TDMS Study 88124-04 Pathology Tables
NTP Experiment-Test: 88124-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:17:14
FINAL#2, 2 YEAR CHRONIC
Facility: Battelle Northwest
Chemical CAS #: 22398-80-7
Lock Date: 10/02/98
Cage Range: All
Reasons For Removal: 25022 Accidently Killed 25019 Moribund Sacrifice
25020 Natural Death 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88124-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:17:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.03 0.1MG/M3 0.3MG/M3
MG/M3 STOP STOP
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Early Deaths
Accidently Killed 1 1
Moribund Sacrifice 4 31 15 18
Natural Death 3 6 2 10
Survivors
Terminal Sacrifice 42 13 33 21
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (46) (45) (48) (43)
Degeneration, Hyaline 1 (2%)
Inflammation, Suppurative 2 (4%) 2 (4%) 3 (6%)
Intestine Large, Rectum (47) (49) (50) (49)
Inflammation, Suppurative 1 (2%)
Intestine Small, Jejunum (46) (49) (49) (44)
Peyer's Patch, Hyperplasia 1 (2%)
Intestine Small, Ileum (46) (48) (50) (48)
Epithelium, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Peyer's Patch, Hyperplasia 2 (4%) 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 1 (2%) 2 (4%)
Basophilic Focus 2 (4%) 2 (4%) 2 (4%)
Clear Cell Focus 2 (4%) 2 (4%)
Eosinophilic Focus 6 (12%) 5 (10%) 4 (8%) 10 (20%)
Eosinophilic Focus, Multiple 4 (8%) 2 (4%)
Hematopoietic Cell Proliferation 3 (6%) 3 (6%) 4 (8%) 3 (6%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation 1 (2%) 1 (2%)
Karyomegaly 1 (2%)
Necrosis 4 (8%) 3 (6%) 9 (18%) 3 (6%)
Tension Lipidosis 2 (4%) 1 (2%) 2 (4%) 1 (2%)
Vacuolization Cytoplasmic 1 (2%) 1 (2%)
Bile Duct, Cyst 1 (2%)
Bile Duct, Degeneration, Hyaline 1 (2%)
Mesentery (13) (8) (8) (4)
Angiectasis 1 (8%)
Artery, Inflammation 4 (50%) 2 (25%) 1 (25%)
Fat, Necrosis 10 (77%) 3 (38%) 6 (75%) 3 (75%)
Pancreas (50) (49) (50) (50)
Atrophy 1 (2%) 1 (2%) 2 (4%)
Salivary Glands (49) (50) (50) (50)
Inflammation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88124-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:17:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.03 0.1MG/M3 0.3MG/M3
MG/M3 STOP STOP
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Stomach, Forestomach (50) (49) (50) (50)
Erosion 2 (4%)
Foreign Body 1 (2%)
Inflammation, Chronic 1 (2%)
Ulcer 2 (4%)
Epithelium, Hyperplasia 1 (2%) 4 (8%) 4 (8%) 3 (6%)
Stomach, Glandular (49) (49) (50) (49)
Inflammation, Suppurative 2 (4%) 1 (2%) 1 (2%)
Necrosis, Focal 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Tooth (1) (2)
Inflammation 2 (100%)
Malformation 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 45 (90%) 39 (78%) 46 (92%) 38 (76%)
Mineralization 2 (4%)
Necrosis 1 (2%)
Artery, Inflammation 1 (2%) 16 (32%) 11 (22%) 13 (26%)
Atrium, Thrombosis 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Epicardium, Inflammation 1 (2%) 5 (10%) 7 (14%)
Pericardium, Inflammation 9 (18%) 4 (8%)
Valve, Inflammation 1 (2%)
Valve, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Amyloid Deposition 2 (4%) 1 (2%) 2 (4%)
