TDMS Study 88124-04 Pathology Tables
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
FINAL#2, 2 YEAR CHRONIC
Facility: Battelle Northwest
Chemical CAS #: 22398-80-7
Lock Date: 10/02/98
Cage Range: All
Reasons For Removal: 25022 Accidently Killed 25019 Moribund Sacrifice
25020 Natural Death 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 9|
| 7| 7| 6| 7| 6| 7| 7| 4| 6| 7| 6| 6| 6| 5| 4| 5| 6| 5| 7| 7| 6| 5| 7| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M + + + + + + + + + + + + + + A + + + + + + + + A|
Inflammation, Suppurative | 1 1 |
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + A + + + + + + + + A|
Peyer's Patch, Hyperplasia | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + A + + + + + + + + A|
Epithelium, Hyperplasia | |
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X X |
Eosinophilic Focus | |
Hematopoietic Cell Proliferation | 1 |
Hyperplasia, Lymphoid | |
Karyomegaly | |
Necrosis | 1 1 |
Tension Lipidosis | X |
Vacuolization Cytoplasmic | 1 |
Bile Duct, Cyst | 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + +|
Angiectasis | 3|
Fat, Necrosis | 2 2 2 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Tooth | + |
Malformation | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 |
Artery, Inflammation | 1|
Atrium, Thrombosis | 2|
Epicardium, Inflammation | |
Valve, Thrombosis | 4|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 9|
| 7| 7| 6| 7| 6| 7| 7| 4| 6| 7| 6| 6| 6| 5| 4| 5| 6| 5| 7| 7| 6| 5| 7| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Degeneration, Cystic | 2 |
Hematopoietic Cell Proliferation | |
Hypertrophy | 1 1 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + M + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + M + M + + + M + + + + + + M +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 4 1 1 1 1 2 |
Pars Intermedia, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 3 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + + + + + + + + + + M M + + + + + + + M + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Cyst | 1 3 2 3 2 1 |
Interstitial Cell, Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hydrometra | 2 2 4 2 3 2 |
Hyperplasia, Cystic | 2 2 2 2 4 1 2 3 1 4 3 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M M + + M M M + + + M + + + M + + + + M + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + M + + + + + + + M M + + + M + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 9|
| 7| 7| 6| 7| 6| 7| 7| 4| 6| 7| 6| 6| 6| 5| 4| 5| 6| 5| 7| 7| 6| 5| 7| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + M M M + M + + M + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 1 2 1 1 2|
Hyperplasia, Lymphoid | 2 2 2 2 3 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + I + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 1 1 3 2 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Infiltration Cellular, | |
Mononuclear Cell | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Epithelium, Hyperplasia | 1 1 1 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 1 1 |
Inflammation, Chronic Active | 2 |
Mediastinum, Inflammation, Chronic | |
Active | |
Perivascular, Infiltration Cellular, | |
Mononuclear Cell | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Inflammation, Suppurative | 1 1 1|
Olfactory Epithelium, Atrophy | 1 1 2 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 1 1 1 2 1 1 2 1 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 9|
| 7| 7| 6| 7| 6| 7| 7| 4| 6| 7| 6| 6| 6| 5| 4| 5| 6| 5| 7| 7| 6| 5| 7| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Suppurative | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1|
Metaplasia, Osseous | 1 1 |
Nephropathy | 1 2 1 1 1 3 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | A + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| |
| 7| 7| 6| 6| 5| 6| 7| 6| 6| 6| 5| 9| 6| 6| 6| 7| 5| 5| 6| 7| 8| 6| 5| 7| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + M + + + + + + + + + + + + + + + + + + + + + +| 46 |
Inflammation, Suppurative | | 2 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + + + +| 46 |
Peyer's Patch, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + + + + + +| 46 |
Epithelium, Hyperplasia | 2 | 1 2.0|
Peyer's Patch, Hyperplasia | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 2 |
Clear Cell Focus | | 2 |
Eosinophilic Focus | X X X X X X | 6 |
Hematopoietic Cell Proliferation | 3 1 | 3 1.7|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Karyomegaly | 1 | 1 1.0|
Necrosis | 1 1 | 4 1.0|
Tension Lipidosis | X | 2 |
Vacuolization Cytoplasmic | | 1 1.0|
Bile Duct, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 13 |
Angiectasis | | 1 3.0|
Fat, Necrosis | 2 3 3 2 2 | 10 2.6|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 2 | 2 1.5|
__________________________________________________________________________|____________|
Tooth | | 1 |
Malformation | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 45 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| |
| 7| 7| 6| 6| 5| 6| 7| 6| 6| 6| 5| 9| 6| 6| 6| 7| 5| 5| 6| 7| 8| 6| 5| 7| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Artery, Inflammation | | 1 1.0|
Atrium, Thrombosis | | 1 2.0|
Epicardium, Inflammation | 2 | 1 2.0|
Valve, Thrombosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | 2 2 | 2 2.0|
Degeneration, Cystic | | 1 2.0|
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hypertrophy | 1 1 1 1 1 | 9 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 1 1 | 4 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________|____________|
Parathyroid Gland | M M + M + + + + M + + M M + M M M + + + M + + + M| 34 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Hyperplasia | 2 2 3 2 3 4 1 2 1 2 | 16 2.0|
Pars Intermedia, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicle, Cyst | | 1 3.0|
Follicular Cell, Hyperplasia | 2| 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + M + + + + + + + + + M + + + M + +| 47 |
Angiectasis | 2 | 2 3.0|
Cyst | 2 1 2 2 4 2| 12 2.1|
Interstitial Cell, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 1 1.0|
Hydrometra | 2 3 | 8 2.5|
Hyperplasia, Cystic | 4 3 2 3 2 1 2 2 2 2 2 2 2 2 2 2 3 3 4 1 3| 38 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| |
| 7| 7| 6| 6| 5| 6| 7| 6| 6| 6| 5| 9| 6| 6| 6| 7| 5| 5| 6| 7| 8| 6| 5| 7| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 1 1 | 2 1.0|
Hyperplasia | 2 2 3 2 3 | 6 2.3|
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + + M + + + M + + + M M + + + + + + M + + +| 36 |
Hyperplasia | 2 2 3| 5 1.8|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + + + M + M M + + M M M + + + M M + + +| 36 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M + + + + + + + M + + + + + + + + + + + + + +| 48 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia | 2 2 2 2 2 1 2 | 8 1.9|
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M + + + + + + + + + + + + M + + + + M + + + +| 42 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 1 1 1 3 1 1 2 3 3 | 16 1.6|
Hyperplasia, Lymphoid | 2 2 4 2 2 2 2 2| 15 2.2|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + + + + + + + + + + + + M + + +| 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 1 1 1 1 | 11 1.5|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Meninges, Infiltration Cellular, | | |
Mononuclear Cell | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Squamous Epithelium, Hyperplasia | 2 1 1 1 1| 9 1.1|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| |
| 7| 7| 6| 6| 5| 6| 7| 6| 6| 6| 5| 9| 6| 6| 6| 7| 5| 5| 6| 7| 8| 6| 5| 7| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Hemorrhage | | 4 1.0|
Inflammation, Chronic Active | 3 | 2 2.5|
Mediastinum, Inflammation, Chronic | | |
Active | 3 | 1 3.0|
Perivascular, Infiltration Cellular, | | |
Mononuclear Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 1 1.0|
Inflammation, Suppurative | 1 2 1 1 | 7 1.1|
Olfactory Epithelium, Atrophy | 1 1 1 | 6 1.2|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 1 | 3 1.3|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1 | 28 1.2|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 1.0|
Metaplasia, Osseous | | 2 1.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 37 1.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + A + + + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | 1 | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 7| 7| 6| 6| 5| 7| 7| 7| 6| 4| 6| 6| 6| 6| 7| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 2| 5| 3| 8| 1| 3| 1| 5| 8| 0| 3| 3| 8| 2| 8| 7| 4| 7| 3| 3| 3| 3| 8| 8|
| 7| 7| 9| 7| 9| 5| 2| 7| 3| 9| 0| 5| 5| 7| 6| 8| 4| 5| 4| 7| 6| 6| 5| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.03 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + A + + + A + + + + + + + + + + + + + + + +|
Degeneration, Hyaline | 1 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + A + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + A + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Eosinophilic Focus | X X X |
Eosinophilic Focus, Multiple | X X X |
Hematopoietic Cell Proliferation | 1 |
Inflammation | |
Necrosis | 1 |
Tension Lipidosis | X|
__________________________________________________________________________|
Mesentery | + + + + |
Artery, Inflammation | 3 |
Fat, Necrosis | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + A + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 2|
Epithelium, Hyperplasia | 3 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 |
Artery, Inflammation | 1 2 2 2 1 2 |
Atrium, Thrombosis | |
Epicardium, Inflammation | 3 |
Pericardium, Inflammation | 1 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1 |
Hypertrophy | 1 1 2 1 1 |
Capsule, Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + A + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 7| 7| 6| 6| 5| 7| 7| 7| 6| 4| 6| 6| 6| 6| 7| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 2| 5| 3| 8| 1| 3| 1| 5| 8| 0| 3| 3| 8| 2| 8| 7| 4| 7| 3| 3| 3| 3| 8| 8|
| 7| 7| 9| 7| 9| 5| 2| 7| 3| 9| 0| 5| 5| 7| 6| 8| 4| 5| 4| 7| 6| 6| 5| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.03 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + I + M + M + + M M + + + + + M + + M + M M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 3 3 1 2 1 1 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + A + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + + + + + + + + + + + M M + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + A + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 |
Cyst | 1 2 3 2 |
Thrombosis | |
Interstitial Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Uterus | + + + + A + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 2 |
Hydrometra | 3 3 4 4 4 |
Hyperplasia, Cystic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Inflammation, Suppurative | 2 |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 1 1 1 2 3 2 |
__________________________________________________________________________|
Lymph Node | + + + + |
Iliac, Angiectasis | 2 |
Iliac, Hyperplasia | 2 |
Lumbar, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Hyperplasia | 3 3 2 3 4 4 2 2 3 3 4 3 3 2 2 2 2 4 2 4 3 2|
Artery, Inflammation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | M M + M M + + + + + + + + + M + + M + + + M + M +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + A + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + + + + + + + + + + + + M + + + + + + + + +|
Foreign Body | 1 1 1 1 1 1 1 1 1 |
Hyperplasia | 4 2 3 4 4 2 2 3 2 4 3 4 3 2 2 2 2 4 3 3 2|
