TDMS Study 88124-03 Pathology Tables
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
FINAL#1 CORE STUDY RATS
Facility: Battelle Northwest
Chemical CAS #: 22398-80-7
Lock Date: 09/25/98
Cage Range: All
Reasons For Removal: 25022 Accidently Killed 25019 Moribund Sacrifice
25020 Natural Death 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 7| 7| 7| 1| 7| 6| 7| 3| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5| 5|
DAY ON TEST | 3| 3| 3| 3| 8| 1| 3| 3| 3| 2| 3| 6| 3| 9| 3| 3| 5| 3| 3| 3| 3| 6| 3| 6| 0|
| 7| 5| 7| 7| 4| 5| 6| 7| 6| 4| 6| 7| 6| 7| 7| 6| 0| 6| 5| 7| 5| 9| 7| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + A + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X |
Eosinophilic Focus | X |
Fatty Change | 2 2 1 1 |
Hepatodiaphragmatic Nodule | X X X X |
Inflammation, Granulomatous | 2 |
Mixed Cell Focus | X X X |
Regeneration | 2 |
Vacuolization Cytoplasmic, Focal | 2 1 |
Bile Duct, Hyperplasia | 2 2 1|
Centrilobular, Necrosis | 2 1|
__________________________________________________________________________|
Mesentery | + + + +|
Fat, Necrosis | 3 3 3 2|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 3 2 |
Basophilic Focus | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Basophilic Focus | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + A + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Tongue | |
Hyperplasia, Squamous | |
__________________________________________________________________________|
Tooth | + + |
Inflammation, Chronic Active | 4 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 2 2 2 1 2 2 2 1 1 2 2 1 2 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + A + + + + + + + +|
Degeneration, Cystic | 3 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 7| 7| 7| 1| 7| 6| 7| 3| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5| 5|
DAY ON TEST | 3| 3| 3| 3| 8| 1| 3| 3| 3| 2| 3| 6| 3| 9| 3| 3| 5| 3| 3| 3| 3| 6| 3| 6| 0|
| 7| 5| 7| 7| 4| 5| 6| 7| 6| 4| 6| 7| 6| 7| 7| 6| 0| 6| 5| 7| 5| 9| 7| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 2 2 2 3 1 2 2 1 2 |
Hypertrophy | 1 2 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + M + M + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Pars Distalis, Angiectasis | 4 |
Pars Distalis, Hyperplasia | 4 3 3 1 4 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + A + + A + + + + + + + +|
C-Cell, Hyperplasia | 2 3 3 2 2 1 2 2 3 2 3 2 2 2 2 3 2 3 1 1|
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 4 1 3 |
Inflammation, Granulomatous | |
Interstitial Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cervix, Hypertrophy | |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + A + + + + + + + +|
Inflammation, Granulomatous | |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M M M + M M M M M M + + + + M M + + M M M M +|
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + M + + + M + + + + + M + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M M M + M M M + M M + + + + + + + + + M + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | |
__________________________________________________________________________|
Thymus | + + + M + M + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 7| 7| 7| 1| 7| 6| 7| 3| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5| 5|
DAY ON TEST | 3| 3| 3| 3| 8| 1| 3| 3| 3| 2| 3| 6| 3| 9| 3| 3| 5| 3| 3| 3| 3| 6| 3| 6| 0|
| 7| 5| 7| 7| 4| 5| 6| 7| 6| 4| 6| 7| 6| 7| 7| 6| 0| 6| 5| 7| 5| 9| 7| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 3 3 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epiglottis, Metaplasia, Squamous | 2 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Chronic Active | 1 1 1 |
Thrombosis | 3 1 |
Alveolar Epithelium, Hyperplasia | 1 1 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 1 1 |
Bronchiole, Inflammation, Suppurative| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 2 2 |
Thrombosis | 1|
Olfactory Epithelium, Metaplasia | 2 |
Respiratory Epithelium, Hyperplasia | 3 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 4 |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 1 1 2 2 1 2 1 1 2 1 2 2 1 2 1 2 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 6| 3| 2| 3| 5| 7| 3| 3| 3| 3| 9| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| |
| 7| 5| 6| 7| 1| 6| 7| 7| 5| 5| 0| 5| 1| 6| 6| 6| 6| 6| 7| 6| 7| 7| 5| 7| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X X| 46 |
Clear Cell Focus | X X X X X X X X X X X | 17 |
Eosinophilic Focus | X | 2 |
Fatty Change | | 4 1.5|
Hepatodiaphragmatic Nodule | X X X | 7 |
Inflammation, Granulomatous | | 1 2.0|
Mixed Cell Focus | X X X | 6 |
Regeneration | | 1 2.0|
Vacuolization Cytoplasmic, Focal | 2 1 | 4 1.5|
Bile Duct, Hyperplasia | 1 | 4 1.5|
Centrilobular, Necrosis | 1 | 3 1.3|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 9 |
Fat, Necrosis | 3 3 2 3 2 | 9 2.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 | 5 2.2|
Basophilic Focus | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 2 | 3 2.7|
Basophilic Focus | X X | 3 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | 1 | 2 1.5|
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
Hyperplasia, Squamous | 1 | 1 1.0|
__________________________________________________________________________|____________|
Tooth | | 2 |
Inflammation, Chronic Active | | 2 3.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 6| 3| 2| 3| 5| 7| 3| 3| 3| 3| 9| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| |
| 7| 5| 6| 7| 1| 6| 7| 7| 5| 5| 0| 5| 1| 6| 6| 6| 6| 6| 7| 6| 7| 7| 5| 7| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Cardiomyopathy | 2 1 2 1 1 2 1 2 2 2 2 1 2 1 1 2 2 2 2 1 1| 37 1.6|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Cystic | 2 | 3 2.3|
Hyperplasia | 2 1 2 2 2 2 2 3 1 2 2 2 | 21 1.9|
Hypertrophy | 2 3 2 3 2 1 3 2 4 | 11 2.3|
Vacuolization Cytoplasmic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 | 6 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + I M + + + + + + M + + M + M + + + + + + + M +| 40 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 1 2.0|
Pars Distalis, Angiectasis | | 1 4.0|
Pars Distalis, Hyperplasia | 4 4 4 3 2 4 4 4 3 | 15 3.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 47 |
C-Cell, Hyperplasia | 2 2 2 3 2 1 1 2 2 3 2 1 2 2 2 2 2 2 1 2 3| 41 2.0|
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Hyperplasia | 3 3 2 | 5 2.8|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 3 2 2 4 | 9 2.6|
Inflammation, Granulomatous | 3 2 | 2 2.5|
Interstitial Cell, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cervix, Hypertrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Granulomatous | 1 | 1 1.0|
Myelofibrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 6| 3| 2| 3| 5| 7| 3| 3| 3| 3| 9| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| |
| 7| 5| 6| 7| 1| 6| 7| 7| 5| 5| 0| 5| 1| 6| 6| 6| 6| 6| 7| 6| 7| 7| 5| 7| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + M + M M M M M + + M M M + + + + + M +| 25 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M M + + + + M + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + M M M + M M M M + M M + + M + + M +| 28 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + + + + + + + + + + M M + + +| 45 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteopetrosis | 2 2 3 | 6 2.3|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epiglottis, Metaplasia, Squamous | 4 | 3 2.7|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X | 1 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 | 10 1.0|
Thrombosis | | 2 2.0|
Alveolar Epithelium, Hyperplasia | 2 3 1 1 1 | 8 1.5|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 | 16 1.0|
Bronchiole, Inflammation, Suppurative| 4 | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 1 | 6 1.8|
Thrombosis | 3 | 2 2.0|
Olfactory Epithelium, Metaplasia | | 1 2.0|
Respiratory Epithelium, Hyperplasia | | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 6| 3| 2| 3| 5| 7| 3| 3| 3| 3| 9| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| |
| 7| 5| 6| 7| 1| 6| 7| 7| 5| 5| 0| 5| 1| 6| 6| 6| 6| 6| 7| 6| 7| 7| 5| 7| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cataract | | 1 4.0|
Retina, Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy | 1 2 2 1 1 1 1 2 2 1 2 2 2 1 2 2 1 2 2 3 3 2| 41 1.6|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
_____________________________________________________________________________________________________________________
| 7| 1| 5| 7| 7| 6| 7| 4| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 2| 2| 6| 3| 3| 0| 3| 8| 3| 8| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 8| 8| 3| 3| 3|
| 8| 0| 0| 6| 6| 7| 5| 1| 7| 6| 7| 5| 1| 7| 5| 7| 5| 7| 6| 6| 4| 3| 6| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.03 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + A + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X |
Eosinophilic Focus | X X X|
Fatty Change | 2 |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Granulomatous | 3 |
Necrosis | 2 2 2 |
Regeneration | 2 |
Vacuolization Cytoplasmic, Focal | |
Bile Duct, Hyperplasia | 2 2 4 3 1 |
Centrilobular, Necrosis | 2 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + +|
Fat, Necrosis | 3 2 3 3 3 3 2 2|
__________________________________________________________________________|
Oral Mucosa | + |
Pharyngeal, Hyperplasia | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 3 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | |
Inflammation, Acute | |
Ulcer | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 1 2|
__________________________________________________________________________|
Tongue | + |
Hyperplasia, Squamous | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 1 2 1 2 1 1 2 2 1 1 2 |
Atrium, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + A + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
_____________________________________________________________________________________________________________________
| 7| 1| 5| 7| 7| 6| 7| 4| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 2| 2| 6| 3| 3| 0| 3| 8| 3| 8| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 8| 8| 3| 3| 3|
| 8| 0| 0| 6| 6| 7| 5| 1| 7| 6| 7| 5| 1| 7| 5| 7| 5| 7| 6| 6| 4| 3| 6| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.03 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Degeneration, Cystic | 3 |
Hyperplasia | 2 3 3 2 1 2 2 2 2 2 2|
Hypertrophy | 2 2 2 2 2 |
Necrosis | 2 3 2 |
Thrombosis | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + A + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | M M + M M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Hyperplasia | 3 2 2 4 4 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + A + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 2 3 1 2 3 2 2 2 2 2 1 1 2 2 2 1 2 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 2 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Bronchial | M M + M M + M M M + M M M M + M M M M + M M + + +|