Degeneration, Cystic 1 (2%) 1 (2%)
Degeneration, Focal 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hyperplasia 1 (2%)
Hypertrophy 9 (18%) 7 (14%) 3 (6%) 10 (20%)
Capsule, Hyperplasia 1 (2%)
Adrenal Medulla (49) (49) (50) (49)
Hyperplasia 4 (8%) 5 (10%) 2 (4%) 3 (6%)
Islets, Pancreatic (50) (49) (50) (50)
Hyperplasia 2 (4%) 2 (4%) 1 (2%)
Parathyroid Gland (34) (31) (29) (30)
Hyperplasia 1 (3%)
Pituitary Gland (50) (50) (48) (49)
Pars Distalis, Hyperplasia 16 (32%) 15 (30%) 21 (44%) 15 (31%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88124-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:17:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.03 0.1MG/M3 0.3MG/M3
MG/M3 STOP STOP
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Intermedia, Hyperplasia 1 (2%)
Thyroid Gland (50) (49) (50) (49)
Inflammation, Suppurative 2 (4%) 4 (8%) 1 (2%)
Follicle, Cyst 1 (2%)
Follicular Cell, Hyperplasia 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (47) (46) (44) (47)
Angiectasis 2 (4%) 2 (4%) 1 (2%)
Cyst 12 (26%) 9 (20%) 11 (25%) 9 (19%)
Thrombosis 1 (2%) 1 (2%) 2 (4%)
Interstitial Cell, Hyperplasia 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Uterus (50) (49) (50) (50)
Angiectasis 1 (2%) 3 (6%) 3 (6%) 5 (10%)
Hydrometra 8 (16%) 8 (16%) 8 (16%) 5 (10%)
Hyperplasia, Cystic 38 (76%) 31 (63%) 36 (72%) 32 (64%)
Inflammation, Suppurative 1 (2%) 1 (2%) 1 (2%)
Mineralization 1 (2%)
Thrombosis 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Fibrosis 2 (4%) 1 (2%)
Hyperplasia 6 (12%) 13 (26%) 5 (10%) 7 (14%)
Lymph Node (1) (5) (6) (8)
Iliac, Angiectasis 1 (20%)
Iliac, Hematopoietic Cell Proliferation 1 (13%)
Iliac, Hyperplasia 1 (20%) 1 (13%)
Lumbar, Angiectasis 1 (17%)
Lumbar, Hemorrhage 1 (17%)
Lumbar, Hyperplasia 1 (20%) 1 (13%)
Lumbar, Inflammation, Chronic 1 (17%)
Renal, Angiectasis 1 (17%)
Lymph Node, Bronchial (36) (50) (48) (50)
Foreign Body 44 (88%) 33 (69%) 40 (80%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 5 (14%) 42 (84%) 31 (65%) 28 (56%)
Artery, Inflammation 2 (4%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88124-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:17:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.03 0.1MG/M3 0.3MG/M3
MG/M3 STOP STOP
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Lymph Node, Mandibular (36) (36) (43) (42)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 1 (2%)
Lymph Node, Mesenteric (48) (49) (50) (48)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hyperplasia 8 (17%) 6 (12%) 7 (14%) 7 (15%)
Inflammation, Chronic Active 1 (2%)
Lymph Node, Mediastinal (42) (48) (46) (49)
Foreign Body 20 (42%) 7 (15%) 16 (33%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 2 (5%) 40 (83%) 11 (24%) 29 (59%)
Spleen (50) (49) (50) (49)
Hematopoietic Cell Proliferation 16 (32%) 36 (73%) 26 (52%) 21 (43%)
Hyperplasia, Lymphoid 15 (30%) 3 (6%) 11 (22%) 14 (29%)
Metaplasia, Osseous 1 (2%)
Thymus (47) (46) (42) (42)