__________________________________________________________________________|
Spleen | + + + + A + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 2 2 2 3 1 3 3 2 2 2 2 2 2 2 3 2 2 1 3 |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 7| 7| 6| 6| 5| 7| 7| 7| 6| 4| 6| 6| 6| 6| 7| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 2| 5| 3| 8| 1| 3| 1| 5| 8| 0| 3| 3| 8| 2| 8| 7| 4| 7| 3| 3| 3| 3| 8| 8|
| 7| 7| 9| 7| 9| 5| 2| 7| 3| 9| 0| 5| 5| 7| 6| 8| 4| 5| 4| 7| 6| 6| 5| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.03 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + + + M + + + + + +|
Hyperplasia, Lymphoid | 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Metaplasia, Squamous | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Subcutaneous Tissue, Angiectasis | 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Fibrous Osteodystrophy | 1 1 1 2 1 2 1 1 3 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Infiltration Cellular, | |
Mononuclear Cell | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
Squamous Epithelium, Hyperplasia | 1 1 1 2 1 1 1 1 2|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X X X X X X X X X X X X X X X X X X X X X X X|
Hemorrhage | 1 1 |
Inflammation, Chronic Active | 3 4 3 3 2 3 2 3 3 3 3 3 3 2 4 3 3 3 3 2 2 3 3 3 2|
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Alveolus, Proteinosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Artery, Inflammation | |
Interstitium, Fibrosis | 1 |
Serosa, Fibrosis | 4 4 3 4 3 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4 3 4 3 4 3|
Serosa, Metaplasia, Osseous | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 2 1 |
Olfactory Epithelium, Atrophy | |
Olfactory Epithelium, Degeneration, | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 7| 7| 6| 6| 5| 7| 7| 7| 6| 4| 6| 6| 6| 6| 7| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 2| 5| 3| 8| 1| 3| 1| 5| 8| 0| 3| 3| 8| 2| 8| 7| 4| 7| 3| 3| 3| 3| 8| 8|
| 7| 7| 9| 7| 9| 5| 2| 7| 3| 9| 0| 5| 5| 7| 6| 8| 4| 5| 4| 7| 6| 6| 5| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.03 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hyaline | 1 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 1 2 1 1 1 1 1 |
__________________________________________________________________________|
Pleura | + + + + + + |
Mesothelium, Hyperplasia | 1 2 1 1 4 1 |
__________________________________________________________________________|
Trachea | + + + + A + + + I + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + A + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Osseous | 2 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + A + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 5| 6| 7| 6| 6| 5| 5| 6| 6| 6| 6| 5| 5| 6| 7| 7| 7| 5| 7| 5| 6| 6| |
DAY ON TEST | 1| 3| 8| 3| 5| 3| 8| 4| 8| 3| 1| 8| 8| 4| 3| 3| 7| 3| 3| 0| 1| 3| 4| 4| 3| |
| 4| 7| 7| 3| 7| 5| 8| 5| 9| 3| 7| 6| 6| 5| 3| 3| 1| 6| 6| 6| 4| 7| 8| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0.03 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + M + M + + + + + + + + + + + + + + + + A| 45 |
Degeneration, Hyaline | | 1 1.0|
Inflammation, Suppurative | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X | 2 |
Eosinophilic Focus | X X| 5 |
Eosinophilic Focus, Multiple | X | 4 |
Hematopoietic Cell Proliferation | 4 1 | 3 2.0|
Inflammation | 2 | 1 2.0|
Necrosis | 1 1 | 3 1.0|
Tension Lipidosis | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + + | 8 |
Artery, Inflammation | 4 3 1 | 4 2.8|
Fat, Necrosis | 3 | 3 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ulcer | | 2 2.0|
Epithelium, Hyperplasia | 1 2 | 4 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1| 39 1.1|
Artery, Inflammation | 2 1 2 4 1 3 1 2 1 2 | 16 1.8|
Atrium, Thrombosis | 3 | 1 3.0|
Epicardium, Inflammation | 1 2 2 2 | 5 2.0|
Pericardium, Inflammation | 1 3 3 2 2 2 | 9 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 5| 6| 7| 6| 6| 5| 5| 6| 6| 6| 6| 5| 5| 6| 7| 7| 7| 5| 7| 5| 6| 6| |
DAY ON TEST | 1| 3| 8| 3| 5| 3| 8| 4| 8| 3| 1| 8| 8| 4| 3| 3| 7| 3| 3| 0| 1| 3| 4| 4| 3| |
| 4| 7| 7| 3| 7| 5| 8| 5| 9| 3| 7| 6| 6| 5| 3| 3| 1| 6| 6| 6| 4| 7| 8| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0.03 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Amyloid Deposition | | 1 1.0|
Hypertrophy | 2 1 | 7 1.3|
Capsule, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 2 | 5 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M M + + + + M + M + M + M M M + + M + + +| 31 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Hyperplasia | 2 2 1 1 2 3 | 15 1.9|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + M + + + + M + M + + M M + + + + + + M M + + +| 40 |
__________________________________________________________________________|____________|
Ovary | M + M + I + + + + + + + + + + + + + + + + + + + +| 46 |
Angiectasis | | 2 1.5|
Cyst | 2 1 2 3 2| 9 2.0|
Thrombosis | 3 | 1 3.0|
Interstitial Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 3 1.7|
Hydrometra | 1 3 2 | 8 3.0|
Hyperplasia, Cystic | 1 1 1 3 2 2 4 1 2 2 1 1 2 2 | 31 1.9|
Inflammation, Suppurative | | 1 2.0|
Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 3 | 13 1.9|
__________________________________________________________________________|____________|
Lymph Node | + | 5 |
Iliac, Angiectasis | | 1 2.0|
Iliac, Hyperplasia | | 1 2.0|
Lumbar, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 44 1.0|
Hyperplasia | 4 2 4 2 3 2 3 4 2 4 3 3 3 2 4 3 3 2 2 2| 42 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 5| 6| 7| 6| 6| 5| 5| 6| 6| 6| 6| 5| 5| 6| 7| 7| 7| 5| 7| 5| 6| 6| |
DAY ON TEST | 1| 3| 8| 3| 5| 3| 8| 4| 8| 3| 1| 8| 8| 4| 3| 3| 7| 3| 3| 0| 1| 3| 4| 4| 3| |
| 4| 7| 7| 3| 7| 5| 8| 5| 9| 3| 7| 6| 6| 5| 3| 3| 1| 6| 6| 6| 4| 7| 8| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0.03 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Artery, Inflammation | 3 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M M M + + + + + + M M M + + + + + + + + +| 36 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 4 4 | 6 2.7|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Foreign Body | 1 1 1 1 1 1 1 1 1 1 1 | 20 1.0|
Hyperplasia | 4 4 3 4 2 2 4 2 4 3 3 3 4 3 3 3 3 2 3| 40 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 2 4 2 2 2 3 2 2 3 2 2 2 2 1 2 2 | 36 2.1|
Hyperplasia, Lymphoid | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + M + + + M + + + + + + + + +| 46 |
Hyperplasia, Lymphoid | | 3 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 2 2.0|
Metaplasia, Squamous | | 1 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 3 4 | 2 3.5|
Subcutaneous Tissue, Angiectasis | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 3.0|
Fibrous Osteodystrophy | 1 2 2 1 1 | 14 1.4|
Inflammation, Chronic | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Meninges, Infiltration Cellular, | | |
Mononuclear Cell | 1| 2 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 1.0|
Squamous Epithelium, Hyperplasia | 1 1 1 1 1 1 1 2 | 17 1.2|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 5| 6| 7| 6| 6| 5| 5| 6| 6| 6| 6| 5| 5| 6| 7| 7| 7| 5| 7| 5| 6| 6| |
DAY ON TEST | 1| 3| 8| 3| 5| 3| 8| 4| 8| 3| 1| 8| 8| 4| 3| 3| 7| 3| 3| 0| 1| 3| 4| 4| 3| |
| 4| 7| 7| 3| 7| 5| 8| 5| 9| 3| 7| 6| 6| 5| 3| 3| 1| 6| 6| 6| 4| 7| 8| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0.03 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Foreign Body | X X X X X X X X X X 1 X X X X X X X X X X X X X X| 49 1.0|
Hemorrhage | 1 | 3 1.0|
Inflammation, Chronic Active | 2 2 4 2 3 3 3 4 3 2 3 3 3 4 4 3 3 2 2 4 2 4 2 3| 49 2.9|
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 2 | 2 2.0|
Alveolus, Proteinosis | 1 1 2 1 1 1 1 1 2 1 1 1 1 1 1 | 31 1.1|
Artery, Inflammation | 4 | 1 4.0|
Interstitium, Fibrosis | | 1 1.0|
Serosa, Fibrosis | 4 3 3 3 4 4 4 4 4 4 4 4 4 4 4 4 4 3 4 4 4 3 4 4 4| 50 3.8|
Serosa, Metaplasia, Osseous | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 1 1 | 7 1.1|
Olfactory Epithelium, Atrophy | 1 | 1 1.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 | 3 1.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 1 1 1 1 1 1 | 17 1.1|
__________________________________________________________________________|____________|
Pleura | + + + + + + + + + +| 16 |
Mesothelium, Hyperplasia | 4 1 1 1 1 3 1 2 2 2| 16 1.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Metaplasia, Osseous | 1 1 | 3 1.3|
Nephropathy | 1 1 1 1 2 1 1 3 1 1 1 1 1 1 1 | 30 1.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
_____________________________________________________________________________________________________________________
| 6| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 8| 2| 4| 6| 3| 3| 3| 3| 3| 8| 3| 9| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 8| 3| 3|
| 7| 9| 7| 4| 6| 6| 6| 7| 5| 1| 6| 1| 6| 7| 7| 7| 7| 7| 7| 6| 6| 5| 9| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.1MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Eosinophilic Focus | X X |
Hematopoietic Cell Proliferation | 2 3 2 |
Inflammation | 2 |
Necrosis | 3 1 3 1 2 1 |
Tension Lipidosis | X X |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Mesentery | + + + + + + |
Artery, Inflammation | 2 |
Fat, Necrosis | 2 2 3 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Epithelium, Hyperplasia | 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Tooth | + |
Inflammation | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 2 3 1 1 1 1 1 1 1 2 2 1 1 2|
Mineralization | 1 |
Artery, Inflammation | 3 2 2 2 1 2|
Atrium, Thrombosis | 2 |
Valve, Inflammation | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
_____________________________________________________________________________________________________________________
| 6| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 8| 2| 4| 6| 3| 3| 3| 3| 3| 8| 3| 9| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 8| 3| 3|
| 7| 9| 7| 4| 6| 6| 6| 7| 5| 1| 6| 1| 6| 7| 7| 7| 7| 7| 7| 6| 6| 5| 9| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.1MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 |
Hematopoietic Cell Proliferation | 1 |
Hypertrophy | 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + M M M + + + + + M M M M + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 2 2 2 1 1 2 2 1 2 1 1 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 2|
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + M + + + + + + + M + + + + M + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + M + + + I + + + + + + + + + + + M|
Cyst | 2 2 2 4 1 2 |
Thrombosis | 4 |
Interstitial Cell, Hyperplasia | |
__________________________________________________________________________|
Oviduct | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hydrometra | 2 2 4 2 |
Hyperplasia, Cystic | 2 2 1 2 2 2 3 1 2 2 3 3 2 1 1 1 1 1|
Inflammation, Suppurative | 4 |
Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hyperplasia | 3 3 2 2|
__________________________________________________________________________|
Lymph Node | + + + + |
Lumbar, Angiectasis | |
Lumbar, Hemorrhage | |
Lumbar, Inflammation, Chronic | |
Renal, Angiectasis | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + M +|
Foreign Body | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Hyperplasia | 3 2 2 2 2 2 2 2 2 2 2 2 3 2 3 2|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
_____________________________________________________________________________________________________________________
| 6| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 8| 2| 4| 6| 3| 3| 3| 3| 3| 8| 3| 9| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 8| 3| 3|
| 7| 9| 7| 4| 6| 6| 6| 7| 5| 1| 6| 1| 6| 7| 7| 7| 7| 7| 7| 6| 6| 5| 9| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.1MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Artery, Inflammation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + M + + + M + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 1 1 |
