TDMS Study 88124-04 Pathology Tables
NTP Experiment-Test: 88124-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:17:14 FINAL#2, 2 YEAR CHRONIC Facility: Battelle Northwest Chemical CAS #: 22398-80-7 Lock Date: 10/02/98 Cage Range: All Reasons For Removal: 25022 Accidently Killed 25019 Moribund Sacrifice 25020 Natural Death 25021 Terminal Sacrifice Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 88124-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:17:14 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 0.03 0.1MG/M3 0.3MG/M3 MG/M3 STOP STOP ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 60 60 60 60 Early Deaths Accidently Killed 1 1 Moribund Sacrifice 4 31 15 18 Natural Death 3 6 2 10 Survivors Terminal Sacrifice 42 13 33 21 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Gallbladder (46) (45) (48) (43) Degeneration, Hyaline 1 (2%) Inflammation, Suppurative 2 (4%) 2 (4%) 3 (6%) Intestine Large, Rectum (47) (49) (50) (49) Inflammation, Suppurative 1 (2%) Intestine Small, Jejunum (46) (49) (49) (44) Peyer's Patch, Hyperplasia 1 (2%) Intestine Small, Ileum (46) (48) (50) (48) Epithelium, Hyperplasia 1 (2%) 1 (2%) 1 (2%) Peyer's Patch, Hyperplasia 2 (4%) 1 (2%) Liver (50) (50) (50) (50) Angiectasis 1 (2%) 2 (4%) Basophilic Focus 2 (4%) 2 (4%) 2 (4%) Clear Cell Focus 2 (4%) 2 (4%) Eosinophilic Focus 6 (12%) 5 (10%) 4 (8%) 10 (20%) Eosinophilic Focus, Multiple 4 (8%) 2 (4%) Hematopoietic Cell Proliferation 3 (6%) 3 (6%) 4 (8%) 3 (6%) Hyperplasia, Lymphoid 1 (2%) Inflammation 1 (2%) 1 (2%) Karyomegaly 1 (2%) Necrosis 4 (8%) 3 (6%) 9 (18%) 3 (6%) Tension Lipidosis 2 (4%) 1 (2%) 2 (4%) 1 (2%) Vacuolization Cytoplasmic 1 (2%) 1 (2%) Bile Duct, Cyst 1 (2%) Bile Duct, Degeneration, Hyaline 1 (2%) Mesentery (13) (8) (8) (4) Angiectasis 1 (8%) Artery, Inflammation 4 (50%) 2 (25%) 1 (25%) Fat, Necrosis 10 (77%) 3 (38%) 6 (75%) 3 (75%) Pancreas (50) (49) (50) (50) Atrophy 1 (2%) 1 (2%) 2 (4%) Salivary Glands (49) (50) (50) (50) Inflammation 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88124-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:17:14 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 0.03 0.1MG/M3 0.3MG/M3 MG/M3 STOP STOP ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Stomach, Forestomach (50) (49) (50) (50) Erosion 2 (4%) Foreign Body 1 (2%) Inflammation, Chronic 1 (2%) Ulcer 2 (4%) Epithelium, Hyperplasia 1 (2%) 4 (8%) 4 (8%) 3 (6%) Stomach, Glandular (49) (49) (50) (49) Inflammation, Suppurative 2 (4%) 1 (2%) 1 (2%) Necrosis, Focal 1 (2%) Epithelium, Hyperplasia 1 (2%) Tooth (1) (2) Inflammation 2 (100%) Malformation 1 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (50) (50) (50) Cardiomyopathy 45 (90%) 39 (78%) 46 (92%) 38 (76%) Mineralization 2 (4%) Necrosis 1 (2%) Artery, Inflammation 1 (2%) 16 (32%) 11 (22%) 13 (26%) Atrium, Thrombosis 1 (2%) 1 (2%) 1 (2%) 1 (2%) Epicardium, Inflammation 1 (2%) 5 (10%) 7 (14%) Pericardium, Inflammation 9 (18%) 4 (8%) Valve, Inflammation 1 (2%) Valve, Thrombosis 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (50) (50) (50) Amyloid Deposition 2 (4%) 1 (2%) 2 (4%) Degeneration, Cystic 