Hyperplasia, Lymphoid 3 (7%) 3 (7%) 2 (5%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Hyperplasia 2 (4%) 2 (4%) 4 (8%) 3 (6%)
Metaplasia, Squamous 1 (2%)
Skin (50) (50) (50) (50)
Hyperplasia 1 (2%)
Inflammation, Suppurative 2 (4%) 1 (2%)
Hair Follicle, Atrophy 1 (2%)
Subcutaneous Tissue, Angiectasis 1 (2%)
Subcutaneous Tissue, Hemorrhage 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic
Active 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Cyst 1 (2%)
Fibrous Osteodystrophy 11 (22%) 14 (28%) 14 (28%) 16 (32%)
Inflammation, Chronic 1 (2%)
Maxilla, Fracture 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88124-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:17:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.03 0.1MG/M3 0.3MG/M3
MG/M3 STOP STOP
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Meninges, Infiltration Cellular, Mononuclear
Cell 2 (4%) 2 (4%) 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (50) (50)
Inflammation, Suppurative 1 (2%) 1 (2%) 2 (4%)
Squamous Epithelium, Hyperplasia 9 (18%) 17 (34%) 10 (20%) 15 (30%)
Lung (50) (50) (50) (50)
Foreign Body 49 (98%) 35 (70%) 49 (98%)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 4 (8%) 3 (6%) 4 (8%) 4 (8%)
Inflammation, Chronic Active 2 (4%) 49 (98%) 45 (90%) 50 (100%)
Thrombosis 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%) 1 (2%) 2 (4%)
Alveolus, Infiltration Cellular, Histiocyte 2 (4%) 2 (4%) 3 (6%)
Alveolus, Proteinosis 31 (62%) 8 (16%)
Artery, Inflammation 1 (2%) 1 (2%)
Artery, Mediastinum, Inflammation 1 (2%)
Bronchiole, Bronchus, Degeneration, Hyaline 2 (4%)
Interstitium, Fibrosis 1 (2%) 2 (4%)
Mediastinum, Inflammation, Chronic Active 1 (2%)
Perivascular, Infiltration Cellular,
Mononuclear Cell 1 (2%)
Serosa, Fibrosis 50 (100%) 47 (94%) 49 (98%)
Serosa, Metaplasia, Osseous 1 (2%)
Nose (50) (50) (50) (50)
Angiectasis 1 (2%)
Inflammation, Suppurative 7 (14%) 7 (14%) 7 (14%) 2 (4%)
Olfactory Epithelium, Atrophy 6 (12%) 1 (2%) 3 (6%) 2 (4%)
Olfactory Epithelium, Degeneration, Hyaline 3 (6%) 3 (6%) 10 (20%) 2 (4%)
Respiratory Epithelium, Degeneration, Hyaline 28 (56%) 17 (34%) 27 (54%) 14 (28%)
Respiratory Epithelium, Hyperplasia 1 (2%)
Pleura (16) (3) (13)
Mesothelium, Hyperplasia 16 (100%) 3 (100%) 13 (100%)
Trachea (50) (48) (50) (50)
Degeneration, Hyaline 1 (2%)
Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88124-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:17:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.03 0.1MG/M3 0.3MG/M3
MG/M3 STOP STOP
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1)
Degeneration 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49) (50) (50)
Cyst 1 (2%)
Inflammation, Chronic Active 1 (2%)
Metaplasia, Osseous 2 (4%) 3 (6%) 4 (8%) 2 (4%)
Nephropathy 37 (74%) 30 (61%) 43 (86%) 36 (72%)
Artery, Inflammation 1 (2%) 3 (6%)
Glomerulus, Inflammation, Chronic 1 (2%)
Renal Tubule, Karyomegaly 1 (2%)
Urinary Bladder (48) (49) (49) (48)
Angiectasis 2 (4%) 1 (2%) 3 (6%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88124-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:17:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.03 0.1MG/M3 0.3MG/M3