Foreign Body | 3 1 2 1 3 3|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + A + M M + M + M + M M + M + M M + M + + M + + +|
Foreign Body | 3 3 3 3 3 3 3 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 2 3 2|
Hemorrhage | 3 |
Necrosis | 2 |
__________________________________________________________________________|
Thymus | + A + + + + + + + + + + + + M + + + M + + + + + +|
Atrophy | |
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
_____________________________________________________________________________________________________________________
| 7| 1| 5| 7| 7| 6| 7| 4| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 2| 2| 6| 3| 3| 0| 3| 8| 3| 8| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 8| 8| 3| 3| 3|
| 8| 0| 0| 6| 6| 7| 5| 1| 7| 6| 7| 5| 1| 7| 5| 7| 5| 7| 6| 6| 4| 3| 6| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.03 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 |
Inflammation, Acute | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 3 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + A + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2|
Epiglottis, Metaplasia, Squamous | |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Squamous | 4 |
Foreign Body | 2 1 2 2 2 2 3 2 3 2 2 2 2 2 2 2 2 2 2 1 2 3 2 2 2|
Hyperplasia, Atypical | 2 2 4 4 |
Inflammation, Chronic Active | 3 1 3 3 3 3 4 3 3 3 2 4 4 3 3 3 4 3 2 3 2 3 3 3 2|
Metaplasia, Squamous | |
Alveolar Epithelium, Hyperplasia | 2 4 2 2 2 2 2 2 2|
Alveolar Epithelium, Metaplasia | 3 3 4 4 4 3 4 2 3 4 3 4 4 3 4 4 3 3 3 4 3 2|
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Alveolus, Proteinosis | 3 3 3 4 4 4 4 3 4 2 4 4 4 4 4 3 4 4 4 2 4 4 4 3 4|
Interstitium, Fibrosis | 3 2 3 3 2 4 3 3 2 2 4 3 3 4 3 4 3 2 3 2 2 3 3 3|
Mediastinum, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 2 2 3 2 |
Thrombosis | 2 4 |
Lateral Wall, Metaplasia, Squamous | |
Olfactory Epithelium, Metaplasia | 2 1 |
Respiratory Epithelium, Hyperplasia | 2 3 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 |
__________________________________________________________________________|
Trachea | + + + + + A + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
_____________________________________________________________________________________________________________________
| 7| 1| 5| 7| 7| 6| 7| 4| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 2| 2| 6| 3| 3| 0| 3| 8| 3| 8| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 8| 8| 3| 3| 3|
| 8| 0| 0| 6| 6| 7| 5| 1| 7| 6| 7| 5| 1| 7| 5| 7| 5| 7| 6| 6| 4| 3| 6| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.03 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | |
Nephropathy | 1 1 1 2 1 1 2 1 2 2 1 2 1 2 2 1 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 0| 5| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 1| 3| 2| 8| 3| 9| 3| 3| 3| 3| 9| 3| 1| 9| 3| 2| 9| 3| 3| 3| 3| 2| 3| 3| |
| 5| 4| 6| 8| 0| 6| 5| 5| 7| 7| 6| 4| 5| 4| 5| 7| 6| 7| 7| 6| 6| 5| 5| 6| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0.03 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + I + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + + A + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + A + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 2 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X| 39 |
Clear Cell Focus | X X X X X | 8 |
Eosinophilic Focus | X X | 5 |
Fatty Change | 3 | 2 2.5|
Hepatodiaphragmatic Nodule | X | 4 |
Inflammation, Granulomatous | 3 | 2 3.0|
Necrosis | | 3 2.0|
Regeneration | 3 | 2 2.5|
Vacuolization Cytoplasmic, Focal | 2 | 1 2.0|
Bile Duct, Hyperplasia | 2 2 3| 8 2.4|
Centrilobular, Necrosis | 2 1 2 2 | 7 1.9|
__________________________________________________________________________|____________|
Mesentery | + + + + + + +| 15 |
Fat, Necrosis | 3 2 2 2 2 2 3| 15 2.5|
__________________________________________________________________________|____________|
Oral Mucosa | + | 2 |
Pharyngeal, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 2 1 1 1 2 2 1 | 12 1.4|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | 3 | 1 3.0|
Inflammation, Acute | 2 | 1 2.0|
Ulcer | 3 | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 3 2 | 5 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
Hyperplasia, Squamous | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 0| 5| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 1| 3| 2| 8| 3| 9| 3| 3| 3| 3| 9| 3| 1| 9| 3| 2| 9| 3| 3| 3| 3| 2| 3| 3| |
| 5| 4| 6| 8| 0| 6| 5| 5| 7| 7| 6| 4| 5| 4| 5| 7| 6| 7| 7| 6| 6| 5| 5| 6| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0.03 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Cardiomyopathy | 1 1 2 2 1 1 2 1 1 2 2 1 2 1 2 | 29 1.4|
Atrium, Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Cystic | 2 2 | 3 2.3|
Hyperplasia | 2 1 1 2 2 2 2 2 2 2 2 2 | 23 2.0|
Hypertrophy | 2 3 2 1 4 1 2 2| 13 2.1|
Necrosis | 2 | 4 2.3|
Thrombosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + I + + + + + + +| 48 |
Hyperplasia | 2 2 1 2 3 2 2 2 3| 13 2.2|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + + + M + M + + M + + + + + + +| 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 2 | 2 2.5|
Pars Distalis, Hyperplasia | 2 3 3 3 3 2 1 3 3| 15 2.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + A + + + + + + + + + + A + +| 47 |
C-Cell, Hyperplasia | 3 3 3 1 2 2 1 3 3 2 2 2 2 2 2 4 2 2 2 2 2| 42 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + M + + + + + + + + + + + + + + M + +| 47 |
Cyst | 2 | 1 2.0|
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 3 | 6 2.2|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + +| 5 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + M M + + + + + + M + + + + + + + + + +| 30 |
Foreign Body | 3 3 3 3 3 2 2 3 3 3 3 3 3 2 2 3 3| 23 2.6|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + + + + + +| 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 0| 5| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 1| 3| 2| 8| 3| 9| 3| 3| 3| 3| 9| 3| 1| 9| 3| 2| 9| 3| 3| 3| 3| 2| 3| 3| |
| 5| 4| 6| 8| 0| 6| 5| 5| 7| 7| 6| 4| 5| 4| 5| 7| 6| 7| 7| 6| 6| 5| 5| 6| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0.03 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + M + + + + + + + M + + + + + + + + + +| 36 |
Foreign Body | 3 3 3 3 4 3 3 | 15 3.1|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | | 3 2.3|
Hemorrhage | 2 | 2 2.5|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Atrophy | 2 | 1 2.0|
Epithelial Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 2 | 4 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + I + +| 49 |
Hyperkeratosis | 4 | 2 3.5|
Inflammation, Acute | 3 | 1 3.0|
Inflammation, Chronic Active | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteopetrosis | 3 3 2 2 2 | 7 2.6|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Acute | | 1 2.0|
Epiglottis, Metaplasia, Squamous | 2 1 | 2 1.5|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 1 1 2 | 5 1.4|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst, Squamous | | 1 4.0|
Foreign Body | 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 3 2 2 2 3 3 2 3 2| 49 2.1|
Hyperplasia, Atypical | 2 2 3 3 | 8 2.8|
Inflammation, Chronic Active | 3 4 4 2 2 3 3 4 3 3 3 3 4 3 3 4 3 3 4 3 3 3 3 3| 49 3.0|
Metaplasia, Squamous | 2 1 | 2 1.5|
Alveolar Epithelium, Hyperplasia | 2 2 2 1 1 4 | 15 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 0| 5| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 1| 3| 2| 8| 3| 9| 3| 3| 3| 3| 9| 3| 1| 9| 3| 2| 9| 3| 3| 3| 3| 2| 3| 3| |
| 5| 4| 6| 8| 0| 6| 5| 5| 7| 7| 6| 4| 5| 4| 5| 7| 6| 7| 7| 6| 6| 5| 5| 6| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0.03 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar Epithelium, Metaplasia | 4 3 4 1 1 3 3 4 4 3 1 3 4 4 4 4 3 4 4 4 4 3 4 4| 46 3.3|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 | 1 1.0|
Alveolus, Proteinosis | 4 4 4 4 4 4 3 4 4 4 4 3 4 3 2 4 3 4 4 4 4 4 4 4| 49 3.7|
Interstitium, Fibrosis | 3 4 4 2 2 2 3 3 3 2 2 3 3 3 3 4 2 3 4 4 4 3 3 3| 48 2.9|
Mediastinum, Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 3 2| 8 2.4|
Thrombosis | 2 | 3 2.7|
Lateral Wall, Metaplasia, Squamous | 2 1 | 2 1.5|
Olfactory Epithelium, Metaplasia | 2 2 | 4 1.8|
Respiratory Epithelium, Hyperplasia | 3 3 | 4 2.8|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 2| 3 1.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
Accumulation, Hyaline Droplet | 3 | 1 3.0|
Nephropathy | 1 1 1 2 2 1 1 1 1 3 2 1 3 2 2 2 2 2 3 1| 38 1.6|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + I + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 6| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 6| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 4| 3| 3| 3| 1| 0| 1| 5| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 7| 8| 8|
| 6| 6| 6| 7| 8| 5| 7| 6| 4| 0| 6| 6| 5| 7| 6| 7| 6| 6| 2| 7| 6| 6| 9| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.1MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X X |
Eosinophilic Focus | |
Fatty Change | 2 2 2 |
Hepatodiaphragmatic Nodule | |
Inflammation, Chronic Active | 1 |
Mixed Cell Focus | X |
Bile Duct, Hyperplasia | 2 2 2 |
Centrilobular, Necrosis | 2 1 |
Periportal, Infiltration Cellular, | |
Mononuclear Cell | |
Serosa, Hemorrhage | |
__________________________________________________________________________|
Mesentery | + + + + + + + |
Fat, Necrosis | 2 2 2 2 3 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 4 |
Basophilic Focus | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 3 |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 2 1 1 1 2 2 2 1 1 1 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 |
Hyperplasia | 3 2 2 1 2 3 2 2 1 1 2 1 2 1 2|
Hypertrophy | 3 2 |
Vacuolization Cytoplasmic | 3 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 6| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 6| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 4| 3| 3| 3| 1| 0| 1| 5| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 7| 8| 8|
| 6| 6| 6| 7| 8| 5| 7| 6| 4| 0| 6| 6| 5| 7| 6| 7| 6| 6| 2| 7| 6| 6| 9| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.1MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + M + + + + M M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 |
Pars Distalis, Hyperplasia | 3 3 2 4 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 1 3 2 2 1 2 2 2 2 2 3 1 2 1 3 2 2 2 2 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Acute | 4 |
Ulcer | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Bronchial | M M M M M M + + + + + + + + M + + + + + + + M + M|
Foreign Body | 3 3 3 3 3 3 3 3 2 3 1 3 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + M + + + + + + + +|
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M M + M + + + + + + + + + + + + + M + + M M M|
Foreign Body | 2 2 1 3 3 3 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 3 |