1 (2%) 1 (2%) Degeneration, Focal 1 (2%) Hematopoietic Cell Proliferation 1 (2%) 1 (2%) Hyperplasia 1 (2%) Hypertrophy 9 (18%) 7 (14%) 3 (6%) 10 (20%) Capsule, Hyperplasia 1 (2%) Adrenal Medulla (49) (49) (50) (49) Hyperplasia 4 (8%) 5 (10%) 2 (4%) 3 (6%) Islets, Pancreatic (50) (49) (50) (50) Hyperplasia 2 (4%) 2 (4%) 1 (2%) Parathyroid Gland (34) (31) (29) (30) Hyperplasia 1 (3%) Pituitary Gland (50) (50) (48) (49) Pars Distalis, Hyperplasia 16 (32%) 15 (30%) 21 (44%) 15 (31%) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88124-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:17:14 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 0.03 0.1MG/M3 0.3MG/M3 MG/M3 STOP STOP ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Pars Intermedia, Hyperplasia 1 (2%) Thyroid Gland (50) (49) (50) (49) Inflammation, Suppurative 2 (4%) 4 (8%) 1 (2%) Follicle, Cyst 1 (2%) Follicular Cell, Hyperplasia 1 (2%) 2 (4%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (47) (46) (44) (47) Angiectasis 2 (4%) 2 (4%) 1 (2%) Cyst 12 (26%) 9 (20%) 11 (25%) 9 (19%) Thrombosis 1 (2%) 1 (2%) 2 (4%) Interstitial Cell, Hyperplasia 1 (2%) 1 (2%) 1 (2%) 1 (2%) Uterus (50) (49) (50) (50) Angiectasis 1 (2%) 3 (6%) 3 (6%) 5 (10%) Hydrometra 8 (16%) 8 (16%) 8 (16%) 5 (10%) Hyperplasia, Cystic 38 (76%) 31 (63%) 36 (72%) 32 (64%) Inflammation, Suppurative 1 (2%) 1 (2%) 1 (2%) Mineralization 1 (2%) Thrombosis 1 (2%) 2 (4%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (50) (50) (50) Fibrosis 2 (4%) 1 (2%) Hyperplasia 6 (12%) 13 (26%) 5 (10%) 7 (14%) Lymph Node (1) (5) (6) (8) Iliac, Angiectasis 1 (20%) Iliac, Hematopoietic Cell Proliferation 1 (13%) Iliac, Hyperplasia 1 (20%) 1 (13%) Lumbar, Angiectasis 1 (17%) Lumbar, Hemorrhage 1 (17%) Lumbar, Hyperplasia 1 (20%) 1 (13%) Lumbar, Inflammation, Chronic 1 (17%) Renal, Angiectasis 1 (17%) Lymph Node, Bronchial (36) (50) (48) (50) Foreign Body 44 (88%) 33 (69%) 40 (80%) Hematopoietic Cell Proliferation 1 (2%) Hyperplasia 5 (14%) 42 (84%) 31 (65%) 28 (56%) Artery, Inflammation 2 (4%) 1 (2%) 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88124-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:17:14 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 0.03 0.1MG/M3 0.3MG/M3 MG/M3 STOP STOP ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Lymph Node, Mandibular (36) (36) (43) (42) Hematopoietic Cell Proliferation 1 (2%) Hyperplasia 1 (2%) Lymph Node, Mesenteric (48) (49) (50) (48) Hematopoietic Cell Proliferation 1 (2%) 1 (2%) Hyperplasia 8 (17%) 6 (12%) 7 (14%) 7 (15%) Inflammation, Chronic Active 1 (2%) Lymph Node, Mediastinal (42) (48) (46) (49) Foreign Body 20 (42%) 7 (15%) 16 (33%) Hematopoietic Cell Proliferation 1 (2%) Hyperplasia 2 (5%) 40 (83%) 11 (24%) 29 (59%) Spleen (50) (49) (50) (49) Hematopoietic Cell Proliferation 16 (32%) 36 (73%) 26 (52%) 21 (43%) Hyperplasia, Lymphoid 15 (30%) 3 (6%) 11 (22%) 14 (29%) Metaplasia, Osseous 1 (2%) Thymus (47) (46) (42) (42) Hyperplasia, Lymphoid 3 (7%) 3 (7%) 2 (5%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (50) (50) (50) (50) Hyperplasia 2 (4%) 2 (4%) 4 (8%) 3 (6%) Metaplasia, Squamous 