MG/M3 STOP STOP
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Early Deaths
Natural Death 8 11 9 11
Moribund Sacrifice 5 14 12 12
Accidently Killed 1
Survivors
Terminal Sacrifice 37 24 29 27
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (43) (43) (41) (38)
Degeneration, Hyaline 1 (2%) 2 (5%)
Inflammation, Chronic 1 (3%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Intestine Large, Colon (49) (48) (48) (46)
Inflammation, Chronic 1 (2%) 1 (2%)
Intestine Large, Cecum (47) (47) (46) (46)
Inflammation, Suppurative 1 (2%)
Intestine Small, Jejunum (47) (44) (46) (44)
Fibrosis 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%)
Intestine Small, Ileum (45) (47) (43) (45)
Amyloid Deposition 1 (2%)
Artery, Inflammation 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Peyer's Patch, Hyperplasia 5 (11%) 1 (2%)
Liver (50) (50) (50) (50)
Amyloid Deposition 2 (4%)
Angiectasis 1 (2%)
Basophilic Focus 2 (4%) 1 (2%) 2 (4%)
Clear Cell Focus 1 (2%) 1 (2%)
Clear Cell Focus, Multiple 1 (2%) 2 (4%)
Eosinophilic Focus 9 (18%) 15 (30%) 14 (28%) 10 (20%)
Eosinophilic Focus, Multiple 1 (2%) 1 (2%) 5 (10%) 8 (16%)
Hematopoietic Cell Proliferation 1 (2%)
Inflammation, Chronic Active 1 (2%)
Inflammation, Focal, Granulomatous 1 (2%) 1 (2%)
Mixed Cell Focus 1 (2%) 1 (2%)
Necrosis 4 (8%) 4 (8%) 2 (4%) 7 (14%)
Tension Lipidosis 2 (4%) 1 (2%)
Vacuolization Cytoplasmic 2 (4%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88124-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:17:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.03 0.1MG/M3 0.3MG/M3
MG/M3 STOP STOP
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Mesentery (4) (5) (5) (8)
Artery, Inflammation 4 (80%) 1 (20%) 1 (13%)
Fat, Inflammation 1 (13%)
Fat, Necrosis 4 (100%) 1 (20%) 4 (80%) 4 (50%)
Pancreas (50) (50) (49) (47)
Atrophy 3 (6%) 2 (4%) 2 (4%)
Hypertrophy 2 (4%)
Artery, Inflammation 1 (2%)
Duct, Cyst 1 (2%) 1 (2%)
Stomach, Forestomach (49) (50) (48) (50)
Erosion 2 (4%)
Infiltration Cellular 1 (2%)
Infiltration Cellular, Mast Cell 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%)
Ulcer 1 (2%) 2 (4%) 3 (6%) 1 (2%)
Artery, Inflammation 1 (2%)
Epithelium, Hyperplasia 2 (4%) 6 (12%) 8 (17%) 5 (10%)
Stomach, Glandular (49) (49) (48) (47)
Infiltration Cellular 1 (2%)
Inflammation, Suppurative 1 (2%) 2 (4%) 2 (4%)
Necrosis, Focal 1 (2%) 1 (2%) 1 (2%)
Epithelium, Hyperplasia 1 (2%) 1 (2%)
Tooth (2) (1) (2)
Inflammation 2 (100%) 1 (100%)
Malformation 2 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (2) (1)
Inflammation 1 (100%)
Mineralization 1 (100%)
Aorta, Aneurysm 1 (50%)
Aorta, Hemorrhage 1 (50%)
Aorta, Inflammation 1 (50%)
Aorta, Mineralization 1 (50%)
Aorta, Necrosis 1 (50%)
Heart (50) (50) (50) (50)
Cardiomyopathy 39 (78%) 41 (82%) 42 (84%) 41 (82%)
Hemorrhage 1 (2%)
Mineralization 2 (4%) 1 (2%)
Artery, Inflammation 3 (6%) 18 (36%) 14 (28%) 10 (20%)
Artery, Mineralization 1 (2%)
Atrium, Inflammation, Chronic 1 (2%) 1 (2%)