Hemorrhage | 2 |
Metaplasia, Osseous | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 6| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 6| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 4| 3| 3| 3| 1| 0| 1| 5| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 7| 8| 8|
| 6| 6| 6| 7| 8| 5| 7| 6| 4| 0| 6| 6| 5| 7| 6| 7| 6| 6| 2| 7| 6| 6| 9| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.1MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Galactocele | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 3 4 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epiglottis, Metaplasia, Squamous | 3 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 3 1 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Squamous | |
Foreign Body | 2 1 1 1 1 1 2 1 2 2 2 1 3 2 1 2 2 2 2 2 2 2 2 2 2|
Hyperplasia, Atypical | 3 3 1 4|
Inflammation, Chronic Active | 2 2 2 2 3 2 2 2 2 2 3 3 2 3 2 3 2 3 3 2 2 3 2 3 3|
Metaplasia, Squamous | |
Alveolar Epithelium, Hyperplasia | 2 2 2 4 1 1 3 1 3 |
Alveolar Epithelium, Metaplasia | 2 4 3 4 1 2 3 2 1 1 2 3 4 1 4 1 2 3 1 3 2 2 4|
Alveolus, Proteinosis | 2 1 2 1 2 1 3 2 3 2 2 2 2 3 2 2 1 2 2 2 2 2 2|
Interstitium, Fibrosis | 2 3 3 3 2 2 2 2 2 2 3 3 2 3 2 3 2 3 3 2 2 3 2 2 3|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 2 2 |
Thrombosis | 1 |
Olfactory Epithelium, Metaplasia | |
Respiratory Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 4 |
Retina, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 2 2 1 1 1 2 2 1 2 1 2 2 2 2 2 2 2 2 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 8| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 6| 3| 3| 3| 3| 3| |
| 7| 5| 6| 7| 5| 6| 5| 6| 6| 7| 7| 7| 6| 5| 5| 7| 7| 5| 7| 6| 6| 5| 7| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
0.1MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X| 47 |
Clear Cell Focus | X X X X X X X X | 17 |
Eosinophilic Focus | X X X | 3 |
Fatty Change | 2 | 4 2.0|
Hepatodiaphragmatic Nodule | X X | 2 |
Inflammation, Chronic Active | | 1 1.0|
Mixed Cell Focus | X X X| 4 |
Bile Duct, Hyperplasia | 2 | 4 2.0|
Centrilobular, Necrosis | 2 | 3 1.7|
Periportal, Infiltration Cellular, | | |
Mononuclear Cell | 3 | 1 3.0|
Serosa, Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + | 15 |
Fat, Necrosis | 3 2 2 2 2 2 2 3 | 15 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 3 2 | 6 2.2|
Basophilic Focus | X | 3 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 3 2 1 1 1 3 2 1 1 2 2 1 1 1 1 1 2 2 2 2 1| 41 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 8| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 6| 3| 3| 3| 3| 3| |
| 7| 5| 6| 7| 5| 6| 5| 6| 6| 7| 7| 7| 6| 5| 5| 7| 7| 5| 7| 6| 6| 5| 7| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
0.1MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 3 | 2 3.0|
Hyperplasia | 2 2 1 2 2 2 2 2 2 2 2 3| 27 1.9|
Hypertrophy | 1 | 3 2.0|
Vacuolization Cytoplasmic | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 1 3 3 | 9 2.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M M + + + + + + + + + + + + + + + + M + +| 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + I + + + + + + + + + + M + + + +| 48 |
Pars Distalis, Angiectasis | 1 | 3 1.7|
Pars Distalis, Hyperplasia | 3 2 4 3 3 1 3 2 | 13 2.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 1 2 3 3 3 | 42 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M + + + + + + + + + + + + + + + + + M + + + + +| 47 |
Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 2 3 3 | 7 2.9|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 1 3.0|
Inflammation, Acute | | 1 4.0|
Ulcer | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + M + + + + M + + + + + + M + + + M M + + + +| 35 |
Foreign Body | 2 2 3 3 3 3 4 3 2 3 2 3 3| 26 2.8|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M M + + M + M + + + + + + M + + M + + + + + + +| 42 |
Infiltration Cellular, Plasma Cell | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + M + + + + + + + + + + + + + + M + + + +| 39 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 8| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 6| 3| 3| 3| 3| 3| |
| 7| 5| 6| 7| 5| 6| 5| 6| 6| 7| 7| 7| 6| 5| 5| 7| 7| 5| 7| 6| 6| 5| 7| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
0.1MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Foreign Body | 3 2 3 2 2 1 3 2 2 3 1| 18 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 3 3 2 2 2 | 6 2.5|
Hemorrhage | | 1 2.0|
Metaplasia, Osseous | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteopetrosis | 3 3 3 3 | 6 3.2|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epiglottis, Metaplasia, Squamous | | 1 3.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 3 | 4 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst, Squamous | 4 | 1 4.0|
Foreign Body | 2 2 2 1 2 1 1 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 50 1.8|
Hyperplasia, Atypical | 4 2 4 2 | 8 2.9|
Inflammation, Chronic Active | 3 3 2 3 3 3 3 3 2 2 3 3 3 3 3 3 3 2 3 3 3 3 3 3 3| 50 2.6|
Metaplasia, Squamous | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 3 2 1 3 1 2 2 4 2 2 1 1 1| 22 2.0|
Alveolar Epithelium, Metaplasia | 3 2 2 2 2 2 2 2 2 3 2 3 1 2 4 3 2 3 2 3 4 2 1 2| 47 2.4|
Alveolus, Proteinosis | 2 2 2 1 2 2 2 2 1 2 2 2 2 3 2 2 4 2 3 2 2 2 2 2| 47 2.0|
Interstitium, Fibrosis | 3 3 2 3 3 3 2 3 2 3 3 3 3 3 3 2 3 2 3 3 2 3 2 2 3| 50 2.6|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 8| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 6| 3| 3| 3| 3| 3| |
| 7| 5| 6| 7| 5| 6| 5| 6| 6| 7| 7| 7| 6| 5| 5| 7| 7| 5| 7| 6| 6| 5| 7| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
0.1MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Thrombosis | | 1 1.0|
Olfactory Epithelium, Metaplasia | 1 | 1 1.0|
Respiratory Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 3 |
Cataract | 3 3 | 3 3.3|
Retina, Atrophy | 3 3 | 3 3.3|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy | 1 1 1 1 2 1 2 2 2 2 2 2 2 1 2 2 2 2 2 2 1 2| 42 1.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 6| 5| 1| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5|
DAY ON TEST | 3| 9| 3| 3| 1| 3| 3| 3| 3| 1| 2| 5| 8| 8| 3| 3| 4| 3| 3| 3| 3| 5| 3| 3| 3|
| 6| 3| 7| 7| 3| 5| 6| 6| 6| 9| 6| 6| 8| 6| 6| 5| 3| 5| 7| 5| 5| 6| 7| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.3MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + A + + A + + + + + + + + + + M|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + A + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + A + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + A + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X |
Eosinophilic Focus | X X |
Fatty Change | |
Hepatodiaphragmatic Nodule | X X X X X X X |
Inflammation, Granulomatous | 3 |
Mixed Cell Focus | X X X X |
Necrosis | 2 |
Regeneration | 2 2 |
Tension Lipidosis | |
Thrombosis | 3 |
Vacuolization Cytoplasmic, Focal | |
Bile Duct, Hyperplasia | 2 2 3 1 2 3 2 |
Centrilobular, Necrosis | 1 1 1 1 2|
__________________________________________________________________________|
Mesentery | + + + + + + + |
Fat, Necrosis | 2 2 3 2 2 2 |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + A + + + + + + + + + + +|
Atrophy | 1 |
Basophilic Focus | |
Metaplasia, Hepatocyte | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Basophilic Focus | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + A + + + + + + + + + + +|
Hyperplasia, Squamous | |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + A + + + + + + + + + + +|
Necrosis | 3 |
__________________________________________________________________________|
Tongue | + |
Hyperplasia, Squamous | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 1 2 2 2 2 1 1 1 2 1 1 2 1|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 6| 5| 1| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5|
DAY ON TEST | 3| 9| 3| 3| 1| 3| 3| 3| 3| 1| 2| 5| 8| 8| 3| 3| 4| 3| 3| 3| 3| 5| 3| 3| 3|
| 6| 3| 7| 7| 3| 5| 6| 6| 6| 9| 6| 6| 8| 6| 6| 5| 3| 5| 7| 5| 5| 6| 7| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.3MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + A + + + + + + + + + + +|
Atrophy | 2 3 |
Degeneration, Cystic | 2 |
Hyperplasia | 1 1 2 1 2 2 2 1 2 3 1 |
Hypertrophy | 2 1 |
Necrosis | 4|
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + A + + + + + + + + + + +|
Hyperplasia | 2 4 1 2 |
Necrosis | 4|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + A + + + M + M M + M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + A + + + + + + + + + + +|
Cyst | 1 3 |
Hemorrhage, Chronic | 4 |
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Hyperplasia | 4 3 3 3 3 2 4 2 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + A + + + + + M + + + + +|
C-Cell, Hyperplasia | 2 1 2 4 3 2 2 2 3 1 2 3 2 2 1 3 3 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + A + + + + + + + + + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + A + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + A + + + + + + + + + + +|
Cyst | 2 |
Inflammation, Acute | 3|
Thrombosis | 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + A + + A + + + + + + + + + + +|
Inflammation, Granulomatous | 2 |
Myelofibrosis | 1 |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M + + + + + M M + + + M + + + M + + + + M|
Foreign Body | 2 3 4 3 3 2 3 4 3 4 3 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + M M|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 6| 5| 1| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5|
DAY ON TEST | 3| 9| 3| 3| 1| 3| 3| 3| 3| 1| 2| 5| 8| 8| 3| 3| 4| 3| 3| 3| 3| 5| 3| 3| 3|
| 6| 3| 7| 7| 3| 5| 6| 6| 6| 9| 6| 6| 8| 6| 6| 5| 3| 5| 7| 5| 5| 6| 7| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.3MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + A + + A + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + M + + + + + + + + + + + + M + M + M M M + M M|
Foreign Body | 3 3 3 3 3 3 2 3 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + A + + A + + + + + + + + + + +|
Fibrosis | 3 3 |
Hematopoietic Cell Proliferation | 3|
Hemorrhage | |
__________________________________________________________________________|
Thymus | + M + + + + + + + + M + + A + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 2 |
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2|
Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + A + + + + + + + + + + +|
Osteopetrosis | 3 3 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + A + + + + + + + + + + +|
Inflammation, Acute | 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 2 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Squamous | 4 4 4 2 4 3 |
Foreign Body | 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2|
Hyperplasia, Atypical | 4 4 4 4 4 3 4 2 4 4 4 4 4 2 2 4 4 |
Inflammation, Chronic Active | 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4|
Metaplasia, Squamous | 3 |
Alveolar Epithelium, Hyperplasia | 2 2 2 2 1 3 |