Hyperplasia | 2 1 2 2 2 2 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 1 2 3 2 2 1 3 2 2 1 2 2 |
Hyperplasia, Lymphoid | 2 3|
Metaplasia, Osseous | |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + M M + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Inflammation, | |
Chronic | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 1 2 3 2 1 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Infiltration Cellular, | |
Mononuclear Cell | 1 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
Squamous Epithelium, Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X X X X X X X X X X X X X X X X X X X|
Hemorrhage | 1 1 |
Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 2 1 2 2 2 3 1 2 2 3 1 1 2|
Thrombosis | 1 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 2 |
Artery, Inflammation | 1 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
_____________________________________________________________________________________________________________________
| 6| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 8| 2| 4| 6| 3| 3| 3| 3| 3| 8| 3| 9| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 8| 3| 3|
| 7| 9| 7| 4| 6| 6| 6| 7| 5| 1| 6| 1| 6| 7| 7| 7| 7| 7| 7| 6| 6| 5| 9| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.1MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Artery, Mediastinum, Inflammation | 2 |
Serosa, Fibrosis | 2 1 2 2 2 2 2 2 2 2 2 1 2 2 2 2 1 1 2 3 1 2 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 1 1 |
Olfactory Epithelium, Atrophy | |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 1 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 2 1 1 1 1 1 2 2 1 1 1 1|
Respiratory Epithelium, Hyperplasia | |
__________________________________________________________________________|
Pleura | + + + |
Mesothelium, Hyperplasia | 2 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Degeneration | 4 |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Metaplasia, Osseous | 1 1 1 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 |
Artery, Inflammation | 1 |
Renal Tubule, Karyomegaly | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + A + + + + + + + + + + + + + + +|
Angiectasis | 1 1 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 3| 3| 1| 9| 3| 3| 7| 3| 3| 3| 3| 2| 8| 3| 5| 3| 3| 3| 3| 3| 9| 8| 7| 3| 3| |
| 5| 5| 7| 9| 6| 5| 2| 6| 5| 6| 7| 8| 7| 5| 8| 7| 6| 7| 6| 5| 9| 5| 2| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
0.1MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + M A + + + + + + + + + +| 48 |
Inflammation, Suppurative | 1 | 3 1.3|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 1 1.0|
Eosinophilic Focus | X X | 4 |
Hematopoietic Cell Proliferation | 2 | 4 2.3|
Inflammation | | 1 2.0|
Necrosis | 1 1 1 | 9 1.6|
Tension Lipidosis | | 2 |
Vacuolization Cytoplasmic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 8 |
Artery, Inflammation | 1 | 2 1.5|
Fat, Necrosis | 3 | 6 2.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 1 1 | 2 1.0|
Epithelium, Hyperplasia | 3 1 | 4 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 | 1 2.0|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + | 2 |
Inflammation | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 46 1.2|
Mineralization | 2 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 3| 3| 1| 9| 3| 3| 7| 3| 3| 3| 3| 2| 8| 3| 5| 3| 3| 3| 3| 3| 9| 8| 7| 3| 3| |
| 5| 5| 7| 9| 6| 5| 2| 6| 5| 6| 7| 8| 7| 5| 8| 7| 6| 7| 6| 5| 9| 5| 2| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
0.1MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Artery, Inflammation | 1 1 2 3 1 | 11 1.8|
Atrium, Thrombosis | | 1 2.0|
Valve, Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | | 1 3.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Hypertrophy | 1 2| 3 1.3|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 2 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + M M + M + M + M M + + + M + I + M M + + M| 29 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 48 |
Pars Distalis, Hyperplasia | 1 2 3 1 2 1 1 1 | 21 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 2 | 4 1.8|
Follicular Cell, Hyperplasia | 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + M + + + + + + + M M + + + + + + I + M| 41 |
__________________________________________________________________________|____________|
Ovary | M + + + + + + + + + + M + + + + + + + + M + + + +| 44 |
Cyst | 3 2 2 4 2 | 11 2.4|
Thrombosis | | 1 4.0|
Interstitial Cell, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Oviduct | + | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 4 2 | 3 2.7|
Hydrometra | 3 4 3 3 | 8 2.9|
Hyperplasia, Cystic | 2 2 3 3 3 1 3 2 1 2 1 2 1 2 3 2 2 3| 36 1.9|
Inflammation, Suppurative | | 1 4.0|
Thrombosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 3| 3| 1| 9| 3| 3| 7| 3| 3| 3| 3| 2| 8| 3| 5| 3| 3| 3| 3| 3| 9| 8| 7| 3| 3| |
| 5| 5| 7| 9| 6| 5| 2| 6| 5| 6| 7| 8| 7| 5| 8| 7| 6| 7| 6| 5| 9| 5| 2| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
0.1MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Fibrosis | 3 | 1 3.0|
Hyperplasia | 3 | 5 2.6|
__________________________________________________________________________|____________|
Lymph Node | + + | 6 |
Lumbar, Angiectasis | 4 | 1 4.0|
Lumbar, Hemorrhage | 4 | 1 4.0|
Lumbar, Inflammation, Chronic | 3 | 1 3.0|
Renal, Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + M + + +| 48 |
Foreign Body | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 33 1.0|
Hyperplasia | 2 2 3 2 2 2 2 2 2 2 2 3 2 2 3 | 31 2.2|
Artery, Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + + + + + M + + M + + + + + + + + + + M| 43 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 2 | 7 2.1|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + M + + + + M + + + + + M + + M + + + + +| 46 |
Foreign Body | 1 1 1 1| 7 1.0|
Hyperplasia | 3 3 3| 11 2.2|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 1 2 2 2 1 3 2 2 2 2 2 2 | 26 1.9|
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 2 | 11 2.1|
Metaplasia, Osseous | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + M M + + + + + + M + M M| 42 |
Hyperplasia, Lymphoid | 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 | 4 2.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Inflammation, | | |
Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1 2 1 1 2 1 4 | 14 1.6|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Meninges, Infiltration Cellular, | | |
Mononuclear Cell | 1 | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 3| 3| 1| 9| 3| 3| 7| 3| 3| 3| 3| 2| 8| 3| 5| 3| 3| 3| 3| 3| 9| 8| 7| 3| 3| |
| 5| 5| 7| 9| 6| 5| 2| 6| 5| 6| 7| 8| 7| 5| 8| 7| 6| 7| 6| 5| 9| 5| 2| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
0.1MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 1.0|
Squamous Epithelium, Hyperplasia | 1 1 1 2 2 1 1 | 10 1.2|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X X X X X X X X X X X X X X X| 35 |
Hemorrhage | 1 1 | 4 1.0|
Inflammation, Chronic Active | 2 1 1 2 2 2 1 1 1 2 2 2 1 2 1 1 2 1 2 2 2 1 2| 45 1.7|
Thrombosis | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 3 | 1 3.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 2 2.5|
Artery, Inflammation | | 1 1.0|
Artery, Mediastinum, Inflammation | | 1 2.0|
Serosa, Fibrosis | 2 1 3 2 2 2 2 2 2 2 1 1 2 2 1 2 2 2 2 2 2 2 1 2| 47 1.8|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 1 2 1 | 7 1.3|
Olfactory Epithelium, Atrophy | 1 1 1 | 3 1.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 1 1 2 2 1 | 10 1.2|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 2 1 1 2 1 1 2 2 1 1 1 1 | 27 1.3|
Respiratory Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pleura | | 3 |
Mesothelium, Hyperplasia | | 3 1.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Degeneration | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 3.0|
Metaplasia, Osseous | 1 | 4 1.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 43 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 3| 3| 1| 9| 3| 3| 7| 3| 3| 3| 3| 2| 8| 3| 5| 3| 3| 3| 3| 3| 9| 8| 7| 3| 3| |
| 5| 5| 7| 9| 6| 5| 2| 6| 5| 6| 7| 8| 7| 5| 8| 7| 6| 7| 6| 5| 9| 5| 2| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
0.1MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Artery, Inflammation | | 1 1.0|
Renal Tubule, Karyomegaly | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 1 | 3 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 6| 7| 4| 7| 6| 7| 5| 6| 7| 7| 5| 6| 4|
DAY ON TEST | 3| 3| 3| 3| 8| 0| 2| 3| 3| 1| 4| 3| 5| 3| 9| 3| 4| 3| 7| 5| 3| 3| 1| 9| 8|
| 7| 7| 6| 5| 7| 0| 9| 7| 5| 0| 5| 5| 8| 7| 3| 6| 2| 7| 8| 0| 7| 6| 2| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.3MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + A + + + + + + M + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + A + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + A + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + + +|
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | |
Clear Cell Focus | |
Eosinophilic Focus | X X X X X X X |
Eosinophilic Focus, Multiple | |
Hematopoietic Cell Proliferation | 3 |
Necrosis | 2 1 |
Tension Lipidosis | X |
Bile Duct, Degeneration, Hyaline | |
__________________________________________________________________________|
Mesentery | + + + |
Artery, Inflammation | 1 |
Fat, Necrosis | 1 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Inflammation, Chronic | 2 |
Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + A + + + + + + + + + +|
Inflammation, Suppurative | 2 |
Necrosis, Focal | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1|
Necrosis | |
Artery, Inflammation | 1 2 1 2 1 3 |
Atrium, Thrombosis | |
Epicardium, Inflammation | 2 1 1 |
Pericardium, Inflammation | 3 2 2 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 6| 7| 4| 7| 6| 7| 5| 6| 7| 7| 5| 6| 4|
DAY ON TEST | 3| 3| 3| 3| 8| 0| 2| 3| 3| 1| 4| 3| 5| 3| 9| 3| 4| 3| 7| 5| 3| 3| 1| 9| 8|
| 7| 7| 6| 5| 7| 0| 9| 7| 5| 0| 5| 5| 8| 7| 3| 6| 2| 7| 8| 0| 7| 6| 2| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.3MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Amyloid Deposition | |
Degeneration, Focal | 2 |
Hyperplasia | 2 |
Hypertrophy | 1 1 1 1 1 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | M + + + + M + M + + + + + + M M M + M M + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Pars Distalis, Hyperplasia | 2 1 4 1 2 4 1 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + M + + + + + M + I + + + + M + + M M +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + I + + + + + + + + + +|
Angiectasis | 2 |
Cyst | 2 1 2 1 |
Thrombosis | |
Interstitial Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 3 2 |
Hydrometra | 4 2 2 2|
Hyperplasia, Cystic | 1 2 2 2 1 2 2 2 3 2 2 2 3 1 2 2 |
Inflammation, Suppurative | 1 |
Thrombosis | 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + |
Iliac, Hematopoietic Cell | |
Proliferation | |
Iliac, Hyperplasia | 3 |
Lumbar, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 2 2 2 3 2 2 2 3 2 2 2 2 4 2|
Artery, Inflammation | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 6| 7| 4| 7| 6| 7| 5| 6| 7| 7| 5| 6| 4|
DAY ON TEST | 3| 3| 3| 3| 8| 0| 2| 3| 3| 1| 4| 3| 5| 3| 9| 3| 4| 3| 7| 5| 3| 3| 1| 9| 8|
| 7| 7| 6| 5| 7| 0| 9| 7| 5| 0| 5| 5| 8| 7| 3| 6| 2| 7| 8| 0| 7| 6| 2| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.3MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + M M + + + + + + + M + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + + + + + I + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 2 4 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 1 1 1 1 1 1 1 1|