Atrium, Metaplasia, Osseous 1 (2%)
Atrium, Thrombosis 1 (2%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88124-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:17:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.03 0.1MG/M3 0.3MG/M3
MG/M3 STOP STOP
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - CONT
Epicardium, Inflammation 2 (4%) 1 (2%)
Pericardium, Inflammation 6 (12%) 5 (10%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (48) (50)
Amyloid Deposition 2 (4%)
Angiectasis 1 (2%)
Degeneration, Focal 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Hypertrophy 30 (60%) 15 (30%) 23 (48%) 19 (38%)
Necrosis 1 (2%)
Adrenal Medulla (50) (50) (48) (49)
Hyperplasia 3 (6%) 2 (4%) 1 (2%) 6 (12%)
Islets, Pancreatic (50) (50) (49) (47)
Hyperplasia 8 (16%) 1 (2%) 3 (6%) 4 (9%)
Parathyroid Gland (33) (30) (34) (34)
Amyloid Deposition 1 (3%)
Pituitary Gland (48) (47) (45) (50)
Pars Distalis, Hyperplasia 1 (2%) 1 (2%)
Pars Intermedia, Hyperplasia 1 (2%) 1 (2%)
Thyroid Gland (47) (48) (47) (50)
Amyloid Deposition 2 (4%)
Follicle, Degeneration, Cystic 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Granuloma Sperm 2 (4%) 2 (4%)
Inflammation 1 (2%) 1 (2%) 2 (4%)
Preputial Gland (50) (50) (50) (49)
Ectasia 25 (50%) 21 (42%) 19 (38%) 20 (41%)
Hyperplasia, Squamous 1 (2%)
Inflammation 5 (10%) 3 (6%)
Prostate (50) (49) (48) (48)
Inflammation, Suppurative 1 (2%)
Seminal Vesicle (49) (47) (48) (47)
Congestion 1 (2%)
Testes (50) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88124-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:17:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.03 0.1MG/M3 0.3MG/M3
MG/M3 STOP STOP
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Angiectasis 1 (2%)
Atrophy 6 (12%) 1 (2%) 2 (4%) 2 (4%)
Inflammation, Granulomatous 1 (2%)
Interstitial Cell, Hyperplasia 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (50) (50) (50)
Hyperplasia 5 (10%) 9 (18%) 6 (12%) 4 (8%)
Lymph Node, Bronchial (35) (48) (45) (48)
Foreign Body 43 (90%) 40 (89%) 40 (83%)
Hyperplasia 2 (6%) 36 (75%) 22 (49%) 22 (46%)
Artery, Inflammation 1 (2%)
Lymph Node, Mandibular (28) (32) (33) (36)
Hyperplasia 1 (4%) 2 (6%) 1 (3%)
Lymph Node, Mesenteric (48) (47) (49) (45)
Angiectasis 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia 11 (23%) 2 (4%) 10 (20%) 10 (22%)
Inflammation, Granulomatous 2 (4%)
Artery, Inflammation 1 (2%)
Lymph Node, Mediastinal (40) (49) (45) (48)
Foreign Body 24 (49%) 14 (31%) 25 (52%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hyperplasia 34 (69%) 17 (38%) 27 (56%)
Infiltration Cellular, Histiocyte 1 (2%)
Artery, Inflammation 1 (2%) 2 (4%) 1 (2%)
Spleen (50) (50) (48) (48)
Amyloid Deposition 2 (4%)
Angiectasis 2 (4%) 2 (4%)
Hematopoietic Cell Proliferation 14 (28%) 34 (68%) 23 (48%) 29 (60%)
Hyperplasia, Lymphoid 3 (6%) 4 (8%) 3 (6%)
Thymus (35) (39) (41) (35)
Epithelial Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (50)
Hyperplasia 2 (4%) 1 (2%) 2 (4%)
Inflammation, Suppurative 1 (2%) 3 (6%)
Mineralization 1 (2%)
Ulcer 1 (2%)