1 (2%) Skin (50) (50) (50) (50) Hyperplasia 1 (2%) Inflammation, Suppurative 2 (4%) 1 (2%) Hair Follicle, Atrophy 1 (2%) Subcutaneous Tissue, Angiectasis 1 (2%) Subcutaneous Tissue, Hemorrhage 1 (2%) Subcutaneous Tissue, Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%) Subcutaneous Tissue, Inflammation, Chronic Active 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (50) (50) Cyst 1 (2%) Fibrous Osteodystrophy 11 (22%) 14 (28%) 14 (28%) 16 (32%) Inflammation, Chronic 1 (2%) Maxilla, Fracture 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88124-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:17:14 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 0.03 0.1MG/M3 0.3MG/M3 MG/M3 STOP STOP ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (50) (50) Meninges, Infiltration Cellular, Mononuclear Cell 2 (4%) 2 (4%) 2 (4%) 2 (4%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Larynx (50) (50) (50) (50) Inflammation, Suppurative 1 (2%) 1 (2%) 2 (4%) Squamous Epithelium, Hyperplasia 9 (18%) 17 (34%) 10 (20%) 15 (30%) Lung (50) (50) (50) (50) Foreign Body 49 (98%) 35 (70%) 49 (98%) Hematopoietic Cell Proliferation 1 (2%) Hemorrhage 4 (8%) 3 (6%) 4 (8%) 4 (8%) Inflammation, Chronic Active 2 (4%) 49 (98%) 45 (90%) 50 (100%) Thrombosis 1 (2%) 1 (2%) Alveolar Epithelium, Hyperplasia 1 (2%) 1 (2%) 2 (4%) Alveolus, Infiltration Cellular, Histiocyte 2 (4%) 2 (4%) 3 (6%) Alveolus, Proteinosis 31 (62%) 8 (16%) Artery, Inflammation 1 (2%) 1 (2%) Artery, Mediastinum, Inflammation 1 (2%) Bronchiole, Bronchus, Degeneration, Hyaline 2 (4%) Interstitium, Fibrosis 1 (2%) 2 (4%) Mediastinum, Inflammation, Chronic Active 1 (2%) Perivascular, Infiltration Cellular, Mononuclear Cell 1 (2%) Serosa, Fibrosis 50 (100%) 47 (94%) 49 (98%) Serosa, Metaplasia, Osseous 1 (2%) Nose (50) (50) (50) (50) Angiectasis 1 (2%) Inflammation, Suppurative 7 (14%) 7 (14%) 7 (14%) 2 (4%) Olfactory Epithelium, Atrophy 6 (12%) 1 (2%) 3 (6%) 2 (4%) Olfactory Epithelium, Degeneration, Hyaline 3 (6%) 3 (6%) 10 (20%) 2 (4%) Respiratory Epithelium, Degeneration, Hyaline 28 (56%) 17 (34%) 27 (54%) 14 (28%) Respiratory Epithelium, Hyperplasia 1 (2%) Pleura (16) (3) (13) Mesothelium, Hyperplasia 16 (100%) 3 (100%) 13 (100%) Trachea (50) (48) (50) (50) Degeneration, Hyaline 1 (2%) Inflammation, Suppurative 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88124-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:17:14 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 0.03 0.1MG/M3 0.3MG/M3 MG/M3 STOP STOP ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (1) Degeneration 1 (100%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (49) (50) (50) Cyst 1 (2%) Inflammation, Chronic Active 1 (2%) Metaplasia, Osseous 2 (4%) 3 (6%) 4 (8%) 2 (4%) Nephropathy 37 (74%) 30 (61%) 43 (86%) 36 (72%) Artery, Inflammation 1 (2%) 3 (6%) Glomerulus, Inflammation, Chronic 1 (2%) Renal Tubule, Karyomegaly 1 (2%) Urinary Bladder (48) (49) (49) (48) Angiectasis 2 (4%) 1 (2%) 3 (6%) 2 (4%) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88124-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:17:14 