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 3 2 4 2 2 4 3 2 4 2 2 3 2 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + A + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 3 2 2 1 2 2 4 2 2 1 |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 3 2 |
__________________________________________________________________________|
Thymus | + + + + M + M + + + + + + + + + M + M + M + + + +|
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
Inflammation, Suppurative | 3 |
Hair Follicle, Atrophy | 3 |
Subcutaneous Tissue, Hemorrhage | |
Subcutaneous Tissue, Inflammation, | |
Chronic | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 2 1 1 2 2 2 |
Maxilla, Fracture | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Infiltration Cellular, | |
Mononuclear Cell | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Squamous Epithelium, Hyperplasia | 2 1 1 2 1 2 1|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X X X X X X X X X X X X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 6| 7| 4| 7| 6| 7| 5| 6| 7| 7| 5| 6| 4|
DAY ON TEST | 3| 3| 3| 3| 8| 0| 2| 3| 3| 1| 4| 3| 5| 3| 9| 3| 4| 3| 7| 5| 3| 3| 1| 9| 8|
| 7| 7| 6| 5| 7| 0| 9| 7| 5| 0| 5| 5| 8| 7| 3| 6| 2| 7| 8| 0| 7| 6| 2| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.3MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | |
Hemorrhage | 1 4 |
Inflammation, Chronic Active | 3 2 2 2 2 2 2 2 2 3 1 2 2 2 3 2 2 2 2 2 3 2 2 2 3|
Thrombosis | 2 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
Alveolus, Proteinosis | 1 1 2 1 |
Bronchiole, Bronchus, Degeneration, | |
Hyaline | |
Interstitium, Fibrosis | 2 |
Serosa, Fibrosis | 2 2 4 1 3 3 2 3 4 1 4 2 2 3 4 3 2 2 3 2 4 3 3 4 3|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 |
Olfactory Epithelium, Atrophy | |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 1 1 1 |
__________________________________________________________________________|
Pleura | + + + + + + + + + |
Mesothelium, Hyperplasia | 2 2 4 1 1 1 2 1 4 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Hyaline | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Osseous | 1 |
Nephropathy | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 |
Artery, Inflammation | 2 |
Glomerulus, Inflammation, Chronic | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + A + + + + + + + M + +|
Angiectasis | 1 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 6| 7| 7| 7| 4| 7| 1| 7| 7| 6| 7| 5| 6| 6| 5| 6| 6| 7| 7| 4| 7| |
DAY ON TEST | 2| 3| 2| 3| 0| 3| 3| 0| 9| 3| 9| 3| 3| 1| 3| 3| 9| 3| 9| 6| 1| 2| 3| 2| 0| |
| 1| 6| 7| 5| 8| 6| 5| 5| 6| 6| 7| 6| 6| 5| 5| 3| 5| 3| 4| 9| 9| 6| 7| 1| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
0.3MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | M + + + + + + + + + A + + + + + + + + + + A + + A| 43 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + M + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + A + A + + + + + + + + + + A + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A + A + + + + + + + A + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + + +| 48 |
Peyer's Patch, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 4 | 2 2.5|
Basophilic Focus | X X | 2 |
Clear Cell Focus | X X | 2 |
Eosinophilic Focus | X X X | 10 |
Eosinophilic Focus, Multiple | X X | 2 |
Hematopoietic Cell Proliferation | 2 3 | 3 2.7|
Necrosis | 3 | 3 2.0|
Tension Lipidosis | | 1 |
Bile Duct, Degeneration, Hyaline | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Artery, Inflammation | | 1 1.0|
Fat, Necrosis | 2 | 3 1.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 2 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 |
Inflammation, Chronic | | 1 2.0|
Epithelium, Hyperplasia | 2 2 | 3 1.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | | 1 2.0|
Necrosis, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 2 1 2 1 1 1 2 1| 38 1.1|
Necrosis | 1 | 1 1.0|
Artery, Inflammation | 1 2 2 2 2 2 2 | 13 1.8|
Atrium, Thrombosis | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 6| 7| 7| 7| 4| 7| 1| 7| 7| 6| 7| 5| 6| 6| 5| 6| 6| 7| 7| 4| 7| |
DAY ON TEST | 2| 3| 2| 3| 0| 3| 3| 0| 9| 3| 9| 3| 3| 1| 3| 3| 9| 3| 9| 6| 1| 2| 3| 2| 0| |
| 1| 6| 7| 5| 8| 6| 5| 5| 6| 6| 7| 6| 6| 5| 5| 3| 5| 3| 4| 9| 9| 6| 7| 1| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
0.3MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Epicardium, Inflammation | 2 2 2 1 | 7 1.6|
Pericardium, Inflammation | | 4 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | 2 1 | 2 1.5|
Degeneration, Focal | | 1 2.0|
Hyperplasia | | 1 2.0|
Hypertrophy | 1 1 1 1 | 10 1.1|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 2 | 3 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + M + M + M M M + + + + + + + + M + M M M +| 30 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Hyperplasia | 2 1 1 2 1 1 2 | 15 1.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M + + + M + + + + + + + + + + + + + + M + + + M +| 40 |
__________________________________________________________________________|____________|
Ovary | + M + + + + + + + + + + + I + + + + + + + + + + +| 47 |
Angiectasis | | 1 2.0|
Cyst | 2 4 3 3 4 | 9 2.4|
Thrombosis | 3 4 | 2 3.5|
Interstitial Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 5 2.2|
Hydrometra | 2 | 5 2.4|
Hyperplasia, Cystic | 2 2 3 2 2 3 1 3 2 1 2 2 2 2 3 2 | 32 2.0|
Inflammation, Suppurative | | 1 1.0|
Thrombosis | | 2 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 | 7 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 6| 7| 7| 7| 4| 7| 1| 7| 7| 6| 7| 5| 6| 6| 5| 6| 6| 7| 7| 4| 7| |
DAY ON TEST | 2| 3| 2| 3| 0| 3| 3| 0| 9| 3| 9| 3| 3| 1| 3| 3| 9| 3| 9| 6| 1| 2| 3| 2| 0| |
| 1| 6| 7| 5| 8| 6| 5| 5| 6| 6| 7| 6| 6| 5| 5| 3| 5| 3| 4| 9| 9| 6| 7| 1| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
0.3MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + | 8 |
Iliac, Hematopoietic Cell | | |
Proliferation | 2 | 1 2.0|
Iliac, Hyperplasia | | 1 3.0|
Lumbar, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 40 1.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia | 2 4 2 2 2 2 2 2 1 2 2 2 2 | 28 2.2|
Artery, Inflammation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + M M + + + M + + + + M + +| 42 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hematopoietic Cell Proliferation | 4 | 1 4.0|
Hyperplasia | 2 2 2 | 7 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | 1 1 1 1 1 1 1 | 16 1.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia | 3 2 3 2 3 2 4 2 2 2 2 2 3 3| 29 2.6|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 2 3 2 2 3 2 2 3 2 | 21 2.1|
Hyperplasia, Lymphoid | 2 2 4 4 | 14 2.4|
__________________________________________________________________________|____________|
Thymus | + + + + M + + M + + + + + + + + M + + + + + + + +| 42 |
Hyperplasia, Lymphoid | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1| 3 1.7|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 4.0|
Inflammation, Suppurative | | 1 3.0|
Hair Follicle, Atrophy | | 1 3.0|
Subcutaneous Tissue, Hemorrhage | 4 | 1 4.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 6| 7| 7| 7| 4| 7| 1| 7| 7| 6| 7| 5| 6| 6| 5| 6| 6| 7| 7| 4| 7| |
DAY ON TEST | 2| 3| 2| 3| 0| 3| 3| 0| 9| 3| 9| 3| 3| 1| 3| 3| 9| 3| 9| 6| 1| 2| 3| 2| 0| |
| 1| 6| 7| 5| 8| 6| 5| 5| 6| 6| 7| 6| 6| 5| 5| 3| 5| 3| 4| 9| 9| 6| 7| 1| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
0.3MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Fibrous Osteodystrophy | 1 1 2 1 1 1 1 1 1| 16 1.3|
Maxilla, Fracture | X | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Meninges, Infiltration Cellular, | | |
Mononuclear Cell | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 1| 2 1.0|
Squamous Epithelium, Hyperplasia | 2 1 2 1 2 1 1 1 | 15 1.4|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X X X X X X X X X X X X X X X X X X X X X X X X| 49 |
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Hemorrhage | 2 1 | 4 2.0|
Inflammation, Chronic Active | 2 2 2 2 2 2 1 2 3 1 3 1 3 2 2 2 2 2 2 2 2 2 2 3 2| 50 2.1|
Thrombosis | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 2 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 3 2 | 3 2.3|
Alveolus, Proteinosis | 1 2 1 2 | 8 1.4|
Bronchiole, Bronchus, Degeneration, | | |
Hyaline | 3 2 | 2 2.5|
Interstitium, Fibrosis | 1 | 2 1.5|
Serosa, Fibrosis | 2 3 2 2 3 1 1 4 4 1 2 1 4 2 1 2 3 2 2 2 3 3 2 3| 49 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 2 1.0|
Olfactory Epithelium, Atrophy | 1 1 | 2 1.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 | 2 1.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 2 1 1 3 1 1 1 | 14 1.2|
__________________________________________________________________________|____________|
Pleura | + + + +| 13 |
Mesothelium, Hyperplasia | 1 3 1 2| 13 1.9|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Hyaline | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 6| 7| 7| 7| 4| 7| 1| 7| 7| 6| 7| 5| 6| 6| 5| 6| 6| 7| 7| 4| 7| |
DAY ON TEST | 2| 3| 2| 3| 0| 3| 3| 0| 9| 3| 9| 3| 3| 1| 3| 3| 9| 3| 9| 6| 1| 2| 3| 2| 0| |
| 1| 6| 7| 5| 8| 6| 5| 5| 6| 6| 7| 6| 6| 5| 5| 3| 5| 3| 4| 9| 9| 6| 7| 1| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
0.3MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Metaplasia, Osseous | 1 | 2 1.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3 1 1 1 1| 36 1.1|
Artery, Inflammation | 2 2 | 3 2.0|
Glomerulus, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | 2 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 2| 3| 3| 1| 3| 3| 3| 5| 3| 3| 6| 3| 3| 3|
| 6| 3| 3| 5| 3| 3| 4| 3| 1| 4| 4| 6| 4| 4| 6| 5| 4| 4| 9| 4| 4| 4| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + + + + + + + + + + + + + A + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + A + + + + + A + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + A + + + + + + + + + A + + +|
Peyer's Patch, Hyperplasia | 2 4 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X |
Clear Cell Focus | |
Clear Cell Focus, Multiple | X |
Eosinophilic Focus | X X X X|
Eosinophilic Focus, Multiple | X |
Hematopoietic Cell Proliferation | |
Inflammation, Focal, Granulomatous | |
Necrosis | |
Tension Lipidosis | X X |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 3 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 |
Duct, Cyst | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
Ulcer | 1 |
Epithelium, Hyperplasia | 3 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Necrosis, Focal | |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1|
Artery, Inflammation | 1 1 1 |
Artery, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 2| 3| 3| 1| 3| 3| 3| 5| 3| 3| 6| 3| 3| 3|
| 6| 3| 3| 5| 3| 3| 4| 3| 1| 4| 4| 6| 4| 4| 6| 5| 4| 4| 9| 4| 4| 4| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 |
Hypertrophy | 1 2 1 1 2 1 2 2 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 3 1 1 1|
__________________________________________________________________________|
Parathyroid Gland | M + + M + M + + + + + M M + M + M + M + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + M + + + + + + + M + + M + + + + + + + + + +|
Follicle, Degeneration, Cystic | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 2 |
Inflammation | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 2 2 3 2 2 3 3 1 3 |
Hyperplasia, Squamous | 2 |
Inflammation | 2 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2|
Atrophy | 1 2 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + M + M + + M + + M + M + + M + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M M + + + + + M + + + M + + + M + M M + M + M +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + + + + + + + + M + + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia | 2 2 2 3 2|