Alveolar Epithelium, Metaplasia | 4 4 4 4 4 4 4 4 4 4 3 4 4 4 4 4 4 4 4 4 4 4 2|
Alveolus, Proteinosis | 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 3 4 4 4 4 2 4 4 3|
Interstitium, Fibrosis | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + A + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 2 2 |
Thrombosis | 1 3 3 |
Glands, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 6| 5| 1| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5|
DAY ON TEST | 3| 9| 3| 3| 1| 3| 3| 3| 3| 1| 2| 5| 8| 8| 3| 3| 4| 3| 3| 3| 3| 5| 3| 3| 3|
| 6| 3| 7| 7| 3| 5| 6| 6| 6| 9| 6| 6| 8| 6| 6| 5| 3| 5| 7| 5| 5| 6| 7| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.3MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Olfactory Epithelium, Metaplasia | 2 |
Respiratory Epithelium, Hyperplasia | 1 1 2 2 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + A + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 4 |
Retina, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + A + + A + + + + + + + + + + +|
Infarct | 2 |
Nephropathy | 2 2 2 2 2 1 1 1 2 2 2 2 1 1 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + A + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| |
DAY ON TEST | 3| 8| 3| 3| 3| 3| 1| 2| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 5| |
| 7| 5| 6| 7| 5| 7| 1| 7| 7| 6| 6| 0| 6| 7| 6| 6| 7| 5| 6| 7| 6| 5| 8| 7| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
0.3MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + A| 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + A| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + A| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 4.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X| 44 |
Clear Cell Focus | X X X X | 9 |
Eosinophilic Focus | X X X | 5 |
Fatty Change | 3 2 1 | 3 2.0|
Hepatodiaphragmatic Nodule | X X X X | 11 |
Inflammation, Granulomatous | | 1 3.0|
Mixed Cell Focus | | 4 |
Necrosis | 2 2 | 3 2.0|
Regeneration | 4 2 | 4 2.5|
Tension Lipidosis | X | 1 |
Thrombosis | | 1 3.0|
Vacuolization Cytoplasmic, Focal | 2 | 1 2.0|
Bile Duct, Hyperplasia | 2 2 2 | 10 2.1|
Centrilobular, Necrosis | 2 2 1 1 | 9 1.3|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + +| 19 |
Fat, Necrosis | 2 3 2 2 2 2 3 3 3 2 2 2| 18 2.3|
__________________________________________________________________________|____________|
Oral Mucosa | + | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 1 1 2 2 1 2 4 | 8 1.8|
Basophilic Focus | X | 1 |
Metaplasia, Hepatocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 2 2.0|
Basophilic Focus | X X | 2 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Squamous | 4 1 | 2 2.5|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + A| 48 |
Necrosis | 3 | 2 3.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| |
DAY ON TEST | 3| 8| 3| 3| 3| 3| 1| 2| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 5| |
| 7| 5| 6| 7| 5| 7| 1| 7| 7| 6| 6| 0| 6| 7| 6| 6| 7| 5| 6| 7| 6| 5| 8| 7| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
0.3MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Squamous | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 1 1 1 2 2 1 1 2 1 1 1 2 | 30 1.4|
Atrium, Thrombosis | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | | 2 2.5|
Degeneration, Cystic | 3 | 2 2.5|
Hyperplasia | 2 2 2 2 2 2 2 2 2 1 2 2 2 2 | 25 1.8|
Hypertrophy | 1 2 2 2 | 6 1.7|
Necrosis | 4 3 | 3 3.7|
Vacuolization Cytoplasmic | 3 3 2 2 | 4 2.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 2 2 3 1 1 3 3 2 2 1 | 15 2.1|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + + + + M + + + + + I + + M + +| 39 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 2 2.0|
Hemorrhage, Chronic | | 1 4.0|
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Hyperplasia | 3 2 2 2 2 3 2 | 17 2.6|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + A| 47 |
C-Cell, Hyperplasia | 2 2 2 3 1 3 3 2 2 2 2 2 2 2 2 1 1 2 3 1 1 | 39 2.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 | 4 1.8|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 2 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 1 2.0|
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| |
DAY ON TEST | 3| 8| 3| 3| 3| 3| 1| 2| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 5| |
| 7| 5| 6| 7| 5| 7| 1| 7| 7| 6| 6| 0| 6| 7| 6| 6| 7| 5| 6| 7| 6| 5| 8| 7| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
0.3MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Granulomatous | | 1 2.0|
Myelofibrosis | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + M M + + M + + M M + M M M M + M M I + M +| 30 |
Foreign Body | 2 3 2 3 4 3 4| 20 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + M + + + + + + + + M + M + + M + + M + + + +| 42 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + A| 47 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + + + M + M M M + + M + M M M M M M M M + M M| 26 |
Foreign Body | 3 3 2 4 | 13 2.8|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + A| 47 |
Fibrosis | 2 2 | 4 2.5|
Hematopoietic Cell Proliferation | 4 | 2 3.5|
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + + + + + + + + + + + M + + + +| 45 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 2 2 2 2 | 5 2.0|
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + I + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | | 1 2.0|
Inflammation, Acute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Osteopetrosis | 3 4 2 4 | 7 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Acute | | 1 1.0|
Respiratory Epithelium, Metaplasia, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| |
DAY ON TEST | 3| 8| 3| 3| 3| 3| 1| 2| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 5| |
| 7| 5| 6| 7| 5| 7| 1| 7| 7| 6| 6| 0| 6| 7| 6| 6| 7| 5| 6| 7| 6| 5| 8| 7| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
0.3MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Squamous | 2 2 1 | 6 1.8|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst, Squamous | 4 4 3 4 | 10 3.6|
Foreign Body | 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 50 2.0|
Hyperplasia, Atypical | 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4| 39 3.8|
Inflammation, Chronic Active | 4 3 4 3 4 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4| 49 3.9|
Metaplasia, Squamous | 3 2 2 | 4 2.5|
Alveolar Epithelium, Hyperplasia | 2 1 3 1 2 1 1 2 2 2 | 16 1.8|
Alveolar Epithelium, Metaplasia | 4 2 4 4 4 4 3 2 4 4 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4| 48 3.8|
Alveolus, Proteinosis | 4 2 4 4 4 4 4 4 4 4 4 4 4 4 1 4 4 4 4 4 4 4 4 4 4| 50 3.8|
Interstitium, Fibrosis | 4 3 4 4 4 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 3 4 4| 49 3.9|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 2 2 1 1 3| 9 1.9|
Thrombosis | 4 4 2 | 6 2.8|
Glands, Hyperplasia | | 1 3.0|
Olfactory Epithelium, Metaplasia | | 1 2.0|
Respiratory Epithelium, Hyperplasia | 3 2 | 7 1.9|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 3 |
Cataract | 3 3 | 3 3.3|
Retina, Atrophy | 4 4 | 3 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Infarct | | 1 2.0|
Nephropathy | 2 2 2 3 1 1 2 2 3 2 2 2 1 1 2 2 2 2 1 2 2 1| 38 1.8|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 4| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 4| 3| 3| 1| 3| 1| 3| 3| 3| 3| 3| 0| 0| 3| 7| 7| 3| 3| 3| 3| 3|
| 4| 3| 3| 4| 9| 4| 3| 4| 3| 7| 4| 3| 4| 7| 4| 9| 0| 4| 6| 2| 4| 4| 5| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + I + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 |
Basophilic Focus | X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X X X X|
Degeneration, Cystic | 2 1 |
Eosinophilic Focus | X X X |
Fatty Change | 1 |
Hepatodiaphragmatic Nodule | X|
Inflammation, Granulomatous | 3 |
Mixed Cell Focus | |
Necrosis | 2 |
Bile Duct, Hyperplasia | 1 1 2 2 2 1 3 2 1 2 1 1 1 2 2 2 3 2 2 3 1 |
Centrilobular, Necrosis | 1 |
__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Necrosis | 3 2 2 3 3 |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 1 3 1 2 |
Basophilic Focus | X X X|
Hyperplasia | 3 4 |
Thrombosis | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Basophilic Focus | X |
Necrosis | 2 |
Duct, Metaplasia, Squamous | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | X |
Hyperplasia, Squamous | 4 |
Inflammation, Acute | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
Necrosis | 3 |
__________________________________________________________________________|
Tongue | + |
Hyperplasia, Squamous | 3 |
__________________________________________________________________________|
Tooth | + + |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 4| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 4| 3| 3| 1| 3| 1| 3| 3| 3| 3| 3| 0| 0| 3| 7| 7| 3| 3| 3| 3| 3|
| 4| 3| 3| 4| 9| 4| 3| 4| 3| 7| 4| 3| 4| 7| 4| 9| 0| 4| 6| 2| 4| 4| 5| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic Active | 3 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Necrosis, Fibrinoid | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 3 3 3 1 2 2 2 3 2 2 2 2 3 2 2 1 2 2 2 2|
Atrium, Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
Hyperplasia | 2 2 1 2 2 3 2 1 2 2 2 2 2 2|
Hypertrophy | 2 1 3 2 |
Necrosis | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 1 2 3 3 3 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + M M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 2 1 |
Pars Intermedia, Angiectasis | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 4 1 2 2 3 3 2 2 2 1 1 2 2 2 2 1 3 1 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Chronic Active | 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 3 4 2 1 2 3 |
Inflammation, Chronic Active | |
Inflammation, Suppurative | |
Necrosis | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 |
Artery, Inflammation, Chronic Active | 3 |
Interstitial Cell, Hyperplasia | 2 1 3 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 4| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 4| 3| 3| 1| 3| 1| 3| 3| 3| 3| 3| 0| 0| 3| 7| 7| 3| 3| 3| 3| 3|
| 4| 3| 3| 4| 9| 4| 3| 4| 3| 7| 4| 3| 4| 7| 4| 9| 0| 4| 6| 2| 4| 4| 5| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Reticulum Cell | 2 |
__________________________________________________________________________|
Lymph Node | |
Ectasia | |
__________________________________________________________________________|
Lymph Node, Bronchial | + M M M + + M + M M + + + + M + + M M + M + M M M|
__________________________________________________________________________|
Lymph Node, Mandibular | + M M + + M M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + M M M + + M M + + + + + + M + + M M + M + M M +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 2 2 3 |
Hematopoietic Cell Proliferation | |
Hemorrhage | |
Hyperplasia, Focal | |
Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M + M M M M + + + + + M + M + M M + M + + + +|
Galactocele | 2 1 3 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 3 |