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 0.03 0.1MG/M3 0.3MG/M3 MG/M3 STOP STOP ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 60 60 60 60 Early Deaths Natural Death 8 11 9 11 Moribund Sacrifice 5 14 12 12 Accidently Killed 1 Survivors Terminal Sacrifice 37 24 29 27 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Gallbladder (43) (43) (41) (38) Degeneration, Hyaline 1 (2%) 2 (5%) Inflammation, Chronic 1 (3%) Inflammation, Suppurative 1 (2%) 1 (2%) Epithelium, Hyperplasia 1 (2%) Intestine Large, Colon (49) (48) (48) (46) Inflammation, Chronic 1 (2%) 1 (2%) Intestine Large, Cecum (47) (47) (46) (46) Inflammation, Suppurative 1 (2%) Intestine Small, Jejunum (47) (44) (46) (44) Fibrosis 1 (2%) Inflammation, Acute 1 (2%) Inflammation, Chronic 1 (2%) Intestine Small, Ileum (45) (47) (43) (45) Amyloid Deposition 1 (2%) Artery, Inflammation 1 (2%) Epithelium, Hyperplasia 1 (2%) Peyer's Patch, Hyperplasia 5 (11%) 1 (2%) Liver (50) (50) (50) (50) Amyloid Deposition 2 (4%) Angiectasis 1 (2%) Basophilic Focus 2 (4%) 1 (2%) 2 (4%) Clear Cell Focus 1 (2%) 1 (2%) Clear Cell Focus, Multiple 1 (2%) 2 (4%) Eosinophilic Focus 9 (18%) 15 (30%) 14 (28%) 10 (20%) Eosinophilic Focus, Multiple 1 (2%) 1 (2%) 5 (10%) 8 (16%) Hematopoietic Cell Proliferation 1 (2%) Inflammation, Chronic Active 1 (2%) Inflammation, Focal, Granulomatous 1 (2%) 1 (2%) Mixed Cell Focus 1 (2%) 1 (2%) Necrosis 4 (8%) 4 (8%) 2 (4%) 7 (14%) Tension Lipidosis 2 (4%) 1 (2%) Vacuolization Cytoplasmic 2 (4%) 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88124-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:17:14 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 0.03 0.1MG/M3 0.3MG/M3 MG/M3 STOP STOP ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Mesentery (4) (5) (5) (8) Artery, Inflammation 4 (80%) 1 (20%) 1 (13%) Fat, Inflammation 1 (13%) Fat, Necrosis 4 (100%) 1 (20%) 4 (80%) 4 (50%) Pancreas (50) (50) (49) (47) Atrophy 3 (6%) 2 (4%) 2 (4%) Hypertrophy 2 (4%) Artery, Inflammation 1 (2%) Duct, Cyst 1 (2%) 1 (2%) Stomach, Forestomach (49) (50) (48) (50) Erosion 2 (4%) Infiltration Cellular 1 (2%) Infiltration Cellular, Mast Cell 1 (2%) Inflammation, Chronic 1 (2%) Inflammation, Suppurative 1 (2%) Ulcer 1 (2%) 2 (4%) 3 (6%) 1 (2%) Artery, Inflammation 1 (2%) Epithelium, Hyperplasia 2 (4%) 6 (12%) 8 (17%) 5 (10%) Stomach, Glandular (49) (49) (48) (47) Infiltration Cellular 1 (2%) Inflammation, Suppurative 1 (2%) 2 (4%) 2 (4%) Necrosis, Focal 1 (2%) 1 (2%) 1 (2%) Epithelium, Hyperplasia 1 (2%) 1 (2%) Tooth (2) (1) (2) Inflammation 2 (100%) 1 (100%) Malformation 2 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Blood Vessel (1) (2) (1) Inflammation 1 (100%) Mineralization 1 (100%) Aorta, Aneurysm 1 (50%) Aorta, Hemorrhage 1 (50%) Aorta, Inflammation 1 (50%) Aorta, Mineralization 1 (50%) Aorta, Necrosis 1 (50%) Heart (50) (50) (50) (50) Cardiomyopathy 39 (78%) 41 (82%) 42 (84%) 41 (82%) Hemorrhage 1 (2%) Mineralization 2 (4%) 1 (2%) Artery, Inflammation 3 (6%) 18 (36%) 14 (28%) 10 (20%) Artery, Mineralization 1 (2%) Atrium, Inflammation, Chronic 1 (2%) 1 (2%) Atrium, Metaplasia, Osseous 1 (2%) Atrium, Thrombosis 