Inflammation, Granulomatous | |
Artery, Inflammation | 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 2| 3| 3| 1| 3| 3| 3| 5| 3| 3| 6| 3| 3| 3|
| 6| 3| 3| 5| 3| 3| 4| 3| 1| 4| 4| 6| 4| 4| 6| 5| 4| 4| 9| 4| 4| 4| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + + + + + M M + + M + M + + M + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hematopoietic Cell Proliferation | 2 1 2 1 2 2 |
__________________________________________________________________________|
Thymus | M M + M + + + M I + + M + M M + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Prepuce, Inflammation, Chronic Active| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 |
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 |
Epiglottis, Metaplasia, Squamous | |
Squamous Epithelium, Hyperplasia | 1 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 3 |
Inflammation, Chronic Active | 1 1|
Inflammation, Suppurative | 1 |
Thrombosis | 1 |
Alveolar Epithelium, Hyperplasia | |
Bronchiole, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 |
Olfactory Epithelium, Atrophy | 1 |
Olfactory Epithelium, Degeneration, | |
Hyaline | |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + A + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 2| 3| 3| 1| 3| 3| 3| 5| 3| 3| 6| 3| 3| 3|
| 6| 3| 3| 5| 3| 3| 4| 3| 1| 4| 4| 6| 4| 4| 6| 5| 4| 4| 9| 4| 4| 4| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Metaplasia, Osseous | 1 1 1 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 3 4 1 1 1 1 1 1 2 1|
Glomerulus, Inflammation, Chronic | |
Renal Tubule, Hyperplasia | 2 1|
__________________________________________________________________________|
Ureter | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| |
DAY ON TEST | 3| 3| 3| 9| 6| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 6| 3| 3| 3| 0| 3| 3| 6| |
| 5| 3| 5| 0| 2| 4| 3| 3| 5| 3| 3| 6| 3| 4| 3| 3| 4| 9| 3| 5| 5| 7| 3| 4| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + M + + + + + + A + + + + + M + + + + + + A| 43 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + + + + + A| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + M + + + + + + A + + + + + A + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + A| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + + + A| 45 |
Peyer's Patch, Hyperplasia | 1 2 | 5 2.2|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 1.0|
Basophilic Focus | | 2 |
Clear Cell Focus | X | 1 |
Clear Cell Focus, Multiple | | 1 |
Eosinophilic Focus | X X X X X | 9 |
Eosinophilic Focus, Multiple | | 1 |
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Inflammation, Focal, Granulomatous | 1 | 1 1.0|
Necrosis | 4 2 2 2 | 4 2.5|
Tension Lipidosis | | 2 |
Vacuolization Cytoplasmic | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Fat, Necrosis | 2 | 4 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 | 3 1.0|
Duct, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | | 1 1.0|
Ulcer | | 1 1.0|
Epithelium, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 2 | 1 2.0|
Necrosis, Focal | 1 | 1 1.0|
Epithelium, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
Mineralization | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| |
DAY ON TEST | 3| 3| 3| 9| 6| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 6| 3| 3| 3| 0| 3| 3| 6| |
| 5| 3| 5| 0| 2| 4| 3| 3| 5| 3| 3| 6| 3| 4| 3| 3| 4| 9| 3| 5| 5| 7| 3| 4| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 4 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 39 1.1|
Artery, Inflammation | | 3 1.0|
Artery, Mineralization | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hyperplasia | | 1 2.0|
Hypertrophy | 2 2 2 1 1 1 1 1 2 2 2 1 1 1 | 30 1.3|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 3 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 1 1 | 8 1.6|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + M + + + M + + M M + + + M + + + + M M + + +| 33 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Follicle, Degeneration, Cystic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | 4 | 2 3.0|
Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 2 2 2 2 2 2 2 3 3 2 3 3 2 | 25 2.3|
Hyperplasia, Squamous | | 1 2.0|
Inflammation | 3 3 2 | 5 2.8|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Atrophy | 2 2 | 6 1.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 | 5 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| |
DAY ON TEST | 3| 3| 3| 9| 6| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 6| 3| 3| 3| 0| 3| 3| 6| |
| 5| 3| 5| 0| 2| 4| 3| 3| 5| 3| 3| 6| 3| 4| 3| 3| 4| 9| 3| 5| 5| 7| 3| 4| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M M + + M + + + + + M + M + M + + + M + M +| 35 |
Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M M M M + M M + M + + + M M M + M + + M M| 28 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | | 1 2.0|
Hyperplasia | 2 2 2 3 2 3 | 11 2.3|
Inflammation, Granulomatous | 3 2 | 2 2.5|
Artery, Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + + M + + + M + + + + + + + + + + + + + M + +| 40 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 2 2.5|
Hematopoietic Cell Proliferation | 1 1 1 2 4 1 1 2 | 14 1.6|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + M + M + + M + M M + + + M +| 35 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 2 2.0|
Prepuce, Inflammation, Chronic Active| 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrous Osteodystrophy | 1 | 2 1.0|
Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 1 1 | 5 1.0|
Epiglottis, Metaplasia, Squamous | 1 | 1 1.0|
Squamous Epithelium, Hyperplasia | 1 1 1 2 | 6 1.3|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 1 | 5 1.4|
Inflammation, Chronic Active | | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| |
DAY ON TEST | 3| 3| 3| 9| 6| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 6| 3| 3| 3| 0| 3| 3| 6| |
| 5| 3| 5| 0| 2| 4| 3| 3| 5| 3| 3| 6| 3| 4| 3| 3| 4| 9| 3| 5| 5| 7| 3| 4| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Suppurative | | 1 1.0|
Thrombosis | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2 1 | 2 1.5|
Bronchiole, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 1 | 3 1.0|
Olfactory Epithelium, Atrophy | 1 | 2 1.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1| 1 1.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 1| 5 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + I + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 2 2.0|
Metaplasia, Osseous | 1 1 | 5 1.0|
Nephropathy | 1 1 1 1 4 2 1 2 2 1 1 1 1 1 1 1 1 1 1 2 2 1 1 1 1| 47 1.3|
Glomerulus, Inflammation, Chronic | 2 | 1 2.0|
Renal Tubule, Hyperplasia | 1 1 1 | 5 1.2|
__________________________________________________________________________|____________|
Ureter | + | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
_____________________________________________________________________________________________________________________
| 7| 7| 5| 5| 7| 7| 7| 7| 6| 7| 5| 4| 5| 6| 7| 7| 7| 7| 3| 5| 7| 4| 7| 5| 7|
DAY ON TEST | 3| 3| 8| 3| 2| 0| 3| 3| 3| 3| 7| 2| 7| 8| 3| 3| 3| 3| 3| 5| 3| 5| 3| 6| 3|
| 5| 5| 9| 0| 9| 0| 3| 3| 8| 4| 4| 1| 1| 2| 5| 3| 0| 5| 1| 7| 4| 7| 3| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.03 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + A + + + A + + + + + + + + + + + +|
Degeneration, Hyaline | |
Inflammation, Suppurative | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + A + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + A + + +|
Amyloid Deposition | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
Basophilic Focus | X |
Clear Cell Focus | |
Eosinophilic Focus | X X X X X X |
Eosinophilic Focus, Multiple | |
Necrosis | 4 2 3 |
Tension Lipidosis | |
__________________________________________________________________________|
Mesentery | + + |
Artery, Inflammation | 4 4 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mast Cell | 2 |
Ulcer | |
Artery, Inflammation | |
Epithelium, Hyperplasia | 1 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
Inflammation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Aneurysm | |
Aorta, Hemorrhage | |
Aorta, Inflammation | |
Aorta, Mineralization | 2 |
Aorta, Necrosis | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 2|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
_____________________________________________________________________________________________________________________
| 7| 7| 5| 5| 7| 7| 7| 7| 6| 7| 5| 4| 5| 6| 7| 7| 7| 7| 3| 5| 7| 4| 7| 5| 7|
DAY ON TEST | 3| 3| 8| 3| 2| 0| 3| 3| 3| 3| 7| 2| 7| 8| 3| 3| 3| 3| 3| 5| 3| 5| 3| 6| 3|
| 5| 5| 9| 0| 9| 0| 3| 3| 8| 4| 4| 1| 1| 2| 5| 3| 0| 5| 1| 7| 4| 7| 3| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.03 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Hemorrhage | 2 |
Artery, Inflammation | 2 1 1 2 1 1|
Atrium, Inflammation, Chronic | 1 |
Atrium, Thrombosis | 2 |
Epicardium, Inflammation | 2 |
Pericardium, Inflammation | 2 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
Angiectasis | |
Degeneration, Focal | |
Hyperplasia | |
Hypertrophy | 1 1 1 1 1 1 1|
Necrosis | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + M + M M + + M I + M + + + M + + + + + + M M M|
Amyloid Deposition | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Amyloid Deposition | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 2 3 2 3 2 3|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
_____________________________________________________________________________________________________________________
| 7| 7| 5| 5| 7| 7| 7| 7| 6| 7| 5| 4| 5| 6| 7| 7| 7| 7| 3| 5| 7| 4| 7| 5| 7|
DAY ON TEST | 3| 3| 8| 3| 2| 0| 3| 3| 3| 3| 7| 2| 7| 8| 3| 3| 3| 3| 3| 5| 3| 5| 3| 6| 3|
| 5| 5| 9| 0| 9| 0| 3| 3| 8| 4| 4| 1| 1| 2| 5| 3| 0| 5| 1| 7| 4| 7| 3| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.03 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia | 2 3 2 2 2 4 4 2 3 2 1 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | M M M + + + + + M + + M + M + + M + + M + + + M M|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + + + + + + + + M|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 1 1 1 1 1 1 1 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia | 3 2 2 2 4 4 2 3 2 2 2 2 2 4 2 1 2 |
Artery, Inflammation | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 |
Angiectasis | |
Hematopoietic Cell Proliferation | 2 3 3 4 2 3 2 1 2 2 2 2 2 1 2 2 3 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + M + + + M M + M + + M + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M + M M M M M M M M M M + M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Suppurative | |
Prepuce, Inflammation, Chronic Active| 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + |
Maxilla, Fracture | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + A + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
Squamous Epithelium, Hyperplasia | 1 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X X X X X X X X X X X X X X X X X X X X X X 1 X|
Hemorrhage | |
Inflammation, Chronic Active | 2 3 3 2 2 3 3 3 3 2 2 3 3 2 3 2 4 3 4 3 3 2 3 4 2|
Alveolar Epithelium, Hyperplasia | 2 2|
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Alveolus, Proteinosis | 1 1 1 1 1 1|
Artery, Mediastinum, Inflammation | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
_____________________________________________________________________________________________________________________
| 7| 7| 5| 5| 7| 7| 7| 7| 6| 7| 5| 4| 5| 6| 7| 7| 7| 7| 3| 5| 7| 4| 7| 5| 7|
DAY ON TEST | 3| 3| 8| 3| 2| 0| 3| 3| 3| 3| 7| 2| 7| 8| 3| 3| 3| 3| 3| 5| 3| 5| 3| 6| 3|