Epidermis, Hyperplasia | 3 |
Prepuce, Inflammation, Chronic Active| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Hemorrhage | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Chronic Active | 1 |
Inflammation, Suppurative | |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 1 1 1 1 2 1|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 4| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 4| 3| 3| 1| 3| 1| 3| 3| 3| 3| 3| 0| 0| 3| 7| 7| 3| 3| 3| 3| 3|
| 4| 3| 3| 4| 9| 4| 3| 4| 3| 7| 4| 3| 4| 7| 4| 9| 0| 4| 6| 2| 4| 4| 5| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 2 1 3 |
Thrombosis | |
Olfactory Epithelium, Atrophy | |
Olfactory Epithelium, Metaplasia | 3 2 1 2 3 |
Respiratory Epithelium, Hyperplasia | 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
Cataract | |
Retina, Atrophy | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 3 2 2 3 4 2 2 3 1 3 3 2 1 2 3 2 2 1 1 1 1 2 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 7| 6| 6| 5| 7| 7| 4| 7| 7| 5| 7| 7| 7| 4| 1| 6| 7| 7| 6| 6| 7| |
DAY ON TEST | 6| 3| 0| 5| 3| 5| 3| 5| 3| 3| 9| 3| 3| 2| 3| 3| 0| 0| 3| 7| 3| 3| 4| 9| 3| |
| 9| 4| 0| 2| 4| 6| 9| 1| 3| 5| 5| 4| 3| 5| 3| 4| 3| 8| 5| 2| 3| 4| 7| 7| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + I + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + A + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + A + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 2 1.5|
Basophilic Focus | X X X X X X X X X X X X X X X X| 29 |
Clear Cell Focus | X X X X X X X| 18 |
Degeneration, Cystic | 1 | 3 1.3|
Eosinophilic Focus | | 3 |
Fatty Change | 1 2 2 2 | 5 1.6|
Hepatodiaphragmatic Nodule | X X | 3 |
Inflammation, Granulomatous | | 1 3.0|
Mixed Cell Focus | X | 1 |
Necrosis | | 1 2.0|
Bile Duct, Hyperplasia | 1 1 2 2 2 1 2 1 2 1 2 3 1 2 2 2 1 2| 39 1.7|
Centrilobular, Necrosis | 1 1 2 2 | 5 1.4|
__________________________________________________________________________|____________|
Mesentery | + | 6 |
Fat, Necrosis | 2 | 6 2.5|
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 2 2 2 3 1 2 2| 14 1.9|
Basophilic Focus | | 3 |
Hyperplasia | | 2 3.5|
Thrombosis | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 2 | 2 1.5|
Basophilic Focus | X | 2 |
Necrosis | | 1 2.0|
Duct, Metaplasia, Squamous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Diverticulum | X | 2 |
Hyperplasia, Squamous | | 1 4.0|
Inflammation, Acute | 2 | 1 2.0|
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 7| 6| 6| 5| 7| 7| 4| 7| 7| 5| 7| 7| 7| 4| 1| 6| 7| 7| 6| 6| 7| |
DAY ON TEST | 6| 3| 0| 5| 3| 5| 3| 5| 3| 3| 9| 3| 3| 2| 3| 3| 0| 0| 3| 7| 3| 3| 4| 9| 3| |
| 9| 4| 0| 2| 4| 6| 9| 1| 3| 5| 5| 4| 3| 5| 3| 4| 3| 8| 5| 2| 3| 4| 7| 7| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mineralization | | 1 1.0|
Necrosis | 1 | 2 2.0|
__________________________________________________________________________|____________|
Tongue | + | 2 |
Hyperplasia, Squamous | 3 | 2 3.0|
__________________________________________________________________________|____________|
Tooth | | 2 |
Inflammation, Chronic Active | | 2 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
Necrosis, Fibrinoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 3 3 1 3 2 1 1 3 2 1 2 2 1 2 3 2 1 2 2 2 2 3| 44 2.1|
Atrium, Thrombosis | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 2 | 1 2.0|
Hyperplasia | 2 2 2 2 1 2 2 2 2 1 1 2 2 1 2 2 1 1 | 32 1.8|
Hypertrophy | 4 2 2| 7 2.3|
Necrosis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 4 1 3 2 2 2 2 2 3 3 3 1 3| 26 2.2|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 3| 4 2.3|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + + + + + + + M + M + + + + + +| 44 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Hyperplasia | 3 3 | 5 2.2|
Pars Intermedia, Angiectasis | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
C-Cell, Hyperplasia | 1 1 1 1 2 4 1 1 3 1 1 1 1 2 3 1 1 1 2 2 3| 41 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
Inflammation, Chronic Active | 2 | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 7| 6| 6| 5| 7| 7| 4| 7| 7| 5| 7| 7| 7| 4| 1| 6| 7| 7| 6| 6| 7| |
DAY ON TEST | 6| 3| 0| 5| 3| 5| 3| 5| 3| 3| 9| 3| 3| 2| 3| 3| 0| 0| 3| 7| 3| 3| 4| 9| 3| |
| 9| 4| 0| 2| 4| 6| 9| 1| 3| 5| 5| 4| 3| 5| 3| 4| 3| 8| 5| 2| 3| 4| 7| 7| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 2 1 1 2 1 | 14 1.9|
Inflammation, Chronic Active | 4 | 1 4.0|
Inflammation, Suppurative | 4 | 1 4.0|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 2 4 4 4 4| 8 3.3|
Artery, Inflammation, Chronic Active | 3 | 2 3.0|
Interstitial Cell, Hyperplasia | 1 1 1 | 6 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Reticulum Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 2 |
Ectasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M M + M M + + M + + + + + + + M + M M M + + M M| 26 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + M + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M M + M + + + + M M M M + + M M + + M M M + M M| 25 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 1 3 2| 8 2.4|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Hemorrhage | 2 2 | 2 2.0|
Hyperplasia, Focal | 2 | 1 2.0|
Necrosis | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + M + + + + + + M + + M + + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M + + + M M M M M + M + M + + M M + + M M + +| 24 |
Galactocele | 2 1 1 | 7 1.7|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 3 | 4 3.0|
Epidermis, Hyperplasia | | 1 3.0|
Prepuce, Inflammation, Chronic Active| 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 7| 6| 6| 5| 7| 7| 4| 7| 7| 5| 7| 7| 7| 4| 1| 6| 7| 7| 6| 6| 7| |
DAY ON TEST | 6| 3| 0| 5| 3| 5| 3| 5| 3| 3| 9| 3| 3| 2| 3| 3| 0| 0| 3| 7| 3| 3| 4| 9| 3| |
| 9| 4| 0| 2| 4| 6| 9| 1| 3| 5| 5| 4| 3| 5| 3| 4| 3| 8| 5| 2| 3| 4| 7| 7| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | | 1 |
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X | 1 |
Inflammation, Chronic Active | 1 1 2 1 | 5 1.2|
Inflammation, Suppurative | 4 | 1 4.0|
Thrombosis | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 3 2 1 3 1| 11 1.5|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 4 1 | 8 1.4|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 2 2 2 1 | 9 2.0|
Thrombosis | 3 1 1 4 | 4 2.3|
Olfactory Epithelium, Atrophy | 2 | 1 2.0|
Olfactory Epithelium, Metaplasia | 2 | 6 2.2|
Respiratory Epithelium, Hyperplasia | 1 2 2 2 | 5 1.8|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + | 1 |
Cataract | 3 | 1 3.0|
Retina, Atrophy | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy | 2 2 2 2 3 1 1 1 4 3 1 1 1 2 2 3 1 2 2 2 1 3 3| 47 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Transitional Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 2| 3| 3| 2| 5| 3| 3| 1| 3| 3| 8| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 0| 3|
| 3| 3| 5| 3| 8| 8| 4| 5| 4| 4| 5| 4| 3| 3| 3| 4| 3| 4| 3| 3| 3| 3| 4| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.03 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X X X X X X X X X |
Degeneration, Cystic | 2 2 1 1 1 |
Eosinophilic Focus | X X X |
Fatty Change | 1 3 2 |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Chronic Active | |
Necrosis | |
Bile Duct, Hyperplasia | 2 1 2 2 2 2 2 2 2 1 2 2 1 1 3 1 1 1 3 2|
Centrilobular, Necrosis | 1|
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 1 1 4 1 1 2 2 |
Basophilic Focus | X |
Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 2 2 2 3 2 1 2 2 2 2 1 2 2 2 3 1 3 1 3 2|
Atrium, Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 |
Degeneration, Cystic | 2 |
Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Hypertrophy | 3 1 2 |
Necrosis | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 2| 3| 3| 2| 5| 3| 3| 1| 3| 3| 8| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 0| 3|
| 3| 3| 5| 3| 8| 8| 4| 5| 4| 4| 5| 4| 3| 3| 3| 4| 3| 4| 3| 3| 3| 3| 4| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.03 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 2 2 2 3 2 2 2 4 3 3 |
Thrombosis | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2|
__________________________________________________________________________|
Parathyroid Gland | + + + M + M + M + + + + + M + + + + + + + + + + +|
Hyperplasia | |
Hypertrophy | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia | 3 2 4 1 2 3 3 |
Pars Intermedia, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 2 1 4 2 2 2 2 2 2 1 2 3 2 1 2 1 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 1 1 1 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 |
Necrosis | 2 |
Artery, Inflammation, Chronic Active | |
Interstitial Cell, Hyperplasia | 2 1 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | |
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Bronchial | M M M + + + + M + M + M M + M + M M M + + + M + +|
Foreign Body | 2 3 2 3 3 3 3 3 1 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + M M + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M M + M M M + M + M M M M + M M M M M M M + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 2| 3| 3| 2| 5| 3| 3| 1| 3| 3| 8| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 0| 3|
| 3| 3| 5| 3| 8| 8| 4| 5| 4| 4| 5| 4| 3| 3| 3| 4| 3| 4| 3| 3| 3| 3| 4| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.03 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Foreign Body | 4 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 2 3 1 3 2 2 3|
Hematopoietic Cell Proliferation | 4 |
Hyperplasia, Focal | 3 |
Necrosis | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M + M + + + + M + M M + + + M + M M + + M M +|
Galactocele | 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 |
Inflammation, Acute | 2 2 |
Epiglottis, Metaplasia, Squamous | 2 |
Respiratory Epithelium, Hyperplasia | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Squamous | 4 |
Foreign Body | 3 2 3 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 3 2 2 2 3 2|
Hemorrhage | |
Hyperplasia, Atypical | 4 4 4 2 3 2 4 4 2 2 2 4 |
Inflammation, Chronic Active | 4 4 4 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 3 3|
Inflammation, Suppurative | |
Metaplasia, Squamous | 2 |
Alveolar Epithelium, Hyperplasia | 4 2 1 2 4 2 1 4 2 |
Alveolar Epithelium, Metaplasia | 4 4 4 4 3 3 4 2 4 4 4 4 4 4 2 4 3 3 4 4 4 4 |
Alveolus, Proteinosis | 4 4 4 4 4 4 4 4 4 4 4 2 4 3 4 3 4 4 4 4 3 4 4 4 3|
Interstitium, Fibrosis | 4 4 4 4 3 3 4 4 4 4 3 4 4 4 4 4 4 4 4 4 4 4 4 3|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 3 2 2 3|
Thrombosis | 2 |
Olfactory Epithelium, Atrophy | 2 1 |
Olfactory Epithelium, Metaplasia | 2 |
Respiratory Epithelium, Hyperplasia | 2 2 3 3|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 2| 3| 3| 2| 5| 3| 3| 1| 3| 3| 8| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 0| 3|