1 (2%) 2 (4%) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88124-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:17:14 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 0.03 0.1MG/M3 0.3MG/M3 MG/M3 STOP STOP ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - CONT Epicardium, Inflammation 2 (4%) 1 (2%) Pericardium, Inflammation 6 (12%) 5 (10%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (50) (48) (50) Amyloid Deposition 2 (4%) Angiectasis 1 (2%) Degeneration, Focal 1 (2%) Hematopoietic Cell Proliferation 1 (2%) Hyperplasia 1 (2%) 1 (2%) 2 (4%) 1 (2%) Hypertrophy 30 (60%) 15 (30%) 23 (48%) 19 (38%) Necrosis 1 (2%) Adrenal Medulla (50) (50) (48) (49) Hyperplasia 3 (6%) 2 (4%) 1 (2%) 6 (12%) Islets, Pancreatic (50) (50) (49) (47) Hyperplasia 8 (16%) 1 (2%) 3 (6%) 4 (9%) Parathyroid Gland (33) (30) (34) (34) Amyloid Deposition 1 (3%) Pituitary Gland (48) (47) (45) (50) Pars Distalis, Hyperplasia 1 (2%) 1 (2%) Pars Intermedia, Hyperplasia 1 (2%) 1 (2%) Thyroid Gland (47) (48) (47) (50) Amyloid Deposition 2 (4%) Follicle, Degeneration, Cystic 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (50) (50) (50) (50) Granuloma Sperm 2 (4%) 2 (4%) Inflammation 1 (2%) 1 (2%) 2 (4%) Preputial Gland (50) (50) (50) (49) Ectasia 25 (50%) 21 (42%) 19 (38%) 20 (41%) Hyperplasia, Squamous 1 (2%) Inflammation 5 (10%) 3 (6%) Prostate (50) (49) (48) (48) Inflammation, Suppurative 1 (2%) Seminal Vesicle (49) (47) (48) (47) Congestion 1 (2%) Testes (50) (50) (50) (50) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88124-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:17:14 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 0.03 0.1MG/M3 0.3MG/M3 MG/M3 STOP STOP ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM - CONT Angiectasis 1 (2%) Atrophy 6 (12%) 1 (2%) 2 (4%) 2 (4%) Inflammation, Granulomatous 1 (2%) Interstitial Cell, Hyperplasia 1 (2%) 2 (4%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (49) (50) (50) (50) Hyperplasia 5 (10%) 9 (18%) 6 (12%) 4 (8%) Lymph Node, Bronchial (35) (48) (45) (48) Foreign Body 43 (90%) 40 (89%) 40 (83%) Hyperplasia 2 (6%) 36 (75%) 22 (49%) 22 (46%) Artery, Inflammation 1 (2%) Lymph Node, Mandibular (28) (32) (33) (36) Hyperplasia 1 (4%) 2 (6%) 1 (3%) Lymph Node, Mesenteric (48) (47) (49) (45) Angiectasis 1 (2%) Hemorrhage 1 (2%) Hyperplasia 11 (23%) 2 (4%) 10 (20%) 10 (22%) Inflammation, Granulomatous 2 (4%) Artery, Inflammation 1 (2%) Lymph Node, Mediastinal (40) (49) (45) (48) Foreign Body 24 (49%) 14 (31%) 25 (52%) Hematopoietic Cell Proliferation 1 (2%) 1 (2%) Hyperplasia 34 (69%) 17 (38%) 27 (56%) Infiltration Cellular, Histiocyte 1 (2%) Artery, Inflammation 1 (2%) 2 (4%) 1 (2%) Spleen (50) (50) (48) (48) Amyloid Deposition 2 (4%) Angiectasis 2 (4%) 2 (4%) Hematopoietic Cell Proliferation 14 (28%) 34 (68%) 23 (48%) 29 (60%) Hyperplasia, Lymphoid 3 (6%) 4 (8%) 3 (6%) Thymus (35) (39) (41) (35) Epithelial Cell, Hyperplasia 1 (2%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (50) (50) (50) (50) Hyperplasia 2 (4%) 1 (2%) 2 (4%) Inflammation, Suppurative 1 (2%) 3 (6%) Mineralization 1 (2%) Ulcer 1 (2%) Prepuce, Inflammation, Chronic Active 1 (2%) 2 (4%) 3 (6%) 3 (6%) Subcutaneous Tissue, Edema 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88124-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:17:14 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 0.03 0.1MG/M3 0.3MG/M3 MG/M3 STOP STOP ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (49) (49) (50) (50) Fibrous Osteodystrophy 2 (4%) 2 (4%) 2 (4%) Hyperplasia 1 (2%) Maxilla, Fracture 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (50) (50) Degeneration 1 (2%) Developmental Malformation 1 (2%) Meninges, Infiltration Cellular, Mononuclear Cell 2 (4%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Larynx (50) (49) (49) (50) Inflammation, Suppurative 5 (10%) 3 (6%) 1 (2%) 4 (8%) Epiglottis, Metaplasia, Squamous 1 (2%) Squamous Epithelium, Hyperplasia 6 (12%) 3 (6%) 4 (8%) 7 (14%) Lung (50) (50) (50) (50) Foreign Body 49 (98%) 42 (84%) 49 (98%) Hemorrhage 5 (10%) 1 (2%) 2 (4%) 2 (4%) Infiltration Cellular, Mast Cell 1 (2%) Inflammation, Chronic Active 2 (4%) 50 (100%) 45 (90%) 46 (92%) Inflammation, Suppurative 1 (2%) Thrombosis 1 (2%) Alveolar Epithelium, Hyperplasia 2 (4%) 5 (10%) 3 (6%) 7 (14%) Alveolus, Infiltration Cellular, Histiocyte 1 (2%) Alveolus, Proteinosis 14 (28%) 10 (20%) Artery, Mediastinum, Inflammation 2 (4%) 2 (4%) Bronchiole, Hyperplasia 1 (2%) Interstitium, Fibrosis 2 (4%) Serosa, Cyst 1 (2%) Serosa, Fibrosis 50 (100%) 49 (98%) 50 (100%) Serosa, Metaplasia, Osseous 1 (2%) Nose (49) (50) (49) (50) Foreign Body 1 (2%) Hemorrhage 1 (2%) Inflammation, Suppurative 3 (6%) 5 (10%) 4 (8%) 5 (10%) Olfactory Epithelium, Atrophy 2 (4%) 4 (8%) 2 (4%) 1 (2%) Olfactory Epithelium, Degeneration, Hyaline 1 (2%) Respiratory Epithelium, Degeneration, Hyaline 5 (10%) 2 (4%) 3 (6%) 4 (8%) Pleura (19) (4) (6) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88124-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:17:14 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 0.03 0.1MG/M3 0.3MG/M3 MG/M3 STOP STOP ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - CONT Mesothelium, Hyperplasia 19 (100%) 4 (100%) 6 (100%) Trachea (48) (46) (48) (47) Inflammation, Suppurative 1 (2%) Mineralization 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (1) (3) (1) Degeneration 1 (100%) 2 (67%) Cornea, Inflammation 1 (33%) 1 (100%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (49) (50) Amyloid Deposition 2 (4%) 2 (4%) Cyst 2 (4%) 1 (2%) Infiltration Cellular, Focal, Mixed Cell 1 (2%) Infiltration Cellular, Mast Cell 1 (2%) Inflammation, Chronic Active 2 (4%) Metaplasia, Osseous 5 (10%) 2 (4%) 1 (2%) Nephropathy 47 (94%) 40 (80%) 41 (84%) 41 (82%) Artery, Inflammation 5 (10%) 6 (12%) 2 (4%) Capsule, Hemorrhage 2 (4%) Capsule, Inflammation, Chronic 1 (2%) Glomerulus, Inflammation, Chronic 1 (2%) 1 (2%) Renal Tubule, Hyperplasia 5 (10%) 2 (4%) 3 (6%) 5 (10%) Urinary Bladder (50) (50) (48) (47) Angiectasis 1 (2%) Degeneration 1 (2%) Inflammation 1 (2%) Necrosis 1 (2%) Transitional Epithelium, Hyperplasia 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion 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