| 5| 5| 9| 0| 9| 0| 3| 3| 8| 4| 4| 1| 1| 2| 5| 3| 0| 5| 1| 7| 4| 7| 3| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.03 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Interstitium, Fibrosis | |
Serosa, Fibrosis | 3 3 4 4 3 4 4 4 4 4 3 2 4 4 4 3 4 4 3 2 3 4 4 2 4|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Hemorrhage | |
Inflammation, Suppurative | 1 1 1 |
Olfactory Epithelium, Atrophy | 2 1 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 |
__________________________________________________________________________|
Pleura | + + + + + + + |
Mesothelium, Hyperplasia | 4 4 1 2 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + A + + + + + + + + + + + + + + I +|
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Degeneration | 4 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 |
Cyst | |
Infiltration Cellular, Focal, Mixed | |
Cell | |
Nephropathy | 1 1 1 1 2 1 1 1 1 3 1 1 3 1 4 2 2 |
Artery, Inflammation | 3 1 |
Glomerulus, Inflammation, Chronic | 3 |
Renal Tubule, Hyperplasia | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Necrosis | 1 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 5| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 4| |
DAY ON TEST | 3| 6| 1| 0| 3| 3| 3| 3| 0| 0| 3| 8| 0| 0| 3| 3| 3| 3| 8| 8| 3| 6| 3| 3| 0| |
| 5| 2| 5| 0| 3| 4| 3| 4| 4| 5| 4| 7| 6| 0| 3| 4| 4| 5| 7| 7| 5| 2| 4| 3| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.03 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | M + A + + + + + + + + + M + + + + + + + M + + + A| 43 |
Degeneration, Hyaline | 1 | 1 1.0|
Inflammation, Suppurative | 1 | 1 1.0|
Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + A| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A I + + + + A A + + + + M + + + + + + + + + A| 43 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + A A + + + + + + + + + + + + + + A| 44 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + A| 47 |
Amyloid Deposition | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | 4 | 2 3.0|
Basophilic Focus | | 1 |
Clear Cell Focus | X | 1 |
Eosinophilic Focus | X X X X X X X X X | 15 |
Eosinophilic Focus, Multiple | X | 1 |
Necrosis | 2 | 4 2.8|
Tension Lipidosis | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + | 5 |
Artery, Inflammation | 4 2 | 4 3.5|
Fat, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mast Cell | | 1 2.0|
Ulcer | 2 1 | 2 1.5|
Artery, Inflammation | 2 | 1 2.0|
Epithelium, Hyperplasia | 1 2 3 2 | 6 1.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Tooth | + + | 2 |
Inflammation | 2 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 2 |
Aorta, Aneurysm | 4 | 1 4.0|
Aorta, Hemorrhage | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 5| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 4| |
DAY ON TEST | 3| 6| 1| 0| 3| 3| 3| 3| 0| 0| 3| 8| 0| 0| 3| 3| 3| 3| 8| 8| 3| 6| 3| 3| 0| |
| 5| 2| 5| 0| 3| 4| 3| 4| 4| 5| 4| 7| 6| 0| 3| 4| 4| 5| 7| 7| 5| 2| 4| 3| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.03 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Aorta, Inflammation | 4 | 1 4.0|
Aorta, Mineralization | | 1 2.0|
Aorta, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1| 41 1.1|
Hemorrhage | | 1 2.0|
Artery, Inflammation | 3 1 2 1 3 2 2 4 2 2 1 2| 18 1.8|
Atrium, Inflammation, Chronic | | 1 1.0|
Atrium, Thrombosis | | 1 2.0|
Epicardium, Inflammation | 3 | 2 2.5|
Pericardium, Inflammation | 2 2 3 1 | 6 2.2|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | 3 | 2 2.5|
Angiectasis | 2 | 1 2.0|
Degeneration, Focal | 1 | 1 1.0|
Hyperplasia | 2 | 1 2.0|
Hypertrophy | 1 1 2 1 2 1 1 1 | 15 1.1|
Necrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + M M + + M M + + M M M + + M + + + + + + + M| 30 |
Amyloid Deposition | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + + M| 47 |
Pars Distalis, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 48 |
Amyloid Deposition | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 2 2 2 4 2 2 4 2 2 2 3 2 | 21 2.4|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + I + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 5| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 4| |
DAY ON TEST | 3| 6| 1| 0| 3| 3| 3| 3| 0| 0| 3| 8| 0| 0| 3| 3| 3| 3| 8| 8| 3| 6| 3| 3| 0| |
| 5| 2| 5| 0| 3| 4| 3| 4| 4| 5| 4| 7| 6| 0| 3| 4| 4| 5| 7| 7| 5| 2| 4| 3| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.03 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + A + + + + + + + + + + + + + + A| 47 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 2 2 1| 9 1.7|
__________________________________________________________________________|____________|
Lymph Node | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + M + + + + + M + + + + + +| 48 |
Foreign Body | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 43 1.0|
Hyperplasia | 2 1 2 2 2 2 3 2 4 2 2 4 2 2 2 2 2 2| 36 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M M + + + + + + + + + + + + + M + M M M M + M +| 32 |
Hyperplasia | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + M + + + +| 47 |
Hyperplasia | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
Foreign Body | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 24 1.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia | 2 3 2 3 3 2 4 2 2 3 3 2 2 2 3 3 2| 34 2.5|
Artery, Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | 3 | 2 3.0|
Angiectasis | 1 2 | 2 1.5|
Hematopoietic Cell Proliferation | 2 2 2 1 2 2 2 1 2 2 1 3 1 2 2 2 2| 34 2.0|
Hyperplasia, Lymphoid | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Thymus | + + M M + + + + + + + + M + + + + M + M + + + + M| 39 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 1 3.0|
Inflammation, Suppurative | 2 | 1 2.0|
Prepuce, Inflammation, Chronic Active| 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Maxilla, Fracture | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 5| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 4| |
DAY ON TEST | 3| 6| 1| 0| 3| 3| 3| 3| 0| 0| 3| 8| 0| 0| 3| 3| 3| 3| 8| 8| 3| 6| 3| 3| 0| |
| 5| 2| 5| 0| 3| 4| 3| 4| 4| 5| 4| 7| 6| 0| 3| 4| 4| 5| 7| 7| 5| 2| 4| 3| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.03 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 1 1 | 3 1.0|
Squamous Epithelium, Hyperplasia | 1 | 3 1.3|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X X X X X X X X X X X X X X X X X X X X X X X X | 49 1.0|
Hemorrhage | 4 | 1 4.0|
Inflammation, Chronic Active | 3 4 3 2 3 3 3 4 2 2 3 3 3 3 2 4 2 3 4 3 4 2 2 3 4| 50 2.9|
Alveolar Epithelium, Hyperplasia | 4 3 1 | 5 2.4|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 3 | 1 3.0|
Alveolus, Proteinosis | 1 1 1 1 1 1 1 1 | 14 1.0|
Artery, Mediastinum, Inflammation | 4 4 | 2 4.0|
Interstitium, Fibrosis | 2 2 | 2 2.0|
Serosa, Fibrosis | 3 4 4 4 4 3 3 2 3 3 3 4 4 4 4 4 3 3 4 4 3 3 4 4 3| 50 3.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X | 1 |
Hemorrhage | 4 | 1 4.0|
Inflammation, Suppurative | 2 1 | 5 1.2|
Olfactory Epithelium, Atrophy | 1 1 | 4 1.3|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 | 2 1.0|
__________________________________________________________________________|____________|
Pleura | + + + + + + + + + + + + | 19 |
Mesothelium, Hyperplasia | 1 2 2 4 1 2 3 1 3 1 4 1 | 19 2.1|
__________________________________________________________________________|____________|
Trachea | + + + I + + + + + + + + + + + + + + I + + + + + +| 46 |
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Degeneration | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | 3 | 2 3.0|
Cyst | 2 | 1 2.0|
Infiltration Cellular, Focal, Mixed | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 5| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 4| |
DAY ON TEST | 3| 6| 1| 0| 3| 3| 3| 3| 0| 0| 3| 8| 0| 0| 3| 3| 3| 3| 8| 8| 3| 6| 3| 3| 0| |
| 5| 2| 5| 0| 3| 4| 3| 4| 4| 5| 4| 7| 6| 0| 3| 4| 4| 5| 7| 7| 5| 2| 4| 3| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.03 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Cell | 1 | 1 1.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 4 3 1 1 1| 40 1.4|
Artery, Inflammation | 2 2 1 | 5 1.8|
Glomerulus, Inflammation, Chronic | | 1 3.0|
Renal Tubule, Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Necrosis | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| 6| 6| 5| 7| 7|
DAY ON TEST | 3| 2| 7| 3| 4| 9| 3| 3| 3| 5| 7| 3| 3| 5| 3| 8| 3| 3| 3| 7| 8| 8| 6| 3| 3|
| 3| 8| 8| 3| 4| 7| 4| 4| 4| 7| 8| 3| 4| 0| 5| 2| 3| 5| 3| 2| 1| 1| 2| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.1MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M + + + A + + + + + + + + + + + + + M A + + + +|
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + A A + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A M + + A + + + + + + + + + A A + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + A A + + + +|
Inflammation, Acute | 1 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + A + + + + + + + + + A A + + + +|
Artery, Inflammation | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus, Multiple | X |
Eosinophilic Focus | X X X |
Eosinophilic Focus, Multiple | X X X|
Inflammation, Chronic Active | 2 |
Inflammation, Focal, Granulomatous | 2 |
Mixed Cell Focus | |
Necrosis | 4 1 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Mesentery | + + + |
Artery, Inflammation | |
Fat, Necrosis | 3 4 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + A + + + + +|
Atrophy | 2 |
Artery, Inflammation | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + A + + + + +|
Infiltration Cellular | |
Inflammation, Chronic | |
Ulcer | 1 |
Epithelium, Hyperplasia | 2 1 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + A + + + + +|
Infiltration Cellular | |
Inflammation, Suppurative | 1 |
Necrosis, Focal | 1 |
Epithelium, Hyperplasia | 4 |
__________________________________________________________________________|
Tooth | + |
Inflammation | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| 6| 6| 5| 7| 7|
DAY ON TEST | 3| 2| 7| 3| 4| 9| 3| 3| 3| 5| 7| 3| 3| 5| 3| 8| 3| 3| 3| 7| 8| 8| 6| 3| 3|
| 3| 8| 8| 3| 4| 7| 4| 4| 4| 7| 8| 3| 4| 0| 5| 2| 3| 5| 3| 2| 1| 1| 2| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.1MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Inflammation | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 2 1 2 1 1 1 1 1 1 2 1 1 4 1 2 1 1|
Mineralization | 1 |
Artery, Inflammation | 3 1 2 2 1 1 3 |
Epicardium, Inflammation | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + A + + + + +|
Hyperplasia | 2 2 |
Hypertrophy | 1 1 2 1 1 1 2 1 1 3|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + A + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + A + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | M + + + M + + M + M M M + + + + + + + A + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + M + + M + + + A + + + + +|
Pars Distalis, Hyperplasia | 1 |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + A + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 4 2 2 2 2 2 3 4 3|
Inflammation | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + M +|
Foreign Body | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Hyperplasia | 2 2 2 1 2 1 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| 6| 6| 5| 7| 7|
DAY ON TEST | 3| 2| 7| 3| 4| 9| 3| 3| 3| 5| 7| 3| 3| 5| 3| 8| 3| 3| 3| 7| 8| 8| 6| 3| 3|
| 3| 8| 8| 3| 4| 7| 4| 4| 4| 7| 8| 3| 4| 0| 5| 2| 3| 5| 3| 2| 1| 1| 2| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.1MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + M + + + M M + + + + M + + + M + M M + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + A + + + + +|
Hemorrhage | |