| 3| 3| 5| 3| 8| 8| 4| 5| 4| 4| 5| 4| 3| 3| 3| 4| 3| 4| 3| 3| 3| 3| 4| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.03 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Pleura | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 4|
Nephropathy | 4 3 2 2 3 2 2 2 2 2 3 4 2 2 2 2 2 2 1 2 4 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 6| 5| 7| 6| 6| 2| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 3| 8| 3| 0| 3| 4| 0| 8| 6| 0| 8| 9| 8| 3| 3| 7| 3| 8| 3| 3| 3| 3| 3| 3| 2| |
| 5| 3| 3| 2| 4| 3| 1| 6| 9| 7| 5| 5| 5| 3| 3| 6| 3| 6| 4| 4| 4| 4| 4| 5| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.03 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + A + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 4 | 2 2.5|
Basophilic Focus | X X X X X X X X X X X X | 29 |
Clear Cell Focus | X X X X | 16 |
Degeneration, Cystic | 1 2 2 2 | 9 1.6|
Eosinophilic Focus | | 3 |
Fatty Change | 2 2 | 5 2.0|
Hepatodiaphragmatic Nodule | X X | 4 |
Inflammation, Chronic Active | 1| 1 1.0|
Necrosis | 3 | 1 3.0|
Bile Duct, Hyperplasia | 1 2 2 2 2 2 2 2 2 2 2 3 2 3 2 2 2 2 2 2 2 1| 42 1.9|
Centrilobular, Necrosis | 3 1 1 | 4 1.5|
__________________________________________________________________________|____________|
Mesentery | + + + + | 6 |
Fat, Necrosis | 3 2 2 3 | 6 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 2 2 1 2 1 2 | 16 1.7|
Basophilic Focus | X X | 3 |
Hyperplasia | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 1 | 3 1.7|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 3 2 3 2 2 1 3 2 1 3 1 3 2 1 2 2 2 1 2 2 2 3 | 43 2.0|
Atrium, Thrombosis | 2 1 | 3 2.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 6| 5| 7| 6| 6| 2| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 3| 8| 3| 0| 3| 4| 0| 8| 6| 0| 8| 9| 8| 3| 3| 7| 3| 8| 3| 3| 3| 3| 3| 3| 2| |
| 5| 3| 3| 2| 4| 3| 1| 6| 9| 7| 5| 5| 5| 3| 3| 6| 3| 6| 4| 4| 4| 4| 4| 5| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.03 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Atrophy | | 2 2.5|
Degeneration, Cystic | | 1 2.0|
Hyperplasia | 2 3 2 2 2 2 2 2 2 4 2 2 2 | 27 2.1|
Hypertrophy | 2 2 | 5 2.0|
Necrosis | 3 2 | 2 2.5|
Vacuolization Cytoplasmic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 1 1 2 4 3 3 2 2 3 2 3 | 26 2.4|
Thrombosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 3 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M M + + + + + + + + + + + + + + + + + + + +| 44 |
Hyperplasia | 3 | 1 3.0|
Hypertrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 2 2 | 2 2.0|
Pars Distalis, Hyperplasia | 3 3 2 2 1 2 | 13 2.4|
Pars Intermedia, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 2 1 2 2 1 1 2 3 1 2 1 1 1 1| 31 1.8|
Follicular Cell, Hyperplasia | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
Inflammation, Chronic Active | 3 | 2 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 3 2 1 3 1| 13 1.6|
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 4 2.8|
Necrosis | | 1 2.0|
Artery, Inflammation, Chronic Active | 2 | 1 2.0|
Interstitial Cell, Hyperplasia | 1 1 2 | 7 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 6| 5| 7| 6| 6| 2| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 3| 8| 3| 0| 3| 4| 0| 8| 6| 0| 8| 9| 8| 3| 3| 7| 3| 8| 3| 3| 3| 3| 3| 3| 2| |
| 5| 3| 3| 2| 4| 3| 1| 6| 9| 7| 5| 5| 5| 3| 3| 6| 3| 6| 4| 4| 4| 4| 4| 5| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.03 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Thrombosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 4 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + M M + + + M + M + M M + + + + + + + M M + M M| 27 |
Foreign Body | 3 3 3 2 1 3 3 3 3 | 19 2.6|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + M + + + + + + + M + M + + + + + + M| 42 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M M M + M M + + + M + + + + + + + + M M + M M| 19 |
Foreign Body | 3 3 1 3 3 3 | 8 2.8|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 3 2 1 3 1 | 15 2.1|
Hematopoietic Cell Proliferation | 3 | 2 3.5|
Hyperplasia, Focal | | 1 3.0|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + M + + + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + M + M + + M + + + + + + + M + M + + + M| 33 |
Galactocele | 3 3 | 4 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | | 1 2.0|
Inflammation, Acute | 2 | 3 2.0|
Epiglottis, Metaplasia, Squamous | 2 | 2 2.0|
Respiratory Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst, Squamous | | 1 4.0|
Foreign Body | 2 2 2 2 2 1 2 3 2 3 2 2 2 2 2 2 2 2 2 3 2 3 2 2 2| 50 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 6| 5| 7| 6| 6| 2| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 3| 8| 3| 0| 3| 4| 0| 8| 6| 0| 8| 9| 8| 3| 3| 7| 3| 8| 3| 3| 3| 3| 3| 3| 2| |
| 5| 3| 3| 2| 4| 3| 1| 6| 9| 7| 5| 5| 5| 3| 3| 6| 3| 6| 4| 4| 4| 4| 4| 5| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.03 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Hemorrhage | 4 | 1 4.0|
Hyperplasia, Atypical | 4 4 2 3| 16 3.1|
Inflammation, Chronic Active | 4 3 4 4 4 3 4 4 4 4 3 4 3 4 4 4 4 4 4 3 4 4 4 4 4| 50 3.8|
Inflammation, Suppurative | 4 | 1 4.0|
Metaplasia, Squamous | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 3 2 1 2 2 3 2 3 4 2 2 | 20 2.4|
Alveolar Epithelium, Metaplasia | 2 1 4 3 4 2 4 2 2 3 2 1 4 2 2 2 2 2 3 3 4 4 3| 45 3.1|
Alveolus, Proteinosis | 4 4 4 3 4 3 4 4 4 4 3 4 3 4 3 4 3 3 4 4 4 4 4 4 4| 50 3.7|
Interstitium, Fibrosis | 3 3 4 4 4 3 4 4 3 3 2 4 3 4 4 4 4 3 4 4 4 4 4 4 4| 49 3.7|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 2 1 1| 10 2.0|
Thrombosis | 4 3 2 | 4 2.8|
Olfactory Epithelium, Atrophy | | 2 1.5|
Olfactory Epithelium, Metaplasia | 1 | 2 1.5|
Respiratory Epithelium, Hyperplasia | 2 3 2 | 7 2.4|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pleura | + + | 2 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 | 3 1.3|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | | 1 4.0|
Nephropathy | 4 2 4 3 2 1 2 1 2 2 1 3 4 2 1 2 1 3 3 2 4 2 4 2| 46 2.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
_____________________________________________________________________________________________________________________
| 7| 4| 6| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 6| 6|
DAY ON TEST | 3| 9| 6| 5| 3| 3| 3| 3| 3| 5| 3| 3| 3| 0| 3| 3| 1| 3| 7| 3| 6| 4| 3| 9| 5|
| 3| 3| 7| 2| 3| 4| 4| 3| 4| 8| 4| 4| 3| 0| 3| 5| 0| 4| 9| 3| 5| 4| 3| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.1MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + + + + + + + A + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + A + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + A + + + A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X X X |
Degeneration, Cystic | 2 3 2 2 |
Eosinophilic Focus | X X |
Fatty Change | 1 3 2 1|
Hepatodiaphragmatic Nodule | X |
Necrosis | |
Regeneration | 3 2 3 |
Vacuolization Cytoplasmic, Focal | |
Bile Duct, Hyperplasia | 2 2 2 3 2 1 3 3 2 1 1 3 1 2 2 1 3 2 2 1|
Centrilobular, Necrosis | 1 2 1 1 |
Serosa, Fibrosis | |
Serosa, Hemorrhage | 2 |
__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Metaplasia, Osseous | 2 |
Fat, Necrosis | 2 3 2 2 2 |
__________________________________________________________________________|
Oral Mucosa | + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 1 2 1 2 |
Basophilic Focus | X X X |
Hyperplasia | 3 3 2 |
Duct, Hyperplasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | |
Inflammation, Acute | 2 |
Necrosis | 2 |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + A + + + + + + + + + + + + + + + + + + A + + + +|
Mineralization | 1 3 |
Necrosis | 1 |
__________________________________________________________________________|
Tooth | + |
Developmental Malformation | X |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
_____________________________________________________________________________________________________________________
| 7| 4| 6| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 6| 6|
DAY ON TEST | 3| 9| 6| 5| 3| 3| 3| 3| 3| 5| 3| 3| 3| 0| 3| 3| 1| 3| 7| 3| 6| 4| 3| 9| 5|
| 3| 3| 7| 2| 3| 4| 4| 3| 4| 8| 4| 4| 3| 0| 3| 5| 0| 4| 9| 3| 5| 4| 3| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.1MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 1 1 2 3 2 2 1 3 2 3 2 1 2 2 2 2 2 3 3 1 3 3 1|
Artery, Mineralization | 2 |
Atrium, Thrombosis | 1 |
Epicardium, Fibrosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3|
Hyperplasia | 2 1 2 2 2 3 2 1 2 2 2 2 1 2 2 2|
Hypertrophy | 1 2 |
Necrosis | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 4 3 3 2 2 2 3 2 3 1 3|
Necrosis | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 3 3 2 2 |
__________________________________________________________________________|
Thyroid Gland | + A + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 2 1 2 3 1 2 1 1 1 1 4 1 3 1 1 1 2 2|
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 4 |
Hyperplasia | |
Inflammation, Chronic Active | 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 2 1 1 3 1 |
Inflammation, Chronic Active | 3 2 |
__________________________________________________________________________|
Seminal Vesicle | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Germinal Epithelium, Degeneration | |
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
_____________________________________________________________________________________________________________________
| 7| 4| 6| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 6| 6|
DAY ON TEST | 3| 9| 6| 5| 3| 3| 3| 3| 3| 5| 3| 3| 3| 0| 3| 3| 1| 3| 7| 3| 6| 4| 3| 9| 5|
| 3| 3| 7| 2| 3| 4| 4| 3| 4| 8| 4| 4| 3| 0| 3| 5| 0| 4| 9| 3| 5| 4| 3| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.1MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + + + M + + + + + + + + M + + M + + + + + M|
Foreign Body | 3 1 3 3 3 2 4 3 2 3 3 3 3 3 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M + + + + +|
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + I + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + M + + M + + + M + + + + + + M + + + + + + + +|
Foreign Body | 3 3 3 1 1 3 3 3 3 3 3 3 |
__________________________________________________________________________|
Spleen | + A + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Fibrosis | 2 3 2 |
Hemorrhage | |
Hyperplasia, Focal | |
Necrosis | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M + M + + M + M + + + + + + + M + + + M M + M|
Galactocele | 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X X |
Inflammation, Acute | 3 |
Necrosis | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Artery, Inflammation | 3 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 3 1 |
Epiglottis, Metaplasia, Squamous | 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Squamous | 3 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
_____________________________________________________________________________________________________________________
| 7| 4| 6| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 6| 6|
DAY ON TEST | 3| 9| 6| 5| 3| 3| 3| 3| 3| 5| 3| 3| 3| 0| 3| 3| 1| 3| 7| 3| 6| 4| 3| 9| 5|
