| 0| 3| 5| 0| 4| 9| 3| 5| 4| 3| 8| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.1MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + A + + + + + + + + + + + + + + A + + + A + + + +| Leukemia Mononuclear | X X | Polyp Adenomatous | X | __________________________________________________________________________| Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Intestine Large, Cecum | + A + + + + + + + + + + + + + + A + + + A + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + A + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Ileum | + A + + + + + + + + + + + + + + A + + + A + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | X | Leukemia Mononuclear | X X X X X X X X X X X| __________________________________________________________________________| Mesentery | + + + + + | __________________________________________________________________________| Oral Mucosa | + + | Gingival, Squamous Cell Papilloma | X | Pharyngeal, Squamous Cell Papilloma | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyosarcoma | | __________________________________________________________________________| Stomach, Glandular | + A + + + + + + + + + + + + + + + + + + A + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Pericardium, Alveolar/Bronchiolar | | Carcinoma, Metastatic, Lung | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X| Pheochromocytoma Malignant | X | Pheochromocytoma Benign | X X X X X X | Bilateral, Pheochromocytoma Benign | X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 _____________________________________________________________________________________________________________________ | 7| 4| 6| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 6| 6| DAY ON TEST | 3| 9| 6| 5| 3| 3| 3| 3| 3| 5| 3| 3| 3| 0| 3| 3| 1| 3| 7| 3| 6| 4| 3| 9| 5| | 3| 3| 7| 2| 3| 4| 4| 3| 4| 8| 4| 4| 3| 0| 3| 5| 0| 4| 9| 3| 5| 4| 3| 8| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.1MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Carcinoma | X X X| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X| __________________________________________________________________________| Thyroid Gland | + A + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X X | C-Cell, Carcinoma | X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Coagulating Gland | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Adenoma, Multiple | X | __________________________________________________________________________| Seminal Vesicle | + A + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X| Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X| Interstitial Cell, Adenoma | X X X X X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X| __________________________________________________________________________| Lymph Node, Bronchial | + + M + + + M + + + + + + + + M + + M + + + + + M| Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M + + + + +| Leukemia Mononuclear | X X X X X X X X X| __________________________________________________________________________| Lymph Node, Mesenteric | + + I + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X| __________________________________________________________________________| Lymph Node, Mediastinal | + + M + + M + + + M + + + + + + M + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X| __________________________________________________________________________| Spleen | + A + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X| __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + M + + + + +| Leukemia Mononuclear | X X X X X X X| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 _____________________________________________________________________________________________________________________ | 7| 4| 6| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 6| 6| DAY ON TEST | 3| 9| 6| 5| 3| 3| 3| 3| 3| 5| 3| 3| 3| 0| 3| 3| 1| 3| 7| 3| 6| 4| 3| 9| 5| | 3| 3| 7| 2| 3| 4| 4| 3| 4| 8| 4| 4| 3| 0| 3| 5| 0| 4| 9| 3| 5| 4| 3| 8| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.1MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Mammary Gland | M + M + M + + M + M + + + + + + + M + + + M M + M| Carcinoma | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X | Trichoepithelioma | X | Subcutaneous Tissue, Fibroma | X X | Subcutaneous Tissue, Fibrosarcoma | | Subcutaneous Tissue, Lipoma | X | Subcutaneous Tissue, Liposarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteoma | X | Osteosarcoma | | __________________________________________________________________________| Skeletal Muscle | + | Rhabdomyosarcoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X X X X X X X | Alveolar/Bronchiolar Adenoma, | | Multiple | X X X X | Alveolar/Bronchiolar Carcinoma | X X X X X X | Alveolar/Bronchiolar Carcinoma, | | Multiple | | Leukemia Mononuclear | X X X X X X X X X X| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Esthesioneuroblastoma | | Osteosarcoma, Metastatic, Bone | | __________________________________________________________________________| Trachea | + A + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Zymbal's Gland | + | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 _____________________________________________________________________________________________________________________ | 7| 4| 6| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 6| 6| DAY ON TEST | 3| 9| 6| 5| 3| 3| 3| 3| 3| 5| 3| 3| 3| 0| 3| 3| 1| 3| 7| 3| 6| 4| 3| 9| 5| | 3| 3| 7| 2| 3| 4| 4| 3| 4| 8| 4| 4| 3| 0| 3| 5| 0| 4| 9| 3| 5| 4| 3| 8| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.1MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Leukemia Mononuclear | X X X X X X X X | Liposarcoma | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Transitional Epithelium, Papilloma | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X| Mesothelioma Malignant | X| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 5| 7| 4| 7| 6| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 6| 6| 6| | DAY ON TEST | 3| 1| 3| 3| 3| 6| 3| 3| 3| 3| 0| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 5| 4| 4| | | 3| 3| 4| 7| 5| 0| 4| 0| 4| 4| 3| 4| 3| 4| 5| 2| 4| 4| 5| 4| 3| 5| 1| 4| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 0.1MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Leukemia Mononuclear | X | 3 | Polyp Adenomatous | | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + A + + + + + + + + + + + + + + + + +| 46 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + A + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + A + + + + + A + + + + + + + + + + + + + + + + +| 46 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + + + + + +| 46 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Adenoma | | 1 | Leukemia Mononuclear | X X X X X X X X X X X X X X | 25 | __________________________________________________________________________|____________| Mesentery | + | 6 | __________________________________________________________________________|____________| Oral Mucosa | + | 3 | Gingival, Squamous Cell Papilloma | X | 2 | Pharyngeal, Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leiomyosarcoma | X | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Tooth | + + | 3 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 4 | Pericardium, Alveolar/Bronchiolar | | | Carcinoma, Metastatic, Lung | X | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 10 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + I + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 5| 7| 4| 7| 6| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 6| 6| 6| | DAY ON TEST | 3| 1| 3| 3| 3| 6| 3| 3| 3| 3| 0| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 5| 4| 4| | | 3| 3| 4| 7| 5| 0| 4| 0| 4| 4| 3| 4| 3| 4| 5| 2| 4| 4| 5| 4| 3| 5| 1| 4| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 0.1MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Pheochromocytoma Malignant | X X | 3 | Pheochromocytoma Benign | X X X X X X | 12 | Bilateral, Pheochromocytoma Benign | X X | 4 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 2 | Carcinoma | X| 4 | __________________________________________________________________________|____________| Parathyroid Gland | + + + M + + + + + M + + + M + + + + M + + + + + +| 45 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 4 | Pars Distalis, Adenoma | X X X X X X X X X X X X | 31 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 | C-Cell, Adenoma | X | 4 | C-Cell, Carcinoma | X | 3 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Coagulating Gland | + | 1 | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | X | 1 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | Adenoma, Multiple | | 1 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant | | 1 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X| 26 | Interstitial Cell, Adenoma | X X X X X X X | 15 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X | 13 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + M + M + M + + + + + + + + + + + + + + + + + + M| 41 | Leukemia Mononuclear | X X X X X X X X X X | 18 | __________________________________________________________________________|____________| Lymph Node, Mandibular | M + M + + + + + + + + + + + + + + + + + + + + + +| 47 | Leukemia Mononuclear | X X X X X X X X X X X | 20 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 5| 7| 4| 7| 6| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 6| 6| 6| | DAY ON TEST | 3| 1| 3| 3| 3| 6| 3| 3| 3| 3| 0| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 5| 4| 4| | | 3| 3| 4| 7| 5| 0| 4| 0| 4| 4| 3| 4| 3| 4| 5| 2| 4| 4| 5| 4| 3| 5| 1| 4| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 0.1MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X X X X X X X X X | 23 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + M + + + + + + + + + +| 45 | Leukemia Mononuclear | X X X X X X X X X X X | 20 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X X X X X X X X X X X | 28 | __________________________________________________________________________|____________| Thymus | + + + I + + + + + + + + + + + + + + + + + I M + +| 46 | Leukemia Mononuclear | X X X | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M + M M + + + M + M + + + M + M M + I + + + + + M| 31 | Carcinoma | X | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Keratoacanthoma | X X X X | 5 | Trichoepithelioma | | 1 | Subcutaneous Tissue, Fibroma | X X X X X | 7 | Subcutaneous Tissue, Fibrosarcoma | X | 1 | Subcutaneous Tissue, Lipoma | X | 2 | Subcutaneous Tissue, Liposarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteoma | | 1 | Osteosarcoma | X | 1 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | Rhabdomyosarcoma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 3 | __________________________________________________________________________|____________| Spinal Cord | +| 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X X X X X X X X X| 19 | Alveolar/Bronchiolar Adenoma, | | | Multiple | X X X X | 8 | Alveolar/Bronchiolar Carcinoma | X | 7 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 5| 7| 4| 7| 6| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 6| 6| 6| | DAY ON TEST | 3| 1| 3| 3| 3| 6| 3| 3| 3| 3| 0| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 5| 4| 4| | | 3| 3| 4| 7| 5| 0| 4| 0| 4| 4| 3| 4| 3| 4| 5| 2| 4| 4| 5| 4| 3| 5| 1| 4| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 0.1MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Alveolar/Bronchiolar Carcinoma, | | | Multiple | X | 1 | Leukemia Mononuclear | X X X X X X X X X | 19 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Esthesioneuroblastoma | X | 1 | Osteosarcoma, Metastatic, Bone | X | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | __________________________________________________________________________|____________| Zymbal's Gland | | 1 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X | 15 | Liposarcoma | X | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + M + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 2 | Transitional Epithelium, Papilloma | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X X X X | 29 | Mesothelioma Malignant | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 _____________________________________________________________________________________________________________________ | 6| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 5| 7| 7| 7| 7| 5| DAY ON TEST | 7| 3| 3| 4| 3| 8| 3| 6| 3| 3| 3| 9| 3| 3| 3| 4| 3| 3| 7| 3| 3| 3| 3| 3| 6| | 6| 4| 3| 7| 3| 4| 5| 0| 4| 3| 3| 5| 3| 3| 3| 5| 0| 3| 6| 2| 5| 5| 3| 3| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0.3MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + A + + + + + + + + + + + + A + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Jejunum | A + + A + A + + + + + + + + + + A + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Ileum | A + + A + + + + + + + + + + + + A + + + + + + + A| Leukemia Mononuclear | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Cholangiocarcinoma | X | Leukemia Mononuclear | X X X X X X X X X | __________________________________________________________________________| Mesentery | + + + + +| Squamous Cell Carcinoma, Metastatic, | | Lung | X| __________________________________________________________________________| Oral Mucosa | | Pharyngeal, Squamous Cell Papilloma | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Squamous Cell Carcinoma, Metastatic, | | Lung | X| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | | Leukemia Mononuclear | X X | Schwannoma Benign | X | Squamous Cell Carcinoma, Metastatic, | | Lung | X| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | Squamous Cell Carcinoma, Metastatic, | | Lung | X | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 _____________________________________________________________________________________________________________________ | 6| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 5| 7| 7| 7| 7| 5| DAY ON TEST | 7| 3| 3| 4| 3| 8| 3| 6| 3| 3| 3| 9| 3| 3| 3| 4| 3| 3| 7| 3| 3| 3| 3| 3| 6| | 6| 4| 3| 7| 3| 4| 5| 0| 4| 3| 3| 5| 3| 3| 3| 5| 0| 3| 6| 2| 5| 5| 3| 3| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0.3MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | Pheochromocytoma Malignant | X | Pheochromocytoma Benign | X X X X X X X X | Squamous Cell Carcinoma, Metastatic, | | Lung | X | Bilateral, Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X X | Squamous Cell Carcinoma, Metastatic, | | Lung | X | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + M + + + M M M + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + A + + + + + + + +| C-Cell, Adenoma | X X X | C-Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | Chemodectoma Malignant | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Penis | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X| Interstitial Cell, Adenoma | X X X X X X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Lymph Node | + +| Deep Cervical, Leukemia Mononuclear | X | Iliac, Leukemia Mononuclear | X | Renal, Squamous Cell Carcinoma, | | Metastatic, Lung | X| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 _____________________________________________________________________________________________________________________ | 6| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 5| 7| 7| 7| 7| 5| DAY ON TEST | 7| 3| 3| 4| 3| 8| 3| 6| 3| 3| 3| 9| 3| 3| 3| 4| 3| 3| 7| 3| 3| 3| 3| 3| 6| | 6| 4| 3| 7| 3| 4| 