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + + + + + + + + + + I + + + + + + + + + + +|
Foreign Body | 1 1 1 1 1 |
Hyperplasia | 2 1 2 3 2 3 2 2 |
Artery, Inflammation | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + A + + + + +|
Hematopoietic Cell Proliferation | 3 1 2 2 2 2 2 2 1 2 3 2 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + + + M M M + + M + + + M + + + M + + + + + + +|
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 |
Inflammation, Suppurative | 3 3 |
Mineralization | 1 |
Ulcer | 3 |
Prepuce, Inflammation, Chronic Active| 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 |
Maxilla, Fracture | X |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 |
Meninges, Infiltration Cellular, | |
Mononuclear Cell | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + A + + + + +|
Inflammation, Suppurative | 1 |
Squamous Epithelium, Hyperplasia | 2 1 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X X X X X X X X X X X X X X X X X X X X |
Hemorrhage | 1 |
Inflammation, Chronic Active | 2 1 1 1 2 1 2 2 1 2 1 1 1 1 1 2 2 2 2 1 1 2|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| 6| 6| 5| 7| 7|
DAY ON TEST | 3| 2| 7| 3| 4| 9| 3| 3| 3| 5| 7| 3| 3| 5| 3| 8| 3| 3| 3| 7| 8| 8| 6| 3| 3|
| 3| 8| 8| 3| 4| 7| 4| 4| 4| 7| 8| 3| 4| 0| 5| 2| 3| 5| 3| 2| 1| 1| 2| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.1MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia | 2 |
Artery, Mediastinum, Inflammation | 3 |
Serosa, Cyst | 2 |
Serosa, Fibrosis | 2 2 3 1 2 1 1 2 3 1 2 1 2 1 2 2 2 2 2 3 2 3 1 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 1 |
Olfactory Epithelium, Atrophy | 1 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 |
__________________________________________________________________________|
Pleura | + |
Mesothelium, Hyperplasia | 4 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + A + + + + +|
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Degeneration | 4 |
Cornea, Inflammation | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + A + + + + +|
Infiltration Cellular, Mast Cell | 2 |
Metaplasia, Osseous | |
Nephropathy | 1 1 2 2 1 2 2 1 1 2 1 2 1 1 1 1 1 1 1|
Artery, Inflammation | 1 2 2 |
Capsule, Hemorrhage | 4 |
Renal Tubule, Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + A + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 4| 7| 6| |
DAY ON TEST | 6| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3| 3| 3| 6| 7| 8| 3| 3| 3| 3| 3| 9| 3| 2| |
| 4| 4| 4| 5| 7| 3| 3| 5| 5| 5| 3| 3| 4| 3| 9| 2| 1| 4| 3| 3| 4| 4| 1| 4| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0.1MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + A + + + + A + + M + + + M + + + + + + + A| 41 |
Inflammation, Suppurative | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic | 2| 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + A + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + A + + + + + + + + + + + + + + +| 46 |
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + M + A| 42 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + +| 46 |
Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + A + + + + + + + + + + + + A + +| 43 |
Artery, Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X | 2 |
Clear Cell Focus, Multiple | X | 2 |
Eosinophilic Focus | X X X X X X X X X X X| 14 |
Eosinophilic Focus, Multiple | X X | 5 |
Inflammation, Chronic Active | | 1 2.0|
Inflammation, Focal, Granulomatous | | 1 2.0|
Mixed Cell Focus | X | 1 |
Necrosis | | 2 2.5|
Vacuolization Cytoplasmic | 1| 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + | 5 |
Artery, Inflammation | 3 | 1 3.0|
Fat, Necrosis | 2 | 4 2.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 1 | 2 1.5|
Artery, Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
Infiltration Cellular | 4 | 1 4.0|
Inflammation, Chronic | 2 | 1 2.0|
Ulcer | 1 1 | 3 1.0|
Epithelium, Hyperplasia | 2 2 3 2 1 | 8 1.9|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
Infiltration Cellular | 4 | 1 4.0|
Inflammation, Suppurative | 1| 2 1.0|
Necrosis, Focal | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 4| 7| 6| |
DAY ON TEST | 6| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3| 3| 3| 6| 7| 8| 3| 3| 3| 3| 3| 9| 3| 2| |
| 4| 4| 4| 5| 7| 3| 3| 5| 5| 5| 3| 3| 4| 3| 9| 2| 1| 4| 3| 3| 4| 4| 1| 4| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0.1MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Epithelium, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Inflammation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 1 1 2 1 1 1 1 2 1 1 1 1 1 1 1 | 42 1.2|
Mineralization | 1 | 2 1.0|
Artery, Inflammation | 3 2 3 1 1 2 2| 14 1.9|
Epicardium, Inflammation | 3| 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
Hyperplasia | | 2 2.0|
Hypertrophy | 2 1 1 1 1 2 2 1 1 2 1 1 1 | 23 1.3|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 1 | 3 1.3|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + M + + + I M M M + M + + + M + +| 34 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + M + M + + + + + + + + + +| 45 |
Pars Distalis, Hyperplasia | | 1 1.0|
Pars Intermedia, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + A + + + + + M + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 3 3 2 2 2 2 2 2 3 | 19 2.5|
Inflammation | 3 3 | 3 2.7|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 4| 7| 6| |
DAY ON TEST | 6| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3| 3| 3| 6| 7| 8| 3| 3| 3| 3| 3| 9| 3| 2| |
| 4| 4| 4| 5| 7| 3| 3| 5| 5| 5| 3| 3| 4| 3| 9| 2| 1| 4| 3| 3| 4| 4| 1| 4| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0.1MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Atrophy | 2 | 2 1.5|
Interstitial Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 3 2 | 6 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + + + M + + + + M + + + + + + + M + + + + +| 45 |
Foreign Body | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 40 1.0|
Hyperplasia | 3 2 2 2 3 1 4 2 | 22 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + M + + + M + + M M + + M M M + M I + +| 33 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 4 | 1 4.0|
Hyperplasia | 3 2 2 2 2 2 3| 10 2.2|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + M M + + + M + + + + + + + + + + +| 45 |
Foreign Body | 1 1 1 1 1 1 1 1 1| 14 1.0|
Hyperplasia | 2 2 3 2 2 2 2 2 2| 17 2.1|
Artery, Inflammation | 1 | 2 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
Hematopoietic Cell Proliferation | 2 2 1 2 2 4 3 2 1 2 1 | 23 2.0|
Hyperplasia, Lymphoid | 2 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M A + + + + + + + + + + + + M + +| 41 |
Epithelial Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 2 3.0|
Inflammation, Suppurative | 4 | 3 3.3|
Mineralization | | 1 1.0|
Ulcer | | 1 3.0|
Prepuce, Inflammation, Chronic Active| 4 1 | 3 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1 | 2 1.0|
Maxilla, Fracture | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 4| 7| 6| |
DAY ON TEST | 6| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3| 3| 3| 6| 7| 8| 3| 3| 3| 3| 3| 9| 3| 2| |
| 4| 4| 4| 5| 7| 3| 3| 5| 5| 5| 3| 3| 4| 3| 9| 2| 1| 4| 3| 3| 4| 4| 1| 4| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0.1MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration | | 1 1.0|
Meninges, Infiltration Cellular, | | |
Mononuclear Cell | 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | | 1 1.0|
Squamous Epithelium, Hyperplasia | 1| 4 1.3|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X X X X X X X X X X X X X X X X X X X X X| 42 |
Hemorrhage | 2 | 2 1.5|
Inflammation, Chronic Active | 2 2 1 2 1 2 1 2 2 2 2 2 2 1 1 1 2 2 1 2 2 2 2| 45 1.6|
Alveolar Epithelium, Hyperplasia | 4 2 | 3 2.7|
Artery, Mediastinum, Inflammation | 4 | 2 3.5|
Serosa, Cyst | | 1 2.0|
Serosa, Fibrosis | 3 2 1 2 4 1 3 1 2 2 2 2 2 2 2 2 2 1 2 2 3 2 3 2 3| 49 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 1 1 | 4 1.5|
Olfactory Epithelium, Atrophy | 1 | 2 1.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Pleura | + + + | 4 |
Mesothelium, Hyperplasia | 1 2 1 | 4 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 3 |
Degeneration | 4 | 2 4.0|
Cornea, Inflammation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Harderian Gland | + + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Mast Cell | | 1 2.0|
Metaplasia, Osseous | 2 1 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 4| 7| 6| |
DAY ON TEST | 6| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3| 3| 3| 6| 7| 8| 3| 3| 3| 3| 3| 9| 3| 2| |
| 4| 4| 4| 5| 7| 3| 3| 5| 5| 5| 3| 3| 4| 3| 9| 2| 1| 4| 3| 3| 4| 4| 1| 4| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0.1MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3 | 41 1.2|
Artery, Inflammation | 3 1 3 | 6 2.0|
Capsule, Hemorrhage | 4 | 2 4.0|
Renal Tubule, Hyperplasia | 1 1 | 3 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 5| 7| 7| 7| 6| 7| 5| 7| 5| 6| 7| 7| 5| 7| 6| 5| 7| 5| 7| 7|
DAY ON TEST | 3| 1| 7| 6| 3| 6| 3| 3| 3| 3| 3| 9| 1| 8| 8| 2| 0| 8| 3| 0| 6| 3| 0| 3| 3|
| 4| 9| 1| 8| 3| 2| 4| 4| 3| 2| 3| 5| 5| 9| 7| 7| 6| 9| 3| 8| 2| 3| 1| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.3MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + A + + + + + A + + + + A + + + + + + + A + +|
Degeneration, Hyaline | 2 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + A + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + A + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + A + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + A + + + + + + + + + + + + + + +|
Fibrosis | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + A + +|
Epithelium, Hyperplasia | 2 |
Peyer's Patch, Hyperplasia | 1 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Eosinophilic Focus | X X X X X X X |
Eosinophilic Focus, Multiple | X |
Mixed Cell Focus | X |
Necrosis | 2 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + + + +|
Artery, Inflammation | 3 |
Fat, Inflammation | |
Fat, Necrosis | 2|
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + A + + + + + + + + + + + + + + +|
Atrophy | 1 |
Hypertrophy | 1 |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 2 |
Ulcer | 1 |
Epithelium, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 |
Necrosis, Focal | 2 |
__________________________________________________________________________|
Tooth | |
Malformation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Mineralization | |
Artery, Inflammation | 2 3 2 2 1 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 5| 7| 7| 7| 6| 7| 5| 7| 5| 6| 7| 7| 5| 7| 6| 5| 7| 5| 7| 7|
DAY ON TEST | 3| 1| 7| 6| 3| 6| 3| 3| 3| 3| 3| 9| 1| 8| 8| 2| 0| 8| 3| 0| 6| 3| 0| 3| 3|
| 4| 9| 1| 8| 3| 2| 4| 4| 3| 2| 3| 5| 5| 9| 7| 7| 6| 9| 3| 8| 2| 3| 1| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.3MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Atrium, Inflammation, Chronic | 4 |
Atrium, Metaplasia, Osseous | 3 |
Atrium, Thrombosis | 4 |
Pericardium, Inflammation | 2 2 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Hypertrophy | 1 1 1 1 1 1 3 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + M + + + + + + + + + + + +|
Hyperplasia | 1 1 1 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 |
__________________________________________________________________________|
Parathyroid Gland | + I + + M + + + M + + M + + M M + M + + M M M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Intermedia, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 4 |
Inflammation | 1 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 4 2 2 3 3 2 3 2 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + A + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + A + + + + + + + + + + + + A + +|