| 3| 3| 7| 2| 3| 4| 4| 3| 4| 8| 4| 4| 3| 0| 3| 5| 0| 4| 9| 3| 5| 4| 3| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.1MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Foreign Body | 1 2 3 2 1 1 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 3 2|
Hyperplasia, Atypical | 4 2 4 4 2 4 4 4 4 1 4 |
Inflammation, Chronic Active | 4 4 3 3 3 3 3 3 3 4 3 4 3 4 4 4 4 4 3 3 4 3 3 3 4|
Metaplasia, Squamous | 3 |
Alveolar Epithelium, Hyperplasia | 2 2 4 2 2 2 3 1 2 3 1|
Alveolar Epithelium, Metaplasia | 4 3 2 2 2 4 4 2 3 2 4 3 4 4 4 4 4 2 3 3 4 1 1|
Alveolus, Proteinosis | 1 3 3 2 1 2 3 1 1 3 1 2 1 2 2 1 2 2 1 3 2 1 3 3|
Artery, Mediastinum, Mineralization | 2 |
Interstitium, Fibrosis | 4 3 3 3 3 4 4 3 3 4 4 4 3 4 4 4 4 4 3 4 3 3 4 3 4|
Mediastinum, Thrombosis | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 2 3 2 1 |
Thrombosis | 1 |
Lateral Wall, Metaplasia, Squamous | |
Olfactory Epithelium, Atrophy | |
Olfactory Epithelium, Metaplasia | 2 |
Respiratory Epithelium, Hyperplasia | 3 2 3 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + A + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
Retina, Atrophy | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 3 2 |
Infarct | 2 |
Mineralization | 2 |
Nephropathy | 2 2 2 2 3 2 3 3 2 2 1 1 2 3 3 2 2 2 1 2 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 3 |
Inflammation, Chronic Active | 3 |
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 7| 4| 7| 6| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 6| 6| 6| |
DAY ON TEST | 3| 1| 3| 3| 3| 6| 3| 3| 3| 3| 0| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 5| 4| 4| |
| 3| 3| 4| 7| 5| 0| 4| 0| 4| 4| 3| 4| 3| 4| 5| 2| 4| 4| 5| 4| 3| 5| 1| 4| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0.1MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + A + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + A + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X | 31 |
Clear Cell Focus | X X X X X X X X X X X X | 22 |
Degeneration, Cystic | 2 | 5 2.2|
Eosinophilic Focus | X X | 4 |
Fatty Change | 3 2 3 | 7 2.1|
Hepatodiaphragmatic Nodule | X | 2 |
Necrosis | 2 | 1 2.0|
Regeneration | | 3 2.7|
Vacuolization Cytoplasmic, Focal | 2 | 1 2.0|
Bile Duct, Hyperplasia | 2 2 1 2 1 2 2 2 1 2 1 2 2 2 1 3 2 3 2 1| 40 1.9|
Centrilobular, Necrosis | 2 2 | 6 1.5|
Serosa, Fibrosis | 2 | 1 2.0|
Serosa, Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 6 |
Fat, Metaplasia, Osseous | | 1 2.0|
Fat, Necrosis | 2 | 6 2.2|
__________________________________________________________________________|____________|
Oral Mucosa | + | 3 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 2 1 1 1 3 1 2 2 2 1 | 17 1.6|
Basophilic Focus | | 3 |
Hyperplasia | 3 | 4 2.8|
Duct, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | 3 2 1| 3 2.0|
Inflammation, Acute | 3 2 | 3 2.3|
Necrosis | | 1 2.0|
Ulcer | 3 3 3 | 4 3.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Mineralization | | 2 2.0|
Necrosis | 2 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 7| 4| 7| 6| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 6| 6| 6| |
DAY ON TEST | 3| 1| 3| 3| 3| 6| 3| 3| 3| 3| 0| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 5| 4| 4| |
| 3| 3| 4| 7| 5| 0| 4| 0| 4| 4| 3| 4| 3| 4| 5| 2| 4| 4| 5| 4| 3| 5| 1| 4| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0.1MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tooth | + + | 3 |
Developmental Malformation | | 1 |
Inflammation, Chronic Active | 3 4 | 2 3.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 3 2 2 2 3 1 3 2 2 3 3 1 2 2 2 2 2| 43 2.1|
Artery, Mineralization | | 1 2.0|
Atrium, Thrombosis | 4 | 2 2.5|
Epicardium, Fibrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | | 1 3.0|
Hyperplasia | 2 2 2 1 2 2 1 2 2 2 2 2 2 2 2 2 3| 33 1.9|
Hypertrophy | 2 | 3 1.7|
Necrosis | 3 2 | 2 2.5|
Vacuolization Cytoplasmic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + I + + + + + + + + + +| 49 |
Hyperplasia | 1 4 4 3 1 1 2 1 3 2 2 | 24 2.4|
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 3 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + M + + + M + + + + M + + + + + +| 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Hyperplasia | 4 2 3 4 2 2 4 2 | 12 2.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 |
C-Cell, Hyperplasia | 3 2 1 1 1 3 1 2 1 2 3 1 2 2 1 2 1 1 1 2 1| 42 1.6|
Follicular Cell, Hyperplasia | 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 2 4.0|
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 7| 4| 7| 6| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 6| 6| 6| |
DAY ON TEST | 3| 1| 3| 3| 3| 6| 3| 3| 3| 3| 0| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 5| 4| 4| |
| 3| 3| 4| 7| 5| 0| 4| 0| 4| 4| 3| 4| 3| 4| 5| 2| 4| 4| 5| 4| 3| 5| 1| 4| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0.1MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | | 2 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 4 1 3 | 13 2.0|
Inflammation, Chronic Active | 4 | 3 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 4 3 4 | 5 3.4|
Germinal Epithelium, Degeneration | 2 | 1 2.0|
Interstitial Cell, Hyperplasia | 1 2 1 1 2 2 | 6 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + M + M + + + + + + + + + + + + + + + + + + M| 41 |
Foreign Body | 2 1 3 2 3 2 3 3 3 3 3 3 | 27 2.7|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + M + + + + + + + + + + + + + + + + + + + + + +| 47 |
Infiltration Cellular, Plasma Cell | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + M + + + + + + + + + +| 45 |
Foreign Body | 3 3 3 3 2 3 2 3 3 3 3 3 3 3 4| 27 2.8|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 3 | 1 3.0|
Fibrosis | 2 3 3 2 1 3 | 9 2.3|
Hemorrhage | 3 2 | 2 2.5|
Hyperplasia, Focal | 3 | 1 3.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + I + + + + + + + + + + + + + + + + + I M + +| 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M M + + + M + M + + + M + M M + I + + + + + M| 31 |
Galactocele | 2 2 2 | 4 2.3|
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | | 2 |
Inflammation, Acute | | 1 3.0|
Necrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 7| 4| 7| 6| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 6| 6| 6| |
DAY ON TEST | 3| 1| 3| 3| 3| 6| 3| 3| 3| 3| 0| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 5| 4| 4| |
| 3| 3| 4| 7| 5| 0| 4| 0| 4| 4| 3| 4| 3| 4| 5| 2| 4| 4| 5| 4| 3| 5| 1| 4| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0.1MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 3.0|
Artery, Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Spinal Cord | +| 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | 1 1 | 5 1.4|
Epiglottis, Metaplasia, Squamous | | 1 1.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst, Squamous | 3 3 | 3 3.0|
Foreign Body | 2 2 2 2 2 2 2 2 2 1 1 1 2 2 2 2 2 2 2 2 2 2 1 2 1| 50 1.9|
Hyperplasia, Atypical | 4 4 2 2 4 4 2 4 4 4 4 2 | 23 3.3|
Inflammation, Chronic Active | 4 3 3 3 4 3 3 4 4 3 3 3 4 3 3 3 4 4 4 3 3 3 4 4 3| 50 3.4|
Metaplasia, Squamous | 4 2 | 3 3.0|
Alveolar Epithelium, Hyperplasia | 3 2 1 2 2 2 2 2 2 2 | 21 2.1|
Alveolar Epithelium, Metaplasia | 4 1 3 2 3 2 4 3 2 1 3 3 1 4 4 4 2 4 1 4 2 1| 45 2.8|
Alveolus, Proteinosis | 2 3 1 2 1 3 1 3 2 1 3 2 2 2 2 3 2 2 1 3 2 4 1 3| 48 2.0|
Artery, Mediastinum, Mineralization | | 1 2.0|
Interstitium, Fibrosis | 4 3 4 2 4 2 4 4 4 4 2 4 4 3 3 3 4 4 4 3 4 3 4 4 3| 50 3.5|
Mediastinum, Thrombosis | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 2 1 | 8 1.6|
Thrombosis | 1 2 4 3 4 | 6 2.5|
Lateral Wall, Metaplasia, Squamous | 2 | 1 2.0|
Olfactory Epithelium, Atrophy | 1 | 1 1.0|
Olfactory Epithelium, Metaplasia | 3 | 2 2.5|
Respiratory Epithelium, Hyperplasia | 2 | 4 2.5|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Cataract | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 7| 4| 7| 6| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 6| 6| 6| |
DAY ON TEST | 3| 1| 3| 3| 3| 6| 3| 3| 3| 3| 0| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 5| 4| 4| |
| 3| 3| 4| 7| 5| 0| 4| 0| 4| 4| 3| 4| 3| 4| 5| 2| 4| 4| 5| 4| 3| 5| 1| 4| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0.1MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Retina, Atrophy | 4 | 1 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydronephrosis | | 2 2.5|
Infarct | 2 | 2 2.0|
Mineralization | | 1 2.0|
Nephropathy | 3 3 1 2 1 3 1 2 3 3 3 4 2 2 2 2 2 3 2 3 1| 43 2.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + M + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 2 2.5|
Inflammation, Chronic Active | | 1 3.0|
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 5| 7| 7| 7| 7| 5|
DAY ON TEST | 7| 3| 3| 4| 3| 8| 3| 6| 3| 3| 3| 9| 3| 3| 3| 4| 3| 3| 7| 3| 3| 3| 3| 3| 6|
| 6| 4| 3| 7| 3| 4| 5| 0| 4| 3| 3| 5| 3| 3| 3| 5| 0| 3| 6| 2| 5| 5| 3| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.3MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + + A + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + A + A + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + A + + + + + + + + + + + + A + + + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 3 |
Basophilic Focus | X X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X X X X X X |
Degeneration, Cystic | 1 2 |
Eosinophilic Focus | |
Fatty Change | 2 1 |
Hepatodiaphragmatic Nodule | X X X X |
Inflammation, Granulomatous | 2 |
Mixed Cell Focus | X |
Necrosis | 2 |
Bile Duct, Hyperplasia | 2 1 1 2 2 2 2 2 2 3 2 2 2 2 2 2 |
Centrilobular, Necrosis | 2 2|
__________________________________________________________________________|
Mesentery | + + + + +|
Artery, Inflammation, Chronic Active | |
Artery, Mineralization | |
Fat, Necrosis | 2 3 2 2 |
__________________________________________________________________________|
Oral Mucosa | |
Gingival, Abscess | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 2 2 2 1 3 2 2 |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Basophilic Focus | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Basal Cell | 2 |
Hyperplasia, Squamous | 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 |
__________________________________________________________________________|
Tooth | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 5| 7| 7| 7| 7| 5|
DAY ON TEST | 7| 3| 3| 4| 3| 8| 3| 6| 3| 3| 3| 9| 3| 3| 3| 4| 3| 3| 7| 3| 3| 3| 3| 3| 6|
| 6| 4| 3| 7| 3| 4| 5| 0| 4| 3| 3| 5| 3| 3| 3| 5| 0| 3| 6| 2| 5| 5| 3| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.3MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 3 2 1 2 2 1 2 2 2 2 2 3 1 3 1 2 2 2 2 2 |
Necrosis | 2 |
Artery, Mineralization | |
Atrium, Thrombosis | |
Mesothelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Degeneration, Cystic | 3 |
Hyperplasia | 2 2 2 2 3 2 2 2 2 2 2 3 2 1 2 2 |
Hypertrophy | 1 3 2 |
Necrosis | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 1 3 3 2 4 2 2 3 2 2 2 4 |