5| 0| 4| 3| 3| 5| 3| 3| 3| 5| 0| 3| 6| 2| 5| 5| 3| 3| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0.3MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + + + + + + M + + + + + + M + + + + + +| Leukemia Mononuclear | X X X X X X | Squamous Cell Carcinoma, Metastatic, | | Lung | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | Squamous Cell Carcinoma, Metastatic, | | Lung | X| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Lymph Node, Mediastinal | M + + + M M + + + + M M + + + + M + + + + + + + +| Leukemia Mononuclear | X X X X X | Squamous Cell Carcinoma, Metastatic, | | Lung | X X| __________________________________________________________________________| Spleen | + + + A + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | __________________________________________________________________________| Thymus | + + + + + + + + + + + M + + + M + + + + + + + + +| Leukemia Mononuclear | X X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M M M M M M M + + M M + + M M M M + M + + M + M| Carcinoma | X | Fibroadenoma | X | __________________________________________________________________________| Skin | + + + + + I + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X | Leukemia Mononuclear | | Squamous Cell Papilloma | X | Subcutaneous Tissue, Fibroma | | Subcutaneous Tissue, Fibrosarcoma | | Subcutaneous Tissue, Lipoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X X X X X X | Alveolar/Bronchiolar Adenoma, | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 _____________________________________________________________________________________________________________________ | 6| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 5| 7| 7| 7| 7| 5| DAY ON TEST | 7| 3| 3| 4| 3| 8| 3| 6| 3| 3| 3| 9| 3| 3| 3| 4| 3| 3| 7| 3| 3| 3| 3| 3| 6| | 6| 4| 3| 7| 3| 4| 5| 0| 4| 3| 3| 5| 3| 3| 3| 5| 0| 3| 6| 2| 5| 5| 3| 3| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0.3MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Multiple | X X X X X X X | Alveolar/Bronchiolar Carcinoma | X X X | Alveolar/Bronchiolar Carcinoma, | | Multiple | X X | Leukemia Mononuclear | X X X X X X X | Squamous Cell Carcinoma | X X X| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Squamous Cell Carcinoma, Metastatic, | | Lung | X| __________________________________________________________________________| Pleura | +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | | Squamous Cell Carcinoma, Metastatic, | | Lung | X| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Zymbal's Gland | + | Adenoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Squamous Cell Carcinoma, Metastatic, | | Lung | X X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Transitional Epithelium, Papilloma | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 5| 6| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 6| | DAY ON TEST | 2| 3| 5| 2| 7| 7| 3| 5| 3| 3| 3| 7| 3| 8| 3| 0| 3| 3| 3| 0| 2| 3| 3| 2| 5| | | 8| 4| 6| 5| 1| 2| 3| 8| 5| 4| 3| 2| 4| 6| 4| 6| 4| 0| 3| 3| 8| 4| 4| 1| 8| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 0.3MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + A +| 48 | Leukemia Mononuclear | X X X | 3 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + A +| 46 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + A +| 48 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + A + + + A +| 43 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + A +| 44 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cholangiocarcinoma | | 1 | Leukemia Mononuclear | X X X X X X X X X X X X X X| 23 | __________________________________________________________________________|____________| Mesentery | + + + | 8 | Squamous Cell Carcinoma, Metastatic, | | | Lung | | 1 | __________________________________________________________________________|____________| Oral Mucosa | + + | 2 | Pharyngeal, Squamous Cell Papilloma | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 5 | Squamous Cell Carcinoma, Metastatic, | | | Lung | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + A +| 49 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Tooth | +| 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | X | 1 | Leukemia Mononuclear | X X X X X X| 8 | Schwannoma Benign | | 1 | Squamous Cell Carcinoma, Metastatic, | | | Lung | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 5| 6| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 6| | DAY ON TEST | 2| 3| 5| 2| 7| 7| 3| 5| 3| 3| 3| 7| 3| 8| 3| 0| 3| 3| 3| 0| 2| 3| 3| 2| 5| | | 8| 4| 6| 5| 1| 2| 3| 8| 5| 4| 3| 2| 4| 6| 4| 6| 4| 0| 3| 3| 8| 4| 4| 1| 8| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 0.3MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X| 15 | Squamous Cell Carcinoma, Metastatic, | | | Lung | | 1 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X| 15 | Pheochromocytoma Malignant | | 1 | Pheochromocytoma Benign | X X X X X X X X X X | 18 | Squamous Cell Carcinoma, Metastatic, | | | Lung | | 1 | Bilateral, Pheochromocytoma Benign | X X X X| 5 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X| 3 | Carcinoma | X | 3 | Squamous Cell Carcinoma, Metastatic, | | | Lung | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| 45 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X| 8 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X| 30 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + A +| 48 | C-Cell, Adenoma | X X X X X X| 9 | C-Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | Chemodectoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Penis | + | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 2 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + A +| 49 | Leukemia Mononuclear | X X | 4 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X | 17 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 5| 6| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 6| | DAY ON TEST | 2| 3| 5| 2| 7| 7| 3| 5| 3| 3| 3| 7| 3| 8| 3| 0| 3| 3| 3| 0| 2| 3| 3| 2| 5| | | 8| 4| 6| 5| 1| 2| 3| 8| 5| 4| 3| 2| 4| 6| 4| 6| 4| 0| 3| 3| 8| 4| 4| 1| 8| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 0.3MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Interstitial Cell, Adenoma | X X X X X X X | 16 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X| 14 | __________________________________________________________________________|____________| Lymph Node | | 2 | Deep Cervical, Leukemia Mononuclear | | 1 | Iliac, Leukemia Mononuclear | | 1 | Renal, Squamous Cell Carcinoma, | | | Metastatic, Lung | | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | M + + + M + + + + + + M + + + + + + + + + + + + M| 44 | Leukemia Mononuclear | X X X X X X X X X X X | 17 | Squamous Cell Carcinoma, Metastatic, | | | Lung | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + M M + + + + + + M + + + + + + + + + + + + +| 47 | Leukemia Mononuclear | X X X X X X X X X X X X X X X| 22 | Squamous Cell Carcinoma, Metastatic, | | | Lung | | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X X X X| 23 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + M + + + + + + M + + + + + + + + M + + + M| 40 | Leukemia Mononuclear | X X X X X X X X X X X X | 17 | Squamous Cell Carcinoma, Metastatic, | | | Lung | | 2 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + A +| 48 | Leukemia Mononuclear | X X X X X X X X X X X X X X X X| 25 | __________________________________________________________________________|____________| Thymus | + + + + M + + M + + + + + + + + + M + + + + + + +| 45 | Leukemia Mononuclear | X X X X X X X X X | 13 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M + + + M M + + M + + M M + M + M + M M + + + + +| 24 | Carcinoma | | 1 | Fibroadenoma | | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Keratoacanthoma | X | 2 | Leukemia Mononuclear | X X | 2 | Squamous Cell Papilloma | | 1 | Subcutaneous Tissue, Fibroma | X X X | 3 | Subcutaneous Tissue, Fibrosarcoma | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 5| 6| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 6| | DAY ON TEST | 2| 3| 5| 2| 7| 7| 3| 5| 3| 3| 3| 7| 3| 8| 3| 0| 3| 3| 3| 0| 2| 3| 3| 2| 5| | | 8| 4| 6| 5| 1| 2| 3| 8| 5| 4| 3| 2| 4| 6| 4| 6| 4| 0| 3| 3| 8| 4| 4| 1| 8| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 0.3MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | Subcutaneous Tissue, Lipoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteosarcoma | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 3 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X X X X X X X X X | 18 | Alveolar/Bronchiolar Adenoma, | | | Multiple | X X X X X | 12 | Alveolar/Bronchiolar Carcinoma | X X X X X X X X| 11 | Alveolar/Bronchiolar Carcinoma, | | | Multiple | X X X | 5 | Leukemia Mononuclear | X X X X X X X X X X X X X X X| 22 | Squamous Cell Carcinoma | X | 4 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 2 | Squamous Cell Carcinoma, Metastatic, | | | Lung | | 1 | __________________________________________________________________________|____________| Pleura | + | 2 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | X | 1 | Squamous Cell Carcinoma, Metastatic, | | | Lung | | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + A +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | __________________________________________________________________________|____________| Zymbal's Gland | | 1 | Adenoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 88124-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:55:46 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 5| 6| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 6| | DAY ON TEST | 2| 3| 5| 2| 7| 7| 3| 5| 3| 3| 3| 7| 3| 8| 3| 0| 3| 3| 3| 0| 2| 3| 3| 2| 5| | | 8| 4| 6| 5| 1| 2| 3| 8| 5| 4| 3| 2| 4| 6| 4| 6| 4| 0| 3| 3| 8| 4| 4| 1| 8| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 0.3MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Leukemia Mononuclear | X X X X X X X X X X X X| 16 | Squamous Cell Carcinoma, Metastatic, | | | Lung | | 2 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | Transitional Epithelium, Papilloma | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X X X X| 25 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------ --multipart-boundary Content-type: text/plain Range: bytes 589572-589572/589572 --multipart-boundary--