Congestion | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Inflammation, Granulomatous | |
Interstitial Cell, Hyperplasia | 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Hyperplasia | 2 1 1 2 2 2 2 2 2 |
Artery, Inflammation | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 5| 7| 7| 7| 6| 7| 5| 7| 5| 6| 7| 7| 5| 7| 6| 5| 7| 5| 7| 7|
DAY ON TEST | 3| 1| 7| 6| 3| 6| 3| 3| 3| 3| 3| 9| 1| 8| 8| 2| 0| 8| 3| 0| 6| 3| 0| 3| 3|
| 4| 9| 1| 8| 3| 2| 4| 4| 3| 2| 3| 5| 5| 9| 7| 7| 6| 9| 3| 8| 2| 3| 1| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.3MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M M + + + + M + M M + + M + + + M + + + M +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + + A + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + + + + + + + + + + M + + + + + + + + + + + +|
Foreign Body | 1 1 1 1 1 1 1 1 1|
Hematopoietic Cell Proliferation | 2 |
Hyperplasia | 2 2 2 2 2 2 2 2 2 4|
Infiltration Cellular, Histiocyte | 4 |
Artery, Inflammation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + A + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 1|
Hyperplasia, Lymphoid | 2 2|
__________________________________________________________________________|
Thymus | + + M + + + + + + M + + M M + M + + + M + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Prepuce, Inflammation, Chronic Active| 3 |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 |
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
Squamous Epithelium, Hyperplasia | 1 2 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X X X X X X X X X X X X X X X X X X X X X X X X|
Hemorrhage | 1 1 |
Infiltration Cellular, Mast Cell | |
Inflammation, Chronic Active | 2 2 1 3 3 3 2 2 2 2 3 2 4 2 2 2 1 2 2 2 1 3 2|
Alveolar Epithelium, Hyperplasia | 2 1 1 1 |
Alveolus, Proteinosis | 1 1 1 |
Serosa, Fibrosis | 2 2 1 2 2 2 2 2 2 1 4 2 2 4 3 3 4 3 1 1 3 2 2 4 2|
Serosa, Metaplasia, Osseous | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 5| 7| 7| 7| 6| 7| 5| 7| 5| 6| 7| 7| 5| 7| 6| 5| 7| 5| 7| 7|
DAY ON TEST | 3| 1| 7| 6| 3| 6| 3| 3| 3| 3| 3| 9| 1| 8| 8| 2| 0| 8| 3| 0| 6| 3| 0| 3| 3|
| 4| 9| 1| 8| 3| 2| 4| 4| 3| 2| 3| 5| 5| 9| 7| 7| 6| 9| 3| 8| 2| 3| 1| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.3MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Olfactory Epithelium, Atrophy | |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 1 1 |
__________________________________________________________________________|
Pleura | + + + + |
Mesothelium, Hyperplasia | 1 1 4 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + A + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Inflammation | |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
Inflammation, Chronic Active | 1 2|
Metaplasia, Osseous | |
Nephropathy | 2 1 1 1 1 1 1 1 3 1 1 3 1 1 1 1 3 2 1 1|
Artery, Inflammation | 1 |
Capsule, Inflammation, Chronic | |
Renal Tubule, Hyperplasia | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + A + + + + + + + + + + + + + + +|
Degeneration | 2 |
Inflammation | 3 |
Transitional Epithelium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
__________________________________________________________________________________________________________________________________
| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 4| 7| 7| |
DAY ON TEST | 3| 4| 7| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 4| 3| 3| 3| 6| 1| 3| 3| 3| 7| 3| 3| |
| 4| 5| 0| 4| 3| 4| 3| 5| 4| 3| 5| 5| 4| 8| 3| 4| 3| 4| 5| 3| 3| 3| 1| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
0.3MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + A A M + + + + M + + + + A + + + + A + + + A I +| 38 |
Degeneration, Hyaline | 2 | 2 2.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + A + +| 46 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + + + A + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + + + A + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + + + + + + + A + + + + + + + + A + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + A + + + + + A + + + + + + + + A + +| 44 |
Fibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + + + + + A + + + + + + + + A + +| 45 |
Epithelium, Hyperplasia | | 1 2.0|
Peyer's Patch, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Eosinophilic Focus | X X X | 10 |
Eosinophilic Focus, Multiple | X X X X X X X| 8 |
Mixed Cell Focus | | 1 |
Necrosis | 1 3 | 7 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 8 |
Artery, Inflammation | | 1 3.0|
Fat, Inflammation | 2 | 1 2.0|
Fat, Necrosis | 2 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Oral Mucosa | A | |
__________________________________________________________________________|____________|
Pancreas | + + A + + + + + + + + + + + + + + + + + + + A + +| 47 |
Atrophy | 1 | 2 1.0|
Hypertrophy | 2 | 2 1.5|
Duct, Cyst | 4 | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 2 2.0|
Ulcer | | 1 1.0|
Epithelium, Hyperplasia | 4 2 | 5 2.4|
__________________________________________________________________________|____________|
Stomach, Glandular | + + A + + + + + + + + + + + + + + + + + + + A + +| 47 |
Inflammation, Suppurative | | 2 2.0|
Necrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + + | 2 |
Malformation | X X | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
__________________________________________________________________________________________________________________________________
| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 4| 7| 7| |
DAY ON TEST | 3| 4| 7| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 4| 3| 3| 3| 6| 1| 3| 3| 3| 7| 3| 3| |
| 4| 5| 0| 4| 3| 4| 3| 5| 4| 3| 5| 5| 4| 8| 3| 4| 3| 4| 5| 3| 3| 3| 1| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
0.3MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1| 41 1.0|
Mineralization | 1 | 1 1.0|
Artery, Inflammation | 3 2 2 1 | 10 2.0|
Atrium, Inflammation, Chronic | | 1 4.0|
Atrium, Metaplasia, Osseous | | 1 3.0|
Atrium, Thrombosis | 2 | 2 3.0|
Pericardium, Inflammation | 2 2 | 5 2.2|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
Hypertrophy | 1 1 1 1 1 1 1 1 2 1 1 | 19 1.2|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 | 6 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + A + + + + + + + + + + + + + + + + + + + A + +| 47 |
Hyperplasia | 2 1 | 4 1.8|
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + M + + + + M + M M + + + + M + + + + + +| 34 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Intermedia, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | 2 | 2 3.0|
Inflammation | 1 | 2 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
Ectasia | 4 2 2 2 3 2 2 2 2 2 | 20 2.4|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + I + + + + + + + + + + + +| 48 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + A + + + + + + + + + + + + + + + + + + + + + +| 47 |
Congestion | 4 | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 | 2 1.0|
Inflammation, Granulomatous | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
__________________________________________________________________________________________________________________________________
| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 4| 7| 7| |
DAY ON TEST | 3| 4| 7| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 4| 3| 3| 3| 6| 1| 3| 3| 3| 7| 3| 3| |
| 4| 5| 0| 4| 3| 4| 3| 5| 4| 3| 5| 5| 4| 8| 3| 4| 3| 4| 5| 3| 3| 3| 1| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
0.3MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Interstitial Cell, Hyperplasia | 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + M + + + + + +| 48 |
Foreign Body | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 40 1.0|
Hyperplasia | 2 2 3 2 2 2 2 2 2 2 3 2 2| 22 2.0|
Artery, Inflammation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + M M + + + + + M + + M + M + + M + + +| 36 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + M + + + + + + + + A + +| 45 |
Hyperplasia | 4 2 2 2 2 2 2| 10 2.2|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Foreign Body | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 25 1.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia | 2 2 2 2 2 2 2 3 4 3 2 2 2 2 2 2 2 | 27 2.2|
Infiltration Cellular, Histiocyte | | 1 4.0|
Artery, Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + A + +| 48 |
Hematopoietic Cell Proliferation | 2 2 2 1 2 2 2 1 2 1 1 2 | 29 1.9|
Hyperplasia, Lymphoid | 2 | 3 2.0|
__________________________________________________________________________|____________|
Thymus | + + M M + + M + + M + M M + M M + + + M + + + + +| 35 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Prepuce, Inflammation, Chronic Active| 2 4 | 3 3.0|
Subcutaneous Tissue, Edema | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 | 2 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Developmental Malformation | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
__________________________________________________________________________________________________________________________________
| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 4| 7| 7| |
DAY ON TEST | 3| 4| 7| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 4| 3| 3| 3| 6| 1| 3| 3| 3| 7| 3| 3| |
| 4| 5| 0| 4| 3| 4| 3| 5| 4| 3| 5| 5| 4| 8| 3| 4| 3| 4| 5| 3| 3| 3| 1| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
0.3MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 1 1 | 4 1.0|
Squamous Epithelium, Hyperplasia | 2 2 2 1 | 7 1.7|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X X X X X X X X X X X X X X X X X X X X X X X X| 49 |
Hemorrhage | | 2 1.0|
Infiltration Cellular, Mast Cell | 4 | 1 4.0|
Inflammation, Chronic Active | 2 2 2 2 2 2 1 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 46 2.1|
Alveolar Epithelium, Hyperplasia | 4 2 4 | 7 2.1|
Alveolus, Proteinosis | 1 1 1 1 1 1 1 | 10 1.0|
Serosa, Fibrosis | 3 4 3 3 2 2 1 4 3 3 1 1 3 4 2 3 3 2 3 4 2 2 1 3 2| 50 2.4|
Serosa, Metaplasia, Osseous | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 1 1 1 | 5 1.0|
Olfactory Epithelium, Atrophy | 1 | 1 1.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | | 4 1.0|
__________________________________________________________________________|____________|
Pleura | + + | 6 |
Mesothelium, Hyperplasia | 1 1 | 6 1.5|
__________________________________________________________________________|____________|
Trachea | + + A + + + + + + + + + + + + + + + + + + + A + +| 47 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Cornea, Inflammation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | 4 | 2 3.0|
Inflammation, Chronic Active | | 2 1.5|
Metaplasia, Osseous | 1 | 1 1.0|
Nephropathy | 1 1 1 1 1 1 1 2 1 1 1 1 2 1 1 1 1 1 1 1 1| 41 1.2|
Artery, Inflammation | 2 | 2 1.5|
Capsule, Inflammation, Chronic | 2 | 1 2.0|
Renal Tubule, Hyperplasia | 1 1 1| 5 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + A + + + + + + + + + + + + + + + + + + + A + +| 47 |
Degeneration | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21
__________________________________________________________________________________________________________________________________
| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 4| 7| 7| |
DAY ON TEST | 3| 4| 7| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 4| 3| 3| 3| 6| 1| 3| 3| 3| 7| 3| 3| |
| 4| 5| 0| 4| 3| 4| 3| 5| 4| 3| 5| 5| 4| 8| 3| 4| 3| 4| 5| 3| 3| 3| 1| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
0.3MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Inflammation | | 1 3.0|
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------
--multipart-boundary
Content-type: text/plain
Range: bytes 649416-649416/649416
--multipart-boundary--