Thrombosis | 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + M M M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Pars Distalis, Hyperplasia | 2 3 3 2 4 3 2 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + A + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 2 1 1 2 2 1 1 1 1 1 3 2 1 1 2|
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic Active | 2 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 1 1 2 |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 3 4 2 4 3 3 |
Artery, Inflammation, Chronic Active | 2 3 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 5| 7| 7| 7| 7| 5|
DAY ON TEST | 7| 3| 3| 4| 3| 8| 3| 6| 3| 3| 3| 9| 3| 3| 3| 4| 3| 3| 7| 3| 3| 3| 3| 3| 6|
| 6| 4| 3| 7| 3| 4| 5| 0| 4| 3| 3| 5| 3| 3| 3| 5| 0| 3| 6| 2| 5| 5| 3| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.3MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Interstitial Cell, Hyperplasia | 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Lymph Node | + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + M + + + + + + M + + + + + +|
Foreign Body | 2 1 4 3 3 3 3 3 3 2 3 2 3 3 4 4 |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + M M + + + + M M + + + + M + + + + + + + +|
Foreign Body | 3 3 2 3 4 3 4 1|
Hyperplasia | 2 |
__________________________________________________________________________|
Spleen | + + + A + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 2 2 3 1 3 2 |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | |
Hyperplasia, Focal | 2 |
Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + M + + + + + + + + +|
Cyst | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M M M M M M + + M M + + M M M M + M + + M + M|
Galactocele | 3 2 |
__________________________________________________________________________|
Skin | + + + + + I + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 4 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 2|
Inflammation, Acute | 1|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Squamous | 2 |
Foreign Body | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 3|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 5| 7| 7| 7| 7| 5|
DAY ON TEST | 7| 3| 3| 4| 3| 8| 3| 6| 3| 3| 3| 9| 3| 3| 3| 4| 3| 3| 7| 3| 3| 3| 3| 3| 6|
| 6| 4| 3| 7| 3| 4| 5| 0| 4| 3| 3| 5| 3| 3| 3| 5| 0| 3| 6| 2| 5| 5| 3| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.3MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hyperplasia, Atypical | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 |
Inflammation, Chronic Active | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4|
Metaplasia, Squamous | 1 3 2 |
Alveolar Epithelium, Hyperplasia | 3 3 2 2 2 2 3 3 2 3 3 2 3 2 3 3 |
Alveolar Epithelium, Metaplasia | 4 2 2 4 4 2 2 4 3 4 3 2 4 4 2 4 4 4 4 4 4 4 4 4|
Alveolus, Proteinosis | 4 3 3 4 3 3 4 4 3 4 2 2 3 3 4 4 1 4 3 3 4 4 4|
Interstitium, Fibrosis | 4 4 4 4 4 4 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 2 2 3 |
Thrombosis | 2 4|
Glands, Hyperplasia | |
Olfactory Epithelium, Metaplasia | 1 2 1 1 |
Respiratory Epithelium, Hyperplasia | 3 2 3 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
Respiratory Epithelium, Necrosis | |
__________________________________________________________________________|
Pleura | +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
Retina, Atrophy | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | |
Infarct | 4 |
Nephropathy | 3 2 3 2 2 2 2 2 2 2 2 2 2 2 1 2 3 3 2 2 4 2|
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 6| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 6| |
DAY ON TEST | 2| 3| 5| 2| 7| 7| 3| 5| 3| 3| 3| 7| 3| 8| 3| 0| 3| 3| 3| 0| 2| 3| 3| 2| 5| |
| 8| 4| 6| 5| 1| 2| 3| 8| 5| 4| 3| 2| 4| 6| 4| 6| 4| 0| 3| 3| 8| 4| 4| 1| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
0.3MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + A +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + A +| 46 |
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + A +| 48 |
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + A + + + A +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + A +| 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 2 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X| 34 |
Clear Cell Focus | X X X X X X X | 16 |
Degeneration, Cystic | 2 1 2 | 5 1.6|
Eosinophilic Focus | X X X | 3 |
Fatty Change | 3 | 3 2.0|
Hepatodiaphragmatic Nodule | X X X X X | 9 |
Inflammation, Granulomatous | | 1 2.0|
Mixed Cell Focus | X | 2 |
Necrosis | | 1 2.0|
Bile Duct, Hyperplasia | 3 2 3 2 2 1 2 2 2 3 3 3 3 2 1 3 3 1 4 3| 36 2.2|
Centrilobular, Necrosis | 1 1 1 1 3 1 3 1| 10 1.6|
__________________________________________________________________________|____________|
Mesentery | + + + | 8 |
Artery, Inflammation, Chronic Active | 3 | 1 3.0|
Artery, Mineralization | 3 | 1 3.0|
Fat, Necrosis | 1 3 | 6 2.2|
__________________________________________________________________________|____________|
Oral Mucosa | + + | 2 |
Gingival, Abscess | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 2 2 2 2 2 1 3 2 2| 19 1.9|
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 2 | 2 2.0|
Basophilic Focus | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Basal Cell | | 1 2.0|
Hyperplasia, Squamous | 4 | 2 3.0|
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + A +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 6| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 6| |
DAY ON TEST | 2| 3| 5| 2| 7| 7| 3| 5| 3| 3| 3| 7| 3| 8| 3| 0| 3| 3| 3| 0| 2| 3| 3| 2| 5| |
| 8| 4| 6| 5| 1| 2| 3| 8| 5| 4| 3| 2| 4| 6| 4| 6| 4| 0| 3| 3| 8| 4| 4| 1| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
0.3MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mineralization | 1 | 3 1.0|
__________________________________________________________________________|____________|
Tooth | +| 1 |
Inflammation, Chronic Active | 3| 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 3 2 1 2 2 1 2 2 2 3 1 1 1 2 1 2 1 2 2 3 2 2 2 2| 46 1.9|
Necrosis | | 1 2.0|
Artery, Mineralization | 1 | 1 1.0|
Atrium, Thrombosis | 4 | 1 4.0|
Mesothelium, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
Degeneration, Cystic | | 1 3.0|
Hyperplasia | 3 2 1 2 2 1 2 2 2 3 2 2 2 2 1 2 3| 33 2.0|
Hypertrophy | 2 2 2 2 2 3| 9 2.1|
Necrosis | 3 1 3 | 4 2.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 2 3 2 2 1 1 3 2 4 2 2 3 2 | 32 2.3|
Thrombosis | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 1.0|
Pars Distalis, Hyperplasia | 1 3 4 2 2 4 1 | 15 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + A +| 48 |
C-Cell, Hyperplasia | 1 2 1 1 2 1 1 2 2 1 1 2 2 1 1 2 2 2 1 | 37 1.5|
Follicular Cell, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Penis | + | 1 |
Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 6| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 6| |
DAY ON TEST | 2| 3| 5| 2| 7| 7| 3| 5| 3| 3| 3| 7| 3| 8| 3| 0| 3| 3| 3| 0| 2| 3| 3| 2| 5| |
| 8| 4| 6| 5| 1| 2| 3| 8| 5| 4| 3| 2| 4| 6| 4| 6| 4| 0| 3| 3| 8| 4| 4| 1| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
0.3MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 1 3.0|
Inflammation, Chronic Active | 2 | 4 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 1 | 9 1.4|
Inflammation, Chronic Active | 2 4 | 3 3.3|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + A +| 49 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 4 4 | 10 3.4|
Artery, Inflammation, Chronic Active | | 2 2.5|
Interstitial Cell, Hyperplasia | 2 1 2 2 1 1| 9 1.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 3| 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + M + + + + + + M + + + + + + + + + + + + M| 44 |
Foreign Body | 3 1 3 3 4 3 2 3 2 2 2 2 4 2 4 2 1 3 3 3 | 36 2.7|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M M + + + + + + M + + + + + + + + + + + + +| 47 |
Infiltration Cellular, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + M + + + + + + M + + + + + + + + M + + + M| 40 |
Foreign Body | 3 3 2 4 3 3 3 | 15 2.9|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + A +| 48 |
Fibrosis | 2 1 3 2 | 11 2.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hemorrhage | 1 | 1 1.0|
Hyperplasia, Focal | | 1 2.0|
Necrosis | 2| 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + M + + M + + + + + + + + + M + + + + + + +| 45 |
Cyst | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + M M + + M + + M M + M + M + M M + + + + +| 24 |
Galactocele | 2 2 2 | 5 2.2|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperkeratosis | 4 3 | 3 3.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 6| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 6| |
DAY ON TEST | 2| 3| 5| 2| 7| 7| 3| 5| 3| 3| 3| 7| 3| 8| 3| 0| 3| 3| 3| 0| 2| 3| 3| 2| 5| |
| 8| 4| 6| 5| 1| 2| 3| 8| 5| 4| 3| 2| 4| 6| 4| 6| 4| 0| 3| 3| 8| 4| 4| 1| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
0.3MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 4 3 3 1 | 4 2.8|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | | 2 2.0|
Inflammation, Acute | 3 2 | 3 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst, Squamous | 4 | 2 3.0|
Foreign Body | 2 2 2 3 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2| 50 2.1|
Hyperplasia, Atypical | 4 4 4 2 4 2 4 4 4 4 2 4 4 4 4 4 4 4 4 4 | 39 3.8|
Inflammation, Chronic Active | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4| 50 4.0|
Metaplasia, Squamous | 4 | 4 2.5|
Alveolar Epithelium, Hyperplasia | 2 3 2 4 2 3 2 4 2 2 2 3 2 2 4 | 31 2.6|
Alveolar Epithelium, Metaplasia | 2 2 2 1 4 1 4 4 4 4 4 1 4 4 4 3 4 4 4 2 2 4 1 4 | 48 3.2|
Alveolus, Proteinosis | 2 3 4 4 4 2 4 4 3 4 4 3 4 4 2 4 3 3 4 3 4 4 4 3| 47 3.4|
Interstitium, Fibrosis | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4| 50 3.9|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 2 1 | 8 1.8|
Thrombosis | 2 3 2 1 3 2| 8 2.4|
Glands, Hyperplasia | 2 | 1 2.0|
Olfactory Epithelium, Metaplasia | 1 1 2 | 7 1.3|
Respiratory Epithelium, Hyperplasia | 3 3 | 5 2.8|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 3 | 1 3.0|
Respiratory Epithelium, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pleura | + | 2 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + A +| 49 |
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Cataract | 3 | 1 3.0|
Retina, Atrophy | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:05:35
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 6| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 6| |
DAY ON TEST | 2| 3| 5| 2| 7| 7| 3| 5| 3| 3| 3| 7| 3| 8| 3| 0| 3| 3| 3| 0| 2| 3| 3| 2| 5| |
| 8| 4| 6| 5| 1| 2| 3| 8| 5| 4| 3| 2| 4| 6| 4| 6| 4| 0| 3| 3| 8| 4| 4| 1| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
0.3MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | 3 | 1 3.0|
Infarct | | 1 4.0|
Nephropathy | 2 3 2 3 2 1 2 1 2 3 3 2 3 2 2 3 2 3 2 2 2 2 3 2| 46 2.2|
Renal Tubule, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------
--multipart-boundary
Content-type: text/plain
Range: bytes 617339-617339/617339
--multipart-boundary--