TDMS Study 88124-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest INDIUM PHOSPHIDE DATE: 10/28/99
EXPERIMENT: 88124 TEST: 03 TIME: 14:09:03
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-25335 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C88124
PATHOLOGIST: GRUMBEIN, S. CAS: 22398-80-7
------------------------------------------------------------------------------------------------------------------------------------
FINAL#1 CORE STUDY RATS
REASONS FOR REMOVAL: 25022 Accidently Killed
25019 Moribund Sacrifice
25020 Natural Death
25021 Terminal Sacrifice
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest INDIUM PHOSPHIDE DATE: 10/28/99
EXPERIMENT: 88124 TEST: 03 TIME: 14:09:03
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-25335 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C88124
PATHOLOGIST: GRUMBEIN, S. CAS: 22398-80-7
INDIUM PHOSPHIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 23 CENSORED DEATHS 0 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 135 408 476 495 525 537 551 552 569 600 |
| 617 624 639 647 649 656 672 672 697 700 |
| 703 709 714 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.03 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 285 526 569 576 586 628 635 643 658 683 |
| 684 685 686 695 700 701 702 707 714 714 |
| 723 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.1MG/M3 STOP |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 403 435 460 493 513 537 552 602 630 644 |
| 644 649 651 656 658 665 667 679 698 700 |
| 710 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
INDIUM PHOSPHIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.3MG/M3 STOP |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 24 CENSORED DEATHS 0 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 525 530 532 545 547 560 560 603 621 656 |
| 658 658 671 672 672 676 676 684 686 695 |
| 706 728 728 730 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
INDIUM PHOSPHIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 733 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 98.0 98.0 98.0 96.0 94.0 88.0 80.0 68.0 54.0 |
| | |
| | |
|0.03 | 100.0 100.0 100.0 98.0 98.0 98.0 96.0 90.0 82.0 58.0 |
|MG/M3 | |
| | |
|0.1MG/M3 | 100.0 100.0 100.0 100.0 98.0 94.0 88.0 84.0 68.0 58.0 |
|STOP | |
| | |
|0.3MG/M3 | 100.0 100.0 100.0 100.0 100.0 100.0 92.0 84.0 76.0 52.0 |
|STOP | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| MG/M3 STOP STOP |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 54.0% 58.0% 58.0% 52.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.817 P=0.570N P=0.803N P=1.000N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 589.0 642.9 602.2 638.3 |
|NATURAL DEATHS (C) | (26.9) (21.6) (20.3) (14.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 666.8 695.1 678.1 687.5 |
|(STANDARD ERROR) | (16.0) (11.0) (12.5) ( 9.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
INDIUM PHOSPHIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 735 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 124 397 476 504 550 551 566 590 615 621 |
| 667 667 669 684 697 726 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.03 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 1 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 120 428 481 484 551 560 580 597 607 683 |
| 686 694 695 695 714 714 725 728 |
| CENSORED DEATHS |
| 26 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.1MG/M3 STOP |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 0 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 225 436 448 566 595 600 656 672 679 684 |
| 686 686 714 716 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
INDIUM PHOSPHIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 735 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.3MG/M3 STOP |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 186 411 519 535 585 588 588 593 610 613 |
| 643 651 656 656 726 727 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
INDIUM PHOSPHIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 735 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 735 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 98.0 98.0 98.0 96.0 94.0 92.0 84.0 80.0 68.0 |
| | |
| | |
|0.03 | 100.0 98.0 98.0 98.0 98.0 91.8 91.8 83.7 81.6 63.3 |
|MG/M3 | |
| | |
|0.1MG/M3 | 100.0 100.0 98.0 98.0 98.0 94.0 94.0 88.0 86.0 72.0 |
|STOP | |
| | |
|0.3MG/M3 | 100.0 100.0 98.0 98.0 96.0 96.0 92.0 84.0 72.0 68.0 |
|STOP | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| MG/M3 STOP STOP |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 68.0% 63.3% 72.0% 68.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.959N P=0.850 P=0.726N P=1.000 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 569.0 596.8 597.4 580.4 |
|NATURAL DEATHS (C) | (37.1) (35.7) (37.4) (32.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 681.9 671.1 696.5 685.5 |
|(STANDARD ERROR) | (16.0) (20.5) (13.5) (14.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
INDIUM PHOSPHIDE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
0.03 MG/M3 = 2
0.1MG/M3 STOP = 3
0.3MG/M3 STOP = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 1 2 3 4
|
| 1 2 31 3 42
| 1 3 3 1 2 2
95 +
| 3 1 1 4 4 22
| 1 3 1 44 22
|
90 + 3 1 1 44 2 2
|
| 1 1 22
| 34 34 22
P 85 +
E | 1 1 34 43 2 2
R | 1 1 43 3 2 2
C |
E 80 + 1 1
N |
T | 11 33
| 1 1 4 4
S 75 +
U | 113 2 2
R |
V |
I 70 + 11 344 22
V |
A | 1 31
L | 334
65 +
| 13 122
| 4 4
|
60 + 112 2
|
| 11 2 2
|
55 +
| 1 4 1
| 4
|
50 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 24 obs hidden.
INDIUM PHOSPHIDE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
0.03 MG/M3 = 2
0.1MG/M3 STOP = 3
0.3MG/M3 STOP = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 4 3
|
| 1 4 3 1 4 23
| 1 4 233 12 4
95 +
| 3 122 1 4 4 3
| 1 4 1 3 4 3
| 2 2
P 90 + 22 33
E |
R | 121 2 3 3
C | 1 24 12 3 3
E 85 +
N | 1221 33
T | 11 33
| 2 2
S 80 + 41 4 1
U |
R | 44 2 2
V | 44 3 3
I 75 +
V | 1 1 33
A | 4 1 1 34 3
L | 2 2
70 + 1 1
|
| 2 1 1
|
65 +
| 2 2
|
|
60 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 11 obs hidden.
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