Prepuce, Inflammation, Chronic Active 1 (2%) 2 (4%) 3 (6%) 3 (6%)
Subcutaneous Tissue, Edema 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88124-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:17:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.03 0.1MG/M3 0.3MG/M3
MG/M3 STOP STOP
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (49) (50) (50)
Fibrous Osteodystrophy 2 (4%) 2 (4%) 2 (4%)
Hyperplasia 1 (2%)
Maxilla, Fracture 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Degeneration 1 (2%)
Developmental Malformation 1 (2%)
Meninges, Infiltration Cellular, Mononuclear
Cell 2 (4%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (49) (49) (50)
Inflammation, Suppurative 5 (10%) 3 (6%) 1 (2%) 4 (8%)
Epiglottis, Metaplasia, Squamous 1 (2%)
Squamous Epithelium, Hyperplasia 6 (12%) 3 (6%) 4 (8%) 7 (14%)
Lung (50) (50) (50) (50)
Foreign Body 49 (98%) 42 (84%) 49 (98%)
Hemorrhage 5 (10%) 1 (2%) 2 (4%) 2 (4%)
Infiltration Cellular, Mast Cell 1 (2%)
Inflammation, Chronic Active 2 (4%) 50 (100%) 45 (90%) 46 (92%)
Inflammation, Suppurative 1 (2%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (4%) 5 (10%) 3 (6%) 7 (14%)
Alveolus, Infiltration Cellular, Histiocyte 1 (2%)
Alveolus, Proteinosis 14 (28%) 10 (20%)
Artery, Mediastinum, Inflammation 2 (4%) 2 (4%)
Bronchiole, Hyperplasia 1 (2%)
Interstitium, Fibrosis 2 (4%)
Serosa, Cyst 1 (2%)
Serosa, Fibrosis 50 (100%) 49 (98%) 50 (100%)
Serosa, Metaplasia, Osseous 1 (2%)
Nose (49) (50) (49) (50)
Foreign Body 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Suppurative 3 (6%) 5 (10%) 4 (8%) 5 (10%)
Olfactory Epithelium, Atrophy 2 (4%) 4 (8%) 2 (4%) 1 (2%)
Olfactory Epithelium, Degeneration, Hyaline 1 (2%)
Respiratory Epithelium, Degeneration, Hyaline 5 (10%) 2 (4%) 3 (6%) 4 (8%)
Pleura (19) (4) (6)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88124-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:17:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.03 0.1MG/M3 0.3MG/M3
MG/M3 STOP STOP
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Mesothelium, Hyperplasia 19 (100%) 4 (100%) 6 (100%)
Trachea (48) (46) (48) (47)
Inflammation, Suppurative 1 (2%)
Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (3) (1)
Degeneration 1 (100%) 2 (67%)
Cornea, Inflammation 1 (33%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (49) (50)
Amyloid Deposition 2 (4%) 2 (4%)
Cyst 2 (4%) 1 (2%)
Infiltration Cellular, Focal, Mixed Cell 1 (2%)
Infiltration Cellular, Mast Cell 1 (2%)
Inflammation, Chronic Active 2 (4%)
Metaplasia, Osseous 5 (10%) 2 (4%) 1 (2%)
Nephropathy 47 (94%) 40 (80%) 41 (84%) 41 (82%)
Artery, Inflammation 5 (10%) 6 (12%) 2 (4%)
Capsule, Hemorrhage 2 (4%)
Capsule, Inflammation, Chronic 1 (2%)
Glomerulus, Inflammation, Chronic 1 (2%) 1 (2%)
Renal Tubule, Hyperplasia 5 (10%) 2 (4%) 3 (6%) 5 (10%)
Urinary Bladder (50) (50) (48) (47)
Angiectasis 1 (2%)
Degeneration 1 (2%)
Inflammation 1 (2%)
Necrosis 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
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